14,361 results match your criteria Radiation Necrosis


Clinical Experience of Bevacizumab for Radiation Necrosis in Patients with Brain Metastasis.

Brain Tumor Res Treat 2020 Jul 9. Epub 2020 Jul 9.

Neuro-Oncology Clinic, National Cancer Center Korea, Goyang, Korea.

Background: As the application of radiotherapy to brain metastasis (BM) increases, the incidence of radiation necrosis (RN) as a late toxicity of radiotherapy also increases. However, no specific treatment for RN is indicated except long-term steroids. Here, we summarize the clinical results of bevacizumab (BEV) for RN. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e11DOI Listing

Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins.

Ann Transl Med 2020 Jun;8(12):757

Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: Cerebral ischemia (CI) can lead to ischemic stroke. The most effective therapy for cerebral ischemic stroke is the early restoration of blood reperfusion. However, reperfusion after CI can result in cerebral ischemia reperfusion (CI/R) injury. Read More

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http://dx.doi.org/10.21037/atm-20-4258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333167PMC

Current status of PET imaging in neuro-oncology.

Neurooncol Adv 2019 May-Dec;1(1):vdz010. Epub 2019 May 28.

Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany.

Over the past decades, a variety of PET tracers have been used for the evaluation of patients with brain tumors. For clinical routine, the most important clinical indications for PET imaging in patients with brain tumors are the identification of neoplastic tissue including the delineation of tumor extent for the further diagnostic and therapeutic management (ie, biopsy, resection, or radiotherapy planning), the assessment of response to a certain anticancer therapy including its (predictive) effect on the patients' outcome and the differentiation of treatment-related changes (eg, pseudoprogression and radiation necrosis) from tumor progression at follow-up. To serve medical professionals of all disciplines involved in the diagnosis and care of patients with brain tumors, this review summarizes the value of PET imaging for the latter-mentioned 3 clinically relevant indications in patients with glioma, meningioma, and brain metastases. Read More

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http://dx.doi.org/10.1093/noajnl/vdz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324052PMC

[Tc]-Bis-Methionine-DTPA Single-Photon Emission Computed Tomography Impacting Glioma Management: A Sensitive Indicator for Postsurgical/Chemoradiotherapy Response Assessment.

Cancer Biother Radiopharm 2020 Jul 9. Epub 2020 Jul 9.

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Science, DRDO, New Delhi, India.

The present study evaluated the prognostic value of [Tc]MDM (bis-methionine-DTPA) follow-up single-photon emission computed tomography (SPECT) imaging for response assessment to chemoradiotherapy in glioma postoperatively. One hundred fourteen glioma patients (80 M:34 F) were followed postoperatively by sequential [Tc]MDM SPECT, dynamic susceptibility contrast-enhanced (DSCE)-MRI, and magnetic resonance spectroscopy (MRS) at baseline, 6, 12, and 22.5 months postchemoradiotherapy. Read More

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http://dx.doi.org/10.1089/cbr.2020.3696DOI Listing

A simple score to estimate the likelihood of pseudoprogression vs. recurrence following stereotactic radiosurgery for brain metastases: The Bergen Criteria.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa026. Epub 2020 Mar 10.

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Background: A major challenge in the follow-up of patients treated with stereotactic radiosurgery (SRS) for brain metastases (BM) is to distinguish pseudoprogression (PP) from tumor recurrence (TR). The aim of the study was to develop a clinical risk assessment score.

Methods: Follow-up images of 87 of 97 consecutive patients treated with SRS for 348 BM were analyzed. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212847PMC

A Nomogram to Predict Symptomatic Epilepsy in Patients with Radiation-induced Brain Necrosis.

Neurology 2020 Jul 6. Epub 2020 Jul 6.

Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

Objective: This study aimed to develop and validate a nomogram to predict epilepsy in patients with radiation-induced brain necrosis (RN).

Methods: The nomogram was based on a retrospective analysis of 302 patients who were diagnosed with symptomatic RN from January 2005 to January 2016 in Sun Yat-sen Memorial Hospital using the Cox proportional hazards model. Discrimination of the nomogram was assessed by the concordance index (-index) and the calibration curve. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010190DOI Listing

Cancer and Rheumatoid Arthritis.

Rheum Dis Clin North Am 2020 Aug 7;46(3):445-462. Epub 2020 Jun 7.

Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Unit 1444, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Management of rheumatoid arthritis (RA) in patients with cancer is complex and requires a multidisciplinary approach. A few studies have examined the risk for recurrence in patients with RA receiving disease-modifying antirheumatic drugs, primarily tumor necrosis factor-α inhibitors. Although these agents seem to be safe in patients with a history of cancer and no evidence of disease, additional information is needed to determine their potential effects in patients with RA and active cancer. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.05.003DOI Listing

Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway.

Nutrients 2020 Jun 30;12(7). Epub 2020 Jun 30.

Life Science Institute, BioSpectrum, Yongin 16827, Gyeonggi, Korea.

Continuous exposure to ultraviolet B (UVB) can cause photodamage of the skin. This photodamage can be inhibited by the overexpression of the non-coding RNA, nc886, via the protein kinase RNA-activated (PKR) pathway. The study aims to identify how UVB inhibits nc886 expression, and it also seeks to determine whether substances that can control nc886 expression can influence UV-induced inflammation, and the mechanisms involved. Read More

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http://dx.doi.org/10.3390/nu12071958DOI Listing

Salvage Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Primary Surgical Resection of Non-small-cell Lung Cancer.

Clin Lung Cancer 2020 Jun 2. Epub 2020 Jun 2.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

Introduction: We sought to evaluate the safety and efficacy of stereotactic body radiation therapy (SBRT) as salvage treatment for local recurrence after prior surgical resection for non-small-cell lung cancer (NSCLC).

Materials And Methods: We surveyed our prospective lung SBRT registry for patients who received salvage SBRT (sSBRT) for local recurrence after previous resection of a primary NSCLC. Following sSBRT, local control, distant metastases, overall survival, and treatment-related toxicity were evaluated. Read More

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http://dx.doi.org/10.1016/j.cllc.2020.05.025DOI Listing

Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing.

F1000Res 2019 2;8:613. Epub 2019 May 2.

Department of Medical Genetics and Science and Technology Unit, Umm-Al-Qura University, Makkah, Makkah, Saudi Arabia.

Ependymomas are glial tumors derived from differentiated ependymal cells. In contrast to other types of brain tumors, histological grading is not a good prognostic marker for these tumors. In order to determine genomic changes in an anaplastic ependymoma, we analyzed its mutation patterns by next generation sequencing (NGS). Read More

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http://dx.doi.org/10.12688/f1000research.18721.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317822PMC

Can neoadjuvant chemotherapy improve survival in stage T3-4N1 nasopharyngeal carcinoma? A propensity matched analysis.

Radiat Oncol 2020 Jul 2;15(1):160. Epub 2020 Jul 2.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, No. 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

Background: To estimate the efficacy of neoadjuvant chemotherapy (NCT) in stage T3-4N1 nasopharyngeal carcinoma (NPC).

Methods: Data on stage T3-4N1 NPC patients treated with concurrent chemoradiotherapy (CCRT) with or without NCT at the Sun Yat-sen University Cancer Center between January 2006 and December 2013 were retrospectively reviewed. Propensity score matching (PSM) was carried out to balance prognostic factors in NCT followed by CCRT (NCT + CCRT) group and CCRT group in a 1:1 ratio. Read More

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http://dx.doi.org/10.1186/s13014-020-01594-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331182PMC

Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics.

Cell Rep 2020 Jun;31(13):107830

Princess Margaret Cancer Center, University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON M5G 1L7, Canada; Department of Radiation Oncology, University of Toronto, 149 College Street, Toronto, ON M5T 1P5, Canada. Electronic address:

The kinetics of circulating cell-free DNA (cfDNA) release may provide a real-time assessment of induced cell death. However, there is a limited understanding of the underlying biological rationale for cfDNA release following distinct treatments and cell death mechanisms. Here, we uncover a complex interplay between apoptosis, necrosis, and senescence in determining cfDNA release kinetics. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107830DOI Listing

Optimal breast reconstruction type for patients treated with neoadjuvant chemotherapy, mastectomy followed by radiation therapy.

Breast Cancer Res Treat 2020 Jun 30. Epub 2020 Jun 30.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

Purpose: To explore the optimal type of breast reconstruction and the time interval to postmastectomy radiotherapy (PMRT) associated with lower complications in breast cancer patients receiving neoadjuvant chemotherapy.

Methods: We reviewed the medical records of 300 patients who received neoadjuvant chemotherapy, mastectomy with breast reconstruction and PMRT at our institution from 2000 to 2017. Reconstruction types included autologous flaps (AR), single-stage-direct-to-implant and two-stages expander/implant (TE/I). Read More

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http://dx.doi.org/10.1007/s10549-020-05747-7DOI Listing

Prognostic value and the potential role of treatment options for cervical lymph node necrosis in nasopharyngeal carcinoma.

Oral Oncol 2020 Jun 27;109:104864. Epub 2020 Jun 27.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, People's Republic of China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Centre, Guangzhou, Guangdong 510060, People's Republic of China. Electronic address:

Objective: There were few studies focused on the cervical lymph necrosis (CNN) of nasopharyngeal carcinoma (NPC) patients to develop a nomogram and guide the treatment decision at the era of intensity modulated radiation therapy (IMRT).

Material And Methods: The prognostic accuracy of CNN in the training cohort (n = 1940) was validated in Guangzhou internal validation cohort (n = 832) and two external validation cohorts (Dongguan, n = 232; Foshan, n = 134).

Results: The primary end point was progression-free survival (PFS), calculated using the Kaplan-Meier method. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104864DOI Listing

Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1.

Mol Oncol 2020 Jun 30. Epub 2020 Jun 30.

Genetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich GmbH, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.

Nonsense-mediated decay (NMD) proteins are responsible for the surveillance and degradation of aberrant RNAs. Suppressor with morphogenetic effect on genitalia 7 (SMG7) is an NMD complex protein and a regulator of tumor necrosis factor (TNF)-induced extrinsic apoptosis, however, this unique function has not been explored in detail. In this study, we show that loss of Smg7 leads to unrestricted expression of long non-coding RNAs (lncRNAs) in addition to NMD targets. Read More

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http://dx.doi.org/10.1002/1878-0261.12754DOI Listing

Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases.

J Neurooncol 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT, 06520, USA.

Purpose: Both laser interstitial thermal therapy (LITT) and bevacizumab have been used successfully to treat radiation necrosis (RN) after radiation for brain metastases. Our purpose is to compare pre-treatment patient characteristics and outcomes between the two treatment options.

Methods: Single-institution retrospective chart review identified brain metastasis patients who developed RN between 2011 and 2018. Read More

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http://dx.doi.org/10.1007/s11060-020-03570-0DOI Listing
June 2020
3.070 Impact Factor

Neurological and Medical Complications in Brain Tumor Patients.

Curr Neurol Neurosci Rep 2020 Jun 29;20(8):33. Epub 2020 Jun 29.

Department of Neurology, University of Virginia, P.O. Box 800432, Charlottesville, VA, 22908, USA.

Purpose Of Review: Patients with brain tumors are susceptible to multiple complications that can affect their survival or quality of life. The scope of these complications is widening due to prolonged overall survival and improved therapies. In this review, we discuss the most common complications in this patient population focusing on the recent literature. Read More

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http://dx.doi.org/10.1007/s11910-020-01054-2DOI Listing

Neurologic Complications of Cranial Radiation Therapy and Strategies to Prevent or Reduce Radiation Toxicity.

Curr Neurol Neurosci Rep 2020 Jun 29;20(8):34. Epub 2020 Jun 29.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Purpose Of Review: Radiation therapy is an important treatment for patients with brain tumors but can have significant neurologic complications. This review highlights the broad spectrum of short-term and long-term neurologic complications that can occur in patients receiving cranial radiation therapy, and strategies to prevent and treat such complications.

Recent Findings: Despite significant improvements in radiotherapy delivery, there are neurologic complications that can result from treatment. Read More

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http://dx.doi.org/10.1007/s11910-020-01051-5DOI Listing

Pericardectomy after pericarditis constrictiva led to onset of transplant kidney function after 98 days of anuric kidney graft: a case report.

BMC Nephrol 2020 Jun 29;21(1):241. Epub 2020 Jun 29.

Department of Nephrology and Hypertension, University Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Germany.

Background: Constrictive pericarditis is easily overlooked and can lead to severe problems in hemodynamics and end-organ perfusion, in our patient leading to 98 days of anuria after living kidney transplantation. This was completely reversible after pericardectomy.

Case Presentation: A 43-year-old female caucasian patient received a living kidney donation from her mother. Read More

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http://dx.doi.org/10.1186/s12882-020-01899-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324971PMC

-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERK/p38 and NF-B Pathways in LPS-Exposed BV2 Cells.

Biomed Res Int 2020 27;2020:7532306. Epub 2020 May 27.

Department of Radiation Oncology and Therapy, The First Hospital of Jilin University, Changchun 130021, China.

Neurodegenerative disease is a disease state in which neurons in the spinal cord and brain are lost. Studies show that sustained neuroinflammatory reactions release toxic factors, damage neurons, and lead to neurodegenerative diseases. Therefore, inhibiting neuroinflammation may be an effective measure to alleviate neurodegenerative diseases. Read More

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http://dx.doi.org/10.1155/2020/7532306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273476PMC

Brachytherapy for meningiomas.

Handb Clin Neurol 2020 ;170:303-307

Miami Neuroscience Institute, Baptist Health of South Florida, Miami, FL, United States; Division of Neuroscience, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States. Electronic address:

Interstitial intracranial radiotherapy implants, or brachytherapy, is an adjuvant option for treatment of recurrent high-grade meningiomas after resection. The implants are placed in the resection cavity following tumor resection. The most commonly used isotope is Iodine-125 (I-125). Read More

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http://dx.doi.org/10.1016/B978-0-12-822198-3.00049-5DOI Listing
January 2020

Temporal Lobe Necrosis in Head and Neck Cancer Patients after Proton Therapy to the Skull Base.

Int J Part Ther 2020 28;6(4):17-28. Epub 2020 May 28.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: To demonstrate temporal lobe necrosis (TLN) rate and clinical/dose-volume factors associated with TLN in radiation-naïve patients with head and neck cancer treated with proton therapy where the field of radiation involved the skull base.

Materials And Methods: Medical records and dosimetric data for radiation-naïve patients with head and neck cancer receiving proton therapy to the skull base were retrospectively reviewed. Patients with <3 months of follow-up, receiving <45 GyRBE or nonconventional fractionation, and/or no follow-up magnetic resonance imaging (MRI) were excluded. Read More

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http://dx.doi.org/10.14338/IJPT-20-00014.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302730PMC

Arthroscopically-assisted reduction and pinning of a radial neck fracture in a child: a case report and review of the literature.

J Med Case Rep 2020 Jun 25;14(1):78. Epub 2020 Jun 25.

Department of Orthopaedic and Traumatology Surgery, Azienda Ospedaliero-Universitaria S. Anna Cona, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.

Background: Displaced radial neck fractures in children are challenging to treat. The age of the patient and the degree of angulation are the main criteria to consider when managing these fractures in children. Various surgical techniques have been described in the literature for both indirect and direct reduction and for fixation. Read More

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http://dx.doi.org/10.1186/s13256-020-02390-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315511PMC

Reconstructing Ear Defects Using the Revolving Door Island Flap: A Case Series.

Actas Dermosifiliogr 2020 Jun 21. Epub 2020 Jun 21.

Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Background And Objectives: Defects of the anterior region of the pinna pose a reconstruction challenge owing to the complex topography and difficult access. We report our experience using the revolving door island flap (RDIF) to reconstruct pinna defects and present the surgical results.

Material And Methods: Retrospective descriptive study of patients undergoing ear reconstruction using RDIF at different sites of the anterior region after resection of malignant tumors. Read More

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http://dx.doi.org/10.1016/j.ad.2020.03.002DOI Listing

[Basaloid squamous cell carcinoma in gingiva: a case report].

Hua Xi Kou Qiang Yi Xue Za Zhi 2020 Jun;38(3):343-346

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

As an aggressive subtype of squamous cell carcinoma, basaloid squamous cell carcinoma (BSCC) rarely occurs in the oral and maxillofacial region. The gingiva is an unusual site of BSCC. This study reported a 78-year-old male who presented with left maxillary pain. Read More

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http://dx.doi.org/10.7518/hxkq.2020.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296367PMC

[A Case of Radiation Necrosis in the Right Occipital Lobe Accompanied with Massive Hemorrhage:Histopathological Analysis].

No Shinkei Geka 2020 Jun;48(6):541-546

Department of Neurosurgery, Japanese Red Cross Fukuoka Hospital.

Radiation necrosis with massive hemorrhage is a rare complication of radiotherapy. We report the case of a male patient who had undergone radiotherapy therapy 18 years earlier and presently underwent gamma knife radiosurgery for a metastatic brain tumor in his right occipital lobe. The patient showed aberrant behavior with left homonymous hemianopsia and a gradual deterioration of cognitive function after radiotherapy. Read More

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http://dx.doi.org/10.11477/mf.1436204225DOI Listing

Gamma Radiation-Attenuated Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820926593

Radiation Biology Department, National Center for Radiation Research and Technology, Atomic Energy authority, Cairo, Egypt.

Purpose: Pathological angiogenesis and apoptosis evasions are common hallmarks of cancer. A different approach to the antitumor effect of parasitic diseases caused by certain protozoans and helminthes had been adopted in recent years as they can affect many cancer characteristics. The present work is an attempt to assess the effect of gamma radiation-attenuated ME49 as an antiapoptotic and angiogenic regulator modifier on tumor growth aimed at improving cancer protective protocols. Read More

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http://dx.doi.org/10.1177/1533033820926593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309383PMC

Peripheral Artery Disease and Stroke.

J Cardiovasc Echogr 2020 Apr 10;30(Suppl 1):S17-S25. Epub 2020 Apr 10.

Cardiology Department, Hospital 'Bianchi Melacrino Morelli' Reggio Calabria, Italy.

Peripheral artery disease (PAD) and stroke can occur as vascular complication of anticancer treatment. Although the mechanisms, monitoring, and management of cardiotoxicities have received broad attention, vascular toxicities remain often underrecognized. In addition, the development of new chemotherapeutic drugs bears the risk of vasotoxicities that are yet to be identified and may not be realized with short-term follow-up periods. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_4_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293872PMC

Differentiation of intra-abdominal desmoid tumor from peritoneal seeding based on CT and/or F-FDG PET-CT in patients with history of cancer surgery.

Abdom Radiol (NY) 2020 Jun 19. Epub 2020 Jun 19.

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Purpose: To investigate differential imaging features of intra-abdominal desmoid tumors and peritoneal seeding in patients with history of cancer surgery.

Methods: Thirty-two patients who had a single pathologically proven intra-peritoneal lesion that developed after cancer surgery were enrolled between January 2000 and June 2019. There were 16 desmoid tumors and 16 peritoneal seeding lesions. Read More

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http://dx.doi.org/10.1007/s00261-020-02620-5DOI Listing

Mesoporous Bi-Containing Radiosensitizer Loading with DOX to Repolarize Tumor-Associated Macrophages and Elicit Immunogenic Tumor Cell Death to Inhibit Tumor Progression.

ACS Appl Mater Interfaces 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China.

Tumor-associated macrophages (TAMs) were a major component of tumor, which comprised up to 50% of tumor mass, and correlated with poor prognosis in more than 80% of cases. TAMs were resistant to radiotherapy and chemotherapy, and radiation could further activate TAMs to promote tumor progression. Herein, we explored a kind of Bi-based mesoporous upconversion nanophosphor (UCNP) loaded with doxorubicin (UCNP-DOX) to elicit immunogenic tumor cell death and repolarize TAMs to an antitumor M1-like type for strengthening the tumor-specific antitumor immune effects of X-ray radiotherapy. Read More

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http://dx.doi.org/10.1021/acsami.0c08074DOI Listing

Successful two-stage operation for esophageal necrosis due to proton beam therapy followed by sorafenib in a case of large hepatocellular carcinoma.

Surg Case Rep 2020 Jun 16;6(1):138. Epub 2020 Jun 16.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan.

Background: Locally advanced hepatocellular carcinoma (HCC), which is unsuitable for standard locoregional therapies, remains a challenge to manage. Among the recently developed treatments, proton beam therapy (PBT) has been reported to achieve good local control. However, in patients with large HCC adjacent to the esophagus, high-dose PBT may rarely lead to radiation-induced esophageal necrosis or perforation. Read More

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http://dx.doi.org/10.1186/s40792-020-00902-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297925PMC

Linac-based fractionated stereotactic radiotherapy with a micro-multileaf collimator for large brain metastasis unsuitable for surgical resection.

J Radiat Res 2020 Jul;61(4):546-553

Department of Radiation Oncology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

The aim of this study was to assess clinical outcomes using linac-based, fractionated, stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for large brain metastasis (LBM) unsuitable for surgical resection. Between January 2009 and October 2018 we treated 21 patients with LBM using linac-based fSRT. LBM was defined as a tumor with ≥30 mm maximal diameter in gadolinium-enhanced magnetic resonance images. Read More

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http://dx.doi.org/10.1093/jrr/rraa038DOI Listing

Radiotherapy Induces Intestinal Barrier Dysfunction by Inhibiting Autophagy.

ACS Omega 2020 Jun 27;5(22):12955-12963. Epub 2020 May 27.

Department of Pharmacy, the Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330003, People's Republic of China.

Radiation enteritis is a common complication of abdominal irradiation (IR) therapy. However, the molecular mechanism of radiation enteritis accompanied by impaired intestinal barrier function is not clear. The aim of this study was to investigate the important role of autophagy in radiation-induced intestinal barrier function impairment. Read More

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http://dx.doi.org/10.1021/acsomega.0c00706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288592PMC

A Nomogram for Predicting Distant Metastasis Using Nodal-Related Features Among Patients With Nasopharyngeal Carcinoma.

Front Oncol 2020 29;10:616. Epub 2020 May 29.

Cancer Prevention Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Distant metastasis is among the main reasons for treatment failure in nasopharyngeal carcinoma (NPC) patients. To identify patients with a high risk of distant metastasis is important to guide posttreatment surveillance, appropriate time treatments, and prolonging their long-term survival. In this study, we systematically examined the associations between a series of nodal-related characteristics and distant metastasis-free survival (DMFS) by detailed MRI reading and established a nomogram for DMFS in NPC patients. Read More

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http://dx.doi.org/10.3389/fonc.2020.00616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273517PMC

A Nomogram for the Prognosis of Nasopharyngeal Carcinoma with MR Imaging-Detected Tumor Residue at the End of Intensity-Modulated Radiotherapy.

Cancer Manag Res 2020 25;12:3835-3844. Epub 2020 May 25.

Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Radiation Oncology Clinical Medical Research Center of Guangxi, Nanning 530021, Guangxi, People's Republic of China.

Objective: This study set out to institute an effective nomogram to predict the prognosis of nasopharyngeal carcinoma (NPC) using magnetic resonance imaging (MRI)-detected residual tumor at the end of intensity-modulated radiotherapy (IMRT).

Background: This study retrospectively analyzed the prognostic factors of NPC using MRI-detected residual tumor at the end of IMRT, in order to individualize the treatment of patients with poor prognosis as early as possible.

Methods: Overall, 162 NPC patients with local or regional residual tumor at the end of IMRT were retrospectively analyzed. Read More

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http://dx.doi.org/10.2147/CMAR.S252047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261616PMC

TP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival.

Cancers (Basel) 2020 Jun 11;12(6). Epub 2020 Jun 11.

Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia.

Lung cancer poses the greatest cancer-related death risk and males have poorer outcomes than females, for unknown reasons. Patient sex is not a biological variable considered in lung cancer standard of care. Correlating patient genetics with outcomes is predicted to open avenues for improved management. Read More

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http://dx.doi.org/10.3390/cancers12061535DOI Listing

LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.

Autophagy 2020 Jun 26:1-16. Epub 2020 Jun 26.

School of Life Science and Technology, ShanghaiTech University , Shanghai, China.

Macroautophagy/autophagy is a membrane-mediated intracellular degradation pathway, through which bulky cytoplasmic content is digested in lysosomes. How the autophagy initiation and maturation steps are regulated is not clear. In this study, we found an E3 ubiquitin ligase complex, linear ubiquitin chain assembly complex (LUBAC) and a deubiquitinating enzyme (DUB) OTULIN localize to the phagophore area to control autophagy initiation and maturation. Read More

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http://dx.doi.org/10.1080/15548627.2020.1781393DOI Listing

Diving Into Radiation Necrosis: Hyperbaric Oxygen Therapy in Cerebral Radiation Necrosis.

JCO Oncol Pract 2020 Jun 15:OP2000058. Epub 2020 Jun 15.

Brooke Army Medical Center, San Antonio, TX.

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http://dx.doi.org/10.1200/OP.20.00058DOI Listing

Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats.

Mol Biol Rep 2020 Jun 14. Epub 2020 Jun 14.

Radiation Biology Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.

Cyclophosphamide (CP) is a nitrogen mustard alkylating agent with effective antineoplastic, immunomodulatory and immunosuppressive properties. Despite its vast therapeutic uses, it is known to trigger strict cardiac toxicity. The objective of the current study was to examine the protective role of metformin (MET) and/or low dose radiation (LDR) on cardiotoxicity and apoptosis induced by CP in rats. Read More

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http://dx.doi.org/10.1007/s11033-020-05582-5DOI Listing

Radiation-induced Osteomyelitis/Osteonecrosis of the Rib: SPECT/CT Imaging for Successful Surgical Management.

Plast Reconstr Surg Glob Open 2019 Dec 30;7(12):e2536. Epub 2019 Dec 30.

Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.

Chronic radiation-induced osteomyelitis/necrosis of the rib was rarely encountered in breast cancer patients even before the era of breast-conserving therapy. Few studies have focused on how to evaluate the extent of rib osteomyelitis for surgical management. A 78-year-old woman who had received radiation therapy after a radical mastectomy due to breast cancer 30 years ago manifested a rib pain and chest skin ulcers. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288890PMC
December 2019

Feasibility study evaluating arrhythmogenesis and cardiac damage after heart-base irradiation in mice: A brief communication.

Vet Med Sci 2020 Jun 10. Epub 2020 Jun 10.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

Radiation-induced heart disease (RIHD) is a potential cause of morbidity and mortality in dogs undergoing thoracic irradiation. Arrhythmias and sudden death have been documented in dogs undergoing stereotactic body radiation therapy for heart base tumours. A study was proposed to interrogate the effect of different stereotactic-like radiation prescriptions on RIHD development, including arrhythmogenesis and classical histological endpoints in a mouse model. Read More

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http://dx.doi.org/10.1002/vms3.303DOI Listing

X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.

J Nanobiotechnology 2020 Jun 10;18(1):87. Epub 2020 Jun 10.

ARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, NSW, 2052, Australia.

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis. Read More

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http://dx.doi.org/10.1186/s12951-020-00644-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288491PMC
June 2020
4.078 Impact Factor

CT-guided radiofrequency ablation of osteoid osteoma: established concepts and new ideas.

Br J Radiol 2020 Jun 24:20200266. Epub 2020 Jun 24.

Department of Radiology and Imaging, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Osteoid osteoma is a painful benign bone tumour of children and young adults with characteristic clinico-radiological features depending upon the location of the lesion. Intraoperative visualisation of the nidus is difficult and therefore curative surgery is often associated with excessive bone removal, significant perioperative morbidity and potential need of bone grafting procedures. With advancement in cross-sectional imaging and radiofrequency ablation (RFA) technology, CT-guided RFA has emerged as the treatment of choice for the osteoid osteoma. Read More

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http://dx.doi.org/10.1259/bjr.20200266DOI Listing

Exploring Biologic Correlates of Cancer-Related Fatigue in Men With Prostate Cancer: Cell Damage Pathways and Oxidative Stress.

Biol Res Nurs 2020 Jun 9:1099800420933347. Epub 2020 Jun 9.

Symptom Biology Unit, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.

The pathobiology of cancer-related fatigue (CRF) remains elusive, hindering the development of targeted treatments. Radiation therapy (RT), a common treatment for men with prostate cancer, induces cell damage through the generation of free radicals and oxidative stress. We hypothesized that disruption in cellular responses to this surge of nonphysiological oxidative stress might contribute to CRF in men with prostate cancer treated with RT. Read More

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http://dx.doi.org/10.1177/1099800420933347DOI Listing

Evaluation of Diagnostic Accuracy Following the Coadministration of Delta-Aminolevulinic Acid and Second Window Indocyanine Green in Rodent and Human Glioblastomas.

Mol Imaging Biol 2020 Jun 8. Epub 2020 Jun 8.

Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Purpose: Fluorescence-guided-surgery offers intraoperative visualization of neoplastic tissue. Delta-aminolevulinic acid (5-ALA), which targets enzymatic abnormality in neoplastic cells, is the only approved agent for fluorescence-guided neurosurgery. More recently, we described Second Window Indocyanine Green (SWIG) which targets neoplastic tissue through enhanced vascular permeability. Read More

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http://dx.doi.org/10.1007/s11307-020-01504-wDOI Listing

Feasibility study on equine acellular pericardium matrix (APM): A new tool for breast reconstruction.

J Plast Reconstr Aesthet Surg 2020 May 19. Epub 2020 May 19.

Ca' Foncello Hospital, ULSS2 Marca Trevigiana, via S. Ambrogio di Fiera, n. 37, 31100, Treviso, Italy.

The advent of acellular dermal matrix (ADM) for lower pole coverage allows immediate reconstructions with improved aesthetic outcomes and faster recovery. This study describes for the first time, the use of a new acellular pericardium matrix (APM) in implant-based breast reconstruction and characterises its safety profile. Equity is a membrane with a natural cross-linked structure with many of the properties of ADMs, but improved resistance and reduced thickness. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.05.013DOI Listing

Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model.

Carbohydr Polym 2020 Aug 26;241:116284. Epub 2020 Apr 26.

Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 08308, Republic of Korea. Electronic address:

Gradual wear and tear can cause a local inflammatory response in tendons. The trauma and inflammatory reaction eventually impair the biomechanical properties of the tendon. In this study, we prepared lactoferrin-immobilized, heparin-anchored, poly(lactic-co-glycolic acid) nanoparticles (LF/Hep-PLGA NPs) and evaluated their in vitro anti-inflammatory effects on interleukin-1β (IL-1β)-treated tenocytes and in vivo tendon healing effects in a rat model of Achilles tendinitis. Read More

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http://dx.doi.org/10.1016/j.carbpol.2020.116284DOI Listing

The effect of preoperative radiotherapy on local control and prognosis in high-grade non-metastatic intramedullary osteosarcoma of the extremities.

Arch Orthop Trauma Surg 2020 Jun 6. Epub 2020 Jun 6.

Cerrahpasa Medical Faculty, Department of Radiation Oncology, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Introduction: This study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated with neoadjuvant chemotherapy and limb-salvage surgery.

Materials And Methods: Osteosarcoma patients who referred to our clinic from 1998 to 2015 were investigated retrospectively. 141 patients with non-metastatic osteosarcoma of the limb who received neoadjuvant chemotherapy and underwent limb-sparing surgery with or without preoperative radiotherapy were included in the study. Read More

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http://dx.doi.org/10.1007/s00402-020-03494-4DOI Listing

Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis.

Cancer Lett 2020 Jun 3;489:9-18. Epub 2020 Jun 3.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, FC7.2000, Unit Number: 442, Houston, TX, 77030, USA. Electronic address:

Stereotactic Radiosurgery has become the main treatment for patients with limited number of brain metastases (BM). Recently, with the increasing use of this modality, there is a growth in recurrence cases. Recurrence after radiation therapy can be divided in changes favoring either tumor recurrence or radiation necrosis (RN). Read More

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http://dx.doi.org/10.1016/j.canlet.2020.05.014DOI Listing

Early life-threating enlargement of a vestibular schwannoma after gamma knife radiosurgery.

Acta Neurochir (Wien) 2020 Jun 6. Epub 2020 Jun 6.

Department of Biomedical, Metabolic and Neural Sciences, Neurosurgery Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.

Stereotactic gamma knife radiosurgery (GKS) may induce a transient enlargement of vestibular schwannomas (VS). This phenomenon, known as pseudoprogression or swelling, starts at about 3 months following GKS, peaks at about 6 months, and typically subsides thereafter, usually without significant neurological deterioration. We describe a 34-year-old female who developed an aggressive enlargement of a VS 1 month after GKS. Read More

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http://dx.doi.org/10.1007/s00701-020-04434-2DOI Listing