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Br J Oral Maxillofac Surg 2020 Aug 27. Epub 2020 Aug 27.

Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, Naples, Italy.

Major salivary gland malignancies are rare, constituting 1%-3% of head-neck tumours. The surgical management of the clinically negative neck (cN0) does not have a univocal consensus yet. We have carried out a retrospective study on 119 cases of malignant parotid tumours that were surgically treated between January 1999 and January 2014. Read More

Curr Oncol 2021 Apr 29;28(3):1673-1680. Epub 2021 Apr 29.

Medical Oncology Department, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse, CEDEX 09, 31059 Toulouse, France.

Introduction: Recent modifications in the epidemiology of oropharyngeal squamous cell carcinoma (OSCC) have led to the increase of Human papillomavirus (HPV) related metastatic head and neck cancer patients with high life expectancy even at advanced stage, low comorbidity and still restricted systemic therapy opportunities. In the recent era of ablative therapies' development, oligometastatic HPV OSCC patients are indubitably good candidates for intensified treatment. However, data related to outcomes after optimised management of metastatic sites are dramatically missing. Read More

Eur J Surg Oncol 2021 Apr 16. Epub 2021 Apr 16.

Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands; Department of Maxillofacial Surgery, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

Background: The extent of surgical management of regional lymph nodes in the treatment of cutaneous head and neck melanoma on and anterior to O'Brien's watershed line is controversial. By comparing patients' cohorts of two separate melanoma expert centers we investigate the effectiveness of comprehensive versus (super-) selective neck dissection approach.

Methods: Sixty patients with macroscopic (palpable) neck node metastases (N2b) from anterior scalp and face melanoma were retrospectively studied. Read More

Front Oncol 2021 30;11:646167. Epub 2021 Mar 30.

Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan.

A low NM23-H1 expression in head and neck squamous cell carcinoma (HNSCC) was found to be associated with poor clinical outcome. Therefore, we investigated the role of NM23-H1 in the susceptibility of HNSCC cells to irradiation and its clinical significance. An study was also conducted to validate the results. Read More

J Med Case Rep 2021 Apr 11;15(1):156. Epub 2021 Apr 11.

Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumor involving mostly the head and neck region, and frequently the salivary glands. The development of lung metastasis after treatment of the primary tumor is a common occurrence in ACC. Although lung metastases show a slow rate of growth, approximately 10% of patients die from distant metastases. Read More

Anticancer Res 2021 Apr;41(4):2177-2182

School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.;

Background/aim: To investigate the impact of PDZ-binding kinase (PBK) on the clinical outcome of patients with oral squamous cell carcinoma (OSCC) who received radiotherapy.

Patients And Methods: PBK immunoreactivity of cancer specimens obtained from 179 patients with primary OSCC was analyzed by immunohistochemistry.

Results: High PBK expression in tumor cells tended to be associated with advanced N-stage. Read More

J Oral Pathol Med 2021 Apr 2. Epub 2021 Apr 2.

University of Hong Kong, Hong kong, China.

Background: Oral squamous cell carcinoma (OSCC) is the 15th most common cause of cancer-related mortality worldwide and approximately one oral cancer-related death occurs for every two new diagnoses. Death-due-to-disease is usually ascribed to inoperable primary tumours, treatment complications, second primary tumours arising due to field cancerization, or locoregional recurrence and distant metastases.

Methods: A retrospective review of OSCC patients treated over a 19-year period, betweenOctober 1 , 2000 and October 1 , 2019. Read More

Ann Surg 2020 09;272(3):496-503

Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Objective: The aim of this prospective randomized-controlled trial was to evaluate the risks/benefits of prophylactic central neck dissection (pCND) in patients with clinically node negative (cN0) papillary thyroid cancer (PTC).

Background: Microscopic lymph node involvement in patients with PTC is common, but the optimal management is unclear.

Methods: Sixty patients with cN0 PTC were randomized to a total thyroidectomy (TT) or a TT+ pCND. Read More

Tumori 2021 Mar 22:3008916211001438. Epub 2021 Mar 22.

Department of Gynaecologic Oncology, St James' University Hospital, Leeds, UK.

Background: Adult granulosa cell tumor (AGCT) of the ovary generally has a good prognosis. Recurrences tend to be late and confined to the abdominopelvis. Bone metastases are extremely rare. Read More

Gulf J Oncolog 2021 Jan;1(35):92-95

Dept. of Pathology, Jawaharlal Institute of Post Graduate Medical Education & Research (JIPMER), Puducherry.

Malignant mucosal melanoma (MM) is a rare and aggressive neoplasm, which behaves differently from its cutaneous counterpart. MM of head and neck account for 55.4%, genital tracts - 18%, ano-rectal - 23. Read More

Clin Transl Oncol 2021 Mar 9. Epub 2021 Mar 9.

Division of Radiation Oncology, IEO, European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141, Milan, Italy.

Background And Purpose: Renal cell carcinoma (RCC) has traditionally been considered radioresistant with a limited role for conventional fractionation as a local approach. Nevertheless, since the appearance of stereotactic body radiation therapy (SBRT), radiotherapy (RT) has been increasingly employed in the management of metastatic RCC (mRCC). The aim of this study was to evaluate the role of SBRT for synchronous and metachronous oligo metastatic RCC patients in terms of local control, delay of systemic treatment, overall survival and toxicity. Read More

ANZ J Surg 2021 Feb 26. Epub 2021 Feb 26.

Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Sydney, New South Wales, Australia.

Historically, patients with head and neck squamous cell carcinoma (HNSCC) with distant metastases were regarded as palliative. Oligometastasis (OM) refers to patients with a limited number of distant metastatic deposits. Treatment of patients with OMs has been reported in patients with lung, colon, breast, prostate and brain malignancies. Read More

Auris Nasus Larynx 2021 Feb 18. Epub 2021 Feb 18.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Nivolumab administration to patients with organ transplantation history requires careful management. Herein, we report the case of a living-donor liver-transplant recipient, a 52-year-old man, with recurrent and metastatic hypopharyngeal cancer treated with nivolumab. He was diagnosed with T2N2bM0 stage IVA hypopharyngeal squamous cell carcinoma. Read More

Otolaryngol Clin North Am 2021 Apr 15;54(2):357-368. Epub 2021 Feb 15.

Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

The incidence of Merkel cell carcinoma (MCC) continues to increase. Understanding of MCC biology has advanced rapidly, with current staging providing valuable prognostic information. MCC treatment often is multidisciplinary. Read More

Laryngoscope 2021 Feb 18. Epub 2021 Feb 18.

Division of Radiation Oncology, Department of Radiology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, U.S.A.

Objectives: Limited data is available on head and neck cancer (HNC) patients presenting with brain metastases (BM) at initial diagnosis. We sought to evaluate the incidence, management, and treatment outcomes of these patients using the National Cancer Database (NCDB).

Methods: We identified 465,925 patients diagnosed with HNC between 2010 and 2015 in the NCDB. Read More

Pract Radiat Oncol 2021 Feb 6. Epub 2021 Feb 6.

Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

Cardiac metastases pose clinical challenges for radiation oncologists given the need to balance the benefit of local therapy against the risks of cardiac toxicity in the setting of cardiac motion, respiratory motion, and nearby organs at risk. Stereotactic magnetic resonance-guided adaptive radiation therapy has recently become more commonly used, conferring benefits in tumor visualization for setup, real-time motion management monitoring, and enabling plan adaptation for daily changes in tumor and/or normal tissues. Given these benefits, we developed and implemented a workflow for local treatment of metastatic disease within the heart using stereotactic magnetic resonance-guided adaptive radiation therapy. Read More

JAMA Netw Open 2021 01 4;4(1):e2034065. Epub 2021 Jan 4.

Center for Radiological Research, Columbia University Irving Medical Center, New York, New York.

Importance: The coronavirus disease 2019 (COVID-19) pandemic has led to treatment delays for many patients with cancer. While published guidelines provide suggestions on which cases are appropriate for treatment delay, there are no good quantitative estimates on the association of delays with tumor control or risk of new metastases.

Objectives: To develop a simplified mathematical model of tumor growth, control, and new metastases for cancers with varying doubling times and metastatic potential and to estimate tumor control probability (TCP) and metastases risk as a function of treatment delay interval. Read More

J Cancer Res Clin Oncol 2021 May 20;147(5):1307-1313. Epub 2021 Jan 20.

Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center, IRCCS, Humanitas University, via Manzoni 56, 20089, Rozzano, MI, Italy.

Introduction: Recently major efforts have been made to define the oligometastatic setting, but for head and neck cancer (HNC) limited data are available. We aimed to evaluate outcome of oligometastatic HNC treated with Stereotactic body radiotherapy (SBRT) as metastasis-directed therapy.

Materials And Methods: We analyzed patients treated with SBRT on a maximum of five oligometastases from HNC, in up to two organs. Read More

Gulf J Oncolog 2020 Sep;1(34):39-47

Department of Medical Oncology Kuwait Cancer Control Center.

Introduction: Medullary thyroid cancers (MTC) constitute about 5% of all thyroid cancers. The 10-year overall survival (OS) rate of patients with localized disease in thyroid for this pathology is 80% to 90% which is comparable with differentiated thyroid cancers, figures drop to 75% for cases with nodal metastases. Only 20% of patients with distant metastases at diagnosis survive for 10 years. Read More

Front Oncol 2020 22;10:617793. Epub 2020 Dec 22.

Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Hematogenous dissemination represents a common manifestation of squamous cell carcinoma of the head and neck, and the recommended therapeutic options usually consist of systemically administered drugs with palliative intent. However, mounting evidence suggests that patients with few and slowly progressive distant lesions of small size may benefit from various local ablation techniques, which have already been established as standard-of-care modalities for example in colorectal and renal cell carcinomas and in sarcomas. In principle, serving as radical approaches to eradicate cancer, these interventions can be curative. Read More

J Neurol Surg B Skull Base 2020 Dec 12;81(6):701-708. Epub 2019 Sep 12.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, United States.

 Sinonasal adenocarcinoma (SNAC) is a rare malignancy arising from mucus-secreting glandular tissue. Limited large-scale studies are available due to its rarity. We evaluated SNAC in the National Cancer Database (NCDB), a source that affords multi-institutional, population studies of rare cancers and their outcomes. Read More

Eur Arch Otorhinolaryngol 2020 Dec 28. Epub 2020 Dec 28.

International Head and Neck Scientific Group, Padua, Italy.

Approximately 70-80% of patients with cT1-2N0 oral squamous cell carcinoma (OSCC) ultimately prove to have no cancer in the cervical lymphatics on final pathology after selective neck dissection. As a result, sentinel lymph node biopsy (SLNB) has been adopted during the last decade as a diagnostic staging method to intelligently identify patients who would benefit from formal selective lymphadenectomy or neck irradiation. While not yet universally accepted, SLNB is now incorporated in many national guidelines. Read More

Niger J Clin Pract 2020 Dec;23(12):1683-1689

Department of Radiation Oncology, Ankara City Hospital, Yildirim Beyazit University School of Medicine, Ankara, Turkey.

Objectives: The study aims to retrospectively review the survival and toxicity outcomes of adaptive helical tomotherapy (HT) treatment of nasopharyngeal carcinoma (NPC) patients over 5 years.

Methods: Between February 2010 and September 2017, 67 biopsy-proven non-metastatic NPC patients were analyzed. All patients except one received concurrent chemotherapy and treated with adaptive Simultaneous integrated boost- intensity-modulated radiation therapy (SIB-IMRT). Read More

Ann Med Surg (Lond) 2020 Dec 28;60:614-618. Epub 2020 Nov 28.

Division of Surgical Oncology, Department of Surgery, Dr Sardjito Hospital, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.

Introduction: Although differentiated thyroid cancers generally have a good prognosis, a small proportion of patients will have recurrent or progressive disease. Bone resorption due to thyroid cancer can cause significant challenges in the clinical management and rehabilitation.

Presented Case: Nearly total femur resorption was found as a first presentation in a patient with thyroid cancer. Read More

Semin Nucl Med 2021 Jan 7;51(1):50-58. Epub 2020 Aug 7.

Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA. Electronic address:

Fluorine-18 (F)-fluorodeoxyglucose (FDG) positron emission tomography fused with computed tomography (PET/CT) is a valuable tool in surgical planning for head and neck squamous cell carcinoma (HNSCC). If performed prior to biopsy or other surgical intervention, FDG-PET/CT has high sensitivity for the detection of the primary site in patients with cervical lymph node metastases from unknown primary origin and can be used to direct the surgical workup. FDG-PET/CT is superior to CT alone for detection of nodal metastases outside the expected pattern or distant metastases or second primary cancers and can greatly affect determination of appropriate management including surgical eligibility. Read More

Recent Pat Anticancer Drug Discov 2020 Nov 26. Epub 2020 Nov 26.

Department of Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong. China.

Background: Diagnosis of Leptomeningeal Metastases (LM) from Non-Small Cell Lung Cancer (NSCLC) is usually based on clinical symptoms, cerebral-spinal fluid (CSF) cytology, and neuro-imaging. However, early diagnosis of LM in NSCLC is challenging due to the low sensitivity of these approaches. The Next-Generation Sequencing (NGS) using CSF could help improve the diagnosis of LM and guide its treatment options. Read More

Front Oncol 2020 10;10:593164. Epub 2020 Nov 10.

International Head and Neck Scientific Group, Padua, Italy.

Background: Patients with metastases in the lymph nodes of the neck and no obvious primary tumor, neck cancer with unknown primary (NCUP), represent a management challenge. A majority of patients have metastatic squamous cell carcinoma (SCC), although other histologies do occur.

Methods: We comprehensively reviewed the literature, compared available guidelines, and conferred with an international team of experts. Read More

Oral Oncol 2021 01 10;112:105086. Epub 2020 Nov 10.

University of British Columbia, Department of Surgery, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada; BC Cancer Vancouver, Department of Radiation Oncology, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada. Electronic address:

Objectives: Brain metastases (BM) arising from head and neck cancer (HNC) are rare and not well characterized. This study aims to describe the clinicopathological features, treatments, prognostic factors, and survival in HNC patients with BM.

Materials And Methods: Non-thyroid HNC patients referred to BC Cancer from 1998 to 2016 were retrospectively reviewed for BM. Read More

Laryngoscope 2021 Jun 3;131(6):E1847-E1853. Epub 2020 Nov 3.

Department of Radiation Oncology, NYU Langone Health, New York, New York, U.S.A.

Objectives: The role of locoregional radiotherapy for metastatic oropharyngeal squamous cell cancer (OPSCC) is unclear. We investigated the impact of head and neck radiotherapy on survival in de novo metastatic OPSCC patients who received systemic therapy.

Methods: We queried the NCDB from 2004-2015 for metastatic OPSCC patients at diagnosis with known HPV-status who received systemic therapy. Read More

Int J Clin Oncol 2021 Feb 30;26(2):316-325. Epub 2020 Oct 30.

Department of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Background: The aims of this study are to evaluate the efficacy and safety of first-line treatment with chemotherapy plus cetuximab in real-world patients with recurrent or metastatic squamous cell carcinoma of the head and neck (RM-SCCHN) and to identify prognostic factors for overall survival (OS).

Methods: This is a prospective observation study involving 20 oncology institutions in Japan. Patients with RM-SCCHN treated with a first-line therapy consisting of cetuximab plus any chemotherapy regimen between December 2013 and February 2017 were enrolled. Read More