342,418 results match your criteria Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology[Journal]


Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

4Department of Neurosurgery, The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, People's Republic of China.

OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity in glioma cells.METHODSThe authors used glioma tissue samples from glioma patients, cells from glioblastoma (GBM) cell lines and normal human astrocyte cells, and subcutaneous tumor-bearing U87 cells in mice to examine the effects of signaling regulation by miR-448 in the response of glioma tissues and cells to radiation treatment. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.12.JNS181798DOI Listing
April 2019
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Neurological and neuropsychological outcome after resection of craniopharyngiomas.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

OBJECTIVECraniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality of life have been neglected for many decades. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.10.JNS181557DOI Listing
April 2019
1 Read

The challenge to predict mobilized peripheral blood stem cells on the fourth day of G-CSF treatment in healthy donors: the predictive value of basal CD34+ cell and platelet counts.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Institute of Clinical Physiology (IFC-CNR), Rome, Italy.

A longitudinal, prospective, observational, single-center, cohort study on healthy donors (HDs) was designed to identify predictors of CD34+ cell mobilization on day 4 after G-CSF administration. As potential predictors of mobilization, age, sex, body weight, height, blood volume, as well as white blood cell count (WBC), peripheral blood (PB) mononuclear cells (PBMC) count, platelet (Plt) count, hematocrit, and hemoglobin levels were considered. Two different evaluations of CD34+ cell counts were determined for each donor: baseline (before granulocyte colony-stimulating factor [G-CSF] administration) and in PB on day 4 after G-CSF administration. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.011DOI Listing

[18F]fludeoxyglucose PET/CT in small-cell lung cancer: Analysis of the CONVERT randomized controlled trial.

J Thorac Oncol 2019 Apr 16. Epub 2019 Apr 16.

Division of Cancer Sciences, University of Manchester, Manchester, UK; Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK.

Introduction: We used phase-3 CONVERT trial data to investigate the impact of fludeoxyglucose (F-FDG) PET/CT in small-cell lung cancer (SCLC).

Methods: CONVERT randomized limited-stage SCLC patients to twice-daily (45Gy in 30-fractions) or once-daily (66Gy in 33-fractions) chemoradiotherapy. Patients were divided into 2 groups in this unplanned analysis: those staged with conventional imaging (contrast-enhanced thorax and abdomen CT and brain imaging with/without bone scintigraphy) and those staged with F-FDG PET/CT in addition. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.03.023DOI Listing

Real-world treatment of stage III NSCLC: the role of trimodality treatment in the era of immunotherapy.

J Thorac Oncol 2019 Apr 16. Epub 2019 Apr 16.

University of British Columbia, 2329 West Mall, Vancouver, BC, Canada V6T 1Z4; Department of Medical Oncology, BC Cancer, 600 W 10th Avenue, Vancouver, BC, Canada V5Z 4E6. Electronic address:

Introduction: Curative intent treatment of stage III NSCLC is variable and influenced by both patient and disease characteristics. We performed a real-world analysis of curative therapies in stage III NSCLC, and explored the impact of known prognostic factors on outcome.

Methods: A retrospective review was completed of all patients with stage III NSCLC between January 2005 and December 2012. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.04.005DOI Listing

Radiotherapy Workflow and Dosimetric Analysis from a Phase I/II Trial of Noninvasive Cardiac Radioablation for Ventricular Tachycardia.

Int J Radiat Oncol Biol Phys 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO.

Introduction: A prospective phase I/II trial for electrophysiologic-guided noninvasive cardiac radioablation treatment of ventricular tachycardia (VT) (XXXX) demonstrating efficacy for arrhythmia control has recently been reported. The treatment workflow, report dose-volume metrics, and overall process improvements are described here.

Methods: Patients receiving 25 Gy in a single fraction to the cardiac VT substrate (identified on pre-simulation multimodality imaging) on the phase I/II trial were included for analysis. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.005DOI Listing

Stereotactic Body Radiotherapy Boost for Intermediate Risk Prostate Cancer: A Phase 1 Dose Escalation Study.

Int J Radiat Oncol Biol Phys 2019 Apr 16. Epub 2019 Apr 16.

Sunnybrook Odette Centre; Department of Radiation Oncology, University of Toronto. Electronic address:

Purpose: HDR brachytherapy boost plus external beam radiotherapy is an established option for intermediate risk prostate cancer (PCa). SBRT boost can potentially mimic HDR boost, and could be a viable alternative. Here we report the long-term outcomes of a phase I dose-escalation trial of single-fraction SBRT boost. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.006DOI Listing

Outcomes of Zygomatic Complex Reconstruction With Patient-Specific Titanium Mesh Using Computer-Assisted Techniques.

J Oral Maxillofac Surg 2019 Mar 23. Epub 2019 Mar 23.

Professor, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China. Electronic address:

Purpose: Zygomatic complex defects after extensive maxillectomy can cause severe esthetic and functional deformities. Patient-specific titanium mesh fabricated using a computer-assisted technique is a promising method for such midface reconstruction. The aim of this study was to evaluate the application and clinical outcomes of this technique. Read More

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http://dx.doi.org/10.1016/j.joms.2019.03.014DOI Listing

Long-term biochemical progression-free survival following brachytherapy for prostate cancer: Further insight into the role of short-term androgen deprivation and intermediate risk group subclassification.

PLoS One 2019 19;14(4):e0215582. Epub 2019 Apr 19.

Department of Urology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction: Brachytherapy is a well-established treatment of localized prostate cancer. Few studies have documented long-term results, specifically biochemical progression-free survival (bPFS) in men with brachytherapy alone, with or without short-term androgen deprivation therapy (ADT), or in combination with external beam radiotherapy (EBRT). Our aim was to analyze long-term bPFS of brachytherapy treated patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215582PLOS

FDG PET based prediction of response in head and neck cancer treatment: Assessment of new quantitative imaging features.

PLoS One 2019 19;14(4):e0215465. Epub 2019 Apr 19.

Department of Radiation Oncology, The University of Iowa, Iowa City, United States of America.

Introduction: 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is now a standard diagnostic imaging test performed in patients with head and neck cancer for staging, re-staging, radiotherapy planning, and outcome assessment. Currently, quantitative analysis of FDG PET scans is limited to simple metrics like maximum standardized uptake value, metabolic tumor volume, or total lesion glycolysis, which have limited predictive value. The goal of this work was to assess the predictive potential of new (i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215465PLOS

Evaluation of Three Rapid Screening Tests for Detection of Hepatitis C Antibodies on Mass Scale.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):25-28

Department of Biotechnology, International Islamic University, Islamabad, Pakistan.

Hepatitis C virus (HCV) is a leading health problem across the globe. Only 20% of HCV positive individuals know their positive disease status. Effective HCV screening tests are required to screen both general and high-risk populations and identify the silent cases of HCV. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025062DOI Listing
January 2019
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The Role of Melanin in Skin Cancer.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):17-24

Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.

Low melanin level in white skin results in many genetic alterations that activate oncogenes to form metastatic melanomas because of interaction with ultraviolet rays. These melanomas are uncommon, but they are dangerous and spread rapidly in the individual's body. Individuals with fair, freckled skin; a weak immune system; or have a personal or family history of melanoma are at high risk to have melanoma. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018024980DOI Listing
January 2019

Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro.

Oncol Rep 2019 Apr 8. Epub 2019 Apr 8.

Department of Molecular and Cellular Biology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, 50‑556 Wroclaw, Poland.

Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide spectrum of biological and pharmacological effects, its effect may be limited its lipophobic properties. Therefore, strategies to improve the access of BTA to the cells are required to enhance the anticancer effects. Read More

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http://dx.doi.org/10.3892/or.2019.7103DOI Listing

Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma.

Oncol Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Medical Joint Materials, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan.

The treatment of glioblastoma is a critical health issue, owing to its resistance to chemotherapy. The current standard of treatment is surgical resection, followed by adjuvant radiotherapy and temozolomide treatment. Long‑term local treatment of glioblastoma is rarely achieved and the majority of the patients undergo relapse. Read More

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http://dx.doi.org/10.3892/or.2019.7100DOI Listing

Upregulation of LGMNP1 confers radiotherapy resistance in glioblastoma.

Oncol Rep 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurosurgery, Shanghai Pudong Hospital, Fudan University, Pudong, Shanghai 200120, P.R. China.

Glioblastoma is a lethal brain tumor type, which is frequently resistant to radiotherapy. The aim of the present study was to explore the function of legumain pseudogene 1 (LGMNP1) on radioresistance in glioblastoma. Reverse transcription‑quantitative PCR was used to detect the relative expression of LGMNP1 in glioma cell lines after radiotherapy. Read More

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http://dx.doi.org/10.3892/or.2019.7128DOI Listing

Similarities in mRNA expression of peripheral blood drug metabolizing enzymes and cancer marker genes with biopsy samples of head and neck cancer patients.

Biomarkers 2019 Apr 19:1-30. Epub 2019 Apr 19.

a Developmental Toxicology Laboratory, System Toxicology & Health Risk Assessment Group , CSIR-Indian Institute of Toxicology Research (CSIR-IITR) , Vishvigyan Bhawan, 31, Mahatma Gandhi Marg , Lucknow - 226001 , U.P , India.

Purpose: To develop peripheral blood mRNA expression profiles of drug metabolizing enzymes (DMEs) as a surrogate to monitor tobacco induced head & neck squamous cell carcinoma (HNSCC), attempts were made to investigate i) similarities in alterations with the cancer marker genes in biopsy samples, and ii) if alterations similar to that seen in biopsy samples are reflected in peripheral blood.

Methods: Total RNA from eight soft gingival tissues and eight biopsy samples of HNSCC patients and total DNA and RNA from blood of healthy controls (n = 150) and HNSCC patients (n = 150) was processed for expression and genotyping studies. Blood from patients receiving chemo-radiotherapy was processed for follow-up study Results: qRT-PCR revealed significant increase in mRNA expression of DMEs in biopsy and blood samples of HNSCC patients when compared to controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/1354750X.2019.1
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http://dx.doi.org/10.1080/1354750X.2019.1609090DOI Listing
April 2019
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Shape Constrained Fully Convolutional DenseNet with Adversarial Training for Multi-organ Segmentation on Head and Neck CT and Low Field MR Images.

Med Phys 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

Purpose: Image guided radiotherapy provides images not only for patient positioning but also for online adaptive radiotherapy. Accurate delineation of organs-at-risk (OARs) on Head and Neck (H&N) CT and MR images is valuable to both initial treatment planning and adaptive planning, but manual contouring is laborious and inconsistent. A novel method based on the generative adversarial network (GAN) with shape constraint (SC-GAN) is developed for fully automated H&N OARs segmentation on CT and low field MRI. Read More

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http://dx.doi.org/10.1002/mp.13553DOI Listing

HCP5 promotes colon cancer development by activating AP1G1 via PI3K/AKT pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2786-2793

Department of Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, China.

Objective: To explore whether HCP5 participates in the pathogenic progression of colon cancer (CC) and its underlying mechanism.

Patients And Methods: HCP5 expression in CC tissues and cell lines was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlation between the HCP5 expression and tumor stage of CC patients was then analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17553DOI Listing

Astragaloside attenuates lipopolysaccharide-induced cell apoptosis in human gingiva cells via MAPK signaling pathway.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, China.

Subjects: The aim of this study was to research the antiapoptotic effect of astragaloside, the principal component of Astragalus membranaceus (Fisch) Bge, in human gingiva cells induced by lipopolysaccharide (LPS).

Methods: According to the treatment, human gingiva cells were divided into five groups, including (1) control group without drug treatment; (2) imitating group, treated with LPS (10 μg·mL ) alone; (3) low group, treated with LPS and 50 μmol·L astragaloside; (4) medium group, treated with LPS and 100 μmol·L astragaloside; and (5) high group, treated with LPS and 150 μmol·L astragaloside. Cell proliferation and apoptosis were investigated using MTT assay and flow cytometry, respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28286
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http://dx.doi.org/10.1002/jcb.28286DOI Listing
April 2019
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Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin.

Ann Hematol 2019 Apr 19. Epub 2019 Apr 19.

Department of Hematology and Oncology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Extranodal NK/T cell lymphoma (NKTCL), nasal type (ENKL) that shows no apparent nasal involvement, is termed extranasal NKTCL or non-nasal NKTCL. In this study, we aimed to explore therapeutic approaches and outcomes in patients with extranasal NKTCL in current clinical practice. A data set of patients with newly diagnosed NKTCL who were diagnosed at 31 institutes in Japan between 2000 and 2013 was used for analysis. Read More

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http://dx.doi.org/10.1007/s00277-019-03689-9DOI Listing
April 2019
2 Reads

Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?

Neuroradiology 2019 Apr 18. Epub 2019 Apr 18.

Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Purpose: To assess the prevalence of false-positive meningeal contrast enhancement in patients with solid tumors who were undergoing chemotherapy.

Methods: A total of 2572 magnetic resonance imaging (MRI) examinations of the brain were retrospectively evaluated by two readers for the presence of pathological meningeal contrast enhancement conspicuous for neoplastic meningitis. These patients either had malignant melanoma, breast or lung cancer, or lymphoma. Read More

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http://link.springer.com/10.1007/s00234-019-02215-y
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http://dx.doi.org/10.1007/s00234-019-02215-yDOI Listing
April 2019
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[Whole- or partial-breast radiotherapy after 5 years from a patient perspective: longitudinal analysis of the IMPORT LOW (CRUK/06/003) phase III trial].

Strahlenther Onkol 2019 Apr 18. Epub 2019 Apr 18.

Klinik für Strahlentherapie, Campus Kiel, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01472-3DOI Listing

Dosimetric Comparison of Three-Dimensional Conformal Radiotherapy (3D-CRT) and Intensity Modulated Radiotherapy Techniques (IMRT) with Radiotherapy Dose Simulations for Left-Sided Mastectomy Patients.

Eur J Breast Health 2019 Apr 1;15(2):85-89. Epub 2019 Apr 1.

Department of Radiation Oncology, Necmettin Erbakan University School of Medicine, Konya, Turkey.

Objective: To compare 3-dimensional conformal radiotherapy (3D-CRT) and intensity modulated radiotherapy (IMRT) techniques on the target tissue and critical organ doses in terms of dosimetry, during treatment planning of patient's post-mastectomy radiotherapy (PMRT) to the left chest wall.

Materials And Methods: Twenty breast cancer patients with left-sided post-mastectomy have selected for PMRT both 3D-CRT and IMRT techniques. Dosimetric calculation of dose simulation in Eclipse treatment planning system have been performed. Read More

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http://dx.doi.org/10.5152/ejbh.2019.4619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456270PMC

Phase 2 Multicenter Study of Gantry-Based Stereotactic Radiotherapy Boost for Intermediate and High Risk Prostate Cancer (PROMETHEUS).

Front Oncol 2019 2;9:217. Epub 2019 Apr 2.

Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia.

To report feasibility, early toxicity, and PSA kinetics following gantry-based, stereotactic radiotherapy (SBRT) boost within a prospective, phase 2, multicenter study (PROMETHEUS: ACTRN12615000223538). Patients were treated with gantry-based SBRT, 19-20 Gy in two fractions delivered 1 week apart, followed by conventionally fractionated IMRT (46 Gy in 23 fractions). The study mandated MRI fusion for RT planning, rectal displacement, and intrafraction image guidance. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00217/
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http://dx.doi.org/10.3389/fonc.2019.00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454110PMC
April 2019
1 Read

Radiotherapy Both Promotes and Inhibits Myeloid-Derived Suppressor Cell Function: Novel Strategies for Preventing the Tumor-Protective Effects of Radiotherapy.

Front Oncol 2019 2;9:215. Epub 2019 Apr 2.

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, United States.

Cancer immunotherapies aimed at neutralizing the programmed death-1 (PD-1) immune suppressive pathway have yielded significant therapeutic efficacy in a subset of cancer patients. However, only a subset of patients responds to antibody therapy with either anti-PD-1 or anti-PD-L1 antibodies. These patients appear to have so-called "hot" tumors containing tumor-reactive T cells. Read More

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http://dx.doi.org/10.3389/fonc.2019.00215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454107PMC

A Review on the Special Radiotherapy Techniques of Colorectal Cancer.

Front Oncol 2019 2;9:208. Epub 2019 Apr 2.

Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Colorectal cancer is one of the commonest cancers worldwide. Radiotherapy has been established as an indispensable component of treatment. Although conventional radiotherapy provides good local control, radiotherapy treatment side-effects, local recurrence and distant metastasis remain to be the concerns. Read More

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http://dx.doi.org/10.3389/fonc.2019.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454863PMC

Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study.

J Clin Exp Dent 2019 Mar 1;11(3):e236-e243. Epub 2019 Mar 1.

Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, Brasil.

Background: Radiation-related caries (RRC) is one of the most significant oral toxicities of head and neck radiotherapy (HNRT); however, the potential of radiation to directly cause harmful dentin and pulpal effects and impair response to caries progression is controversial.

Material And Methods: Therefore, the aim of this study was to characterize the reactions of the dentin-pulp complex in teeth affected by RRC. Patients and methods: Twenty-two carious teeth extracted from 22 head and neck cancer (HNC) patients were divided into control (conventional caries; n=11) and irradiated (RRC; n=11) groups and paired matched by dental homology, clinical patterns of caries progression following the Post-Radiation Dental Index (PRDI) and microscopic depth of carious invasion. Read More

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http://dx.doi.org/10.4317/jced.55370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461726PMC

ROS Reduction Does Not Decrease the Anticancer Efficacy of X-Ray in Two Breast Cancer Cell Lines.

Oxid Med Cell Longev 2019 14;2019:3782074. Epub 2019 Mar 14.

High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.

Radiotherapy is effective on a large number of cancer types and is one of the most frequently administrated treatments for cancer patients. The anticancer efficacy of X-ray radiotherapy has been frequently correlated with reactive oxygen species (ROS) elevation, which is also a limiting factor for its toxicity on normal tissues. Here, we found that although 4-10 Gy X-rays could significantly reduce cell numbers in both MDA-MB-231 and MCF-7 breast cancer cells, the ROS level changes are less in MCF-7 cells than in MDA-MB-231 cells. Read More

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https://www.hindawi.com/journals/omcl/2019/3782074/
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http://dx.doi.org/10.1155/2019/3782074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437742PMC
March 2019
1 Read

Intracranial Hemorrhage in a Young Woman: An Unusual Initial Presentation of Undiagnosed Choriocarcinoma.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):371-373

Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.

Choriocarcinoma is an uncommon tumor. Undiagnosed choriocarcinoma initially presenting with intracranial hemorrhage in an apparently healthy female is rare and presents a diagnostic difficulty. The authors report a case presenting as intracranial hemorrhage of unsuspected choriocarcinoma. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_307_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454938PMC

Down-regulation of human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation.

Clin Cancer Res 2019 Apr 18. Epub 2019 Apr 18.

Urology, UT Southwestern Medical Center

Purpose: Renal cell carcinoma (RCC) is known to be highly radio-resistant but the mechanisms associated with radio-resistance have remained elusive. We found DAB2IP frequently down-regulated in RCC, is associated with radio-resistance. In this study, we investigated the underlying mechanism regulating radio-resistance by DAB2IP and developed appropriate treatment. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3004DOI Listing

FOLFIRINOX-based neoadjuvant chemoradiotherapy for borderline and locally advanced pancreatic cancer: A pilot study from a tertiary centre.

Dig Liver Dis 2019 Apr 15. Epub 2019 Apr 15.

CHU Bordeaux, Department of Radiotherapy, Bordeaux, France; Bordeaux University, INSERM U1035, Bordeaux, France. Electronic address:

Background: Neoadjuvant chemoradiotherapy, potentially relevant to increase resection rate in pancreatic cancer, is still debated.

Aims: To assess tolerance, resection rate and outcomes of patients with non-metastatic pancreatic ductal adenocarcinoma treated by concomitant chemoradiotherapy.

Methods: This monocentric study included all consecutive patients treated from 2010 to 2014 for non-metastatic pancreatic adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.dld.2019.03.004DOI Listing

Long-term results of fertility-sparing treatment for early-stage cervical cancer.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy.

Objective: To evaluate the long-term outcomes of young early stage cervical cancer patients wishing to preserve their childbearing potential.

Methods: Data of young (aged <40 years) patients with early stage cervical cancer were prospectively collected. All patients with stage IA2, IB1 and IB2 cervical cancer were included; they have cervical conization and pelvic node dissection performed via minimally invasive surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193050
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http://dx.doi.org/10.1016/j.ygyno.2019.04.007DOI Listing
April 2019
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Nasopharyngeal carcinoma with cutaneous metastases.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of radiotherapy, Farhat Hached hospital, Sousse, Tunisia.

Introduction: Cutaneous metastases from nasopharyngeal carcinoma are extremely rare and associated with a poor prognosis.

Case Reports: We retrospectively reviewed 820 patients with nasopharyngeal carcinoma treated over a 20-year period in the radiotherapy department of Farhat Hached hospital in Sousse and Ibn Khaldoun Medical centre, Hammam Sousse. Two of these patients presented cutaneous metastases. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.005DOI Listing
April 2019
2 Reads

Perineural Invasion in Cutaneous Squamous Cell Carcinoma.

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. Read More

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http://dx.doi.org/10.1016/j.ad.2018.10.006DOI Listing

Radio-sensitization efficacy of gold nanoparticles in inhalational nanomedicine and the adverse effect of nano-detachment due to coating inactivation.

Phys Med 2019 Apr 21;60:7-13. Epub 2019 Mar 21.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Gold nanoparticles (GNPs) are an emerging area of interest in radiation therapy due to their unique radio-sensitizing properties. In the literature, the enhancing capability of GNPs is usually quantified using the metric dose enhancement ratio (DER). Traditionally, the focus of the vast majority of studies has always been on intravenous administration of GNPs. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.02.013DOI Listing

Geant4 physics list comparison for the simulation of phase-contrast mammography (XPulse project).

Phys Med 2019 Apr 28;60:66-75. Epub 2019 Mar 28.

Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076 Bordeaux, France.

Purpose: Breast cancer is the most frequent cancer in women. Early and accurate detection of the disease is a major factor in patient survival. To this end, phase-contrast imaging has gained significant interest in recent years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797193007
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http://dx.doi.org/10.1016/j.ejmp.2019.03.026DOI Listing
April 2019
1 Read

Risk of contralateral breast and ipsilateral lung cancer induction from forward-planned IMRT for breast carcinoma.

Phys Med 2019 Apr 25;60:44-49. Epub 2019 Mar 25.

Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, 71003 Iraklion, Crete, Greece.

Purpose: To assess the risk of contralateral breast and ipsilateral lung cancer induction from forward-planned IMRT for breast carcinoma.

Methods: The study group included 13 females irradiated for breast cancer with 6 MV photons. The plans were initially generated by using standard fractionated (SF) forward-planned IMRT (50 Gy at 2 Gy/fraction). Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.021DOI Listing

Breast intraoperative electron radiotherapy: Image-based setup verification and in-vivo dosimetry.

Phys Med 2019 Apr 24;60:37-43. Epub 2019 Mar 24.

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Shohadaye Tajrrish Hospital, Tajrish Sq., P.O. 19996 14414, Tehran, Iran.

Introduction: Single fraction nature of intraoperative radiotherapy highly demands a quality assurance procedure to qualify both beam setup and treatment delivery. The aim of this study is to evaluate the treatment setup during breast intraoperative electron radiotherapy (IOERT) and in-vivo dose delivery verification.

Materials And Methods: Twenty-five breast cancer patients were enrolled and setup verification for each case was performed using C-arm imaging. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.017DOI Listing

Enhancement of linear energy transfer in gold nanoparticles mediated radiation therapy.

Phys Med 2019 Apr 22;60:22-29. Epub 2019 Mar 22.

Department of Radiation Oncology, University of Washington School of Medicine, WA 98195, USA.

Objective: The metric dose enhancement ratio (DER) has been widely used to assess the enhancing capability of gold nanoparticles (GNPs). However, there is a large disparity between the observed radiobiological outcome and DER values. A new metric, linear energy transfer enhancement ratio (LETER), is introduced to bridge the gap between theoretical predictions and the experimentally measured sensitization. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.02.019DOI Listing

Accuracy and stability of deep inspiration breath hold in gated breast radiotherapy - A comparison of two tracking and guidance systems.

Phys Med 2019 Apr 9;60:174-181. Epub 2019 Apr 9.

Department of Radiation Oncology, University of Washington, Seattle, WA, United States; Department of Radiation Oncology, Seattle Cancer Care Alliance, Seattle, WA, United States.

Purpose: To characterize reproducibility of patient breath-hold positioning and compare tracking system performance for Deep Inspiration Breath Hold (DIBH) gated left breast radiotherapy.

Methods: 29 consecutive left breast DIBH patients (655 fractions) were treated under the guidance of Calypso surface beacons with audio-feedback and 35 consecutive patients (631 fractions) were treated using C-RAD Catalyst HD surface imaging with audiovisual feedback. The Calypso system tracks a centroid determined by two radio-frequency transponders, with a manually enforced institutional tolerance, while the surface image based CatalystHD system utilizes real-time biometric feedback to track a pre-selected point with an institutional tolerance enforced by the Elekta Response gating interface. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.025DOI Listing

Implementing safe and robust Total Marrow Irradiation using Helical Tomotherapy - A practical guide.

Phys Med 2019 Apr 6;60:162-167. Epub 2019 Apr 6.

Department of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.

Total Marrow Irradiation (TMI) with Helical Tomotherapy is a radiotherapy treatment technique that targets bone marrow and sanctuary sites prior to stem cell or bone marrow transplantation (SCT/BMT). TMI is a complex procedure that involves several critical steps that all need to be carefully addressed for a successful implementation, such as dose homogeneity in field junctions, choice of target margins, integrity of treatment and back-up planning. In this work we present our solution for a robust and reproducible workflow throughout the treatment chain and data for twenty-three patients treated to date. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.032DOI Listing

An in silico planning study comparing doses and estimated risk of toxicity in 3D-CRT, IMRT and proton beam therapy of patients with thymic tumours.

Phys Med 2019 Apr 30;60:120-126. Epub 2019 Mar 30.

Department of Oncology, Södersjukhuset, Stockholm, Sweden; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.

Purpose: To compare the dose distributions produced in patients (pts) treated for thymic tumours with spot-scanning proton beam therapy (PBT) implemented with single-field uniform dose (SFUD), intensity-modulated radiation therapy (IMRT) and three-dimensional conformal photon-beam based radiotherapy (3D-CRT).

Methods: Twelve pts, treated with 3D-CRT, were included. Alternative IMRT and SFUD plans were constructed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797193007
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http://dx.doi.org/10.1016/j.ejmp.2019.03.028DOI Listing
April 2019
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Evaluating out-of-field doses during radiotherapy of paediatric brain tumours using lead shielding and flattening-filter free beams.

Phys Med 2019 Apr 20;60:1-6. Epub 2019 Mar 20.

Aarhus University Hospital, Department of Oncology, Palle Juul-Jensens Blvd. 99, DK-8200 Aarhus, Denmark.

Paediatric radiotherapy comes at the expense of increased risk of late effects due to out-of-field dose caused not only by the treatment itself but also by image guidance. This study examined how the out-of-field dose to selected radiosensitive organs was affected by applying a 1 mm lead shielding during delivery of volumetric-modulated arc therapy (VMAT) for paediatric brain cancer. The study also investigated how the out-of-field dose to the same organs was affected by the use of flattening-filter free (FFF) beams. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.008DOI Listing

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells.

J Immunother Cancer 2019 Apr 18;7(1):109. Epub 2019 Apr 18.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.

Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a tumor-specific immune response. DC vaccination remains a promising approach with the potential to further improve cancer immunotherapy with little or no evidence of treatment-limiting toxicity. Read More

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http://dx.doi.org/10.1186/s40425-019-0580-6DOI Listing

Comparison of Proton and Photon Beam Irradiation in Radiation-Induced Intestinal Injury Using a Mouse Model.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.

When radiotherapy is applied to the abdomen or pelvis, normal tissue toxicity in the gastrointestinal (GI) tract is considered a major dose-limiting factor. Proton beam therapy has a specific advantage in terms of reduced doses to normal tissues. This study investigated the fundamental differences between proton- and X-ray-induced intestinal injuries in mouse models. Read More

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http://dx.doi.org/10.3390/ijms20081894DOI Listing

The potential of photon-counting CT for quantitative contrast-enhanced imaging in radiotherapy.

Phys Med Biol 2019 Apr 18. Epub 2019 Apr 18.

Physique, Université de Montréal, Montréal, Quebec, CANADA.

The aim of this study is to use a simulation environment to evaluate the potential of using photon-counting CT (PCCT) against dual-energy CT (DECT) in the context of quantitative contrast-enhanced CT for radiotherapy. An adaptation of Bayesian eigentissue decomposition by Lalonde (2017 <i>Med. Phys. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1af1
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http://dx.doi.org/10.1088/1361-6560/ab1af1DOI Listing
April 2019
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Radical chest wall resection and modified reconstruction technique for solitary internal mammary lymph node recurrence in breast cancer.

Int J Surg Case Rep 2019 Apr 6;58:26-29. Epub 2019 Apr 6.

Department of Thoracic Surgery and Oncology, King Fahad Specialist Hospital Dammam, Saudi Arabia.

Introduction: Although the incidence of internal mammary lymph node recurrence rate in breast cancer is low but still it is the second most common drainage site after axilla. Patients with solitary internal mammary lymph node (IMLN) recurrence have overall better prognosis. The role of chemo and radiotherapy in internal mammary lymph node involvement with breast cancer is still controversial. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.021DOI Listing

Radiation-Induced Lung Injury: Assessment and Management.

Chest 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiation Oncology, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston TX, USA.

Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation therapy (RT) and manifests acutely as radiation pneumonitis (RP) and chronically as radiation pulmonary fibrosis (RPF). Since most patients with thoracic and breast malignancies are expected to undergo RT in their lifetime, many with curative intent, the population at risk is significant. Further, indications for thoracic RT are expanding given the advent of stereotactic body radiation therapy or stereotactic ablative radiotherapy (SBRT/SABR) for early stage lung cancer in non-surgical candidates as well as oligometastatic pulmonary disease from any solid tumor. Read More

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http://dx.doi.org/10.1016/j.chest.2019.03.033DOI Listing
April 2019
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Radiation induces changes in toll-like receptors of the uterine cervix of the rat.

PLoS One 2019 18;14(4):e0215250. Epub 2019 Apr 18.

Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Radiotherapy is an important therapeutic approach against cervical cancer but associated with adverse effects including vaginal fibrosis and dyspareunia. We here assessed the immunological and oxidative responses to cervical irradiation in an animal model for radiation-induced cervicitis. Rats were sedated and either exposed to 20 Gy of ionising radiation given by a linear accelerator or only sedated (controls) and euthanized 1-14 days later. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215250PLOS
April 2019
3 Reads