54 results match your criteria Radiation-Induced Brachial Plexopathy


Radiation-Induced Brachial Plexopathy in Patients With Breast Cancer Treated With Comprehensive Adjuvant Radiation Therapy.

Adv Radiat Oncol 2021 Jan-Feb;6(1):100602. Epub 2020 Oct 27.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

Purpose: Our purpose was to describe the risk of radiation-induced brachial plexopathy (RIBP) in patients with breast cancer who received comprehensive adjuvant radiation therapy (RT).

Methods And Materials: Records for 498 patients who received comprehensive adjuvant RT (treatment of any residual breast tissue, the underlying chest wall, and regional nodes) between 2004 and 2012 were retrospectively reviewed. All patients were treated with conventional 3 to 5 field technique (CRT) until 2008, after which intensity modulated RT (IMRT) was introduced. Read More

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October 2020

Treatment of radiation-induced brachial plexopathy with omentoplasty.

Autops Case Rep 2020 Sep 2;10(3):e2020202. Epub 2020 Sep 2.

Universidade de São Paulo (USP), Faculdade de Medicina, Hospital das Clínicas, Instituto de Psiquiatria, Peripheral Nerves Group, São Paulo, SP, Brasil.

Radiation-induced brachial plexus neuropathy (RIBPN) is a rare and delayed non-traumatic injury to the brachial plexus, which occurs following radiation therapy to the chest wall, neck, and/or axilla in previously treated patients with cancer. The incidence of RIBPN is more common in patients treated for carcinoma of the breast and Hodgkin lymphoma. With the improvement in radiation techniques, the incidence of injury to the brachial plexus following radiotherapy has dramatically reduced. Read More

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September 2020

Pulsed Radiofrequency Ablation: An Alternative Treatment Modality for Radiation-Induced Brachial Plexopathy.

Pain Med 2021 03;22(3):749-753

Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Radiation therapy is used as a form of treatment for various neoplastic diseases. There are many potential adverse effects of this therapy, including radiation-induced neurotoxicity. Radiation-induced brachial plexopathy (RIBP) may occur due to the fibrosis of neural and perineural soft tissues, leading to ischemic damage of the axons and Schwann cells. Read More

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Teaching Video NeuroImages: Choreoathetosis Due to Radiation-Induced Brachial Plexopathy.

Neurology 2021 03 14;96(10):e1489-e1490. Epub 2020 Sep 14.

From the Department of Neurology, Yokohama City Minato Red Cross Hospital, Japan.

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Delayed onset radiation-induced brachial plexopathy.

Breast J 2020 10 14;26(10):2075-2076. Epub 2020 Jun 14.

Department of Medical Oncology, Cork University Hospital, Co Cork, Ireland.

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October 2020

Neurological and Dexterity Assessments in a Woman with Radiation-Induced Brachial Plexopathy After Breast Cancer.

Oncologist 2020 10 23;25(10):e1583-e1585. Epub 2020 Jun 23.

Physical Therapy Department, St. Paul's Hospital, Vancouver, BC, Canada.

The aim of this case report is to inform clinicians about radiation-induced brachial plexopathy, a rare complication that often presents well after treatment with inconsistent symptoms and manifestations. It is often a diagnosis of exclusion when a neoplastic or other cause cannot be identified. Electrodiagnostic testing is particularly useful. Read More

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October 2020

Intense F-Flourodeoxyglucose Uptake in Brachial Plexus of Patients with Brachial Plexopathy.

Mol Imaging Radionucl Ther 2020 Apr;29(2):79-81

Ankara University Faculty of Medicine, Department of Medical Oncology, Ankara, Turkey.

Brachial plexopathy is a significant cause of pain and disability in patients with breast cancer. Major causes of brachial plexopathy in patients with breast cancer are metastatic invasion or radiation damage to the plexus. Differentiation between the two pathologies is important for appropriate treatment planning. Read More

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Hyperbaric oxygen therapy for radiation-induced brachial plexopathy, a case report and literature review.

Rep Pract Oncol Radiother 2020 Jan-Feb;25(1):23-27. Epub 2019 Nov 18.

Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Aim: To report a case of radiation-induced brachial plexopathy (RIBP) with significant radiographic and clinical improvement after a course of hyperbaric oxygen (HBO).

Background: RIBP is a rare complication after radiotherapy to the neck and axilla. There are no standard treatment options, with empirical use pharmacotherapy being predominately used, which has had mixed results. Read More

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November 2019

The radiation dose tolerance of the brachial plexus: A systematic review and meta-analysis.

Clin Transl Radiat Oncol 2019 Sep 14;18:23-31. Epub 2019 Jun 14.

Department of Radiation Oncology, Cancer Centre of Southeastern Ontario, Kingston, ON, Canada.

Purpose: We performed a systematic review and meta-analysis of studies reporting the incidence of radiation induced brachial plexopathy (RIBP) and the associated radiotherapy doses to this structure.

Methods: Databases were queried without language restriction for cohort studies reporting RIBP incidence and associated brachial plexus dose maximum dose (bpDmax). Studies specifying RIBP relative risk (RR) effect size were selected for meta-analysis. Read More

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September 2019

Radiation-induced brachial plexus toxicity after SBRT of apically located lung lesions.

Acta Oncol 2019 Aug 8;58(8):1178-1186. Epub 2019 May 8.

a Department of Oncology and Pathology , Karolinska Institutet , Stockholm , Sweden.

: To evaluate the rate and dose response of brachial plexus toxicity post stereotactic body radiation therapy (SBRT) of apically situated lung lesions. We retrospectively identified all patients with apically located tumors, defined by the epicenter of the tumor being located superiorly to the aortic arch, and treated with SBRT between 2008 and 2013. Patients with a shorter follow-up than 6 months were excluded. Read More

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Role of surgery in radiation induced brachial plexus neuropathy.

Neurol India 2019 Jan-Feb;67(Supplement):S53-S54

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

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December 2019

Radiation-induced brachial plexus neuropathy: A review.

Neurol India 2019 Jan-Feb;67(Supplement):S47-S52

Department of Neurosurgery, P. D. Hinduja Hospital, Mumbai, Maharashtra, India.

Radiation-induced brachial plexus neuropathy (RIBPN) is an uncommon problem. It is a delayed nontraumatic brachial plexus neuropathy following radiation treatment for carcinomas in the region of neck, axilla, and chest wall. The incidence is more commonly reported following radiation treatment for carcinoma of breast. Read More

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December 2019

Microneurosurgical treatment options in peripheral nerve compression syndromes after chemotherapy and radiation treatment.

J Surg Oncol 2018 Oct 27;118(5):793-799. Epub 2018 Sep 27.

The Institute for Advanced Reconstruction at The Plastic Surgery Center, Shrewsbury, New Jersey.

Chemotherapy-induced peripheral neuropathy and radiation-induced brachial plexopathy are extremely debilitating conditions which can occur after treatment of malignancy. Unfortunately, the diagnosis can be elusive, and this dilemma is further compounded by the lack of efficacious therapeutics to prevent the onset of neurotoxicity before initiating chemotherapy or radiation or to treat these sequelae after treatment. However, microsurgical nerve decompression can provide these patients with a viable option to treat this complication. Read More

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October 2018

Early transient radiation-induced brachial plexopathy in locally advanced head and neck cancer.

Contemp Oncol (Pozn) 2016 16;20(1):67-72. Epub 2016 Mar 16.

Department of Radiation Oncology, Eskisehir Osmangazi University School of Medicine, Turkey.

Aim Of The Study: Early transient brachial plexopathy following radiotherapy (RT) in patients with head and neck cancer may be underreported and associated with a dose-response. Our purpose was to determine the incidence of early transient radiation-ınduced brachial plexopathy (RIBP) in patients receiving primary RT (± chemotherapy) for locally advanced head and neck cancer (HNC).

Material And Methods: Twenty-seven locally advanced HNC patients who have no finding of brachial plexopathy at the diagnosis were evaluated 3 times by a specifically developed 13-item questionnaire for determining early transient RIBP. Read More

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Clinical Utility of (18)F-FDG PET/CT in brachial plexopathy secondary to metastatic breast cancer.

Indian J Nucl Med 2016 Apr-Jun;31(2):123-7

Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.

Role of fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in breast cancer is rapidly evolving. Brachial plexopathy is a rare clinical entity in follow-up of operated breast cancer patients, who presents with disease recurrence in the axilla. Conventionally, magnetic resonance imaging is the imaging modality of choice for diagnostic evaluation in these cases and only few case reports/short studies have explored the utility of PET/CT in this clinical indication. Read More

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Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study.

Oncotarget 2016 Apr;7(14):18887-95

Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Radiation-induced brachial plexopathy (RIBP) is one of the late complications in nasopharyngeal carcinoma (NPC) patients who received radiotherapy. We conducted a retrospective study to investigate its clinical characteristics and risk factors.Thirty-onepatients with RIBP after radiotherapy for NPC were enrolled. Read More

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Brachial plexus dose tolerance in head and neck cancer patients treated with sequential intensity modulated radiation therapy.

Radiat Oncol 2015 Apr 18;10:94. Epub 2015 Apr 18.

Department of Radiation Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, 251 East Huron, LC-178, Chicago, IL, 60611, USA.

Purpose: We aimed to study the radiation induced brachial plexopathy in patients with head and neck squamous cell carcinoma (HNSCC) treated with Sequential Intensity Modulated Radiation Therapy (S-IMRT).

Methods And Materials: This IRB approved study included 68 patients with HNSCC treated consecutively. Detailed dose volume histogram data was generated for ipsilateral and contralateral brachial plexus (BP) volumes receiving a specified dose (Vds) i. Read More

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Dosimetric analysis of the brachial plexus among patients with breast cancer treated with post-mastectomy radiotherapy to the ipsilateral supraclavicular area: report of 3 cases of radiation-induced brachial plexus neuropathy.

Radiat Oncol 2014 Dec 12;9:292. Epub 2014 Dec 12.

Department of Radiation Oncology, Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.

Background: The purpose of this study was to evaluate the brachial plexus (BP) dose of postmastectomy radiotherapy (PMRT) to the ipsilateral supraclavicular (ISCL) area, and report the characteristics of radiation-induced brachial plexus neuropathy (RIBPN).

Methods: The BP dose of 31 patients who received adjuvant PMRT to the ISCL area and chest wall using three-dimensional conformal radiotherapy (3DCRT) and the records of 3 patients with RIBPN were retrospectively analyzed based on the standardized Radiation Therapy Oncology Group-endorsed guidelines. The total dose to the ISCL area and chest wall was 50 Gy in 25 fractions. Read More

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December 2014

Free functioning muscle transfer in radiation-induced brachial plexopathy: case report.

J Hand Surg Am 2014 Oct 22;39(10):1967-70. Epub 2014 Aug 22.

Department of Orthopedics, Ogori Daiichi General Hospital, Yamaguchi, Japan.

Radiation-induced brachial plexopathy is a delayed complication of radiation treatment for tumors involving the neck and chest area and is progressive. A 56-year-old woman presented to us with loss of elbow flexion and weak wrist and finger extension 15 years after she received external beam radiation to the left chest, axilla, and supraclavicular region for treatment of breast cancer. She was managed with a gracilis free muscle transfer for elbow flexion and hand prehension. Read More

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October 2014

External evaluation of the Radiation Therapy Oncology Group brachial plexus contouring protocol: several issues identified.

J Med Imaging Radiat Oncol 2014 9;58(3):360-8. Epub 2014 Apr 9.

Alan Walker Cancer Centre, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Introduction: The aims of the study were to evaluate interobserver variability in contouring the brachial plexus (BP) using the Radiation Therapy Oncology Group (RTOG)-approved protocol and to analyse BP dosimetries.

Methods: Seven outliners independently contoured the BPs of 15 consecutive patients. Interobserver variability was reviewed qualitatively (visually by using planning axial computed-tomography images and anteroposterior digitally reconstructed radiographs) and quantitatively (by volumetric and statistical analyses). Read More

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Whole-Field Sequential Intensity-Modulated Radiotherapy for Local-Regional Advanced Head-and-Neck Squamous Cell Carcinoma.

Am J Clin Oncol 2015 Dec;38(6):588-94

Departments of *Radiation Oncology ‡Medicine, Division of Hematology/Oncology §Otolaryngology, Head and Neck Surgery ∥Preventive Medicine, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL †Department of Clinical Oncology, Alexandria University, Alexandria, Egypt.

Purpose: There is little published data on the technique and results of whole-field (WF) sequential intensity-modulated radiotherapy (S-IMRT) for patients with head-and-neck squamous cell carcinoma (HNSCC). We report the treatment outcomes, adverse events (AEs), and dosimetric parameters in local-regional advanced (LRA) HNSCC patients treated with the WF S-IMRT technique.

Methods: The IRB approved this retrospective study. Read More

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December 2015

Radiation-induced neuropathy in cancer survivors.

Radiother Oncol 2012 Dec;105(3):273-82

Oncologie-Radiothérapie, Hôpital saint Louis, APHP, Paris, France.

Radiation-induced peripheral neuropathy is a chronic handicap, frightening because progressive and usually irreversible, usually appearing several years after radiotherapy. Its occurrence is rare but increasing with improved long-term cancer survival. The pathophysiological mechanisms are not yet fully understood. Read More

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December 2012

Managing the consequences of cancer treatment and the English National Cancer Survivorship Initiative.

Authors:
E J Maher

Acta Oncol 2013 Feb 13;52(2):225-32. Epub 2012 Dec 13.

Mount Vernon Cancer Centre, Northwood, Middlesex, UK.

Background: In 2007 the English National Cancer Survivorship initiative was launched as a partnership between a national charity, Macmillan Cancer Support, the English Department of Health (DH) and the quality improvement agency NHS Improvement. The initiative involved a number of work streams, one of which was to improve the detection and management of the Consequences of adult cancer Treatment (COT).

Material And Methods: The adult COT group took evidence from a range of stakeholders and published a vision and work programme focused on awareness raising, linking self- administered questionnaires to routine activity data collection and testing new models of care with a particular focus on pelvic cancers. Read More

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February 2013

[Radiation-induced neuropathies: collateral damage of improved cancer prognosis].

Rev Neurol (Paris) 2012 Dec 27;168(12):939-50. Epub 2012 Jun 27.

Département des maladies du système nerveux, hôpital Pitié-Salpêtrière, groupe hospitalier Pitié-Salpêtrière, 47 boulevard de l'Hôpital, Paris, France.

Introduction: Because of the improvement of cancer prognosis, long-term damages of treatments become a medical and public health problem. Among the iatrogenic complications, neurological impairment is crucial to consider since motor disability and pain have a considerable impact on quality of life of long cancer survivors. However, radiation-induced neuropathies have not been the focus of great attention. Read More

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December 2012

Brachial plexopathy in apical non-small cell lung cancer treated with definitive radiation: dosimetric analysis and clinical implications.

Int J Radiat Oncol Biol Phys 2013 Jan 1;85(1):175-81. Epub 2012 Jun 1.

Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Purpose: Data are limited on the clinical significance of brachial plexopathy in patients with apical non-small cell lung cancers (NSCLC) treated with definitive radiation therapy. We report the rates of radiation-induced brachial plexopathy (RIBP) and tumor-related brachial plexopathy (TRBP) and associated dosimetric parameters in apical NSCLC patients.

Methods And Materials: Charts of NSCLC patients with primary upper lobe or superiorly located nodal disease who received ≥50 Gy of definitive conventionally fractionated radiation or chemoradiation were retrospectively reviewed for evidence of brachial plexopathy and categorized as RIBP, TRBP, or trauma-related. Read More

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January 2013

Dose constraints to prevent radiation-induced brachial plexopathy in patients treated for lung cancer.

Int J Radiat Oncol Biol Phys 2012 Mar;82(3):e391-8

Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

Purpose: As the recommended radiation dose for non-small-cell lung cancer (NSCLC) increases, meeting dose constraints for critical structures like the brachial plexus becomes increasingly challenging, particularly for tumors in the superior sulcus. In this retrospective analysis, we compared dose-volume histogram information with the incidence of plexopathy to establish the maximum dose tolerated by the brachial plexus.

Methods And Materials: We identified 90 patients with NSCLC treated with definitive chemoradiation from March 2007 through September 2010, who had received >55 Gy to the brachial plexus. Read More

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Brachial plexopathy after chemoradiotherapy for head and neck squamous cell carcinoma.

Strahlenther Onkol 2010 Sep 30;186(9):517-20. Epub 2010 Aug 30.

Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium.

Purpose: To evaluate late brachial plexopathy after primary chemoradiotherapy for locally advanced head and neck squamous cell carcinoma.

Patients And Methods: Consecutive 43 disease-free patients were evaluated by a specifically developed 26-item questionnaire. Retrospectively, the brachial plexus was delineated and the dose-volume histograms were calculated. Read More

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September 2010

Brachial neuropathy 22 years after radiation therapy for fibrosarcoma: a case report.

Cases J 2009 Sep 15;2:6838. Epub 2009 Sep 15.

Department of Plastic and Reconstructive Surgery, Soft Tissue Tumour Reference Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum Buerkle-de-la Camp Platz 1, 44789 Bochum Germany.

This case report presents a 56-year-old man with right upper limb weakness which arose 22 years after initial local radiation treatment for a grade III fibrosarcoma. Nerve conduction studies revealed impairment of all three major upper limb nerves compared with the left, with particular impairment of the median and ulnar nerves in the most fibrotic area that had been irradiated. In addition, the patient received multiple courses of chemotherapy. Read More

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September 2009

Nerve transfer for elbow flexion in radiation-induced brachial plexopathy: a case report.

Hand (N Y) 2009 Jun 9;4(2):123-8. Epub 2008 Oct 9.

Division of Plastic & Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St. Louis, MO 63110, USA.

Radiation-induced brachial plexopathy is an uncommon but devastating late complication seen in patients receiving radiation therapy to the chest wall and axilla. Treatment options are unfortunately limited. We report a case of a 59-year-old woman treated with radiation therapy for breast cancer 12 years earlier, who presented with loss of elbow flexion and marked shoulder weakness. Read More

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[Radiation myelopathy and plexopathy].

Brain Nerve 2008 Feb;60(2):115-21

Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan.

Radiation myelopathy (RM) is a relatively rare disorder characterized by white matter lesions of the spinal cord resulting from irradiation. It is divided into two forms by the latent periods: transient RM and delayed RM. The delayed RM develops usually non-transverse myelopathy symptoms such as dissociated sensory disturbance, unilateral leg weakness, and gait disturbance with asymmetric steps. Read More

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February 2008