339,371 results match your criteria Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology[Journal]


Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database.

J Neurosurg 2019 Feb 15:1-12. Epub 2019 Feb 15.

1The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston McGovern Medical School.

OBJECTIVEThe present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment.METHODSBased on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182247DOI Listing
February 2019

Outcomes of decompressive surgery for cavernous sinus meningiomas: long-term follow-up in 50 patients.

J Neurosurg 2019 Feb 15:1-8. Epub 2019 Feb 15.

1Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; and.

OBJECTIVECavernous sinus meningiomas are complex tumors that offer a perpetual challenge to skull base surgeons. The senior author has employed a management strategy for these lesions aimed at maximizing tumor control while minimizing neurological morbidity. This approach emphasizes combining "safe" tumor resection and direct decompression of the roof and lateral wall of the cavernous sinus as well as the optic nerve. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181480DOI Listing
February 2019

Risk factors for pelvic and distant recurrence in locally advanced cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:6-12. Epub 2019 Feb 6.

Medical Oncology Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil. Electronic address:

Objective: Despite the benefits of concomitant radiotherapy and cisplatin for locally advanced cervical cancer, recurrence rates remain high. New treatment strategies such as consolidation chemotherapy and different concomitant chemotherapy combinations have been tested in recent years. Identification of the best candidates for each treatment strategy could optimize results. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.028DOI Listing
February 2019

Metformin Induces Human Esophageal Carcinoma Cell Pyroptosis by Targeting the miR-497/PELP1 Axis.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Institute of Precision Cancer Medicine and Pathology, And Department of Pathology, Jinan University Medical College, Guangzhou, China; Department of Immunotherapy and Tumor Tissue Bank, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. Electronic address:

Evasion of apoptosis is a major contributing factor to the development of chemo- and radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death (PCD) could be an effective alternative against apoptosis-resistant cancers. In this study, we demonstrated in vitro and in vivo that metformin can induce pyroptosis, a non-apoptotic PCD, in esophageal squamous cell carcinoma (ESCC), a commonly known chemo-refractory cancer, especially at its advanced stages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193008
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http://dx.doi.org/10.1016/j.canlet.2019.02.014DOI Listing
February 2019
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Experts' Consensus on Intraoperative Radiotherapy for Pancreatic Cancer.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

National Cancer Center, China and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address:

Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8% to 10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. However, only 20% of patients have the opportunity to undergo surgical operation. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.038DOI Listing
February 2019

Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address:

Rhabdomyosarcoma (RMS) is a pediatric soft tissue tumor classified in two major subtypes namely embryonal and alveolar, which have distinctive histopathological and genetic signatures and worse outcomes in the presence of metastases. Here, in order to evaluate the role of Caveolin-1 (Cav-1) in embryonal RMS dissemination, we employed an experimental in vivo metastasis assay using immunodeficient NOD/SCID mice. We found that the intravenous injection of human RD cells engineered for Cav-1 overexpression promoted the formation of lung metastases compared to parental cells. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.013DOI Listing
February 2019

Concomitant radiotherapy and TKI in metastatic EGFR- or ALK-mutated non-small cell lung cancer: a multicentric analysis on behalf of AIRO lung cancer study group.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Oncology Radiation Therapy Unit, Careggi University Hospital, Florence, Italy.

Purpose: To investigate the role of radiotherapy (RT) in the management of EGFR- or ALK-mutated metastatic non-small cell lung cancer (NSCLC) treated with TKI.

Materials And Methods: Clinical data of 106 patients (pts) from five Institutions treated with RT concomitant to TKI were retrospectively revised. Overall survival (OS) and toxicities were analyzed as endpoints of the study. Read More

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http://dx.doi.org/10.1007/s11547-019-00999-wDOI Listing
February 2019

Postoperative Treatment of Oropharyngeal Cancer in the Era of Human Papillomavirus.

Curr Treat Options Oncol 2019 Feb 15;20(3):20. Epub 2019 Feb 15.

Department of Head and Neck Oncologic Surgery, Head and Neck Institute, Cleveland Clinic, 9500 Euclid Avenue, A-71, Cleveland, OH, 44195, USA.

Opinion Statement: Despite an overall decline in the incidence of tobacco-related cancers, human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) of the oropharynx is on the rise. The prognosis of HPV-related oropharynx cancer (HPV-OPC) is generally favorable even in locoregionally advanced disease, and a variety of treatment options are available. Though the primary treatment modality of choice remains definitive radiation (RT), surgical resection followed by appropriate adjuvant therapy remains an option, especially in those patients who may not be favorable candidates for definitive radiotherapy, particularly when concurrent chemotherapy is warranted. Read More

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http://dx.doi.org/10.1007/s11864-019-0620-yDOI Listing
February 2019

SCMCIE94: an intensified pilot treatment protocol known to be associated with cure in CD 56-negative non-pelvic isolated Ewing sarcoma (EWS) is also associated with no early relapses in non-metastatic extremity EWS.

Cancer Chemother Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

The Rina Zaizov Hematology-Oncology Division, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Purpose: We report the unexpected absence of early relapse (before 30 months) in 24 consecutive patients with isolated limb primary Ewing sarcoma treated with an intensified pilot protocol, SCMCIE94.

Methods: Clinical data for the study were collected retrospectively from the patient files. The protocol included 6 courses of chemotherapy, split radiation, and limb salvage surgery. Read More

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http://dx.doi.org/10.1007/s00280-019-03789-3DOI Listing
February 2019

PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.

Cell Death Dis 2019 Feb 15;10(3):156. Epub 2019 Feb 15.

Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, 01812, Korea.

Current lung cancer treatments are far from satisfactory; thus, finding novel treatment targets is crucial. We recently identified procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3), which is involved in fibrosis and tissue remodeling as a radioresistance-related protein in lung cancer cells; however, its mechanism is unclear. In this study, we designed human PLOD3-specific short interfering (si)RNAs and tested their effects on tumor growth inhibition in vitro and in vivo. Read More

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http://dx.doi.org/10.1038/s41419-019-1405-8DOI Listing
February 2019

EVI1 promotes epithelial-to-mesenchymal transition, cancer stem cell features and chemo-/radioresistance in nasopharyngeal carcinoma.

J Exp Clin Cancer Res 2019 Feb 15;38(1):82. Epub 2019 Feb 15.

Department of Radiotherapy, People's Hospital of Shanxi Province, Taiyuan, China.

Background: Aberrant EVI1 expression is frequently reported in cancer studies; however, its role in nasopharyngeal carcinoma (NPC) has not been examined in detail. The aim of the present study is to investigate the involvement of EVI1 in progression and prognosis of NPC.

Methods: RT-PCR, immunohistochemistry and western blot assays were used to examine the expression of EVI1 in NPC tissues and cell lines. Read More

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http://dx.doi.org/10.1186/s13046-019-1077-3DOI Listing
February 2019

Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous.

Radiat Oncol 2019 Feb 15;14(1):33. Epub 2019 Feb 15.

Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA.

Background: Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ trial now influence the decision to recommend or withhold WBRT for patients with unfavorable prognosis, and similarly, for favorable prognosis patients, the balance between radiosurgery alone or WBRT has become a nuanced decision. Read More

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http://dx.doi.org/10.1186/s13014-019-1237-9DOI Listing
February 2019

Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients.

BMC Cancer 2019 Feb 15;19(1):155. Epub 2019 Feb 15.

Department of Oral and Maxillofacial Plastic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str, 40 06097, Halle/Saale, Germany.

Background: The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5FL) in progression and prognosis of several cancers was reported. However, the biological function of three splice variants of LGR5 (LGR5Δ5, LGR5Δ8 and LGR5Δ5-8) has yet to be thoroughly investigated. Read More

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http://dx.doi.org/10.1186/s12885-019-5327-8DOI Listing
February 2019

[Application Status and Development Trends of Medical Proton and Heavy Ion Accelerators].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):37-42

School of Mechanical and Electronical Engineering, Lanzhou University of Technology, Lanzhou, 730050.

Cancer therapy with accelerated proton or heavy ion beam is the most advanced radiotherapy technology, which is recognized by the international community at present. It is of great practical significance to study the medical proton and heavy ion accelerators and the radiotherapy technology, in order to promote the development of the advanced medical radiotherapy equipments and improve the quality of life of cancer patients in China. After a brief overview of cancer therapy with proton and heavy ion beam, this paper summarized and analyzed the application status of medical proton accelerators and medical heavy ion accelerators at home and abroad, and finally put forward the future development trends of medical proton and heavy ion accelerators and the radiotherapy technology, it can provide a reference for the progress and development strategies of the advanced radiotherapy equipments in China. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.010DOI Listing
January 2019

[Design and Implementation of Automated QA Software for Cone Beam CT Image].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):25-28

Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, 230031.

In order to improve the speed and accuracy of cone beam CT image quality assurance, an automatic image quality assurance software based on feature extraction is designed and implemented. This paper introduces how the software can realize the positioning of Catphan500 phantoms and the selection of ROI in each module through Canny algorithm and Hough transform circle detection. For the different modules in the Catphan500 phantom, this paper describes the calculation methods of HU accuracy, spatial linearity, HU uniformity and spatial linearity in the software. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.007DOI Listing
January 2019

Active surveillance for nodular lymphocyte-predominant Hodgkin lymphoma.

Blood 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of lymphoma that, like other Hodgkin lymphomas, has historically been treated aggressively. However, in most cases, NLPHL has an indolent course, which raises the question to what extent these patients require aggressive upfront treatment. We describe the management and outcomes of consecutive NLPHL patients diagnosed at Memorial Sloan Kettering Cancer Center (MSK), with a focus on evaluating active surveillance. Read More

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http://dx.doi.org/10.1182/blood-2018-10-877761DOI Listing
February 2019

ATM Inhibition Sensitizes Tumors to High-Dose Irradiation.

Authors:
Dennis Hallahan

Cancer Res 2019 Feb;79(4):704-705

Washington University School of Medicine, St. Louis, Missouri.

Mechanistic studies of high-dose irradiation are important to improve our understanding on how the efficacy of stereotactically delivered high-dose irradiation can be enhanced by therapeutics such as ataxia-telangiesctasia-mutated (ATM) inhibitors. In this issue of , Torok and colleagues found that a single 15 Gy radiation dose eliminated lung tumor growth in mice when ATM was deleted in cancer cells versus when deleted in endothelial cells. These data support the establishment of clinical trials testing ATM inhibitors in combination with highly conformal radiotherapy or high-dose rate brachytherapy. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-4072DOI Listing
February 2019

ATR inhibition potentiates the radiation induced inflammatory tumour microenvironment.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Oncology, Institute of Cancer Research.

Purpose: ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitise to chemotherapy and radiotherapy preclinically. No data have been published about the effect of these drugs on the tumor microenvironment.

Experimental Design: We used an immunocompetent mouse model of HPV-driven malignancies to investigate the ATR inhibitor AZD6738 in combination with fractionated radiation (RT). Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1821DOI Listing
February 2019

Time from definitive therapy to onset of metastatic disease predicts outcomes in men with metastatic hormone sensitive prostate cancer.

Urol Oncol 2019 Feb 13. Epub 2019 Feb 13.

Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT. Electronic address:

Purpose: Contemporary treatment for metastatic hormone sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT) plus abiraterone or docetaxel. While these intensified regimens have improved efficacy, they are also associated with increased cost and toxicities. Not all men with mHSPC may be candidates for these intensified regimens, yet there are no clinical models or biomarkers used to optimize treatment selection. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.029DOI Listing
February 2019

Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial.

Lancet Oncol 2019 Feb 12. Epub 2019 Feb 12.

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.

Background: Stereotactic ablative body radiotherapy (SABR) is widely used to treat inoperable stage 1 non-small-cell lung cancer (NSCLC), despite the absence of prospective evidence that this type of treatment improves local control or prolongs overall survival compared with standard radiotherapy. We aimed to compare the two treatment techniques.

Methods: We did this multicentre, phase 3, randomised, controlled trial in 11 hospitals in Australia and three hospitals in New Zealand. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30896-9DOI Listing
February 2019

A tumor board report of an 83-year-old woman with stage IB grade 3 endometrioid endometrial adenocarcinoma.

Curr Probl Cancer 2019 Feb 7. Epub 2019 Feb 7.

Brigham and Women's Hospital, Department of Gynecologic Oncology, Boston, Massachusetts; Dana Farber Cancer Institute, Department of Gynecologic Oncology, Boston, Massachusetts.

An 83-year-old woman presented with postmenopausal bleeding ultimately leading to surgery and a final diagnosis of stage IB grade 3 endometrioid endometrial adenocarcinoma. The tumor board reviewed current literature regarding the efficacy of sentinel lymph node dissection in appropriately allocating stage in high-grade endometrial cancer. The optimal role of adjuvant treatment in this setting is unclear. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2019.01.006DOI Listing
February 2019

[General practitioner questionnaire concerning upper limb lymphedema after breast cancer].

Authors:
M Simon S Vignes

J Med Vasc 2019 Feb 20;44(1):3-8. Epub 2018 Dec 20.

Unité de Lymphologie, site constitutif du Centre national de référence des maladies vasculaires rares (lymphœdèmes primaires), hôpital Cognacq-Jay, 15, rue Eugène-Millon, 75015 Paris, France. Electronic address:

Introduction: In France, breast cancer is the most frequent cancer in women. Lymphedema, the main complication, is poorly known. The objective of this study was to assess the state of knowledge of upper limb lymphedema (risk factors, complications, treatment) after treatment of breast cancer among general practitioners from the Haute-Normandie and Île-de-France regions. Read More

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http://dx.doi.org/10.1016/j.jdmv.2018.11.004DOI Listing
February 2019

Clear Cell Carcinoma of the Abdominal Wall as a Rare Complication of General Obstetric and Gynecologic Surgeries: 15 Years of Experience at a Large Academic Institution.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology; National Taiwan University Hospital, Taipei 100, Taiwan.

The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. Read More

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http://dx.doi.org/10.3390/ijerph16040552DOI Listing
February 2019

Consensus Statement Supporting the Recommendation for Single-Fraction Palliative Radiotherapy for Uncomplicated, Painful Bone Metastases.

Fed Pract 2016 May;33(Suppl 4):16S-22S

and are both attending physicians at the James J. Peters VAMC in Bronx, New York. is an attending physician, and is the national director of the VHA Radiation Oncology program, both at the Hunter Holmes McGuire VAMC, in Richmond, Virginia. is an attending physician at the Washington DC VAMC. is the VHA oncology clinical advisor for the Office of Nursing Services, VACO and cancer program director at the Stratton VAMC in Albany, New York. and Dr. Dawson are both attending physicians at the East Orange Campus of the VA New Jersey Health Care System. is an attending physician at the Indianapolis VAMC in Indiana.

Single-fraction palliative radiation therapy is a shorter course treatment option for veterans with terminal cancers and offers effective, convenient pain relief. Read More

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Palliative Radiotherapy for the Management of Metastatic Cancer: Bone Metastases, Spinal Cord Compression, and Brain Metastases.

Fed Pract 2015 May;32(Suppl 4):12S-16S

is a radiation oncologist at the Washington DC VAMC. and are radiation oncologists at the James J. Peters VAMC in the Bronx, New York, and assistant professors at Mount Sinai School of Medicine in New York. and Dr. Dawson are radiation oncologists at the New Jersey VAHCS in East Orange, New Jersey. is a radiation oncologist at the Richard L. Roudebush VAMC in Indianapolis, Indiana. is a radiation oncologist at the Hunter Holmes McGuire VAMC and an assistant professor at Virginia Commonwealth University Massey Cancer Center, both in Richmond, Virginia. is a radiation oncologist at the VA Ann Arbor HCS in and an associate professor at the University of Michigan, Ann Arbor.

Life expectancy and tumor characteristics should be considered when making treatment recommendations for palliative radiotherapy, which can be cost-effective and provide symptom relief. Read More

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Role of radiotherapy in the management of acromegaly.

Expert Rev Endocrinol Metab 2006 May;1(3):449-460

e Leiden University Medical Center, Departments of Endocrinology and Metabolism, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Active acromegaly can be treated effectively by transsphenoidal surgery, radiotherapy and medical treatment in the form of somatostatin analogs and growth hormone receptor antagonists. Many patients will require a combination of treatment modalities to normalize growth hormone excess and associated increased mortality, and to improve comorbidity. Following postoperative radiotherapy, growth hormone and insulin-like growth factor-I levels gradually decrease and normalization of growth hormone and insulin-like growth factor-I is achieved in 50% of patients after 5 years and 75% after 10 years. Read More

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http://dx.doi.org/10.1586/17446651.1.3.449DOI Listing

Management of neuroendocrine tumors: current and future therapies.

Authors:
Kjell E Öberg

Expert Rev Endocrinol Metab 2011 Jan;6(1):49-62

a Department of Endocrine Oncology, University Hospital, Uppsala University, Department of Medical Sciences, SE-751 85 Uppsala, Sweden.

Neuroendocrine tumors (NETs) are a genetically diverse group of malignancies that sometimes produce peptides that cause characteristic hormonal syndromes. NETs can be clinically symptomatic (functioning) or silent (nonfunctioning); both types frequently synthesize more than one peptide, although often these are not associated with specific syndromes. Based on data from various sources, the incidence and prevalence of NETs is increasing. Read More

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http://dx.doi.org/10.1586/eem.10.81DOI Listing
January 2011

Intraindividual comparison of selective intraarterial versus systemic intravenous 68Ga-DOTATATE PET/CT in patients with inoperable meningioma.

Nuklearmedizin 2019 Feb 15;58(1):23-27. Epub 2019 Feb 15.

Department of Diagnostic and Interventional Neuroradiology, RWTH University Hospital Aachen.

Aim: Here we describe the results of superselective intraarterial application of diagnostic Ga-68-DOTA0,Tyr3-octreotate (Ga-68-DOTATATE) in a series of patients with inoperable WHO grade II meningiomas which were no longer amenable to radiotherapy.

Methods: Four patients with inoperable WHO grade II meningioma underwent systemic venous infusion of Ga-68-DOTATATE followed by PET/CT. Ga-68-DOTATATE application was repeated intraarterially via transfemoral catheterization of vessels supplying the meningioma and another PET/CT was performed. Read More

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http://dx.doi.org/10.1055/a-0802-5039DOI Listing
February 2019

Influence of 18F-FDG-PET/CT on staging of cervical cancer.

Nuklearmedizin 2019 Feb 15;58(1):17-22. Epub 2019 Feb 15.

Chair and Department of Electroradiology, Poznan University of Medical Science.

Aim: Cervical cancer is one of the most common cancers of the female reproductive system. The aim of the study was to assess the usefulness of the F-FDG-PET/CT study in staging of cervical cancer, with focus on the primary tumor parameters.

Material & Methods: 105 patients (mean age 56 ± 11y) with newly diagnosed cervical cancer underwent PET/CT examination which was performed 60 min after IV injection of F-FDG with a mean activity of 364 ± 75MBq. Read More

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http://dx.doi.org/10.1055/a-0809-4577DOI Listing
February 2019

Hyperthyroidism Following Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Int J Radiat Oncol Biol Phys 2019 Feb 12. Epub 2019 Feb 12.

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.

Background: The association of hyperthyroidism with exposure to ionizing radiation is poorly understood. This study addresses the risk of hyperthyroidism in relation to incidental therapeutic radiation dose to the thyroid and pituitary glands in a large cohort of survivors of childhood cancer.

Methods: Utilizing the Childhood Cancer Survivor Study, a cohort of five-year survivors of childhood cancer diagnosed at hospitals in the United States and Canada between 1970 and 1986, the occurrence of hyperthyroidism through 2009 was ascertained among 12,183 survivors based on serial questionnaires. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193020
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http://dx.doi.org/10.1016/j.ijrobp.2019.02.009DOI Listing
February 2019
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Association between primary language, a lack of mammographic screening, and later stage breast cancer presentation.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.

Background: Health determinants are known to influence the stage of breast cancer presentation, but it is unclear to what extent language affects stage. This study investigates whether non-English-speaking (NES) patients present at a later stage than their English-speaking (ES) counterparts and whether language is associated with mammographic screening.

Methods: This study was a retrospective, single-institution cohort analysis of women undergoing breast radiotherapy from 2012 to 2017 (n = 1057). Read More

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http://dx.doi.org/10.1002/cncr.32027DOI Listing
February 2019

Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Posterior fossa ependymoma (PFE) comprises 2 groups, PF group A (PFA) and PF group B (PFB), with stark differences in outcome. However, to the authors' knowledge, the long-term outcomes of PFA ependymoma have not been described fully. The objective of the current study was to identify predictors of survival and neurocognitive outcome in a large consecutive cohort of subgrouped patients with PFE over 30 years. Read More

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http://dx.doi.org/10.1002/cncr.31995DOI Listing
February 2019

Risk Assessment After a Severe Hospital-Acquired Infection Associated With Carbapenemase-Producing Pseudomonas aeruginosa.

JAMA Netw Open 2019 Feb 1;2(2):e187665. Epub 2019 Feb 1.

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.

Importance: Resistance of gram-negative bacilli to carbapenems is rapidly emerging worldwide. In 2016, the World Health Organization defined the hospital-built environment as a core component of infection prevention and control programs. The hospital-built environment has recently been reported as a source for outbreaks and sporadic transmission events of carbapenemase-producing gram-negative bacilli from the environment to patients. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.7665DOI Listing
February 2019

Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study.

Clin Exp Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Medical Research Ctr.of Orthopaedics, Chinese Academy of Medical Sciences; Beijing Key Lab. for Genetic Res.of Skeletal Deformity; Dept.of Central Laboratory, Peking Union Medical College Hosp., Peking Union Med. College and Chinese Academy of Med.Science.

Objectives: To evaluate the clinical efficacy of bisphosphonates treatment for spinal bone marrow oedema (BME) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.

Methods: SAPHO syndrome patients presenting to Peking Union Medical College Hospital from 2015 to 2016 were recruited. Patients were administered pamidronate disodium 1 mg/kg/d intravenously, for 3 days, at baseline and 3 months later. Read More

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February 2019

Cryopreserved amniotic membrane and umbilical cord for a radiation-induced wound with exposed dura: a case report.

Authors:
David Fernandez

J Wound Care 2019 Feb;28(Sup2):S4-S8

Florida Hospital Orlando, Orlando, US.

An 87-year old male received surgical excision of scalp melanoma and subsequent radiotherapy due to metastasis to the skull. A radiation-induced wound developed with osteoradionecrosis that required necrotic bone excision resulting in a 7.5x8. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.Sup2.S4DOI Listing
February 2019

The Effect of Platelet-Rich Plasma on the Temporomandibular Joint After Radiotherapy in Rabbits.

Ann Otol Rhinol Laryngol 2019 Feb 15:3489419830121. Epub 2019 Feb 15.

1 Department of Otorhinolaryngology, University of Health Sciences Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.

Objectives:: Platelet-rich plasma (PRP) was administered into the temporomandibular joint (TMJ) space, which had been exposed to radiotherapy (RT), in an attempt to prevent and/or treat the late-term complications associated with RT when used for the treatment of head and neck cancers (nasopharyngeal cancer in particular) on the musculoskeletal system.

Methods:: A total of 13 adult male New Zealand ( Oryctolagus cuniculus) rabbits were used in the study. The animals were classified into 3 groups: 6 in the RT group, 6 in the RT+PRP group, and 1 in the control group (exposed to neither). Read More

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http://journals.sagepub.com/doi/10.1177/0003489419830121
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http://dx.doi.org/10.1177/0003489419830121DOI Listing
February 2019
3 Reads

Incidence, features and management of radionecrosis in melanoma patients treated with cerebral radiotherapy and anti-PD-1 antibodies.

Pigment Cell Melanoma Res 2019 Feb 15. Epub 2019 Feb 15.

Melanoma Institute Australia and The University of Sydney, Sydney, Australia.

Background: Brain radiotherapy is used in the management of melanoma brain metastases (MBM), and can result in radionecrosis. Anti-PD-1 is active in the brain and may increase the risk of radionecrosis when combined with radiotherapy. We studied the incidence, associated factors and management of radionecrosis in longer-term survivors with MBM treated with this combination. Read More

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http://dx.doi.org/10.1111/pcmr.12775DOI Listing
February 2019

Critical review of the management of primary central nervous nongerminomatous germ cell tumors.

Pediatr Blood Cancer 2019 Feb 15:e27658. Epub 2019 Feb 15.

The Division of Hematology, Oncology and Blood and Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.

Multimodal strategies have significantly improved the outcomes for patients with central nervous system nongerminomatous germ cell tumors. Two large cooperative group studies have recently reported much improved outcomes compared with historical series. However, a substantial proportion of patients still attain inadequate responses to initial chemotherapy prior to irradiation, with adverse impact upon survival; optimal induction chemotherapy regimens and radiotherapy strategies are as yet unidentified. Read More

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http://dx.doi.org/10.1002/pbc.27658DOI Listing
February 2019

Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide-loaded PLGA microparticles for the treatment of glioblastoma.

J Biomed Mater Res B Appl Biomater 2019 Feb 15. Epub 2019 Feb 15.

Department of Health and Biomedical Sciences, University of Texas Rio Grande Valley, One West University Blvd., Brownsville, Texas, 78520.

Glioblastoma multiforme (GBM) is the most common and invasive form of malignant brain tumors and despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with GBM still remains poor. Temozolomide (TMZ) is the chemotherapy drug that is most commonly given orally after surgical resection of these tumors. In this study, the effects of solvents (i. Read More

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http://dx.doi.org/10.1002/jbm.b.34324DOI Listing
February 2019
1 Read

Extended surgical safety margins and ulceration are associated with an improved prognosis in pleomorphic dermal sarcomas (PDS).

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Background: Pleomorphic dermal sarcomas (PDS) are frequent UV-induced sarcomas of the skin of intermediate grade malignant potential. Despite the fact that PDS have a noteworthy potential to recur (up to 28%) as well as to metastasize (up to 20%), there are no specific clinical guidelines with respect to follow-up these patients. Moreover, little is known about clinical, histological or molecular prognostic factors in PDS. Read More

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http://dx.doi.org/10.1111/jdv.15493DOI Listing
February 2019

Fractionated ionizing radiation facilitates interferon-γ signaling and anticancer activity in lung adenocarcinoma cells.

J Cell Physiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Fractionated ionizing radiation (FIR) is a radiotherapy regimen that is regularly performed as part of lung cancer treatment. In contrast to the growth inhibition caused by DNA damage, immunomodulation in post-irradiated cancer cells is not well documented. Interferon (IFN)-γ confers anticancer activity by triggering both growth inhibition and cytotoxicity. Read More

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http://dx.doi.org/10.1002/jcp.28258DOI Listing
February 2019

Simultaneous Radiological and Fiberendoscopic Evaluation of Swallowing ("SIRFES") in Patients After Surgery of Oropharyngeal/Laryngeal Cancer and Postoperative Dysphagia.

Dysphagia 2019 Feb 14. Epub 2019 Feb 14.

Division of Phoniatrics-Logopedics, Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

To compare the results of a simultaneously performed videofluoroscopic swallowing study and fiberendoscopic evaluation of swallowing in patients with dysphagia after surgery and radiotherapy for oropharyngeal or laryngeal cancer. This prospective study included 31 patients who were examined simultaneously with a standardized protocol. The fiberendoscopic and videofluoroscopic swallowing loops were independently scored by two otorhinolaryngologists/phoniatricians and two radiologists. Read More

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http://dx.doi.org/10.1007/s00455-019-09979-8DOI Listing
February 2019

[Local radiotherapy for patients with newly diagnosed, metastatic prostate cancer].

Strahlenther Onkol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiation Oncology, Competence Center Palliative Care, University Hospital Zurich (USZ), Rämistrasse 100, 8091, Zurich, Schweiz.

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http://dx.doi.org/10.1007/s00066-019-01435-8DOI Listing
February 2019

Senescence and Cancer.

Cancer Transl Med 2018 May-Jun;4(3):70-74. Epub 2018 Jun 29.

Department of Microbiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.

Senescence is a double-edged sword that can function in opposite directions. It is a potential mechanism for a cell to avoid malignant transformation. However, senescence can also promote cancer development by altering the cellular microenvironment through a senescence-associated secretory phenotype (SASP). Read More

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http://dx.doi.org/10.4103/ctm.ctm_22_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372122PMC
June 2018
1 Read

The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx.

Biomed Res Int 2019 15;2019:8142572. Epub 2019 Jan 15.

Department for Otolaryngology and Head and Neck Surgery, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.

The aim of study was to investigate the expression of the proliferation factor Ki-67 and its relationship with histological grade, cancer stage, and treatment outcome in squamous cell carcinoma of the larynx. Samples from 78 patients with laryngeal cancer were analysed retrospectively. Paraffin sections of tumors were immunohistochemically stained for Ki-67 expression. Read More

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http://dx.doi.org/10.1155/2019/8142572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350589PMC
January 2019

Conventional radiotherapy and intensity-modulated radiotherapy in carcinoma vulva: An experience from a tertiary medical center of India.

South Asian J Cancer 2019 Jan-Mar;8(1):41-43

Department of Radiotherapy and Oncology, Postgraduate Medical Education and Research, Chandigarh, India.

Context: Vulvar cancer is one of the uncommon gynecological malignancies. Multimodality treatment with surgery, radiotherapy, and chemotherapy are required for treatment of the disease.

Aims: The aim of the study was to evaluate clinical outcome in patients of carcinoma vulva, treated at our institution. Read More

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http://dx.doi.org/10.4103/sajc.sajc_66_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348779PMC
February 2019

Mucosal melanoma of the head-and-neck region: A single institutional clinical experience.

South Asian J Cancer 2019 Jan-Mar;8(1):26

Department of Radiotherapy, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

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http://dx.doi.org/10.4103/sajc.sajc_326_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348772PMC
February 2019

Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):793-797

Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.

Introduction: Anaplastic thyroid cancers (ATCs) usually present in the sixth to seventh decades of life and little is known about the disease in young patients. The aim was to analyze the clinicopathological characteristics diagnosed with ATC in an iodine-deficient area.

Material And Methods: The medical records of 100 patients diagnosed with ATC at a tertiary care hospital between 1991 and 2013 were reviewed. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_264_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330874PMC
February 2019

Risk factors and clinical characteristics of Pneumocystis jirovecii pneumonia in lung cancer.

Sci Rep 2019 Feb 14;9(1):2094. Epub 2019 Feb 14.

Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Solid malignancies are associated with the development of Pneumocystis jirovecii pneumonia (PJP). This study aimed to evaluate the risk factors for PJP among patients with lung cancer. This retrospective case-control study compared patients who had lung cancer with PJP (n = 112) or without PJP (n = 336) matched according to age, sex, histopathology, and stage. Read More

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http://www.nature.com/articles/s41598-019-38618-3
Publisher Site
http://dx.doi.org/10.1038/s41598-019-38618-3DOI Listing
February 2019
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Predictive factors of prognosis after radiation and steroid pulse therapy in thyroid eye disease.

Sci Rep 2019 Feb 14;9(1):2027. Epub 2019 Feb 14.

Department of Radiology, Aichi Medical University Hospital, Aichi, Japan.

To identify predictive factors of prognosis after radiotherapy with concurrent steroid pulse therapy for thyroid eye disease, retrospective analyses were performed among 77 patients. Clinical activity score and magnetic resonance imaging were used to evaluate degrees of orbital inflammation. As a pre-treatment work-up, the thyroid-stimulating antibody (TSAb) level was measured. Read More

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http://dx.doi.org/10.1038/s41598-019-38640-5DOI Listing
February 2019