Search Our Scientific Publications & Authors

Oral Oncol 2019 Apr 16;91:7-12. Epub 2019 Feb 16.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China. Electronic address:

Objectives: Epstein-Barr virus (EBV)-positive cervical lymph node (CLN) metastasis of unknown primary origin is classified as nasopharyngeal carcinoma (NPC) T0 by the American Joint Committee on Cancer staging manual (8th edition). We aimed to investigate the possible primary sites and patterns of EBV-positive CLN metastases and to provide implications for the management of NPC T0 classification.

Materials And Methods: We retrospectively reviewed 269 patients with newly diagnosed EBV-positive CLN metastatic disease who underwent EBV detection via EBV-encoded RNA in situ hybridization. Read More

J Natl Cancer Inst 2019 Mar 26. Epub 2019 Mar 26.

Clinical Investigative Branch, Cancer Therapy Evaluation Program, National Institute of Health, Bethesda, MD.

Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer with a distinctive regional and racial prevalence. It is associated with Epstein Barr Virus infection and has a high propensity for regional and distant metastases, while at the same time it is very sensitive to radiation and chemotherapy. A common feature of Epstein Barr Virus-positive NPC is the dense infiltration of lymphocytes in the tumor stroma and positive PD-L1 expression in tumor cells, making it an attractive target for immunotherapy, especially immune checkpoint inhibitors. Read More

Radiol Med 2019 Mar 9. Epub 2019 Mar 9.

Radiation Oncology Department, Ospedale Policlinico San Martino, Università di Genova, Genoa, Italy.

Background: This study, promoted by Italian Association of Radiotherapy and Clinical Oncology (AIRO) Head and Neck Group, aimed to assess the current national practice of target volume delineation on a case of neck lymph node metastases from unknown primary evaluating inter-observer variability, in a setting of primary radiotherapy.

Materials And Methods: A case of metastatic neck lymph node from occult primary was proposed to 17 radiation oncologists. A national reference RT center was identified and considered as benchmark. Read More

Br J Neurosurg 2019 Mar 5:1-6. Epub 2019 Mar 5.

a Department of Neurological Surgery, Wexner Medical Center , The Ohio State University College of Medicine , Columbus , OH , USA.

Introduction: Pituitary carcinomas are poorly understood, rare entities. They are distinguished from adenomas not by histopathological features but rather by the presence of metastases.

Objective: We discuss the diagnosis, mechanism of dissemination and pathogenesis based on a review of the literature and illustrated by a singular case. Read More

Semin Radiat Oncol 2019 04;29(2):93-101

Wright Center of Innovation in Biomedical Imaging, Division of Imaging Science, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

The purpose of this article is to present the recent imaging advancements enabled by digital photon counting positron emission tomography detector technology and discuss its potential applications in the clinical management of head and neck cancer (HNC) and nodal metastases. F-fluorodeoxyglucose positron-emission tomography is a clinically useful biomarker for the detection, targeted biopsy, treatment planning, and therapeutic response assessment of HNC. This article highlights the current state of F-fluorodeoxyglucose positron-emission tomography imaging in HNC management as well as the emerging capabilities of the recently introduced digital photon counting positron emission tomography/computed tomography platform for more effective molecular and functional HNC imaging. Read More

Semin Radiat Oncol 2019 04;29(2):171-179

Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA. Electronic address:

The two types of nonmelanoma skin cancer most apt to metastasize to lymph nodes are cutaneous squamous cell carcinoma and Merkel cell carcinoma. The clinical impact of nodal metastases of these cancers is substantial, resulting in intensification of treatment and morbidity and worsened cancer outcomes. Exact best practices are challenging to define as many specific clinical scenarios remain incompletely catalogued, characterized, or studied. Read More

Semin Radiat Oncol 2019 04;29(2):144-149

Department of Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX.

The management of cancers of the head and neck focuses on primary site and regional (neck) disease control. Many patients are treated with surgery as the principal mode of treatment, and surgery often includes an elective or therapeutic neck dissection. Risk factors assessed for recurrence subsequent to neck dissection include nodal size, number, levels, and the presence of extranodal spread. Read More

Eur J Cancer 2019 Apr 28;111:69-81. Epub 2019 Feb 28.

Department of Radiation Therapy, Centre Francois Baclesse, Advanced Resource Center for Hadrontherapy in Europe, Caen, France, Unicaen-Normandie Universite. Electronic address:

Introduction: Patients with cervical lymphadenopathy of unknown primary carcinoma (CUP) usually undergo neck dissection and irradiation. There is an ongoing controversy regarding the extent of nodal and mucosal volumes to be irradiated. We assessed outcomes after bilateral or unilateral nodal irradiation. Read More

Int J Pediatr Otorhinolaryngol 2019 May 10;120:93-99. Epub 2019 Feb 10.

Department of Otolaryngology & Communication Enhancement, Boston Children's Hospital, Boston, MA, 02115, United States; Department of Otolaryngology, Harvard Medical School, Boston, MA, 02115, United States. Electronic address:

Introduction: Mucoepidermoid carcinoma is a rare malignant salivary gland neoplasm in the pediatric population. Few studies have discussed best practice with respect to diagnosis and treatment in children.

Objective: To present our institution's experience with the evaluation and management of pediatric mucoepidermoid carcinoma of the head and neck. Read More

Adv Otorhinolaryngol 2019 12;83:76-89. Epub 2019 Feb 12.

Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands,

The management of hypopharyngeal cancer is challenging because of poor patient survival and the potential effects of treatment on breathing, voice and swallowing. In general, early stage hypopharyngeal cancer can be primarily treated by radiotherapy or conservative transoral or open surgery, whereas advanced stage hypopharyngeal cancer can be treated by non-surgical protocols if the patient has no loss of functions (dysfunctional larynx) and/or cartilage invasion (T4a). Factors to determine individualized patient treatment include resectability, tumour volume, distant metastases, comorbidity, age, patient's preference, functional imaging parameters, response on induction chemotherapy and employing functional imaging parameters performed in the pre-treatment phase and repeated in the early treatment phase when employing a non-surgical treatment strategy. Read More

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Induction chemotherapy (IC) is a treatment option for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN). However, treatment with docetaxel, cisplatin, and 5-FU (TPF) followed by cisplatin and radiotherapy is controversial because of toxicity concerns. The aim of this phase II study was to assess the feasibility of docetaxel, cisplatin, and cetuximab (TPEx) followed by cetuximab and concurrent radiotherapy for LA SCCHN. Read More

Turk Arch Otorhinolaryngol 2018 Dec 26;56(4):210-216. Epub 2018 Oct 26.

Department of Otorhinolaryngology, İstanbul University School of Medicine, İstanbul, Turkey.

Objective: We present 11 patients with distant metastases to the head and neck from an infraclavicularly located primary tumor and discuss the management strategies including the clinical presentation, treatment modalities, and prognosis.

Methods: The retrospective data of the pathology reports and operation notes of 1239 patients who had undergone any kind of oncological surgical intervention between 2005 and 2017 were analyzed. All of the 11 patients included in the study were evaluated in our department's tumor board, and all patients with an operable lesion had undergone surgery. Read More

Rev Esp Med Nucl Imagen Mol 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiation Oncology, University Hospital 12 de Octubre, Madrid, España.

Purpose: The aim is to investigate the use of F-FDG (fluorine-18 fluorodeoxyglucose) PET/CT in head and neck cancer (HNC) staging and its effect on the therapeutic strategy and radiotherapy (RT) planning.

Methods And Materials: One hundred patients with HNC were included. Primary tumor sites: 18% oral cavity, 20% oropharynx, 12% hypopharynx, 11% nasopharynx, 37% larynx, 2% paranasal sinuses. Read More

JAMA Netw Open 2018 Aug 3;1(4):e181390. Epub 2018 Aug 3.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Stereotactic ablative radiotherapy (SABR) is first-line treatment for patients with early-stage non-small cell lung cancer (NSCLC) who cannot undergo surgery. However, up to 1 in 6 such patients will develop isolated local recurrence (iLR) or isolated regional recurrence (iRR). Little is known about outcomes when disease recurs after SABR, or about optimal management strategies for such recurrences. Read More

World J Clin Oncol 2018 Dec;9(8):200-207

Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, United States.

Background: Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical literature.

Case Summary: In this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma. Read More

Int J Pediatr Otorhinolaryngol 2019 Feb 26;117:138-142. Epub 2018 Nov 26.

Georgetown University School of Medicine, 3900 Reservoir Road, Washington D.C., 20007, USA; Department of Otolaryngology-Head & Neck Surgery, MedStar Georgetown University Hospital, 3800 Reservoir Road, Washington D.C., 20007, USA.

Objective: To determine the demographics, treatment modalities, and overall survival of pediatric Ewing sarcoma of the head and neck.

Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results database was used to identify cases of pediatric Ewing sarcoma of the head and neck between 1973 and 2015. Additional variables collected included age, gender, ethnicity, tumor grade, staging, treatment modality, and follow-up time. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13633

Department of Orthodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology.

The management of the node negative neck in patients with tongue cancer remains a complex and controversial issue, especially in those with early stage tumors. Patients with negative cervical lymph nodes generally have a good prognosis. However, in patients without neck dissection, neck recurrences may occur after excision of the primary tumor due to occult cervical metastases. Read More

Global Spine J 2018 Dec 19;8(8):866-871. Epub 2018 Apr 19.

Galway University Hospitals, Galway, Republic of Ireland.

Study Design: Literature review.

Objectives: Metastatic disease affecting the craniovertebral junction (CVJ) only accounts for 0.5% of all spine metastases. Read More

J Stomatol Oral Maxillofac Surg 2019 Apr 1;120(2):160-163. Epub 2018 Nov 1.

Service de stomatologie et chirurgie maxillo-faciale, Cliniques universitaires Saint-Luc, UCL, avenue Hippocrate 10, 1200 Bruxelles, Belgium.

Background: The risk of metastasizing in axillary lymph node is occasional in the head and neck cancers. This pattern of spread is difficult to explain and totally unpredictable even for these lymphophilic cancers.

Observation: A 72-year-old patient benefited, 11 years ago, of surgical oncology care associated with adjuvant radiotherapy for squamous cell carcinoma of the left floor of the mouth (pT4 pN2b M0). Read More

Clin Oncol (R Coll Radiol) 2018 Dec 13;30(12):764-772. Epub 2018 Sep 13.

Head and Neck Unit, Imperial College Healthcare NHS Trust, London, UK; Department of Clinical Oncology, Imperial College Healthcare NHS Trust, London, UK; Department of Surgery and Cancer, Imperial College, London, UK. Electronic address:

Aims: Management of the clinically node-negative (cN0) neck for parotid tumours remains controversial. Options include observation, elective neck dissection (END) or elective nodal irradiation (ENI). We reviewed the evidence for ENI on a background of current practice among UK clinical oncologists. Read More

Oral Oncol 2018 Oct 17;85:29-34. Epub 2018 Aug 17.

Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA 703-389-1895, United States. Electronic address:

Radiologic predictors of response to immune checkpoint blockade (ICPi) in advanced head and neck squamous cell carcinoma (HNSCC) patients could help guide patient selection and management. We analyzed a large institutional cohort of 100 consecutive HNSCC patients treated with ICPi to investigate associations between molecular and radiologic phenotype and assess radiologic predictors of response and survival. Of particular interest was the impact of increased total tumor burden (TB), calculated as the sum of the largest diameter of all measurable lesions according to RECIST 1. Read More

Ann Surg Oncol 2018 Nov 14;25(12):3453-3459. Epub 2018 Sep 14.

Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University, Nashville, TN, USA.

This is the second of a two-part review on adrenocortical carcinoma (ACC) management. While margin-negative resection provides the only potential cure for ACC, recurrence rates remain high. Furthermore, many patients present with locally advanced, unresectable tumors and/or diffuse metastases. Read More

PLoS One 2018 22;13(8):e0202632. Epub 2018 Aug 22.

Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.

Background: The new AJCC staging system (8th edition) incorporates depth of invasion to stage oral cancers. It is a recognized predictor for neck nodal metastasis and local recurrence, the associated risk is not well defined. The aim of this study was to explore the risk of occult neck nodal metastasis and local recurrence in relation to depth in early stage squamous cell carcinoma of oral tongue. Read More

Cureus 2018 Jun 5;10(6):e2738. Epub 2018 Jun 5.

Internal Medicine, Shifa College Of Medicine, Islamabad, PAK.

Thyroid cancer is the most common endocrine cancer in the world, with a rising global incidence over the last three decades. Papillary thyroid cancer (PTC) is the most common type of thyroid neoplasia, accounting for 74%-80% of all cases. Skull metastasis from a differentiated thyroid malignancy is a rare occurrence, while a subsequent dural involvement is even more inimitable. Read More

BMJ Case Rep 2018 Aug 1;2018. Epub 2018 Aug 1.

Department of Surgery, Duke University Hospital, Durham, North Carolina, USA.

Adenoid cystic carcinomas (ACCs) are rare malignant neoplasms of exocrine glands, most commonly found in salivary glands. This report describes a 67-year-old woman with metastatic ACC to the breast, only the third reported case of its kind. The salivary gland ACC was first diagnosed 5 years prior. Read More

BMC Musculoskelet Disord 2018 Jul 11;19(1):213. Epub 2018 Jul 11.

"Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No 2, 300041, Timisoara, Romania.

Background: Deep vein thrombosis is a well-known complication of fracture occurrence, lower limb surgery and periods of prolonged immobilisation. Its incidence can be increased even more in specific cases with metastatic bone disease and adjuvant treatment. There is a small amount of literature that addresses the incidence of DVT by comparing osteosynthesis and arthroplasty as surgical treatments. Read More

Medicine (Baltimore) 2018 Jul;97(28):e11371

Department of Otorhinolaryngology, Head and Neck Surgery.

Rationale: Most cases of lymphoepithelial carcinoma (LEC) occur in the nasopharynx, and LEC in the sinonasal tract is extremely rare; thus, the clinical characteristics of sinonasal LEC are not well known.

Patient Concerns: A 63-year-old Japanese man presented with a three-week history of left cheek pain, nasal obstruction and cheek swelling.

Diagnoses: Enhanced CT and MRI revealed a tumor of the left maxillary sinus that invaded the left orbit and hard palate, with multiple swollen left cervical lymph nodes. Read More

Int J Radiat Oncol Biol Phys 2018 07 18;101(4):935-944. Epub 2018 Apr 18.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Purpose: Acute hospital encounters in patients undergoing curative-intent radiation therapy (RT) have not previously been well characterized. Understanding acute visit patterns among RT patients yields insights for risk assessments and cancer urgent care clinics that could decrease hospitalization rates and reduce health care costs. This study aims to identify patient, disease-site, and treatment characteristics associated with emergency department visits and inpatient admissions in cancer patients treated with definitive RT. Read More

Int Forum Allergy Rhinol 2018 09 23;8(9):1065-1072. Epub 2018 Jun 23.

Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Rangueil-Larrey, Toulouse, France.

Background: Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management.

Methods: A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors. Read More

Pract Radiat Oncol 2018 Nov - Dec;8(6):452-457. Epub 2018 May 16.

Department of Radiation Medicine, Northwell Health, Lake Success, NY; Hofstra Northwell School of Medicine, Hempstead, NY. Electronic address:

Purpose/objective: Radium-223 prolongs survival and decreases symptomatic skeletal events in men with metastatic castrate-resistant prostate cancer and is indicated in patients with painful bone metastases. However, pain responses are rarely reported and often asked about by patients. Further, patients and their physicians are concerned about a lack of pain response portending a poor treatment response and may be inclined to change systemic therapies before completing 6 cycles. Read More

Case Rep Oncol 2018 May-Aug;11(2):289-297. Epub 2018 May 17.

Department of Oncology - ESMO European Society for Medical Oncology - Designated Centre of Integrated Oncology and Palliative Care, Poliambulanza Foundation Hospital, Brescia, Italy.

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, with a high metastatic potential. Epstein-Barr virus (EBV) infection plays a fundamental role, even if it is not well understood. The diagnosis of the disease in its early stage is infrequent. Read More

Indian J Surg Oncol 2018 Jun 20;9(2):187-191. Epub 2018 Apr 20.

Surgical Oncology Division, Regional Cancer Centre, Trivandrum, 695011 India.

Head and neck soft tissue sarcoma (HNSTS) is a rare neoplasm accounting for 1% of all head and neck tumours. Because of rarity and varied biological behaviour among various subtypes, knowledge about these tumours is limited. This study aimed at analysing clinicopathological, recurrence and survival pattern of surgically treated HNSTS. Read More

PLoS One 2018 8;13(6):e0198391. Epub 2018 Jun 8.

Department of Otolaryngology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.

Background: Chemoradiotherapy (CRT) has improved organ preservation or overall survival (OS) of locoregionally advanced head and neck squamous cell cancer (LAHNSCC), but in clinical trials of conventional CRT, increasing CRT intensity has not been shown to improve OS. In the Adjuvant ChemoTherapy with S-1 after curative treatment in patients with Head and Neck Cancer (ACTS-HNC) phase III study, OS of curative locoregional treatments improved more with adjuvant chemotherapy with S-1 (tegafur gimeracil oteracil potassium) than with tegafur/uracil (UFT). ACTS HNC study showed the significant efficacy of S-1 after curative radiotherapy in sub-analysis. Read More

Eur Arch Otorhinolaryngol 2018 Jul 21;275(7):1885-1892. Epub 2018 May 21.

Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek (NKI-AVL), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Purpose: The aggressive behavior of salivary duct carcinoma (SDC) necessitates an aggressive treatment strategy, including surgery and radiotherapy (RT). We evaluated practice patterns and treatment outcomes in patients with SDC treated in our Institute.

Methods: Patients with SDC of the parotid or submandibular gland treated with curative intention in our Institute from 1998 until 2016 were reviewed. Read More

Eur Arch Otorhinolaryngol 2018 Jul 18;275(7):1869-1875. Epub 2018 May 18.

Department of Head and Neck Oncology, Institute Gustave Roussy, Université Paris-Saclay, 114 rue Edouard Vaillant, 94805, Villejuif, France.

Purpose: Retrospective studies have shown that tracheotomy prior to total laryngectomy (TL) is associated with decreased survival. We sought to investigate whether this is due to higher local invasiveness associated with obstructive disease or whether it is the result of tracheotomy itself.

Methods: We reviewed patients with a T4a (AJCC 7th edition) laryngeal squamous-cell carcinoma treated with a primary TL followed by adjuvant radiotherapy between 2001 and 2013. Read More

Strahlenther Onkol 2018 Aug 14;194(8):750-758. Epub 2018 May 14.

Department of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany.

Background: Due to the absence of randomized trials, the optimal management for squamous cell cancer of unknown primary in the head and neck region (SCCHN CUP) remains controversial. Current strategies are based on retrospective studies, clinical experience, and institutional policies.

Methods: An anonymous questionnaire with a total of 24 questions was created and distributed by the use of an online version (Google Forms®, Google, Mountain View, CA, USA) as well as a printout version as equivalent option. Read More

Head Neck 2018 Oct 13;40(10):2295-2303. Epub 2018 May 13.

Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.

Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma.

Methods: We conducted a systematic review and meta-analysis.

Results: Forty-eight studies totaling 118 patients met inclusion criteria. Read More

Cancer Radiother 2018 Sep 3;22(5):438-446. Epub 2018 May 3.

Département de radiothérapie/Archade, centre François-Baclesse, 3, avenue General-Harris, 14000 Caen, France; Université Unicaen, 14000 Caen, France. Electronic address:

The definition of nodal and/or mucosal target volumes for radiation therapy for lymphadenopathies of unknown primary is controversial. Target volumes may include all nodal areas bilaterraly and be pan-mucosal or unilateral, selective, including the sole oropharyngeal mucosa. This review presents current recommendations in light of changes in the TNM classification, Human papillomavirus status and therapeutic advances. Read More

J Craniomaxillofac Surg 2018 Jun 5;46(6):1007-1012. Epub 2018 Apr 5.

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.

Purpose: Lymph node ratio (LNR) essentially improves assessment of prognosis and therapeutic decision making for patients with oral squamous cell carcinoma, as it considers both the number of positive lymph nodes and the number of dissected lymph nodes. Mandibular infiltration by oral squamous cell carcinoma is a vital clinicopathological feature, significantly worsens prognosis. However, to the best of our knowledge, data on the influence of LNR on prognosis for patients with OSCC and mandibular infiltration are not available. Read More

Ann Cardiothorac Surg 2018 Mar;7(2):183-196

Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.

Background: Secondary tracheal tumors arise from mural invasion by primary tumors in adjacent organs, metastatic lymph nodes or blood-born metastasis from distant sites. This systematic review aims to assess the presentation, management options, and clinical outcomes of these uncommon non-tracheal malignancies.

Methods: Electronic searches of the MEDLINE database were performed to identify case series and individual case reports of tracheal invasion by primary non-tracheal tumors or metastatic disease. Read More

J Otolaryngol Head Neck Surg 2018 Apr 25;47(1):28. Epub 2018 Apr 25.

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.

Background: Management of locoregional recurrence (LRR) and distant metastasis (DM) in adenoid cystic carcinoma (ACC) is guided by limited data. We investigated mortality risks in patients diagnosed and treated for recurrent ACC.

Methods: A retrospective review of ACC patients treated from 1989 to 2016 identified 36 patients with LRR or DM. Read More

Surg Oncol 2018 Mar 2;27(1):44-53. Epub 2017 Dec 2.

Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia; Central Clinical School, University of Sydney, New south Wales, Australia.

Metastases to the parotid gland are the commonest cause of parotid malignancies in many regions of the world including Australia. The most common etiology of these metastases is head and neck cutaneous squamous cell carcinoma (HNcSCC) followed by melanoma of the head and neck. This article focuses on the management of the aforementioned pathologies including Merkel cell carcinoma (MCC). Read More

Laryngoscope 2018 09 26;128(9):2076-2083. Epub 2018 Feb 26.

University of Melbourne, Parkville, Victoria, Australia.

Objectives/hypothesis: The outcomes of unilateral radiotherapy treatment for patients with p16/HPV-positive squamous cell carcinomas of unknown primary (SCCUP) affecting cervical lymph nodes are under-reported. Compared to radiating large volumes of the pharyngeal axis (the more common approach), this is potentially a much less toxic treatment for a good prognosis group.

Study Design: Retrospective cohort study. Read More

Am J Otolaryngol 2018 May - Jun;39(3):257-260. Epub 2018 Feb 7.

Department of Radiation Oncology, University of California, Los Angeles, David Geffen School of Medicine, United States. Electronic address:

Purpose: To evaluate the prognostic significance of human papillomavirus (HPV) status among patients treated by salvage radiation therapy for local-regional recurrences and second primary cancers of the head and neck arising in a previously irradiated field.

Methods And Materials: The medical records of 54 consecutive patients who underwent re-irradiation for squamous cell carcinoma of the head and neck occurring in a previously irradiated field were reviewed. Only patients with biopsy-proven evidence of recurrent disease that had previously been treated with doses of radiation therapy of at least 60 Gy were included. Read More

ORL J Otorhinolaryngol Relat Spec 2018 9;80(1):10-18. Epub 2018 Feb 9.

Department of Head and Neck Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Introduction: The concept of neck dissection (ND) in the management armamentarium of head and neck squamous cell carcinoma has evolved throughout the years. Nowadays, ND becomes more functional.

Methodology: A retrospective study of 865 patients was performed at Netherlands Cancer Institute-Antoni Van Leeuwenhoek Hospital to investigate the feasibility of selective ND (SND). Read More

Am J Otolaryngol 2018 Mar - Apr;39(2):223-227. Epub 2018 Feb 2.

Washington University, Department of Otolaryngology-Head and Neck Surgery, Saint Louis, MO, United States.

Purpose: To determine the oncologic and functional outcomes of patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma after initial management with surgery and adjuvant therapy.

Data Sources: Ovid Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, Cochrane Database of Systematic Reviews, and Clinicaltrials.gov. Read More

Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151

Otorhinolaryngology - Head and Neck Surgery, Leuven Cancer Institute, University Hospitals Leuven.

Purpose Of Review: The review puts new information on geno- and phenotype of salivary duct carcinoma (SDC) in the perspective of the updated 2017 WHO classification.

Recent Findings: The proportion of SDC is increasing. This may be because of a true rise in incidence, but certainly to better diagnostic tests and changed WHO definitions. Read More

J Am Acad Dermatol 2018 03 10;78(3):560-578. Epub 2018 Jan 10.

Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This document provides evidence-based recommendations for the management of patients with cSCC. Read More

J Am Acad Dermatol 2018 03 10;78(3):540-559. Epub 2018 Jan 10.

Department of Family Medicine, University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan.

Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. Read More

Hong Kong Med J 2018 02 12;24(1):25-31. Epub 2018 Jan 12.

Department of Oncology, United Christian Hospital, Kwun Tong, Hong Kong.

Introduction: Angiosarcoma is a rare aggressive sarcoma that occurs mostly in the skin of the head and neck in the elderly population. The optimal management is dubious and most studies are from Caucasian populations. We aimed to examine the treatment and outcome of this disease in Chinese patients. Read More