24 results match your criteria Radiation-Induced Lumbosacral Plexopathy

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Second pelvic recurrence of rectal cancer successfully treated with a re-reirradiation (3rd radiation course).

Tumori 2018 Apr 1:300891618763206. Epub 2018 Apr 1.

1 Division of Radiation Oncology, European Institute of Oncology, Milan, Italy.

Introduction: In case of pelvic recurrence of colorectal cancer, reirradiation of previously irradiated patients may increase the rate of salvage radical resection. Due to the high cumulative dose, one of the main concerns is radiation-induced lumbosacral plexopathy. This report describes multiple irradiations of a lesion adjacent to the lumbosacral plexus, using a highly selective technique, which allows optimal sparing of such a critical structure. Read More

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http://journals.sagepub.com/doi/full/10.1177/030089161876320
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http://dx.doi.org/10.1177/0300891618763206DOI Listing
April 2018
7 Reads

[Radiation-induced lumbosacral plexopathy with severe burning pain after 17 years of radiation therapy for cervical cancer: a case report].

Rinsho Shinkeigaku 2015 7;55(9):654-6. Epub 2015 Jul 7.

Department of Neurology, The Jikei University School of Medicine.

A 73-year-old woman was admitted with severe burning pain, hyperesthesia, and weakness in the right lower extremity. The patient had undergone radio- and chemotherapy after surgery for cervical cancer 17 years earlier. We diagnosed radiation-induced lumbosacral plexopathy because of conduction block in the deep peroneal nerve and myokymic discharge in the tibialis anterior muscle. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-000706DOI Listing
April 2016
13 Reads

Lumbosacral plexus delineation, dose distribution, and its correlation with radiation-induced lumbosacral plexopathy in cervical cancer patients.

Onco Targets Ther 2015 23;8:21-7. Epub 2014 Dec 23.

Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Background: To evaluate the dose distribution to the lumbosacral plexus (LSP) and its correlation with radiation-induced lumbosacral plexopathy (RILSP) in patients with cervical cancer treated with intensity-modulated radiotherapy (IMRT) and high-dose-rate brachytherapy.

Materials And Methods: After meeting eligibility criteria, 50 patients with cervical cancer were selected who were treated with IMRT and high-dose-rate brachytherapy, and the LSP was contoured. Mean volume; percentages of LSP volume absorbing 40, 50, 55, and 60 Gy (V30, V40, V50, V55, and V60) and point doses (P1, P2, P3, P4, P5, P6, P7, P8, P9, and P10); and RILSP incidence were calculated. Read More

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http://dx.doi.org/10.2147/OTT.S71086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278780PMC
January 2015
12 Reads
1.342 Impact Factor

Lumbosacral plexopathy: A rare long term complication of concomitant chemo-radiation for cervical cancer.

Gynecol Oncol Res Pract 2015 4;2:12. Epub 2015 Dec 4.

Department of Radiotherapy, National Oncology Institute, Ibn Sina University Hospital, Mohamed 5 Souissi University, Rabat, Morocco.

Radiation induced Lumbosacral plexophaty (RILP) is a rare but severe complication that has a considerable impact on quality of life. Its occurrence is rare but increasing with improved long-term cancer survival. This entity commonly results in different degrees of sensory and motor deficits. Read More

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http://dx.doi.org/10.1186/s40661-015-0019-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881179PMC
May 2016
13 Reads

External validation of the lumbosacral plexus-contouring protocol developed by Yi et al. (IJROBP 2012; 84: 376-82) for pelvic malignancies.

J Med Imaging Radiat Oncol 2014 Feb 29;58(1):117-24. Epub 2013 Aug 29.

Alan Walker Cancer Centre, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Purpose: To evaluate interobserver variability in contouring lumbosacral plexuses (LSP) using the protocol developed by Yi et al. (IJROBP 2012; 84: 376-82) and to review LSP dosimetries for conventional radiotherapy and intensity-modulated radiotherapy (IMRT) for pelvic cancers.

Methods And Materials: Using the above-mentioned protocol, seven outliners independently contoured LSPs of 10 consecutive patients (five patients treated with conventional radiotherapy and five with IMRT). Read More

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http://doi.wiley.com/10.1111/1754-9485.12106
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http://dx.doi.org/10.1111/1754-9485.12106DOI Listing
February 2014
24 Reads

Late radiation injury to peripheral nerves.

Handb Clin Neurol 2013 ;115:743-58

Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, Paris, France. Electronic address:

Although the peripheral nerve has often been considered as radioresistant, clinical practice demonstrates the occurrence of radiation-induced peripheral neuropathies. Because these complications appear late, usually several years after the course of radiotherapy, their occurrence is explained by improvement in the prognosis of several cancers. Their physiopathology is not fully understood. Read More

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http://dx.doi.org/10.1016/B978-0-444-52902-2.00043-6DOI Listing
April 2014
19 Reads

Radiation-induced neuropathy in cancer survivors.

Radiother Oncol 2012 Dec;105(3):273-82

Oncologie-Radiothérapie, Hôpital saint Louis, APHP, Paris, France.

Radiation-induced peripheral neuropathy is a chronic handicap, frightening because progressive and usually irreversible, usually appearing several years after radiotherapy. Its occurrence is rare but increasing with improved long-term cancer survival. The pathophysiological mechanisms are not yet fully understood. Read More

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http://dx.doi.org/10.1016/j.radonc.2012.10.012DOI Listing
December 2012
52 Reads

Neurological Adverse Effects after Radiation Therapy for Stage II Seminoma.

Case Rep Oncol 2012 May 15;5(2):444-8. Epub 2012 Aug 15.

Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

We report 3 cases of patients with testicular cancer and stage II seminoma who developed neurological symptoms with bilateral leg weakness about 4 to 9 months after radiation therapy (RT). They all received RT to the para-aortic lymph nodes with a total dose of 40 Gy (36 Gy + 4 Gy as a boost against the tumour bed) with a conventional fractionation of 2 Gy/day, 5 days per week. RT was applied as hockey-stick portals, also called L-fields. Read More

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http://dx.doi.org/10.1159/000341874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433016PMC
May 2012
9 Reads

[Radiation-induced neuropathies: collateral damage of improved cancer prognosis].

Rev Neurol (Paris) 2012 Dec 27;168(12):939-50. Epub 2012 Jun 27.

Département des maladies du système nerveux, hôpital Pitié-Salpêtrière, groupe hospitalier Pitié-Salpêtrière, 47 boulevard de l'Hôpital, Paris, France.

Introduction: Because of the improvement of cancer prognosis, long-term damages of treatments become a medical and public health problem. Among the iatrogenic complications, neurological impairment is crucial to consider since motor disability and pain have a considerable impact on quality of life of long cancer survivors. However, radiation-induced neuropathies have not been the focus of great attention. Read More

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http://dx.doi.org/10.1016/j.neurol.2011.11.013DOI Listing
December 2012
65 Reads

Clinical, Electrophysiological Findings in Adult Patients with Non-traumatic Plexopathies.

Ann Rehabil Med 2011 Dec 30;35(6):807-15. Epub 2011 Dec 30.

Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

Objective: To ascertain the etiology of non-traumatic plexopathy and clarify the clinical, electrophysiological characteristics according to its etiology.

Method: We performed a retrospective analysis of 63 non-traumatic plexopathy patients that had been diagnosed by nerve conduction studies (NCS) and needle electromyography (EMG). Clinical, electrophysiological, imaging findings were obtained from medical records. Read More

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http://dx.doi.org/10.5535/arm.2011.35.6.807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309383PMC
December 2011
14 Reads

Development of a standardized method for contouring the lumbosacral plexus: a preliminary dosimetric analysis of this organ at risk among 15 patients treated with intensity-modulated radiotherapy for lower gastrointestinal cancers and the incidence of radiation-induced lumbosacral plexopathy.

Int J Radiat Oncol Biol Phys 2012 Oct 17;84(2):376-82. Epub 2012 Feb 17.

Department of Radiation Oncology, University of California, Davis Cancer Center, Sacramento, CA 95817, USA.

Purpose: To generate a reproducible step-wise guideline for the delineation of the lumbosacral plexus (LSP) on axial computed tomography (CT) planning images and to provide a preliminary dosimetric analysis on 15 representative patients with rectal or anal cancers treated with an intensity-modulated radiotherapy (IMRT) technique.

Methods And Materials: A standardized method for contouring the LSP on axial CT images was devised. The LSP was referenced to identifiable anatomic structures from the L4-5 interspace to the level of the sciatic nerve. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S036030161103632
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http://dx.doi.org/10.1016/j.ijrobp.2011.11.074DOI Listing
October 2012
32 Reads

Radiotherapy-induced lumbosacral plexopathy in a patient with cervical cancer: a case report and literature review.

Contemp Oncol (Pozn) 2012 29;16(2):194-6. Epub 2012 May 29.

Gynaecology Oncology Department, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Kraków, Poland.

Radiotherapy-induced lumbosacral plexopathy in cervical cancer treatment is a very rare, but extremely serious complication. The clinical course is associated with severe bilateral lower leg pain, reduced sensation, different degrees of weakness, paresis or paralysis, and sometimes also urinary or fecal incontinence. Patient quality of life becomes significantly deteriorated. Read More

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http://dx.doi.org/10.5114/wo.2012.28805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687391PMC
June 2013
10 Reads

Endometrial stromal sarcoma metastasis to the lumbar spine and sphenoid bone.

Rare Tumors 2011 Jul 21;3(3):e27. Epub 2011 Oct 21.

Department of Neurological Surgery, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio;

Endometrial stromal sarcoma (ESS) is typically associated with metastasis to the abdomen, pelvis, and lung. We found three case reports of ESS metastasis to the bone (two to the thoracic spine, and one to the parietal bone). Our objective is to review the literature on ESS spinal and intracranial metastases and, report the first case of ESS metastatic to the lumbar paraspinal region and sphenoid bone. Read More

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http://journals.sagepub.com/doi/10.4081/rt.2011.e27
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http://dx.doi.org/10.4081/rt.2011.e27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208414PMC
July 2011
11 Reads

Neurologic manifestations of neoplastic and radiation-induced plexopathies.

Authors:
Kurt A Jaeckle

Semin Neurol 2010 Jul 24;30(3):254-62. Epub 2010 Jun 24.

Department of Neurology and Oncology, Mayo Clinic Florida, Jacksonville, Florida 32224, USA.

Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer, and may involve any of the peripheral nerve plexuses. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas. Neoplastic plexopathy is often characterized initially by severe, unrelenting pain followed by development of weakness and focal sensory disturbances. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0030-1255219
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http://dx.doi.org/10.1055/s-0030-1255219DOI Listing
July 2010
17 Reads

Neurotoxicity of radiation therapy.

Authors:
Edward J Dropcho

Neurol Clin 2010 Feb;28(1):217-34

Department of Neurology, Indiana University Medical Center, CL 292, Indianapolis, IN 46202, USA.

Direct or incidental exposure of the nervous system to therapeutic irradiation carries the risk of symptomatic neurologic injury. Central nervous system toxicity from radiation includes focal cerebral necrosis, neurocognitive deficits, and less commonly cerebrovascular disease, myelopathy, or the occurrence of a radiation-induced neoplasm. Brachial or lumbosacral plexopathy are the most common syndromes of radiation toxicity affecting the peripheral nervous system. Read More

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http://dx.doi.org/10.1016/j.ncl.2009.09.008DOI Listing
February 2010
7 Reads

[Radiation myelopathy and plexopathy].

Brain Nerve 2008 Feb;60(2):115-21

Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan.

Radiation myelopathy (RM) is a relatively rare disorder characterized by white matter lesions of the spinal cord resulting from irradiation. It is divided into two forms by the latent periods: transient RM and delayed RM. The delayed RM develops usually non-transverse myelopathy symptoms such as dissociated sensory disturbance, unilateral leg weakness, and gait disturbance with asymmetric steps. Read More

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February 2008
9 Reads

Radiation-induced lumbo-sacral plexopathy (RILSP): an important enigma.

Clin Oncol (R Coll Radiol) 2006 Jun;18(5):427-8

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June 2006
6 Reads

Neurological manifestations of neoplastic and radiation-induced plexopathies.

Authors:
Kurt A Jaeckle

Semin Neurol 2004 Dec;24(4):385-93

Department of Neurology and Oncology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer and may involve any of the peripheral nerve plexuses. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas. Regardless of the location, neoplastic plexopathy is often characterized by severe, unrelenting pain. Read More

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http://dx.doi.org/10.1055/s-2004-861533DOI Listing
December 2004
10 Reads

Acute lower extremity paralysis following radiation therapy for cervical cancer.

Gynecol Oncol 1999 Oct;75(1):152-4

Department of Obstetrics and Gynecology, Cook County Hospital, Chicago, Illinois, 60612, USA.

Background: Acute lower extremity paralysis secondary to lumbosacral plexopathy is a rare but severe complication that may follow pelvic radiotherapy for cervical cancer.

Case: A 49-year-old female with newly diagnosed stage IIIB cervical cancer developed progressive bilateral lower extremity paralysis and pelvic pain only 10 weeks following completion of radiation therapy for cervical cancer with no evidence of metastasis or progression of disease. Her bladder and bowel function were not affected. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S009082589995561
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http://dx.doi.org/10.1006/gyno.1999.5561DOI Listing
October 1999
6 Reads

Fecal incontinence after pelvic radiotherapy: evidences for a lumbosacral plexopathy. Report of a case.

Dis Colon Rectum 1996 Apr;39(4):465-7

Service de Gastro-Entérologie Hôpital Saint-Lazare, Paris, France.

Purpose: Clinical manifestations of radiation-induced lumbosacral plexopathy remain a rare event. We report the case of a 62-year-old woman with neurogenic fecal incontinence that occurred after radiotherapy of cervical carcinoma.

Methods: Anorectal, bladder, and lower limb sensory-motor functions, as biologic and morphologic explorations, were performed on repeated occasions. Read More

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April 1996
6 Reads

Radiation induced lumbosacral plexopathy in gynecologic tumors: clinical findings and dosimetric analysis.

Int J Radiat Oncol Biol Phys 1993 Jun;26(3):479-82

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.

Purpose: Radiation-induced lumbosacral plexopathy is a rare complication of pelvic irradiation.

Methods And Materials: We report four cases among 2,410 patients treated to the pelvis for carcinoma of the cervix and carcinoma of the endometrium. All patients received both external beam and intracavitary radiation. Read More

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June 1993
8 Reads

Nerve plexus metastases.

Authors:
K A Jaeckle

Neurol Clin 1991 Nov;9(4):857-66

Department of Neurology, University of Utah, Salt Lake City.

Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer and may involve any of the peripheral nerve plexus. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas. Regardless of the location, carcinomatous plexopathy typically is associated with severe unrelenting pain as the cardinal clinical feature. Read More

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November 1991
27 Reads

[A case of delayed radiation lumbo-sacral plexopathy].

No To Shinkei 1990 Jul;42(7):629-33

Department of Neurology, Tokyo Women's Medical College, Japan.

We report a 47-year-old woman who developed a slowly progressive lumbosacral plexopathy with mixed sensorimotor losses in the lower extremities. The symptoms were apparent 8 years after x-ray irradiation for an ovarian carcinoma. Neurological examination showed mild weakness and absent deep tendon reflexes of bilateral lower extremities, and hypesthesia to all modalities in anterior aspects of bilateral lower thighs, in dorsum pedis and soles. Read More

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July 1990
5 Reads

Diagnosis and treatment of lumbosacral plexopathies in patients with cancer.

Arch Neurol 1984 Dec;41(12):1282-5

Eleven patients were diagnosed as having lumbosacral plexopathy at M. D. Anderson Hospital, Houston, from August 1981 through July 1982. Read More

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December 1984
8 Reads
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