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Oper Neurosurg (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.

Intramedullary tumors of the spinal cord are rare and account for 2% to 8.5% of all central nervous system tumors. In adults, ependymomas are the most common intramedullary tumors. Read More

J Travel Med 2018 Dec 12. Epub 2018 Dec 12.

Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto; SAR Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Canada.

Mol Pharm 2018 Dec 12. Epub 2018 Dec 12.

Immunoglobulin gamma (IgG) monoclonal antibodies (mAbs) are glycoproteins that have emerged as powerful and promising protein therapeutics. During the process of production, storage and transportation, exposure to ambient light is inevitable, which can cause protein physical and chemical degradation. For mechanistic studies of photo-degradation, we have exposed IgG4-Fc to UV light. Read More

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):297-300

Hospital Guillermo Kaelin de la Fuente. Lima, Perú; Universidad San Ignacio de Loyola, Lima, Perú.

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. We present the case of a 57-year-old female patient who started with hematemesis and progressive episodes of melena, weight loss and epigastralgia. It is derived from the National Institute of Neoplastic Diseases where gastroscopy and biopsy are performed. Read More

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):253-260

Departamento de Cirugía Oncológica Abdominal, Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.

The study objective was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer who underwent radical gastrectomy D2.

Materials And Methods: We reviewed retrospectively 498 medical records of patients with gastric cancer who were attended at the National Institute of Neoplastic Diseases (INEN) between 2008 and 2011and met the inclusion and exclusion criteria. They were distributed into 4 groups according to their LNR, LNR0: 0, LNR1: 0-0. Read More

Inorg Chem 2018 Dec 12. Epub 2018 Dec 12.

School of Chemical Sciences , Dublin City University , Dublin 9 , Ireland.

[Ru(TAP)(dppz)] (TAP = 1,4,5,8-tetraazaphenanthrene; dppz = dipyrido[3,2- a:2',3'- c]phenazine) is known to photo-oxidize guanine in DNA. Whether this oxidation proceeds by direct photoelectron transfer or by proton-coupled electron transfer is still unknown. To help distinguish between these mechanisms, spectro-electrochemical experiments have been carried out with [Ru(TAP)(dppz)] in acetonitrile. Read More

Biomacromolecules 2018 Dec 12. Epub 2018 Dec 12.

Institut Galien Paris-Sud, UMR CNRS 8612, Univ Paris-Sud, Univ. Paris-Saclay, Faculté de Pharmacie , 5 rue Jean-Baptiste Clément , F-92296 Châtenay-Malabry cedex , France.

2-Methylene-1,3-dioxepane (MDO) and different vinyl ether (VE) monomers were successfully copolymerized by free-radical radical ring-opening copolymerization (rROP) to yield P(MDO- co-VE) copolymers with M = 7 000-13 000 g·mol and high molar fractions of MDO ( F = 0.7-0.9). Read More

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Titanium dioxide nanomaterials have good capability to prevent human cells from damage under UV irradiation. However, some studies indicated that the nanoscale of titanium dioxide could potentially cause harmful effects such as free radicals generation under UV irradiation and thereby accelerate the progress of cell aging. Fullerenes can scavenge large amounts of free radicals due to the fact that fullerenes contain enormous amount of π electrons with low lying lowest unoccupied molecular orbital (LUMO), but its adverse properties, such as the poor solubility in water, restricted the applicability. Read More

Phys Chem Chem Phys 2018 Dec 12. Epub 2018 Dec 12.

Paul Scherrer Institute, CH-5232 Villigen-PSI, Switzerland.

Excited xylyl (methyl-benzyl) radical isomers have been studied by femtosecond time-resolved photoelectron spectroscopy and mass spectrometry. Depending on the substitution we find different deactivation channels after excitation into the D3(2A'') state (310 nm, 4 eV). While the ortho and para isomer exhibit deactivation rates similar to the benzyl radical, meta-xylyl sticks out and depletes twice as fast into the vibrationally hot ground state. Read More

AJR Am J Roentgenol 2018 Dec 12:1-6. Epub 2018 Dec 12.

1 Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637.

Objective: The objective of our study was to investigate the comparative effectiveness of different MRI sequences for the estimation of index lesion volume in patients with prostate cancer (PCa) compared with ground truth volume measured on whole-mount pathology.

Materials And Methods: Patients with PCa underwent multiparametric MRI (mpMRI) on a 3-T MRI scanner before radical prostatectomy. Forty PCa index lesions were identified and outlined on histology by a pathologist. Read More

ACS Chem Biol 2018 Dec 12. Epub 2018 Dec 12.

SAM-dependent methyltransferases are intensely studied since they play important roles in the methylation of biomolecules in all domains of life. In this study we describe that the methyltransferase VioH from Cysotobacter violaceus catalyzes a so far unknown cyclization of SAM to azetidine-2-carboxylic acid (AZE), which is proposed to be the precursor of the unusual 4-methylazetidinecarboxylic acid (MAZ) moiety of vioprolides. In vitro biochemical investigations reveal that SAM is converted to AZE in the presence of VioH, while MAZ is generated by coexpression of VioH and the radical SAM enzyme VioG in Myxococcus xanthus or by combination of VioH and the cell lysate of M. Read More

Rev Bras Enferm 2018 ;71(suppl 6):2848-2853

Universidade Federal Fluminense, Aurora Nursing School of Affonso Costa. Niterói, Rio de Janeiro, Brazil.

Objective: To reflect on the sensitive behaviors of indigenous healthcare professionals based on the philosophy of Emmanuel Lévinas, to ratify completeness, equity, and humanity.

Method: reflective study.

Reflection: Studies have identified inadequacies in meeting the indigenous singularities. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1241-S1243

Department of Urology, Faculty of Medicine, Kemerburgaz University, Medical Park Bursa Hospital, Bursa, Turkey.

Paratesticular rhabdomyosarcoma (RMS) is a rare nongerm cell intrascrotal malignant tumor in children and young adult/teens resulting from the mesenchymal tissues of the tunica vaginalis, epididymis, spermatic cord, and testis. RMS accounts for approximately 7% of all genitourinary tract RMSs and 12% of all pediatric scrotal neoplasms. Patients usually present with a painless unilateral scrotal mass. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1220-S1222

Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.

Neurilemmomas are rare tumors of neural crest cell origin that occur most commonly in the head and neck region. Intercostal neurilemmomas are extremely rare and are mostly seen as solitary tumors in the posterior mediastinum. Only one case report of multiple intercostal neurilemmomas has been documented previously. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1183-S1187

Department of Gland Vascular Surgery, Affiliated Hospital of Yan'an University, Yan'an, ShaanXi, China.

Aims: Breast cancer is a great public health problem. It remains unclear how pharmorubicin induces cardiac dysfunction in patients with breast cancer. Our study was aimed to explore the influence of pharmorubicin on the left ventricular ejection fraction (EF) of patients with breast cancer and its potential mechanism. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1152-S1157

Department of Chemistry, Key Laboratoryof Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

Objective: This study aims to observe the changes and diagnostic values of urinary trace elements in patients with renal cell carcinoma (RCC).

Methods: A total of 28 RCC patients that had been performed radical surgery for more than 3 years were included into this case-control study; meanwhile, thirty healthy volunteers without kidney diseases were set as the control group over the same period. The levels of various urinary trace elements in both groups were measured, and the results were performed the significance analysis and pattern recognition analysis using with partial least square discriminant analysis and Fisher analysis. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1070-S1075

Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Ionizing radiation is a critical threat to biomolecules, especially DNA. Various combinatorial compounds have been studied to protect this biomolecule. Melatonin has been reported as a direct and indirect free radical scavenger, but in this study, we explored the effect of melatonin on assisting in DNA repair by expression of Cdkn1a and Rad50; both of these genes are involved in DNA repair signaling, induced by radiation in rat peripheral blood. Read More

Recent Pat Drug Deliv Formul 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmaceutics, ITS College of Pharmacy, NH-34, Ghaziabad-201206. India.

Aim And Background: The rationale of this study is that, treatment of asthmatic Guinea pig with combined administration of Montelukast sodium and green tea extract (GTE) as a single capsule will mitigate the inflammatory injury in the airways and weaken the asthmatic response. Recent patents for the treatment of asthma researched a polyphenolic alternatives for antiasthmatic combination therapy, especially for those patients who remains unresponsive or poorly responsive for current asthma therapy (US7232585B2). Synergistic activity of green tea polyphenols and therapeutic, prophylatic agents are also reported in some recent patents (US20120172423A1, US20150320696A1). Read More

J Phys Chem Lett 2018 Dec 12. Epub 2018 Dec 12.

In traditional fluorescent organic light-emitting diodes (OLEDs), the upper limit of internal quantum efficiency (IQE) is only 25% because 75 % triplet excitons created on the fluorescent dyes are non-luminous. Here, luminescent radicals are proposed as the sensitizer. Under ideal conditions, electrons and holes firstly recombine on the sensitizer molecule to create doublet excitons, then through energy transfer to generate singlet excitons on the fluorescent dye, finally via radiative decay to emit light. Read More

Cell Mol Neurobiol 2018 Dec 11. Epub 2018 Dec 11.

School of Biotechnology, National Institute of Technology Calicut, Calicut, 673601, India.

The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesis served as a premise to experimentally uncover the functional role of miR-9 in post-ischemic neuronal survival and regeneration. The oxygen-glucose deprivation (OGD) in SH-SY5Y cells significantly reduced miR-9 expression, while miR-9 mimic transfection enhanced post-ischemic neuronal cell viability. Read More

J Mater Sci Mater Med 2018 Dec 11;29(12):191. Epub 2018 Dec 11.

Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

The aim of the study was to synthesize and evaluate chitosan-based topical cross-linked hydrogel membranes of mupirocin for new pharmaceutical controlled release application. These cross-linked structured membranes were synthesized by modification of free radical polymerization. Low molecular weight (LMW) chitosan is cross-linked with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with a crosslinker N,N-methylenebisacrylamide (MBA). Read More

Res Rep Urol 2018 22;10:233-235. Epub 2018 Nov 22.

Department of Urology, Stanford University School of Medicine, Stanford, CA, USA,

Utilization of pre-biopsy multiparametric MRI (mpMRI) is increasing. To optimize the usefulness of mpMRI, physicians should accurately quote patients a numerical risk of cancer based on their MRI. The Prostate Imaging Reporting and Data System (PIRADS) standardizes interpretation of mpMRI; however, reported rates of clinically significant prostate cancer (CSC) stratified by PIRADS score vary widely. Read More

Ital J Food Saf 2018 Sep 27;7(3):7342. Epub 2018 Sep 27.

Dipartimento di Medicina Veterinaria, Università degli Studi di Perugia.

Considering that many plant-derived substances show antioxidant and antimicrobial properties, natural antioxidant administered through feed in livestock animals could increase the shelf life of meat and meat products. The aim of this work was to study the effect of olive oil by-products on chicken meat lipid and protein oxidation and oxidative stability during storage. Two hundred and ninety-seven 22-day-old fast growing (Ross 308) female chicks were randomly assigned to three experimental grower-finisher diets: i) a basal control diet (CTR), ii) CTR diet supplemented with a low dosage (4. Read More

Ital J Food Saf 2018 Sep 26;7(3):6846. Epub 2018 Sep 26.

Institute of Tropical Aquaculture.

An aqueous extraction of moringa () leaves were prepared as the edible coats for keeping the quality of the giant freshwater prawn (). In addition, the antioxidant properties and activity; total phenolic content (TPC), total flavonoid contents (TFC), free radical scavenging activity (DPPH), and ferric reducing antioxidant power (FRAP) of moringa leaves were also determined. The phenolic compounds and antioxidant properties in the moringa leaves are low; 16. Read More

Evid Based Complement Alternat Med 2018 14;2018:8617070. Epub 2018 Nov 14.

College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

In this study, optimization of enzyme-assisted extraction, purification, characterization, and its bioactivities of polysaccharides from (HCP) was investigated. It was found that the optimum extraction conditions were 3% of enzyme concentration ( ), 30 of liquid-to-solid ratio ( ), 56°C of extraction temperature ( ), 200W of ultrasonic power ( ), 10 min of extraction time ), and 5 of pH value ( ). Under optimum conditions, the experimental yield (4. Read More

Front Psychol 2018 27;9:2279. Epub 2018 Nov 27.

Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.

Breast cancer is the most common cancer in women worldwide, with increases in diagnoses at all ages. Due to several age-related factors, older breast cancer patients show particular difficulties in adjusting to breast cancer and its related treatments. One consistent indicator of vulnerability to long-term complications is emotional distress occurring within 3 months of diagnosis. Read More

Cancer Manag Res 2018 21;10:6071-6078. Epub 2018 Nov 21.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China,

Background: Salivary duct carcinoma (SDC) is an extremely rare and highly malignant carcinoma, and surgical radical resection is the most effective therapy. However, there were quite a proportion of patients receiving non-radical resections, and how to treat them remained controversial. Thus, the aim of this study is to evaluate whether postoperative radiotherapy could be a salvage treatment of SDC in major salivary glands without radical operations. Read More

Indian J Surg Oncol 2018 Dec 16;9(4):644-646. Epub 2018 May 16.

Department of Surgical Oncology, Bombay Hospital, Bombay Hospital Marg, Marine Drive, Mumbai, 400020 India.

Sarcomatoid carcinoma is an extremely rare aggressive tumor variant comprising about 0.3% of all primary tumors of the urinary bladder and carries an overall dismal prognosis. Diagnosis is important and is sometimes difficult. Read More

Indian J Surg Oncol 2018 Dec 22;9(4):558-564. Epub 2018 Sep 22.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh India.

To study the current trends of renal cell carcinoma (RCC) in terms of demographic characteristics, clinical presentation, staging, mode of management, histopathology, and survival characteristics from a high volume tertiary care teaching institute in North India. We retrospectively reviewed the records of all patients of RCC between January 2006 and December 2015 and variables like age, gender, symptoms, tumor size/location/number, stage, type of surgery, histopathology, and survival characteristics were studied. One hundred forty-four patients were included in the study. Read More

Nat Rev Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.

J Biol Chem 2018 Dec 11. Epub 2018 Dec 11.

Chemistry, Pennsylvania State University, United States.

The lipoyl cofactor plays an integral role in several essential biological processes. The last step in its biosynthetic pathway, the attachment of two sulfur atoms at C6 and C8 of an -octanoyl-lysyl chain, is catalyzed by lipoyl synthase (LipA), a member of the radical SAM superfamily. In addition to the [4Fe-4S] cluster common to all radical SAM enzymes, LipA contains a second [4Fe-4S] auxiliary cluster, which is sacrificed during catalysis to supply the requisite sulfur atoms, rendering the protein inactive for further turnovers. Read More

Lipids Health Dis 2018 Dec 11;17(1):280. Epub 2018 Dec 11.

University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020, Tyczyn, Poland.

Background: Extracts from plants, rich in antioxidants may be used as active ingredients of many preparations, mainly due to their antioxidant, regenerative and anti-aging properties. The work involved a comprehensive evaluation of the Jerusalem artichoke (Helianthus tuberosus L.) leaf and tuber extract as a multifunctional raw material. Read More

Nutr Neurosci 2018 Dec 12:1-14. Epub 2018 Dec 12.

a Department of Psychiatry , School of Medicine, Trinity College Dublin , Dublin , Ireland.

Objective: Mitochondrial dysfunction has been implicated in the pathophysiology of schizophrenia and other neuropsychiatric disorders. Though the exact mechanisms and clinical implications for this dysfunction are not fully determined, there is a hypothesis that deficiency in coenzyme Q10 (CoQ10) may contribute to mitochondrial impairments and be reflected in cognitive, affective, and energy disturbances in the disorders. CoQ10 is a critical component of the mitochondrial respiratory chain and an essential free radical scavenger, necessary for mitochondrial function. Read More

Hum Exp Toxicol 2018 Dec 12:960327118818236. Epub 2018 Dec 12.

1 Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Water contamination with metals due to anthropogenic activity is increasing and subsequent exposure increases the risk of associated toxicity. Exposure is not limited to a single metal but usually involves mixtures of different metals at different concentrations. Little is known about the contribution of this type of exposure, in humans, to the development of non-communicable diseases such as cardiovascular disease, and an increased risk to thrombosis. Read More

J Am Chem Soc 2018 Dec 11. Epub 2018 Dec 11.

Performing electron-transfer reactions on metal nanoparticles requires separation of charge carriers at the nanoparticle and their transfer to the reacting molecules. Inducing these reactions using light is challenging due to the exceedingly short lifetimes of energetic charge carriers formed in metal nanoparticles under light illumination. The results described here show that certain conditions must be met to drive these electron-transfer reactions on plasmonic nanoparticles. Read More

J Cardiol Cases 2014 Dec 2;10(6):221-225. Epub 2014 Sep 2.

Department of Cardiology, Osaka Medical College, Osaka, Japan.

A 48-year-old woman was referred to the cardiology department due to a large mobile mass in the right ventricle. The patient had undergone radical hysterectomy and bilateral salpingo-oophorectomy for a uterine squamous cell carcinoma approximately 3.5 years before. Read More

J Cardiol Cases 2011 Oct 19;4(2):e115-e120. Epub 2011 Aug 19.

Second Department of Internal Medicine, Kansai Medical University, Moriguchi City, Japan.

A 79-year-old female had paroxysmal supraventricular tachycardia. However, she was implanted with an inferior vena cava filter and her descending aorta had significant meandering. It was thought that the insertion of the catheters would be difficult from the femoral vessels. Read More

J Cardiol Cases 2011 Jun 12;3(3):e143-e148. Epub 2011 Apr 12.

Second Department of Internal Medicine, Kansai Medical University, Moriguchi City, Japan.

An 84-year-old male had experienced palpitations. He was transported to our hospital for treatment of palpitations. A 12-lead electrocardiogram (ECG) showed regular tachycardia with a wide QRS complex of 153 bpm, and the P wave was not clear. Read More

Dalton Trans 2018 Dec 7. Epub 2018 Dec 7.

Sch Phys Sci & Technol, Jiangsu Key Lab NSLSCS, Nanjing Normal Univ, Nanjing 210023, Jiangsu, P. R. China.

The combination of LnIII ions (GdIII, TbIII or DyIII) and a pyrazole nitronyl nitroxide radical results in three isomorphous complexes, namely, [Ln(hfac)3(NIT-Pyz)]2 (Ln = Gd(1), Tb(2), Dy(3); hfac = hexafluoroacetylacetone; NIT-Pyz = 2-{3-pyrazolyl}-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide). Single crystal X-ray diffraction studies revealed that all of them are composed of two crystallographically independent mononuclear systems, in which the central LnIII ions are coordinated by three hfac and one bidentate chelating NIT-Pyz radical. The central LnIII ions are all in square antiprism geometry (D4d) polyhedron configurations. Read More

Cell Physiol Biochem 2018 7;51(5):2250-2261. Epub 2018 Dec 7.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background/aims: Diabetes is associated with increased incidence of myocardial dysfunction, which is partly characterized by interstitial and perivascular fibrosis. Cardiac fibroblasts have been identified as an important participant in the development of cardiac fibrosis. Exposure of cultured cardiac fibroblasts to high glucose resulted in increased collagen synthesis. Read More

J Plant Physiol 2018 Nov 8;232:248-256. Epub 2018 Nov 8.

Plant Physiology and Biochemistry Laboratory, Department of Botany, Visva-Bharati University, Santiniketan, 731235, West Bengal, India. Electronic address:

Post-germination plant growth depends on the regulation of reactive oxygen species (ROS) metabolism, spatiotemporal pH changes and Ca homeostasis, whose potential integration has been studied during Vigna radiata (L.) Wilczek root growth. The dissipation of proton (H) gradients across plasma membrane (PM) by CCCP (protonophore) and the inhibition of PM H-ATPase by sodium orthovanadate repressed SOD (superoxide dismutase; EC 1. Read More

Chemosphere 2018 Dec 4;219:100-108. Epub 2018 Dec 4.

School of Civil Engineering, Southeast University, Nanjing, 210096, China; Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education, Southeast University, Nanjing, 210096, China.

A high-efficient, eco-friendly and applicable oxidant of percarbonate (SPC, NaCO·1.5HO) is applied as oxidant in ozonation (O) process. In this work, coumarin (COU) decomposition by O and O/SPC was proposed in terms of diverse parameters, including ozone concentration, SPC dosage and pH, with regard to the pseudo-first-order kinetic model. Read More

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, 5309 CCC 5940, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA. Electronic address:

5% of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort.117 UTUC resections with UUT biopsy and/or cytology specimens from 2000-2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

Hepatol Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Background & Aim: Primary liver carcinoma with sarcomatous change is a rare malignancy associated with high aggressiveness and poor prognosis. However, the characteristics of these types of tumors are still unknown. The aim of this study was to assess the imaging features, prognostic significance, and clinicopathological characteristics of patients with these tumors. Read More

Prostate 2018 Dec 9. Epub 2018 Dec 9.

Urological Research Centre, Department of Urology, Vejle Hospital, Vejle, Denmark.

Background: Overtreatment is a well-known clinical challenge in local prostate cancer (PCa). Although risk assessment models have contributed to a better stratification of patients with local PCa, a tailored management is still in its infancy. Over the last few decades, microRNAs (miRNAs) have shown promising results as biomarkers in PCa. Read More

Chemistry 2018 Dec 11. Epub 2018 Dec 11.

CHINA.

Oxidation of β-to-β directly linked and sulfur-bridged meso-amino NiII-porphyrin dimers with PbO2 gave helical tetrapyrrin (biliverdin analogue)-fused NiII-porphyrins. These ring cleaving reactions differ markedly from the previously reported oxidation of a β-β linked NiII-porphyrin dimer carrying one amino-group that gave an azepine-fused porphyrin dimer. The tetrapyrrin-fused NiII-porphyrins display intense NIR absorption bands reaching at 1200-1400 nm and reversible redox processes because of the highly π-conjugated networks and rigid structures. Read More

J Food Sci 2018 Dec;83(12):2970-2975

Dept. of Biological Sciences and Health, Federal Univ. of Amapa, Rod. Juscelino Kubitschek, Km-02 - Jardim Marco Zero, Macapá-AP, 68903-419, Brazil.

Ellagic acid (EA) has demonstrated several biological properties, such as antioxidant, antimicrobial, and enzymatic inhibition. Zein and chitosan (CHI) are natural polymers whose biological potential has also gained attention. Therefore, this paper aimed to evaluate the antimicrobial, antioxidant, anticollagenase, and antielastase properties of EA, zein, and chitosan isolated or in combination. Read More

Chemistry 2018 Dec 7. Epub 2018 Dec 7.

University of Manchester, School of Chemistry, Oxford Rd, M13 9PL, Manchester, UNITED KINGDOM.

A light-mediated Truce-Smiles arylative rearrangement is described that proceeds in the absence of any photocatalyst. The protocol creates two C-C bonds from simple starting materials, with the installation of an aryl ring and a difluoroacetate moiety across unactivated alkenes. The reaction likely proceeds via a radical mechanism, utilizing a light mediated reduction of ethyl bromodifluoroacetate by N,N,N',N'-tetramethylethylenediamine (TMEDA) to set up intermolecular addition to an unactivated alkene, followed by the Truce-Smiles rearrangement. Read More

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

University at Albany, SUNY, Chemistry, 1400 Washington Ave, 12222, Albany, UNITED STATES.

The development of visible-light-mediated allylation of unactivated sp3 C-H bonds is reported. The remote allylation was directed by the amidyl radical, which was generated by photocatalytic fragmentation of a pre-functionalized amide precursor. Both aromatic and aliphatic amide derivatives could successfully deliver the remote C-H allylation products in good yields. Read More

BJU Int 2018 Dec 10. Epub 2018 Dec 10.

School of Physics, The University of Sydney, Sydney, New South Wales, Australia.

Objectives: To develop a registration framework for correlating positron emission tomography/computed tomography (PET/CT) images with multiparametric MRI (mpMRI) and histology of the prostate, thereby enabling voxel-wise analysis of imaging parameters.

Patients And Methods: In this prospective proof-of-concept study, nine patients scheduled for radical prostatectomy underwent mpMRI and PET/CT imaging prior to surgery. One had PET imaging using F-fluoromethylcholine (FCH), five using Ga-labelled prostate-specific membrane antigen (PSMA)-HBED-CC (PMSA-11) and three using a trial Ga-labelled THP-PSMA tracer. Read More