Int J Radiat Oncol Biol Phys 2022 Apr 5. Epub 2022 Apr 5.
Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048. Electronic address:
Background: Better understanding of the relationship between spread of head and neck squamous cell carcinoma (HNSCC) to regional lymph nodes (LN) and the frequency and manner of treatment failure should help design better treatment intensification strategies. In this study, we evaluate the relationship between recurrence patterns, mortality, and number of pathologically positive (+) LN in HNSCC in three prospective randomized controlled trials.
Methods: Secondary analysis of 947 HNSCC patients enrolled on XXX (N=410), XXX (N=203), and XXX (N=334) undergoing surgery and post-operative radiation +/- systemic therapy. Read More