2,256 results match your criteria Radiation Oncology [Journal]


Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous.

Radiat Oncol 2019 Feb 15;14(1):33. Epub 2019 Feb 15.

Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA.

Background: Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ trial now influence the decision to recommend or withhold WBRT for patients with unfavorable prognosis, and similarly, for favorable prognosis patients, the balance between radiosurgery alone or WBRT has become a nuanced decision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1237-9DOI Listing
February 2019

3-weekly or weekly cisplatin concurrently with radiotherapy for patients with squamous cell carcinoma of the head and neck - a multicentre, retrospective analysis.

Radiat Oncol 2019 Feb 11;14(1):32. Epub 2019 Feb 11.

Department Internal Medicine, University Hospital Basel, Medical Oncology, Petersgraben 4, 4031, Basel, Switzerland.

Background: Concurrent chemoradiotherapy with cisplatin is standard for patients (pts) with loco-regionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) and for patients with resected SCCHN with high-risk features. The standard regimen includes 3-weekly cisplatin, but weekly regimens are often used to lower toxicity. Reaching a cumulative dose of ≥200 mg/m cisplatin was shown being associated with improved outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1235-yDOI Listing
February 2019
2 Reads

Dosimetric predictors of temporal lobe injury after intensity-modulated radiotherapy for T4 nasopharyngeal carcinoma: a competing risk study.

Radiat Oncol 2019 Feb 8;14(1):31. Epub 2019 Feb 8.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: In patients with T4 nasopharyngeal carcinoma (NPC), death may occur prior to the occurrence of temporal lobe injury (TLI). Because such competing risk death precludes the occurrence of TLI and thus the competing risk analysis should be applied to TLI research. The aim was to investigate the incidence and predictive factors of TLI after intensity-modulated radiotherapy (IMRT) among T4 NPC patients. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1229-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368802PMC
February 2019
1 Read

4DMRI-based investigation on the interplay effect for pencil beam scanning proton therapy of pancreatic cancer patients.

Radiat Oncol 2019 Feb 7;14(1):30. Epub 2019 Feb 7.

Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Background: Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional imaging dose. We use 4DMRI to investigate the interplay effect for pencil beam scanning (PBS) proton therapy of pancreatic cancer and to quantify the dependency of residual interplay effects on the number of treatment fractions.

Methods: Based on repeated 4DMRI datasets for nine pancreatic cancer patients, synthetic 4DCTs were generated by warping static 3DCTs with 4DMRI deformation vector fields. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1231-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367829PMC
February 2019

Is mean heart dose a relevant surrogate parameter of left ventricle and coronary arteries exposure during breast cancer radiotherapy: a dosimetric evaluation based on individually-determined radiation dose (BACCARAT study).

Radiat Oncol 2019 Feb 7;14(1):29. Epub 2019 Feb 7.

Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-HOM/SDOS/LEDI, Fontenay-aux-Roses, France.

Background: Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered in previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosimetric study analyzes the distribution of individually-determined radiation doses to the heart and its substructures including coronary arteries and evaluate whether MHD is a relevant surrogate parameter of dose for these substructures.

Methods: Data were collected from the BACCARAT prospective study that included left or right unilateral BC patients treated with 3D-Conformal Radiotherapy (RT) between 2015 and 2017 and followed-up for 2 years with repeated cardiac imaging examinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1234-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367844PMC
February 2019
1 Read

Radiological diagnosis of brain radiation necrosis after cranial irradiation for brain tumor: a systematic review.

Radiat Oncol 2019 Feb 6;14(1):28. Epub 2019 Feb 6.

Department of Neurosurgery, Osaka Medical College, 2-7, Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.

Introduction: This systematic review aims to elucidate the diagnostic accuracy of radiological examinations to distinguish between brain radiation necrosis (BRN) and tumor progression (TP).

Methods: We divided diagnostic approaches into two categories as follows-conventional radiological imaging [computed tomography (CT) and magnetic resonance imaging (MRI): review question (RQ) 1] and nuclear medicine studies [single photon emission CT (SPECT) and positron emission tomography (PET): RQ2]-and queried. Our librarians conducted a comprehensive systematic search on PubMed, the Cochrane Library, and the Japan Medical Abstracts Society up to March 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1228-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364413PMC
February 2019
1 Read

Driving developments in UK oesophageal radiotherapy through the SCOPE trials.

Radiat Oncol 2019 Feb 4;14(1):26. Epub 2019 Feb 4.

Velindre Cancer Centre, Cardiff, UK.

Background: The SCOPE trials (SCOPE 1, NeoSCOPE and SCOPE 2) have been the backbone of oesophageal RT trials in the UK. Many changes in oesophageal RT techniques have taken place in this time. The SCOPE trials have, in addition to adopting these new techniques, been influential in aiding centres with their implementation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1225-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360789PMC
February 2019

Prognostic values of mid-radiotherapy F-FDG PET/CT in patients with esophageal cancer.

Radiat Oncol 2019 Feb 4;14(1):27. Epub 2019 Feb 4.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: To identify whether early metabolic responses as determined using F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) during radiotherapy (RT) predict outcomes in patients with esophageal cancer.

Methods: Twenty-one patients with esophageal cancer who received pre-treatment F-FDG PET/CT (PET1) and inter-fractional F-FDG PET/CT (PET2) after 11 fractions of RT (median 23.1 Gy, 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1232-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362604PMC
February 2019

The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition.

Radiat Oncol 2019 Feb 4;14(1):25. Epub 2019 Feb 4.

Department of Radiotherapy and Radio-Oncology, Universitätsklinikum Marien Hospital Herne, Ruhr-Universität Bochum, Herne, Germany.

Background: Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might influence the metastatic process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1230-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360706PMC
February 2019

A step towards international prospective trials in carbon ion radiotherapy: investigation of factors influencing dose distribution in the facilities in operation based on a case of skull base chordoma.

Radiat Oncol 2019 Feb 1;14(1):24. Epub 2019 Feb 1.

Service de Cancérologie-Radiothérapie, Hôpital A.Michallon, CHU de Grenoble, Grenoble, France.

Background: Carbon ion radiotherapy (CIRT) has been delivered to more than 20,000 patients worldwide. International trials have been recommended in order to emphasize the actual benefits. The ULICE program (Union of Light Ion Centers in Europe) addressed the need for harmonization of CIRT practices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1224-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359776PMC
February 2019
2 Reads

Leukotoxicity after moderately Hypofractionated radiotherapy versus conventionally fractionated dose escalated radiotherapy for localized prostate Cancer: a secondary analysis from a randomized study.

Radiat Oncol 2019 Jan 30;14(1):23. Epub 2019 Jan 30.

Department of Radiation Oncology, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

Background: To compare WBC counts during treatment of localized prostate cancer with either conventionally fractionated (CF) or moderately hypofractionated (HYPO) radiotherapy.

Methods: Weekly blood test results were extracted from the charts of patients treated within a phase III study comparing HYPO to CF. In order to compare WBC counts at the same nominal dose in both arms and thus to tease out the effect of fractionation, for each recorded WBC value the corresponding cumulative total dose was extracted as well. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1223-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352380PMC
January 2019
1 Read

Analyses of the factors influencing the accuracy of three-dimensional ultrasound in comparison with cone-beam CT in image-guided radiotherapy for prostate cancer with or without pelvic lymph node irradiation.

Radiat Oncol 2019 Jan 29;14(1):22. Epub 2019 Jan 29.

Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, No. 651, Dongfeng Road East, Guangzhou, 510060, China.

Background: Three-dimensional ultrasound (3DUS) is an attractive option in image-guided radiotherapy (IGRT) for prostate cancer (PCa) patients. However, the potential factors influencing the accuracy of 3DUS in comparison with cone-beam CT (CBCT) in IGRT for PCa patients haven't been clearly identified.

Methods: The differences between US/US and CBCT/CT registrations were analyzed over 586 and 580 sessions for 24 and 25 PCa patients treated with or without pelvic lymph node irradiation, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1217-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352439PMC
January 2019
1 Read

Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects.

Radiat Oncol 2019 Jan 29;14(1):21. Epub 2019 Jan 29.

Medical University of Graz, Diagnostic and Research Institute of Pathology, Neue Stiftingtalstrasse 6, 8036, Graz, Austria.

Background: Despite the advances in oncology, patients with bulky tumors have worse prognosis and often receive only palliative treatments. Bulky disease represents an important challenging obstacle for all currently available radical treatment options including conventional radiotherapy. The purpose of this study was to assess a retrospective outcome on the use of a newly developed unconventional stereotactic body radiation therapy (SBRT) for PArtial Tumor irradiation of unresectable bulky tumors targeting exclusively their HYpoxic segment (SBRT-PATHY) that exploits the non-targeted effects of radiotherapy: bystander effects (local) and the abscopal effects (distant). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1227-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352381PMC
January 2019

Role of postoperative radiotherapy in dermatofibrosarcoma protuberans: a propensity score-matched analysis.

Radiat Oncol 2019 Jan 29;14(1):20. Epub 2019 Jan 29.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, 350014, China.

Objective: This study aimed to evaluate the role of postoperative radiotherapy (RT) in dermatofibrosarcoma protuberans (DFSP) and identify the prognostic factors influencing the disease-free survival (DFS).

Methods: A total of 184 patients with DFSP were analyzed from 2000 to 2016. The regression model was used to examine the prognostic factors for DFS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1226-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350344PMC
January 2019
1 Read

Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: comparison between X-ray and proton therapy.

Radiat Oncol 2019 Jan 28;14(1):19. Epub 2019 Jan 28.

Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Idiopathic pulmonary fibrosis (IPF) is associated with fatal complications after radiotherapy (RT) for lung cancer patients; however, the role of proton therapy to reduce the incidence of life-threatening complications is unclear. Herein, we present the preliminary results of early-stage lung cancer patients having IPF and treated with RT, with a focus on the comparison between X-ray and proton therapy.

Methods: From January 2010 to October 2017, we retrospectively reviewed the medical records of 264 patients with stage I-II non-small cell lung cancer (NSCLC) treated with definitive RT alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1221-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348683PMC
January 2019
2 Reads

Overall survival according to immunotherapy and radiation treatment for metastatic non-small-cell lung cancer: a National Cancer Database analysis.

Radiat Oncol 2019 Jan 28;14(1):18. Epub 2019 Jan 28.

Department of Radiation and Cellular Oncology, The University of Chicago Medicine, 5758 S. Maryland Avenue, MC 9006, Chicago, IL, 60637, USA.

Background: Preclinical studies suggest enhanced anti-tumor activity with combined radioimmunotherapy. We hypothesized that radiation (RT) + immunotherapy would associate with improved overall survival (OS) compared to immunotherapy or chemotherapy alone for patients with newly diagnosed metastatic non-small-cell lung cancer (NSCLC).

Methods: The National Cancer Database was queried for patients with stage IV NSCLC receiving chemotherapy or immunotherapy from 2013 to 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1222-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348608PMC
January 2019
1 Read

Simultaneous integrated boost with helical arc radiotherapy of total skin (HEARTS) to treat cutaneous manifestations of advanced, therapy-refractory cutaneous lymphoma and leukemia - dosimetry comparison of different regimens and clinical application.

Radiat Oncol 2019 Jan 28;14(1):17. Epub 2019 Jan 28.

School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: Helical irradiation of the total skin (HITS) was modified as simultaneous integrated boost (SIB)-helical arc radiotherapy of total skin (HEARTS) technique and applied to an acute myeloid leukemia (AML) patient with disseminated leukemia cutis.

Methods: The original HITS plan was revised for different regimens, i.e. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1220-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348688PMC
January 2019
4 Reads

Early stage non-small cell lung cancer treated with pencil beam scanning particle therapy: retrospective analysis of early results on safety and efficacy.

Radiat Oncol 2019 Jan 25;14(1):16. Epub 2019 Jan 25.

Department of Radiation Oncology, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Fudan University, Shanghai, China.

Background: To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC).

Methods: From 08/2014 to 03/2018, 31 consecutive patients with sum of the longest diameters of primary tumor and hilar lymph node < 5 cm, N0-1, M0 NSCLC treated with PT were retrospectively analyzed. Gating/active breathing control techniques were used to control tumor motion in 20 and 7 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1216-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347845PMC
January 2019
2 Reads

Ionizing radiation and bone quality: time-dependent effects.

Radiat Oncol 2019 Jan 22;14(1):15. Epub 2019 Jan 22.

Integrated Dental Clinic Program, Faculty of Dentistry, Federal University of Uberlândia, Avenida Pará s/n°, Campus Umuarama, Bloco 4L, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.

Background: The aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation.

Methods: Wistar rats were submitted to IR (30 Gy) on the left leg and were euthanized after 30 and 60 days. The legs were divided into four groups according to the treatment and euthanization time: C30 and C60 (right leg-without IR), IR30 and IR60 (left leg-with IR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1219-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343359PMC
January 2019
1 Read
2.546 Impact Factor

A scoring system predicting acute radiation dermatitis in patients with head and neck cancer treated with intensity-modulated radiotherapy.

Radiat Oncol 2019 Jan 21;14(1):14. Epub 2019 Jan 21.

Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Kyoto, 606-8507, Japan.

Background And Purpose: We created a scoring system incorporating dosimetric and clinical factors to assess the risk of severe, acute skin reactions in patients undergoing intensity-modulated radiation therapy (IMRT) to treat head and neck cancer (HNC).

Materials And Methods: A total of 101 consecutive patients who received definitive IMRT or volumetric modulated arc therapy (VMAT) with a prescription dose of 70 Gy to treat HNC between 2013 and 2017 in our hospital were enrolled. Skin V, V, V, V V, V, and V values delivered 5 mm within the body contour were compared between patients with Grades 1-2 and Grade 3 dermatitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1215-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341605PMC
January 2019
1 Read

Predicting the survival of patients with bone metastases treated with radiation therapy: a validation study of the Katagiri scoring system.

Radiat Oncol 2019 Jan 18;14(1):13. Epub 2019 Jan 18.

Department of Radiation Oncology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.

Background: The selection of radiation therapy dose fractionation schedules for bone metastases is often based on the estimation of life expectancy. Therefore, accurate prognosis prediction is an important issue. It is reported that the Katagiri scoring system can be used to predict the survival of patients with bone metastases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1218-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339356PMC
January 2019
1 Read

Impact of beam configuration on VMAT plan quality for PinnacleAuto-Planning for head and neck cases.

Radiat Oncol 2019 Jan 18;14(1):12. Epub 2019 Jan 18.

Department of Radiation Oncology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Background: The purpose of this study was to compare automatically generated VMAT plans to find the superior beam configurations for Pinnacle Auto-Planning and share "best practices".

Methods: VMAT plans for 20 patients with head and neck cancer were generated using Pinnacle Auto-Planning Module (Pinnacle Version 9.10) with different beam setup parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1211-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339276PMC
January 2019
1 Read

The influence of a magnetic field on photon beam radiotherapy in a normal human TK6 lymphoblastoid cell line.

Radiat Oncol 2019 Jan 17;14(1):11. Epub 2019 Jan 17.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld (INF) 400, 69120, Heidelberg, Germany.

Background: The implementation of magnetic resonance imaging (MRI) guided radiotherapy (RT) continues to increase. Very limited in-vitro data on the interaction of ionizing radiation and magnetic fields (MF) have been published. In these experiments we focused on the radiation response in a MF of the TK6 human lymphoblastoid cells which are known to be highly radiosensitive due to efficient radiation-induced apoptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1212-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337772PMC
January 2019
1 Read

The prolonged interval between induction chemotherapy and radiotherapy is associated with poor prognosis in patients with nasopharyngeal carcinoma.

Radiat Oncol 2019 Jan 17;14(1). Epub 2019 Jan 17.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

Objectives: Induction chemotherapy (IC) now is gaining recognition for the treatment of nasopharyngeal carcinoma (NPC). The current study was conducted to examine the association between prognosis and the interval between IC and radiotherapy (RT) in NPC patients.

Methods: Patients with newly diagnosed, non-metastatic NPC who were treated with IC followed by RT from 2009 to 2012 were identified from an inpatient database. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1213-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335732PMC
January 2019
4 Reads
2.546 Impact Factor

Grading of MRI-detected skull-base invasion in nasopharyngeal carcinoma with skull-base invasion after intensity-modulated radiotherapy.

Radiat Oncol 2019 Jan 17;14(1):10. Epub 2019 Jan 17.

Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, China.

Background: The aim of this study is to evaluate the prognostic value of grading MRI-detected skull-base invasion in nasopharyngeal carcinoma (NPC) with skull-base invasion after intensity-modulated radiotherapy (IMRT).

Methods: This study is a retrospective chart review of 469 non-metastatic NPC patients with skull-base invasion. Patients were classified as extensive skull-base invasion (ESBI) group and limited skull-base invasion (LSBI) group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1214-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335845PMC
January 2019
1 Read

Tumor location as an indication for adjuvant radiotherapy in pT3N0 rectal cancer after surgery.

Radiat Oncol 2019 Jan 16;14(1). Epub 2019 Jan 16.

Department of Radiation Oncology, SunYat-Sen Memorial Hospital, SunYat-Sen University, Guangzhou, China.

Background: The optimal care for pT3N0 rectal cancer remains controversial. And whether tumor location can be used to guide the administration of adjuvant radiotherapy for pT3N0 rectal cancer is not fully confirmed. The current study was designed to identify the benefit of adjuvant radiotherapy for pT3N0 rectal cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1206-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334427PMC
January 2019
2 Reads

Excluding PTV from lung volume may better predict radiation pneumonitis for intensity modulated radiation therapy in lung cancer patients.

Radiat Oncol 2019 Jan 14;14(1). Epub 2019 Jan 14.

Department of Radiation Medicine, University of Kentucky, Lexington, KY, 40536, USA.

Background: Lung dose-volume histogram (DVH) in radiotherapy could be calculated from multiple normal lung definitions. The lung dosimetric parameters generated from various approaches are significantly different. However, limited evidence shows which definition should be used to more accurately predict radiation pneumonitis (RP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1204-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332547PMC
January 2019
1 Read
2.546 Impact Factor

Direct radiation-induced effects on dental hard tissue.

Radiat Oncol 2019 Jan 11;14(1). Epub 2019 Jan 11.

Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China.

Background: Radiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this study was to evaluate the direct radiation-induced effects on dental hard tissue and investigate their role in the formation of radiation caries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1208-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329176PMC
January 2019
2 Reads

PENELOPE/PRIMO-calculated photon and electron spectra from clinical accelerators.

Radiat Oncol 2019 Jan 11;14(1). Epub 2019 Jan 11.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, and Department of Oncology-Pathology, Karolinska Institutet, Stockholm, SE-171 76, Sweden.

Background: The availability of photon and electron spectra in digital form from current accelerators and Monte Carlo (MC) systems is scarce, and one of the packages widely used refers to linacs with a reduced clinical use nowadays. Such spectra are mainly intended for the MC calculation of detector-related quantities in conventional broad beams, where the use of detailed phase-space files (PSFs) is less critical than for MC-based treatment planning applications, but unlike PSFs, spectra can easily be transferred to other computer systems and users.

Methods: A set of spectra for a range of Varian linacs has been calculated using the PENELOPE/PRIMO MC system. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1186-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330451PMC
January 2019
8 Reads

Palliative radiotherapy to dominant symptomatic lesion in patients with hormone refractory prostate cancer (PRADO).

Radiat Oncol 2019 Jan 10;14(1). Epub 2019 Jan 10.

Department of Oncology and Palliative Units, Zealand University Hospital, Naestved, Denmark.

Background: This study was conducted to investigate a new short-course radiotherapy regimen for patients with metastatic hormone refractory prostate cancer (HRPC) presenting with a dominant debilitating symptom.

Methods / Design: This is an international, multi-center single arm prospective feasibility study that aims to include 34 patients with HRPC and a dominant debilitating symptom. The dominant symptomatic lesion will receive 4 × 5 Gy of high-precision radiotherapy, and the most aggressive part of the lesion 4 × 7 Gy using a simultaneous integrated boost technique. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1209-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327575PMC
January 2019
6 Reads

Long-term results of a phase II study of hypofractionated proton therapy for prostate cancer: moderate versus extreme hypofractionation.

Radiat Oncol 2019 Jan 10;14(1). Epub 2019 Jan 10.

Center for Prostate Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.

Background: We performed a prospective phase II study to compare acute toxicity among five different hypofractionated schedules using proton therapy. This study was an exploratory analysis to investigate the secondary end-point of biochemical failure-free survival (BCFFS) of patients with long-term follow-up.

Methods: Eighty-two patients with T1-3bN0M0 prostate cancer who had not received androgen-deprivation therapy were randomized to one of five arms: Arm 1, 60 cobalt gray equivalent (CGE)/20 fractions/5 weeks; Arm 2, 54 CGE/15 fractions/5 weeks; Arm 3, 47 CGE/10 fractions/5 weeks; Arm 4, 35 CGE/5 fractions/2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-019-1210-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327508PMC
January 2019
2 Reads

Neoadjuvant image-guided helical intensity modulated radiotherapy of extremity sarcomas - a single center experience.

Radiat Oncol 2019 Jan 9;14(1). Epub 2019 Jan 9.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.

Background: Advanced radiotherapy (RT) techniques allow normal tissue to be spared in patients with extremity soft tissue sarcoma (STS). This work aims to evaluate toxicity and outcome after neoadjuvant image-guided radiotherapy (IGRT) as helical intensity modulated radiotherapy (IMRT) with reduced margins based on MRI-based target definition in patients with STS.

Methods: Between 2010 to 2014, 41 patients with extremity STS were treated with IGRT delivered as helical IMRT on a tomotherapy machine. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1207-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327451PMC
January 2019
8 Reads

Simulation of dosimetry impact of 4DCT uncertainty in 4D dose calculation for lung SBRT.

Radiat Oncol 2019 Jan 8;14(1). Epub 2019 Jan 8.

Key Laboratory of Artificial Micro- and Nano- structures of Ministry of Education and Center for Electronic Microscopy, School of Physics and Technology, Wuhan University, Wuhan, 430072, China.

Background: Due to the heterogeneity of patient's individual respiratory motion pattern in lung stereotactic body radiotherapy (SBRT), treatment planning dose assessment using a traditional four-dimensional computed tomography (4DCT_traditional) images based on a uniform breathing curve may not represent the true treatment dose delivered to the patient. The purpose of this study was to evaluate the accumulated dose discrepancy between based on the 4DCT_traditional and true 4DCT (4DCT_true) that incorporated with the patient's real entire breathing motion. The study also explored a novel 4D robust planning strategy to compensate for such heterogeneity respiratory motion uncertainties. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1191-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323842PMC
January 2019
5 Reads

A scoring system to predict local progression-free survival in patients irradiated with 20 Gy in 5 fractions for malignant spinal cord compression.

Radiat Oncol 2018 Dec 29;13(1):257. Epub 2018 Dec 29.

Department of Radiation Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ, USA.

Background: Local progression-free survival (LPFS = stable or improved motor function/resolution of paraplegia during RT without in-field recurrence following RT) is important when treating metastatic spinal cord compression (MSCC). An instrument to estimate LPFS was created to identify patients appropriately treated with short-course RT instead of longer-course RT plus/minus decompressive surgery.

Methods: In 686 patients treated with 20 Gy in 5 fractions alone, ten characteristics were retrospectively analyzed for LPFS including age, interval between tumor diagnosis and RT of MSCC, visceral metastases, other bone metastases, primary tumor type, gender, time developing motor deficits, pre-RT gait function, number of vertebrae affected by MSCC, and performance score. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1203-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311053PMC
December 2018
3 Reads

Outcomes of re-irradiation for brain recurrence after prophylactic or therapeutic whole-brain irradiation for small cell lung Cancer: a retrospective analysis.

Radiat Oncol 2018 Dec 29;13(1):258. Epub 2018 Dec 29.

Department of Radiation Oncology, Unit 97, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030-4009, USA.

Background: Small cell lung cancer (SCLC) can recur in the brain after whole-brain irradiation (WBI). We documented outcomes after treatment of such recurrences and sought predictors of local control and overall survival (OS).

Materials And Methods: Eighty-five patients with SCLC and brain recurrence after prophylactic or therapeutic WBI in 1998-2015 were identified and data were extracted from the medical records. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1205-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310962PMC
December 2018

DPM as a radiation transport engine for PRIMO.

Radiat Oncol 2018 Dec 27;13(1):256. Epub 2018 Dec 27.

West German Proton Therapy Centre Essen (WPE), Hufelandstraße 55, Essen, D-45147, Germany.

Background: PRIMO is a dose verification system based on the general-purpose Monte Carlo radiation transport code PENELOPE, which implements an accurate physics model of the interaction cross sections and the radiation transport process but with low computational efficiency as compared with fast Monte Carlo codes. One of these fast Monte Carlo codes is the Dose Planning Method (DPM). The purpose of this work is to describe the adaptation of DPM as an alternative PRIMO computation engine, to validate its performance against PENELOPE and to validate it for some specific cases. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307123PMC
December 2018
5 Reads

Recommendation for the definition of postoperative radiotherapy target volume based on a pooled analysis of patterns of failure after radical surgery among patients with thoracic esophageal squamous cell carcinoma.

Radiat Oncol 2018 Dec 27;13(1):255. Epub 2018 Dec 27.

Department of Radiation Oncology, Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, 270 Dongan Road, Xuhui, Shanghai, 200032, China.

Background: Elective use of radiation therapy to treat regionally involved lymph nodes (LNs) after radical surgery for esophageal squamous cell carcinoma (ESCC) is controversial. We studied metastasis patterns through a pooled analysis of published results to guide post-operative radiotherapy (PORT) target designation.

Methods: We searched the MEDLINE database for literature published from May 1977 to March 2018, and found 14 relevant original studies that included 2738 patients with thoracic ESCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1199-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307221PMC
December 2018
3 Reads

Image-guided study of inter-fraction and intra-fraction set-up variability and margins in reverse semi-decubitus breast radiotherapy.

Radiat Oncol 2018 Dec 27;13(1):254. Epub 2018 Dec 27.

Department of Radiation Oncology, MacKay Memorial Hospital, 92, Section 2, Chung-Shan North Road, Taipei, 104, Taiwan.

Background: This study aimed to evaluate the inter-fraction set-up error and intra-fraction motion during reverse semi-decubitus (RSD) breast radiotherapy, and to determine a planning target volume (PTV) margin.

Material And Methods: Pre- and post-treatment cone-beam computed tomography (CBCT) scans were prospectively acquired at fractions 1, 4, 7, 8, 11, and 14 for 30 patients who underwent RSD breast radiotherapy. Online correction for initial set-up error greater than 5 mm or 2° was performed and post-correction CBCT was acquired. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1200-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307193PMC
December 2018
2 Reads

Progression of hearing loss after LINAC-based stereotactic radiotherapy for vestibular schwannoma is associated with cochlear dose, not with pre-treatment hearing level.

Radiat Oncol 2018 Dec 24;13(1):253. Epub 2018 Dec 24.

Department of Radiotherapy, Erasmus MC Cancer Institute, Postbus 2040, Rotterdam, 3000, CA, The Netherlands.

Background: Although stereotactic radiotherapy (SRT) for vestibular schwannoma has demonstrated excellent local control rates, hearing deterioration is often reported after treatment. We therefore wished to assess the change in hearing loss after SRT and to determine which patient, tumor and treatment-related factors influence deterioration.

Methods: We retrospectively analyzed progression of hearing loss in patients with vestibular schwannoma who had received stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) as a primary treatment between 2000 and 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1202-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304756PMC
December 2018
1 Read

Efficacy of pre-operative stereotactic radiosurgery followed by surgical resection and correlative radiobiological analysis for patients with 1-4 brain metastases: study protocol for a phase II trial.

Radiat Oncol 2018 Dec 20;13(1):252. Epub 2018 Dec 20.

Department of Neurosurgery, Indiana University School of Medicine, Indiana University Purdue University Indianapolis, Neuroscience Research Building, 320 W 15th Street, NB 400A, Indiana, IN, 46202, USA.

Background: Stereotactic radiosurgery (SRS) has emerged as a common adjuvant modality used with surgery for resectable brain metastases (BMs). However, the optimal sequence of the multi-modality therapy has not been established. The goal of the study is to evaluate 6-month local control utilizing pre-operative SRS followed by surgical resection for patients with 1-4 brain metastases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1178-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302493PMC
December 2018
1 Read

Locally dose-escalated radiotherapy may improve intracranial local control and overall survival among patients with glioblastoma.

Radiat Oncol 2018 Dec 19;13(1):251. Epub 2018 Dec 19.

Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: The dismal overall survival (OS) prognosis of glioblastoma, even after trimodal therapy, can be attributed mainly to the frequent incidence of intracranial relapse (ICR), which tends to present as an in-field recurrence after a radiation dose of 60 Gray (Gy). In this study, molecular marker-based prognostic indices were used to compare the outcomes of radiation with a standard dose versus a moderate dose escalation.

Methods: This retrospective analysis included 156 patients treated between 2009 and 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1194-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299982PMC
December 2018

Additional radiation boost to whole brain radiation therapy may improve the survival of patients with brain metastases in small cell lung cancer.

Radiat Oncol 2018 Dec 18;13(1):250. Epub 2018 Dec 18.

Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.

Background: The role of the dose escalation strategy in brain radiotherapy for small cell lung cancer (SCLC) patients with brain metastases (BMs) has not been identified. This study aims to determine whether an additional radiation boost to whole brain radiation therapy (WBRT) has beneficial effects on overall survival (OS) compared with WBRT-alone.

Methods: A total of 82 SCLC patients who were found to have BMs treated with WBRT plus a radiation boost (n = 33) or WBRT-alone (n = 49) from January 2008 to December 2015 were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1198-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299519PMC
December 2018
2 Reads

Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy.

Radiat Oncol 2018 Dec 17;13(1):249. Epub 2018 Dec 17.

Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Concurrent chemoradiotherapy (CCRT) is effective in the treatment of locally advanced cervical squamous cell carcinoma (SCC). However, whether treatment outcomes of cervical adenocarcinoma are equivalent to SCC after CCRT has been a topic of debate.

Methods: Medical records of cervical cancer patients treated with definitive radiotherapy or CCRT in our institute from January 2011 to December 2014 were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1197-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296025PMC
December 2018
6 Reads

Feasibility of a novel dose fractionation strategy in TMI/TMLI.

Radiat Oncol 2018 Dec 17;13(1):248. Epub 2018 Dec 17.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Background: To report our experience in planning and delivering total marrow irradiation (TMI) and total marrow and lymphatic irradiation (TMLI) in patients with hematologic malignancies.

Methods: Twenty-seven patients undergoing bone marrow transplantation were treated with TMI/TMLI using Helical Tomotherapy (HT). All skeletal bones exclusion of the mandible comprised the treatment target volume and, for TMLI, lymph node chains, liver, spleen and/or brain were also included according to the clinical indication. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1201-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296054PMC
December 2018
3 Reads

Adoption of prophylactic cranial irradiation (PCI) for extensive stage small cell lung cancer (ES-SCLC): a population based outcome study.

Radiat Oncol 2018 Dec 14;13(1):247. Epub 2018 Dec 14.

Division of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.

Background: The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and after publication of the European RCT and its association with survival in ES-SCLC.

Methods: We identified eligible patients in the only two Singapore national cancer centres from 2003 to 2010. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1184-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295074PMC
December 2018
5 Reads

Endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer: choice of new approach.

Radiat Oncol 2018 Dec 14;13(1):246. Epub 2018 Dec 14.

Department of Radiology, Kyoto Prefectural University Graduate School of Medical Science, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with extended lymph node dissection is highly invasive. Recent reports have shown that endoscopic submucosal dissection (ESD) followed by chemoradiotherapy (CRT) has promising results and might become a new therapeutic approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1195-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295044PMC
December 2018
2 Reads

Clinical outcomes of radiation therapy for clinical T4b oesophageal cancer with airway invasion.

Radiat Oncol 2018 Dec 14;13(1):245. Epub 2018 Dec 14.

Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Oesophageal cancer with airway invasion presents a challenge for therapy and often has serious complications. We analysed the clinical outcomes of radiation therapy (RT) in patients with clinical T4b oesophageal cancer with airway invasion.

Methods: We retrospectively reviewed the medical records of 73 patients with oesophageal cancer who had clinical T4 disease and who received RT between January 1994 and June 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1196-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295084PMC
December 2018
2 Reads

Assessment of the modulation degrees of intensity-modulated radiation therapy plans.

Radiat Oncol 2018 Dec 13;13(1):244. Epub 2018 Dec 13.

Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.

Background: To evaluate the modulation indices (MIs) for predicting the plan delivery accuracies of intensity-modulated radiation therapy (IMRT) plans.

Methods: A total of 100 dynamic IMRT plans that used TrueBeam STx and 102 dynamic IMRT plans that used Trilogy were selected. For each plan, various MIs were calculated, which included the modulation complexity score (MCS), plan-averaged beam area (PA), plan-averaged beam irregularity (PI), plan-averaged beam modulation (PM), MI quantifying multi-leaf collimator (MLC) speeds (MI), MI quantifying MLC acceleration (MI), and MI quantifying MLC acceleration and segment aperture irregularity (MI). Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1193-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293636PMC
December 2018
5 Reads

Surface scanning for 3D dose calculation in intraoperative electron radiation therapy.

Radiat Oncol 2018 Dec 7;13(1):243. Epub 2018 Dec 7.

Instituto de Investigación Sanitaria Gregorio Marañón. Calle Doctor Esquerdo, 46, 28007, Madrid, Spain.

Background: Dose calculations in intraoperative electron radiation therapy (IOERT) rely on the conventional assumption of water-equivalent tissues at the applicator end, which defines a flat irradiation surface. However, the shape of the irradiation surface modifies the dose distribution. Our study explores, for the first time, the use of surface scanning methods for three-dimensional dose calculation of IOERT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1181-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286593PMC
December 2018
1 Read
2.546 Impact Factor

Performance of gimbal-based dynamic tumor tracking for treating liver carcinoma.

Radiat Oncol 2018 Dec 5;13(1):242. Epub 2018 Dec 5.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany.

Background: Since the introduction of tumor tracking in radiotherapy, it is possible to ensure a precise irradiation of moving targets. To follow the tumor movement, most systems rely on the detection of implanted markers and correlation models between the internal and external patient movement. This study reports the clinical workflow and first results of the dynamic tumor tracking (DTT) performance for patients with liver carcinoma at the Vero SBRT system of the University Hospital Erlangen regarding the detection of the internal marker and the changes of the determined correlation models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-018-1180-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280466PMC
December 2018
2 Reads