12,453 results match your criteria Radiation Necrosis


Feasibility of Re-irradiation using carbon ions for recurrent head and neck malignancies after carbon-ion radiotherapy.

Radiother Oncol 2019 Apr 19;136:148-153. Epub 2019 Apr 19.

Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Background And Purpose: Locoregional recurrence after carbon-ion radiotherapy (CIRT) for primary head and neck malignancies, such as malignant mucosal melanoma, adenoid cystic carcinoma, and sarcoma, occurs occasionally. However, the treatment options are limited. We report on the toxicity and efficacy of re-irradiation using carbon ions for recurrent head and neck malignancies after CIRT. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.04.007DOI Listing

Long-term Clinical Outcomes and Safety Profile of SBRT for Centrally Located NSCLC.

Adv Radiat Oncol 2019 Apr-Jun;4(2):422-428. Epub 2019 Jan 24.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: Previous studies suggest that stereotactic body radiation therapy (SBRT) is associated with higher toxicity rates for central lung tumors relative to peripheral tumors when using 3 fraction SBRT. The initial results from Radiation Therapy Oncology Group study 0813 suggest a safe toxicity profile of SBRT administered in 5 fractions for central non-small cell lung cancer (NSCLC). We reviewed our institutional data to evaluate the safety and efficacy of SBRT for central NSCLC. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460233PMC
January 2019

Quantitative temporal diffusion spectroscopy as an early imaging biomarker of radiation therapeutic response in gliomas: A preclinical proof of concept.

Adv Radiat Oncol 2019 Apr-Jun;4(2):367-376. Epub 2018 Nov 20.

Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee.

Purpose: This study aims to test the ability of quantitative temporal diffusion spectroscopy (qTDS) to assess cellular changes associated with radiation-induced cell death in a rat glioma model.

Methods And Materials: Tumor response to a single fraction of 20 Gy of x-ray radiation was investigated in a rat glioma (9L) model. Tumor response was monitored longitudinally at postinoculation days 21, 23, and 25, using a specific implementation of qTDS with acronym IMPULSED (Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion), as well as conventional diffusion and high-resolution anatomic imaging. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460331PMC
November 2018

Improved Model Prediction of Glioma Growth Utilizing Tissue-Specific Boundary Effects.

Math Biosci 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Mayo Clinic, Phoenix, AZ, USA.

Kinetic parameter estimates for mathematical models of glioblastoma multiforme (GBM), derived from clinical scans, have been used to predict the occurrence of hypoxia, necrosis, response to radiation therapy, and overall survival. Modeling GBM growth in a cerebral model encounters anatomical boundaries that interfere with model calibration from clinical measurements.

Methods: The effect of boundaries is examined on both spherically symmetric and anatomical models of tumor growth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00255564173060
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http://dx.doi.org/10.1016/j.mbs.2019.04.004DOI Listing
April 2019
1 Read

Heterogeneity of Magnetic Resonance Imaging Apparent Diffusion Coefficient Signal in Radiation Necrosis.

Clin Oncol (R Coll Radiol) 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India.

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http://dx.doi.org/10.1016/j.clon.2019.04.005DOI Listing

Multicenter Phase II Study of Intraoperative Radiotherapy of Early Breast Cancer: Ipsilateral Tumor Recurrence.

Ann Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Background: We performed a multicenter phase II study on the efficacy and safety of intraoperative radiotherapy (IORT) as partial breast irradiation using multiple devices.

Methods: The primary endpoint was ipsilateral breast tumor recurrence (IBTR). Key inclusion criteria were T < 2. Read More

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http://dx.doi.org/10.1245/s10434-019-07350-7DOI Listing
April 2019
5 Reads

Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy.

NPJ Breast Cancer 2019 10;5:13. Epub 2019 Apr 10.

1Department of Radiation Biology, Institute for Cancer Research, Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway.

Currently the greatest challenge in oncology is the lack of homogeneity of the lesions where different cell components respond differently to treatment. There is growing consensus that monotherapies are insufficient to eradicate the disease and there is an unmet need for more potent combinatorial treatments. We have previously shown that hypericin photodynamic therapy (HYP-PDT) triggers electron transport chain (ETC) inhibition in cell mitochondria. Read More

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http://dx.doi.org/10.1038/s41523-019-0108-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458138PMC
April 2019
1 Read

DCE and DSC perfusion MRI diagnostic accuracy in the follow-up of primary and metastatic intra-axial brain tumors treated by radiosurgery with cyberknife.

Radiat Oncol 2019 Apr 15;14(1):65. Epub 2019 Apr 15.

Neuroradiology Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Italy.

Background: The differential diagnosis between radiation necrosis, tumor recurrence and tumor progression is crucial for the evaluation of treatment response and treatment planning. The appearance of treatment-induced tissue necrosis on conventional Magnetic Resonance Imaging (MRI) is similar to brain tumor recurrence and it could be difficult to differentiate the two entities on follow-up MRI examinations. Dynamic Susceptibility Contrast-enhanced (DSC) and Dynamic Contrast-Enhanced (DCE) are MRI perfusion techniques that use an exogenous, intravascular, non-diffusible gadolinium-based contrast agent. Read More

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http://dx.doi.org/10.1186/s13014-019-1271-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466652PMC

Efficacy and Tolerance of Post-operative Hypo-Fractionated Stereotactic Radiotherapy in a Large Series of Patients With Brain Metastases.

Front Oncol 2019 28;9:184. Epub 2019 Mar 28.

Academic Department of Radiation Oncology, Centre Oscar Lambret, University Lille II, Lille, France.

The aim of this study was to assess, in a large series, the efficacy and tolerance of post-operative adjuvant hypofractionated stereotactic radiation therapy (HFSRT) for brain metastases (BMs). Between July 2012 and January 2017, 160 patients from 2 centers were operated for BM and treated by HFSRT. Patients had between 1 and 3 BMs, no brainstem lesions or carcinomatous meningitis. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00184/
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http://dx.doi.org/10.3389/fonc.2019.00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448411PMC
March 2019
2 Reads

Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc Monocytes in Rectal Cancer.

Front Immunol 2019 29;10:602. Epub 2019 Mar 29.

Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Neoadjuvant radiochemotherapy (nRCT) can significantly influence the tumor immune architecture that plays a pivotal role in regulating tumor growth. Whereas, various studies have investigated the effect of nRCT on tumor-infiltrating T cells, little is known about its impact on the frequency and activation status of human dendritic cells (DCs). Plasmacytoid DCs (pDCs) essentially contribute to the regulation of innate and adaptive immunity and may profoundly influence tumor progression. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450462PMC
March 2019
1 Read

Stereotactic radiosurgery combined with nivolumab or Ipilimumab for patients with melanoma brain metastases: evaluation of brain control and toxicity.

J Immunother Cancer 2019 Apr 11;7(1):102. Epub 2019 Apr 11.

IRCCS Neuromed, 86077, Pozzilli (IS), Italy.

Purpose: To investigate the efficacy and safety of concurrent stereotactic radiosurgery (SRS) and ipilimumab or nivolumab in patients with untreated melanoma brain metastases.

Patients And Methods: Eighty consecutive patients with 326 melanoma brain metastases receiving SRS in combination with ipilimumab or nivolumab were identified from an institutional database and retrospectively evaluated. Patients started systemic treatment with intravenous nivolumab or ipilimumab within one week of receiving SRS. Read More

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http://dx.doi.org/10.1186/s40425-019-0588-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458744PMC

A series of in vitro and human studies of a novel lip cream formulation for protecting against environmental triggers of recurrent herpes labialis.

Clin Cosmet Investig Dermatol 2019 22;12:193-208. Epub 2019 Mar 22.

AVR Consulting, Ltd., Cheshire, UK.

Purpose: These studies describe the testing of a novel, daily-use lip cream designed for individuals with lips prone to recurrent herpes labialis (RHL) that protects against environmental triggers.

Subjects And Methods: In vitro occlusive and in vitro and in vivo photoprotection analyses, a characterization of normal vs dry lips, and a randomized, evaluator-blinded, clinical trial that assessed the lip cream in healthy subjects with dry lips were conducted. In the clinical trial, subjects applied the lip cream or were untreated and evaluated using transepidermal water loss (TEWL), corneometry, visual assessments of lip dryness, expert photographic evaluations, and subject-rated outcomes. Read More

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http://dx.doi.org/10.2147/CCID.S179430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432897PMC
March 2019
1 Read

Efficacy and Safety of Hypofractionated Stereotactic Radiotherapy for Recurrent Malignant Gliomas: A Systematic Review and Meta-analysis.

World Neurosurg 2019 Apr 5. Epub 2019 Apr 5.

Deparment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China; No. 1 South 1 Section First-ring RD, Chengdu, China. Electronic address:

Background: The current treatment for patients with relapsed malignant glioma (MG) remains unsatisfactory. Utilization of hypofractionated stereotactic radiotherapy (HFSRT) for recurrent malignant glioma has shown some encouraging results and may be a proper option.

Material And Methods: We performed a systematic review and meta-analysis of publications which investigated the use of HFSRT for recurrent MG. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193097
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http://dx.doi.org/10.1016/j.wneu.2019.03.297DOI Listing
April 2019
3 Reads

Dependency of the blood oxygen level dependent-response to hyperoxic challenges on the order of gas administration in intracranial malignancies.

Neuroradiology 2019 Apr 4. Epub 2019 Apr 4.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Purpose: Literature reports contradicting results on the response of brain tumors to vascular stimuli measured in T2*-weighted MRI. Here, we analyzed the potential dependency of the MRI-response to (hypercapnic) hyperoxia on the order of the gas administration.

Methods: T2* values were quantified at 3 Tesla in eight consenting patients at rest and during inhalation of hyperoxic/hypercapnic gas mixtures. Read More

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http://dx.doi.org/10.1007/s00234-019-02200-5DOI Listing
April 2019
2 Reads

Long-term glioblastoma survival following recovery from cytomegalovirus colitis: A case report.

J Clin Neurosci 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States; Lou and Jean Malnati Brain Tumor Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States. Electronic address:

Survival outcomes for patients with glioblastoma (GBM) are universally poor with only a small percentage of patients surviving five years beyond initial diagnosis. Activation of the immune system against tumor cells is the basis of immunotherapy and aims to facilitate long-term immune surveillance and tumor suppression. Cytomegalovirus (CMV) has emerged as an immunologic target in GBM given that tumor cells have been shown to express the CMV-associated proteins IE1 and pp65. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868193036
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http://dx.doi.org/10.1016/j.jocn.2019.03.051DOI Listing
April 2019
2 Reads

RNA-Seq analysis revealed genes associated with UV-induced cell necrosis through MAPK/TNF-α pathways in human dermal fibroblast cells as an inducer of premature photoaging.

Genomics 2019 Apr 1. Epub 2019 Apr 1.

Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia; Institute of Plantation Studies, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia. Electronic address:

Exposing the skin to solar UV radiation induces cascades of signaling pathways and biological alterations such as redox imbalance, suppression of antioxidant genes and programmed cell death. Therefore, the aim of this study was to use RNA-Seq to unravel the effects of UV radiation on Normal Human Adult Fibroblast cells (NHDF). Cells were exposed to UV (20 mJ/cm2 for 3 mins) and incubated for 24 h. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08887543183065
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http://dx.doi.org/10.1016/j.ygeno.2019.03.011DOI Listing
April 2019
1 Read

A novel chrysin derivative produced by gamma irradiation attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in Balb/c mice.

Food Chem Toxicol 2019 Apr 1;128:223-232. Epub 2019 Apr 1.

Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 29, Geumgu-gil, Jeongup, Jeongbuk, 56212, Republic of Korea. Electronic address:

Gamma irradiation is a useful technology to change the physical and biological properties of natural molecules. In this study, we investigated whether gamma irradiation improve properties of chrysin as an anti-inflammatory candidates. Chrysin was converted into two compounds (CM1 and CM2) by gamma irradiation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193017
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http://dx.doi.org/10.1016/j.fct.2019.03.048DOI Listing
April 2019
5 Reads

Optimization of the adipose-derived mesenchymal stem cell delivery time for radiation-induced lung fibrosis treatment in rats.

Sci Rep 2019 Apr 3;9(1):5589. Epub 2019 Apr 3.

Department of Experimental Pharmacology and Toxicology, Pharmaceutical Science of Jilin University, Changchun, Jilin, 130021, China.

The present study attempts to identify the optimal time duration for the administration of Ad-MSCs, in order to maximize its therapeutic benefits, and compare the degree of fibrosis among three different administration time points using the RILF rat model system. Ad-MSCs were delivered to Sprague-Dawley rats through the tail vein at the following different time points after thorax irradiation: two hours, seven days, and two hours + seven days. Post Ad-MSCs transplantation and the histopathological analysis of the lungs were performed along with analysis of inflammatory cytokine levels, including interleukin (IL)-1, IL-2, IL-6, IL-10 and tumor necrosis factor-α (TNF-α). Read More

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http://dx.doi.org/10.1038/s41598-019-41576-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447528PMC
April 2019
2 Reads

TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways.

Oncol Rep 2019 Jun 2;41(6):3305-3312. Epub 2019 Apr 2.

Center for Genomic Integrity Institute for Basic Science (IBS), Ulsan National Institute of Science and Technology, Ulsan 689‑798, Republic of Korea.

Histone H2B monoubiquitination has been shown to play critical roles in diverse cellular processes including DNA damage response. Although recent data indicate that H2B monoubiquitination is strongly connected with tumor progression and regulation, the implications of this modification in lung adenocarcinoma are relatively unknown. In the present study, we demonstrated the clinical implication of H2B monoubiquitination and the potential role of tumor necrosis factor receptor‑associated factor‑interacting protein (TRAIP) in regulating its modification in lung adenocarcinoma. Read More

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http://dx.doi.org/10.3892/or.2019.7092DOI Listing
June 2019
4 Reads

Crocin mitigates γ-rays-induced hepatic toxicity in rats.

Environ Sci Pollut Res Int 2019 Apr 2. Epub 2019 Apr 2.

Egyptian Atomic Energy Authority, P. O. Box 29, Nasr City, Cairo, Egypt.

Crocin (CHO) is an isolated bioactive molecule of saffron extract. It has different pharmacological effects such as antioxidant and anti-inflammatory activities. In the present study, radioprotective property of crocin was investigated in the rat liver. Read More

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http://dx.doi.org/10.1007/s11356-019-04724-yDOI Listing
April 2019
1 Read

Investigating the diagnostic value of quantitative parameters based on T2-weighted and contrast-enhanced MRI with psoas muscle and outer myometrium as internal references for differentiating uterine sarcomas from leiomyomas at 3T MRI.

Cancer Imaging 2019 Apr 1;19(1):20. Epub 2019 Apr 1.

The University of Sydney, Discipline of Medical Imaging and Radiation Sciences, Image Optimisation and Perception Group (MIOPeG), Sydney, NSW, Australia.

Background: Post-hysterectomy histopathological examination is currently the main diagnostic tool for differentiating uterine sarcomas from leiomyomas. This study aimed to investigate the diagnostic accuracy of preoperative quantitative metrics based on T2-weighted sequences and contrast-enhanced MRI (CE-MRI) for distinguishing uterine sarcomas from leiomyomas.

Materials And Methods: The institutional review board approved the study. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40644-019-0206-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444554PMC
April 2019
6 Reads

Anti-Inflammatory Effects of Catalpalactone Isolated from in LPS-Induced RAW264.7 Cells.

Molecules 2019 Mar 29;24(7). Epub 2019 Mar 29.

Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Korea.

(Bignoniaceae) is widely distributed throughout Korea, China, and Japan. This study investigated the anti-inflammatory effects of catalpalactone isolated from in lipopolysaccharide (LPS)-induced RAW264.7 cells. Read More

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http://dx.doi.org/10.3390/molecules24071236DOI Listing
March 2019
2.416 Impact Factor

Antioxidant and anti-inflammatory constituents from Flos populi.

Nat Prod Res 2019 Mar 31:1-9. Epub 2019 Mar 31.

a Anhui Medical University , Hefei , China.

Investigation of the n-butanol extract of Flos populi led to the isolation of one new phenolic glycoside, 4'-hydroxybenzyl-2-hydroxybenzoate-1'-O-β-D-glucopyranoside (1), together with twelve known compounds, which have been determined on the basis of spectroscopic analysis including UV, IR, HR-ESI-MS and 1D/2D NMR. The antioxidant capacity of all compounds were evaluated by ABTS radical-scavenging test and ferric reducing antioxidant power (FRAP) assay. And during a screening procedure for the anti-inflammatory activities among most compounds on lipopolysaccharide (LPS)-stimulated RAW 264. Read More

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http://dx.doi.org/10.1080/14786419.2019.1586702DOI Listing
March 2019
2 Reads
0.919 Impact Factor

Prognostic value of the mRNA expression of members of the HSP90 family in non-small cell lung cancer.

Exp Ther Med 2019 Apr 31;17(4):2657-2665. Epub 2019 Jan 31.

Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

The aim of the present study was to investigate the potential prognostic value of members of the heat shock protein (HSP)90 family in non-small cell lung cancer (NSCLC) patients. The mRNA expression profiles of 1,926 NSCLC patients, which was available from the Kaplan-Meier plotter database, were included in the study. High expression of HSP90AA1 mRNA was significantly associated with a poorer rate of overall survival (OS) for all NSCLC patients [hazard ratio (HR), 1. Read More

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http://dx.doi.org/10.3892/etm.2019.7228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425268PMC
April 2019
3 Reads

Intrabeam Radiation Inhibits Proliferation, Migration, and Invasiveness and Promotes Apoptosis of MCF-7 Breast Cancer Cells.

Technol Cancer Res Treat 2019 01;18:1533033819840706

1 Breast Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Intraoperative radiotherapy differs from the more commonly used external beam radiation with respect to fractionation, radiation energy, dose rate, and target volume, which may influence the irradiated cells in a complex manner. However, experimental studies of intraoperative radiotherapy are limited. Intrabeam is a frequently used intraoperative radiotherapy device; we evaluated its effects on the proliferation, apoptosis, migration, and invasion of MCF-7 human breast cancer cells. Read More

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http://dx.doi.org/10.1177/1533033819840706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444775PMC
January 2019

Toxicity and clinical outcomes of partial breast irradiation compared to whole breast irradiation for early-stage breast cancer: a systematic review and meta-analysis.

Breast Cancer Res Treat 2019 Mar 30. Epub 2019 Mar 30.

Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St, Petach Tikva, Israel.

Purpose: There is uncertainty about outcomes differences between partial breast irradiation (PBI) and whole breast irradiation (WBI) for early-stage breast cancer.

Methods: Prospective randomized trials comparing adjuvant PBI to WBI in early-stage invasive breast cancer were identified using PubMed. Odds ratios (OR), 95% confidence intervals and absolute risks were computed for pre-specified efficacy and toxicity outcomes including cosmesis. Read More

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http://dx.doi.org/10.1007/s10549-019-05209-9DOI Listing
March 2019
1 Read

Impact of setup and range uncertainties on TCP and NTCP following VMAT or IMPT of oropharyngeal cancer patients.

Phys Med Biol 2019 Apr 23;64(9):095001. Epub 2019 Apr 23.

Department of Radiation Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. Author to whom any correspondence should be addressed.

Setup and range uncertainties compromise radiotherapy plan robustness. We introduce a method to evaluate the clinical effect of these uncertainties on the population using tumor control probability (TCP) and normal tissue complication probability (NTCP) models. Eighteen oropharyngeal cancer patients treated with curative intent were retrospectively included. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1459DOI Listing
April 2019
2 Reads

[CD226 knockout aggravates radiation-induced liver injury in mice].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2019 Jan;35(1):46-51

Department of Immunology, Transplant Immunology Laboratory, School of Basic Medical Sciences, Air Force Military Medical University, Xi'an 710032, China. *Corresponding author, E-mail:

Objective To investigate the effect of CD226 knockout (KO) on radiation-induced liver injury in mice. Methods Wild-type (WT) and CD226KO mice were randomly divided into naive group and irradiated group. The mice in the irradiated group were exposed to an 8 Gy of Co γ-radiation. Read More

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January 2019
1 Read

Pathologic Response to Neoadjuvant Therapy is Associated With Improved Long-term Survival in High-risk Primary Localized Malignant Peripheral Nerve Sheath Tumors.

Am J Clin Oncol 2019 May;42(5):426-431

Departments of Surgery, Division of Surgical Oncology.

Background: Malignant peripheral nerve sheath tumors (MPNSTs) comprise a rare, aggressive subtype of soft tissue sarcoma. While surgery is the mainstay of therapy for this disease, the role of neoadjuvant therapy remains undefined.

Methods: This study reviewed patients 16 years of age and older who underwent surgical treatment for MPNST between 1974 and 2012 at the authors' institution. Read More

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http://dx.doi.org/10.1097/COC.0000000000000536DOI Listing

Personalized re-treatment strategy for uveal melanoma local recurrences after interventional radiotherapy (brachytherapy): single institution experience and systematic literature review.

J Contemp Brachytherapy 2019 Feb 28;11(1):54-60. Epub 2019 Feb 28.

Istituto di Oftalmologia, Università Cattolica del Sacro Cuore, Roma, Italy.

Purpose: To report the results of a patient's tailored therapeutic approach using a second course of interventional radiotherapy (brachytherapy) in patients with locally recurrent uveal melanoma.

Material And Methods: Patients who had already undergone ocular brachytherapy treated at our IOC (Interventional Oncology Center) were considered. Five patients who has received a second course of treatment with a plaque after local recurrences were included in our study. Read More

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http://dx.doi.org/10.5114/jcb.2019.82888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431104PMC
February 2019

Prognostic significance of serum soluble DR5 levels in small-cell lung cancer.

Int J Med Sci 2019 29;16(3):403-408. Epub 2019 Jan 29.

Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China.

The death receptor 5 (DR5) is a member of the tumor necrosis factor receptor superfamily that can transduce the apoptosis signal in cells. This study assessed serum levels of soluble death receptor 5 (sDR5) in small-cell lung cancer (SCLC) patients compared with those in healthy controls. Clinicopathological features of patients, treatment responses, and overall survival of patients were also recorded and analyzed. Read More

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http://dx.doi.org/10.7150/ijms.28814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428977PMC
January 2019

"The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety".

Plast Reconstr Surg 2019 Mar 7. Epub 2019 Mar 7.

Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, Michigan.

Background: Radiotherapy plays an essential role in the oncologic management of breast cancer. However, patients who undergo radiotherapy experience significantly more wound complications during the reconstructive process. Deferoxamine is an FDA-approved iron chelator with immense potential to up-regulate angiogenesis and improve reconstructive outcomes. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005647DOI Listing
March 2019
4 Reads

Characterization of thymoquinone/hydroxypropyl-β-cyclodextrin inclusion complex: Application to anti-allergy properties.

Eur J Pharm Sci 2019 May 20;133:167-182. Epub 2019 Mar 20.

Faculty of Medical Laboratory Sciences, National Ribat University, Khartoum 11111, Sudan.

Thymoquinone is an effective phytochemical compound in the treatment of various diseases. However, its practical administration has been limited due to poor aqueous solubility and bioavailability. In this work, we developed a novel inclusion complex of thymoquinone and hydroxypropyl-β-cyclodextrin that features improved solubility and bioactivity. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.03.015DOI Listing
May 2019
1 Read
3.350 Impact Factor

Extract Protects Mouse Skin from UVB Radiation via Attenuating Collagen Disruption and Inflammation.

Int J Mol Sci 2019 Mar 21;20(6). Epub 2019 Mar 21.

Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Korea.

In recent years, the use of botanical agents to prevent skin damage from solar ultraviolet (UV) irradiation has received considerable attention. is known to exert anti-inflammatory and antioxidant activities. This study investigated photoprotective properties of an extract (OJE) against UVB-induced skin damage in ICR mice. Read More

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http://dx.doi.org/10.3390/ijms20061435DOI Listing

Management of a chronic radiation necrosis wound with lyopreserved placental membrane containing viable cells.

Clin Case Rep 2019 Mar 28;7(3):456-460. Epub 2019 Jan 28.

Osiris Therapeutics, Inc. Columbia Maryland.

This case report describes management of a chronic radiation wound in a patient with multiple comorbidities using a lyopreserved placental membrane containing viable cells (vLPM). Positive outcomes suggest that vLPM provides a good conservative management option for patients with compromised wound healing due to radiation and comorbidities. Read More

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http://dx.doi.org/10.1002/ccr3.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406146PMC

Stereotactic Body Radiotherapy - Current Indications.

Klin Onkol 2019 ;32(1):10-24

Background: Stereotactic body radiotherapy (SBRT) is used to treat localized tumor lesions and consists of applying high doses of radiation to a small number of fractions using specially equipped linear accelerators, modern immobilization devices, and imaging methods, which are considered special, advanced techniques in modern day radiotherapy. SBRT is a very well tolerated, non-invasive, short-term treatment that does not require hospitalization or any complicated preparation. Compared to standard radiotherapy techniques, SBRT allows, due to its precision, significantly higher doses to be applied to the target with less damage to surrounding healthy tissues. Read More

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http://dx.doi.org/10.14735/amko201910DOI Listing
April 2019
1 Read

Clinical Management of Blood⁻Brain Barrier Disruptions after Active Raster-Scanned Carbon Ion Re-Radiotherapy in Patients with Recurrent Head-and-Neck Cancer.

Cancers (Basel) 2019 Mar 19;11(3). Epub 2019 Mar 19.

Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.

The aim of the current evaluation was to assess central nervous system necrosis (CNSN) after re-irradiation with carbon ions (CR) in two-hundred seventeen ( = 217) patients with recurrent head-and-neck cancer (HNC). Thirty-six ( = 36) patients with CNSN were assessed retrospectively regarding clinical symptoms and radiographic response. CNSN were classified according to clinical management in line with the Common Terminology Criteria for Adverse Events (CTCAE) v5. Read More

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http://dx.doi.org/10.3390/cancers11030383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469035PMC

Oncologic outcomes and radiation safety of nipple-sparing mastectomy with intraoperative radiotherapy for breast cancer.

Breast Cancer 2019 Mar 19. Epub 2019 Mar 19.

Department of Breast Surgery, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.

Background: Nipple-sparing mastectomy combined with breast reconstruction helps to optimize the contour of the breast after mastectomy. However, the indications for nipple-sparing mastectomy are still controversial. Local radiation to the nipple-areola complex may play some roles in improving the oncological safety of this procedure. Read More

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http://dx.doi.org/10.1007/s12282-019-00962-7DOI Listing
March 2019
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Association Between Tumor Compartment Volumes, the Incidence of Pretreatment Seizures, and Statin-Mediated Protective Effects in Glioblastoma.

Neurosurgery 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, University Medicine of Rostock, Rostock, Germany.

Background: Seizures are a common initial symptom of malignant brain tumors such as glioblastoma (GBM). However, why some of these tumors are epileptogenic and others never trigger seizures remains controversial.

Objective: To identify potential clinical and radiological features of epileptogenic tumors and the effect of initial seizures on survival. Read More

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http://dx.doi.org/10.1093/neuros/nyz079DOI Listing
March 2019
4 Reads

Interventional Photothermal Therapy Enhanced Brachytherapy: A New Strategy to Fight Deep Pancreatic Cancer.

Adv Sci (Weinh) 2019 Mar 15;6(5):1801507. Epub 2019 Jan 15.

Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China.

Photothermal-radiotherapy (PT-RT) is an effective strategy for relieving hypoxia-related radiotherapy resistance and inducing tumor-specific cell apoptosis/necrosis. Nevertheless, limited tissue penetration of near-infrared (NIR) laser and the serious side effects of high-dose radiation severely hinder its applications for deep tumors. An interventional photothermal-brachytherapy (IPT-BT) technology is proposed here for the internal site-specific treatment of deep tumors. Read More

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http://dx.doi.org/10.1002/advs.201801507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402393PMC

Intraoperative Molecular Imaging with Second Window Indocyanine Green Facilitates Confirmation of Contrast-Enhancing Tissue During Intracranial Stereotactic Needle Biopsy: A Case Series.

World Neurosurg 2019 Mar 15. Epub 2019 Mar 15.

Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Background: Stereotactic needle biopsy provides a minimally invasive option for the diagnosis of intracranial lesions but is limited by inconclusive diagnoses on frozen pathology. For rapid pathology, 5-aminovelunic acid and sodium fluorescein have previously demonstrated potential as diagnostic adjuvants. Stereotactic biopsy with near-infrared (NIR) fluorophores has not been reported. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.231DOI Listing
March 2019
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Early Closure of a Phase 1 Clinical Trial for SABR in Early-Stage Glottic Cancer.

Int J Radiat Oncol Biol Phys 2019 Mar 14. Epub 2019 Mar 14.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institution, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. Electronic address:

Purpose: The early results of a phase 1 study of stereotactic ablative radiation therapy for early-stage glottis cancer were previously reported. However, additional late adverse events occurred in the second arm during the follow-up period. In this study, the dose-limiting toxicities and premature closure of the clinical trial are reported. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.011DOI Listing
March 2019
2 Reads
4.258 Impact Factor

Phase 1 Fractional Dose-Escalation Study of Equipotent Stereotactic Radiation Therapy Regimens for Early-Stage Glottic Larynx Cancer.

Int J Radiat Oncol Biol Phys 2019 Mar 14. Epub 2019 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Purpose: Early-stage glottic larynx squamous cell carcinoma (GLC) is a relatively common disease with excellent oncologic control, but treatment is associated with acute dysphagia and long-term voice quality changes. This phase 1 study of hypofractionated radiation therapy for early-stage GLC increased the fraction size while reducing the number of fractions until 5-fraction stereotactic ablative radiation therapy (SABR) was delivered.

Methods And Materials: Eligible patients had received a diagnosis of stage Tis to T2 GLC. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.010DOI Listing
March 2019
6 Reads

MRI evaluation of pulmonary lesions and lung tissue changes induced by tuberculosis.

Int J Infect Dis 2019 Mar 12;82:138-146. Epub 2019 Mar 12.

Department of Radiology, The People's Hospital of Longhua, Shenzhen, Southern Medical University, Guangdong, China; Graduate School, Medical College of Nanchang University, Nanchang, Jiangxi, China; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:

Objective: To evaluate the utility of magnetic resonance imaging (MRI) with an advanced motion correction technique in characterizing lung tissue changes and lesions induced by pulmonary tuberculosis (TB).

Methods: Sixty-three subjects with computed tomography (CT) features of pulmonary TB underwent lung MRI. All subjects with pulmonary TB were confirmed by acid-fast bacillus (AFB) testing or the detection of Mycobacterium tuberculosis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.03.004DOI Listing
March 2019
4 Reads
2.330 Impact Factor

Development and validation of a model for temporal lobe necrosis for nasopharyngeal carcinoma patients with intensity modulated radiation therapy.

Radiat Oncol 2019 Mar 12;14(1):42. Epub 2019 Mar 12.

Department of radiation oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: To develop and validate a quantitative complication model of temporal lobe necrosis (TLN). To analyze the effect of clinical and dosimetric factors on TLN.

Patients And Methods: In this study the prediction model was developed in a training cohort that consisted of 256 nasopharyngeal carcinoma (NPC) patients from January 2009 to December 2009. Read More

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http://dx.doi.org/10.1186/s13014-019-1250-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416868PMC
March 2019
1 Read

Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes.

Int J Nanomedicine 2019 21;14:1385-1400. Epub 2019 Feb 21.

Klebs Research Center, Department of Dermatology, Yanbian University Hospital, Yanji 133000, China,

Background: Keloids represent benign fibroproliferative tumors which result from elevated expression of inflammation. Paclitaxel (PTX) was an effective chemotherapeutic agent and has been reported to have anti-fibrotic effects, but the strong hydrophobicity brings a challenge for its clinical application.

Purpose: The objective of this study was to improve the water solubility of PTX and investigate its anti-keloid effects. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390862PMC
http://dx.doi.org/10.2147/IJN.S195375DOI Listing
April 2019
4 Reads

Computed tomography scan imaging in diagnosing acute uncomplicated pancreatitis: Usefulness cost.

World J Gastroenterol 2019 Mar;25(9):1080-1087

Department of Gastroenterology, Advocate Christ Medical Center, Oak Lawn, IL 60453, United States.

Background: Literature has suggested that imaging is over-utilized in the diagnosis of pancreatitis. If the diagnosis of acute pancreatitis (AP) is established with abdominal pain and increased serum amylase or lipase activity without systemic signs of severe disease, computed tomography (CT) imaging may not be necessary. We hypothesize that among patients with uncomplicated acute pancreatitis (AUP), there is a significant number of unwarranted CT imaging studies. Read More

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http://dx.doi.org/10.3748/wjg.v25.i9.1080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406186PMC
March 2019
2 Reads

Salvage Carbon-Ion Radiation Therapy For Locoregionally Recurrent Head and Neck Malignancies.

Sci Rep 2019 Mar 12;9(1):4259. Epub 2019 Mar 12.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.

To investigate the safety and efficacy of salvage carbon-ion radiation therapy (CIRT) in patients with locoregionally recurrent head and neck malignancies. One hundred and forty-one patients with locally recurrent head and neck malignancies previously treated with radiotherapy were salvaged using intensity-modulated carbon-ion radiation therapy (CIRT). The median dose was 60 Gray-Equivalent (GyE) (range 50-69 GyE, 2. Read More

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http://dx.doi.org/10.1038/s41598-019-39241-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414648PMC
March 2019
5.078 Impact Factor

Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Down Regulation and Recruitment of Bone Marrow Cells.

Stem Cells 2019 Mar 12. Epub 2019 Mar 12.

Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Radiation therapy to anatomic regions including the head and neck, chest wall, and extremities can produce radiation-induced fibrosis (RIF). To elucidate the cellular and molecular mechanism(s) involved in RIF, female C57BL/6J mice were irradiated to the right flank to 35 Gy in single fraction using 6 Mv electrons. Radiation fibrosis was detected by day 14, was increased by day 28, and confirmed by Masson's trichrome histological staining for collagen. Read More

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http://dx.doi.org/10.1002/stem.3000DOI Listing