365 results match your criteria Radiation Therapy General Principles


Management of Lung Cancer During the COVID-19 Pandemic.

JCO Oncol Pract 2020 May 26:OP2000286. Epub 2020 May 26.

Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.

Coronavirus disease 2019 (COVID-19) has had a devastating impact around the world. With high rates of transmission and no curative therapies or vaccine yet available, the current cornerstone of management focuses on prevention by social distancing. This includes decreased health care contact for patients. Read More

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http://dx.doi.org/10.1200/OP.20.00286DOI Listing

Magnetic resonance imaging of the prostate after focal therapy with high-intensity focused ultrasound.

Abdom Radiol (NY) 2020 May 23. Epub 2020 May 23.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, 10065, USA.

For clinically significant, locally confined prostate cancer, whole-gland radical prostatectomy and radiotherapy are established effective treatment strategies that, however, come at a cost of significant morbidity related to urinary and sexual side effects. The concept of risk stratification paired with a better understanding of prognostic factors has led to the development of alternative management options including active surveillance and focal therapy for appropriately selected patients with localized disease. High-intensity focused ultrasound (HIFU) is one such minimally invasive, image-guided treatment option for prostate cancer. Read More

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http://dx.doi.org/10.1007/s00261-020-02577-5DOI Listing

Chapitre 9. Oncofertilité et jeunes filles prépubères : Un « droit à un avenir ouvert » ?

J Int Bioethique Ethique Sci 2019 Nov;Vol. 30(3):159-177

Chemotherapy and radiotherapy have increased the life expectancy of cancer patients but may cause premature ovarian failure and irreversible loss of fertility. In the context of childhood cancers, it is now acknowledged that possible negative effects of treatment on future reproductive autonomy are a major concern. While a few options are open to patients post-puberty, the only option currently open to prepubescent girls is cryopreservation of ovarian tissue and subsequent transplantation. Read More

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http://dx.doi.org/10.3917/jibes.303.0159DOI Listing
November 2019

[Pre-, Post- and Intraoperative Radiation Therapy in Adult Liposarcomas].

Authors:
Falk Roeder

Zentralbl Chir 2020 Apr 8;145(2):148-159. Epub 2020 Apr 8.

Klinik für Radiotherapie und Radioonkologie, Paracelsus Medizinische Privatuniversität, Landeskrankenhaus, Salzburg, Österreich.

Radiation therapy is an integral part of the treatment of soft tissue sarcomas in adults. The indication for additional radiation therapy has usually been based on known general prognostic factors, such as tumour size, localisation, grading and (anticipated) resection margin. Increasing attention has recently been paid to the role of the histological subtype. Read More

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http://dx.doi.org/10.1055/a-1117-3984DOI Listing

Photodynamic Therapy for the Treatment of Glioblastoma.

Front Surg 2019 21;6:81. Epub 2020 Jan 21.

Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States.

Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is nearly universal within 2 years of diagnosis. Read More

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http://dx.doi.org/10.3389/fsurg.2019.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985206PMC
January 2020

MiR-450a-5p inhibits autophagy and enhances radiosensitivity by targeting dual-specificity phosphatase 10 in esophageal squamous cell carcinoma.

Cancer Lett 2020 Jul 31;483:114-126. Epub 2020 Jan 31.

Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China. Electronic address:

Radioresistance reduces the success of therapy for patients with ESCC. Enhancing our understanding of the cardinal principles of radioresistance may improve the response of patients to irradiation. MicroRNAs perform a key role in posttranscriptional regulation, which is linked with the response of tumors to irradiation. Read More

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http://dx.doi.org/10.1016/j.canlet.2020.01.037DOI Listing

An introduction to deep learning in medical physics: advantages, potential, and challenges.

Phys Med Biol 2020 Mar 3;65(5):05TR01. Epub 2020 Mar 3.

Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States of America. Innovative Technology Of Radiotherapy Computation and Hardware (iTORCH) Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.

As one of the most popular approaches in artificial intelligence, deep learning (DL) has attracted a lot of attention in the medical physics field over the past few years. The goals of this topical review article are twofold. First, we will provide an overview of the method to medical physics researchers interested in DL to help them start the endeavor. Read More

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http://dx.doi.org/10.1088/1361-6560/ab6f51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101509PMC

[Chapitre 9. Oncofertility and prepubescent girls: A ‘right to an open future’?.]

J Int Bioethique Ethique Sci 2019 09;30(3):159-177

Chemotherapy and radiotherapy have increased the life expectancy of cancer patients but may cause premature ovarian failure and irreversible loss of fertility. In the context of childhood cancers, it is now acknowledged that possible negative effects of treatment on future reproductive autonomy are a major concern. While a few options are open to patients post-puberty, the only option currently open to prepubescent girls is cryopreservation of ovarian tissue and subsequent transplantation. Read More

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http://dx.doi.org/10.3917/jibes.303.0159DOI Listing
September 2019

[Comprehensive treatment based on oncology principles should also be emphasized for treating gallbladder cancer].

Authors:
D Zhou Z W Quan

Zhonghua Wai Ke Za Zhi 2020 Jan;58(1):27-30

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

Gallbladder carcinoma(GBC) is one of the most malignant cancers of the digestive system with very poor prognosis due to its histopathological features of easy invasion to the liver, early lymph node metastasis and nerve infiltration, which result in low resection rate. It has been confirmed that radical surgery only makes sense to relatively early GBC in improving prognosis of patients. Therefore, based on recognition of biological characteristics of GBC and the theories of oncology, efforts should be focused on developing various adjuvant treatment methods for treating GBC including chemotherapy, radiotherapy, targeted therapy and immunotherapy. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2020.01.007DOI Listing
January 2020

[Prostate cryotherapy: General principles.]

Arch Esp Urol 2019 Oct;72(8):816-824

Unidad de Andrología y Cirugía Reconstructiva Uretro-Genital. Servicio de Urología. Hospital General Universitario Gregorio Marañón. Madrid. España.

Introduction: Prostate cryotherapy has been consolidated as an alternative minimally invasive treatment.

Objective: To exposed its historical development, its action mechanism and the surgical technique. Regarding its indications, we expose the different option of treatment- primary cryotherapy, salvage and focal- emphasizing its oncological results in the absence of randomized studies. Read More

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October 2019
1 Read

Chinese guidelines on management of hepatic encephalopathy in cirrhosis.

World J Gastroenterol 2019 Sep;25(36):5403-5422

Department of Pathogenic Biology, Peking University Health Science Center, Beijing 100191, China.

The Chinese Society of Hepatology developed the current guidelines on the management of hepatic encephalopathy in cirrhosis based on the published evidence and the panelists' consensus. The guidelines provided recommendations for the diagnosis and management of hepatic encephalopathy (HE) including minimal hepatic encephalopathy (MHE) and overt hepatic encephalopathy, emphasizing the importance on screening MHE in patients with end-stage liver diseases. The guidelines emphasized that early identification and timely treatment are the key to improve the prognosis of HE. Read More

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http://dx.doi.org/10.3748/wjg.v25.i36.5403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767982PMC
September 2019
2 Reads

Communicating the External Beam Radiation Experience (CEBRE): Perceived Benefits of a Graphic Narrative Patient Education Tool.

Pract Radiat Oncol 2019 Sep 11. Epub 2019 Sep 11.

Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois. Electronic address:

Purpose: Current radiation oncology patient education materials exceed national readability recommendations. A graphic narrative educational tool, the Communicating the External Beam Radiation Experience (CEBRE) discussion guide, was developed to facilitate patient-provider communication. A pilot study evaluated perceived benefits of CEBRE for patients and physicians. Read More

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http://dx.doi.org/10.1016/j.prro.2019.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064379PMC
September 2019

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2019 09;17(9):1109-1133

National Comprehensive Cancer Network.

Small bowel adenocarcinoma (SBA) is a rare malignancy of the gastrointestinal tract that has increased in incidence across recent years. Often diagnosed at an advanced stage, outcomes for SBA are worse on average than for other related malignancies, including colorectal cancer. Due to the rarity of this disease, few studies have been done to direct optimal treatment, although recent data have shown that SBA responds to treatment differently than colorectal cancer, necessitating a separate approach to treatment. Read More

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http://dx.doi.org/10.6004/jnccn.2019.0043DOI Listing
September 2019
6 Reads

Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention.

Authors:
Emmanouil S Brilakis Kambis Mashayekhi Etsuo Tsuchikane Nidal Abi Rafeh Khaldoon Alaswad Mario Araya Alexandre Avran Lorenzo Azzalini Avtandil M Babunashvili Baktash Bayani Ravinay Bhindi Nicolas Boudou Marouane Boukhris Nenad Ž Božinović Leszek Bryniarski Alexander Bufe Christopher E Buller M Nicholas Burke Heinz Joachim Büttner Pedro Cardoso Mauro Carlino Evald H Christiansen Antonio Colombo Kevin Croce Felix Damas de Los Santos Tony De Martini Joseph Dens Carlo Di Mario Kefei Dou Mohaned Egred Ahmed M ElGuindy Javier Escaned Sergey Furkalo Andrea Gagnor Alfredo R Galassi Roberto Garbo Junbo Ge Pravin Kumar Goel Omer Goktekin Luca Grancini J Aaron Grantham Colm Hanratty Stefan Harb Scott A Harding Jose P S Henriques Jonathan M Hill Farouc A Jaffer Yangsoo Jang Risto Jussila Artis Kalnins Arun Kalyanasundaram David E Kandzari Hsien-Li Kao Dimitri Karmpaliotis Hussien Heshmat Kassem Paul Knaapen Ran Kornowski Oleg Krestyaninov A V Ganesh Kumar Peep Laanmets Pablo Lamelas Seung-Whan Lee Thierry Lefevre Yue Li Soo-Teik Lim Sidney Lo William Lombardi Margaret McEntegart Muhammad Munawar José Andrés Navarro Lecaro Hung M Ngo William Nicholson Göran K Olivecrona Lucio Padilla Marin Postu Alexandre Quadros Franklin Hanna Quesada Vithala Surya Prakasa Rao Nicolaus Reifart Meruzhan Saghatelyan Ricardo Santiago George Sianos Elliot Smith James C Spratt Gregg W Stone Julian W Strange Khalid Tammam Imre Ungi Minh Vo Vu Hoang Vu Simon Walsh Gerald S Werner Jason R Wollmuth Eugene B Wu R Michael Wyman Bo Xu Masahisa Yamane Luiz F Ybarra Robert W Yeh Qi Zhang Stephane Rinfret

Circulation 2019 07 29;140(5):420-433. Epub 2019 Jul 29.

McGill University Health Centre, McGill University, Montreal, QC, Canada (S.R.).

Outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have improved because of advancements in equipment and techniques. With global collaboration and knowledge sharing, we have identified 7 common principles that are widely accepted as best practices for CTO-PCI.  1. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039797DOI Listing
July 2019
37 Reads
14.430 Impact Factor

Clinical factors affecting the survival of patients diagnosed with non-small cell lung cancer and metastatic malignant pleural effusion, treated with hyperthermic intrathoracic chemotherapy or chemical talc pleurodesis: a monocentric, prospective, randomized trial.

J Thorac Dis 2019 May;11(5):1788-1798

Department of Thoracic Surgery, St' James' University Hospital, Bexley Wing, Leeds, UK.

Background: There is a plethora of treatment algorithms for managing patients with malignant pleural effusions (MPEs), sharing many common points and principles. Our study aims to compare hyperthermic intrapleural chemotherapy (HITHOC) and talc pleurodesis (TALC), as treatment options for patients with non-small cell lung cancer (NSCLC) and metastatic MPE.

Methods: This prospective, randomized trial was conducted at a single thoracic surgery center, the "Theagenio" Cancer Institute, in Greece, under the identification code NCT01409551 and was completed. Read More

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http://dx.doi.org/10.21037/jtd.2019.05.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588789PMC
May 2019
4 Reads

A general practitioner's guide to hematopoietic stem-cell transplantation.

Authors:
A Bazinet G Popradi

Curr Oncol 2019 06 1;26(3):187-191. Epub 2019 Jun 1.

Division of Hematology, McGill University Health Centre, Montreal, QC.

Hematopoietic stem-cell transplantation (hsct) is a medical procedure that consists of infusing stem cells after a short course of chemotherapy or radiotherapy, or both. It can be used in the treatment of various cancers, as well as some benign conditions. In the present review, we discuss the various types of hsct and their main indications. Read More

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http://dx.doi.org/10.3747/co.26.5033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588058PMC
June 2019
3 Reads

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma.

Klin Padiatr 2019 05 20;231(3):107-135. Epub 2019 May 20.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Heidelberg.

Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically heterogeneous group of pediatric brain tumors of WHO grades I and II occurring throughout all pediatric age groups and at all central nervous system (CNS) sites. The tumors are characterized by a slow growth rate and may show periods of growth arrest. Around 40% of all LGG patients can be cured by complete neurosurgical resection and are followed by close observation. Read More

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http://dx.doi.org/10.1055/a-0889-8256DOI Listing
May 2019
16 Reads

Current Status and Growth of Nuclear Theranostics in Singapore.

Nucl Med Mol Imaging 2019 Apr 25;53(2):96-101. Epub 2019 Jan 25.

1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, 1 Outram Road, Singapore, 169608 Singapore.

The concept of theranostics, where individual patient-level biological information is used to choose the optimal therapy for that individual, has become more popular in the modern era of 'personalised' medicine. With the growth of theranostics, nuclear medicine as a specialty is uniquely poised to grow along with the ever-increasing number of concepts combining imaging and therapy. This special report summarises the status and growth of Theranostic Nuclear Medicine in Singapore. Read More

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http://dx.doi.org/10.1007/s13139-019-00580-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473098PMC
April 2019
25 Reads

Palliative radiation oncology programs: design, build, succeed!

Ann Palliat Med 2019 Jul 11;8(3):264-273. Epub 2019 Mar 11.

Department of Radiation Oncology, Medical College of Wisconsin, Wauwatosa, WI, USA.

The palliation of symptoms caused by advanced cancer is one of the most common indications for radiation therapy. Radiation therapy is an efficient and effective treatment for the palliation of pain, bleeding, obstruction, compression of nerves or the spinal cord and other local symptoms caused by tumors. The general principles of palliative radiation therapy are to use the shortest course of palliative radiation therapy needed to achieve the desired goal. Read More

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http://dx.doi.org/10.21037/apm.2018.12.09DOI Listing
July 2019
5 Reads

Treatment of Stage I Hard Palate Cancer with High-Dose-Rate Brachytherapy Using Molds: Cost-Based Perspective.

J Pharm Bioallied Sci 2019 Feb;11(Suppl 1):S67-S71

Department of Oral and Maxillofacial Pathology, MNR Dental College and Hospital, Sangareddy, Telangana, India.

Introduction: Treatment of T1N0M0 (T1 = greatest tumor size < 2 cm, N0 = regional lymph nodes not palpable by clinical examination, M0 = No evidence of distant metastasis) (Green FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, Morrow M. AJCC Cancer Staging Manual. New York: Springer; 2002) lesions of hard palate carcinoma by radiotherapy carries equal results with the advantage of cosmesis and can avoid surgical complications. Read More

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http://dx.doi.org/10.4103/jpbs.JPBS_193_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398313PMC
February 2019
5 Reads

Mechanisms and therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy.

Cancer Lett 2019 06 19;452:66-70. Epub 2019 Mar 19.

Liver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, PR China. Electronic address:

Immunotherapies based on T cells have gained significant success in the treatment of diverse cancers, however, several limitations also exist, including low response, acquired resistance and severe side effects, which lead to unfavorable outcomes. Recent studies found that traditional therapies, radiotherapy and/or chemotherapy may affect the immune condition in situ and cause abscopal effect, which may improve the response of immunotherapies, enhance the efficiency, and reduce the untoward effect. Here, we review the mechanisms uncovering the cancer immunotherapy and immunogenic effects of radiotherapy and chemotherapy, aiming to highlight the principles underlying the therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy and ultimately guide better designs for future synergistic cancer therapies. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.048DOI Listing
June 2019
7 Reads
5.621 Impact Factor

Controversies, Consensus, and Collaboration in the Use of I Therapy in Differentiated Thyroid Cancer: A Joint Statement from the American Thyroid Association, the European Association of Nuclear Medicine, the Society of Nuclear Medicine and Molecular Imaging, and the European Thyroid Association.

Thyroid 2019 04;29(4):461-470

19 Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.

Background: Publication of the 2015 American Thyroid Association (ATA) management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer was met with disagreement by the extended nuclear medicine community with regard to some of the recommendations related to the diagnostic and therapeutic use of radioiodine (I). Because of these concerns, the European Association of Nuclear Medicine and the Society of Nuclear Medicine and Molecular Imaging declined to endorse the ATA guidelines. As a result of these differences in opinion, patients and clinicians risk receiving conflicting advice with regard to several key thyroid cancer management issues. Read More

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http://dx.doi.org/10.1089/thy.2018.0597DOI Listing
April 2019
44 Reads

B7-H3-targeted radioimmunotherapy of human cancer.

Curr Med Chem 2019 Feb 28. Epub 2019 Feb 28.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama. United States.

Background: Targeted radioimmunotherapy (RIT) is an attractive approach to selectively localize therapeutic radionuclides to malignant cells within primary and metastatic tumors while sparing normal tissues from the effects of radiation. Many human malignancies express B7-H3 on the tumor cell surface, while expression on the majority of normal tissues is limited, presenting B7-H3 as a candidate target for RIT. This review provides an overview of the general principles of targeted RIT and discusses publications that have used radiolabeled B7-H3-targeted antibodies for RIT of cancer in preclinical or clinical studies. Read More

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http://dx.doi.org/10.2174/0929867326666190228120908DOI Listing
February 2019
4 Reads

Calculation of absorbed dose in radiotherapy by solution of the linear Boltzmann transport equations.

Authors:
James L Bedford

Phys Med Biol 2019 01 10;64(2):02TR01. Epub 2019 Jan 10.

Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London SM2 5PT, United Kingdom.

Over the last decade, dose calculations which solve the linear Boltzmann transport equations have been introduced into clinical practice and are now in widespread use. However, knowledge in the radiotherapy community concerning the details of their function is limited. This review gives a general description of the linear Boltzmann transport equations as applied to calculation of absorbed dose in clinical radiotherapy. Read More

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http://dx.doi.org/10.1088/1361-6560/aaf0e2DOI Listing
January 2019
4 Reads

My best case: homeopathic management of adverse effects of tamoxifen.

Wien Med Wochenschr 2018 Dec 11. Epub 2018 Dec 11.

General Practice Department, Faculty of Medicine, Strasbourg University, Strasbourg, France.

Background: Nearly half of patients discontinue tamoxifen hormone therapy early because of side effects, thus increasing the risk of breast cancer recurrence. Could a homeopathic treatment improve compliance?

Methods: A patient suffering from side effects of tamoxifen was seen in consultation every 2 months for 10 months by a senior homeopathic doctor and a registrar.

Results: Case analysis and repertorisation led to the identification of Pulsatilla as the simillimum drug and tamoxifen 7c as the etiological treatment. Read More

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http://link.springer.com/10.1007/s10354-018-0672-9
Publisher Site
http://dx.doi.org/10.1007/s10354-018-0672-9DOI Listing
December 2018
25 Reads

Chemo-Radiation After Upfront Rectal Resections-a Clinical Dilemma.

Indian J Surg Oncol 2018 Dec 18;9(4):495-500. Epub 2018 Aug 18.

Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra 400012 India.

To compare the impact of adjuvant chemo-radiotherapy (ACRT) versus adjuvant chemotherapy (ACT) alone on recurrence and survival in patients with stage II and III rectal adenocarcinoma undergoing upfront curative resection. Prospective observational review of colorectal database at Tata Memorial Hospital from July 2010 to March 2015 identified 84 patients who underwent upfront curative resection for stage II or III rectal cancer. None of the patient received preoperative chemo-radiation. Read More

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http://dx.doi.org/10.1007/s13193-018-0805-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265169PMC
December 2018
4 Reads

Deep learning in medical imaging and radiation therapy.

Med Phys 2019 Jan 20;46(1):e1-e36. Epub 2018 Nov 20.

Department of Radiology, University of Chicago, Chicago, IL, 60637, USA.

The goals of this review paper on deep learning (DL) in medical imaging and radiation therapy are to (a) summarize what has been achieved to date; (b) identify common and unique challenges, and strategies that researchers have taken to address these challenges; and (c) identify some of the promising avenues for the future both in terms of applications as well as technical innovations. We introduce the general principles of DL and convolutional neural networks, survey five major areas of application of DL in medical imaging and radiation therapy, identify common themes, discuss methods for dataset expansion, and conclude by summarizing lessons learned, remaining challenges, and future directions. Read More

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http://doi.wiley.com/10.1002/mp.13264
Publisher Site
http://dx.doi.org/10.1002/mp.13264DOI Listing
January 2019
122 Reads

Place of Sterotactic Radiotherapy in Treatment of Extramedullary Plasmocytoma.

J Craniofac Surg 2018 Nov;29(8):e807

Kayseri Education and Research Hospital, Department of Radiation Oncology, Kayseri, Turkey.

In conclusion, extramedullary plasmacytoma (EMPs) initially develop as localized disease. These tumors are quite sensitive to radiotherapy (RT) and the response is often complete recovery after RT. In addition, highly sensitive, conformal radiosurgery can be preferred to conventional RT; however, further studies are needed to define indications and therapeutic fractions in stereotactic RT of plasmacytoma since guidelines and clinical trials are lacking. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004844DOI Listing
November 2018
11 Reads

Multidisciplinary teams for the proper management of patients with genitourinary tumors: When topics set scientific societies' agenda.

Tumori 2019 Apr 5;105(2):161-167. Epub 2018 Jul 5.

1 Prostate Cancer Unit, Prostate Cancer Programme, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Introduction: The multidisciplinary management of oncologic patients is identified as the bottom line element of quality in tumor care.

Methods: In 2015, 7 Italian scientific societies representing the specialists involved in the diagnosis and treatment of genitourinary tumors joined efforts in the Italian uro-oncologic multidisciplinary teams (MDTs) project. The aims were to promote the reorganization of genitourinary cancer care, switching to a multidisciplinary approach, reach a consensus on the core elements for the setup of MDTs in genitourinary oncology, and support health policy makers and managers in remodeling of the assistance and care of uro-oncologic patients on a national level. Read More

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http://dx.doi.org/10.1177/0300891618784789DOI Listing
April 2019
30 Reads

Can Endorectal Ultrasound, MRI, and Mucosa Integrity Accurately Predict the Complete Response for Mid-Low Rectal Cancer After Preoperative Chemoradiation? A Prospective Observational Study from a Single Medical Center.

Dis Colon Rectum 2018 08;61(8):903-910

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Patients with locally advanced rectal cancer could be managed by a watch-and-wait approach if they achieve clinical complete response after preoperative chemoradiotherapy. Mucosal integrity, endorectal ultrasound, and rectal MRI are used to evaluate clinical complete response; however, the accuracy remains questionable. Clinical practice based on those assessment methods needs more data and discussion. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001135DOI Listing
August 2018
73 Reads
3.750 Impact Factor

Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy.

Semin Radiat Oncol 2018 06;28(3):256-263

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Current clinical implementation of proton radiation therapy assumes a constant relative biological effectiveness (RBE) value of 1.1 throughout the treatment field, for both the target and organs at risks. Although few in vivo clinical data suggest that this approximation is clinically significant, in vitro studies demonstrate the dependency of RBE on dose, fractionation, proton energy, and linear energy transfer, as well as patient radiosensitivity and definition of endpoint. Read More

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http://dx.doi.org/10.1016/j.semradonc.2018.02.010DOI Listing
June 2018
4 Reads

Principles and practice of high-dose rate penile brachytherapy: Planning and delivery techniques.

Pract Radiat Oncol 2018 Nov - Dec;8(6):e386-e391. Epub 2018 Jun 8.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.

Purpose: To allow for organ preservation, high-dose rate (HDR) brachytherapy may be used in the treatment of localized penile cancer. Penile cancer is a rare malignancy that accounts for <1% of cancers in men in the United States. The standard treatment for localized disease is partial amputation of the penis. Read More

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http://dx.doi.org/10.1016/j.prro.2018.06.002DOI Listing
January 2019
56 Reads

Precision cardio-oncology: understanding the cardiotoxicity of cancer therapy.

NPJ Precis Oncol 2017 12;1(1):31. Epub 2017 Sep 12.

3Professor of Biochemistry and Director, Zhengzhou Central Laboratory of Antibody Research, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan China.

Current oncologic treatments have brought a strong reduction in mortality in cancer patients. However, the cancer therapy-related cardiovascular complications, in particular chemo-therapy and radiation therapy-induced cardiotoxicities are a major cause of morbidity and mortality in people living with or surviving cancer. The simple fact is that all antineoplastic agents and radiation therapy target tumor cells but also result in collateral damage to other tissues including the cardiovascular system. Read More

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http://dx.doi.org/10.1038/s41698-017-0034-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871905PMC
September 2017
31 Reads

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice .

Nanomaterials (Basel) 2018 Jun 3;8(6). Epub 2018 Jun 3.

ICCOM-CNR via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy.

Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Read More

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http://www.mdpi.com/2079-4991/8/6/401
Publisher Site
http://dx.doi.org/10.3390/nano8060401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027353PMC
June 2018
12 Reads

The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology guidelines for the management of patients with cervical cancer.

Radiother Oncol 2018 Jun 1;127(3):404-416. Epub 2018 May 1.

University Hospital, Careggi, Florence, Italy.

Background: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer.

Objective: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.03.003DOI Listing
June 2018
50 Reads

The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology Guidelines for the Management of Patients with Cervical Cancer.

Virchows Arch 2018 Jun 4;472(6):919-936. Epub 2018 May 4.

University Hospital, Careggi, Florence, Italy.

Background: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer.

Objective: The European Society of Gynecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide. Read More

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http://dx.doi.org/10.1007/s00428-018-2362-9DOI Listing
June 2018
62 Reads

Epigenetic agents in combined anticancer therapy.

Future Med Chem 2018 05 20;10(9):1113-1130. Epub 2018 Apr 20.

First Faculty of Medicine, Charles University in Prague, Kateřinská 32, 121 08, Prague 2, Czech Republic.

In the last decade, epigenetic drugs (such as inhibitors of DNA methyltransferases and histone deacetylases) have been intensively used for cancer treatment. Their applications have shown high anticancer effectivity and tolerable side effects. However, they are unfortunately not effective in the treatment of some types and phenotypes of cancers. Read More

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http://dx.doi.org/10.4155/fmc-2017-0203DOI Listing
May 2018
25 Reads

Gamma knife radiosurgery for arteriovenous malformations: general principles and preliminary results in a Swiss cohort.

Swiss Med Wkly 2018 3;148:w14602. Epub 2018 Apr 3.

University of Lausanne, Faculty of Biology and Medicine, Lausanne, Switzerland / Department of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Centre, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Introduction: Arteriovenous malformations (AVMs) are a type of vascular malformation characterised by an abnormal connection between arteries and veins, bypassing the capillary system. This absence of capillaries generates an elevated pressure (hyperdebit), in both the AVM and the venous drainage, increasing the risk of rupture. Management modalities are: observation, microsurgical clipping, endovascular treatment and radiosurgery. Read More

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http://dx.doi.org/10.4414/smw.2018.14602DOI Listing
October 2018
16 Reads

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.

Trends Cancer 2018 04 13;4(4):292-319. Epub 2018 Mar 13.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Physical forces have a crucial role in tumor progression and cancer treatment. The application of principles of engineering and physical sciences to oncology has provided powerful insights into the mechanisms by which these forces affect tumor progression and confer resistance to delivery and efficacy of molecular, nano-, cellular, and immuno-medicines. Here, we discuss the mechanics of the solid and fluid components of a tumor, with a focus on how they impede the transport of therapeutic agents and create an abnormal tumor microenvironment (TME) that fuels tumor progression and treatment resistance. Read More

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http://dx.doi.org/10.1016/j.trecan.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930008PMC
April 2018
5 Reads

Meningiomas: Overview and New Directions in Therapy.

Semin Neurol 2018 02 16;38(1):112-120. Epub 2018 Mar 16.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

The majority of meningiomas, the most common primary brain tumor, are considered to be benign, and characteristic magnetic resonance imaging features allow a preliminary diagnosis. Meningiomas can be classified in the World Health Organization system as grade I, II, or III, depending on various histological features. In many cases, observation is the preferred management option, although this means the absence of a histological diagnosis. Read More

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http://dx.doi.org/10.1055/s-0038-1636502DOI Listing
February 2018
5 Reads

Identifying and managing the risks of medical ionizing radiation in endourology.

Can J Urol 2018 02;25(1):9154-9160

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Introduction: The risks of exposure to medical ionizing radiation is of increasing concern both among medical professionals and the general public. Patients with nephrolithiasis are exposed to high levels of ionizing radiation through both diagnostic and therapeutic modalities. Endourologists who perform a high-volume of fluoroscopy guided procedures are also exposed to significant quantities of ionizing radiation. Read More

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February 2018
22 Reads

Ultrasonography as a Diagnostic, Therapeutic, and Research Tool in Orthopaedic Surgery.

J Am Acad Orthop Surg 2018 Mar;26(6):187-196

From the Department of Orthopaedic Surgery (Dr. Li and Ms. Curry) and the Department of Radiology, Boston University School of Medicine, Boston, MA (Dr. Murakami), and the Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD (Dr. Yi).

Ultrasonography is an imaging modality that facilitates the diagnosis of pathology and injection therapy without exposing the patient to radiation. In addition, ultrasonography has become popular because of its portability, low cost, and production of real-time tomographic images that provide a cross-sectional view of anatomic structures. Despite its benefits and widespread adoption in general medicine and other specialties, however, ultrasonography is not as well adapted as a diagnostic and research tool in orthopaedic surgery. Read More

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http://dx.doi.org/10.5435/JAAOS-D-16-00221DOI Listing
March 2018
6 Reads

Re-irradiation in Gynaecological Malignancies: A Review.

Authors:
A H Sadozye

Clin Oncol (R Coll Radiol) 2018 02 9;30(2):110-115. Epub 2017 Dec 9.

Beatson West of Scotland Cancer Centre, Gartnavel General Hospital, Glasgow, UK. Electronic address:

Re-irradiation in gynaecological malignancies has become an increasingly frequent consideration. This can be delivered in multiple settings, with the most common being a patient with a history of cervical cancer developing a new vaginal cancer or endometrial cancer with local recurrence after hysterectomy and adjuvant pelvic radiation. A systematic review of the literature has unearthed a handful of reports, most delivering brachytherapy, with a small number on both external beam radiotherapy and stereotactic ablative radiotherapy. Read More

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http://dx.doi.org/10.1016/j.clon.2017.11.013DOI Listing
February 2018
4 Reads

Re-irradiation for recurrent glioma- the NCI experience in tumor control, OAR toxicity and proposal of a novel prognostic scoring system.

Radiat Oncol 2017 Nov 29;12(1):191. Epub 2017 Nov 29.

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD, 20892, USA.

Purpose/objectives: Despite mounting evidence for the use of re-irradiation (re-RT) in recurrent high grade glioma, optimal patient selection criteria for re-RT remain unknown. We present a novel scoring system based on radiobiology principles including target independent factors, the likelihood of target control, and the anticipated organ at risk (OAR) toxicity to allow for proper patient selection in the setting of recurrent glioma.

Materials/methods: Thirty one patients with recurrent glioma who received re-RT (2008-2016) at NCI - NIH were included in the analysis. Read More

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http://dx.doi.org/10.1186/s13014-017-0930-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707810PMC
November 2017
22 Reads

Training Canadian surgeons in oncoplastic breast surgery: Where do we stand?

Can J Surg 2017 12;60(6):369-371

From the Division of Surgical Oncology, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Khayat, Brackstone); the Division of Surgical Oncology, Nebraska Medical Center, Omaha, NE (Maxwell); the Department of Surgery, Royal Victoria Regional Health Centre, Barrie, Ont. (Hanrahan); the Division of General Surgery, Trillium Health Partners, Mississauga, Ont. (Richardson, Kappala); and the Division of Surgical Oncology, the Ottawa Hospital, Ottawa, Ont. (Arnaout).

Summary: Breast-conserving surgery with adjuvant radiation therapy is widely accepted as a universal standard of care for women with early-stage breast cancer. Oncoplastic breast-conserving surgery (OPS) techniques have emerged in recent years, facilitating the achievement of better cosmetic results while adhering to good oncological principles. Compared with the rest of the international community, Canada has been fairly slow in its clinical uptake of OPS. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726963PMC
http://dx.doi.org/10.1503/cjs.001217DOI Listing
December 2017
3 Reads

New Concepts in the Treatment of Malignant Pleural Mesothelioma.

Annu Rev Med 2018 01 13;69:365-377. Epub 2017 Oct 13.

Division of General Thoracic Surgery, Michael E. DeBakey Department of General Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.

Malignant pleural mesothelioma (MPM) is a highly aggressive and generally incurable cancer. Current anti-MPM chemotherapy-based treatments are only marginally effective, and long-term survival remains an unmet goal. Nonetheless, in selected cases, personalized surgery-based multimodality treatments (MMT) have been shown to significantly extend survival. Read More

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http://dx.doi.org/10.1146/annurev-med-041316-085813DOI Listing
January 2018
9 Reads

Engineering and physical sciences in oncology: challenges and opportunities.

Nat Rev Cancer 2017 11 13;17(11):659-675. Epub 2017 Oct 13.

Department of Chemical Engineering, David H. Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. Read More

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http://dx.doi.org/10.1038/nrc.2017.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683724PMC
November 2017
132 Reads

Oncolytic Viral Therapy for Mesothelioma.

Front Oncol 2017 24;7:179. Epub 2017 Aug 24.

Hematology-Oncology-Transplant, University of Minnesota, Minneapolis, MN, United States.

The limited effectiveness of conventional therapy for malignant pleural mesothelioma demands innovative approaches to this difficult disease. Even with aggressive multimodality treatment of surgery, radiation, and/or chemotherapy, the median survival is only 1-2 years depending on stage and histology. Oncolytic viral therapy has emerged in the last several decades as a rapidly advancing field of immunotherapy studied in a wide spectrum of malignancies. Read More

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http://dx.doi.org/10.3389/fonc.2017.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573749PMC
August 2017
7 Reads

How Can We Improve Education of Breast Surgeons Across Europe?

Chirurgia (Bucur) 2017 Jul-Aug;112(4):365-366

The proposed global curriculum developed by the American Society of Surgical Oncology (SSO) and the European Society of Surgical Oncology (ESSO) and the textbook: provides a state-of- the- art of breast cancer surgery, complements the syllabus and curriculum of the Union Europeenne des Medecins Specialistes (UEMS) examination in breast surgery/ European Board of Surgery Qualification in Breast Surgery (EBSQinBS) administered by ESSO (1) Knowledge and understanding of the principles of breast cancer incidence, aetiology, risk factors, genetics, premalignant and high-risk lesions, pathology, prognostic and predictive factors, risk prediction models, screening, diagnosis and imaging, breast cancer, oncoplastic, reconstructive breast surgery, axillary surgery and future perspective for this, radiation therapy, neoadjuvant and adjuvant systemic treatment- endocrine-, immuno- and chemotherapy, side effects and toxicities of treatment, locoregional recurrence, follow-up, locally advanced breast cancer, metastatic breast cancer, breast cancer in young and elderly patients, survivor issues, lymphedema, palliative care, chroni pain, body image and sexuality, fertility issues, cognitive functions, etc.) (1) ESSO fellowships: for instance BSSO (Brazilian Society of Surgical Oncology)-ESSO fellowship, ESSO members are being offered the opportunity by the BSSO to apply for a visiting observership in Brazil; ESSO fellowship in Breast Surgery- the fellowship provides further specialised training in the multi-modality clinical care specific to the breast cancer patient and a deeper training in breast cancer research; training fellowships- to allow young surgeons to visit a specialist breast unit in Europe, to help them to expand their experience and learn new techniques; congress fellowships- for each ESSO congress the ESSO Scientific Committee awards a number of fellowship grantsto participants from low-income countries to attend the congress; EYSAC (ESSO Young Surgeons and Alumni Club) research fellowship; SSO/ ESSO fellowshipthrough its partnership with ESSO, SSO provides a grant to attend the SSO Annual Symposium; Reciprocal International Exchange Programmes with Japan, Latin America and North America (2). ESSO courses and masterclasses: expanded portfolio of courses, in- and outside Europe, basic and advanced, international faculty, multidisciplinary approach, learning methods: hands-on with human cadavers, workshops in small groups, live and case demonstrations, interactive sessions, 3D videos (for instance in 2017 ESSO course on ultrasound of breast in Barcelona, advanced course on oncoplastic surgery in Barcelona, advanced course on breast cancer surgery in Naples) (2). Read More

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http://dx.doi.org/10.21614/chirurgia.112.4.365DOI Listing
March 2018
18 Reads

Immunotherapy in Non-Small Cell Lung Cancer Treatment: Current Status and the Role of Imaging.

J Thorac Imaging 2017 Sep;32(5):300-312

Departments of *Diagnostic Radiology ‡Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX †Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.

Lung cancer remains the leading cause of cancer-related mortality and is responsible for more deaths than breast, prostate, and colon cancer combined. Most patients are diagnosed with advanced disease at the time of presentation, and treatment options have traditionally included surgery, chemotherapy, and/or radiation. However, significant advances in the molecular characterization of lung cancer have led to the creation of effective immunotherapies that assist in the recognition of cancer as foreign by the host immune system, stimulate the immune system, and relieve the inhibition that allows tumor growth and spread. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000291DOI Listing
September 2017
76 Reads