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Eur J Med Chem 2018 Nov 28;163:207-214. Epub 2018 Nov 28.

Department of Neurosurgery, Kurume University, School of Medicine, Fukuoka, Japan. Electronic address:

Ischemia-reperfusion injuries produce reactive oxygen species that promote the peroxide lipid oxidation process resulting in the production of an endogenic lipid peroxide, 4-hydroxy-trans-2-nonenal (4-HNE), a highly cytotoxic aldehyde that induces cell death. We synthesized a novel 4-HNE scavenger - a carnosine-hydrazide derivative, l-carnosine hydrazide (CNN) - and examined its neuroprotective effect in a model of transient ischemia. PC-12 cells were pre-incubated with various doses (0-50 mmol/L) of CNN for 30 min, followed by incubation with 4-HNE (250 μM). Read More

Accid Anal Prev 2018 Dec 3;123:176-189. Epub 2018 Dec 3.

Department of Mathematics and Statistics, University of Wyoming, 1000 E University Ave, Laramie, WY 82071, USA. Electronic address:

Interstate 80 in Wyoming is one of the busiest freight corridors that is characterized with harsh winter conditions and challenging mountainous roadway sections. The fatality rates in Wyoming are always typically higher than the national level. The 402-mile I-80 corridor in Wyoming was selected by the USDOT FHWA for piloting connected vehicle technology to improve the safety and mobility of heavy trucks. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Beijing Advanced Innovation Centre for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, China; Institute of Microbiology, Beijing Forestry University, Beijing 100083, China.

To contribute towards effective exploitation and utilization of natural antioxidants, response surface methodology (RSM) was employed to optimize the medium composition for the production of exopolysaccharides from the medicinal mushroom Ganoderma lingzhi (GLEPS). An optimal medium for GLEPS production was gave through Plackett-Burman design, path of steepest ascent, and Box-Behnken design as follows: glucose (59.62 g/L), yeast extract (10. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.

The present article reports the development of chitosan (CS) based hydrogel series by varying the concentration of cross-linking agent i.e. N,N'-methylenebisacrylamide (MBA) (0. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of life sciences, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Thiol Protease inhibitors (cystatins) are endogenous natural inhibitors of cysteine proteases. They are present in all mammalians cells and body fluids. Cystatin are allocated into three major families. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad 826004, India. Electronic address:

Herein, a novel binary graft copolymeric flocculant [St-g-(PAAm-co-PMETAC)] has been developed using starch, polyacrylamide (PAAm) and poly (2-methacryloyloxy ethyl trimethyl ammonium chloride) (PMETAC). The copolymer has been synthesised by grafting of PAAm and PMETAC chains on starch backbone using free radical polymerization. FTIR and H NMR spectral analyses have been used for structural confirmation of developed copolymer. Read More

J Org Chem 2018 Dec 6. Epub 2018 Dec 6.

Oxidative C-C coupling of carbazoles possessing various substituents are demonstrated, in presence of organic (metal-free) recyclable oxidants, such as, DDQ or CA/H+ for accessing bicarbazole regioisomers. Differently substituted carbazoles are examined to showcase regioselectivity discrimination (3,3'- versus 1,3'-bicarbazoles), and preferences based on sterics and electronics in oxidative coupling. Finally, a mechanism that involves carbazole radical cation has been traced (evidenced) and proposed based on the UV-vis-NIR absorption and EPR spectroscopy results. Read More

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: The aim of this study was to examine the long-term results of implants in orbital reconstruction after exenteration.

Materials And Methods: From 1998 to 2012, patients undergoing implant-supported rehabilitation after subtotal or total exenteration due to a tumor were included in a retrospective study. All the patients were evaluated for soft tissue reconstruction, irradiation, complications, abutments, hygiene index, implant mobility, and long-term success. Read More

Environ Technol 2018 Dec 6:1-23. Epub 2018 Dec 6.

b Univ Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR - UMR6226 , F-35000 rennes , France.

Heterogeneous electro-Fenton mineralization of Acid Red 18 (AR18) in aqueous solution was studied with magnetite FeO (MNPs) and hematite FeO (HNPs) nanoparticles as catalysts. High mineralization yields of AR18 were obtained with magnetite, 81% TOC removal after 180  min of electrolysis in 40 mg.L FeO pH 3. Read More

J Am Chem Soc 2018 Dec 6. Epub 2018 Dec 6.

Ribosomally-synthesized and post-translationally-modified peptides (RiPPs) are an emerging class of natural products that harbor diverse chemical functionalities, usually introduced via the action of a small number of tailoring enzymes. We have been interested in RiPP biosynthetic gene clusters that encode unusual metalloenzymes, as these may install yet unknown alterations. Using a new bioinformatic search strategy, we recently identified an array of unexplored RiPP gene clusters that are quorum sensing-regulated and contain one or more uncharacterized radical S-adenosylmethionine (RaS) metalloenzymes. Read More

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Neuro-Urology, CTO - Spinal Unit, Città della Salute e della Scienza di Torino, Turin, Italy.

Purpose: The aim of our study is to evaluate the efficacy and safety of ATOMS® system for the treatment of postoperative male stress urinary incontinence (SUI).

Materials And Methods: We retrospectively evaluated all patients treated at our institution for postoperative male SUI with ATOMS® implant. We excluded patients with low bladder compliance (< 20 mL / cmH2O), uncontrolled detrusor overactivity, detrusor underactivity (BCI < 100), urethral or bladder neck stricture and low cystometric capacity (< 200 mL). Read More

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

Departamento de Anatomia Patológica da Universidade Estadual de Campinas - UNICAMP, Campinas, SP, Brasil.

Introduction: In view of the detailed histologic evaluation of prostate cancer (PC), it is usually advisable to provide a "second opinion" to confirm diagnosis. This study aimed to compare the Gleason score (GS) of initial diagnosis versus that of histopathologic review of patients with PC. The secondary objective was to compare initial GS versus histopathologic review versus post - surgical histopathology. Read More

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

American Hospital, Istanbul, Turkey.

Introduction: The success of the robot assisted radical prostatectomy (RARP) procedures depend on a successful team, however the literature focuses on the performance of a console surgeon. The aim of this study was to evaluate surgical outcomes of the surgeons during the learning curve in relation to the bedside assistant's experience level during RARP.

Materials And Methods: We retrospectively reviewed two non - laparoscopic, beginner robotic surgeon's cases, and we divided the patients into two groups. Read More

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Urology, University of Pittsburgh, Pennsylvania, U.S.A.

Purpose: To describe the clinical characteristics, treatment patterns, and outcomes in patients with small cell bladder cancer at our institution, including those who received prophylactic cranial irradiation (PCI) for the prevention of intracranial recurrence.

Materials And Methods: Patients with small cell bladder cancer treated at a single institution between January 1990 and August 2015 were identified and analyzed retrospectively for demographics, tumor stage, treatment, and overall survival.

Results: Of 44 patients diagnosed with small cell bladder cancer, 11 (25%) had metastatic disease at the time of presentation. Read More

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):424-428. Epub 2018 Nov 30.

Instituto de Seguridad Social del Estado de México y Municipios, Centro Médico ISSEMyM Ecatepec, Servicio de Cirugía General. Ecatepec, Estado de México, México

Background: Male breast cancer is a rare entity, with an approximate rate of 1.1 / 100 000 in the US, with an average age of 67 years. In all cases a genetic study must be performed, in order to find mutations in known genes, and after the resolution of the disease, based on the results, a contralateral prophylactic mastectomy should be considered. Read More

Chem Asian J 2018 Dec 6. Epub 2018 Dec 6.

Qingdao University, College of Chemistry and Chemical Engiineering, 308 Ningxia Road, 266071, Qingdao, CHINA.

Through regulating the pH values, a series of iodo-argentate/cuprate hybrids, [Me3(4-TPT)]4[Ag6I18] (1, Me3(4-TPT) = N,N',N''-trimethyl-2,4,6-tris(4-pyridyl)-1,3,5-triazine), [Me3(4-TPT)][M5I8] (M=Ag/2, Cu/2a), [Me3(3-TPT)][M5I8] (Me3(3-TPT) = N,N',N''-trimethyl-2,4,6-tris(3-pyridyl)-1,3,5-triazine, M=Ag/3, Cu/4), exhibit adjustable structural variations with different dimensional structures, have been obtained under solvothermal conditions. They are directed by two types of in situ N-alkylation TPT-derivatives (Me3(4-TPT) for 1/2/2a and Me3(3-TPT) for 3/4) and represent the isolated units (1), 1-D polymeric chain (4), 2-D layered structures (2/2a, 3) based on diverse metal iodide clusters. These compounds possess reducing band gaps comparing with the bulk β-AgI and CuI and belong to potential semiconductor materials. Read More

Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.

ETH Zürich, Department of Biology, Vladimir-Prelog-Weg 4, 8093, Zürich, SWITZERLAND.

Post-translational modifying enzymes from the S-adenosyl-L-methionine (AdoMet) radical superfamily garner attention due to their ability to accomplish challenging biochemical reactions. Among them, a family of AdoMet radical epimerases catalyze irreversible L- to D-amino acid transformations of diverse residues, including 18 sites in the complex sponge-derived polytheonamide toxins. These enzymes are from the proteusin family of ribosomally synthesized and post-translationally modified peptide natural products and act on precursor proteins with relatively large N-terminal leaders and highly variable core sequences. Read More

Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemistry, Fudan University, Shanghai 200433, China.

The radical S-adenosylmethionine (SAM) superfamily is currently the largest known enzyme family. These enzymes reductively cleave SAM to produce a highly reactive 5'-deoxyadenosyl (dAdo) radical, which abstracts a hydrogen from the substrate and initiates diverse reactions. The canonic dAdo radical-mediated hydrogen abstraction can be changed to radical addition reactions by using olefin-containing substrate analogues, which result in adenosylation reactions. Read More

J Neurotrauma 2018 Dec 6. Epub 2018 Dec 6.

University of Pittsburgh, Neurosurgery , 3434 Fifth Ave , Pittsburgh, Pennsylvania, United States , PA ;

New neuroprotective therapies for severe traumatic brain injury (TBI) have not translated from pre-clinical to clinical success. Numerous explanations have been suggested in both the pre-clinical and clinical arenas. Coverage of TBI in the lay press has reinvigorated interest creating a golden age of TBI research with innovative strategies to circumvent roadblocks. Read More

J Phys Chem A 2018 Dec 6. Epub 2018 Dec 6.

The photofragmentation dynamics of 1,1,1,2-tetrafluoroethane (R134a) with photon energies from 12 eV up to 320 eV, surrounding the C 1s edge is discussed. The ionic moieties were measured according to their mass to charge ratio, in coincidence with the photoelectrons (PEPICO mode), and collected as a function of the incident photon energy. In the C K core region, the fragmentation patterns are examined in terms of site specific excitation of the CH2FCF3 molecule. Read More

Ir Med J 2018 08 13;111(7):790. Epub 2018 Aug 13.

Department of Urology, Cork University Hospital, Wilton, Cork, Ireland

Aims Accurate preoperative knowledge of tumour stage is important in preoperative planning at radical prostatectomy (RP). The aim of this study was to assess the predictive ability of multiparametric MRI for detecting pathological outcomes. Methods A retrospective review was performed of all patients who underwent RP over a 4 year period. Read More

Med Chem 2018 Dec 5. Epub 2018 Dec 5.

Faculty of Agrobiotehnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, Osijek. Croatia.

Background: Rhodanine is known for its potential and important role in the medicinal chemistry since its derivatives exhibit a wide range of pharmacological activities such as antibacterial, antifungal, antidiabetic, antitubercular, anti-HIV, antiparasitic, antioxidant, anticancer, anti-proliferative and anthelmintic agents.

Objectives: Since N-substituted rhodanine synthons are rarely commercially available, it is desirable to develop a straight forward synthetic approach for the synthesis of these key building blocks. The objective was to synthesize a series of rhodanine derivatives and to investigate their antimicrobial and antioxidant activity. Read More

Org Lett 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemistry , University of Science and Technology of China , Hefei , Anhui 230026 , China.

The first example of phenanthroline- BuOK promoted intramolecular radical C-H arylation of N-(2-iodobenzyl)indoles without involvement of transition metals has been developed. A variety of substituted 6 H-isoindolo [2, 1-a] indoles were prepared by a simple and efficient intramolecular cyclization using 1,10-phenanthroline in the presence of potassium tert-butoxide and chlorobenzene. This strategy provides a fast and versatile access to isoindolo[2,1- a]indole derivatives for the synthesis of pharmaceuticals and organic electroluminescent (EL) materials. Read More

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

By using a multidisciplinary and multi-technique approach, we have addressed the issue of attaching a molecular quantum bit to a real surface. First, we demonstrate that an organic derivative of the pyrene-Blatter radical is a potential molecular quantum bit. Our study of the interface of the pyrene-Blatter radical with a copper-based surface reveals that the spin of the interface layer is not cancelled by the interaction with the surface and that the Blatter-radical is resistant in presence of molecular water. Read More

Environ Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax, University of Sfax, Sfax, Tunisia.

The risk of pesticides on the human health and environment has drawn increasing attention. Today, new tools are developed to reduce pesticide adverse effects. This study aimed to evaluate the toxicity induced by, thiamethoxam (TMX), and the cytoprotective effect of a novel polysaccharide, named fenugreek seed water polysaccharide (FWEP) in vitro using H9c2 cardiomyoblastes and in vivo using Wistar rat model. Read More

Chemistry 2018 Dec 5. Epub 2018 Dec 5.

Friedrich-Alexander-Universitat Erlangen-Nurnberg, Chemistry and Pharmacy, Schuhstrasse 19, 91052, Erlangen, GERMANY.

Radical carbofluorination reactions starting from arylhydrazines and non-activated alkenes, in which the C-F bond is formed through the use of Selectfluor, can be improved through the addition of anisole. Since direct trapping products could be detected only in trace amounts, anisole does primarily act as a reversible scavenger for the highly reactive ammonium radical dication released from Selectfluor in the C-F bond forming step. As shown for three diverse substitution patterns, the main role of anisole is to prevent, or at least reduce, the undesired addition of the ammonium radical dication to the alkene, which in turn leads to an unfavorable consumption of the arylhydrazine-derived precursors required for carbofluorination. Read More

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Objectives: The present study aimed to investigate the clinical prognostic significance of radiomics signature (R-signature) in patients with gastric cancer who had undergone radical resection.

Methods: A total of 181 patients with gastric cancer who had undergone radical resection were enrolled in this retrospective study. The association between the R-signature and overall survival (OS) was assessed in the primary cohort and verified in the validation cohort. Read More

Environ Sci Pollut Res Int 2018 Dec 5. Epub 2018 Dec 5.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P., 202002, India.

In the present study, oxido-reductive degradation of diazo dye, Direct Red 23, has been carried out by Ziziphus mauritiana peroxidases (specific activity 17.6 U mg). Peroxidases have been immobilized via simple adsorption and cross-linking by glutaraldehyde; adsorbed and cross-linked enzyme retained 94. Read More

Langenbecks Arch Surg 2018 Dec 5. Epub 2018 Dec 5.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090, Vienna, Austria.

Purpose: Total parathyroidectomy (tPTX) in patients with renal hyperparathyroidism (RHPT) aims at the complete removal of all hyperfunctioning parathyroid tissue. Whenever parathyroidectomy is termed "total," undetectable postoperative parathyroid hormone (PTH) levels within the first postoperative week are expected. The aim of this study was to evaluate if tPTX is technically possible using a radical surgical procedure. Read More

Chem Cent J 2018 Dec 5;12(1):131. Epub 2018 Dec 5.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, People's Republic of China.

Banana as a typical climacteric fruit soften rapidly, resulting in a very short shelf life after harvest. Sodium dichloroisocyanurate (NaDCC) is reported to be an effectively antibacterial compound. Here, we investigated the effects of NaDCC on ripening and senescence of harvested banana fruit at physiological and molecular levels. Read More

Neurosurg Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

Surgical resections of meningiomas, the most common intracranial tumor in adults, can only be curative if radical resection is achieved. Potentially, the extent of resection could be improved, especially in complex and/or high-grade meningiomas by fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA), indocyanine green (ICG), or fluorescein. This review aims to summarize and evaluate these fluorescence-guided meningioma surgery techniques. Read More

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.

Objectives: To compare perioperative and short-term postoperative complication rates between patients receiving radical cystectomy (RC) after neoadjuvant chemotherapy (NAC) and patients undergoing RC alone. Secondary objectives were to compare overall survival (OS) and cancer-specific survival (CSS).

Materials And Methods: Clinico-pathological data of all patients who received RC between 1996 and 2015 were retrospectively collected. Read More

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.

Purpose: To evaluate the prognostic value of positive surgical margins (PSM) focality for the prediction of biochemical recurrence (BCR) in patients undergoing robotic-assisted radical prostatectomy (RARP) for prostate cancer.

Methods: All men with clinically localized prostate cancer undergoing RARP in our tertiary referral centre between May 2005 and August 2016 were retrospectively identified. Patients with neoadjuvant therapy were excluded. Read More

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

USC Institute of Urology, Keck Medicine of USC, University of Southern California, Los Angeles, CA, USA.

Objectives: To determine and investigate the intraoperative factors that contribute to a change in plan from continent orthotopic neobladder to ileal conduit or continent cutaneous diversion at the time of radical cystectomy.

Subjects And Methods: A retrospective review of our prospectively maintained bladder cancer database was performed. Of the 711 patients who underwent radical cystectomy from 2012 to 2016, 387 (54. Read More

Heliyon 2018 Nov 22;4(11):e00936. Epub 2018 Nov 22.

King Abdullah University of Science and Technology (KAUST), BESE Division, The BioActives Lab, Thuwal, 23955-6900, Saudi Arabia.

Strigolactones (SLs), a novel class of plant hormones, are key regulator of plant architecture and mediator of biotic interactions in the rhizosphere. Root-released SLs initiate the establishment of arbuscular mycorrhizal (AM) symbiosis by inducing spore germination and hyphal branching in AM fungi (AMF). However, these compounds also trigger the germination of root parasitic weeds, paving the way for deleterious infestation. Read More

PeerJ 2018 28;6:e5991. Epub 2018 Nov 28.

PostGraduate Program in Ethnobiology and Nature Conservation, Universidade Regional do Cariri, Crato, Ceará, Brazil.

Background: Fruit consumption is currently considered beyond the nutritional aspects because of the important roles in disease prevention and benefits to health. The objective of this study was to characterize the chemical profile and evaluate the antioxidant and antimicrobial properties of different fractions obtained from fruit pulps of (MFFs).

Methods: Initially, chloroform, ethyl acetate and ethanol fractions were obtained from the pulps. Read More

J Cancer 2018 21;9(23):4346-4354. Epub 2018 Oct 21.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center.

Appropriate cycle number of perioperative chemotherapy for patients with locoregionally advanced rectal cancer (LARC) remains unknown. This study aimed to evaluate how cycle number of perioperative chemotherapy influenced the prognosis of LARC patients. In this study, a total of 388 consecutive patients were enrolled and retrospectively reviewed if they were diagnosed with untreated stage cII-III LARC and treated with neoadjuvant chemoradiotherapy plus radical surgery followed by adjuvant chemotherapy or not. Read More

J Cancer 2018 20;9(22):4204-4214. Epub 2018 Oct 20.

Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

As an adjuvant immunotherapy, cytokine-induced killer cells (CIKs) infusion has been demonstrated to exert potent effectiveness in several types of cancer patients who received curative treatment. However, controversy exists regarding whether nasopharyngeal carcinoma (NPC) patients can benefit from additional treatment after radical radiotherapy or chemoradiotherapy to improve their distant control and survival. In this retrospective study, we aimed to evaluate the efficacy of adjuvant CIK cells therapy in NPC patients with stage II-IVB after curative treatment. Read More

Oncogene 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.

Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies due to dose limiting toxicities and obesity-related complications, highlighting the need to develop novel therapeutic approaches for treating obese patients. We recently found that obesity leads to an increase in tumor-infiltrating macrophages with activated NLRC4 inflammasome and increased interleukin (IL)-1β production. Read More

Proc Natl Acad Sci U S A 2018 Dec 5. Epub 2018 Dec 5.

Department of Earth System Science, Stanford University, Stanford, CA 94305;

Archaea have many unique physiological features of which the lipid composition of their cellular membranes is the most striking. Archaeal ether-linked isoprenoidal membranes can occur as bilayers or monolayers, possess diverse polar head groups, and a multiplicity of ring structures in the isoprenoidal cores. These lipid structures are proposed to provide protection from the extreme temperature, pH, salinity, and nutrient-starved conditions that many archaea inhabit. Read More

Biosci Rep 2018 Dec 5. Epub 2018 Dec 5.

School of Pharmacy and Biomolecular Sciences, The University of Brighton, Huxley Building, Lewes Road, Brighton, BN2 4GJ, United Kingdom

NAD(P)H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction of quinones and a wide range of other organic compounds. Its physiological role is believed to be partly the reduction of free radical load in cells and the detoxification of xenobiotics.  It also has non-enzymatic functions stabilising a number of cellular regulators including p53. Read More

Injury 2018 Nov 22. Epub 2018 Nov 22.

Orthopaedics and Trauma Unit, Emergency Department, Ospedale Policlinico San Martino, Largo R. Benzi 10-16132, Genoa, Italy.

Septic nonunion is one of the most serious complications after an open fracture because both the infection and the bone defect need to be dealt with. Treatment is always protracted and expensive, and the result is uncertain. In the 1980s, Masquelet first described the technique of the induced membrane and autologous bone grafting to manage critical bone defects. Read More

Nat Prod Res 2018 Dec 5:1-8. Epub 2018 Dec 5.

a Central Marine Fisheries Research Institute , Cochin , India.

Phytochemical investigation on the biologically active compounds of seaweed Gracilaria salicornia {(C. Agardh) E.Y. Read More

Nat Prod Res 2018 Dec 5:1-4. Epub 2018 Dec 5.

a Unité de recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques. Université frères Mentouri , Constantine , Algérie.

Convolvulus trabutianus Schweinf. & Muschl. is an endemic plant from northern Sahara used in folk medicine. Read More

Radiat Oncol J 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology and Imaging, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile. Read More

Rev Prat 2016 Nov;67(9):1019-1022

CHU La Pitié-Salpêtrière, Paris, France.

An example of clinical controversy related to EBM. The DCCT study for type 1 diabetes (1993) and UKPDS for type 2 (1998) had demonstrated the benefit of the hypoglycemic treatment with, for 1 point of HbA1c less, 30% less microangiopathy events. The cardiovascular benefit was less obvious, as these studies were performed in patients with primary prevention. Read More

An Acad Bras Cienc 2014 Jun;86(2):923-934

Departamento de Engenharia de Alimentos, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brasil.

This study focused on maximizing the extraction of total phenolics and flavonoids as well as the antioxidant activity measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay from roasted yerba mate (Ilex paraguariensis) as a function of time (5, 7.5 and 10 min) and temperature of extraction (60, 75 and 90°C). The data were subjected to Response Surface Methodology and the results showed that polynomial equations were significant, did not present lack of fit, and presented adjusted determination coefficients above 98%, proving their suitability for prediction purposes. Read More

Int J Urol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Objective: To report the outcomes of laparoscopic radical nephrectomy with inferior vena cava thrombectomy for right renal cell carcinoma at Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Method: A retrospective review of the clinical records of five patients who underwent laparoscopic radical nephrectomy with inferior vena cava thrombectomy for right renal cell carcinoma between 2013 and 2017 was carried out. The surgical procedure included ligation and cutting of the right renal artery, followed by kidney mobilization. Read More

Free Radic Biol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Pharmaceutical Science, University of Perugia, Perugia, Italy. Electronic address:

Lipid peroxidation is one of the earliest pathogenic events of non-alcoholic fatty liver disease (NAFLD). In this context, an increased oxidation of the lipoperoxyl radical scavenger α-tocopherol (α-TOH) should occur already in the subclinical phases of the disease to compensate for the increase oxidation of the lipid excess of liver and possibly of other tissues. However, this assumption remains unsupported by direct analytical evidence. Read More

Int J Biol Macromol 2018 Nov 30. Epub 2018 Nov 30.

Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

In this work, a novel impedimetric biosensor has been fabricated for detection of DNA damage induced by doxorubicin (DX). Cytochrome P450 reductase (CPR) is required for electron transfer from nicotinamide adenine dinucleotide phosphate (NADPH) to cytochrome P450 (CP450) which causes DX to undergo a one-electron reduction of the p-quinone residue to form the semiquinone radical resulting in the generation of free hydroxyl radical which causes DNA damage. After modification of bare glassy carbon electrode (GCE) with multiwalled carbon nanotubes (MWCNTs) and chitosan (Ch), CPR and CP450 were co-immobilized onto the surface of Ch/MWCNTs/GCE by cross-linking CPR, CP450 and Ch through addition of glutaraldehyde. Read More