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N Z Med J 2022 Jun 10;135(1556):127-131. Epub 2022 Jun 10.

Department of Otolaryngology-Head and Neck Surgery, Waikato Hospital, New Zealand.

Papillary thyroid cancer is the most common type of well-differentiated thyroid cancer. It is associated with a survival rate greater than 95% with appropriate treatment, particularly in younger patients. We present the unique case of a 25-year-old male with severe Autistic spectrum disorder (ASD) with a right level V neck mass of several months. Read More

Gulf J Oncolog 2022 May;1(39):63-69

Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt.

Purpose: This study presents the experience of the National Cancer Institute, Cairo University, in diagnosis and management of ACC of the head and neck.

Methods: This is a retrospective review of 57 patients with ACC managed during the period from January 2011 to January 2016. Data about the characteristics and management of the disease were recorded. Read More

Head Neck 2022 Jul 18;44(7):1725-1736. Epub 2022 Apr 18.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Data describing features and management of oropharyngeal neuroendocrine carcinomas (NEC) remain sparse. A systematic review was performed. Patients were stratified by treatment modality and examined for disease progression and survival outcomes. Read More

Rep Pract Oncol Radiother 2022 22;27(1):23-31. Epub 2022 Mar 22.

Department of Radiation Oncology, ASST Spedali Civili and Brescia University, Italy.

30-60% of cancer patients develop lung metastases, mostly from primary tumors in the colon-rectum, lung, head and neck area, breast and kidney. Nowadays, stereotactic radiotherapy (SRT ) is considered the ideal modality for treating pulmonary metastases. When lung metastases are suspected, complete disease staging includes a total body computed tomography (CT ) and/or positron emission tomography-computed tomography (PET -CT ) scan. Read More

BMJ Case Rep 2022 Apr 8;15(4). Epub 2022 Apr 8.

Department of Obstetrics and Gynaecology, Division of Gynaecology, Taipei Veterans General Hospital, Taipei, Taiwan

Primary vaginal neuroendocrine tumours are extremely rare but aggressive. We report a case of primary poorly differentiated vaginal carcinoma with focal neuroendocrine differentiation. The clinical stage was cT3N1M0, FIGO stage III. Read More

Int J Radiat Oncol Biol Phys 2022 Apr 5. Epub 2022 Apr 5.

Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048. Electronic address:

Background: Better understanding of the relationship between spread of head and neck squamous cell carcinoma (HNSCC) to regional lymph nodes (LN) and the frequency and manner of treatment failure should help design better treatment intensification strategies. In this study, we evaluate the relationship between recurrence patterns, mortality, and number of pathologically positive (+) LN in HNSCC in three prospective randomized controlled trials.

Methods: Secondary analysis of 947 HNSCC patients enrolled on XXX (N=410), XXX (N=203), and XXX (N=334) undergoing surgery and post-operative radiation +/- systemic therapy. Read More

J Radiosurg SBRT 2022 ;8(1):11-19

University of Pittsburgh Hillman Cancer Center, Department of Radiation Oncology, Pittsburgh, PA, USA.

Background: There is limited data on clinical outcomes following SBRT for patients with metastatic head and neck squamous cell carcinoma (mHNC).

Method: An international SBRT registry was utilized to identify patients. LC and OS were evaluated with the Kaplan-Meier method and a Cox-proportional hazards model for multivariate analysis (MVA) to assess potential prognostic factors. Read More

J Cancer Res Ther 2022 Jan-Mar;18(1):119-123

Registrar Department of Radiotherapy, GMC Jammu, Jammu and Kashmir, India.

Background: Cancers in the head-and-neck region are the sixth most common cancers worldwide with an increasing incidence in developing countries.

Methods: This study was carried out in the department of ENT and head-and-neck surgery in collaboration with the department of radiotherapy for a period of 1 year extending from May 01, 2014, to April 30, 2015. A total of 48 cases of metastatic secondary nodes were included in the study. Read More

Eur Arch Otorhinolaryngol 2022 Mar 31. Epub 2022 Mar 31.

Department of Otorhinolaryngology-Head and Neck Surgery, Rouen University Hospital, 37 boulevard Gambetta, 76000, Rouen, France.

Objectives: Main: To describe 1-year overall survival (OS) after primary or salvage management of head and neck squamous cell carcinoma (HNSCC) invading the common or internal carotid artery (CCA/ICA). Secondary: To assess disease control rate, treatment morbidity, and radio-anatomopathologic correlation.

Methods: Retrospective study of 67 patients, treated between 1999 and 2020 for N3bM0 HNSCC invading the CCA/ICA as identified by CT-scan. Read More

Front Endocrinol (Lausanne) 2021 9;12:752176. Epub 2022 Mar 9.

Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.

Background: The overall survival (OS) of pancreatic cancer (PC) patients with bone metastasis (BM) is extremely low, and it is pretty hard to treat bone metastasis. However, there are currently no effective nomograms to predict the diagnosis and prognosis of pancreatic cancer with bone metastasis (PCBM). Therefore, it is of great significance to establish effective predictive models to guide clinical practice. Read More

Front Oncol 2022 1;12:800920. Epub 2022 Mar 1.

Department of Radiation Oncology, German Oncology Center, Limassol, Cyprus.

The optimal management of intrahepatic malignancies involves a multidisciplinary approach. Although surgical resection has been considered the only curative approach, the use of several minimally invasive ablative techniques has dramatically increased the last two decades, mainly due to the fact that they provide similar oncological results with significantly decreased morbidity. Among these modalities, interstitial liver brachytherapy, probably the most flexible liver ablative method, with excellent clinical data on its safety and effectiveness, is frequently not even mentioned as an option in the current peer reviewed literature and guidelines. Read More

Oral Oncol 2022 04 1;127:105798. Epub 2022 Mar 1.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

Objectives: Increasing use of transoral robotic surgery (TORS) is likely to impact outcomes for HPV+ oropharyngeal squamous cell carcinomas (OPSCCs). We aimed to describe oncologic outcomes for a large HPV+ OPSCC cohort after TORS and develop a risk prediction model for recurrence under this treatment paradigm.

Materials And Methods: 634 HPV+ OPSCC patients receiving TORS-based therapy at a single institution were reviewed retrospectively to describe survival across the entire cohort and for patients suffering recurrence. Read More

J Med Case Rep 2022 Feb 25;16(1):92. Epub 2022 Feb 25.

Department of Dental Research, Federico Henriquez y Carvajal University, Santo Domingo, 10106, Dominican Republic.

Background: Paragangliomas are rare vascular neuroendocrine tumors that develop in the extra-adrenal paraganglion tissue. They occur most commonly at the carotid bifurcation, where they are known as carotid body tumors. Most paragangliomas are benign, locally aggressive, infiltrative tumors. Read More

Comput Intell Neurosci 2022 8;2022:6132481. Epub 2022 Feb 8.

Department of Otolaryngology, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia.

Hypopharyngeal carcinoma is usually present at late stages, necessitating an aggressive line of management consisting of surgical procedures, chemotherapy, and radiation therapy, depending on the case. Practitioners tend to support total laryngectomies or total esophagostomies for most cases of hypopharyngeal carcinoma. The extensive procedures needed will most probably require, depending on the residual defect, a follow-up reconstructive procedure that might require utilizing flaps. Read More

Curr Treat Options Oncol 2022 Jan 15;23(1):43-53. Epub 2022 Feb 15.

Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

Opinion Statement: Malignant tumors of the external auditory canal (EAC) are rare tumors in the head and neck. Delayed diagnosis is not uncommon because the symptoms of early tumors are nonspecific. Various surgical and oncological treatment modalities have been reported. Read More

Am J Otolaryngol 2022 Mar-Apr;43(2):103374. Epub 2022 Feb 2.

Department of Otolaryngology - Head and Neck Surgery, University of Tennessee - Memphis, Memphis, TN, USA.

Background: Metastases to the parotid nodal basin in patients with high-risk cutaneous squamous cell carcinoma (HRcSCC) impact disease specific survival (DSS) and overall survival (OS).

Methods: A writing group convened by the Salivary Section of the American Head and Neck Society (AHNS) developed contemporary, evidence-based recommendations regarding management of the parotid nodal basin in HRcSCC based on available literature, expert consultation, and collective experience. The statements and recommendations were then submitted and approved by the AHNS Salivary Committee. Read More

Med J Malaysia 2022 01;77(1):53-59

Universitas Indonesia, Faculty of Medicine, Department of Otorhinolaryngology Head and Neck Surgery, Indonesia.

Introduction: Treatment of head and neck cancer patients amidst the COVID-19 pandemic is challenging, whereas prolonged treatment initiation in head and neck squamous cell carcinoma may increase mortality and likelihood of recurrence. Special attention is needed to ensure safe and appropriate care of these patients. This article aims to review and discuss existing research on treatment prioritization and risk stratification of head and neck cancer patients during the pandemic. Read More

Surg Case Rep 2022 Jan 27;8(1):21. Epub 2022 Jan 27.

Kachi Memorial Hospital, 456 Fujimi, Minami-ohshimizu-cho, Toyohashi, Aichi, 441-8555, Japan.

Background: Few reports exist of the long-term management of recurrent and progressive papillary thyroid carcinoma (PTC) with a tyrosine kinase inhibitor for over 5 years.

Case Presentation: A 57-year-old woman was referred to a psychiatric hospital for the treatment of schizophrenia. The patient had been diagnosed with a PTC at the age of 40 and subsequently underwent a left thyroid lobectomy. Read More

Gan To Kagaku Ryoho 2021 Dec;48(13):1721-1724

Division of Oral and Maxillofacial Surgery, National Hospital Organization Hamada Medical Center.

We report a case of functional recovery following incisional cheiloplasty for the management of lower labial edema that developed after bilateral neck dissection with preservation of the one-side internal jugular vein and postoperative chemoradiotherapy. An 81-year-old woman underwent partial maxillectomy for the treatment of maxillary gingival cancer(squamous cell carcinoma, cT1N0M0, Stage Ⅰ)in April 2013. In July 2013, she underwent bilateral neck dissection(right, modified; left, radical)for bilateral cervical lymph node recurrence with an extra-nodal spread and received postoperative chemoradiotherapy( CDDP 75 mg/m2×3 course and total radiotherapy dosage of 66 Gy). Read More

Cancer Manag Res 2022 6;14:89-101. Epub 2022 Jan 6.

Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.

After primary treatment for prostate cancer with either radical prostatectomy or radiotherapy, a significant proportion of patients are at risk of developing metastases. In recent years, a deeper understanding of the underlying biology together with improved imaging techniques and the advent of new therapeutic options including metastases-directed therapies and new drugs have revolutionized the management of low-burden metastatic disease, also known as oligometastatic state. The purpose of this narrative review is to report the recent developments in the management of hormone-sensitive oligometastatic prostate cancer patients. Read More

World J Nucl Med 2021 Oct-Dec;20(4):361-368. Epub 2021 Nov 1.

Department of Endocrinology, Amrita Institute of Medical Sciences and Research Center, Kochi, Kerala, India.

Management of differentiated thyroid carcinoma (DTC) patients with thyroglobulin (Tg) elevation and negative iodine scintigraphy (TENIS) and negative neck ultrasound scan causes considerable diagnostic and therapeutic dilemma, especially in resource-poor settings. The aim of this study was to evaluate clinicopathological features and outcome of TENIS patients with negative neck US attending a thyroid cancer clinic in India. From a DTC database of 722 containing 193 TENIS patients, subjects with negative neck US and negative Tg antibody (TgAb) were selected retrospectively and analyzed using appropriate statistical methods. Read More

Ann Otol Rhinol Laryngol 2022 Jan 6:34894211069459. Epub 2022 Jan 6.

Oregon Health and Science University School of Medicine, Portland, OR, USA.

Objectives: Discussions regarding the specific management and outcomes for laryngeal MEC are limited to very small, single-institution case series. To look further into the diagnosis and management of these uncommon non-squamous cell carcinomas of the larynx, we present 3 recent cases of laryngeal MEC treated at our institution.

Methods: Patients at a tertiary hospital treated for MEC between October 2019 and December 2020 were retrospectively identified. Read More

Head Neck 2022 03 19;44(3):722-734. Epub 2021 Dec 19.

Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham & Women's Hospital, Boston, Massachusetts, USA.

Background: There is limited information on the management and outcomes of oligometastases (OM) in adenoid cystic carcinoma (ACC).

Methods: Retrospective study of 42 patients with metastatic ACC of the head and neck. Imaging studies were analyzed to identify patients with OM (1-5 lesions) at any point during follow-up. Read More

Oral Oncol 2022 01 3;124:105653. Epub 2021 Dec 3.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objective: To explore the effects of elective neck irradiation (ENI) in clinically node-negative (cN0) sinonasal adenoid cystic carcinoma (SNACC).

Materials And Methods: Between January 2000 and December 2016, 60 patients with cN0 sinonasal adenoid cystic carcinoma receiving surgery combined with radiotherapy were analyzed retrospectively, there were 39 received ENI (ENI group) and 21 with no ENI (non-ENI group). Propensity score matching (PSM) was performed to balance clinical factors and match patients. Read More

Ann R Coll Surg Engl 2022 May 29;104(5):e150-e152. Epub 2021 Nov 29.

Lancashire Teaching Hospitals NHS Foundation Trust, UK.

Secondary primary malignancies within the head and neck region are well documented. Within this group, synchronous tumours with an index oral cancer are usually found in the oropharyngeal or laryngeal sites. We present a rare case of an index squamous cell carcinoma in the tongue with a synchronous primary intraosseous squamous cell carcinoma. Read More

Genes (Basel) 2021 11 21;12(11). Epub 2021 Nov 21.

Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.

Management of nasopharyngeal carcinoma (NPC) remains elusive despite new developments and advancement that has been made in the current management approaches. A patient's survival and prognosis remain dismal especially for a late-stage disease. This is highly attribute to the chemoradiation resistance. Read More

J Laryngol Otol 2022 Apr 25;136(4):297-303. Epub 2021 Nov 25.

Head and Neck Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Background: Lateral temporal bone resections are used in the management of locally advanced peri-auricular cutaneous squamous cell carcinomas, but there is still conflicting evidence regarding the staging, surgical and adjuvant treatment decisions.

Methods: A retrospective analysis was performed on all patients who underwent lateral temporal bone resection for cutaneous squamous cell carcinoma between January 2015 and December 2019 at a dedicated tertiary oncology referral centre.

Results: Twenty-nine patients were included, with a median age of 77 years. Read More

Cureus 2021 Oct 13;13(10):e18735. Epub 2021 Oct 13.

Otolaryngology - Head and Neck Surgery, University Hospital Crosshouse, Kilmarnock, GBR.

A 75-year-old lady was referred to the oral and maxillofacial surgery (OMFS) team with a painless swelling in the midline of her forehead. Investigations diagnosed it as a solitary metastasis of thyroid cancer. Follicular thyroid cancers are known to metastasise to bone; however, bony metastasis to the frontal bone of the skull is very rare. Read More

Am J Clin Oncol 2021 12;44(12):624-628

Departments of Radiation Oncology.

Objective: Compared with radical resection alone, perioperative radiation therapy (RT) combined with neurovascular preserving surgery is the standard for the management of virgin soft-tissue sarcomas. Yet, the optimal management of a local recurrence remains unclear. We report outcomes of patients with locally recurrent soft-tissue sarcoma treated with resection and reirradiation at the University of Florida. Read More

Int J Surg Case Rep 2021 Nov 14;88:106506. Epub 2021 Oct 14.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Electronic address:

Introduction: Angiosarcoma is a very rare malignancy, which varies based on the location and organ affected. A clinicopathological form of cutaneous angiosarcoma (CAS) involves the head: scalp, face, and neck. We report a 59-year-old female patient with CAS on the temporoparietal region of the scalp. Read More