2,288 results match your criteria Radiation Oncology [Journal]


DCE and DSC perfusion MRI diagnostic accuracy in the follow-up of primary and metastatic intra-axial brain tumors treated by radiosurgery with cyberknife.

Radiat Oncol 2019 Apr 15;14(1):65. Epub 2019 Apr 15.

Neuroradiology Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Italy.

Background: The differential diagnosis between radiation necrosis, tumor recurrence and tumor progression is crucial for the evaluation of treatment response and treatment planning. The appearance of treatment-induced tissue necrosis on conventional Magnetic Resonance Imaging (MRI) is similar to brain tumor recurrence and it could be difficult to differentiate the two entities on follow-up MRI examinations. Dynamic Susceptibility Contrast-enhanced (DSC) and Dynamic Contrast-Enhanced (DCE) are MRI perfusion techniques that use an exogenous, intravascular, non-diffusible gadolinium-based contrast agent. Read More

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http://dx.doi.org/10.1186/s13014-019-1271-7DOI Listing

Neoadjuvant versus definitive chemoradiation in patients with squamous cell carcinoma of the esophagus.

Radiat Oncol 2019 Apr 16;14(1):66. Epub 2019 Apr 16.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Multimodal treatment with neoadjuvant chemoradiation followed by surgery (nCRT + S) is the treatment of choice for patients with locally advanced or node-positive esophageal squamous cell carcinoma (E-SCC). Those who are unsuitable or who decline surgery can be treated with definitive chemoradiation (dCRT). This study compares the oncologic outcome of nCRT + S and dCRT in E-SCC patients. Read More

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http://dx.doi.org/10.1186/s13014-019-1270-8DOI Listing

Impact of radiation dose on local control and survival in extramedullary head and neck plasmacytoma.

Radiat Oncol 2019 Apr 15;14(1):63. Epub 2019 Apr 15.

Department of Radiation Oncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.

Background: Patients with plasma-cell neoplasia usually suffer from systemic disease, although a minority (< 5%) may present with solitary involvement of bone or soft tissue (extramedullary plasmacytoma (EMP)). Radiotherapy (RT) is a state-of-the-art treatment for these tumors offering long term curation.

Methods And Materials: Between January 2005 and January 2017, twenty-seven patients underwent RT at our institution. Read More

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http://dx.doi.org/10.1186/s13014-019-1265-5DOI Listing

Development and characterisation of acquired radioresistant breast cancer cell lines.

Radiat Oncol 2019 Apr 15;14(1):64. Epub 2019 Apr 15.

The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, Scotland.

Background: Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation by cells that have developed radioresistance. Development of effective cancer treatments will require further molecular dissection of the processes that contribute to resistance. Read More

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http://dx.doi.org/10.1186/s13014-019-1268-2DOI Listing

Quality assurance of non-coplanar, volumetric-modulated arc therapy employing a C-arm linear accelerator, featuring continuous patient couch rotation.

Radiat Oncol 2019 Apr 11;14(1):62. Epub 2019 Apr 11.

Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Purpose: To perform quality assurance of non-coplanar, volumetric-modulated arc therapy featuring continuous couch rotation (CCR-VMAT) using a C-arm linear accelerator.

Methods: We planned and delivered CCR-VMAT using the TrueBeam Developer Mode. Treatment plans were created for both a C-shaped phantom and five prostate cancer patients using seven CCR trajectories that lacked collisions; we used RayStation software (ver. Read More

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http://dx.doi.org/10.1186/s13014-019-1264-6DOI Listing

Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy.

Radiat Oncol 2019 Apr 11;14(1):61. Epub 2019 Apr 11.

Department of Radiation Oncology, Kaohsiung Medical University Hospital, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan.

Background: This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT).

Methods: Two hundred and thirty patients with non-metastatic NPC were analyzed in terms of freedom from local failure (FFLF), freedom from distant failure (FFDF), overall survival (OS), and disease-free survival (DFS). For each patient, the status of the sinus mucosa was flexibly assessed by documenting mucosal changes as indicated by differences between images obtained before radiotherapy and more than 6 months post-radiation. Read More

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http://dx.doi.org/10.1186/s13014-019-1261-9DOI Listing
April 2019
2 Reads

Combining deep-inspiration breath hold and intensity-modulated radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma: Dosimetric evaluation using comprehensive plan quality indices.

Radiat Oncol 2019 Apr 8;14(1):59. Epub 2019 Apr 8.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Background: Although there have been many attempts to increase the therapeutic ratio of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma (MALToma), only a few planning studies have reported the efficacy of the modern radiotherapy technique till date. Therefore, we performed the dosimetric comparison among 3-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) plans, using deep-inspiration breath hold (DIBH) or free-breathing (FB) techniques, to determine the most optimal plan for gastric MALToma.

Methods: We evaluated 9 patients with gastric MALToma for whom 3D-CRT, step-and-shoot IMRT (IMRT), volumetric-modulated arc therapy (VMAT), and tomotherapy plans with identical prescribed doses were generated using DIBH or FB computed tomography (CT). Read More

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http://dx.doi.org/10.1186/s13014-019-1263-7DOI Listing
April 2019
1 Read

Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage.

Radiat Oncol 2019 Apr 8;14(1):58. Epub 2019 Apr 8.

Cell Oncology, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.

Doxycycline (DXC) is a tetracycline antibiotic which has been proposed as a breast cancer radiosensitizer by specifically reducing the expression of the DNA repair enzyme DNA PK in breast cancer initiating cells. Since DXC presents favorable pharmacokinetics properties including the capacity to cross the blood-brain barrier, it has been hypothesized that it could radiosensitize brain tumors as well. We have investigated the radiosensitizing capacity of DXC towards human glioma initiating cells (GIC)-driven orthotopic glioblastomas (GB) in NOD/SCID mice that faithfully mimic the growth properties of the clinical tumors of origin. Read More

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http://dx.doi.org/10.1186/s13014-019-1266-4DOI Listing

A systematic review of dose-volume predictors and constraints for late bowel toxicity following pelvic radiotherapy.

Radiat Oncol 2019 Apr 3;14(1):57. Epub 2019 Apr 3.

Department of Clinical Oncology, Velindre Cancer Centre, Velindre Road, Whitchurch, Cardiff, CF14 2TL, UK.

Background: Advanced pelvic radiotherapy techniques aim to reduce late bowel toxicity which can severely impact the lives of pelvic cancer survivors. Although advanced techniques have been largely adopted worldwide, to achieve their aim, knowledge of which dose-volume parameters of which components of bowel predict late bowel toxicity is crucial to make best use of these techniques. The rectum is an extensively studied organ at risk (OAR), and dose-volume predictors of late toxicity for the rectum are established. Read More

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http://dx.doi.org/10.1186/s13014-019-1262-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448293PMC

Evaluation of optimal treatment planning for radiotherapy of synchronous bilateral breast cancer including regional lymph node irradiation.

Radiat Oncol 2019 Apr 1;14(1):56. Epub 2019 Apr 1.

Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Korea.

Background: We evaluated the optimal radiotherapy (RT) plan for synchronous bilateral breast cancer (SBBC), especially treatment plans including the regional lymph node (LN) area.

Methods: This study was conducted using 15 patients with SBBC (5 with small breasts, 5 with large breasts, and 5 who underwent a left total mastectomy). The clinical target volume (CTV) was defined as the volume enveloping the bilateral whole breasts/chest wall and left regional LN area. Read More

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http://dx.doi.org/10.1186/s13014-019-1257-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444509PMC
April 2019
2 Reads

Comparative efficacy and safety for different chemotherapy regimens used concurrently with thoracic radiation for locally advanced non-small cell lung cancer: a systematic review and network meta-analysis.

Radiat Oncol 2019 Mar 29;14(1):55. Epub 2019 Mar 29.

Department of Radiation Oncology, The First Hospital of China Medical University, 155 Nanjing Road, Heping District, Shenyang, 110001, China.

Background: It remains unknown which is the most preferable regimen used concurrently with thoracic radiation for locally advanced non-small cell lung cancer (NSCLC). We performed a network meta-analysis to address this important issue.

Methods: PubMed, Embase, Cochrane Library, Web of Science and major international scientific meetings were searched for relevant randomized controlled trials (RCTs). Read More

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http://dx.doi.org/10.1186/s13014-019-1239-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441209PMC
March 2019
2 Reads

Proposed revision of the 8th edition AJCC clinical staging system for esophageal squamous cell cancer treated with definitive chemo-IMRT based on CT imaging.

Radiat Oncol 2019 Mar 28;14(1):54. Epub 2019 Mar 28.

Fujian Provincial Platform for Medical Laboratory Research of First Affiliated Hospital, Fuzhou, Fujian, People's Republic of China.

Purpose: To validate and propose revision of the 8th edition American Joint Committee on Cancer (AJCC) clinical staging system for esophageal squamous cell cancer (ESCC) patients treated with definitive intensity-modulated radiation therapy combined with concurrent chemotherapy (Chemo-IMRT) based on computed tomography (CT) imaging.

Methods: The clinical data of patients with ESCC treated with Chemo-IMRT were collected and retrospectively reviewed. All CT images were independently reevaluated and restaged according to the 8th edition AJCC staging system. Read More

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http://dx.doi.org/10.1186/s13014-019-1258-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437982PMC

Albumin - bilirubin (ALBI) versus Child-Turcotte-Pugh (CTP) in prognosis of HCC after stereotactic body radiation therapy.

Radiat Oncol 2019 Mar 27;14(1):50. Epub 2019 Mar 27.

Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530001, Guangxi Zhuang Autonomous Region, China.

Background: Child-Turcotte-Pugh (CTP) score extensively used to assess hepatic function, predicting postoperative outcome of hepatocellular carcinoma (HCC) patients. Lately, the albumin-bilirubin (ALBI) grade has been identified to be a predictor of overall survival of HCC patients. In this investigation, we compared the pre-SBRT ALBI and CTP scores with the prognosis of patients with HCC. Read More

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http://dx.doi.org/10.1186/s13014-019-1251-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436219PMC

Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era.

Radiat Oncol 2019 Mar 27;14(1):51. Epub 2019 Mar 27.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Immunotherapy is currently being examined as a treatment modality for glioblastoma. Maintaining an optimal total lymphocyte count (TLC) after radiotherapy (RT) and using temozolomide may be beneficial in optimizing immunotherapy. However, conventional temozolomide-based chemoradiation is known to induce immunosuppressive effects, including lymphopenia. Read More

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http://dx.doi.org/10.1186/s13014-019-1256-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436232PMC

Strategy to avoid local recurrence in patients with locally advanced rectal cancer.

Radiat Oncol 2019 Mar 27;14(1):53. Epub 2019 Mar 27.

Department of Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan.

Background: To clarify the short- and long-term outcomes of radical surgery after neoadjuvant chemoradiotherapy (NCRT) with TS-1 and irinotecan, which enhances radiosensitivity, in patients with locally advanced rectal cancer.

Methods: The study group comprised 105 patients with locally advanced rectal cancer who received NCRT followed by radical surgery. NCRT consisted of pelvic radiotherapy (45 Gy in 25 fractions over a period of 5 weeks), S-1 (80 mg/m) given concurrently for 25 days, and irinotecan (60 mg/m), given once a week as a continuous intravenous infusion. Read More

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http://dx.doi.org/10.1186/s13014-019-1253-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438014PMC

Comparisons of different neoadjuvant chemotherapy regimens with or without stereotactic body radiation therapy for borderline resectable pancreatic cancer: study protocol of a prospective, randomized phase II trial (BRPCNCC-1).

Radiat Oncol 2019 Mar 27;14(1):52. Epub 2019 Mar 27.

Department of Surgery, Changhai Hospital Affiliated to Navy Medical University, 168 Changhai Road, Shanghai, 200433, China.

Background: Few patients with pancreatic cancer may be candidates for immediate surgical resection at the initial diagnosis. Even if patients with borderline resectable pancreatic cancer (BRPC), micrometastases may occur before surgery. Therefore, neoadjuvant therapy is vital for improved survival, which has been confirmed in previous studies that neoadjuvant chemotherapy with or without radiotherapy provides superior overall compared with upfront surgery. Read More

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http://dx.doi.org/10.1186/s13014-019-1254-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437889PMC
March 2019
1 Read

Dose-volume relationship for laryngeal substructures and aspiration in patients with locally advanced head-and-neck cancer.

Radiat Oncol 2019 Mar 18;14(1):49. Epub 2019 Mar 18.

Department of Radiation Oncology, Northwestern University, Chicago, IL, USA.

Background: Literature has shown a significant relationship between radiation dose to the larynx and swallowing disorders. We prospectively studied the dose-volume relationship for larynx substructures and aspiration.

Methods: Forty nine patients with stage III/IV head-and-neck (H&N) squamous cell carcinoma were prospectively enrolled in this IRB-approved, federally funded study. Read More

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http://dx.doi.org/10.1186/s13014-019-1247-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423881PMC
March 2019
1 Read

Dosimetric evaluation of four whole brain radiation therapy approaches with hippocampus and inner ear avoidance and simultaneous integrated boost for limited brain metastases.

Radiat Oncol 2019 Mar 15;14(1):46. Epub 2019 Mar 15.

Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, 440 Jiyan Road, Jinan, 250117, Shandong, China.

Aims: To perform a dosimetric evaluation of four different simultaneous integrated boost whole brain radiotherapy modalities with hippocampus and inner ear avoidance in the treatment of limited brain metastases.

Methods: Computed tomography/magnetic resonance imaging data of 10 patients with limited (1-5) brain metastases were used to replan step-and-shoot intensity-modulated radiotherapy (sIMRT), dynamic intensity-modulated radiation therapy (dIMRT), volumetric-modulated arc therapy (VMAT), and helical tomotherapy (Tomo). The prescribed doses of 40-50 Gy in 10 fractions and 30 Gy in 10 fractions were simultaneously delivered to the metastatic lesions and the whole-brain volume, respectively. Read More

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http://dx.doi.org/10.1186/s13014-019-1255-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419811PMC

A phase I/II radiation dose escalation trial using simultaneous integrated boost technique with elective nodal irradiation and concurrent chemotherapy for unresectable esophageal Cancer.

Radiat Oncol 2019 Mar 15;14(1):48. Epub 2019 Mar 15.

Department of Radiation Oncology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 Panjiayuan Nanli, Beijing, 100021, China.

Background: To investigate the safety and tolerability of simultaneous integrated boost (SIB) technique concurrent with elective nodal irradiation (ENI) and dual-drug chemotherapy for patients with unresectable esophageal cancer.

Methods: In phase I, the prophylactic PTV received a stable dose of 50.40Gy/1. Read More

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http://dx.doi.org/10.1186/s13014-019-1249-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420772PMC
March 2019
3 Reads
2.546 Impact Factor

Rectum-spacer related acute toxicity - endoscopy results of 403 prostate cancer patients after implantation of gel or balloon spacers.

Radiat Oncol 2019 Mar 15;14(1):47. Epub 2019 Mar 15.

Dapartment of Radiotherapy and Radio-Oncology, LKH Salzburg University Clinics, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, Austria.

Background: Rectal spacers are used to limit dose to the anterior rectal wall in high dose external beam radiation therapy of the prostate and have been shown to reduce radiation induced toxicity. Here we report the complication rate and toxicity of the implantation procedure in a large cohort of patients who have either received a gel- or balloon-type spacer.

Methods: In total, 403 patients received rectal spacing, 264 with balloon, 139 with gel. Read More

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http://dx.doi.org/10.1186/s13014-019-1248-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419822PMC
March 2019
1 Read

Impact of regular magnetic resonance imaging follow-up after stereotactic radiotherapy to the surgical cavity in patients with one to three brain metastases.

Radiat Oncol 2019 Mar 14;14(1):45. Epub 2019 Mar 14.

Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 18, CH-3010, Bern, Switzerland.

Background: Administering stereotactic radiotherapy to the surgical cavity and thus omitting postoperative whole brain radiotherapy (WBRT) is a favored strategy in limited metastatic brain disease. Little is known about the impact of regular magnetic resonance imaging follow-up (MRI FU) in such patient cohorts. The aim of this study is to examine the impact of regular MRI FU and to report the oncological outcomes of patients with one to three brain metastases (BMs) treated with stereotactic radiosurgery (SRS) or hypo-fractionated stereotactic radiotherapy (HFSRT) to the surgical cavity. Read More

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http://dx.doi.org/10.1186/s13014-019-1252-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417038PMC
March 2019
1 Read

Optimal timing and clinical value of radiotherapy in advanced ALK-rearranged non-small cell lung cancer with or without baseline brain metastases: implications from pattern of failure analyses.

Radiat Oncol 2019 Mar 13;14(1):44. Epub 2019 Mar 13.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China.

Background: Despite development of several next-generation tyrosine kinase inhibitors (TKIs), crizotinib remains one of the first-line treatment options for advanced ALK-positive NSCLC and is widely used in situations where next-generation TKIs aren't yet approved or economically inaccessible. However, the pattern of failure and clinical value of radiotherapy in metastatic crizotinib-treated ALK-mutant lung cancer, with or without baseline brain metastases (BBM), are largely unknown.

Methods: Consecutive crizotinib-treated NSCLC patients with adequate imaging and measurable disease were retrospectively enrolled. Read More

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http://dx.doi.org/10.1186/s13014-019-1240-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417092PMC
March 2019
4 Reads
2.546 Impact Factor

Risk factors to identify patients who may not benefit from whole brain irradiation for brain metastases - a single institution analysis.

Radiat Oncol 2019 Mar 11;14(1):41. Epub 2019 Mar 11.

Department of Radiotherapy, General Hospital of Lippe, GmbH Rintelner Straße 85 |, Lemgo, Lippe, Germany.

Background: Radiotherapy plays a major role in the management of brain metastases. This study aimed to identify the subset of patients with multiple brain metastases who may not benefit from whole brain irradiation (WBI) due to a short survival time regardless of treatment.

Methods: We analyzed a total of 339 patient records with brain metastases treated with whole brain radiotherapy from January 2009 to January 2016. Read More

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http://dx.doi.org/10.1186/s13014-019-1245-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417259PMC
March 2019
2 Reads

Delta-radiomics signature predicts treatment outcomes after preoperative chemoradiotherapy and surgery in rectal cancer.

Radiat Oncol 2019 Mar 12;14(1):43. Epub 2019 Mar 12.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam, 13620, Republic of Korea.

Background: To develop and compare delta-radiomics signatures from 2- (2D) and 3-dimensional (3D) features that predict treatment outcomes following preoperative chemoradiotherapy (CCRT) and surgery for locally advanced rectal cancer.

Methods: In total, 101 patients (training cohort, n = 67; validation cohort, n = 34) with locally advanced rectal adenocarcinoma between 2008 and 2015 were included. We extracted 55 features from T2-weighted magnetic resonance imaging (MRI) scans. Read More

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http://dx.doi.org/10.1186/s13014-019-1246-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417065PMC

Development and validation of a model for temporal lobe necrosis for nasopharyngeal carcinoma patients with intensity modulated radiation therapy.

Radiat Oncol 2019 Mar 12;14(1):42. Epub 2019 Mar 12.

Department of radiation oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: To develop and validate a quantitative complication model of temporal lobe necrosis (TLN). To analyze the effect of clinical and dosimetric factors on TLN.

Patients And Methods: In this study the prediction model was developed in a training cohort that consisted of 256 nasopharyngeal carcinoma (NPC) patients from January 2009 to December 2009. Read More

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http://dx.doi.org/10.1186/s13014-019-1250-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416868PMC
March 2019
1 Read

Frequency and risk factors for arm lymphedema after multimodal breast-conserving treatment of nodal positive breast Cancer - a long-term observation.

Radiat Oncol 2019 Mar 7;14(1):39. Epub 2019 Mar 7.

Department of Radiation Oncology, Hannover Medical School (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

Background: Arm-lymphedema is a major complication after breast cancer. Recent studies demonstrate the validity of predicting Breast Cancer Related Lymphedema (BCRL) by self-reports. We aimed to investigate the rate of BCRL and its risk factors in the long-term using self-reported symptoms. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1243-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407279PMC
March 2019
6 Reads

The relationship between radiation doses to coronary arteries and location of coronary stenosis requiring intervention in breast cancer survivors.

Radiat Oncol 2019 Mar 7;14(1):40. Epub 2019 Mar 7.

Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, Uppsala University, University Hospital, SE-751 85, Uppsala, Sweden.

Background: To assess the relationship between radiation doses to the coronary arteries (CAs) and location of a coronary stenosis that required intervention after three-dimensional conformal radiotherapy (3DCRT) for breast cancer (BC).

Methods: The study population consisted of 182 women treated for BC in Sweden between 1992 and 2012. All women received 3DCRT and subsequently underwent coronary angiography due to a suspected coronary event. Read More

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http://dx.doi.org/10.1186/s13014-019-1242-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407212PMC
March 2019
1 Read

A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging.

Radiat Oncol 2019 Mar 5;14(1):38. Epub 2019 Mar 5.

Department of Medical Imaging, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong province, China.

Background: To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation imaging based on deformable image registration (DIR) for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS).

Methods: Eighteen breast cancer patients suitable for EB-PBI were enrolled. Preoperative prone diagnostic MRI and postoperative prone CT scan sets for all the patients were acquired during free breathing. Read More

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http://dx.doi.org/10.1186/s13014-019-1244-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402104PMC
March 2019
2 Reads
2.546 Impact Factor

Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme.

Radiat Oncol 2019 Mar 4;14(1):37. Epub 2019 Mar 4.

Department of Oncology, Radiotherapy and Gynecologic Oncology, Faculty of Health Sciences, Nicolaus Copernicus University Toruń, Bydgoszcz, Poland.

Background: Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective alternative to dynamic FET PET, but its prognostic value, particularly with respect to SVZ involvement, is unknown.

Methods: Thirty-five patients had two scans 5-15 and 50-60 min after i. Read More

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http://dx.doi.org/10.1186/s13014-019-1241-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398237PMC
March 2019
3 Reads

Comparison of gamma index based on dosimetric error and clinically relevant dose-volume index based on three-dimensional dose prediction in breast intensity-modulated radiation therapy.

Radiat Oncol 2019 Feb 26;14(1):36. Epub 2019 Feb 26.

Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan.

Background: Measurement-guided dose reconstruction has lately attracted significant attention because it can predict the delivered patient dose distribution. Although the treatment planning system (TPS) uses sophisticated algorithm to calculate the dose distribution, the calculation accuracy depends on the particular TPS used. This study aimed to investigate the relationship between the gamma passing rate (GPR) and the clinically relevant dose-volume index based on the predicted 3D patient dose distribution derived from two TPSs (XiO, RayStation). Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1233-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390354PMC
February 2019
3 Reads

Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience.

Radiat Oncol 2019 Feb 19;14(1):34. Epub 2019 Feb 19.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1238-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381740PMC
February 2019
4 Reads

Metabolic parameters of sequential 18F-FDG PET/CT predict overall survival of esophageal cancer patients treated with (chemo-) radiation.

Radiat Oncol 2019 Feb 19;14(1):35. Epub 2019 Feb 19.

Department of Nuclear Medicine, Xiamen Cancer Hospital, the First Affiliated Hospital of Xiamen University/Southern Fujian PET Center, Xiamen, China.

Background: To evaluate the prognostic value of metabolic parameters of pre-treatment and interim 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for overall survival (OS) of esophageal cancer(EC) patients undergoing (chemo-) radiotherapy.

Methods: A retrospective analysis of 134 patients with pathology confirmed squamous cell EC treated between July 2009 and October 2013 in our hospital was performed. Inclusion criteria for this study were curative intended radiotherapy and availability of pre-treatment and interim 18F-FDG PET. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1236-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381652PMC
February 2019
3 Reads

Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous.

Radiat Oncol 2019 Feb 15;14(1):33. Epub 2019 Feb 15.

Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA.

Background: Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ trial now influence the decision to recommend or withhold WBRT for patients with unfavorable prognosis, and similarly, for favorable prognosis patients, the balance between radiosurgery alone or WBRT has become a nuanced decision. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1237-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377775PMC
February 2019
7 Reads
2.546 Impact Factor

3-weekly or weekly cisplatin concurrently with radiotherapy for patients with squamous cell carcinoma of the head and neck - a multicentre, retrospective analysis.

Radiat Oncol 2019 Feb 11;14(1):32. Epub 2019 Feb 11.

Department Internal Medicine, University Hospital Basel, Medical Oncology, Petersgraben 4, 4031, Basel, Switzerland.

Background: Concurrent chemoradiotherapy with cisplatin is standard for patients (pts) with loco-regionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) and for patients with resected SCCHN with high-risk features. The standard regimen includes 3-weekly cisplatin, but weekly regimens are often used to lower toxicity. Reaching a cumulative dose of ≥200 mg/m cisplatin was shown being associated with improved outcome. Read More

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http://dx.doi.org/10.1186/s13014-019-1235-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371614PMC
February 2019
5 Reads

Dosimetric predictors of temporal lobe injury after intensity-modulated radiotherapy for T4 nasopharyngeal carcinoma: a competing risk study.

Radiat Oncol 2019 Feb 8;14(1):31. Epub 2019 Feb 8.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: In patients with T4 nasopharyngeal carcinoma (NPC), death may occur prior to the occurrence of temporal lobe injury (TLI). Because such competing risk death precludes the occurrence of TLI and thus the competing risk analysis should be applied to TLI research. The aim was to investigate the incidence and predictive factors of TLI after intensity-modulated radiotherapy (IMRT) among T4 NPC patients. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1229-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368802PMC
February 2019
10 Reads

4DMRI-based investigation on the interplay effect for pencil beam scanning proton therapy of pancreatic cancer patients.

Radiat Oncol 2019 Feb 7;14(1):30. Epub 2019 Feb 7.

Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Background: Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional imaging dose. We use 4DMRI to investigate the interplay effect for pencil beam scanning (PBS) proton therapy of pancreatic cancer and to quantify the dependency of residual interplay effects on the number of treatment fractions.

Methods: Based on repeated 4DMRI datasets for nine pancreatic cancer patients, synthetic 4DCTs were generated by warping static 3DCTs with 4DMRI deformation vector fields. Read More

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http://dx.doi.org/10.1186/s13014-019-1231-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367829PMC
February 2019
6 Reads

Is mean heart dose a relevant surrogate parameter of left ventricle and coronary arteries exposure during breast cancer radiotherapy: a dosimetric evaluation based on individually-determined radiation dose (BACCARAT study).

Radiat Oncol 2019 Feb 7;14(1):29. Epub 2019 Feb 7.

Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-HOM/SDOS/LEDI, Fontenay-aux-Roses, France.

Background: Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered in previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosimetric study analyzes the distribution of individually-determined radiation doses to the heart and its substructures including coronary arteries and evaluate whether MHD is a relevant surrogate parameter of dose for these substructures.

Methods: Data were collected from the BACCARAT prospective study that included left or right unilateral BC patients treated with 3D-Conformal Radiotherapy (RT) between 2015 and 2017 and followed-up for 2 years with repeated cardiac imaging examinations. Read More

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http://dx.doi.org/10.1186/s13014-019-1234-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367844PMC
February 2019
3 Reads

Radiological diagnosis of brain radiation necrosis after cranial irradiation for brain tumor: a systematic review.

Radiat Oncol 2019 Feb 6;14(1):28. Epub 2019 Feb 6.

Department of Neurosurgery, Osaka Medical College, 2-7, Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.

Introduction: This systematic review aims to elucidate the diagnostic accuracy of radiological examinations to distinguish between brain radiation necrosis (BRN) and tumor progression (TP).

Methods: We divided diagnostic approaches into two categories as follows-conventional radiological imaging [computed tomography (CT) and magnetic resonance imaging (MRI): review question (RQ) 1] and nuclear medicine studies [single photon emission CT (SPECT) and positron emission tomography (PET): RQ2]-and queried. Our librarians conducted a comprehensive systematic search on PubMed, the Cochrane Library, and the Japan Medical Abstracts Society up to March 2015. Read More

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http://dx.doi.org/10.1186/s13014-019-1228-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364413PMC
February 2019
2 Reads

Driving developments in UK oesophageal radiotherapy through the SCOPE trials.

Radiat Oncol 2019 Feb 4;14(1):26. Epub 2019 Feb 4.

Velindre Cancer Centre, Cardiff, UK.

Background: The SCOPE trials (SCOPE 1, NeoSCOPE and SCOPE 2) have been the backbone of oesophageal RT trials in the UK. Many changes in oesophageal RT techniques have taken place in this time. The SCOPE trials have, in addition to adopting these new techniques, been influential in aiding centres with their implementation. Read More

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http://dx.doi.org/10.1186/s13014-019-1225-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360789PMC
February 2019

Prognostic values of mid-radiotherapy F-FDG PET/CT in patients with esophageal cancer.

Radiat Oncol 2019 Feb 4;14(1):27. Epub 2019 Feb 4.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: To identify whether early metabolic responses as determined using F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) during radiotherapy (RT) predict outcomes in patients with esophageal cancer.

Methods: Twenty-one patients with esophageal cancer who received pre-treatment F-FDG PET/CT (PET1) and inter-fractional F-FDG PET/CT (PET2) after 11 fractions of RT (median 23.1 Gy, 2. Read More

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http://dx.doi.org/10.1186/s13014-019-1232-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362604PMC
February 2019

The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition.

Radiat Oncol 2019 Feb 4;14(1):25. Epub 2019 Feb 4.

Department of Radiotherapy and Radio-Oncology, Universitätsklinikum Marien Hospital Herne, Ruhr-Universität Bochum, Herne, Germany.

Background: Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might influence the metastatic process. Read More

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http://dx.doi.org/10.1186/s13014-019-1230-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360706PMC
February 2019

A step towards international prospective trials in carbon ion radiotherapy: investigation of factors influencing dose distribution in the facilities in operation based on a case of skull base chordoma.

Radiat Oncol 2019 Feb 1;14(1):24. Epub 2019 Feb 1.

Service de Cancérologie-Radiothérapie, Hôpital A.Michallon, CHU de Grenoble, Grenoble, France.

Background: Carbon ion radiotherapy (CIRT) has been delivered to more than 20,000 patients worldwide. International trials have been recommended in order to emphasize the actual benefits. The ULICE program (Union of Light Ion Centers in Europe) addressed the need for harmonization of CIRT practices. Read More

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http://dx.doi.org/10.1186/s13014-019-1224-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359776PMC
February 2019
3 Reads

Leukotoxicity after moderately Hypofractionated radiotherapy versus conventionally fractionated dose escalated radiotherapy for localized prostate Cancer: a secondary analysis from a randomized study.

Radiat Oncol 2019 Jan 30;14(1):23. Epub 2019 Jan 30.

Department of Radiation Oncology, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

Background: To compare WBC counts during treatment of localized prostate cancer with either conventionally fractionated (CF) or moderately hypofractionated (HYPO) radiotherapy.

Methods: Weekly blood test results were extracted from the charts of patients treated within a phase III study comparing HYPO to CF. In order to compare WBC counts at the same nominal dose in both arms and thus to tease out the effect of fractionation, for each recorded WBC value the corresponding cumulative total dose was extracted as well. Read More

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http://dx.doi.org/10.1186/s13014-019-1223-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352380PMC
January 2019
1 Read

Analyses of the factors influencing the accuracy of three-dimensional ultrasound in comparison with cone-beam CT in image-guided radiotherapy for prostate cancer with or without pelvic lymph node irradiation.

Radiat Oncol 2019 Jan 29;14(1):22. Epub 2019 Jan 29.

Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, No. 651, Dongfeng Road East, Guangzhou, 510060, China.

Background: Three-dimensional ultrasound (3DUS) is an attractive option in image-guided radiotherapy (IGRT) for prostate cancer (PCa) patients. However, the potential factors influencing the accuracy of 3DUS in comparison with cone-beam CT (CBCT) in IGRT for PCa patients haven't been clearly identified.

Methods: The differences between US/US and CBCT/CT registrations were analyzed over 586 and 580 sessions for 24 and 25 PCa patients treated with or without pelvic lymph node irradiation, respectively. Read More

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http://dx.doi.org/10.1186/s13014-019-1217-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352439PMC
January 2019
5 Reads

Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects.

Radiat Oncol 2019 Jan 29;14(1):21. Epub 2019 Jan 29.

Medical University of Graz, Diagnostic and Research Institute of Pathology, Neue Stiftingtalstrasse 6, 8036, Graz, Austria.

Background: Despite the advances in oncology, patients with bulky tumors have worse prognosis and often receive only palliative treatments. Bulky disease represents an important challenging obstacle for all currently available radical treatment options including conventional radiotherapy. The purpose of this study was to assess a retrospective outcome on the use of a newly developed unconventional stereotactic body radiation therapy (SBRT) for PArtial Tumor irradiation of unresectable bulky tumors targeting exclusively their HYpoxic segment (SBRT-PATHY) that exploits the non-targeted effects of radiotherapy: bystander effects (local) and the abscopal effects (distant). Read More

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http://dx.doi.org/10.1186/s13014-019-1227-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352381PMC
January 2019
1 Read

Role of postoperative radiotherapy in dermatofibrosarcoma protuberans: a propensity score-matched analysis.

Radiat Oncol 2019 Jan 29;14(1):20. Epub 2019 Jan 29.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, 350014, China.

Objective: This study aimed to evaluate the role of postoperative radiotherapy (RT) in dermatofibrosarcoma protuberans (DFSP) and identify the prognostic factors influencing the disease-free survival (DFS).

Methods: A total of 184 patients with DFSP were analyzed from 2000 to 2016. The regression model was used to examine the prognostic factors for DFS. Read More

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http://dx.doi.org/10.1186/s13014-019-1226-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350344PMC
January 2019
2 Reads

Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: comparison between X-ray and proton therapy.

Radiat Oncol 2019 Jan 28;14(1):19. Epub 2019 Jan 28.

Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Idiopathic pulmonary fibrosis (IPF) is associated with fatal complications after radiotherapy (RT) for lung cancer patients; however, the role of proton therapy to reduce the incidence of life-threatening complications is unclear. Herein, we present the preliminary results of early-stage lung cancer patients having IPF and treated with RT, with a focus on the comparison between X-ray and proton therapy.

Methods: From January 2010 to October 2017, we retrospectively reviewed the medical records of 264 patients with stage I-II non-small cell lung cancer (NSCLC) treated with definitive RT alone. Read More

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http://dx.doi.org/10.1186/s13014-019-1221-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348683PMC
January 2019
2 Reads

Overall survival according to immunotherapy and radiation treatment for metastatic non-small-cell lung cancer: a National Cancer Database analysis.

Radiat Oncol 2019 Jan 28;14(1):18. Epub 2019 Jan 28.

Department of Radiation and Cellular Oncology, The University of Chicago Medicine, 5758 S. Maryland Avenue, MC 9006, Chicago, IL, 60637, USA.

Background: Preclinical studies suggest enhanced anti-tumor activity with combined radioimmunotherapy. We hypothesized that radiation (RT) + immunotherapy would associate with improved overall survival (OS) compared to immunotherapy or chemotherapy alone for patients with newly diagnosed metastatic non-small-cell lung cancer (NSCLC).

Methods: The National Cancer Database was queried for patients with stage IV NSCLC receiving chemotherapy or immunotherapy from 2013 to 2014. Read More

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http://dx.doi.org/10.1186/s13014-019-1222-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348608PMC
January 2019
2 Reads

Simultaneous integrated boost with helical arc radiotherapy of total skin (HEARTS) to treat cutaneous manifestations of advanced, therapy-refractory cutaneous lymphoma and leukemia - dosimetry comparison of different regimens and clinical application.

Radiat Oncol 2019 Jan 28;14(1):17. Epub 2019 Jan 28.

School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: Helical irradiation of the total skin (HITS) was modified as simultaneous integrated boost (SIB)-helical arc radiotherapy of total skin (HEARTS) technique and applied to an acute myeloid leukemia (AML) patient with disseminated leukemia cutis.

Methods: The original HITS plan was revised for different regimens, i.e. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1220-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348688PMC
January 2019
4 Reads

Early stage non-small cell lung cancer treated with pencil beam scanning particle therapy: retrospective analysis of early results on safety and efficacy.

Radiat Oncol 2019 Jan 25;14(1):16. Epub 2019 Jan 25.

Department of Radiation Oncology, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Fudan University, Shanghai, China.

Background: To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC).

Methods: From 08/2014 to 03/2018, 31 consecutive patients with sum of the longest diameters of primary tumor and hilar lymph node < 5 cm, N0-1, M0 NSCLC treated with PT were retrospectively analyzed. Gating/active breathing control techniques were used to control tumor motion in 20 and 7 patients. Read More

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http://dx.doi.org/10.1186/s13014-019-1216-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347845PMC
January 2019
5 Reads