42 results match your criteria Radiation-Induced Brachial Plexopathy

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Microneurosurgical treatment options in peripheral nerve compression syndromes after chemotherapy and radiation treatment.

J Surg Oncol 2018 Oct 27;118(5):793-799. Epub 2018 Sep 27.

The Institute for Advanced Reconstruction at The Plastic Surgery Center, Shrewsbury, New Jersey.

Chemotherapy-induced peripheral neuropathy and radiation-induced brachial plexopathy are extremely debilitating conditions which can occur after treatment of malignancy. Unfortunately, the diagnosis can be elusive, and this dilemma is further compounded by the lack of efficacious therapeutics to prevent the onset of neurotoxicity before initiating chemotherapy or radiation or to treat these sequelae after treatment. However, microsurgical nerve decompression can provide these patients with a viable option to treat this complication. Read More

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http://dx.doi.org/10.1002/jso.25254DOI Listing
October 2018
6 Reads

Early transient radiation-induced brachial plexopathy in locally advanced head and neck cancer.

Contemp Oncol (Pozn) 2016 16;20(1):67-72. Epub 2016 Mar 16.

Department of Radiation Oncology, Eskisehir Osmangazi University School of Medicine, Turkey.

Aim Of The Study: Early transient brachial plexopathy following radiotherapy (RT) in patients with head and neck cancer may be underreported and associated with a dose-response. Our purpose was to determine the incidence of early transient radiation-ınduced brachial plexopathy (RIBP) in patients receiving primary RT (± chemotherapy) for locally advanced head and neck cancer (HNC).

Material And Methods: Twenty-seven locally advanced HNC patients who have no finding of brachial plexopathy at the diagnosis were evaluated 3 times by a specifically developed 13-item questionnaire for determining early transient RIBP. Read More

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http://dx.doi.org/10.5114/wo.2015.55876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829741PMC
April 2016
14 Reads

Clinical Utility of (18)F-FDG PET/CT in brachial plexopathy secondary to metastatic breast cancer.

Indian J Nucl Med 2016 Apr-Jun;31(2):123-7

Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.

Role of fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in breast cancer is rapidly evolving. Brachial plexopathy is a rare clinical entity in follow-up of operated breast cancer patients, who presents with disease recurrence in the axilla. Conventionally, magnetic resonance imaging is the imaging modality of choice for diagnostic evaluation in these cases and only few case reports/short studies have explored the utility of PET/CT in this clinical indication. Read More

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http://dx.doi.org/10.4103/0972-3919.178263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815384PMC
April 2016
8 Reads

Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study.

Oncotarget 2016 Apr;7(14):18887-95

Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Radiation-induced brachial plexopathy (RIBP) is one of the late complications in nasopharyngeal carcinoma (NPC) patients who received radiotherapy. We conducted a retrospective study to investigate its clinical characteristics and risk factors.Thirty-onepatients with RIBP after radiotherapy for NPC were enrolled. Read More

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http://dx.doi.org/10.18632/oncotarget.7748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951337PMC
April 2016
23 Reads

Brachial plexus dose tolerance in head and neck cancer patients treated with sequential intensity modulated radiation therapy.

Radiat Oncol 2015 Apr 18;10:94. Epub 2015 Apr 18.

Department of Radiation Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, 251 East Huron, LC-178, Chicago, IL, 60611, USA.

Purpose: We aimed to study the radiation induced brachial plexopathy in patients with head and neck squamous cell carcinoma (HNSCC) treated with Sequential Intensity Modulated Radiation Therapy (S-IMRT).

Methods And Materials: This IRB approved study included 68 patients with HNSCC treated consecutively. Detailed dose volume histogram data was generated for ipsilateral and contralateral brachial plexus (BP) volumes receiving a specified dose (Vds) i. Read More

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http://dx.doi.org/10.1186/s13014-015-0409-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464874PMC
April 2015
9 Reads

Dosimetric analysis of the brachial plexus among patients with breast cancer treated with post-mastectomy radiotherapy to the ipsilateral supraclavicular area: report of 3 cases of radiation-induced brachial plexus neuropathy.

Radiat Oncol 2014 Dec 12;9:292. Epub 2014 Dec 12.

Department of Radiation Oncology, Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.

Background: The purpose of this study was to evaluate the brachial plexus (BP) dose of postmastectomy radiotherapy (PMRT) to the ipsilateral supraclavicular (ISCL) area, and report the characteristics of radiation-induced brachial plexus neuropathy (RIBPN).

Methods: The BP dose of 31 patients who received adjuvant PMRT to the ISCL area and chest wall using three-dimensional conformal radiotherapy (3DCRT) and the records of 3 patients with RIBPN were retrospectively analyzed based on the standardized Radiation Therapy Oncology Group-endorsed guidelines. The total dose to the ISCL area and chest wall was 50 Gy in 25 fractions. Read More

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http://dx.doi.org/10.1186/s13014-014-0292-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271326PMC
December 2014
45 Reads

Free functioning muscle transfer in radiation-induced brachial plexopathy: case report.

J Hand Surg Am 2014 Oct 22;39(10):1967-70. Epub 2014 Aug 22.

Department of Orthopedics, Ogori Daiichi General Hospital, Yamaguchi, Japan.

Radiation-induced brachial plexopathy is a delayed complication of radiation treatment for tumors involving the neck and chest area and is progressive. A 56-year-old woman presented to us with loss of elbow flexion and weak wrist and finger extension 15 years after she received external beam radiation to the left chest, axilla, and supraclavicular region for treatment of breast cancer. She was managed with a gracilis free muscle transfer for elbow flexion and hand prehension. Read More

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http://dx.doi.org/10.1016/j.jhsa.2014.06.128DOI Listing
October 2014
18 Reads

External evaluation of the Radiation Therapy Oncology Group brachial plexus contouring protocol: several issues identified.

J Med Imaging Radiat Oncol 2014 9;58(3):360-8. Epub 2014 Apr 9.

Alan Walker Cancer Centre, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Introduction: The aims of the study were to evaluate interobserver variability in contouring the brachial plexus (BP) using the Radiation Therapy Oncology Group (RTOG)-approved protocol and to analyse BP dosimetries.

Methods: Seven outliners independently contoured the BPs of 15 consecutive patients. Interobserver variability was reviewed qualitatively (visually by using planning axial computed-tomography images and anteroposterior digitally reconstructed radiographs) and quantitatively (by volumetric and statistical analyses). Read More

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http://doi.wiley.com/10.1111/1754-9485.12175
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http://dx.doi.org/10.1111/1754-9485.12175DOI Listing
April 2015
18 Reads

Whole-Field Sequential Intensity-Modulated Radiotherapy for Local-Regional Advanced Head-and-Neck Squamous Cell Carcinoma.

Am J Clin Oncol 2015 Dec;38(6):588-94

Departments of *Radiation Oncology ‡Medicine, Division of Hematology/Oncology §Otolaryngology, Head and Neck Surgery ∥Preventive Medicine, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL †Department of Clinical Oncology, Alexandria University, Alexandria, Egypt.

Purpose: There is little published data on the technique and results of whole-field (WF) sequential intensity-modulated radiotherapy (S-IMRT) for patients with head-and-neck squamous cell carcinoma (HNSCC). We report the treatment outcomes, adverse events (AEs), and dosimetric parameters in local-regional advanced (LRA) HNSCC patients treated with the WF S-IMRT technique.

Methods: The IRB approved this retrospective study. Read More

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http://dx.doi.org/10.1097/COC.0000000000000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713122PMC
December 2015
16 Reads

Radiation-induced neuropathy in cancer survivors.

Radiother Oncol 2012 Dec;105(3):273-82

Oncologie-Radiothérapie, Hôpital saint Louis, APHP, Paris, France.

Radiation-induced peripheral neuropathy is a chronic handicap, frightening because progressive and usually irreversible, usually appearing several years after radiotherapy. Its occurrence is rare but increasing with improved long-term cancer survival. The pathophysiological mechanisms are not yet fully understood. Read More

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http://dx.doi.org/10.1016/j.radonc.2012.10.012DOI Listing
December 2012
52 Reads

Managing the consequences of cancer treatment and the English National Cancer Survivorship Initiative.

Authors:
E J Maher

Acta Oncol 2013 Feb 13;52(2):225-32. Epub 2012 Dec 13.

Mount Vernon Cancer Centre, Northwood, Middlesex, UK.

Background: In 2007 the English National Cancer Survivorship initiative was launched as a partnership between a national charity, Macmillan Cancer Support, the English Department of Health (DH) and the quality improvement agency NHS Improvement. The initiative involved a number of work streams, one of which was to improve the detection and management of the Consequences of adult cancer Treatment (COT).

Material And Methods: The adult COT group took evidence from a range of stakeholders and published a vision and work programme focused on awareness raising, linking self- administered questionnaires to routine activity data collection and testing new models of care with a particular focus on pelvic cancers. Read More

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http://dx.doi.org/10.3109/0284186X.2012.746467DOI Listing
February 2013
8 Reads

[Radiation-induced neuropathies: collateral damage of improved cancer prognosis].

Rev Neurol (Paris) 2012 Dec 27;168(12):939-50. Epub 2012 Jun 27.

Département des maladies du système nerveux, hôpital Pitié-Salpêtrière, groupe hospitalier Pitié-Salpêtrière, 47 boulevard de l'Hôpital, Paris, France.

Introduction: Because of the improvement of cancer prognosis, long-term damages of treatments become a medical and public health problem. Among the iatrogenic complications, neurological impairment is crucial to consider since motor disability and pain have a considerable impact on quality of life of long cancer survivors. However, radiation-induced neuropathies have not been the focus of great attention. Read More

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http://dx.doi.org/10.1016/j.neurol.2011.11.013DOI Listing
December 2012
65 Reads

Brachial plexopathy in apical non-small cell lung cancer treated with definitive radiation: dosimetric analysis and clinical implications.

Int J Radiat Oncol Biol Phys 2013 Jan 1;85(1):175-81. Epub 2012 Jun 1.

Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Purpose: Data are limited on the clinical significance of brachial plexopathy in patients with apical non-small cell lung cancers (NSCLC) treated with definitive radiation therapy. We report the rates of radiation-induced brachial plexopathy (RIBP) and tumor-related brachial plexopathy (TRBP) and associated dosimetric parameters in apical NSCLC patients.

Methods And Materials: Charts of NSCLC patients with primary upper lobe or superiorly located nodal disease who received ≥50 Gy of definitive conventionally fractionated radiation or chemoradiation were retrospectively reviewed for evidence of brachial plexopathy and categorized as RIBP, TRBP, or trauma-related. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2012.03.051DOI Listing
January 2013
26 Reads

Dose constraints to prevent radiation-induced brachial plexopathy in patients treated for lung cancer.

Int J Radiat Oncol Biol Phys 2012 Mar;82(3):e391-8

Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

Purpose: As the recommended radiation dose for non-small-cell lung cancer (NSCLC) increases, meeting dose constraints for critical structures like the brachial plexus becomes increasingly challenging, particularly for tumors in the superior sulcus. In this retrospective analysis, we compared dose-volume histogram information with the incidence of plexopathy to establish the maximum dose tolerated by the brachial plexus.

Methods And Materials: We identified 90 patients with NSCLC treated with definitive chemoradiation from March 2007 through September 2010, who had received >55 Gy to the brachial plexus. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2011.06.1961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786565PMC
March 2012
10 Reads

Brachial plexopathy after chemoradiotherapy for head and neck squamous cell carcinoma.

Strahlenther Onkol 2010 Sep 30;186(9):517-20. Epub 2010 Aug 30.

Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium.

Purpose: To evaluate late brachial plexopathy after primary chemoradiotherapy for locally advanced head and neck squamous cell carcinoma.

Patients And Methods: Consecutive 43 disease-free patients were evaluated by a specifically developed 26-item questionnaire. Retrospectively, the brachial plexus was delineated and the dose-volume histograms were calculated. Read More

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http://dx.doi.org/10.1007/s00066-010-2099-0DOI Listing
September 2010
8 Reads

Brachial neuropathy 22 years after radiation therapy for fibrosarcoma: a case report.

Cases J 2009 Sep 15;2:6838. Epub 2009 Sep 15.

Department of Plastic and Reconstructive Surgery, Soft Tissue Tumour Reference Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum Buerkle-de-la Camp Platz 1, 44789 Bochum Germany.

This case report presents a 56-year-old man with right upper limb weakness which arose 22 years after initial local radiation treatment for a grade III fibrosarcoma. Nerve conduction studies revealed impairment of all three major upper limb nerves compared with the left, with particular impairment of the median and ulnar nerves in the most fibrotic area that had been irradiated. In addition, the patient received multiple courses of chemotherapy. Read More

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http://dx.doi.org/10.4076/1757-1626-2-6838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769320PMC
September 2009
9 Reads

Nerve transfer for elbow flexion in radiation-induced brachial plexopathy: a case report.

Hand (N Y) 2009 Jun 9;4(2):123-8. Epub 2008 Oct 9.

Division of Plastic & Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St. Louis, MO 63110, USA.

Radiation-induced brachial plexopathy is an uncommon but devastating late complication seen in patients receiving radiation therapy to the chest wall and axilla. Treatment options are unfortunately limited. We report a case of a 59-year-old woman treated with radiation therapy for breast cancer 12 years earlier, who presented with loss of elbow flexion and marked shoulder weakness. Read More

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http://dx.doi.org/10.1007/s11552-008-9136-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686782PMC
June 2009
29 Reads

[Radiation myelopathy and plexopathy].

Brain Nerve 2008 Feb;60(2):115-21

Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan.

Radiation myelopathy (RM) is a relatively rare disorder characterized by white matter lesions of the spinal cord resulting from irradiation. It is divided into two forms by the latent periods: transient RM and delayed RM. The delayed RM develops usually non-transverse myelopathy symptoms such as dissociated sensory disturbance, unilateral leg weakness, and gait disturbance with asymmetric steps. Read More

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February 2008
9 Reads

Radiation-induced brachial plexopathy and hypofractionated regimens in adjuvant irradiation of patients with breast cancer--a review.

Acta Oncol 2006 ;45(3):280-4

Department of Radiotherapy, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, W. K. Roentgen 5, 02-781, Warsaw, Poland.

In order to increase the availability of adjuvant radiotherapy of breast cancer patients and make it more convenient and cheaper, in numerous cancer centres, the dose per fraction has been increased from 2 Gy to 2.25-2.75 Gy and the total dose has been decreased from 50 Gy to 40-45 Gy. Read More

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http://dx.doi.org/10.1080/02841860500371907DOI Listing
November 2006
5 Reads

Radiation-induced conduction block: resolution following anticoagulant therapy.

Authors:
Oscar Soto

Muscle Nerve 2005 May;31(5):642-5

Neurology Department, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain.

Neurophysiologic studies documented proximal conduction blocks in a patient harboring a delayed radiation-induced brachial plexopathy. Since anticoagulants have been reported to be beneficial in radiation-induced neuropathies, the patient was started on acenocumarol. After 3 months of treatment there was significant improvement of clinical deficits, which correlated with resolution of conduction blocks. Read More

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http://dx.doi.org/10.1002/mus.20273DOI Listing
May 2005
9 Reads

Radiation-induced brachial plexopathy: review. Complication without a cure.

J Reconstr Microsurg 2004 Feb;20(2):149-52

Harvard Medical School, Boston, MA 02114, USA.

Radiation-induced brachial plexopathy, especially the chronic and progressive form, has become an increasingly rare entity in patients receiving radiation therapy to the chest wall and axilla. However, for the patients affected by this pathologic process, the chronic pain, decline in function, and absence of a satisfactory treatment are a continuing challenge to the reconstructive peripheral nerve surgeon. The authors have undertaken a review of the relevant literature addressing radiation-induced brachial plexopathy, and here present a summary of the current understanding of the pathophysiology, diagnosis, and treatment of this disorder. Read More

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http://dx.doi.org/10.1055/s-2004-820771DOI Listing
February 2004
5 Reads

A patient questionnaire for radiation-induced brachial plexopathy.

Am J Clin Oncol 2004 Feb;27(1):1-7

Department of Radiotherapy and Radiooncology, University Hospital Eppendorf, Hamburg, Germany.

We analyzed the usefulness of a symptom questionnaire to screen for radiation-induced brachial plexopathy (RIBP) after breast cancer treatment. Four questions addressed distal and proximal paresis: impaired hand functions, problems raising the arm, carrying weights, and lifting objects from a high shelf. Eighty-one relapse-free patients were neurologically examined. Read More

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http://pdfs.journals.lww.com/amjclinicaloncology/2004/02000/
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February 2004
13 Reads

Diagnosis and operative treatment of radiation-induced brachial plexopathy.

Chin J Traumatol 2002 Dec;5(6):329-32

Department of Hand Surgery, First Hospital Affiliated to Jilin University, Changchun 130021, China.

Objective: To explore the diagnosis and operative treatment of radiation-induced brachial plexopathy.

Methods: Nine cases of radiation-induced brachial plexopathy were divided into two groups, 4 cases undergoing neurolysis of brachial plexus as Group A and 5 cases undergoing transfer of myocutaneous flaps after neurolysis as Group B. In Group B, 4 cases were treated with latissimus dorsi myocutaneous flaps (about 20 cm x 20 cm) and 1 case with pectoralis major myocutaneous flap (about 8 cm x 6 cm). Read More

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December 2002
8 Reads

Radiation-induced brachial plexopathy in women treated for carcinoma of the breast.

Clin Rehabil 2002 Mar;16(2):160-5

Department of Neurology, Derriford Hospital, Plymouth, UK.

Objectives: To study the clinical presentation and natural history of radiation-induced brachial plexopathy in 33 women treated for carcinoma of the breast.

Methods: All of the patients were referred to a single consultant neurologist. Details of surgical procedures, radiotherapy, symptoms at presentation and follow-up and neurological findings were recorded. Read More

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http://dx.doi.org/10.1191/0269215502cr470oaDOI Listing
March 2002
5 Reads

Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy.

Radiother Oncol 2001 Mar;58(3):279-86

Radiotherapy Action Group Exposure, 24 Edgeborough Way, Bromley, Kent BR1 2UA, UK.

Background: Radiation-induced brachial plexopathy (RIBP) is an untreatable complication of curative radiotherapy for early breast cancer, characterized by chronic neuropathic pain and limb paralysis. Hyperbaric oxygen (HBO2) therapy is known to promote healing of tissue rendered ischaemic by radiotherapy, but is untested in RIBP.

Methods: Thirty four eligible research volunteers suffering from RIBP were randomized to HBO2 or control group. Read More

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March 2001
8 Reads

Brachial plexus neuropathy following mantle radiotherapy.

Clin Oncol (R Coll Radiol) 1998 ;10(6):399-400

Northern Centre for Cancer Treatment, Newcastle General Hospital, Newcastle upon Tyne, UK.

We report two cases of presumed radiation-induced brachial plexus neuropathy in patients with lymphoma who were treated with standard mantle radiotherapy to a dose of 40 Gy in 20 fractions. Radiation-induced brachial plexopathy has not previously been reported following mantle irradiation at this dose. Both patients received chemotherapy in relapse. Read More

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March 1999
5 Reads

Occupational therapy intervention with radiation-induced brachial plexopathy.

Authors:
J Cooper

Eur J Cancer Care (Engl) 1998 Jun;7(2):88-92

Royal Marsden NHS Trust, London, UK.

Occupational therapy intervention minimizes disability and facilitates optimum functional independence. The range of dysfunction experienced by patients with radiation-induced brachial plexopathy includes physical, psychological, emotional and social difficulties. The occupational therapist works as part of the multiprofessional team to use a client-centred, problem-solving approach to address the problems and enable the patient to adapt to the altered body image and disabilities. Read More

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June 1998
6 Reads

Radiation-induced brachial plexopathy: MR imaging.

Skeletal Radiol 1997 May;26(5):284-8

Department of Radiology, University Hospital Utrecht, The Netherlands.

Objective: To describe the MR imaging appearance of radiation-induced brachial plexopathy.

Design: MR imaging was performed in two patients with the clinical diagnosis of radiation-induced brachial plexopathy and in one with surgically proven radiation fibrosis of the brachial plexus.

Patients: Three patients who had had radiation therapy to the axilla and supraclavicular region (two with breast carcinoma and one with Hodgkin's lymphoma) presented with symptoms in the arm and hand. Read More

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May 1997
5 Reads

Electrophysiological findings in patients who received radiation therapy over the brachial plexus: a magnetic stimulation study.

Electroencephalogr Clin Neurophysiol 1996 Dec;101(6):483-90

Department of Neurology, Istanbul University, Istanbul Faculty of Medicine, Turkey.

Clinical and electrophysiological findings of 47 asymptomatic females who received radiation therapy (RT) over their brachial plexus region are presented and compared with 8 radiation-induced brachial plexopathy (RBP) and 4 neoplastic brachial plexopathy (NBP) patients. In the asymptomatic group, abnormal findings were more frequent in patients whose post-RT period was longer than 1 year. Flexor carpi radialis H reflex was delayed or absent in 19 patients (52%) in this subgroup of asymptomatic cases, as compared to only 2 (18%) of the patients with post-RT periods of less than 1 year. Read More

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December 1996
11 Reads

Radiation-induced brachial plexopathy: MR and clinical findings.

AJNR Am J Neuroradiol 1996 Nov-Dec;17(10):1932-6

Department of Radiology, University of Miami School of Medicine, FL 33136, USA.

A 54-year-old man had a slowly progressive bilateral brachial plexopathy 17 months after surgery and radiation therapy for a stage IV supraglottic carcinoma. MR imaging at presentation showed a symmetric pattern of parascalene and interscalene hyperintense signal on T2-weighted images and after contrast enhancement. Although hyperintense signal has been more often associated with recurrent tumor than with delayed radiation injury or fibrosis, the location and pattern of the signal abnormalities suggested a diagnosis of radiation-induced plexopathy. Read More

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February 1997
6 Reads

Results of DREZ coagulations for pain related to plexus lesions, spinal cord injuries and postherpetic neuralgia.

Acta Neurochir (Wien) 1996 ;138(4):364-9

Department of Neurosurgery, University of Ulm, Günzburg, Federal Republic of Germany.

The results of 58 dorsal root entry zone (DREZ) thermocoagulation procedures in 51 patients are reported. The postoperative analgesic effect was judged by the patients as being good (more than 75% pain reduction), fair (25-75% pain reduction) or poor (less than 25% pain reduction). Of the 14 patients who underwent surgery for pain due to cervical root avulsion, 10 (77%) had permanently good (8) or fair (2) pain relief after a mean follow up period of 76 months, another 2 (15%) experienced recurrence to the preoperative level (initially 1 good, 1 fair) after more than 2 and 4 years, respectively. Read More

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November 1996
13 Reads

Fasciculation-myokymic activity and prolonged nerve conduction block. A physiopathological relationship in radiation-induced brachial plexopathy.

Authors:
A Esteban A Traba

Electroencephalogr Clin Neurophysiol 1993 Dec;89(6):382-91

Department of Clinical Neurophysiology, Hospital General Gregorio Marañón, Madrid, Spain.

Fourteen radiation-induced brachial plexus neuropathies in 12 patients suffering from cancer were studied. Neurophysiological evaluation showed a diffuse neurogenic lesion with muscular denervation signs associated with motor and sensory nerve conduction impairment of axonal type in the distal segments of the arm. Somatosensory evoked potentials were frequently abnormal, with absence of N9 in 9 out of the 10 extremities explored. Read More

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December 1993
8 Reads

Radiation-induced brachial plexopathy: neurological follow-up in 161 recurrence-free breast cancer patients.

Int J Radiat Oncol Biol Phys 1993 Apr;26(1):43-9

Department of Neurology, Odense University Hospital, Denmark.

Purpose: The purpose was to assess the incidence and clinical manifestations of radiation-induced brachial plexopathy in breast cancer patients, treated according to the Danish Breast Cancer Cooperative Group protocols.

Methods And Materials: One hundred and sixty-one recurrence-free breast cancer patients were examined for radiation-induced brachial plexopathy after a median follow-up period of 50 months (13-99 months). After total mastectomy and axillary node sampling, high-risk patients were randomized to adjuvant therapy. Read More

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April 1993
15 Reads

Dorsal root entry zone lesions in the treatment of pain related to radiation-induced brachial plexopathy.

J Spinal Disord 1993 Feb;6(1):44-7

Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland 21205.

Radiation-induced brachial plexopathy (RBP) is a rare (1-2% of irradiated patients) but serious disorder associated with supramaximal irradiation of the brachial plexus. Nerve compression by radiation-induced fibrosis in the absence of tumor recurrence is the hypothesized mechanism of RBP. It appears as severe pain in up to 20% of cases. Read More

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February 1993
10 Reads

Radiation-induced brachial plexopathy: clinical and electromyographical (EMG) considerations in 13 cases.

Electromyogr Clin Neurophysiol 1990 Aug-Sep;30(5):277-82

Neurological Department, University of Padua, Italy.

The purpose of this study was to determine the clinical and electromyographical characteristics of the initial picture, and the subsequent course of the radiation-induced brachial plexopathy. The AA. studied 13 females affected by infiltrating carcinoma of the breast, who underwent a radical mastectomy with removal of the axillary cavity, followed by radiotherapy (total dose was 50 Gy per cycle). Read More

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December 1990
7 Reads

Natural history of radiation-induced brachial plexopathy compared with surgically treated patients.

Authors:
H E Killer K Hess

J Neurol 1990 Jul;237(4):247-50

Department of Neurology, Kantonspital Aarau, Switzerland.

Twelve patients who developed radiation-induced brachial plexopathy (RIBP) after receiving radiation therapy for breast carcinoma (7 patients) or Hodgkin's lymphoma (5 patients) were followed for 12 or more years, with a mean follow-up time of 20 years. Tingling and numbness of the fingers as well as weakness of the hand or arm were the most prominent presenting symptoms of RIBP. Whereas pain in most patients evolved only later in the course, it became a predominant feature in only 2. Read More

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July 1990
5 Reads

Clinical and electrodiagnostic findings in breast cancer patients with radiation-induced brachial plexus neuropathy.

Acta Neurol Scand 1990 Feb;81(2):153-8

Department of Neurology and Clinical Neurophysiology, Odense University Hospital, Denmark.

The clinical and neurophysiological characteristics of radiation-induced brachial plexopathy (RBP) were assessed in 79 breast cancer patients without signs of recurrent disease at least 60 months after radiotherapy (RT). Clinically, 35% (95% confidence limits: 25-47%) had RBP. Fifty percent (31-69%) had affection of the entire plexus, 18% (7-36%) of the upper trunk only, and 4% (1-18%) of the lower trunk. Read More

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February 1990
10 Reads

Radiation-induced brachial plexus neuropathy in breast cancer patients.

Acta Oncol 1990 ;29(7):885-90

Department of Neurology, Odense University Hospital, Denmark.

The incidence and latency period of radiation-induced brachial plexopathy (RBP) were assessed in 79 breast cancer patients by a neurological follow-up examination at least 60 months (range 67-130 months) after the primary treatment. All patients were treated primarily with simple mastectomy, axillary nodal sampling and radiotherapy (RT). Postoperatively, pre- and postmenopausal patients were randomly allocated chemotherapy or antiestrogen treatment. Read More

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February 1991
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Distinction between neoplastic and radiation-induced brachial plexopathy, with emphasis on the role of EMG.

Neurology 1989 Apr;39(4):502-6

Department of Neurology, Mayo Clinic Foundation, Rochester, MN 55905.

The results of clinical, radiologic, and electrophysiologic studies are retrospectively reviewed for 55 patients with neoplastic and 35 patients with radiation-induced brachial plexopathy. The presence or absence of pain as the presenting symptom, temporal profile of the illness, presence of a discrete mass on CT of the plexus, and presence of myokymic discharges on EMG contributed significantly to the prediction of the underlying cause of the brachial plexopathy. The distribution of weakness and the results of nerve conduction studies were of no help in distinguishing neoplastic from radiation-induced brachial plexopathy. Read More

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April 1989
8 Reads

The H-reflex of the flexor carpi radialis muscle; a study in controls and radiation-induced brachial plexus lesions.

J Neurol Neurosurg Psychiatry 1984 Oct;47(10):1098-101

H-reflexes of the flexor carpi radialis muscle were studied in 52 controls and 25 cancer patients with radiation-induced brachial plexopathy. It was found that H-reflex conduction velocity (H-RCV) decreased with increasing age. This was not true for H-reflex latency (H-RL) and inter-latency times. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1028040PMC
October 1984
8 Reads

[Postradiotherapy brachial plexitis: the experience of the Institut Gustave-Roussy].

Bull Cancer 1983 ;70(2):77-83

Twenty-five cases of presumed radiation-induced brachial plexopathy were identified out of a population treated at the Institut Gustave-Roussy, in 3 different ways, during the period 1967-1980. The incidence of this complication is given for each group, and the radiation dosage and natural history is described, with results of neurolysis when it was possible. The absence of successful treatment methods makes prevention of this complication crucial. Read More

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September 1983
4 Reads
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