6,742 results match your criteria Radiation Therapy in Gynecology


Modern radiotherapy in cancer treatment during pregnancy.

Crit Rev Oncol Hematol 2019 Apr 11;136:13-19. Epub 2019 Feb 11.

Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy; University of Brescia, Italy.

Breast cancer, gynecological malignancies and lymphomas are the most frequently diagnosed tumors in pregnant women. The feasibility of radiotherapy during pregnancy remains a subject of debate and clinicians continue to hesitate on this approach, trying to avoid radiotherapy in most cases. Since the 1990s, several technological advances, including intensity modulated and image guided radiation delivery, have been implemented in radiation oncology to improve the radiation treatment in terms of effectiveness and tolerability. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428193003
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http://dx.doi.org/10.1016/j.critrevonc.2019.02.002DOI Listing
April 2019
1 Read

Outcomes and prognostic factors for patients with cervical esophageal cancer undergoing definitive radiotherapy or chemoradiotherapy.

Bosn J Basic Med Sci 2019 Mar 11. Epub 2019 Mar 11.

Department of Radiotherapy, Inner Mongolia Cancer Hospital, The Affiliated People's Hospital of Inner Mongolia Medical University, Hohhot; Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China; Research Group for Reproductive Medicine and IVF-Laboratory, Department of Obstetrics and Genecology, University of Cologne, Cologne, Germany.

Cervical esophageal cancer (CEC) is uncommon, accounting for less than 5% of all esophageal cancers. The management of CEC is controversial. This study investigated treatment outcomes and prognostic factors of survival in CEC patients undergoing definitive radiotherapy or concurrent chemoradiotherapy (CCRT). Read More

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http://dx.doi.org/10.17305/bjbms.2019.3873DOI Listing

Predictors of Lymphoceles in Women Who Underwent Laparotomic Retroperitoneal Lymph Node Dissection for Early Gynecologic Cancer: A Retrospective Cohort Study.

Int J Environ Res Public Health 2019 Mar 15;16(6). Epub 2019 Mar 15.

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei 220, Taiwan.

Lymphoceles could represent a detrimental complication after retroperitoneal lymph node dissection. Our aim was to elucidate predictors of lymphoceles. Between 2011 and 2017, medical records of consecutive women who underwent laparotomic retroperitoneal lymph node dissection for FIGO stage I or II gynecologic cancer were reviewed. Read More

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http://dx.doi.org/10.3390/ijerph16060936DOI Listing

Fifteen-year survival of invasive epithelial ovarian cancer in women with BRCA1/2 mutations - the National Israeli Study of Ovarian Cancer.

Gynecol Oncol 2019 Mar 11. Epub 2019 Mar 11.

Cancer & Radiation Epidemiology Unit, Gertner Institute for Epidemiology & Health Policy Research, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: Compare 5, 10 and 15 year survival in invasive epithelial ovarian cancer, between patients with and without BRCA1/2 germ line mutation in a nonselective group of patients diagnosed during 1994-99.

Methods: The analysis was based on 779 Jewish patients: 229 carriers to the Ashkenazi Jewish founder mutations in BRCA1 (185delAG; 5382insC) and BRCA2 (6174delT); and 550 non-carriers. Clinical characteristics were abstracted from the patients' medical records and vital status was updated through the National Population Registry up to 11/2015. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.022DOI Listing

Comparison of oncologic outcomes of unanticipated cervical carcinoma in women undergoing inadvertent simple hysterectomy and those undergoing surgical treatment after preoperative diagnosis.

Gynecol Oncol 2019 Mar 11. Epub 2019 Mar 11.

Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objectives: To determine the proportion of women with undiagnosed cervical carcinoma before simple hysterectomy and its causes and to compare the oncologic outcomes of women diagnosed and treated with standard therapy to those undergoing inadvertent simple hysterectomy with subsequent treatment.

Methods: Medical records were reviewed for patients with cervical carcinoma who underwent hysterectomy between 1 January 2004 and 31 December 2014. Demographic data, chemotherapeutic agents, and response rates were analyzed using descriptive statistics. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.025DOI Listing

Ovarian function after ovarian transposition and additional pelvic radiotherapy: A systematic review.

Eur J Surg Oncol 2019 Mar 5. Epub 2019 Mar 5.

Leiden University Medical Center, Department of Gynecology, Leiden, South Holland, the Netherlands.

Objective: To investigate the ovarian survival (OS) after ovarian transposition (OT) and pelvic radiation.

Design: Systematic review. Electronic databases were searched to identify studies on OT prior to external beam radiation therapy (EBRT, to the pelvic). Read More

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http://dx.doi.org/10.1016/j.ejso.2019.02.017DOI Listing

Efficacy and Toxicity of IMRT-Based Simultaneous Integrated Boost for the Definitive Management of Positive Lymph Nodes in Patients with Cervical Cancer.

J Cancer 2019 29;10(5):1103-1109. Epub 2019 Jan 29.

Department of Radiation Oncology, Xijing Hospital. The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.

: The optimal radiotherapy regimen for treating metastatic lymphadenopathy in patients with locally advanced cervical cancer remains controversial. This study aimed to investigate the clinical outcomes, as well as associated toxicities, of intensity-modulated radiotherapy (IMRT) with a simultaneous integrated boost (SIB) for pelvic and para-aortic lymph nodes (LNs). : Between 2011 and 2015, 74 patients with 2014 International Federation of Gynecology and Obstetrics stage IIB-IVB cervical cancer exhibiting pelvic or para-aortic LN involvement were examined. Read More

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http://dx.doi.org/10.7150/jca.29301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400667PMC
January 2019
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2.639 Impact Factor

Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability.

Neoplasia 2019 Mar 6;21(4):363-375. Epub 2019 Mar 6.

Department of Gynecology, Goethe-University, Frankfurt am Main; German Cancer Consortium (DKTK) / German Cancer Research Center, partner site, Frankfurt a. M.. Electronic address:

Paclitaxel is a frontline drug for the treatment of epithelial ovarian cancer (EOC). However, following paclitaxel-platinum based chemotherapy, tumor recurrence occurs in most ovarian cancer patients. Chromosomal instability (CIN) is a hallmark of cancer and represents genetic variation fueling tumor adaptation to cytotoxic effects of anticancer drugs. Read More

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http://dx.doi.org/10.1016/j.neo.2019.01.007DOI Listing
March 2019
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Perinatal complications in female survivors of cancer: a systematic review and meta-analysis.

Eur J Cancer 2019 Mar 5;111:126-137. Epub 2019 Mar 5.

MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK. Electronic address:

Background: Observational studies have suggested that perinatal outcomes are worse in offspring of cancer survivors. We conducted a systematic review and meta-analysis to examine the risks of perinatal complications in female cancer survivors diagnosed before the age of 40 years.

Methods: All published articles on pregnancy, perinatal or congenital risks in female cancer survivors were screened for eligibility. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.104DOI Listing
March 2019
3 Reads

Health-related Quality of Life in Women with Cervical Cancer.

Rev Bras Ginecol Obstet 2019 Mar 7. Epub 2019 Mar 7.

Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil.

Objective:  To analyze the factors associated with health-related quality of life (HRQoL) in women with cervical cancer (CC) in a single center in Rio de Janeiro, state of Rio de Janeiro, Brazil.

Methods:  A cross-sectional study in women with a diagnosis of CC followed-up in the gynecology outpatient clinic of the Hospital do Câncer II (HCII, in the Portuguese acronym) of the Instituto Nacional de Câncer (INCA, in the Portuguese acronym). The data were collected from March to August 2015. Read More

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http://dx.doi.org/10.1055/s-0039-1683355DOI Listing
March 2019
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Short term outcomes of helical tomotherapy during concurrent chemoradiotherapy for advanced cervical cancer.

Mol Clin Oncol 2019 Mar 23;10(3):382-386. Epub 2019 Jan 23.

Department of Obstetrics and Gynecology, Wakayama Medical University, School of Medicine, Wakayama, Wakayama 641-0012, Japan.

The aim of the present study was to clarify the feasibility and efficacy of helical tomotherapy during concurrent chemoradiotherapy for treating cervical cancer. The medical records of 13 patients who underwent oncurrent chemoradiotherapy using helical tomotherapy for cervical cancer at Wakayama Medical University Hospital between 2013 and 2015 were retrospectively reviewed. A total of 15 patients who underwent oncurrent chemoradiotherapy using conventional radiotherapy (CRT) between 2008 and 2013 at our institution were also examined for comparison. Read More

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http://dx.doi.org/10.3892/mco.2019.1806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388508PMC
March 2019
2 Reads

Frequency and risk factors for arm lymphedema after multimodal breast-conserving treatment of nodal positive breast Cancer - a long-term observation.

Radiat Oncol 2019 Mar 7;14(1):39. Epub 2019 Mar 7.

Department of Radiation Oncology, Hannover Medical School (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

Background: Arm-lymphedema is a major complication after breast cancer. Recent studies demonstrate the validity of predicting Breast Cancer Related Lymphedema (BCRL) by self-reports. We aimed to investigate the rate of BCRL and its risk factors in the long-term using self-reported symptoms. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1243-yDOI Listing
March 2019
3 Reads

Lack of Survival Benefit of Para-Aortic Lymphadenectomy in Advanced Cervical Cancer.

Gynecol Obstet Invest 2019 Mar 7:1-5. Epub 2019 Mar 7.

Gynecologic Oncology Unit. La Paz University Hospital, Madrid, Spain.

Introduction: The presence of positive para-aortic lymph nodes in advanced cervical cancer remains the most important prognostic factor for survival and also defines the treatment. Our aim was to define the influence of staging para-aortic lymphadenectomy in patients' survival.

Material And Methods: The medical records of 74 patients with advanced cervical cancer (FIGO IIB-IVA) were reviewed. Read More

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http://dx.doi.org/10.1159/000497350DOI Listing
March 2019
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Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy.

J Control Release 2019 Mar 4;300:154-160. Epub 2019 Mar 4.

Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address:

Solid cancers are able to escape immune surveillance and are resistant to current treatment in immunotherapy. Recent evidence indicates the critical role of the stimulator of interferon genes (STING) pathway in antitumor immunity. STING-targeted activation is extensively investigated as a new strategy for cancer therapy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.036DOI Listing

Radiotherapy for isolated recurrent epithelial ovarian cancer: A single institutional experience.

J Obstet Gynaecol Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

Aim: To evaluate the efficacy and toxicity of external beam radiotherapy (RT) for isolated recurrent epithelial ovarian cancer (EOC).

Methods: Twenty-four isolated recurrent EOC patients treated with RT at Osaka University Hospital between January 2000 and January 2017 were included in the current study. Data regarding the primary or recurrent diseases, follow-up findings, and efficacy or toxicities of RT were collected and retrospectively analyzed. Read More

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http://dx.doi.org/10.1111/jog.13947DOI Listing
March 2019
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Cancer During Pregnancy: The Oncologist Overview.

World J Oncol 2019 Feb 26;10(1):28-34. Epub 2019 Feb 26.

Division of Hematology and Oncology, University of Tennessee Health Science Center/West Cancer Center, Memphis, TN, USA.

Although a rare and challenging condition, cancer during pregnancy should promptly be identified and treated. Not only standards of care guidelines for the underlying disease are taken into account, but also fetal safety might be weighted for clinical decisions. Frequent lack of experience and knowledge about this condition could lead to late diagnosis, imprecise management, suboptimal treatment and fetal and maternal harm. Read More

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http://dx.doi.org/10.14740/wjon1177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396773PMC
February 2019

Location of recurrences in high-risk stage Iendometrial cancer patients not given postoperative radiotherapy: A Danish gynecological cancer group study.

Int J Gynecol Cancer 2019 Mar 4;29(3):497-504. Epub 2019 Jan 4.

Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark.

Objectives: To study recurrence rates in Danish high-risk stage I endometrial cancers not given radiotherapy in accordance with the decision of the Danish Gynecological Cancer Group.

Methods: This prospective national cohort study includes all 4707 endometrial carcinomas diagnosed from 2005 to 2012. Of these, 623 patients had grade 3 endometroid adenocarcinoma with >50% myometrial invasion or serous/clear/undifferentiated carcinoma (with any depth of invasion). Read More

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http://dx.doi.org/10.1136/ijgc-2018-000056DOI Listing
March 2019
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Perivascular epitheliod cell tumors: Study of three gynecological cases.

Med Clin (Barc) 2019 Feb 28. Epub 2019 Feb 28.

Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clínic - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Antecedents: Perivascular epitheliod cell tumor (PEComa) is a rare mesenchymal tumor. They are rare in the field of gynecology, which makes them difficult to consider as a possible diagnostic. We aim to contribute with our experience to ease clinical practice to others gynecologists. Read More

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http://dx.doi.org/10.1016/j.medcli.2019.01.009DOI Listing
February 2019

Significance of BRCA1 expression in breast and ovarian cancer patients with brain metastasis - A multicentre study.

Adv Med Sci 2019 Feb 26;64(2):235-240. Epub 2019 Feb 26.

Department of Gynecology and Gynecologic Oncology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Cerebral metastases develop in 10-30% of patients with breast cancer (BC) and in around 3.3 to 4% of patients with ovarian cancer (OC). The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), stromal cell-derived factor 1 (SDF1) and its receptor C-X-C chemokine receptor type 4 (CXCR4), breast cancer metastasis suppressor 1 (BRMS1), astrocyte elevated gene 1 (AEG1), depending on the status of BRCA1 protein, in patients suffering from OC and BC with brain metastases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18961126183015
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http://dx.doi.org/10.1016/j.advms.2018.12.007DOI Listing
February 2019
3 Reads

Adenocarcinoma of the uterine cervix: Pathologic features, treatment options, clinical outcome and prognostic variables.

Crit Rev Oncol Hematol 2019 Mar 19;135:103-114. Epub 2019 Jan 19.

Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy.

Adenocarcinoma accounts for 10-25% of all cervical cancers, and its relative and absolute rate has raised over the past decades. Most, but not all the authors, reported that adenocarcinoma has a greater propensity to lymph node, ovarian and distant metastases and a worse prognosis compared with squamous cell carcinoma. However, whether histologic type is an independent prognostic factor is still a debated issue. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.01.006DOI Listing
March 2019
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Colony‑stimulating factor 1 receptor inhibition blocks macrophage infiltration and endometrial cancer cell proliferation.

Mol Med Rep 2019 Feb 18. Epub 2019 Feb 18.

Department of Gynecology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.

Tumor‑associated macrophages (TAMs) promote the progression of endometrial cancer (EC), but the mechanism of TAM in EC cell proliferation remains unclear. It was found that colony stimulating factor (CSF)‑1 and CSF‑1 receptor (CSF‑1R) were highly expressed in EC tissues of patients and two EC cell lines (ECC‑1 and HEC‑1A). Using wound‑healing and chemotactic migration assays to evaluate the role of EC cells in the induction of macrophage migration, it was found that the supernatant of EC cells promoted macrophage cell line (U937) migration; however, the migration capacity of U937 weakened when CSF‑1R was blocked. Read More

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http://dx.doi.org/10.3892/mmr.2019.9963DOI Listing
February 2019
2 Reads

Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions.

Cells 2019 Feb 26;8(3). Epub 2019 Feb 26.

Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.

In the era of personalized medicine, the introduction of translational studies in clinical trials has substantially increased their costs, but provides the possibility of improving the productivity of trials with a better selection of recruited patients. With the overall goal of creating a roadmap to improve translational design for future gynecological cancer trials and of defining translational goals, a main discussion was held during a brainstorming day of the Gynecologic Cancer InterGroup (GCIG) Translational Research Committee and overall conclusions are here reported. A particular emphasis was dedicated to the new frontier of the immunoprofiling of gynecological cancers. Read More

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http://dx.doi.org/10.3390/cells8030200DOI Listing
February 2019
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Major clinical research advances in gynecologic cancer in 2018.

J Gynecol Oncol 2019 Mar;30(2):e18

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Nineteen topics were selected as major clinical research advances in gynecologic oncology in 2018. For cervical cancer, the importance of human papillomavirus (HPV) testing alone as primary cervical cancer screening method and negative survival impact of minimally invasive surgery in early-stage cervical cancer were addressed. For ovarian cancer, cost-effectiveness of genetic testing to prevent cancer, use of analgesics and oral pill to reduce cancer risk, efficacy of secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, update in the use of poly (ADP-ribose) polymerase inhibitor, and efficacy of anti-angiogenic targeted treatments, including bevacizumab and tyrosine kinase inhibitors, were reviewed. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393635PMC
March 2019
1 Read

Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes.

Tumour Biol 2019 Jan;41(1):1010428318815413

3 Department of Oncology and Radiotherapy and Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a major regulator of the oxidative stress response and it is negatively regulated by Kelch-like ECH-associated protein 1 (Keap1). The Keap1-Nrf2 axis has a fundamental role in carcinogenesis. In previous studies, the widely used diabetes drug metformin has appeared to have a critical role in the regulation of Nrf2 function. Read More

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http://dx.doi.org/10.1177/1010428318815413DOI Listing
January 2019
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[Preliminary study of sequential multi-modality adjuvant chemotherapy and radiation for advanced endometrial cancer].

Zhonghua Fu Chan Ke Za Zhi 2019 Feb;54(2):103-109

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

To evaluate the clinical outcomes and feasibility of multi-modality adjuvant chemotherapy and radiation, which was conducted as postoperative chemotherapy, radiation, and consolidation chemotherapy (CRC) mode for the treatment of advanced endometrial cancer. A retrospective analysis of 124 patients with International Federation of Gynecology and Obstetrics (FIGO) stages Ⅲ and Ⅳ endometrial cancer from Jan. 2004 to Oct. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.02.006DOI Listing
February 2019
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Neoadjuvant Chemoradiotherapy Followed by Extrafascial Hysterectomy in Locally Advanced Type II Endometrial Cancer Clinically Extending to Cervix.

Pract Radiat Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Radiation Oncology, Magee Women's Hospital of UPMC, Pittsburgh, PA, USA; Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address:

Objective: The role of neoadjuvant chemoradiotherapy in locally-advanced type II endometrial cancer is controversial. We thus aimed to present our experience with the hypothesis that neoadjuvant chemoradiotherapy is associated with similarly high rates of downstaging and locoregional control for type II endometrial cancer as for type I endometrial cancer.

Methods: Thirty-four patients with type II endometrial cancer with clinical evidence of cervical ± parametrium involvement treated with neoadjuvant external beam radiotherapy (45-50. Read More

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http://dx.doi.org/10.1016/j.prro.2019.02.007DOI Listing
February 2019
2 Reads

Validation of a Nomogram Predicting Non-Sentinel Lymph Node Metastases among Patients with Breast Cancer after Primary Systemic Therapy - a transSENTINA Substudy.

Breast Care (Basel) 2018 Dec 6;13(6):440-446. Epub 2018 Nov 6.

Interdisciplinary Breast Centre, Department of Gynecology and Obstetrics, Klinikum Esslingen, Esslingen, Germany.

Background: Prediction of non-sentinel lymph node (SLN) status after primary systemic therapy (PST) may allow tailored axillary staging. The aim of this analysis was to compare established nomograms from i) the primary operative (n = 6) and ii) the neoadjuvant (n = 1) setting with an optimized nomogram to predict non-SLN status in patients after PST.

Methods: 181 patients converting from cN1 prior to PST to ycN0 but found to have a histologically positive SLN in the SENTINA trial were analyzed. Read More

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http://dx.doi.org/10.1159/000489565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381911PMC
December 2018
1 Read

Recommendations for assessing ovarian health and fertility potential in survivors of childhood cancer.

Maturitas 2019 Apr 25;122:57-59. Epub 2019 Jan 25.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Colorado Denver, 12631 East 17th Avenue, Mail Stop B198-3, Academic Office 1, United States.

Most children diagnosed with cancer survive for many years after treatment. However, the fertility potential of these patients may suffer due to their oncologic therapies. Certain chemotherapies and radiation are more likely to be detrimental to gonadal function, and put patients at risk of acute or premature ovarian failure. Read More

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http://dx.doi.org/10.1016/j.maturitas.2019.01.009DOI Listing
April 2019
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Impact of estrogen monotherapy on survival in women with stage III-IV non-small cell lung cancer.

Lung Cancer 2019 Mar 24;129:8-15. Epub 2018 Dec 24.

Department of Radiation Oncology, Columbia University Irving Medical Center, 622 W 168th St, New York, NY, 10032, United States; Herbert Irving Comprehensive Cancer Center, 1130 St Nicholas Ave, New York, NY, 10032, United States. Electronic address:

Objectives: Women with lung cancer have better survival than men. The reasons are unknown, but estrogen is hypothesized to improve survival. Our objective was to examine the association between estrogen monotherapy and cancer-specific and overall survival in elderly women with non-small cell lung cancer (NSCLC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183072
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http://dx.doi.org/10.1016/j.lungcan.2018.12.021DOI Listing
March 2019
4 Reads

Single-center long-term results from the randomized phase-3 TARGIT-A trial comparing intraoperative and whole-breast radiation therapy for early breast cancer.

Strahlenther Onkol 2019 Feb 22. Epub 2019 Feb 22.

Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Purpose: Partial breast irradiation using intraoperative radiotherapy (IORT) after breast-conserving surgery could be sufficient for a selected group of breast cancer patients. We report the results of a cohort of patients from a single center treated as part of the randomized phase-3 TARGIT-A trial.

Methods: Patients (≥50 years) with cT1 cN0 cM0 and invasive ductal histology on biopsy were randomized between IORT with 20 Gy (arm-A) or postoperative whole-breast RT (WBRT) up to 56 Gy in 2 Gy fractions (arm-B). Read More

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http://dx.doi.org/10.1007/s00066-019-01438-5DOI Listing
February 2019
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Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Mar 19;20(3):339-351. Epub 2019 Feb 19.

Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria; Department of Gynaecology and Obstetrics, Medical University of Vienna, Vienna, Austria.

Background: In postmenopausal women with hormone receptor-positive, early-stage breast cancer, treatment with adjuvant aromatase inhibitors is the standard of care, but it increases risk for osteoporosis and fractures. Results from the ABCSG-18 trial showed that use of denosumab as an adjuvant to aromatase inhibitor therapy significantly reduced clinical fractures. Disease-free survival outcomes from ABCSG-18 have not yet been reported. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30862-3DOI Listing
March 2019
2 Reads

β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Gynecology, Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan, China. Electronic address:

Hepatoblastoma (HB), the most common pediatric primary liver neoplasm, shows nuclear localization of β-catenin and yes-associated protein 1 (YAP1) in almost 80% of the cases. Coexpression of constitutively active S127A-YAP1 and ΔN90 deletion-mutant β-catenin (YAP1-ΔN90-β-catenin) causes HB in mice. Because heterogeneity in downstream signaling is being identified owing to mutational differences even in the β-catenin gene alone, we investigated if co-expression of point mutants of β-catenin (S33Y or S45Y) with S127A-YAP1 led to similar tumors as YAP1-ΔN90-β-catenin. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.02.002DOI Listing
February 2019
2 Reads

Definitive radiotherapy for recurrent vulvar carcinoma after primary surgery: a two-institutional Italian experience.

Tumori 2019 Feb 21:300891618811279. Epub 2019 Feb 21.

1 Department of Translational Medicine, Division of Radiation Oncology, University of Pisa, Italy.

Objective:: To assess the clinical outcome of patients treated with radiotherapy (RT) for recurrent squamous cell carcinoma of the vulva after primary surgery.

Methods:: Fifty-six patients developed recurrent disease after surgery, consisting of deep total vulvectomy with inguino-femoral lymphadenectomy in 44 (78.6%) and deep partial vulvectomy with inguino-femoral lymphadenectomy in 12 (21. Read More

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http://dx.doi.org/10.1177/0300891618811279DOI Listing
February 2019
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Retroperitoneal fibrosis after chemo-radiotherapy for cervical cancer: A case report.

J Obstet Gynaecol Res 2019 Feb 20. Epub 2019 Feb 20.

Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Retroperitoneal fibrosis (RPF) is a rare disease characterized by proliferation of fibro-inflammatory tissue in the retroperitoneum. Multiple studies have reported on the idiopathic cases of the disease, but reports of RPF secondary to irradiation are very limited. Herein, we report the case of a 47-year-old woman who complained of lower abdominal pain 14 months after chemo-radiotherapy for cervical cancer. Read More

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http://dx.doi.org/10.1111/jog.13898DOI Listing
February 2019
1 Read

Analysis of Treg cell population in patients with breast cancer with respect to progesterone receptor status.

Contemp Oncol (Pozn) 2018 31;22(4):236-239. Epub 2018 Dec 31.

Department of Oncology, Radiotherapy, and Gynecologic Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Breast cancer is the most frequently diagnosed type of cancer in women worldwide. Both the development and progression of breast cancer are related to tumour evasion of the immune system through a process called cancer immune-editing, in which regulatory lymphocytes play an important role. The infiltration of Treg cells in patients with breast cancer has been proposed as an independent unfavourable prognostic factor. Read More

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http://dx.doi.org/10.5114/wo.2018.80038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377420PMC
December 2018

Exploring the added value of hospital-registry data for showing local service outcomes: cancers of the ovary, fallopian tube and peritoneum.

BMJ Open 2019 Feb 19;9(2):e024036. Epub 2019 Feb 19.

Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objectives: To explore the added value of hospital-registry data on invasive epithelial ovarian, tubal and peritoneal cancers.

Design: Historic cohort analyses.

Methods: Unadjusted and adjusted regression. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02403
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http://dx.doi.org/10.1136/bmjopen-2018-024036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367964PMC
February 2019
4 Reads

Squamous Carcinoma of the Neovagina after Male-to-Female Reconstruction Surgery: A Case Report and Review of the Literature.

Case Rep Obstet Gynecol 2019 16;2019:4820396. Epub 2019 Jan 16.

Department of Gynaecology, University Hospital Zurich, Zurich, Switzerland.

Squamous cell carcinoma (SCC) of the neovagina after genital reconstruction surgery is a rare occurrence with only very few cases published up to the present. We report a case of a 43-year-old transgender woman who developed neovaginal SCC 23 years after vaginoplasty. The patient tested positive for high-risk human papillomavirus (HPV). Read More

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http://dx.doi.org/10.1155/2019/4820396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354136PMC
January 2019
1 Read

Cisplatin and radiation therapy in HIV-positive women with locally advanced cervical cancer in sub-Saharan Africa: A phase II study of the AIDS malignancy consortium.

Gynecol Oncol 2019 Feb 15. Epub 2019 Feb 15.

AIDS Malignancy Consortium, New York, NY, United States of America. Electronic address:

Purpose: To determine the feasibility, safety, and tolerability of concomitant chemoradiotherapy administered at standard doses in HIV-infected women with locally-advanced cervical cancer (LACC) receiving antiretroviral therapy (ART).

Patients And Methods: Eligible participants had HIV infection and untreated, histologically-confirmed, invasive carcinoma of the uterine cervix, FIGO stages IB2, IIA (if tumor >4 cm), IIB, IIIA, IIIB, or IVA and met standard eligibility criteria. Subjects were prescribed 41. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.01.023DOI Listing
February 2019
1 Read

Quality of reporting of outcomes in trials of therapeutic interventions for pressure ulcers in adults: a protocol for a systematic survey.

BMJ Open 2019 Feb 15;9(2):e024633. Epub 2019 Feb 15.

Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.

Pressure ulcers (PUs) have a high incidence, especially in hospital units. Randomised clinical trials (RCTs) of therapeutic interventions for PU should include a clear description of the outcomes and results to enhance transparency and replicability.

Objectives: The primary objective of this study is to assess the completeness of the descriptions of the outcomes of therapeutic interventions in RCTs in adult patients with PU. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024633DOI Listing
February 2019
3 Reads

Localized high grade endometrial stromal sarcoma and localized undifferentiated uterine sarcoma: a retrospective series of the French Sarcoma Group.

Int J Gynecol Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Oncology, CHU Timone, AP-HM, Marseille, France.

Objective: High grade endometrial stromal sarcoma and undifferentiated uterine sarcomas are associated with a very poor prognosis. Although large surgical resection is the standard of care, the optimal adjuvant strategy remains unclear.

Methods: A retrospective analysis of patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas (stages I-III) treated in 10 French Sarcoma Group centers was conducted. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000064DOI Listing
February 2019
3 Reads

Assessment of dose to functional sub-structures in the lower urinary tract in locally advanced cervical cancer radiotherapy.

Phys Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.

Purpose: To provide an analysis of dose distribution in sub-structures that could be responsible for urinary toxicity after Image-Guided Adaptive BrachyTherapy (IGABT) in Locally Advanced Cervical Cancer (LACC).

Methods: 105 LACC patients treated with radiochemotherapy and IGABT were selected. Sub-structures (bladder wall, trigone, bladder neck, urethra) were contoured on IGABT-planning MRIs. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.01.017DOI Listing
February 2019
2 Reads

Risk factors for pelvic and distant recurrence in locally advanced cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:6-12. Epub 2019 Feb 6.

Medical Oncology Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil. Electronic address:

Objective: Despite the benefits of concomitant radiotherapy and cisplatin for locally advanced cervical cancer, recurrence rates remain high. New treatment strategies such as consolidation chemotherapy and different concomitant chemotherapy combinations have been tested in recent years. Identification of the best candidates for each treatment strategy could optimize results. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.028DOI Listing
February 2019
1 Read

Clear Cell Carcinoma of the Abdominal Wall as a Rare Complication of General Obstetric and Gynecologic Surgeries: 15 Years of Experience at a Large Academic Institution.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology; National Taiwan University Hospital, Taipei 100, Taiwan.

The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. Read More

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http://dx.doi.org/10.3390/ijerph16040552DOI Listing
February 2019
1 Read

Influence of 18F-FDG-PET/CT on staging of cervical cancer.

Nuklearmedizin 2019 Feb 15;58(1):17-22. Epub 2019 Feb 15.

Chair and Department of Electroradiology, Poznan University of Medical Science.

Aim: Cervical cancer is one of the most common cancers of the female reproductive system. The aim of the study was to assess the usefulness of the F-FDG-PET/CT study in staging of cervical cancer, with focus on the primary tumor parameters.

Material & Methods: 105 patients (mean age 56 ± 11y) with newly diagnosed cervical cancer underwent PET/CT examination which was performed 60 min after IV injection of F-FDG with a mean activity of 364 ± 75MBq. Read More

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http://dx.doi.org/10.1055/a-0809-4577DOI Listing
February 2019
1 Read

Conventional radiotherapy and intensity-modulated radiotherapy in carcinoma vulva: An experience from a tertiary medical center of India.

South Asian J Cancer 2019 Jan-Mar;8(1):41-43

Department of Radiotherapy and Oncology, Postgraduate Medical Education and Research, Chandigarh, India.

Context: Vulvar cancer is one of the uncommon gynecological malignancies. Multimodality treatment with surgery, radiotherapy, and chemotherapy are required for treatment of the disease.

Aims: The aim of the study was to evaluate clinical outcome in patients of carcinoma vulva, treated at our institution. Read More

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http://dx.doi.org/10.4103/sajc.sajc_66_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348779PMC
February 2019

International radical trachelectomy assessment: IRTA study.

Int J Gynecol Cancer 2019 Mar 13;29(3):635-638. Epub 2019 Feb 13.

Oncological surgery, Clinica Astorga, Envigado, Colombia.

Background: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy.

Primary Objective: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000273DOI Listing
March 2019
3 Reads

Potential of survivin for treatment of gynaecological tumour diseases.

Ceska Gynekol 2018 ;83(3):226-231

Objective: The main purpose of this article is to consolidate known facts about survivin, its contribution to inhibition of apoptosis, impact to tumorigenesis of gynaecological types of tumours. and possibilities of inhibition of survivin on molecular-genetic levels.

Design: A review article. Read More

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January 2018
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Electrical stimulation on adverse events caused by chemotherapy in patients with cervical cancer: A protocol for a systematic review of randomized controlled trial.

Medicine (Baltimore) 2019 Feb;98(7):e14609

Department of Gynecology.

Background: This protocol of systematic review aims to investigate the effectiveness of electrical stimulation (ES) on adverse events (AEs) caused by chemotherapy in patients with cervical cancer (CC).

Methods: This systematic review of randomized controlled trials will be identified through searchers of PUBMED, PsycINFO, Scopus, Opengrey, Cochrane Central Register of Controlled Trials, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. All the sources will be searched from the inception to the date of study search ran. Read More

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http://dx.doi.org/10.1097/MD.0000000000014609DOI Listing
February 2019
1 Read

High tumor cell vimentin expression indicates prolonged survival in patients with ovarian malignant tumors.

Ginekol Pol 2019 ;90(1):11-19

Department of Tumour Pathology and Pathomorphology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland.

Objectives: The main aims of the study were to investigate the expression of vimentin and its correlation with the overall survival (OS) of patients with malignant ovarian tumors, and the correlation between vimentin expression and tumor stroma characteristics.

Material And Methods: The study focused on 94 malignant ovarian tumors that had been collected from women who were treated in the Department of Gynecology and Oncology of the Lukaszczyk Oncological Center, Bydgoszcz, Poland. Vimentin expression was assessed in both the cancer cells (expression intensity and quantitative analysis) and the tumor stroma (expression intensity). Read More

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http://dx.doi.org/10.5603/GP.2019.0003DOI Listing
January 2019
3 Reads

Genitourinary Fistula: A Curse to Neglected Pregnancy.

Mymensingh Med J 2019 Jan;28(1):206-213

Dr Nasrin Akhter, Associate Professor, Department of Obstetrics & Gynecology, Dhaka Medical College, Dhaka, Bangladesh.

Genitourinary fistula is a psychophysiosocial distress that results in prolonged labour. Gradually, it has become a public health issue globally with advancing of its incidence day by day. A handsome number of mothers are also suffering in Bangladesh from genitourinary fistula. Read More

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January 2019
1 Read