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Int J Gynecol Cancer 2019 Feb 13. Epub 2019 Feb 13.

Oncological surgery, Clinica Astorga, Envigado, Colombia.

Background: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy.

Primary Objective: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy. Read More

Ann Surg Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China.

Background: Little data exist about the impact of dissection methods on bladder function during nerve-sparing radical hysterectomy (NSRH). This randomized controlled trial compared the urodynamic and survival outcomes of different methods dissecting the inferior hypogastric plexus (IHP) during laparoscopic NSRH.

Methods: Eligible patients presenting with stage IB cervical cancer from 9 May 2013 to 27 October 2015 were randomized at a ratio of 1:1 and subjected to waterjet (study group) or traditional blunt (control group) dissection of the IHP for laparoscopic type C radical hysterectomy. Read More

Ginekol Pol 2019 ;90(1):20-30

Department of Gynecology, Gynecologic Oncology and Gynecologic Endocrinology, Medical University of Gdansk, Poland.

Objectives: To assess the significance of pathologic ultrastaging (PU) of sentinel (SLN) and non-sentinel (nSLN) lymph nodes (LNs) and the influence on cancer staging in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA2-IB1 cervical cancer.

Material And Methods: A retrospective study was conducted with 54 patients divided into two equal-sized groups. In test group (n1), at least one SLN/patient was detected with blue dye. Read More

Cochrane Database Syst Rev 2019 Feb 12;2:CD012828. Epub 2019 Feb 12.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, 123 Mitraparb Road, Amphur Muang, Khon Kaen, Thailand, 40002.

Background: Radical hysterectomy is one of the standard treatments for stage Ia2 to IIa cervical cancer. Bladder dysfunction caused by disruption of the pelvic autonomic nerves is a common complication following standard radical hysterectomy and can affect quality of life significantly. Nerve-sparing radical hysterectomy is a modified radical hysterectomy, developed to permit resection of oncologically relevant tissues surrounding the cervical lesion, while preserving the pelvic autonomic nerves. Read More

J Gynecol Oncol 2019 Jan 3. Epub 2019 Jan 3.

Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

J Gynecol Oncol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.

Objectives: Nerve-sparing radical hysterectomy has been implemented in order to reduce pelvic floor dysfunctions in women undergoing radical surgery for cervical cancer. Here, we aimed to investigate if the adoption of laparoscopic surgery impacts on patients' outcomes.

Methods: Data of consecutive patients affected by cervical cancer who had laparoscopic nerve-sparing radical hysterectomy were matched 1:1 with an historical cohort of patients undergoing open procedure. Read More

Int Braz J Urol 2019 Jan 25;45. Epub 2019 Jan 25.

Department of Gynae-Oncology, Asian Cancer Institute, Mumbai, India.

We demonstrate robot assisted radical nephrectomy with hysterectomy in the same sitting position followed by specimen retrieval per vagina (NOSE- Natural Orifice Specimen Extraction) A 36 year old female P2L2, presented with long standing dysmenorrhoea. Abdominal sonography detected incidental large left renal mass with a large fundal fibroid. CT scan revealed 8cmx8cm mass arising from mid and lower zone of the left kidney without vascular invasion and lymphadenopathy with a large fundal fibroid. Read More

Eur J Surg Oncol 2019 Jan 30. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, University Hospital of Bern and University of Berne, Berne, Switzerland.

Background: To evaluate sensitivity, false negative rate and negative predictive value of the combination of sentinel lymph node (SLN) mapping and frozen section (FS) in triaging cervical cancer patients to a definitive chemo-radiotherapy.

Methods: A retrospective analysis of patients with histologically proven cervical cancer undergoing laparoscopic SLN mapping and frozen section of the SLNs followed by a completion radical hysterectomy, pelvic and/or paraarotic lymphadenectomy. Sensitivity, false negative rate and negative predictive value of the SLN mapping, of the frozen section and of the combination of the two in identifying micro- and macrometastases were calculated. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Jan 30;234:218-222. Epub 2019 Jan 30.

Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Division of Gynecology, San Carlo di Nancy Hospital, Rome, Italy.

Objective: To investigate the safety, feasibility and oncological adequacy of the Percutaneous Surgical System - PSS in a consecutive series of low-risk endometrial cancer staging.

Study Design: From May 2015 to April 2017, we prospectively performed 30 consecutive percutaneous staging for low/intermediate risk endometrial cancer (FIGO stage IA G1-G2, IB G1-G2, IA G3). All patients were divided in two different groups on the basis of surgical procedure received: Group A included patients submitted to radical Class A hysterectomy and bilateral salpingo-oophorectomy; Group B concerned patients that received a lymph nodal assessment also. Read More

Gynecol Oncol 2019 Feb 2. Epub 2019 Feb 2.

The Ohio State University, James Cancer Hospital, Division of Gynecologic Oncology, 320 West 10(th) Avenue, Columbus, OH 43210, USA. Electronic address:

Objective: The impact of pathologic features of a cone biopsy on the management of women with early stage cervical cancer is understudied. Our objective was to evaluate the additive value of pathologic features of a cone biopsy toward identifying patients with high risk tumors for which adjuvant therapy may be indicated.

Methods: Patients with early stage cervical cancer undergoing a conization followed by radical hysterectomy from 1995 to 2016 were retrospectively identified. Read More

Eur Urol 2019 Feb 1. Epub 2019 Feb 1.

Essen University Hospital, University of Duisburg-Essen, Essen, Germany.

J Vasc Interv Radiol 2019 Feb;30(2):195-202.e1

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea.

Purpose: To compare the efficacy of lymph node (LN) embolization using N-butyl cyanoacrylate versus ethanol sclerotherapy in the management of symptomatic postoperative pelvic lymphorrhea.

Materials And Methods: Thirty-three patients with 40 instances of symptomatic postoperative lymphorrhea were treated with either LN embolization or sclerotherapy at Seoul National University Hospital from January 2009 to July 2017 and were retrospectively included (LN embolization group: 24 lymphoceles of 19 patients, mean age of 59.29 years; sclerotherapy group: 16 lymphoceles of 14 patients, mean age of 60. Read More

J Glob Oncol 2019 Jan(5):1-7

4 Massachusetts General Hospital, Boston, MA.

Purpose: The aim of the study was to evaluate the efficacy of hysterectomy in the control of pelvic disease in patients with post-irradiated residual cervical cancer.

Patients And Methods: Forty patients were treated at either National Institute of Cancer Research and Hospital (NICRH) or Delta Cancer Hospital in Dhaka, Bangladesh, with International Federation of Gynecology and Obstetrics stage IIB to IIIB disease with residual disease after the following: either concurrent chemoradiation with or without brachytherapy, induction chemotherapy and external-beam radiotherapy (EBRT) with or without brachytherapy, or only EBRT. Patients were treated by either radical hysterectomy or extrafascial hysterectomy. Read More

J Clin Med 2019 Jan 30;8(2). Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-0023, Japan.

The current study examined the histology-specific impact of neoadjuvant chemotherapy (NACT) with a taxane/platinum regimen on survival in women with locally-advanced cervical cancer who underwent radical hysterectomy. This nation-wide retrospective cohort study examined women with clinical stage IB2-IIB cervical cancer who received NACT prior to radical hysterectomy from 2004⁻2008 ( = 684). NACT type (taxane/platinum others) was correlated with survival based on histology: 511 squamous 173 non-squamous. Read More

Oncotarget 2018 Dec 28;9(102):37766-37776. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Japan.

Objective: We report a balloon-occluded arterial infusion therapy with an original four-lumen double-balloon catheter (4L-DB) which allows for the efficient injection of an anticancer agent at a high concentration to the target spot for patients with locally advanced uterine cervical cancer.

Methods: One hundred and forty-three patients with locally advanced cervical cancer treated with neoadjuvant intra-arterial chemotherapy (NAIAC) or a primary radical hysterectomy (PRH) were retrospectively assessed. The patients in the NAIAC group received irinotecan 70 mg/m2 intravenously on day 1 and 8 and cisplatin 70 mg/m2 intra-arterially using the 4L-DB on day 2 of a 21-day course, and two courses were performed in principle. Read More

Chin J Cancer Res 2018 Dec;30(6):647-655

Department of Gynecology Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: The aim of this study was to investigate the feasibility of using ultrasonic scalpel combined with vascular clip in parametrial management, called limited energy parametrial resection/dissection (LEPRD), in laparoscopic nerve plane-sparing radical hysterectomy (NPSRH), a modified nerve-sparing radical hysterectomy (NSRH); and to evaluate its effectiveness in pelvic autonomic nerve preservation.

Methods: From July 2012 to January 2016, 257 consecutive patients with stage IB1 to IIA2 cervical cancer who underwent NPSRH were included in this study. Patients were divided into three cohorts according to the different parametrial resection modality. Read More

Oxf Med Case Reports 2019 Jan 24;2019(1):omy115. Epub 2019 Jan 24.

Department of Midwifery, Midwifery School, 'Alexander' Technological Educational Institute of Thessaloniki, PC, Greece.

A 67-year-old woman with post-menopausal bleeding and a suspicious endocervical mass was referred to gynaecology outpatients' for diagnosis and management. Cervical punch biopsies taken showed a benign cervical perivascular epithelioid cell tumour (PEComa), with MRI imaging and PET-CT scan indicating a 3-4 cm endocervical tumour with malignant features. The patient underwent radical hysterectomy with lymph node dissection and the surgical specimen histopathology demonstrated a residual benign PEComa and a stage IIB mesonephric adenocarcinoma (MNA) of the cervix. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2042-2044

Dept. of Surgery, Kurashiki Medical Center.

A 51-year-old woman was referred to our hospitalfor treatment of endometrialcancer. She had 3 family members with colorectal cancer in the first degree. She was also diagnosed with advanced cecal cancer based on a preoperative examination. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14171

Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University of Medicine, Hangzhou, Zhejiang Province, China.

Background: To perform a meta-analysis of high-quality studies comparing robotic radical hysterectomy (RRH) vs laparoscopic radical hysterectomy (LRH), and open radical hysterectomy (ORH) for the treatment of cervical cancer.

Methods: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was performed to identify studies that compared RRH with LRH or ORH. The selection of high-quality, nonrandomized comparative studies was based on a validated tool (methodologic index for nonrandomized studies) since no randomized controlled trials have been published. Read More

J Obstet Gynaecol Res 2019 Jan 22. Epub 2019 Jan 22.

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

Aim: This retrospective study sought to identify the selection criteria required for a non-radical hysterectomy with minimal parametrectomy in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB invasive cervical cancer.

Methods: Overall, 461 patients with FIGO stage IB cervical cancer who underwent a radical hysterectomy were reviewed clinicopathologically according to pathological tumor size (≤2 cm, >2 - ≤4 cm, and > 4 cm).

Results: The pathological parametrial involvement rate in the less than equal to 2 cm group (2%) was significantly lower than in greater than 2-less than equal to 4 cm (13%) or greater than 4 cm (29%) groups (both P < 0. Read More

J Obstet Gynaecol Res 2019 Jan 20. Epub 2019 Jan 20.

Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan.

Aim: To evaluate the clinical relevance of robotic-assisted surgeries (RAS) for gynecologic malignancies in a Japanese multi-institutional cohort.

Methods: A retrospective review of perioperative outcomes of 357 gynecologic RAS procedures was conducted in 24 hospitals accredited to perform RAS by the Japanese Society of Obstetrics and Gynecology (JSOG) over a 4-year period, January 2014 to December 2017.

Results: More than 25 (high), 10-24 (middle) and less than 10 cases (low) were enrolled from 3, 8 and 13 hospitals, respectively. Read More

J Natl Compr Canc Netw 2019 Jan;17(1):86-90

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington.

Minimally invasive surgery (MIS) was previously considered an acceptable alternative to open radical hysterectomy in the management of early-stage cervical cancer (ESCC), but adequately powered, high-quality prospective trials evaluating survival outcomes were lacking. Recently, a large randomized phase III trial, the Laparoscopic Approach to Cervical Cancer (LACC) trial, showed that MIS for ESCC is associated with a higher risk of recurrence and death compared with open surgery. We review the LACC trial findings in depth, as well as a recent National Cancer Database analysis using propensity score weighting that supports the LACC trial findings. Read More

Int J Gynecol Cancer 2019 Jan 18. Epub 2019 Jan 18.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China

BJOG 2019 Jan 18. Epub 2019 Jan 18.

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.

The recent publication of two papers and an editorial in the New England Journal of Medicine (NEJM) has caused consternation in the gynaecological oncology community (4, 5). Both papers demonstrate a worse outcome for patients undergoing radical hysterectomy by the minimal access route compared to open surgery and thus question the dominant paradigm of the last decade that minimal access surgery is the preferred method by which to carry out radical surgery for cervical cancer. These studies raise many questions but the two most pressing are, firstly, have our patients been disadvantaged by our adoption of minimal access surgery and, secondly, how do we proceed as a gynaecological oncology community in the face of these data? This article is protected by copyright. Read More

Oncol Lett 2019 Jan 7;17(1):1101-1107. Epub 2018 Nov 7.

Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214062, P.R. China.

The aim of the present study was to investigate the influence of perineural invasion (PNI) on the prognosis of patients with early cervical cancer (stages IA2-IIA2). A retrospective analysis was conducted on 406 patients with early cervical cancer who underwent a radical hysterectomy and pelvic lymphadenectomy between January 2007 and December 2014 at the Affiliated Hospital of Jiangnan University (Wuxi, China). The clinicopathological data of the patients were obtained and follow-up assessments were performed. Read More

Gynecol Oncol 2019 Jan 12. Epub 2019 Jan 12.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objective: To compare survival outcomes of minimally invasive surgery (MIS) and conventional open surgery for radical hysterectomy (RH) among patients with early-stage cervical cancer (CC).

Methods: We retrospectively identified stage IB1-IIA2 CC patients who underwent either laparoscopic or open Type C RH between 2000 and 2018. Patients' clinicopathologic characteristics and survival outcomes were compared according to the surgical approach. Read More

Int J Surg 2019 Feb 10;62:22-27. Epub 2019 Jan 10.

Clinic for Gynecology, Obstetrics and Gynecological Oncology at the Pius Hospital, University Hospital for Gynecology, Carl von Ossietzky University, Oldenburg, Germany. Electronic address:

Purpose: To evaluate the feasibility of using contained endobags (Morsafe) in the retrieval of the specimen during laparoscopic surgeries in presumably benign myomatous pathology.

Material And Methods: We conducted a retrospective single center case - control study on 239 patients, between 01.05. Read More

J Minim Invasive Gynecol 2019 Jan 9. Epub 2019 Jan 9.

Levine Cancer Institute, Atrium Health, Charlotte, NC. Electronic address:

Lancet 2019 01;393(10167):169-182

Department Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa; South African Medical Research Council, Gynaecological Cancer Research Centre, Tygerberg, South Africa.

Each year, more than half a million women are diagnosed with cervical cancer and the disease results in over 300 000 deaths worldwide. High-risk subtypes of the human papilloma virus (HPV) are the cause of the disease in most cases. The disease is largely preventable. Read More

J Obstet Gynaecol Can 2019 Feb;41(2):143-145

President of GOC, Society of Gynecologic Oncology of Canada.

Surg Res Pract 2018 2;2018:9162921. Epub 2018 Dec 2.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.

Background: An objective of this study was to determine the prognostic role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (CC) stages IA2-IB1.

Methods: The study included 484 patients who underwent radical hysterectomy with pelvic node dissection. The associations of preoperative NLR and PLR with clinicopathologic characteristics and oncological outcomes were analyzed. Read More

Ginekol Pol 2018 ;89(12):667-671

Mersin State Hospital, Department of Obstetrics and Gynecology, Mersin, Turkey.

Objectives: This study was performed to investigate prognostic factors status at smaller tumors in patients with stageIB1 cervical cancer (CC) who underwent modified radical or radical hysterectomy.

Matherial And Metods: Data from patients diagnosed with CC between January 1995 and January 2017 at the GynecologicalOncology Department, Tepecik Training and Research Hospital and Bakirkoy Dr. Sadi Konuk Training and Research Hospital,Istanbul, Turkey, were investigated. Read More

PLoS One 2019 7;14(1):e0210125. Epub 2019 Jan 7.

Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.

Objective: To examine clinico-pathological factors associated with surgical complications and postoperative therapy for clinical stage IB-IIB cervical cancer.

Methods: This nationwide multicenter retrospective study examined women with clinical stage IB-IIB cervical cancer who underwent radical hysterectomy plus pelvic and/or para-aortic lymphadenectomy between 2008-2009 at 87 institutions of the Japanese Gynecologic Oncology Group (n = 693). Multivariate models were used to identify independent predictors of perioperative grade 3-4 complications and bladder dysfunction. Read More

Arch Gynecol Obstet 2019 Jan 4. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Giza, Egypt.

Purpose: To evaluate the effect of a modified type II radical hysterectomy on maternal morbidities and mortality in cases with abnormally invasive placenta (AIP).

Methods: 63 cases with AIP were managed at one of the largest referral centers in Egypt in a prospective study design. This technique entails devascularization of the uterus laterally on both sides and to clamp the uterus at the lowest possible point just below the level of the placenta while sparing the ureters. Read More

Gynecol Oncol Rep 2019 Feb 12;27:38-41. Epub 2018 Dec 12.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon.

A 43-year-old woman treated with radical hysterectomy 1 year ago for cervical cancer presented with a suprapubic abdominal mass. A 15 cm necrotic mass from the abdominal wall along with 2 small bowel loops and the dome of the bladder were resected. The peritoneal defect was reconstructed with a pedicled anterolateral thigh and Vastus Lateralis muscle composite flap. Read More

Climacteric 2019 Feb 2;22(1):27-33. Epub 2019 Jan 2.

b Pôle de Gynécologie, Institut de Recherche Expérimentale et Clinique , Université Catholique de Louvain , Brussels , Belgium.

Uterine fibroids are the most common tumors affecting premenopausal women, responsible for bleeding, pain, and reduced quality of life. When symptomatic, their management mainly involves surgery, which is all too often radical (hysterectomy). While surgical options sparing the uterus (hysteroscopic and laparoscopic myomectomy) and other non-surgical approaches do indeed exist, drug-based therapies are associated with lower costs and morbidity rates. Read More

J Obstet Gynaecol Res 2018 Dec 21. Epub 2018 Dec 21.

Department of Obstetrics and Gynecology, Kansai Rosai Hospital, Amagasaki, Japan.

Aim: A multi-institutional phase II trial was conducted to determine the efficacy and toxicity of neoadjuvant chemotherapy with irinotecan and nedaplatin followed by radical hysterectomy and adjuvant chemotherapy for locally advanced, bulky stage IB2-IIB cervical cancer.

Methods: Patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB2-II, bulky type (>4 cm in diameter) squamous cell carcinoma of the uterine cervix were enrolled. Irinotecan (60 mg/m ) was administered intravenously on days 1 and 8 and nedaplatin (80 mg/m ) was also administered on day 1 of every 21-day cycle. Read More

Pan Afr Med J 2018 16;30:208. Epub 2018 Jul 16.

Service de Radiothérapie, CHU Hassan II Fès, Maroc.

In this paper, we report a case of primary squamous cell carcinoma of the endometrium (PSCCE) with a literature review. A 64-year-old woman was admitted because of postmenopausal bleeding. The gynecological exam found bleeding from the endocervix. Read More

J Obstet Gynaecol Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

Aim: The use of less radical surgery for early stage cervical cancer has often been discussed. To better determine eligible candidates for less radical surgery, we investigated the risk factors for parametrial involvement (PI).

Methods: The study included 193 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical cancer who were treated with radical hysterectomy and pelvic lymphadenectomy between 2008 and 2014. Read More

Clin Case Rep 2018 Dec 5;6(12):2495-2497. Epub 2018 Nov 5.

The Department of Obstetrics and Gynecology Yokohama City University Graduate School of Medicine Yokohama Japan.

Total vaginal cuff dehiscence (VCD) is an important adverse event after hysterectomy. Here, we showed two cases in whom laparoscopic repair of VCD was successful. This procedure is effective, safe, and thus minimally invasive for patients after hysterectomy. Read More

Front Oncol 2018 28;8:568. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China.

With the expansion of value-based medicine, we explore whether using type III hysterectomy to treat low-risk, early-stage cervical cancer constitutes overtreatment. In present study, we evaluate the midterm safety and postoperative quality of life of patients who underwent type II hysterectomy vs. type III hysterectomy with systematic lymphadenectomy for low-risk early-stage cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) IA2-IB1; maximum tumor diameter < 2 cm). Read More

Medicine (Baltimore) 2018 Dec;97(49):e13445

Division of Gynecologic Oncology, Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA.

Background: In cervical cancer, the impact of hospital volume of laparoscopic radical hysterectomy (LRH) has not been investigated systematically as in ovarian cancer.The aim of this study was to investigate the impact of hospital care volume of LRH on treatment outcomes of patients with cervical cancer.

Methods: The PubMed, Embase, and Cochrane Library databases were searched with the terms "cervical cancer," "radical hysterectomy," and "laparoscopy. Read More

Wideochir Inne Tech Maloinwazyjne 2018 Dec 29;13(4):494-500. Epub 2018 Jun 29.

Department of Gynecology, Qingdao Municipal Hospital, Qingdao, China.

Introduction: During the last 3 decades, the standard treatment for stage Ia2-Ib1 cervical cancer has been Piver-Rutledge class II or III radical hysterectomy. However, this surgery is associated with a high rate of urologic morbidity.

Aim: To determine the efficacy of class I radical hysterectomy compared with class III radical hysterectomy in terms of morbidity, overall survival, and patterns of relapse in patients with Ia2-Ib1 cervical cancer undergoing primary surgery. Read More

Curr Probl Cancer 2018 Nov 30. Epub 2018 Nov 30.

Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Mullerian adenosarcoma with sarcomatous overgrowth (MASO) of the uterine cervix is an extremely rare variant of adenosarcoma of the genital tract associated with aggressive clinical course. We searched the PubMed and Medline databases for MASO of the cervix and we identified and reviewed eleven cases published between years 2004 and 2017. The most common clinical picture includes abnormal vaginal bleeding, postcoital bleeding, pelvic pain and foul-smelling vaginal discharge. Read More

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):495-502. Epub 2018 May 9.

Gynecological Oncology Unit, Barcelona Clinic Hospital, 170 Villaroel St, Barcelona 08036, Spain.

Cervical cancer is the fourth most common cancer in women, and seventh overall. This disease represents a medical, economic and social burden. In early FIGO stage patients (IA, IB1 and IIA1), nodal involvement is the most important prognostic factor. Read More

J Obstet Gynaecol Can 2018 Dec 7. Epub 2018 Dec 7.

Division of Gynecologic Oncology, Segal Cancer Centre, Lady Davis Institute of Research, Jewish General Hospital, McGill University, Montreal, QC. Electronic address:

Objective: In view of the recent controversy concerning the use of minimally invasive radical hysterectomy as primary treatment for early stage cervical cancer, this study compared the survival and perioperative outcomes in a cohort of patients who underwent radical hysterectomy either by laparotomy or by robotics.

Methods: This retrospective study compared all consecutive patients with early stage cervical cancer since the beginning of the Division of Gynecologic Oncology at the Jewish General Hospital in 2003, who underwent robotic radical hysterectomy (n = 74) with a cohort of all consecutive patients from the immediate past who underwent open radical hysterectomy (n = 24) for early stage cervical cancer. All patients were treated at the Jewish General Hospital in Montréal (Canadian Task Force Classification II-2). Read More

Cancer Chemother Pharmacol 2018 Dec 1. Epub 2018 Dec 1.

Gynecologic Oncology Unit, Department of Women and Children Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Purpose: The role of dose-dense schedules in the neo-adjuvant treatment (NACT) of locally advanced cervical cancer (LACC) has been reported. This phase II study investigated activity of dose-dense paclitaxel/platinum before radical surgery (RS) in LACC patients.

Methods: The primary end-point was the rate of optimal pathological response (OPR: pathological complete/microscopic response). Read More

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Royal Gwent Hospital, Newport (V.I.S., I.W.T.) Department of Pathology, University Hospital of Wales, Cardiff (G.L.R.) Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital, Birmingham (V.P.S.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK.

Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Read More

Cancer Manag Res 2018 19;10:5927-5935. Epub 2018 Nov 19.

Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan 430071, Hubei, People's Republic of China,

Purpose: The aim of this study was to investigate the impact of vaginal cuff length (VCL) resected during radical hysterectomy (RH) on the long-term survival outcomes of patients with cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] stage IB-IIA) and to explore whether VCL is a prognostic factor for cervical cancer.

Methods: A total of 435 eligible patients with stage IB and IIA cervical cancer who underwent RH in Zhongnan Hospital of Wuhan University (Wuhan, People's Republic of China) from January 2007 to February 2017 were retrospectively analyzed. These patients were divided into two groups (VCL ≤2. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13420

Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.

Rationale: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended.

Patient Concerns: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. Read More