336,705 results match your criteria Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology[Journal]


Prognosis of renal cell carcinoma with bone metastases: Experience from a large cancer centre.

Eur J Cancer 2018 Dec 11;107:79-85. Epub 2018 Dec 11.

Department of Cancer Medicine, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France.

Background: Bone metastases (BMs) are associated with significant morbidity and shorter survival in renal cell carcinoma (RCC). Our purpose was to identify prognostic factors for overall survival (OS) in RCC patients with BMs.

Methods: Data from patients with BMs from RCC treated at Gustave Roussy between April 1992 and March 2016 were retrospectively collected. Read More

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December 2018

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 Dec 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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December 2018

[Advances in osteoradionecrosis of nasopharynx after radiotherapy for nasopharyngeal carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1839-1842

Radiation therapy is the first choice for the treatment of nasopharyngeal carcinoma. However, it is inevitable that nasopharyngeal mucosa and tissue will be damaged after radiotherapy of nasopharyngeal carcinoma, which will cause corresponding complications. Nasopharyngeal osteonecrosis is a serious complication. Read More

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December 2018
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[Analysis of distant metastasis and related factors of head and neck mucosal melanoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1078-1081

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100010, China.

To analyze the characteristics and related factors of distant metastasis of head and neck mucosal melanoma, so as to provide better help for the treatment and the control of patients' survival. Retrospectively analyze the patients of head and neck mucosal melanoma who were treated in our hospital from January 2004 to December 2016, through follow-up, of which 37 cases of patients with metastatic disease were analyzed which including the incidence of distant metastasis, specific metastasis and prognosis, time, etc.The age and gender of the patients were controlled, and 37 cases of 1∶1 were selected randomly in the patients who had no distant metastasis. Read More

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[Preliminary experience of transoral robotic surgery in laryngeal and hypopharyngeal tumors with da Vinci surgical system].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1065-1070

Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

The purpose of this study was to summarize preliminary clinical experience of transoral robotic surgery (TORS) in laryngeal and hypopharyngeal tumors with da Vinci surgical system.Twelve patients were reviewed who were diagnosed with laryngeal (=7) and hypopharyngeal tumors (=5) and treated with TORS in Beijing Anzhen Hospital from July 1, 2016 to January 31, 2018.Ten cases were male and two cases were female. Read More

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[Robotic nasopharyngectomy via combined approach of noseand oral for local recurrent nasopharyngeal carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1048-1050;1055

Department of Otolaryngology, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, 510120, China.

Surgery is one of the salvage treatments for recurrent nasopharyngeal carcinoma. The safety and efficacy of Da Vinci's robotic surgery was preliminarily investigated to resect recurrent nasopharyngeal cancer after one-course radiotherapy.Since Oct 2017, Da Vinci surgery system was used to complete the operation of locally recurrent nasopharyngeal carcinoma including two approaches, such as trans oral with soft palate incision and trans oral and nose with soft palate suspended. Read More

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Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer.

Small 2018 Dec 14:e1804191. Epub 2018 Dec 14.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, P. R. China.

Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo-radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Read More

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December 2018

An update on the management and outcomes of cancer patients with severe aortic stenosis.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Objectives: We compared the outcomes of aortic valve replacement (AVR) by transcatheter (TAVR) and surgical (SAVR) routes with those of optimal medical management in patients with cancer and severe aortic stenosis (AS).

Background: Cancer therapy requires optimal cardiac output; however, the treatment of AS in cancer patients is not established.

Methods: Cancer patients with severe AS during January 2009 through February 2018 at a large cancer center were identified. Read More

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December 2018
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Contemporary management of primary parapharyngeal space tumors.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Coordinator of the International Head and Neck Scientific Group.

The parapharyngeal space is a complex anatomical area. Primary parapharyngeal tumors are rare tumors and 80% of them are benign. A variety of tumor types can develop in this location; most common are salivary gland neoplasm and neurogenic tumors. Read More

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December 2018

Translation and validation of the MD Anderson Dysphagia Inventory (MDADI) for Spanish-speaking patients.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Otolaryngology Department, Chief of the Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Background: The main objective of this study was to perform the adaptation and cultural translation and validation of the MD Anderson Dysphagia Inventory (MDADI) questionnaire for the Spanish language.

Methods: A total of 69 patients were diagnosed with head and neck cancer treated with surgery; radiotherapy and chemoradiotherapy were included. MDADI was translated and a feasibility, internal consistency, test-retest reliability, and construct validity were assessed. Read More

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December 2018

Impact of cancer service centralisation on the radical treatment of men with high-risk and locally advanced prostate cancer: A national cross-sectional analysis in England.

Int J Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine.

In many countries, specialist cancer services are centralised to improve outcomes. We explored how centralisation affects the radical treatment of high-risk and locally advanced prostate cancer in the English NHS. 79,085 patients diagnosed with high-risk and locally advanced prostate cancer in England (April 2014 to March 2016) were identified in the National Prostate Cancer Audit database. Read More

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December 2018

Cetuximab-radiotherapy combination in the management of locally advanced cutaneous squamous cell carcinoma.

J Med Imaging Radiat Oncol 2018 Dec 14. Epub 2018 Dec 14.

Division of Medical Oncology, Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada.

Introduction: We report the outcomes of using a combination of cetuximab with radiation therapy (Cetux-RT) to treat a selected group of patients with locally advanced (unresectable) cutaneous squamous cell carcinoma (LA-cSCC). This study presents two-year efficacy and safety data for 8 patients with LA-cSCC treated within a single institution.

Methods: Between 2014 and 2017 a total of eight patients (seven males, one female) with LA-cSCC received curative intent treatment with Cetux-RT. Read More

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December 2018

Prognostic value of textural indices extracted from pretherapeutic 18-F FDG-PET/CT in head and neck squamous cell carcinoma.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Nuclear Medicine, Brest University Hospital, Brest, France.

Background: This study aimed at assessing the prognostic value of textural indices extracted from 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)/CT in a large cohort of patients with head and neck squamous cell carcinomas (HNSCC) of any anatomic subsite and staging.

Methods: Consecutive patients with HNSCC referred for a pretreatment FDG-PET/CT were retrospectively included and followed up for a minimum of 2 years. Standardized uptake value, metabolic tumor volume (MTV), and textural indices were calculated using LIFEx software. Read More

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December 2018

Knockdown of DGCR5 enhances the radiosensitivity of human laryngeal carcinoma cells via inducing miR-195.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology, RenMin Hospital of Wuhan University, Wuhan, China.

Long noncoding RNAs (lncRNAs) exert critical roles in the development of various cancers, including human laryngeal cancer. Radioresistance contributes to the predominant causes of laryngeal cancer recurrence after radiotherapy. The aim of our study was to investigate the association of dysregulated lncRNA and radiation resistance in human larynx squamous carcinoma. Read More

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December 2018

Wnt signaling reprograms metabolism in dental pulp stem cells.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Cell Biology and Histology, University of the Basque Country (UPV/EHU), Barrio Sarriena, Leioa, Spain.

Human dental pulp stem cells (DPSCs) can differentiate to a wide range of different cell lineages, and share some gene expression and functional similarities with pluripotent stem cells. The stemness of DPSCs can also be pharmacologically enhanced by the activation of canonical Wnt signaling. Here, we examined the metabolic profile of DPSCs during reprogramming linked to Wnt activation, by a short (48 hr) exposure to either the GSK3-β inhibitor BIO (6-bromoindirubin-3´-oxine) or human recombinant protein WNT-3A. Read More

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December 2018

Association between treatment delays and oncologic outcome in patients treated with surgery and radiotherapy for head and neck cancer.

Head Neck 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: This study sought to determine the oncologic impact of delays to surgery, radiotherapy, and completion of therapy in patients with head and neck squamous cell carcinoma.

Methods: The impact of biopsy to surgery (BTS) time, surgery to start of radiation time (STSR), and radiation treatment time (RTT) on locoregional recurrence (LRR), distant metastases (DMs), and cancer-specific mortality (CSM) was examined. The cumulative incidences (CI) of LRR, DMs, and CSM were examined using Fine-Gray testing. Read More

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December 2018

Definitive radiotherapy versus Mohs surgery for early stage nonmelanoma skin cancers: a multi-institutional retrospective comparison of local recurrence.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA.

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December 2018
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Comparative effectiveness of radiotherapy for early-stage hormone receptor-positive breast cancer in elderly women using real-world data.

Cancer Med 2018 Dec 12. Epub 2018 Dec 12.

Pharmaceutical Outcomes & Policy (POP), College of Pharmacy, University of Florida, Gainesville, Florida.

Background: Radiotherapy is the recommended treatment after breast-conserving surgery (BCS) for early-stage breast cancer (BC). However, there is no clear evidence whether radiotherapy after BCS improves the survival of elderly women diagnosed with early-stage hormone receptor-positive (HR+) BC. The aim of this study was to investigate the survival benefit associated with radiotherapy plus hormonal therapy vs hormonal therapy alone after BCS for early-stage HR+ BC patients. Read More

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December 2018

An effective method to reduce the interplay effects between respiratory motion and a uniform scanning proton beam irradiation for liver tumors: A case study.

J Appl Clin Med Phys 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiation Oncology, New York University Langone Medical Center, Laura and Isaac, Perlmutter Cancer Center, New York, NY, USA.

Purpose: For scanning particle beam therapy, interference between scanning patterns and interfield organ motion may result in suboptimal dose within target volume. In this study, we developed a simple offline correction technique for uniform scanning proton beam (USPB) delivery to compensate for the interplay between scanning patterns and respiratory motion and demonstrate the effectiveness of our technique in treating liver cancer.

Methods: The computed tomography (CT) and respiration data of two patients who had received stereotactic body radiotherapy for hepatocellular carcinoma were used. Read More

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December 2018

Accuracy of fine needle aspiration cytology in suspicious neck nodes after radiotherapy: retrospective analysis of 100 patients.

Clin Otolaryngol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Head and Neck Diseases, Evangelical Hospital Vienna, Vienna, Austria.

Little data are available regarding the accuracy of FNAC performed without ultrasound-guidance in neck nodes after radiotherapy. Our retrospective analysis of 100 patients showed a high sensitivity (87%), specificity (83%), positive predictive value (98%) and accuracy (87%) of this method. Nodal size or lymph node necrosis had no influence on the probability to obtain a diagnostic FNAC. Read More

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December 2018

Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR-197.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Cerebrovascular Disease, Henan Provincial People's Hospital, Zhengzhou, China.

Accumulating studies indicates that circular RNAs (circRNAs) play an imperative role in modulating cancer progression and metastasis. In the previous study, elevated circ_0029426 was first observed in glioblastoma (GBM) tissues compared with normal tissues by circRNA microarray. Our aim is to study the function and mechanism of circ_0029426 in GBM. Read More

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December 2018

Deep learning for patient-specific quality assurance: identifying errors in radiotherapy delivery by radiomic analysis of gamma images with convolutional neural networks.

Med Phys 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, University of Washington, Seattle, WA, USA.

Purpose: Patient-specific quality assurance (QA) for intensity-modulated radiation therapy (IMRT) is a ubiquitous clinical procedure, but conventional methods have often been criticized as being insensitive to errors or less effective than other common physics checks. Recently, there has been interest in the application of radiomics, quantitative extraction of image features, to radiotherapy quality assurance. In this work we investigate a deep learning approach to classify the presence or absence of introduced radiotherapy treatment delivery errors from patient-specific QA. Read More

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December 2018

High-dose versus standard-dose radiation therapy for cervical esophageal cancer: A retrospective single-institution study.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Departments of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE).

Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59. Read More

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December 2018

Evaluation of the theranostic properties of gadolinium-based nanoparticles for head and neck cancer.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Cancer Target and Experimental Therapeutics, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Univ. Grenoble Alpes, Grenoble, France.

Background: The aim of the study was to evaluate the benefits of the combination of Gadolinium-based nanoparticles AGuIX and radiotherapy on the recurrence free survival after tumor resection in a head and neck animal orthotopic model.

Methods: Human head and neck CAL33 orthotopic tumors were implanted in female NMRI nude mice. The biodistribution of AGuIX was studied by fluorescence imaging. Read More

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December 2018

Local immune parameters as potential predictive markers in head and neck squamous cell carcinoma patients receiving induction chemotherapy and cetuximab.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Multidisciplinary Center of Head and Neck Oncology, National Institute of Oncology, Budapest, Hungary.

Background: The aim of this study was to determine whether tumor-associated immune cells may predict response to therapy and disease outcome in head and neck squamous cell carcinoma (HNSCC) patients receiving induction chemotherapy and cetuximab.

Methods: Paraffin-embedded pretreatment biopsy samples from 45 patients with stage III-IV resectable HNSCC were investigated retrospectively by immunohistochemistry for density of different immune cell types based on expression of CD8, FOXP3, CD134, CD137, PD-1, CD20, NKp46, dendritic cell lysosomal-associated membrane protein (DC-LAMP), CD16, CD68, and myeloperoxidase. Results were analyzed for possible correlations with clinicopathologic parameters, response to therapy, and survival. Read More

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December 2018

A retrospective multicenter study of carbon-ion radiotherapy for external auditory canal and middle ear carcinomas.

Cancer Med 2018 Dec 8. Epub 2018 Dec 8.

Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Background: We conducted a retrospective multicenter study to assess the clinical outcomes of carbon-ion radiotherapy (CIRT) for head and neck malignancies (Japan Carbon-Ion Radiation Oncology Study Group [J-CROS] study: 1402 HN). We aimed to evaluate the safety and efficacy of CIRT in patients with external auditory canal (EAC) and middle ear (ME) carcinomas.

Methods: Thirty-one patients treated with CIRT at four Japanese institutions were analyzed. Read More

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December 2018

Oncologic outcomes in prostate cancer patients treated with robot-assisted radical prostatectomy: results from a single institution series with more than 10 years follow up.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, OLV Aalst, Belgium.

Background: Robot-assisted radical prostatectomy (RARP) has gained increasing diffusion as standard of care in the surgical treatment of prostate cancer (PCa) patients, even in the absence of robust long-term oncologic comparative data. To report oncologic outcomes of RARP at more than 10 years follow up.

Methods: We retrospectively evaluated 173 consecutive PCa patients underwent RARP between 2002 and 2005 at a single European center with complete clinic and pathologic data and potential follow up of at least 10 years. Read More

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December 2018

X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells.

J Exp Clin Cancer Res 2018 Dec 14;37(1):315. Epub 2018 Dec 14.

Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA.

Background: Disabled-2 (Dab2) is known as a tumor suppressor as well as a Wnt pathway inhibitor. We previously reported that Dab2 was down-regulated due to gene promoter hypermethylation in lung cancer. Here, we aim to study if X-ray irradiation can induce de-methylation of the Dab2 gene and subsequently up-regulate its expression, and also to attempt to suppress the malignant biological behavior of and enhance the radiosensitivity in lung cancer cells with hypermethylation of the Dab2 gene. Read More

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December 2018

Adoption of prophylactic cranial irradiation (PCI) for extensive stage small cell lung cancer (ES-SCLC): a population based outcome study.

Radiat Oncol 2018 Dec 14;13(1):247. Epub 2018 Dec 14.

Division of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.

Background: The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and after publication of the European RCT and its association with survival in ES-SCLC.

Methods: We identified eligible patients in the only two Singapore national cancer centres from 2003 to 2010. Read More

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December 2018

Endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer: choice of new approach.

Radiat Oncol 2018 Dec 14;13(1):246. Epub 2018 Dec 14.

Department of Radiology, Kyoto Prefectural University Graduate School of Medical Science, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with extended lymph node dissection is highly invasive. Recent reports have shown that endoscopic submucosal dissection (ESD) followed by chemoradiotherapy (CRT) has promising results and might become a new therapeutic approach. Read More

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December 2018

Complete pathological response following neoadjuvant FOLFOX chemotherapy in BRCA2-mutant locally advanced rectal cancer: a case report.

BMC Cancer 2018 Dec 14;18(1):1253. Epub 2018 Dec 14.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Patients with locally advanced rectal cancer (LARC) achieving a pathological complete response (pCR) to neoadjuvant treatment usually have a good prognosis, but only accounted for less than 20%.

Case Presentation: We report a case of a 25-year-old male with LARC treated with neoadjuvant FOLFOX chemotherapy, and experienced a pCR. The next-generation sequencing analysis revealed the presence of breast cancer gene 2 (BRCA2) somatic mutation and an increased somatic mutational load without microsatellite instability (MSI). Read More

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December 2018

Primary pericardial synovial sarcoma: A case report and literature review.

J Cardiol Cases 2014 Jan 13;9(1):40-43. Epub 2013 Dec 13.

Department of Radiotherapy-Oncology, UHC Ibn Rochd, Casablanca, Morocco.

Primary pericardial synovial sarcoma is extremely rare, with few published cases in the literature. We report the case of an adolescent aged 13 years with primary pericardial synovial sarcoma discovered during tamponade, confirmed by molecular biology, and for whom treatment combined radiosurgery and adjuvant chemotherapy. The particularity of the case we are reporting stems from the young age of our patient (13 years) as well as the duration of remission, which is quite long (21 months) prior to a superior mediastinal relapse compared to cases reported in the literature. Read More

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January 2014
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It's Getting Hot in Here: Targeting Cancer Stem-like Cells with Hyperthermia.

J Stem Cell Transplant Biol 2017 29;2(2). Epub 2017 Dec 29.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE30, Cleveland, OH 44195, USA.

Cancer stem-like cells (CSCs) are a subset of cancer cells that are resistant to conventional radiotherapy and chemotherapy. As such, CSCs have been recognized as playing a large role in tumor initiation and recurrence. Although hyperthermia is broadly used in cancer treatment either alone or in combination with radio- or chemo-therapy, its potential to target CSCs is not well understood. Read More

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December 2017

Intensity-modulated radiotherapy and hypofractionated volumetric modulated arc therapy for elderly patients with breast cancer: comparison of acute and late toxicities.

Radiol Med 2018 Dec 13. Epub 2018 Dec 13.

Radiation Oncology, Cancer Care Center, Ospedale Sacro Cuore don Calabria, via Don Sempreboni 5, 37034, Negrar, Verona, Italy.

Purpose: To evaluate the differences between conventional fractionated intensity-modulated radiotherapy (IMRT) and hypofractionated (HypoRT) volumetric modulated arc therapy (VMAT) in elderly women affected by early-stage breast cancer (BC) in terms of RT-related acute/late side effect.

Materials And Methods: Between October 2011 and July 2015, 80 consecutive elderly BC patients were treated with IMRT for 5 weeks (40 patients) or HypoRT-VMAT for 3 weeks (40 patients). Inclusion criteria were: age ≥ 70 years, early BC (pT1-2 pN0-1), no prior neoadjuvant chemotherapy and non-metastatic disease. Read More

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December 2018

Cross-Sectional Study on MRI Restaging After Chemoradiotherapy and Interval to Surgery in Rectal Cancer: Influence on Short- and Long-Term Outcomes.

Ann Surg Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: The time interval between CRT and surgery in rectal cancer patients is still the subject of debate. The aim of this study was to first evaluate the nationwide use of restaging magnetic resonance imaging (MRI) and its impact on timing of surgery, and, second, to evaluate the impact of timing of surgery after chemoradiotherapy (CRT) on short- and long-term outcomes.

Methods: Patients were selected from a collaborative rectal cancer research project including 71 Dutch centres, and were subdivided into two groups according to time interval from the start of preoperative CRT to surgery (< 14 and ≥ 14 weeks). Read More

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December 2018

Low dosage of apatinib monotherapy as rescue treatment in advanced lung squamous cell carcinoma.

Cancer Chemother Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Respiratory and Critical Care, The First Affiliated Hospital of Soochow University, No.899, Pinghai Road, Suzhou, 215006, People's Republic of China.

Purpose: Platinum-based doublet chemotherapy and radiotherapy are the standard treatment option in advanced squamous cell carcinoma patients. However, few agents could be selected for subsequent post-second-line treatment. As a small molecule inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, apatinib had been proved in advanced gastric cancer. Read More

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December 2018
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Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers.

Front Oncol 2018 28;8:563. Epub 2018 Nov 28.

Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Head and neck cancer is the 6th most common malignancy worldwide and urgently requires novel therapy methods to change the situation of low 5-years survival rate and poor prognosis. Targeted therapy provides more precision, higher efficiency while lower adverse effects than traditional treatments like surgery, radiotherapy, and chemotherapy. Blockade of PD-1 pathway with antibodies against PD-1 or PD-L1 is such a typical targeted therapy which reconstitutes anti-tumor activity of T cell in treatments of cancers, especially those highly expressing PD-L1, including head and neck cancers. Read More

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November 2018

Proton vs. Photon Radiation Therapy for Primary Gliomas: An Analysis of the National Cancer Data Base.

Front Oncol 2018 28;8:440. Epub 2018 Nov 28.

Department of Therapeutic Radiology, Yale University, New Haven, CT, United States.

To investigate the impact of proton radiotherapy (PBT) on overall survival (OS) and evaluate PBT usage trends for patients with gliomas in the National Cancer Data Base (NCDB). Patients with a diagnosis of World Health Organization (WHO) Grade I-IV glioma treated with definitive radiation therapy (RT) between the years of 2004-13 were identified. Patients were stratified based on WHO Grade and photon radiotherapy (XRT) vs. Read More

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November 2018

Phase II Trial of Pure Hypofractionated Radiotherapy in the Treatment of Localized Carcinoma of the Prostate.

Cureus 2018 Oct 9;10(10):e3435. Epub 2018 Oct 9.

Radiation Oncology, Schulich School of Medicine & Dentistry - Western University, London, CAN.

Purpose To evaluate acute and late genitourinary (GU) and gastrointestinal (GI) toxicity and the biochemical control of pure hypofractionated radiotherapy (without acceleration) for the treatment of prostate cancer. Methods and materials This phase II prospective trial evaluated low-risk and intermediate-risk prostate cancer patients who received hypofractionated radiotherapy. Fifty-three patients with low-risk prostate cancer received 50 Gy in 15 fractions, 156 patients with intermediate-risk prostate cancer received 60 Gy in 20 fractions over eight weeks. Read More

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October 2018

Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells.

Oncoimmunology 2019 2;8(1):e1523097. Epub 2018 Nov 2.

Department of Radiation Oncology, University Hospital, Munich, Germany.

The major goal of radiotherapy is the induction of tumor cell death. Additionally, radiotherapy can function as cancer vaccination by exposing tumor antigens and providing adjuvants for anti-tumor immune priming. In this regard, the mode of tumor cell death and the repertoire of released damage-associated molecular patterns (DAMPs) are crucial. Read More

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November 2018

Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma.

Oncoimmunology 2019 11;8(1):e1507669. Epub 2018 Oct 11.

Department of Immunology, Lerner Research Institute, Cleveland, OH, USA.

Nearly half of melanoma patients develop brain metastases during the course of their disease. Despite advances in both localized radiation and systemic immunotherapy, brain metastases remain difficult to treat, with most patients surviving less than 5 months from the time of diagnosis. While both treatment regimens have individually shown considerable promise in treating metastatic melanoma, there is interest in combining these strategies to take advantage of potential synergy. Read More

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October 2018
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Weight loss as a prognostic factor for recurrence and survival in oropharyngeal squamous cell carcinoma patients.

Mol Clin Oncol 2018 Dec 5;9(6):666-672. Epub 2018 Oct 5.

Oncology Research Group, Santa Terezinha University Hospital, Joaçaba, SC 89600-000, Brazil.

Although the mortality rate of oropharyngeal squamous cell carcinoma (OPSCC) has been decreasing over the last 30 years, there has been a significant increase in the frequency of diagnosis of this type of cancer in several countries. Beyond the classic prognostic factors, such as TNM stage, there is a lack of predictive factors for recurrence and treatment response. A retrospective analysis of patients with OPSCC treated at the Oncology Department of the Santa Terezinha University Hospital between 2007 and 2012 was performed, with the aim of identifying new prognostic factors. Read More

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December 2018

Radiotherapy-associated intra-abdominal angiosarcoma after prostatic adenocarcinoma: Case reports.

Mol Clin Oncol 2018 Dec 5;9(6):592-596. Epub 2018 Oct 5.

Pathology Service, University Hospital of Saint Joan, Faculty of Medicine, IISPV, 'Rovira i Virgili' University, Reus, 43204 Tarragona, Spain.

Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. Read More

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December 2018
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CT scan and magnetic resonance diffusion-weighted imaging in the diagnosis and treatment of esophageal cancer.

Oncol Lett 2018 Dec 1;16(6):7117-7122. Epub 2018 Oct 1.

Department of Radiology, Jinan Children's Hospital, Jinan, Shandong 250022, P.R. China.

Value of computed tomography (CT) scan and diffusion-weighted imaging (DWI) in the diagnosis and treatment of esophageal cancer was investigated. Seventy-eight patients with esophageal cancer treated in Jinan Central Hospital (Jinan, China) from January 2013 to June 2014 were selected. All patients underwent CT scan and DWI examination, and their clinical history data were analyzed. Read More

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December 2018
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Prosthodontic rehabilitation of a sub-total maxillectomy defect with a definitive hollow obturator prosthesis using the modified lost-wax concept: A novel technique.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):225-228

Department of Prosthodontics, Christian Dental College, Ludhiana, Punjab, India.

Squamous cell carcinoma (SCC) of the oral cavity is relatively common in the Indian subcontinent with surgical resection and adjuvant radiotherapy/chemotherapy being the treatment modality of choice. Prosthetic rehabilitation with an obturator following resection is more economical and yields satisfactory results. Better patient acceptance and comfort necessitates hollowing the prosthesis to a great extent. Read More

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December 2018

Benefits of Elective Para-Aortic Radiotherapy for pN1 Prostate Cancer Using Arc Therapy (Intensity-Modulated or Volumetric Modulated Arc Therapy): Protocol for a Nonrandomized Phase II Trial.

JMIR Res Protoc 2018 Dec 13;7(12):e11256. Epub 2018 Dec 13.

Department of Radiation Oncology, University Hospitals Leuven, University of Leuven, Leuven, Belgium.

Background: In patients with prostate cancer (PCa) with histopathologically proven pelvic lymph node (LN) metastasis (pN1) after extended pelvic lymph node dissection (ePLND), multimodality treatment consisting of treatment of the primary tumor and whole pelvic radiotherapy (WPRT) combined with androgen deprivation therapy (ADT) offers promising results, leading to better cause-specific survival rates compared with ADT alone. However, in case more than one pelvic LN is invaded by the tumor, approximately 40% of the patients relapse biochemically and clinically. Clinical relapse is present in the para-aortic LNs (M1a disease) in up to 77% of the relapsing cases. Read More

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December 2018

Comprehensive Intra-Institution stepping validation of knowledge-based models for automatic plan optimization.

Phys Med 2018 Dec 10. Epub 2018 Dec 10.

Medical Physics, San Raffaele Scientific Institute, Milano, Italy.

Purpose: To develop and apply a stepping approach for the validation of Knowledge-based (KB) models for planning optimization: the method was applied to the case of concomitant irradiation of pelvic nodes and prostate + seminal-vesicles bed irradiation in post-prostatectomy patients.

Methods: The clinical VMAT plans of 52 patients optimized by two reference planners were selected to generate a KB-model (RapidPlan, v.13. Read More

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December 2018

Performance of Diffusion Kurtosis Imaging Versus Diffusion Tensor Imaging in Discriminating Between Benign Tissue, Low and High Gleason Grade Prostate Cancer.

Acad Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Physics, CNR ISC, UOS Roma Sapienza, Sapienza University of Rome, Rome, Italy.

Rationale And Objectives: To investigate the performance of diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) in discriminating benign tissue, low- and high-grade prostate adenocarcinoma (PCa).

Materials And Methods: Forty-eight patients with biopsy-proven PCa of different Gleason grade (GG), who provided written informed consent, were enrolled. All subjects underwent 3T DWI examinations by using b values 0, 500, 1000, 1500, 2000, and 2500 s/mm and six gradient directions. Read More

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December 2018

Influence of radiotherapy on immediate breast reconstruction after skin-sparing mastectomy. Before or after: Does it matter?

Cir Esp 2018 Dec 10. Epub 2018 Dec 10.

Profesor titular, Universidad de Zaragoza, jefe Unidad de Mama, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Introduction: The use of bilateral mastectomy with immediate reconstruction is increasing. Radiotherapy increases complications; however, its uses have been extended. We evaluate the profile of the complications and long-term failure of reconstruction through a comparative analysis with a cohort without radiotherapy. Read More

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December 2018

PET/CT Lung Ventilation and Perfusion Scanning using Galligas and Gallium-68-MAA.

Semin Nucl Med 2019 Jan 17;49(1):71-81. Epub 2018 Nov 17.

Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne Australia; Sir Peter MacCallum Department of Oncology, the University of Melbourne, Melbourne, Australia. Electronic address:

Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (Tc) with Gallium-68 (Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with Ga-carbon nanoparticles using the same synthesis device as Technegas. Perfusion imaging can be performed with Ga-macroaggregated albumin. Read More

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January 2019
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