12,326 results match your criteria Radiation Necrosis


PECAM-1 modulates liver damage induced by synergistic effects of TNF-α and irradiation.

J Cell Mol Med 2019 Feb 14. Epub 2019 Feb 14.

Clinic for Gastroenterology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.

The mechanisms of radiation-induced liver damage are poorly understood. We investigated if tumour necrosis factor (TNF)-α acts synergistically with irradiation, and how its activity is influenced by platelet endothelial cell adhesion molecule-1 (PECAM-1). We studied murine models of selective single-dose (25 Gy) liver irradiation with and without TNF-α application (2 μg/mouse; i. Read More

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http://dx.doi.org/10.1111/jcmm.14224DOI Listing
February 2019

Development and Characterization of a Rabbit Model of Compromised Maxillofacial Wound Healing.

Tissue Eng Part C Methods 2019 Feb 12. Epub 2019 Feb 12.

The University of Texas Health Science Center at Houston, Oral & Maxillofacial Surgery, Houston, Texas, United States ;

Introduction: Tissue engineering technologies aiming to enhance maxillofacial wound healing are often tested in vivo in pre-clinical models that do not necessarily reflect the complexity of the clinical need. The aim of this study was to develop a rabbit model of compromised craniofacial wound healing that more accurately mimics clinical scenarios.

Materials And Methods: An experimental group of rabbits (n= 10) received fractionated radiation of the mandible totaling 36 Gy. Read More

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http://dx.doi.org/10.1089/ten.TEC.2018.0361DOI Listing
February 2019

Stereotactic radiosurgery with concurrent lapatinib is associated with improved local control for HER2-positive breast cancer brain metastases.

J Neurosurg 2019 Feb 8:1-9. Epub 2019 Feb 8.

Departments of1Radiation Oncology and.

OBJECTIVEWith increasing survival for patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer in the trastuzumab era, there is an increased risk of brain metastasis. Therefore, there is interest in optimizing intracranial disease control. Lapatinib is a small-molecule dual HER2/epidermal growth factor receptor inhibitor that has demonstrated intracranial activity against HER2+ breast cancer brain metastases. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182340DOI Listing
February 2019
2 Reads

Raman spectroscopy for the evaluation of the radiobiological sensitivity of normal human breast cells at different time points after irradiation by a clinical proton beam.

Analyst 2019 Feb 8. Epub 2019 Feb 8.

Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, 71122 Foggia, Italy. and Istituto Nazionale di Fisica Nucleare - Sezione di Bari, 70126 Bari, Italy.

Among different radiotherapy techniques, proton irradiation is an established and effective method for treatment of several types of cancer, because less healthy tissue is exposed with respect to conventional radiotherapy by photons/electrons. Recently, proton therapy has been proposed for the treatment of breast cancer. In vitro studies of proton irradiated normal human breast cells can provide information about cellular radioresponse, particularly as far as healthy tissue is concerned. Read More

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http://dx.doi.org/10.1039/c8an02155dDOI Listing
February 2019

Effect of internal mammary vessels radiation dose on outcomes of free flap breast reconstruction.

Breast J 2019 Feb 8. Epub 2019 Feb 8.

Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina.

To assess the impact of internal mammary (IM) vessels radiation dose on autologous free-flap based breast reconstruction outcomes. We retrospectively evaluated the medical records of breast cancer patients who underwent mastectomy and free-flap breast reconstruction after postoperative radiation therapy (RT) to the breast/chest wall with (n = 9) or without (n = 11) electively including the IM lymph nodes. Twenty patients were included. Read More

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http://dx.doi.org/10.1111/tbj.13202DOI Listing
February 2019

Disorder in Pixel-Level Edge Directions on T1WI Is Associated with the Degree of Radiation Necrosis in Primary and Metastatic Brain Tumors: Preliminary Findings.

AJNR Am J Neuroradiol 2019 Feb 7. Epub 2019 Feb 7.

From the Department of Biomedical Engineering (P.P., A.M., P.T.), Case Western Reserve University, Cleveland, Ohio.

Background And Purpose: Co-occurrence of local anisotropic gradient orientations (COLLAGE) is a recently developed radiomic (computer extracted) feature that captures entropy (measures the degree of disorder) in pixel-level edge directions and was previously shown to distinguish predominant cerebral radiation necrosis from recurrent tumor on gadolinium-contrast T1WI. In this work, we sought to investigate whether COLLAGE measurements from posttreatment gadolinium-contrast T1WI could distinguish varying extents of cerebral radiation necrosis and recurrent tumor classes in a lesion across primary and metastatic brain tumors.

Materials And Methods: On a total of 75 gadolinium-contrast T1WI studies obtained from patients with primary and metastatic brain tumors and nasopharyngeal carcinoma, the extent of cerebral radiation necrosis and recurrent tumor in every brain lesion was histopathologically defined by an expert neuropathologist as the following: 1) "pure" cerebral radiation necrosis; 2) "mixed" pathology with coexistence of cerebral radiation necrosis and recurrent tumors; 3) "predominant" (>80%) cerebral radiation necrosis; 4) predominant (>80%) recurrent tumor; and 5) pure tumor. Read More

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http://dx.doi.org/10.3174/ajnr.A5958DOI Listing
February 2019
1 Read

Bevacizumab treatment for radiation brain necrosis: mechanism, efficacy and issues.

Mol Cancer 2019 Feb 7;18(1):21. Epub 2019 Feb 7.

Department of Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, TX77054, USA.

Vascular damage is followed by vascular endothelial growth factor (VEGF) expression at high levels, which is an important mechanism forradiation brain necrosis development. Bevacizumab alleviates brain edema symptoms caused by radiation brain necrosis through inhibiting VEGF and acting on vascular tissue around the brain necrosis area. Many studies have confirmed that bevacizumab effectively relieves symptoms caused by brain necrosis, improves patients' Karnofsky performance status (KPS) scores and brain necrosis imaging. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0950-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367784PMC
February 2019
1 Read

Radiological diagnosis of brain radiation necrosis after cranial irradiation for brain tumor: a systematic review.

Radiat Oncol 2019 Feb 6;14(1):28. Epub 2019 Feb 6.

Department of Neurosurgery, Osaka Medical College, 2-7, Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.

Introduction: This systematic review aims to elucidate the diagnostic accuracy of radiological examinations to distinguish between brain radiation necrosis (BRN) and tumor progression (TP).

Methods: We divided diagnostic approaches into two categories as follows-conventional radiological imaging [computed tomography (CT) and magnetic resonance imaging (MRI): review question (RQ) 1] and nuclear medicine studies [single photon emission CT (SPECT) and positron emission tomography (PET): RQ2]-and queried. Our librarians conducted a comprehensive systematic search on PubMed, the Cochrane Library, and the Japan Medical Abstracts Society up to March 2015. Read More

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http://dx.doi.org/10.1186/s13014-019-1228-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364413PMC
February 2019
1 Read

Stereotactic radiosurgery with concurrent HER2-directed therapy is associated with improved objective response for breast cancer brain metastasis.

Neuro Oncol 2019 Feb 6. Epub 2019 Feb 6.

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.

Background: Patients with breast cancer positive for human epidermal growth factor receptor 2 (HER2) remain at high risk of intracranial relapse following treatment and experience increased rates of intracranial failure after stereotactic radiosurgery (SRS). We hypothesized that the addition of concurrent lapatinib to SRS would improve intracranial complete response rates.

Methods: Patients with newly diagnosed HER2-amplified breast cancer brain metastases from 2005-2014 who underwent SRS were included and divided into 2 cohorts based on timing of treatment with lapatinib. Read More

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http://dx.doi.org/10.1093/neuonc/noz006DOI Listing
February 2019
2 Reads

Metformin attenuates hypoxia-induced resistance to cisplatin in the HepG2 cell line.

Oncol Lett 2019 Feb 24;17(2):2431-2440. Epub 2018 Dec 24.

Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.

Hepatoblastoma is the most commonly occurring liver tumor in children. Preoperative chemotherapy and surgery have improved treatment outcomes; however, further improvements are required in the treatment of advanced cases. Recently, the efficacy of transarterial chemoembolization (TACE) has garnered attention. Read More

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http://dx.doi.org/10.3892/ol.2018.9869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350205PMC
February 2019

Patient-Reported Satisfaction and Quality of Life in Postmastectomy Radiated Patients: A Comparison between Delayed and Delayed Immediate Autologous Breast Reconstruction in a Predominantly Minority Patient Population.

J Reconstr Microsurg 2019 Feb 4. Epub 2019 Feb 4.

Division of Plastic Surgery, Montefiore Medical Center, Bronx, New York.

Background:  Delayed immediate (DI) autologous breast reconstruction consists of immediate postmastectomy tissue expander placement, radiation therapy, and subsequent autologous reconstruction. The decision between timing of reconstructive methods is challenging and remains to be elucidated. We aim to compare patient reported outcomes and quality of life between delayed and DI reconstruction. Read More

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http://dx.doi.org/10.1055/s-0039-1677798DOI Listing
February 2019

Pressure induced tissue resection in the larynx: A preliminary canine study.

Laryngoscope 2019 Feb 4. Epub 2019 Feb 4.

Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, U.S.A.

Objectives: The application of laser (light amplification by stimulated emission of radiation) energy in the larynx relies on thermal injury. The impact of this injury on adjacent tissue can be undesirable. Attempts have been made to limit the extent and range of injury to adjacent tissue. Read More

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http://dx.doi.org/10.1002/lary.27822DOI Listing
February 2019

Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China.

Med Gas Res 2018 Oct-Dec;8(4):135-143. Epub 2019 Jan 9.

Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Cognitive and Mental Health Research Center, Beijing, China.

Expending a considerable amount of physical energy inevitably leads to fatigue during both training and competition in football. An increasing number of experimental findings have confirmed the relationship between the generation and clearance of free radicals, fatigue, and exercise injury. Recently, hydrogen was identified as a new selective antioxidant with potential beneficial applications in sports. Read More

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http://www.medgasres.com/text.asp?2018/8/4/135/248263
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http://dx.doi.org/10.4103/2045-9912.248263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352569PMC
January 2019
5 Reads

The use of laser speckle contrast imaging to predict flap necrosis: An experimental study in a porcine flap model.

J Plast Reconstr Aesthet Surg 2019 Jan 3. Epub 2019 Jan 3.

Department of Hand and Plastic Surgery and Burns and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background: We evaluated the use of laser speckle contrast imaging (LSCI) in the perioperative planning in reconstructive flap surgery. The aim of the study was to investigate whether LSCI can predict regions with a high risk of developing postoperative necrosis. Our hypothesis was that, perioperatively, such regions have perfusion values below a threshold value and show a negative perfusion trend. Read More

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http://dx.doi.org/10.1016/j.bjps.2018.11.021DOI Listing
January 2019

Radiation-induced thoracic necrosis with a pulmonary cutaneous fistula repaired using a free omental flap: a case report.

BMC Surg 2019 Feb 2;19(1):14. Epub 2019 Feb 2.

Department of Plastic Surgery, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama, 359-0042, Japan.

Background: Chest wall necrosis can manifest as a late effect of radiation therapy for breast cancer. Only two cases of fistulas communicating with the respiratory tract as a result of radiation-induced necrosis of the lungs or bronchi have been reported. To the best of our knowledge, we report the first case of a pulmonary cutaneous fistula arising as a late effect of radiation therapy for breast cancer, which was successfully repaired using a free omental graft. Read More

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https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-01
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http://dx.doi.org/10.1186/s12893-019-0479-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360029PMC
February 2019
4 Reads

PC 12 Pheochromocytoma Cell Response to Super High Frequency Terahertz Radiation from Synchrotron Source.

Cancers (Basel) 2019 Jan 31;11(2). Epub 2019 Jan 31.

School of Science, RMIT University, P.O. Box 2476, Melbourne, VIC 3001, Australia.

High frequency (HF) electromagnetic fields (EMFs) have been widely used in many wireless communication devices, yet within the terahertz (THz) range, their effects on biological systems are poorly understood. In this study, electromagnetic radiation in the range of 0.3⁻19. Read More

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http://dx.doi.org/10.3390/cancers11020162DOI Listing
January 2019
1 Read

Alleviation of Ultraviolet-B Radiation-Induced Photoaging by a TNFR Antagonistic Peptide, TNFR2-SKE.

Mol Cells 2019 Jan 23. Epub 2019 Jan 23.

Department of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 24341, Korea.

Ultraviolet (UV) radiation of the sunlight, especially UVA and UVB, is the primary environmental cause of skin damage, including topical inflammation, premature skin aging, and skin cancer. Previous reports show that activation of nuclear factor-κB (NF-κB) in human skin fibroblasts and keratinocytes after UV exposure induces the expression and release of proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α), and subsequently leads to the production of matrix metalloproteases (MMPs) and growth factor basic fibroblast growth factor (bFGF). Here, we demonstrated that TNFR2-SKEE and TNFR2-SKE, oligopeptides from TNF receptor-associated factor 2 (TRAF2)-binding site of TNF receptor 2 (TNFR2), strongly inhibited the interaction of TNFR1 as well as TNFR2 with TRAF2. Read More

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http://dx.doi.org/10.14348/molcells.2018.0423DOI Listing
January 2019

CCR2-dependent recruitment of Tregs and monocytes following radiotherapy is associated with TNFα-mediated resistance.

Cancer Immunol Res 2019 Jan 29. Epub 2019 Jan 29.

CIMI, Inserm.

Radiation therapy (RT) represents one of the main anti-cancer approaches for the treatment of solid tumors. Beyond the expected direct effects of RT on tumor cells, evidence supporting the importance of an immune response to radiotherapy is growing. The balance between RT-mediated immunogenic and tolerogenic activity is ill-defined and deserves more attention. Read More

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0633DOI Listing
January 2019
7 Reads

Impact of Radiotherapy Concurrent with Anti-PD-1 Therapy on the Lung Tissue of Tumor-Bearing Mice.

Radiat Res 2019 Jan 29. Epub 2019 Jan 29.

a   Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Pneumonitis is a common adverse effect found in non-small cell lung cancer patients after radiotherapy or immune checkpoint inhibitor treatment. We investigated the effects of these two therapies, combined, in the lung tissue of an orthotopic tumor-bearing mouse model. The mice received an 8 Gy dose three times with or without 200 μg anti-programmed death-1 (anti-PD-1) antibody intraperitoneal injection every three days. Read More

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http://www.rrjournal.org/doi/10.1667/RR15182.1
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http://dx.doi.org/10.1667/RR15182.1DOI Listing
January 2019
11 Reads

Anti-inflammatory effects of chemical components from Ginkgo biloba L. male flowers on lipopolysaccharide-stimulated RAW264.7 macrophages.

Phytother Res 2019 Jan 29. Epub 2019 Jan 29.

Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijng, China.

Ginkgo biloba L., well known as living fossil, have various pharmacological activities. Eighteen compounds were isolated from Ginkgo male flowers including a novel matsutake alcohol glycoside, Ginkgoside A (1), and 17 known compounds-calaliukiuenoside (2), benzylalcohol O-α-l-arabinopyranosyl-(1 → 6)-β-d-glucopyranoside (3), amentoflavone (4), sciadopitysin (5), bilobetin (6), isoginkgetin (7), olivil 4-O-β-d-glucopyranoside (8), dihydrodehydrodiconiferyl alcohol-4-O-β-d-glucoside (9), (+)-cyclo-olivil-6-O-β-d-glucopyranoside (10), (-)-isolariciresinol 4-O-β-d-glucopyranoside (11), coniferin (12), trans-cinnamic acid-4-O-β-d-glucopyranoside (13), p-coumaryl alchol glucoside (14), stroside B (15), methylconiferin (16), cis-p-coumaric acid 4-O-β-d-glucopyranoside (17), and cis-coniferin (18). Read More

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http://dx.doi.org/10.1002/ptr.6292DOI Listing
January 2019
3 Reads

Prognostic Characterization of Higher-Grade Meningiomas: A Histopathological Score to Predict Progression and Outcome.

J Neuropathol Exp Neurol 2019 Jan 25. Epub 2019 Jan 25.

Pathology Unit, Department of Medical Sciences, University of Turin, Torino, Italy.

Higher-grade meningiomas (WHO grade II and III) represent a diagnostic and prognostic challenge. We assessed the pathological and molecular characteristics of 94 higher-grade meningiomas (85 grade II, 9 grade III) to identify novel prognostic parameters. Higher mitotic count (p = 0. Read More

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http://dx.doi.org/10.1093/jnen/nly127DOI Listing
January 2019

[Reduced radiation-induced brain necrosis in nasopharyngeal cancer patients with bevacizumab monotherapy].

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Klinik für Strahlentherapie & Ambulanzzentrum Strahlentherapie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01425-wDOI Listing
January 2019

Outcomes Following Proton Therapy for Pediatric Low-Grade Glioma.

Int J Radiat Oncol Biol Phys 2019 Jan 23. Epub 2019 Jan 23.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL.

Background/objectives: Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is the 4th most common pediatric tumor treated with proton therapy, yet clinical outcome data on efficacy and toxicity are limited.

Design/methods: We reviewed the medical records of 174 children (≤21 years old) with non-metastatic LGG enrolled on a prospective protocol and treated with proton therapy between 2007 and 2017 to assess clinical outcomes and toxicity, and analyze patient, tumor, and treatment-related variables. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.01.078DOI Listing
January 2019
15 Reads

Persistent disparities in breast cancer surgical outcomes among hispanic and African American patients.

Eur J Surg Oncol 2019 Jan 17. Epub 2019 Jan 17.

Yale School of Medicine, Department of Surgery, Section of Plastic and Reconstructive Surgery, New Haven, CT, USA. Electronic address:

Background: Racial disparities among patients who receive breast mastectomy and reconstruction have not been well characterized.

Methods: Records of patients undergoing breast extirpative and reconstructive surgery at a high-volume university-affiliated hospital over 5 consecutive years were reviewed. Patient demographics, breast cancer profiles, reconstructive modality, and outcomes were compared by race. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.016DOI Listing
January 2019
12 Reads

Neoadjuvant chemotherapy for radiation-associated soft-tissue sarcoma: A case report.

Rare Tumors 2019 6;11:2036361318821763. Epub 2019 Jan 6.

Diagnostic Radiology, Keck Medical Center, University of Southern California, Los Angeles, CA, USA.

Radiation-associated sarcomas are rare and aggressive types of sarcomas that can occur after exposure to ionizing radiation. We examine a case of radiation-associated undifferentiated/unclassified soft-tissue sarcoma with primary disease in the chest wall. The optimal treatment of these patients is surgical resection if possible; however, the role of chemotherapy has not been well defined. Read More

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http://dx.doi.org/10.1177/2036361318821763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327331PMC
January 2019

Protective effect of MAAs extracted from Porphyra tenera against UV irradiation-induced photoaging in mouse skin.

J Photochem Photobiol B 2018 Dec 19;192:26-33. Epub 2018 Dec 19.

College of Food Science and Engineering, Ocean University of China, No.5, Yu Shan Road, Qingdao, Shandong Province 266003, PR China.

The objective of this study was to investigate the effect of Mycosporine-like amino acids (MAAs) extracted from Porphyra tenera skin against UV irradiation-induced photoaging using an ICR mouse model of skin photoaging and to explore the curative effects of the compounds in MAAs. The skin damage and collagenous tissue impairments induced by ultraviolet radiation were observed by histopathological analysis, and the effects of MAAs on protecting against skin damage and maintaining an intact structure of collagenous tissue were studied. The expression of NF-κB and the MAPK signaling pathway and nuclear transcription factors MMP-1, MMP-3 and TNF-α was analyzed used quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) and ELISA assays. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.12.009DOI Listing
December 2018

Vitamin D improves sunburns by increasing autophagy in M2 macrophages.

Autophagy 2019 Jan 21:1-14. Epub 2019 Jan 21.

a Department of Dermatology , Case Western Reserve University School of Medicine , Cleveland , OH , USA.

Cutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate tissue destruction. Recovery is mediated chiefly by anti-inflammatory M2 macrophages that suppress inflammation and augment epidermal regeneration. Vitamin D enables anti-inflammation to promote tissue repair in response to injury. Read More

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http://dx.doi.org/10.1080/15548627.2019.1569298DOI Listing
January 2019
1 Read

Overall survival and response to radiation and targeted therapies among patients with renal cell carcinoma brain metastases.

J Neurosurg 2019 Jan 18:1-9. Epub 2019 Jan 18.

Departments of1Radiation Oncology and.

OBJECTIVEThe object of this retrospective study was to investigate the impact of targeted therapies on overall survival (OS), distant intracranial failure, local failure, and radiation necrosis among patients treated with radiation therapy for renal cell carcinoma (RCC) metastases to the brain.METHODSAll patients diagnosed with RCC brain metastasis (BM) between 1998 and 2015 at a single institution were included in this study. The primary outcome was OS, and secondary outcomes included local failure, distant intracranial failure, and radiation necrosis. Read More

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http://dx.doi.org/10.3171/2018.8.JNS182100DOI Listing
January 2019
1 Read

Effects of silica-rich water on systemic and peritoneal inflammation in rats exposed to chronic low-level (900-MHz) microwave radiation.

Gen Physiol Biophys 2019 Jan 18;38(1):83-90. Epub 2019 Jan 18.

Department of Pathophysiology, Faculty of Medicine, University of Niš, Niš, Serbia.

Immunomodulating effect of silica-rich water represents a novel field for research, especially regarding its features toward environmental pollutants. The aim of our study was to evaluate the effects of silica-rich water intake on systemic and peritoneal inflammation in rats that were chronically exposed to the low-level microwave (MW) radiation from mobile phones. Wistar Albino rats were exposed to 900 MHz MW radiation for 3 months. Read More

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http://dx.doi.org/10.4149/gpb_2018032DOI Listing
January 2019

Laser-interstitial thermal therapy compared to craniotomy for treatment of radiation necrosis or recurrent tumor in brain metastases failing radiosurgery.

J Neurooncol 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.

Purpose: Many publications report laser-interstitial thermal therapy (LITT) as a viable alternative treatment to craniotomy for radiation necrosis (RN) and re-growing tumor occurring after stereotactic radiosurgery (SRS) for brain metastases. No studies to-date have compared the two options. The aim of this study was to retrospectively compare outcomes after LITT versus craniotomy for regrowing lesions in patients previously treated with SRS for brain metastases. Read More

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http://link.springer.com/10.1007/s11060-019-03097-z
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http://dx.doi.org/10.1007/s11060-019-03097-zDOI Listing
January 2019
6 Reads
3.070 Impact Factor

Tumor-infiltrating T-cell Receptor-beta Repertoires are Linked to the Risk of Late Chemoradiation-induced Temporal Lobe Necrosis in Locally Advanced Nasopharyngeal Carcinoma.

Int J Radiat Oncol Biol Phys 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiation Oncology, Koo Foundation Sun-Yat-Sen Cancer Center, Taipei, Taiwan. Electronic address:

Purpose: Temporal lobe necrosis (TLN), a late complication of nasopharyngeal carcinoma (NPC) after concurrent chemoradiotherapy (CCRT), causes permanent neurological deficits. We aimed to investigate the risk factors for the development of CCRT-induced TLN in locally advanced NPC patients.

Methods And Materials: The incidence of CCRT-induced TLN was assessed in consecutive NPC patients initially staged with TNM receiving curative intensity-modulated radiotherapy (IMRT) and cisplatin-based chemotherapy with long-term follow-up. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193003
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http://dx.doi.org/10.1016/j.ijrobp.2019.01.002DOI Listing
January 2019
4 Reads

Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):24-29. Epub 2018 Aug 11.

Internal Medicine Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt.

Obesity is the main determinant of type 2 diabetes. Some adipocytokines play important roles in diabetic complications. Lipid transport is an important aspect of lipid metabolism in cancer. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.08.005DOI Listing

Rechallenge capecitabine after fluoropyrimidine-induced cardiotoxicity in rectal cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14057

Rationale: Fluoropyrimidine-induced cardiotoxicity is a rare but potentially serious toxicity. The most common symptom is anginal chest pain.

Patient Concerns: A 35-year-old woman was diagnosed with rectal cancer with metastasis to the liver. Read More

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http://dx.doi.org/10.1097/MD.0000000000014057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336628PMC
January 2019
1 Read

Quantitative Metastatic Lymph Node Regions on Magnetic Resonance Imaging Are Superior to AJCC N Classification for the Prognosis of Nasopharyngeal Carcinoma.

J Oncol 2018 2;2018:9172585. Epub 2018 Dec 2.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Purpose: Quantitative lymph node burden has been demonstrated to be a critical prognosticator in various malignancies, yet it was seldom explored in nasopharyngeal carcinoma (NPC). This study aimed to investigate the impact of the number of metastatic lymph node regions (LRN) on prognosis of NPC and to establish a new N classification system based on LRN.

Methods And Materials: The magnetic resonance images (MRI) of 354 nondisseminated NPC patients before radical treatment were retrospectively evaluated. Read More

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http://dx.doi.org/10.1155/2018/9172585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304546PMC
December 2018
1 Read

Toxicity Evaluation of a Novel Magnetic Resonance Imaging Marker, CoCl2-N-Acetylcysteine, in Rats.

J Toxicol 2018 2;2018:9173452. Epub 2018 Dec 2.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, USA.

C4 (cobalt dichloride-N-acetylcysteine [1% CoCl:2% NAC]) is a novel magnetic resonance imaging contrast marker that facilitates visualization of implanted radioactive seeds in cancer brachytherapy. We evaluated the toxicity of C4. Rats were assigned to control (0% CoCl:NAC), low-dose (0. Read More

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https://www.hindawi.com/journals/jt/2018/9173452/
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http://dx.doi.org/10.1155/2018/9173452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304599PMC
December 2018
4 Reads

Radiation Necrosis, Pseudoprogression, Pseudoresponse, and Tumor Recurrence: Imaging Challenges for the Evaluation of Treated Gliomas.

Contrast Media Mol Imaging 2018 2;2018:6828396. Epub 2018 Dec 2.

Department of Radiology, University Hospital of Ioannina, Ioannina, Greece.

Glioblastoma (GBM) is the most common primary malignant type of brain neoplasm in adults and carries a dismal prognosis. The current standard of care for GBM is surgical excision followed by radiation therapy (RT) with concurrent and adjuvant temozolomide-based chemotherapy (TMZ) by six additional cycles. In addition, antiangiogenic therapy with an antivascular endothelial growth factor (VEGF) agent has been used for recurrent glioblastoma. Read More

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http://dx.doi.org/10.1155/2018/6828396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305027PMC
December 2018

Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy.

Nanoscale 2019 Jan;11(4):1710-1719

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou, 510631, China.

Microwave irradiation is a powerful non-invasive approach for treating deep-seated diseases in a clinical setting. Pulsed microwave-induced thermoacoustic cavitation allows precise cancer treatment with microwave-absorbing materials. This differs from the traditional continuous microwave-induced thermotherapy which may be harmful to off-target tissues. Read More

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http://xlink.rsc.org/?DOI=C8NR08498J
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http://dx.doi.org/10.1039/c8nr08498jDOI Listing
January 2019
8 Reads

Pathologic Features of Tumor Activity and Stability in Uveal Melanoma Specimens after Fractionated CyberKnife Radiosurgery.

Pathol Oncol Res 2019 Jan 7. Epub 2019 Jan 7.

Department of Ophthalmology, University Medical Center Rostock, Doberaner Str. 140, 18057, Rostock, Germany.

To evaluate uveal melanoma cell activity and pathologic features after stereotactic CyberKnife radiosurgery in specimens from five patients. Specimens from five patients treated by CyberKnife radiosurgery in three fractions were included in this study. Because of persistent retinal detachment in 3 patients, tumour endoresection was performed at four, seven and ten month after CyberKnife radiosurgery. Read More

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http://link.springer.com/10.1007/s12253-018-00565-1
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http://dx.doi.org/10.1007/s12253-018-00565-1DOI Listing
January 2019
5 Reads

The "Dual-Plane" DIEP Flap: Measuring the Effects of Superficial Arterial and Venous Flow Augmentation on Clinical Outcomes.

J Reconstr Microsurg 2019 Jan 7. Epub 2019 Jan 7.

Division of Plastic and Reconstructive Surgery, University of California San Francisco, San Francisco, California.

Background:  Deep inferior epigastric perforator (DIEP) flaps are routinely elevated on a single dominant perforator from the deep epigastric vascular system. However, the single perforator may not always perfuse an entire flap adequately, particularly suprascarpal tissue. We often perform "dual-plane" single perforator DIEP flaps by rerouting the superficial (SIEA/V) system directly into a branch of the deep (DIEA/V) vascular system pedicle, thus allowing both systems to contribute and enhance flap perfusion. Read More

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http://dx.doi.org/10.1055/s-0038-1677013DOI Listing
January 2019

Prospective comparative diagnostic accuracy evaluation of dynamic contrast-enhanced (DCE) vs. dynamic susceptibility contrast (DSC) MR perfusion in differentiating tumor recurrence from radiation necrosis in treated high-grade gliomas.

J Magn Reson Imaging 2019 Jan 5. Epub 2019 Jan 5.

University of Ottawa, Ottawa, Ontario, Canada.

Background: The appearance of a new enhancing lesion after surgery and chemoradiation for high-grade glioma (HGG) presents a common diagnostic dilemma. Histopathological analysis remains the reference standard in this situation.

Purpose: To prospectively compare the diagnostic accuracy of dynamic contrast-enhanced (DCE) vs. Read More

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http://dx.doi.org/10.1002/jmri.26621DOI Listing
January 2019
2 Reads

In Vitro and In Vivo Protective Effects of Flavonoid-Enriched Lotus Seedpod Extract on Lipopolysaccharide-Induced Hepatic Inflammation.

Am J Chin Med 2019 Jan 7:1-23. Epub 2019 Jan 7.

* Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan.

Endotoxin lipopolysaccharide (LPS) plays an important role in the acceleration of hepatic inflammation. Natural medicinal plants that can prevent inflammation by targeting LPS have potential therapeutic clinical application. The aim of the study is to examine the anti-inflammatory effects of lotus seedpod extract (LSE), used as a traditional Chinese herbal medicine with hemostasis function and for eliminating bruise, on the LPS-induced hepatic inflammation and its underlying molecular mechanisms in vitro and in vivo. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X195
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http://dx.doi.org/10.1142/S0192415X19500083DOI Listing
January 2019
11 Reads

Autopsy report of a late delayed radiation injury after a period of 45 years.

Neuropathology 2019 Jan 4. Epub 2019 Jan 4.

Faculty of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

For delayed radiation injury, image analysis has considerably advanced, but neuropathological findings are still required to establish diagnosis. A patient who had received radiation therapy for pineal germinoma at age 14 developed neurological and psychiatric abnormalities after 15 years as a late delayed radiation injury. Autopsy at age 59 revealed diffuse changes in the white matter consisting in order of severity of myelin pallor, demyelination, and necrosis which were characterized by a lack of glial reaction. Read More

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http://doi.wiley.com/10.1111/neup.12528
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http://dx.doi.org/10.1111/neup.12528DOI Listing
January 2019
7 Reads

Clinical outcomes of limb salvage surgery with postoperative intensity-modulated radiation therapy for soft-tissue sarcoma and metastasis.

Indian J Cancer 2018 Apr-Jun;55(2):176-178

Department of Orthopaedic Surgery, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.

Objective: The primary aim of intensity-modulated radiation therapy (IMRT) for treating soft tissue sarcoma of an extremity is the reduction of morbidity and maintenance of local control.

Methods: We evaluated the outcomes and toxicity of adjuvant IMRT following function-preserving surgery to treat patients with soft tissue sarcoma and metastasis of the extremities. We retrospectively reviewed prospective databases at Kure Medical Center and Aichi Medical University between 2013 and 2016 and identified 10 patients with lower extremity soft tissue sarcoma who underwent both limb-sparing surgery and postoperative IMRT at one of our institutions. Read More

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http://dx.doi.org/10.4103/ijc.IJC_618_17DOI Listing
January 2019
2 Reads

Treatment outcomes with whole-field versus split-field intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma.

Head Neck 2018 Dec 31. Epub 2018 Dec 31.

Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: The purpose of this study was to present our comparison of the clinical outcome of patients with nasopharyngeal carcinoma (NPC) treated with whole-field intensity-modulated radiotherapy (whole-field-IMRT) or split-field-IMRT.

Methods: We retrospectively studied 388 patients with M0 NPC. The median lower neck doses were 50 Gy in 1. Read More

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http://dx.doi.org/10.1002/hed.25328DOI Listing
December 2018
1 Read

Stereotactic Radiosurgery for Multiple Brain Metastases From Renal-Cell Carcinoma.

Clin Genitourin Cancer 2018 Nov 22. Epub 2018 Nov 22.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX.

Background: Brain metastases (BM) pose a significant problem in patients with metastatic renal-cell carcinoma (mRCC). Local and systemic therapies including stereotactic radiosurgery (SRS) are rapidly evolving, necessitating reassessments of outcomes for modern patient management.

Patients And Methods: The mRCC patients with BM treated with SRS were reviewed. Read More

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http://dx.doi.org/10.1016/j.clgc.2018.11.006DOI Listing
November 2018
5 Reads
1.693 Impact Factor

The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α.

Free Radic Biol Med 2018 Dec 26;134:1-8. Epub 2018 Dec 26.

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536 USA, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

Cancer treatments are developing fast and the number of cancer survivors could arise to 20 million in United State by 2025. However, a large fraction of cancer survivors demonstrate cognitive dysfunction and associated decreased quality of life both shortly, and often long-term, after chemotherapy treatment. The etiologies of chemotherapy induced cognitive impairment (CICI) are complicated, made more so by the fact that many anti-cancer drugs cannot cross the blood-brain barrier (BBB). Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.029DOI Listing
December 2018
1 Read

Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants.

Toxicol Sci 2018 Dec 24. Epub 2018 Dec 24.

Departments of Environmental and Occupational Health, School of Public Health, Rutgers University, Piscataway, NJ, USA.

A diverse group of toxicants has been identified that cause injury to the lung including gases (e.g., ozone, chlorine), particulate matter (e. Read More

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https://academic.oup.com/toxsci/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/toxsci/kfy309DOI Listing
December 2018
4 Reads

Prognostic Value and Staging Classification of Lymph Nodal Necrosis in Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy.

Cancer Res Treat 2018 Dec 27. Epub 2018 Dec 27.

Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.

Purpose: The aim of the present study was to evaluate the prognostic value of magnetic resonance imaging (MRI)‒determined lymph nodal necrosis (LNN) in nasopharyngeal carcinoma (NPC) and explore the feasibility of an N-classification system based on the 8th edition of the American Joint Committee on Cancer (AJCC) system.

Materials And Methods: The MRI scans of 616 patients with newly diagnosed stage T1-4N1-3M0 NPC who were treated with definitive intensity-modulated radiotherapy (IMRT) were reviewed.

Results: Multivariate analysis showed that LNN was an independent negative prognostic predictor of distant metastasis free survival (hazard ratio, 1. Read More

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http://dx.doi.org/10.4143/crt.2018.595DOI Listing
December 2018

Risk Factors for Recurrence of Malignant Phyllodes Tumors of the Breast.

In Vivo 2019 Jan-Feb;33(1):263-269

Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background/aim: In this study, the treatment outcome and risk factors for recurrence in patients undergoing surgery with or without adjuvant radiotherapy (RT) for malignant phyllodes tumors of the breast (MPTB) were analyzed.

Patients And Methods: Forty-three patients (61.4%) underwent breast-conserving surgery (BCS) and 27 (38. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11470
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http://dx.doi.org/10.21873/invivo.11470DOI Listing
October 2018
6 Reads

The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.

Acta Neuropathol 2019 Feb 24;137(2):307-319. Epub 2018 Dec 24.

Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.

Meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is a rare tumor with propensity for recurrence and metastasis. Although multiple classification schemes have been proposed, optimal risk stratification remains unclear, and the prognostic impact of fusion status is uncertain. We compared the 2016 WHO CNS tumor grading scheme (CNS-G), a three-tier system based on histopathologic phenotype and mitotic count, to the 2013 WHO soft-tissue counterpart (ST-G), a two-tier system based on mitotic count alone, in a cohort of 133 patients [59 female, 74 male; mean age 54 years (range 20-87)] with meningeal SFT/HPC. Read More

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http://link.springer.com/10.1007/s00401-018-1952-6
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http://dx.doi.org/10.1007/s00401-018-1952-6DOI Listing
February 2019
7 Reads