5,376 results match your criteria Radical Hysterectomy


Obturator nerve injury in a chemo and radio-resistant patient with a locally-advanced cervical cancer after two previous uterine artery embolizations for severe vaginal bleeding: Case report and review of literature.

Eur J Obstet Gynecol Reprod Biol 2020 Jul 2;252:355-358. Epub 2020 Jul 2.

Department of Obstetrics and Gynecology, Presidio Policlinico di Monserrato, University of Cagliari, Monserrato, Italy.

Chemo and radiotherapy are actually the gold standard of treatment for locally-advanced cervical cancer. We report a case report showing a repaired (video 1) right obturator nerve after an incidental injury during a right internal iliac artery closure with 10 mm titanium clip for severe pelvic bleeding in a patient with locally-advanced cervical cancer. A 52 year-old postmenopausal woman with a chemo and radio-resistant locally-advanced squamous cervical cancer was admitted at our department for severe vaginal bleeding after two previous uterine artery embolizations. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.07.002DOI Listing

Typical variant of takotsubo cardiomyopathy in oncological patients. Two case reports and review of the literature.

Folia Med Cracov 2020 ;60(1):45-54

Department of Coronary Artery Disease and Heart Failure, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.

Takotsubo cardiomyopathy (TCM) represents an acute systolic left ventricular dysfunction typically triggered by severe psychological or physical stress. Oncological patients due to emotional distress of the diagnosis, proinflammatory and prothrombotic nature of cancer and also physical stress often following complex anticancer therapies are at high-risk of TCM. Moreover, there are also few reports of TCM associated with oncological treatment, mostly chemotherapy. Read More

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January 2020

Antibiotic prophylaxis for gynecologic cancer surgery.

Taiwan J Obstet Gynecol 2020 Jul;59(4):514-519

Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, College of Medicine, South Korea; Paik Institute for Clinical Research, Inje University, College of Medicine, South Korea. Electronic address:

Objectives: The use of prophylactic antibiotics in elective gynecologic cancer surgery is essential. We aimed to establish the optimal duration of antibiotic administration to reduce the overuse of antibiotics in gynecologic cancer surgery.

Materials And Methods: We conducted a retrospective study based on the descriptive and statistical analysis of the clinical records of patients who underwent a radical hysterectomy or staging operation for gynecologic cancer between January 2014 and October 2015 at Busan Paik Hospital. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.008DOI Listing

Laparoscopic versus open radical hysterectomy in women with early stage cervical cancer: A systematic review and meta-analysis.

Taiwan J Obstet Gynecol 2020 Jul;59(4):481-488

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan; Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan. Electronic address:

This review aimed to evaluate the short term and long-term outcomes of laparoscopic radical hysterectomy (LRH) versus abdominal radical hysterectomy (ARH) for early-stage cervical cancer. A search of PubMed, Medline and Scopus databased from 2000 to 2018 was conducted. Thirty studies were retrieved including 22 retrospective cohort studies and 8 prospective cohort studies. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.003DOI Listing

[Impact of hysterectomy on urinary incontinence: A systematic review].

Prog Urol 2020 Jul 7. Epub 2020 Jul 7.

Service de gynécologie, CHU de Nantes, 38, boulevard Jean-Monnet, 44000 Nantes, France; CIC, centre d'investigations clinique, CHU de Nantes, 5, allée de l'Ile-Gloriette, 44093 Nantes cedex 01, France; Centre fédératif de pelvi-périnéologie, France. Electronic address:

Introduction: The impact of a hysterectomy on urinary incontinence is a controversial subject in the literature.

Objective: To evaluate the prevalence and incidence of urinary incontinence after a hysterectomy as well as associated risk factors such as the type of hysterectomy, the surgical approach, urodynamic criteria and uterine disease.

Study Design: We conducted a systematic review in Pubmed database with the following keywords and MeSH term: hysterectomy, urinary incontinence. Read More

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http://dx.doi.org/10.1016/j.purol.2020.06.002DOI Listing

A Concise Paradigm on Radical Hysterectomy: The Comprehensive Anatomy of Parametrium, Paracolpium and the Pelvic Autonomic Nerve System and Its Surgical Implication.

Cancers (Basel) 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Surgery, Institut Bergonié, 33076 Bordeaux, France.

The current understanding of radical hysterectomy is more centered on the uterus and little is discussed regarding the resection of the vaginal cuff and the paracolpium as an essential part of this procedure. The anatomic dissections of two fresh and 17 formalin-fixed female pelvis cadavers were utilized to understand and decipher the anatomy of the pelvic autonomic nerve system (PANS) and its connections to the surrounding anatomical structures, especially the paracolpium. The study mandates the recognition of the three-dimensional (3D) anatomic template of the parametrium and paracolpium and provides herewith an enhanced scope during a nerve-sparing radical hysterectomy procedure by precise description of the paracolpium and its close anatomical relationships to the components of the PANS. Read More

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http://dx.doi.org/10.3390/cancers12071839DOI Listing

Adherence to postoperative thromboprophylactic medication among gynecologic oncology patients: A subanalysis.

Gynecol Oncol 2020 Jul 5. Epub 2020 Jul 5.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine Anschutz Medical Campus, Aurora, CO, USA.

Introduction: Venous thromboembolism (VTE) is a major cause of morbidity and mortality among gynecologic cancer patients, especially in the immediate postoperative period. We sought to identify patterns related with patient non-adherence to postoperative prophylactic anticoagulation.

Methods: Participant data (N = 400) were reviewed from a previously conducted randomized controlled trial comparing the safety and efficacy of prophylactic postoperative anticoagulation with enoxaparin versus apixaban among gynecologic oncology patients. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.06.505DOI Listing

Nomogram Predicting the Likelihood of Parametrial Involvement in Early-Stage Cervical Cancer: Avoiding Unjustified Radical Hysterectomies.

J Clin Med 2020 Jul 5;9(7). Epub 2020 Jul 5.

Faculty of Medicine, Paris University, 75006 Paris, France.

Background: We aimed to establish a tool predicting parametrial involvement (PI) in patients with early-stage cervical cancer and select a sub-group of patients who would most benefit from a less radical surgery.

Methods: We retrospectively reviewed patients from two prospective multicentric databases-SENTICOL I and II-from 2005 to 2012. Patients with early-stage cervical cancer (FIGO 2018 IA with lympho-vascular involvement to IIA1), undergoing radical surgery (hysterectomy or trachelectomy) with bilateral sentinel lymph node (SLN) mapping with no metastatic node or PI on pre-operative imaging, were included. Read More

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http://dx.doi.org/10.3390/jcm9072121DOI Listing

Effect of the surgical approach on survival outcomes in patients undergoing radical hysterectomy for cervical cancer: A real-world multicenter study of a large Chinese cohort from 2006 to 2017.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Objective: To compare survival outcomes of minimally invasive surgery (MIS) and laparotomy in early-stage cervical cancer (CC) patients.

Methods: A multicenter retrospective cohort study was conducted with International Federation of Gynecology and Obstetrics (FIGO, 2009) stage IA1 (lymphovascular invasion)-IIA1 CC patients undergoing MIS or laparotomy at four tertiary hospitals from 2006 to 2017. Propensity score matching and weighting and multivariate Cox regression analyses were performed. Read More

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http://dx.doi.org/10.1002/cam4.3287DOI Listing

Minimizing Fertility-sparing Treatment for Low Volume Early Stage Cervical Cancer; Is Less the (R)Evolution?

Anticancer Res 2020 Jul;40(7):3651-3658

Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, U.K.

Background/aim: The aim of this study was to conduct a review on less radical fertility-sparing surgical treatment for early-stage cervical cancer.

Materials And Methods: We conducted a Medline search from 2014 to 2018 regarding less radical fertility-sparing techniques, such as simple trachelectomy or cervical conization, with pelvic lymphadenectomy. We also assessed the impact of the removal of the parametrium on the obstetric and oncologic outcome, in women who desire to preserve their fertility. Read More

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http://dx.doi.org/10.21873/anticanres.14354DOI Listing

Considerations for performing microwave endometrial ablation (MEA) - Three cases with abnormal test results of endometrial tissue discovered by chance when performing MEA.

Int J Hyperthermia 2020 ;37(1):749-752

Department of Obstetrics and Gynecology, International University of Health and Welfare Hospital, Nasushiobara-City, Japan.

Microwave endometrial ablation (MEA) is beginning to be used widely in Japan as a minimally invasive alternative to conventional total hysterectomy for functional hypermenorrhea, uterine fibroids, hypermenorrhea due to organic diseases such as uterine adenomyosis, and acute heavy uterine bleeding. MEA was introduced in our hospital in January 2016. It is performed after a screening via cytodiagnosis and histodiagnosis to ensure that there are no malignant diseases in the uterus. Read More

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http://dx.doi.org/10.1080/02656736.2020.1781267DOI Listing
January 2020

Uterus transplantation: joys and frustrations of becoming a 'complete' woman-a qualitative study regarding self-image in the 5-year period after transplantation.

Hum Reprod 2020 Jul 3. Epub 2020 Jul 3.

Department of Obstetrics & Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Study Question: How is a women's self-image affected by uterus transplantation (UTx)?

Summary Answer: Women experienced receiving a uterus in both positive and negative ways, but in general, their self-image was positively affected; regardless of whether they have given birth to a child or not, recipients describe themselves as being 'back to normal' after the hysterectomy to remove the transplanted uterus.

What Is Known Already: UTx has repeatedly proved to be a successful treatment for absolute uterine factor infertility. However, there has been no previous qualitative long-term research into the self-image of women undergoing UTx. Read More

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http://dx.doi.org/10.1093/humrep/deaa143DOI Listing

Perioperative Complications and Safety Evaluation of Robot-Assisted Radical Hysterectomy of Cervical Cancer After Neoadjuvant Chemotherapy.

Cancer Manag Res 2020 12;12:4483-4492. Epub 2020 Jun 12.

Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, People's Republic of China.

Purpose: To evaluate the perioperative complications of patients with cervical cancer who are treated with robot-assisted radical hysterectomy (RRH) and to further evaluate the safety of patients undergoing NACT.

Methods: A total of 805 consecutive cervical cancer patients undergoing RRH were involved in this report. Their clinical characteristics were retrieved from hospital medical records. Read More

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http://dx.doi.org/10.2147/CMAR.S243986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305848PMC

Hysterectomy for Recurrent/Residual Cervical Cancer Following Definitive Radiotherapy.

In Vivo 2020 Jul-Aug;34(4):2173-2177

Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Background/aim: Radical hysterectomy has been used for local recurrent or persistent (LR) cervical cancer after radiotherapy (RT), but the rate of serious complications is high and tolerance is low. This study determined the efficacy, safety, and prognostic factors of adjuvant simple hysterectomy in LR cervical cancer post-RT.

Patients And Methods: A total of 21 patients who underwent hysterectomy for LR cervical cancer post-RT in our Department between May 2007 and September 2018 were included in the study. Read More

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http://dx.doi.org/10.21873/invivo.12026DOI Listing

Radical Hysterectomy for Cervical Cancer in Patients With Uterine Prolapse.

In Vivo 2020 Jul-Aug;34(4):2073-2078

Department of Surgery, "Ponderas" Academic Hospital, Bucharest, Romania.

Background/aim: Association between cervical cancer and uterine prolapse represents a scarce eventuality. This is a case series of 11 patients diagnosed with different stages of cervical cancer in association with uterine prolapse.

Patients And Methods: Between 2014 and 2020, 11 patients were diagnosed with cervical cancer on prolapsed uterine cervix. Read More

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http://dx.doi.org/10.21873/invivo.12010DOI Listing

A practical method of using the anatomical space of the vesicouterine ligament for laparoscopic radical hysterectomy: a retrospective cohort study.

J Int Med Res 2020 Jun;48(6):300060520926857

Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: To investigate the practicality of a new method using anatomical spaces for performing standard laparoscopic radical hysterectomy (LRH) without ureteral injury in patients with cervical cancer.

Methods: Clinicopathological characteristics and perioperative complications were retrospectively analysed in 440 patients with stages IB1 to IIB cervical cancer. The patients were assigned to two of the following groups: LRH by our method of using anatomical landmarks (anatomical space group, n = 217) and the traditional method (traditional group, n = 223). Read More

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http://dx.doi.org/10.1177/0300060520926857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328497PMC

Efficacy and toxicity of postoperative external beam radiotherapy or chemoradiation for early-stage cervical cancer.

Int J Gynecol Cancer 2020 Jun 25. Epub 2020 Jun 25.

Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Objective: The aim of this study was to assess the impact of the evolving role of the addition of chemotherapy to postoperative radiotherapy on oncological outcomes and toxicity in patients with early-stage cervical cancer after radical hysterectomy.

Methods: Retrospective cohort study of patients with stage IB1-IIB FIGO 2009 cervical cancer treated from November 1999 to May 2015 by primary surgery and radiotherapy (46-50.4 Gy in 1. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001131DOI Listing

Prognostic factors influencing pelvic, extra-pelvic, and intraperitoneal recurrences in lymph node-negative early-stage cervical cancer patients following radical hysterectomy.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 16;252:94-99. Epub 2020 Jun 16.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Republic of Korea.

Objective: The aim of this study was to evaluate the clinicopathologic factors influencing pelvic, extra-pelvic, and intraperitonal recurrences and survival in patients with lymph node-negative early-stage cervical cancer treated with abdominal/laparoscopic/robotic radical hysterectomy (ARH/LRH/RRH).

Study Design: We retrospectively reviewed clinicopathologic data of 342 patients with FIGO stage IB-IIA cervical cancer (2018 FIGO staging) treated with RH and retroperitonal lymphadenectomy between February 2000 and November 2018. Several clinicopathologic factors such as surgical methods including LRH/RRH-vaginal colpotomy (VC) and LRH/RRH-intracorporeal colpotomy (IC), surgical resection margin, and parametrial/endomyometrial infiltration were selected. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.030DOI Listing
June 2020
1.627 Impact Factor

Case report of large malignant pericardial effusion in a post-surgical setting of endometrial mixed carcinoma: A description of unique cytological, histological, and immunohistochemical findings.

SAGE Open Med Case Rep 2020 10;8:2050313X20930919. Epub 2020 Jun 10.

Department of Pathology, Kanazawa Medical University Hospital, Ishikawa, Japan.

Appearance of endometrial carcinoma in pericardial effusion is extremely rare. Its major etiological factors include lung cancer, breast cancer, lymphoma, and leukemia. We herein report a case of a large malignant pericardial effusion 7 years after surgery for endometrial carcinoma. Read More

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http://dx.doi.org/10.1177/2050313X20930919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290248PMC

Comparison of laparoscopic versus open radical hysterectomy in patients with early-stage cervical cancer: a multicenter study in China.

Int J Gynecol Cancer 2020 Jun 22. Epub 2020 Jun 22.

Department of Gynecology and Obsterics, West China Second University Hospital, Sichuan University, Chengdu, China

Introduction: Recently, the safety of minimally invasive surgery in the treatment of cervical cancer has been questioned. This study was designed to compare the disease-free survival and overall survival of abdominal radical hysterectomy and laparoscopic radical hysterectomy in patients with early-stage cervical cancer.

Methods: A total of 1065 patients with early-stage cervical cancer who had undergone abdominal/laparoscopic radical hysterectomy between January 2013 and December 2016 in seven hospitals were retrospectively analyzed. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001340DOI Listing

Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy.

Med Sci Monit 2020 Jun 22;26:e922028. Epub 2020 Jun 22.

Department of Anesthesiology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine (TCM), Shanghai, China (mainland).

BACKGROUND This study investigated the effects of various doses of S-ketamine on depression and pain management of cervical carcinoma patients with mild/moderate depression. MATERIAL AND METHODS This randomized, double-blind, controlled study included 417 cervical carcinoma patients who received laparoscopic modified radical hysterectomy from April 2015 to July 2018 and who also had mild/moderate depression symptoms based on HAMD-17 scores (8~24). All patients were randomized into 4 groups: 1) the control group, 2) the racemic ketamine group, 3) the high-dose S-ketamine group; and 4) the low-dose S-ketamine group. Read More

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http://dx.doi.org/10.12659/MSM.922028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331479PMC

Prognostic value of lymphovascular space invasion in early-stage cervical cancer.

Int J Gynecol Cancer 2020 Jun 21. Epub 2020 Jun 21.

Gynecologic Surgery, CHU Toulouse, Toulouse, Midi-Pyrénées, France.

Objective: Few prognostic factors likely to influence therapeutic management of early-stage cervical cancer are currently recognized. The objective of this study was to determine the prognostic value of lymphovascular space invasion (LVSI) in overall survival of patients with early-stage cervical cancer.

Methods: This is a retrospective study of patients treated for early-stage cervical cancer between January 1996 and December 2013 at Toulouse University Hospital and the Cancer Center Claudius Regaud Institute. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001274DOI Listing

Analysis of the surgical management of patients with recurrent cervical cancer after radiotherapy and chemotherapy.

Rev Col Bras Cir 2020 15;47:e20202443. Epub 2020 Jun 15.

Universidade de Cruz Alta, Cruz Alta, Biomedicina - Cruz Alta - RS - Brasil.

Objective: To analyze the results of morbidity and survival after curative and palliative surgery in recurrent cervical cancer patients who underwent chemoradiation as their primary treatment. Another goal was to assess the factors associated with curative and non-curative procedures.

Methods: This was a retrospective cohort consisting of patients undergoing surgery curative and palliative from January 2011 to December 2017 at a high complexity oncology center. Read More

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http://dx.doi.org/10.1590/0100-6991e-20202443DOI Listing

Minimally Invasive Surgery Is Feasible in Patients with Liver and Kidney Transplantation.

Ann Transplant 2020 Jun 16;25:e922602. Epub 2020 Jun 16.

Department of Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.

BACKGROUND Minimally invasive surgery (MIS) has rapidly advanced, but its use in transplant patients has lagged. We share our experience of MIS for patients after kidney and liver transplantation and compare our results with similar studies in the literature. MATERIAL AND METHODS This study included 14 MIS (12 laparoscopic, 2 transvaginal) procedures for 13 transplant cases (6 liver and 7 kidney) done from May 2006 to May 2018. Read More

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http://dx.doi.org/10.12659/AOT.922602DOI Listing

Protective Maneuver to Avoid Tumor Spillage during Laparoscopic Radical Hysterectomy: Vaginal Cuff Closure.

J Minim Invasive Gynecol 2020 Jun 12. Epub 2020 Jun 12.

Department of Gynecologic Oncology, University Hospital La Fe, Valencia, Spain (all authors).

Objective: To demonstrate the feasibility of a protective maneuver to avoid tumor exposure during laparoscopic radical hysterectomy.

Design: This video illustrates the vaginal cuff closure technique in cervical cancer surgery.

Setting: The Oncologic Gynecology Department at the University Hospital La Fe. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.06.007DOI Listing

Back to the Future: Schauta-Amreich Radical Vaginal Hysterectomy Assisted by Laparoscopy with Sentinel Lymph Node Biopsy for Early-stage Cervical Cancer.

J Minim Invasive Gynecol 2020 Jun 10. Epub 2020 Jun 10.

Department of Gynaecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Sorbonne University, (all authors); UMRS 938, Centre de recherche Saint Antoine, Sorbonne Université (Drs. Ferrier, Touboul, Boudy, Owen, Bendifallah, and Daraï), Paris, France.

The popularity of laparoscopy to perform radical hysterectomy has massively increased over the last 2 decades. However, oncologic outcomes (overall and disease-free survival) have been found to be better in patients managed by laparotomy compared with laparoscopy, challenging this surgical route. Compared with laparotomy, vaginal access reduces postoperative morbidity, while avoiding potential cancer spread associated with laparoscopy. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.06.004DOI Listing

Invasive cervical adenocarcinoma arising from extension of recurrent vulval Paget's disease.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Gynaecological Oncology, King Edward Memorial Hospital for Women, Perth, Western Australia, Australia.

An 83-year-old woman with a long-standing history of both invasive and vulval extramammary Paget's disease (EMPD) was referred to a tertiary gynaecological oncology service for suspicion of contiguous extension to the vagina and cervix. Vaginal biopsies confirmed EMPD; however, a loop excision of the cervix demonstrated invasive adenocarcinoma arising from Paget's disease. The patient subsequently underwent laparoscopic radical hysterectomy, bilateral salpingo-oophorectomy and radical upper vaginectomy, confirming FIGO stage 1B1 cervical adenocarcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2019-232424DOI Listing

Long-term outcomes of intensity-modulated radiation therapy (IMRT) and high dose rate brachytherapy as adjuvant therapy after radical hysterectomy for cervical cancer.

Int J Gynecol Cancer 2020 Jun 11. Epub 2020 Jun 11.

Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA

Objective: Compared with 3D-planned pelvic radiation, intensity-modulated radiation therapy (IMRT) has been shown to reduce acute toxicity in cervical cancer patients after radical hysterectomy. This study evaluated late toxicity and patterns of failure after post-operative pelvic IMRT interdigitated weekly with high dose rate brachytherapy.

Methods: This retrospective study included 53 cervical cancer patients treated between January 2006 and August 2019 with radical hysterectomy, lymphadenectomy, and post-operative IMRT and high dose rate brachytherapy. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001412DOI Listing

Survival After Minimally Invasive vs Open Radical Hysterectomy for Early-Stage Cervical Cancer: A Systematic Review and Meta-analysis.

JAMA Oncol 2020 Jun 11. Epub 2020 Jun 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.

Importance: Minimally invasive techniques are increasingly common in cancer surgery. A recent randomized clinical trial has brought into question the safety of minimally invasive radical hysterectomy for cervical cancer.

Objective: To quantify the risk of recurrence and death associated with minimally invasive vs open radical hysterectomy for early-stage cervical cancer reported in observational studies optimized to control for confounding. Read More

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http://dx.doi.org/10.1001/jamaoncol.2020.1694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290695PMC

Tailored radical hysterectomy for locally advanced cervical cancer.

Int J Gynecol Cancer 2020 Jun 9. Epub 2020 Jun 9.

Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Objective: The survival and prognostic factors for locally advanced cervical cancer treated with nerve-sparing Okabayashi-Kobayashi radical hysterectomy have not been elucidated. We aimed to evaluate the oncological outcomes of those patients after radical hysterectomy with adjuvant chemotherapy.

Methods: This retrospective cohort study was conducted from January 2002 to December 2011. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001387DOI Listing

Neoadjuvant chemotherapy followed by radical surgery versus concurrent chemoradiotherapy in patients with FIGO stage IIB cervical cancer: the CSEM 006 study.

Int J Gynecol Cancer 2020 Jun 9. Epub 2020 Jun 9.

Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

Background: Concurrent chemoradiotherapy is the first-line treatment for FIGO stage IIB cervical cancer. Neoadjuvant chemotherapy followed by radical surgery may provide another treatment option.

Primary Objective: To compare the therapeutic outcomes of neoadjuvant chemotherapy followed by surgery with cisplatin-based concurrent chemoradiotherapy for stage IIB cervical cancer. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001357DOI Listing

Efficacy of laparoscopic nerve-sparing radical hysterectomy in the treatment of early cervical cancer.

J BUON 2020 Mar-Apr;25(2):743-749

Department of Obstetrics and Gynaecology, Shanxian Central Hospital, Heze, China.

Purpose: To evaluate the efficacy and safety of laparoscopic nerve-sparing radical hysterectomy (LNSRH) in the treatment of early cervical cancer.

Methods: The clinical data of 152 patients with early cervical cancer undergoing radical hysterectomy (RH) were retrospectively analyzed, and the patients were divided into LNSRH group (n=76) and laparoscopic RH (LRH) group (n=76) according to the surgical approaches. The tumor recurrence and survival were recorded during postoperative follow-up, and the disease-free survival (DFS) and overall survival (OS) were compared between the two groups of patients. Read More

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June 2020
0.706 Impact Factor

Primary conization overcomes the risk of developing local recurrence following laparoscopic radical hysterectomy in early stage cervical cancer.

Int J Gynaecol Obstet 2020 Jun 8. Epub 2020 Jun 8.

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Objective: To investigate whether primary conization might overcome the risk of local dissemination in patients undergoing laparoscopic radical hysterectomy.

Methods: Consecutive data of 262 patients with early stage cervical cancer were retrieved: 88 women had conization followed by radical hysterectomy. A propensity-matched comparison (1:1) was carried out in order to compare laparoscopy and open surgery. Read More

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http://dx.doi.org/10.1002/ijgo.13260DOI Listing

Risk factors and long-term impact of urologic complications during radical hysterectomy for cervical cancer in China, 2004-2016.

Gynecol Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Objective: The primary objective was to describe the incidence and risk factors of urologic complications during radical hysterectomy for cervical cancer. The secondary objective was to investigate the impact of urologic complications on long-term survival.

Methods: Patients who underwent radical hysterectomy for cervical cancer from 2004 to 2016 were identified in the MSCCCC (Major Surgical Complications of Cervical Cancer in China) database. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.029DOI Listing

Quality of life in patients with cervical cancer after open versus minimally invasive radical hysterectomy (LACC): a secondary outcome of a multicentre, randomised, open-label, phase 3, non-inferiority trial.

Lancet Oncol 2020 06;21(6):851-860

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: In the phase 3 LACC trial and a subsequent population-level review, minimally invasive radical hysterectomy was shown to be associated with worse disease-free survival and higher recurrence rates than was open radical hysterectomy in patients with early stage cervical cancer. Here, we report the results of a secondary endpoint, quality of life, of the LACC trial.

Methods: The LACC trial was a randomised, open-label, phase 3, non-inferiority trial done in 33 centres worldwide. Read More

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http://dx.doi.org/10.1016/S1470-2045(20)30081-4DOI Listing

Standardizing Opioid Prescriptions to Patients After Ambulatory Oncologic Surgery Reduces Overprescription.

Jt Comm J Qual Patient Saf 2020 Jul 17;46(7):410-416. Epub 2020 May 17.

Background: Overprescribing of opioids after surgery contributes to long-term abuse. Evaluating opioid prescription patterns and patient-reported opioid use offers an evidence-based method to identify potential overprescription. This quality improvement initiative aimed to reduce and standardize opioid prescriptions upon discharge from an ambulatory oncologic surgery center and evaluate the effect of this change on patients' subsequent opioid use and reported pain. Read More

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http://dx.doi.org/10.1016/j.jcjq.2020.04.004DOI Listing

Radical hysterectomy for early cervical cancer: what shall we do after the LACC trial?

Arch Gynecol Obstet 2020 Aug;302(2):289-292

Department of Obstetrics and Gynaecology, Hanover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Surgical treatment of cervical cancer has led to one of the greatest controversies in gynecological oncology in recent years. After laparoscopic radical hysterectomy became increasingly widespread worldwide, it lost its importance dramatically when the data from the LACC study were published. In contrast to previous assumptions, there was a significantly reduced survival after laparoscopic hysterectomy compared to the open abdominal procedure. Read More

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http://dx.doi.org/10.1007/s00404-020-05627-xDOI Listing

Postoperative comparison of laparoscopic radical resection and open abdominal radical hysterectomy for cervical cancer patient.

Arch Gynecol Obstet 2020 Aug 3;302(2):473-479. Epub 2020 Jun 3.

Department of Obstetrics and Gynaecology, The First People's Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming, 650032, Yunnan, China.

Purpose: There are limited data regarding postoperative complications and autoimmune reactions caused by surgery in early-stage cervical cancer patients who underwent laparoscopic radical resection (LRR). This study aimed to investigate the therapeutic effect of LRR of cervical cancer patients and its effect on cytokines.

Methods: 168 patients with cervical cancer were enrolled. Read More

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http://dx.doi.org/10.1007/s00404-020-05606-2DOI Listing

Delayed Ureteral Leak Related to Use of Suspension Tapes during Laparoscopic Radical Hysterectomy.

J Minim Invasive Gynecol 2020 May 28. Epub 2020 May 28.

Department of Obstetrics and Gynecology, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama (Drs. Chikazawa, Imai, Ito, Kuwata, and Konno).

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http://dx.doi.org/10.1016/j.jmig.2020.05.021DOI Listing

Minimally invasive radical hysterectomy for early-stage cervical cancer: Volume-outcome relationship in the early experience period.

Gynecol Oncol 2020 May 27. Epub 2020 May 27.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Objective: Minimally invasive radical hysterectomy (MIS-RH) for early-stage cervical cancer is a relatively new surgical procedure with increased utilization in the mid-/late-2000s. This study examined the association between hospital surgical volume for MIS-RH and perioperative outcomes for early-stage cervical cancer in the period of early adoption.

Methods: This population-based retrospective study queried the National Inpatient Sample from 2007 to 2011. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.009DOI Listing

The upper limit of optimal tumor size in patients with FIGO 2018 stage IB2 cervical cancer undergoing radical hysterectomy.

Int J Gynecol Cancer 2020 Jul 28;30(7):975-980. Epub 2020 May 28.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Objective: Patients who undergo radical hysterectomy may require postoperative adjuvant radiotherapy, and all efforts should be made to reduce dual therapy in such patients. The aim of this study was to determine the optimal upper limit of tumor size in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB2 cervical cancer who undergo radical hysterectomy.

Methods: We retrospectively reviewed the records of 114 patients with FIGO 2018 stage IB2 cervical cancer who underwent primary surgery either with (n=55) or without (n=59) adjuvant radiotherapy from June 2004 to December 2018. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001271DOI Listing
July 2020
1.949 Impact Factor

Influence of uterine corpus invasion on prognosis in stage IA2-IIB cervical cancer: A multicenter retrospective cohort study.

Gynecol Oncol 2020 May 26. Epub 2020 May 26.

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Objective: To determine the associations between the presence and depth of uterine corpus invasion and survival in patients with cervical cancer.

Methods: Clinical data of patients with stage IA2-IIB cervical cancer who underwent radical hysterectomy between 2004 and 2016 were retrospectively reviewed. Uterine corpus invasion was identified from a review of uterine pathology. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.005DOI Listing

Learning curve could affect oncologic outcome of minimally invasive radical hysterectomy for cervical cancer.

Asian J Surg 2020 May 25. Epub 2020 May 25.

Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.

Background/objective: Recent prospective studies have shown poorer oncologic outcomes following minimally invasive surgery, which has led many surgeons to deeply inspect their practices. We reviewed our experience and evaluated the results of radical hysterectomy in patients with early stage cervical cancer.

Methods: This retrospective study included patients with early stage cervical cancer (Ia1 - IIa1) who were treated with radical hysterectomy from May 2006 to Dec 2016. Read More

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http://dx.doi.org/10.1016/j.asjsur.2020.05.006DOI Listing

Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature.

Aust N Z J Obstet Gynaecol 2020 May 25. Epub 2020 May 25.

Epworth Freemasons Victoria Parade, Melbourne, Victoria, Australia.

Background: The malignant transformation of endometriosis within the ovary is a recognised condition. There is less literature surrounding the malignant transformation of extra-ovarian endometriosis (MEOE).

Aims: We report our experience with MEOE in ten patients and present a review of the literature regarding this rare malignancy. Read More

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http://dx.doi.org/10.1111/ajo.13178DOI Listing

Patterns of recurrence after laparoscopic versus open abdominal radical hysterectomy in patients with cervical cancer: a propensity-matched analysis.

Int J Gynecol Cancer 2020 Jul 23;30(7):987-992. Epub 2020 May 23.

Gynecologic Oncology, Isituto Tumori Milano, Milan, Italy.

Objective: Recent evidence has suggested that laparoscopic radical hysterectomy is associated with an increased risk of recurrence in comparison with open abdominal radical hysterectomy. The aim of our study was to identify patterns of recurrence after laparoscopic and open abdominal radical hysterectomy for cervical cancer.

Methods: This a retrospective multi-institutional study evaluating patients with recurrent cervical cancer after laparoscopic and open abdominal surgery performed between January 1990 and December 2018. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001381DOI Listing
July 2020
1.949 Impact Factor

Is hysterectomy necessary for the treatment of preinvasive stratified mucin producing intraepithelial lesions of the cervix?

Int J Gynecol Cancer 2020 May 23. Epub 2020 May 23.

Department of Gynecologic Oncology, Weill Cornell Medicine, New York, New York, USA.

Objectives: Stratified mucin producing intraepithelial lesion (SMILE) is an uncommon premalignant cervical intraepithelial lesion, characterized by histopathologic features resembling those observed in high grade squamous intraepithelial lesions and adenocarcinoma in situ of the cervix. Its hybrid morphology poses a pathologic challenge with no specific management guidelines. The goal of this study was to review the natural history of SMILE and treatment based outcomes. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001272DOI Listing

Robot-Assisted Nerve-sparing Resection of Bilateral Parametrial Deep Infiltrating Endometriosis.

J Minim Invasive Gynecol 2020 May 19. Epub 2020 May 19.

Department of Human Pathology of the Adult and of the Childhood "Gaetano Barresi," University of Messina, Messina (Dr. Ercoli), Italy.

Objective: To demonstrate the surgical steps used to perform a robotic radical parametrectomy in a woman with deep infiltrating endometriosis.

Design: Description of the procedure using video.

Setting: University hospital, referral center for endometriosis and minimally invasive surgery. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.05.009DOI Listing

What is the impact of radical hysterectomy on endometrial cancer with cervical involvement?

World J Surg Oncol 2020 May 21;18(1):101. Epub 2020 May 21.

Departamento de Ginecología, Instituto Nacional de Cancerología, San Fernando 22, Tlalpan, 14080, Mexico City, Mexico.

Background: When endometrial carcinoma invades the cervical stroma, overall survival and disease-free survival decrease. However, it is still controversial whether patients in suspected stage II should be treated with radical hysterectomy. The goal of this study is to describe the role of radical hysterectomy in patients with endometrial carcinoma and cervical involvement. Read More

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http://dx.doi.org/10.1186/s12957-020-01876-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243320PMC

Imaging features of primary peritoneal serous carcinoma: A case report.

Radiol Case Rep 2020 Jul 12;15(7):978-982. Epub 2020 May 12.

Department of Radiology, Presbyterian Medical Center, 365, Seowon-ro, Wansan-gu, Jeonju-si, Jeollabuk-do, Republic of Korea.

Primary peritoneal serous carcinoma (PPSC) is an epithelial tumor that arises from the peritoneum. On histopathologic analysis, it resembles a malignant ovarian surface epithelial stromal tumor. A 62-year-old woman visited the emergency room with low abdominal pain. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225603PMC

Survival of patients with early-stage cervical cancer after abdominal or laparoscopic radical hysterectomy: a nationwide cohort study and literature review.

Eur J Cancer 2020 Jul 15;133:14-21. Epub 2020 May 15.

Department of Research & Development, Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.

Aim: Recently, the safety of laparoscopic radical hysterectomy (LRH) has been called into question in early-stage cervical cancer. This study aimed to evaluate overall survival (OS) and disease-free survival (DFS) in patients treated with abdominal radical hysterectomy (ARH) and LRH for early-stage cervical cancer and to provide a literature review.

Methods: Patients diagnosed between 2010 and 2017 with International Federation of Gynaecology and Obstetrics (2009) stage IA2 with lymphovascular space invasion, IB1 and IIA1, were identified from the Netherlands Cancer Registry. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.006DOI Listing