15,881 results match your criteria Radiation Necrosis


Fractionated pre-operative stereotactic radiotherapy for patients with brain metastases: a multi-institutional analysis.

J Neurooncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Radiation Oncology, The Ohio State University Wexner Medical Center, 460 W. 10th Avenue, Columbus, OH, 43210, USA.

Background: The current standard of care for patients with a large brain metastasis and limited intracranial disease burden is surgical resection and post-operative single fraction stereotactic radiosurgery (SRS). However, post-operative SRS can still lead to substantial rates of local failure (LF), radiation necrosis (RN), and meningeal disease (MD). Pre-operative SRS may reduce the risk of RN and MD, while fractionated treatments may improve local control by allowing delivery of higher biological effective dose. Read More

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Endoscopic surgery is superior to intensity modulated radiotherapy in the treatment of advanced recurrent nasopharyngeal carcinoma.

Int Forum Allergy Rhinol 2022 Jun 24. Epub 2022 Jun 24.

ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Background: The choice between endoscopic surgery and re-radiotherapy as the main treatment modality in patients with advanced recurrent nasopharyngeal carcinoma (rNPC) remains controversial. Therefore, in this study, we compared the efficacies of endoscopic surgery and intensity-modulated radiotherapy (IMRT) in patients with rNPC.

Methods: All patients with advanced rNPC (T3 and T4) who underwent salvage treatment were enrolled from January 2009 to December 2020. Read More

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Bevacizumab is an effective treatment for symptomatic cerebral necrosis after carbon ion therapy for recurrent intracranial malignant tumours: A case report.

Mol Clin Oncol 2022 Jul 19;17(1):114. Epub 2022 May 19.

The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Carbon ion therapy (CIT) is a form of particle therapy, which not only spares normal tissues but may also improve local control of recurrent intracranial tumours. Cerebral radiation necrosis (RN) is one of the most serious adverse reactions of recurrent brain tumours following reirradiation, which may lead to neurological decline or even death. Bevacizumab is an anti-vascular endothelial growth factor antibody, which has been used to treat symptomatic RN. Read More

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Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis-A Literature Review.

Pharmaceutics 2022 Jun 6;14(6). Epub 2022 Jun 6.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.

Radiotherapy is an integral part of modern oncology, applied to more than half of all patients diagnosed with cancer. It can be used alone or in combination with surgery or chemotherapy. However, despite the high precision of radiation delivery, irradiation may affect surrounding healthy tissues leading to the development of toxicity. Read More

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Interventional Radiology in the Management of Metastases and Bone Tumors.

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

San Salvatore Hospital, 67100 L'Aquila, Italy.

Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc. Read More

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The Value of FET PET/CT in Recurrent Glioma with a Different IDH Mutation Status: The Relationship between Imaging and Molecular Biomarkers.

Int J Mol Sci 2022 Jun 17;23(12). Epub 2022 Jun 17.

Experimental Particle Physics Department, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.

The evaluation of treatment response remains a challenge in glioma cases because the neuro oncological therapy can lead to the development of treatment-related changes (TRC) that mimic true progression (TP). Positron emission tomography (PET) using O-(2-[F] fluoroethyl-)-L-tyrosine (F-FET) has been shown to be a useful tool for detecting TRC and TP. We assessed the diagnostic performance of different F-FET PET segmentation approaches and different imaging biomarkers for differentiation between late TRC and TP in glioma patients. Read More

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Pulsed-Reduced Dose Rate (PRDR) Radiotherapy for Recurrent Primary Central Nervous System Malignancies: Dosimetric and Clinical Results.

Cancers (Basel) 2022 Jun 15;14(12). Epub 2022 Jun 15.

Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA.

Purpose: The objective was to describe PRDR outcomes and report EQD2 OAR toxicity thresholds.

Methods: Eighteen patients with recurrent primary CNS tumors treated with PRDR at a single institution between April 2017 and September 2021 were evaluated. The radiotherapy details, cumulative OAR doses, progression-free survival (PFS), overall survival (OS), and toxicities were collected. Read More

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Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling.

Biomedicines 2022 Jun 10;10(6). Epub 2022 Jun 10.

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Acute pancreatitis (AP) poses a worldwide challenge due to the growing incidence and its potentially life-threatening course and complications. Specific targeted therapies are not available, prompting the identification of new pathways and novel therapeutic approaches. Flavonoids comprise several groups of biologically active compounds with wide-ranging effects. Read More

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Radiation-induced osteoradionecrosis of the ribs in a patient with breast cancer: A case report.

Radiol Case Rep 2022 Aug 13;17(8):2894-2898. Epub 2022 Jun 13.

Department of Radiology, Yeungnam University College of Medicine, Daegu, Republic of Korea.

Osteoradionecrosis of the chest wall after radiation therapy for breast cancer is rare; however, it is one of the most severe complications of radiation treatment. Radiologically, osteoradionecrosis can manifest as a focal lucent area in bone, periostitis, sclerosis, and cortical irregularity of bones on X-ray or computed tomography; therefore, differentiation from bone metastasis can be challenging. Associated insufficiency fractures, ulceration, and skin necrosis may also occur. Read More

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Optimal Timing of Delayed Microvascular Breast Reconstruction after Radiation Therapy.

J Reconstr Microsurg 2022 Jun 17. Epub 2022 Jun 17.

Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

Background:  The purpose of this study was to determine the optimal timing of delayed microvascular breast reconstruction after completion of postmastectomy radiation therapy (PMRT). The authors evaluated whether the timing of reconstruction after PMRT completion affects the development of major postoperative complications. We hypothesize that delayed microvascular breast reconstruction can be safely performed within 12 months of PMRT completion. Read More

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It is beneficial to invest resources to implement proton intracranial SRS.

J Appl Clin Med Phys 2022 Jun 17:e13701. Epub 2022 Jun 17.

Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona, USA.

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Distinguishing Tumor Admixed in a Radiation Necrosis (RN) Background: H and H MR With a Novel Mouse Brain-Tumor/RN Model.

Front Oncol 2022 30;12:885480. Epub 2022 May 30.

Department of Radiology, Washington University, Saint Louis, MO, United States.

Purpose: Distinguishing radiation necrosis (RN) from recurrent tumor remains a vexing clinical problem with important health-care consequences for neuro-oncology patients. Here, mouse models of pure tumor, pure RN, and admixed RN/tumor are employed to evaluate hydrogen (H) and deuterium (H) magnetic resonance methods for distinguishing RN vs. tumor. Read More

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Radiosynoviorthesis, almost 70 years of experience but still somewhat fameless.

Q J Nucl Med Mol Imaging 2022 Jun 16. Epub 2022 Jun 16.

Department of Nuclear Medicine, Northwest Clinics, Alkmaar, The Netherlands.

Radiosynoviorthesis (RSO) or radiation synovectomy has been practiced for more than half a century, but in many parts of the world, it is still relatively unknown and not used to its full potential in the standard care for chronic, persistent or recurrent synovitis. The working mechanism of RSO is simple yet elegant. Radiopharmaceutical particles are, after injection in the affected synovial joint, gobbled up by phagocytizing subsynovial inflammatory cells. Read More

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The early infiltrative phase of GBM hypothesis: are molecular glioblastomas histological glioblastomas in the making? A preliminary multicenter study.

J Neurooncol 2022 Jun 14. Epub 2022 Jun 14.

Division Chair, Neuro-Oncology, Department of Neurology, Mayo Clinic, Florida, 4500 San Pablo Rd. S, Jacksonville, FL, 32224, USA.

Purpose: The presence of necrosis or microvascular proliferation was previously the hallmark for glioblastoma (GBM) diagnosis. The 2021 WHO classification now considers IDH-wildtype diffuse astrocytic tumors without the histological features of glioblastoma (that would have otherwise been classified as grade 2 or 3) as molecular GBM (molGBM) if they harbor any of the following molecular abnormalities: TERT promoter mutation, EGFR amplification, or chromosomal + 7/-10 copy changes. We hypothesize that these tumors are early histological GBM and will eventually develop the classic histological features. Read More

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Radioprotective Effect of (Rosemary) Essential Oil on Apoptosis, Necrosis and Mitotic Death of Human Peripheral Lymphocytes (PBMCs).

J Biomed Phys Eng 2022 Jun 1;12(3):245-256. Epub 2022 Jun 1.

PhD, Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Rosemary plant, with phenolic compounds, is known as an antioxidant herb and able to scavenge free radical agents in the biological environment; therefore, it is expected that the rosemary essential oil (R-EO) shows the radioprotective effect to protect individuals who are physically in contact with ionizing radiation.

Objective: This study aimed to assess the radioprotective effect of R-EO on human peripheral blood mononuclear cells (PBMCs).

Material And Methods: In this experimental study, the toxicity of the rosemary essential oil on PBMCs was assessed by the 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. Read More

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Suppression of NF-κB signaling by ECN in an arthritic model of inflammation.

BMC Complement Med Ther 2022 Jun 13;22(1):158. Epub 2022 Jun 13.

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Background: The 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid isolated from the Tussilago farfara Linneaus (Asteraceae), was evaluated against acute Carrageenan and chronic complete Freund's adjuvant (CFA)-induced arthritis in mice.

Methods: Acute and chronic arthritis were induced by administering Carrageenan and CFA to the intraplantar surface of the mouse paw. Edema, mechanical allodynia, mechanical hyperalgesia, and thermal hyperalgesia were assessed in the paw. Read More

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The role of cesium-131 brachytherapy in brain tumors: a scoping review of the literature and ongoing clinical trials.

J Neurooncol 2022 Jun 13. Epub 2022 Jun 13.

Department of Radiation Oncology, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra, New York, NY, USA.

Purpose: Cesium-131 radioactive isotope has favored the resurgence of intracavitary brachytherapy in neuro-oncology, minimizing radiation-induced complications and maximizing logistical and clinical outcomes. We reviewed the literature on cesium-131 brachytherapy for brain tumors.

Methods: PubMed, Web-of-Science, Scopus, Clinicaltrial. Read More

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Delayed [18F]-FDG PET Imaging Increases Diagnostic Performance and Reproducibility to Differentiate Recurrence of Brain Metastases From Radionecrosis.

Clin Nucl Med 2022 Jun 10. Epub 2022 Jun 10.

Department of Nuclear Medicine. Montpellier University Hospital. PYMEDEXP, University of Montpellier, INSERM, CNRS, Montpellier, France.

Purpose: Differentiating brain metastasis recurrence from radiation necrosis can be challenging during MRI follow-up after stereotactic radiotherapy. [18F]-FDG is the most available PET tracer, but standard images performed 30 to 60 minutes postinjection provide insufficient accuracy. We compared the diagnostic performance and interobserver agreement of [18F]-FDG PET with delayed images (4-5 hours postinjection) with the ones provided by standard and dual-time-point imaging. Read More

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Dynamic F-FET PET/CT to differentiate recurrent primary brain tumor and brain metastases from radiation necrosis after single-session robotic radiosurgery.

Cancer Treat Res Commun 2022 Jun 3;32:100583. Epub 2022 Jun 3.

Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany; Department of Nuclear Medicine, University Hospital of Ulm, Ulm 89070, Germany. Electronic address:

Objective: Cyberknife robotic radiosurgery (RRS) provides single-session high-dose radiotherapy of brain tumors with a steep dose gradient and precise real-time image-guided motion correction. Although RRS appears to cause more radiation necrosis (RN), the radiometabolic changes after RRS have not been fully clarified. F-FET-PET/CT is used to differentiate recurrent tumor (RT) from RN after radiosurgery when MRI findings are indecisive. Read More

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Neoadjuvant Radiation in High-Grade Soft-Tissue Sarcomas: Histopathologic Features and Response Evaluation.

Am J Surg Pathol 2022 Jun 3. Epub 2022 Jun 3.

Institute of Pathology, Technical University of Munich.

In this study, we sought to determine the prognostic value of both the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) score and the histologic parameters viable tumor, coagulative necrosis, hyalinization/fibrosis, and infarction in patients (n=64) with localized, nonmetastatic high-grade soft-tissue sarcomas after preoperative radiomonotherapy. A standardized macroscopic workup for pretreated surgical specimen including evaluation of a whole section of high-grade soft tissue sarcomas in the largest diameter, was used. Association with overall survival and disease-free survival was assessed. Read More

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Divergent white matter changes in patients with nasopharyngeal carcinoma post-radiotherapy with different outcomes: a potential biomarker for prediction of radiation necrosis.

Eur Radiol 2022 Jun 10. Epub 2022 Jun 10.

Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518052, China.

Objectives: To investigate the effects of standard radiotherapy on temporal white matter (WM) and its relationship with radiation necrosis (RN) in patients with nasopharyngeal carcinoma (NPC), and to determine the predictive value of WM volume alterations at the early stage for RN occurrence at the late-delay stage.

Methods: Seventy-four treatment-naive NPC patients treated with standard radiotherapy were longitudinally followed up for 36 months. Structural MRIs were collected at multiple time points during the first year post-radiotherapy. Read More

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Cardioprotective Effect of Linn. Leaf Extract against Catecholamine-Induced Cardiotoxicity.

Molecules 2022 May 24;27(11). Epub 2022 May 24.

Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.

(L.) is a folklore medicinal herb that has been used for centuries to cure cardiovascular diseases. The present work was carefully designed to ascertain the pharmacological basis for 's therapeutic efficacy in cardiovascular diseases, as well as the underlying mechanism. Read More

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The Antithrombotic Effect of Recombinant Neorudin on Thrombi.

Drug Des Devel Ther 2022 2;16:1667-1678. Epub 2022 Jun 2.

Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.

Introduction: Recombinant neorudin (EPR-hirudin, EH) was developed through the addition of an EPR (Glu-Pro-Arg) peptide to the amino terminus of hirudin, which can be recognized and cut by coagulation factors XIa (FXIa) and/or Xa (FXa). In this study, the low-bleeding antithrombotic effects of EH were evaluated utilizing experimental models of thrombosis in rabbits and rats to provide a test basis for clinical trials.

Methods: The bleeding risks of EH and hirudin were first compared in mice by the tail-clipping method, and then the antithrombotic activity of EH was investigated in a rabbit model of arteriovenous bypass thrombosis and a rat model of thrombotic cerebral infarction. Read More

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Detailed analyses of the impact of multimodal cancer therapy with hyperthermia and radiotherapy on the immune phenotype of human glioblastoma cells.

Int J Hyperthermia 2022 ;39(1):796-805

Translational Radiobiology, Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Purpose: Improvements of heat-delivery systems have led to hyperthermia (HT) being increasingly recognized as an adjunct treatment modality also for brain tumors. But how HT affects the immune phenotype of glioblastoma cells is only scarcely known.

Materials And Methods: We therefore investigated the effect of HT, radiotherapy (RT), and the combination of both (RHT) on cell death modalities, immune checkpoint molecule (ICM) expression and release of the danger signal HSP70 of two human glioblastoma cell lines (U87 and U251) by using multicolor flow cytometry and ELISA. Read More

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The Influence of the Pretreatment Immune State on Response to Radiation Therapy in High Risk Prostate Cancer: A Validation Study from NRG/RTOG 0521.

Int J Radiat Oncol Biol Phys 2022 Jun 5. Epub 2022 Jun 5.

UCSF Medical Center, Department of Radiation Oncology.

Purpose/objectives: The immuno-inflammatory state has been shown to be associated with poor outcomes following radiation therapy (RT). We conducted an a priori designed validation study using serum specimens from RTOG 0521. It was hypothesized the pre-treatment inflammatory state would correlate with clinical outcomes. Read More

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Protective effect of extract against hepatic fibrosis induced by Gamma irradiation and carbon tetrachloride in albino rats.

Int J Radiat Biol 2022 Jun 22:1-11. Epub 2022 Jun 22.

Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.

Purpose: Liver fibrosis is considered as one of the ultimate outcomes of chronic liver disorders, characterized by outrageous cell proliferation and abnormal deposition of extracellular matrix, resulting in sever pathological distortions in the architecture and performance of liver tissues. The present study aimed to investigate the protective properties of aqueous methanol extract of leaves (AFL) against liver fibrosis induced by dual toxicity of γ-irradiation and carbon tetrachloride (CCl) in rats.

Methods: The animals were exposed to 2 Gy irradiation once/week concurrently with intraperitoneal administration of CCl (0. Read More

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Novel Imaging Biomarkers to Assess Oncologic Treatment-Related Changes.

Am Soc Clin Oncol Educ Book 2022 Apr;42:1-13

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.

Cancer therapeutics cause various treatment-related changes that may impact patient follow-up and disease monitoring. Although atypical responses such as pseudoprogression may be misinterpreted as treatment nonresponse, other changes, such as hyperprogressive disease seen with immunotherapy, must be recognized early for timely management. Radiation necrosis in the brain is a known response to radiotherapy and must be distinguished from local tumor recurrence. Read More

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Systemic Therapy Type and Timing Effects on Radiation Necrosis Risk in HER2+ Breast Cancer Brain Metastases Patients Treated With Stereotactic Radiosurgery.

Front Oncol 2022 20;12:854364. Epub 2022 May 20.

Duke Center for Brain and Spine Metastasis, Duke Cancer Institute, Duke University Medical Center, Durham, NC, United States.

Background: There is a concern that HER2-directed systemic therapies, when administered concurrently with stereotactic radiosurgery (SRS), may increase the risk of radiation necrosis (RN). This study explores the impact of timing and type of systemic therapies on the development of RN in patients treated with SRS for HER2+ breast cancer brain metastasis (BCBrM).

Methods: This was a single-institution, retrospective study including patients >18 years of age with HER2+ BCBrM who received SRS between 2013 and 2018 and with at least 12-month post-SRS follow-up. Read More

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Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles.

Sci Rep 2022 Jun 3;12(1):9271. Epub 2022 Jun 3.

Department of Physics, K. N. Toosi University of Technology, Shariati, Tehran, 15875-4416, Iran.

This paper studies the effectiveness of the integration of microwave field irradiation and laser emission in liver cancer therapy with the aid of gold nanorods, in order to find out the influences of these combinational methods in tumor necrosis. Hepatocellular carcinoma is a kind of liver cancer that usually has a complicated structure, including both of superficial and deep sections. In current research, in deep regions of cancerous tissue, microwave antenna is utilized and in superficial regions, laser beams are irradiated. Read More

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Commentary: Evaluating potential glioma serum biomarkers, with future applications.

World J Clin Oncol 2022 May;13(5):412-416

Department of Neurosurgery, University of Florida, Gainesville, FL 32608, United States.

Systemic inflammation within malignant glioma is a topic of ongoing significance. In this commentary, we highlight recent findings from Gandhi and discuss alternative approaches. We present a counter argument with findings that IL-6 markers are controversial. Read More

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