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Oncol Lett 2022 Jul 31;24(1):239. Epub 2022 May 31.

Department of Gynecological Oncology, Shandong University Cancer Center, Jinan, Shandong 250117, P.R. China.

Concurrent chemoradiation therapy (CCRT) is the standard treatment for locally advanced cervical cancer. The present study aimed to compare the therapeutic responses, toxicities and dosimetric parameters between intensity-modulated radiation therapy (IMRT) and tomotherapy (TOMO) in patients with advanced cervical cancer. This retrospective study included 310 patients with stage IIB-IIIB cervical cancer who underwent CCRT, with 155 patients in each group. Read More

Clin Oncol (R Coll Radiol) 2022 Jun 14. Epub 2022 Jun 14.

Division of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland; Faculty of Medicine, Geneva University, Geneva, Switzerland. Electronic address:

Aims: Although the results on acute and late toxicity of ultrahypofractionation are encouraging, data on safety in prostate cancer patients with a medical history of transurethral resection of the prostate (TURP) or adenomectomy remain scarce, especially in cases of repeated procedures. The aim of the present study was to report on long-term toxicities after stereotactic body radiotherapy (SBRT) of prostate cancer patients with previous surgical treatment of benign prostatic hyperplasia.

Materials And Methods: Among 150 patients treated with SBRT (median dose 36. Read More

Undersea Hyperb Med 2022 Second Quarter;49(2):191-195

UCLA Hyperbaric Medicine, Los Angeles, California U.S.

Hyperbaric oxygen (HBO2) therapy is a UHMS-approved treatment for radiation cystitis and has been used for other causes of cystitis such as cyclophosphamide-induced hemorrhagic cystitis and interstitial cystitis, among others. Immunotherapy with Bacillus Calmette-Guérin (BCG) is the most effective treatment of non-muscle invasive bladder cancer. BCG acts as a non-specific stimulant of the reticuloendothelial system, causing a local inflammatory response. Read More

Urol Oncol 2022 07 8;40(7):344.e19-344.e25. Epub 2022 Apr 8.

Department of Urology, Fundació Puigvert, Autonomous University of Barcelona, Barcelona, Spain.

Introduction & Objectives: Radiation-induced haemorrhagic cystitis (RHC) is a frightening complication occurring after pelvic radiotherapy (PRT) which may significantly affect patients' quality of life. Bladder instillation with glycosaminoglycan replacement therapy (GRT) including hyaluronic acid +/- chondroitin sulphate has been proposed as an emerging alternative to prevent relapses of haematuria. Strong points in favour of using GRT for RHC are the ease of administration, cost, almost absence of side effects and possibility of administration to outpatients. Read More

Diving Hyperb Med 2022 Mar;52(1):27-34

Istanbul University, Istanbul Faculty of Medicine, Underwater and Hyperbaric Medicine Department, Istanbul, Turkey.

Introduction: Intractable haemorrhagic cystitis (HC) is a serious complication of chemotherapy (CT) and haematopoietic stem cell transplantation (HSCT). Hyperbaric oxygen treatment (HBOT) is a promising treatment option based on the similarities in injury pattern and observed histological changes with radiation induced HC, which is an approved indication. We present our experience with HBOT in HC occurring after CT and HSCT. Read More

Acta Biomater 2022 05 14;144:221-229. Epub 2022 Mar 14.

Department of Mechanical Engineering, Michigan State University, East Lansing, MI, United States. Electronic address:

Radiation cystitis, a long-term bladder defect due to pelvic radiation therapy, results in lower urinary tract symptoms, such as urinary frequency and nocturia, suggestive of compromised bladder compliance. The goal of this study was to identify alterations to the mechanical behavior of the urinary bladder extracellular matrix of a murine model of radiation cystitis, at 3 and 6 months after radiation exposure. The results of this study demonstrated that the extracellular matrix of irradiated bladders was significantly less distensible when compared to age matching controls. Read More

Urol Int 2022 Mar 15:1-7. Epub 2022 Mar 15.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Objectives: This study aimed to evaluate the cumulative incidence of overall and severe radiation cystitis following external beam radiation therapy for prostate cancer and investigate the clinical factors predictive of radiation cystitis.

Methods: This retrospective study comprised 246 patients who received external beam radiation therapy for localized or locally advanced prostate cancer between 2013 and 2016 in our institution. Of these, 189 received primary radiation therapy and 57 received adjuvant/salvage radiation therapy. Read More

Sci Rep 2022 03 14;12(1):4371. Epub 2022 Mar 14.

Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Office 1R203, Miami, FL, 33176, USA.

Hospitalizations due to radiotherapy (RT) complications result in significant healthcare expenditures and adversely affect the quality of life of cancer patients. Using a nationally representative dataset, the objective of this study is to identify trends in the incidence of these hospitalizations, their causes, and the resulting financial burden. Data from the National Inpatient Sample was retrospectively analyzed from 2005 to 2016. Read More

Front Oncol 2022 22;12:814414. Epub 2022 Feb 22.

Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To investigate the appropriate rectal volume for external irradiation of cervical cancer.

Methods: A retrospective study of 143 patients with cervical cancer who underwent external radiotherapy from January 2017 to September 2020 was conducted. Average rectum volumes and the cumulative dose (V30, V40, V50, D2cc) to organs at risk (bladder, rectum, and small bowel) during radiotherapy were evaluated using the treatment planning system. Read More

Front Surg 2022 31;9:838848. Epub 2022 Jan 31.

Department of Nephrology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Purpose: Discuss the implementation effect of cervical cancer comprehensive treatment patients applying whole-course high-quality care combined with network continuation care.

Methods: From August 2020 to August 2021, 120 patients who met the inclusion criteria for comprehensive treatment of cervical cancer were divided into the regular group ( = 60) who received conventional care and the joint group ( = 60) who received whole-course high-quality care combined with network continuation care, according to the method of care. The comprehensive treatment cognition level, comprehensive treatment compliance, adverse reaction rate, quality of life questionnaire (QLQ-C30) score, self-rating anxiety/depression scale (SAS/SDS) score, and nursing satisfaction were compared between the two groups. Read More

Int J Mol Sci 2022 Feb 6;23(3). Epub 2022 Feb 6.

Service de Recherche en Radiobiologie et en Médecine Régénérative (SERAMED), Laboratoire de Radiobiologie des Expositions Médicales (LRMED), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), 31 Avenue de la Division Leclerc, Fontenay-aux-Roses, 92260 Paris, France.

Chronic radiation cystitis (CRC) is a consequence of pelvic radiotherapy and affects 5-10% of patients. The pathology of CRC is without curative treatment and is characterized by incontinence, pelvic pain and hematuria, which severely degrades patients' quality of life. Current management strategies rely primarily on symptomatic measures and have certain limitations. Read More

Prog Urol 2022 Apr 4;32(5):388-399. Epub 2022 Feb 4.

Service d'urologie, université de Rouen, hôpital Charles-Nicolle, 76000 Rouen, France.

Introduction: Inflammatory and sensory chronic bladder diseases have a significant impact on quality of life. These pathologies share alteration of the layer between urine and urothelium, making the use of topical agents appropriate.

Objectives: Review the efficacy and tolerance of intravesical treatments for these pathologies. Read More

Transl Cancer Res 2021 Feb;10(2):1096-1118

Department of Urology and Oncologic Urology, Wroclaw Medical University, Wrocław, Poland.

Radiation therapy along with chemotherapy and surgery are the three main treatment modalities used in oncology. The main disadvantage of radiotherapy is the fact that it affects both cancer and healthy cells located in the tumour area. As a consequence, different complications develop. Read More

J Contemp Brachytherapy 2021 Dec 30;13(6):649-654. Epub 2021 Dec 30.

Department of Radiation Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.

Purpose: Treatment of isolated post-surgical vault recurrence of cervical and endometrial cancers in previously unirradiated patients includes external beam radiotherapy (EBRT) ± concomitant chemotherapy, followed by brachytherapy (BT) boost. Supra-vaginal component of vault disease often requires interstitial BT for optimal dose coverage. We describe technical details and preliminary case series using modified Houdek vault applicator (MHVA) developed at our institution for limited intra-cavitary plus interstitial high-dose-rate (HDR) vault BT. Read More

Rep Pract Oncol Radiother 2021 30;26(6):948-954. Epub 2021 Dec 30.

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.

Background: Addition of chemotherapy to radiation has improved 5-year survival by 6%. However, the optimal dose and schedule of concurrent cisplatin is not well defined, though widely accepted practice is the weekly schedule of 40 mg/m for 5 weeks. Repeated admissions for weekly cisplatin drain the limited resources in high volume centres. Read More

Arch Ital Urol Androl 2021 Sep 30;93(3):255-261. Epub 2021 Sep 30.

Division of Urology, Department of Clinical, Special and Dental Sciences, University Hospital "Ospedali Riuniti" School of Medicine, Marche Polytechnic University, Ancona.

Objective: To review the literature on the impact on female quality of life and sexual function of orthotopic reconstruction after radical cystectomy for non-malignant bladder conditions. Radical cystectomy is commonly required to treat malignant conditions but may also be considered for the treatment of non-malignant diseases. These heterogeneous group of disorders includes interstitial cystitis, painful bladder syndrome, neurogenic bladder, haemorrhagic/ radiation cystitis, endometriosis and refractory genitourinary fistula. Read More

BJU Int 2021 Nov 22. Epub 2021 Nov 22.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA.

Objectives: To elucidate the national burden of emergency department (ED) visits for radiation cystitis (RC), a known complication of radiation therapy (RT) to the pelvic area, among patients with a prostate cancer history, and identify those who are at increased risk of requiring invasive measures.

Patients And Methods: This study queried the Nationwide Emergency Department Sample for all ED visits from January 2006 to December 2015 with a primary diagnosis of RC and secondary diagnosis of prostate cancer. ED visits were characterised by demographic factors, socioeconomic factors, and hospital characteristics. Read More

Transl Androl Urol 2021 Oct;10(10):3899-3906

Department of Radiology, Nihon University School of Medicine, Itabashi, Tokyo, Japan.

The pathogenesis of bladder marginal zone/mucosa-associated lymphoid tissue (MALT) lymphoma, which is the most common type of primary bladder lymphoma, has not been clarified. There are no reports that described histological and molecular time course of MALT lymphoma occurring in the bladder and the importance of the score on the Pelvic Pain and Urgency/Frequency (PUF) patient symptom scale during and after radiation therapy (RT). We present a case of MALT lymphoma with long-term comparative genetic analysis. Read More

Cancer Manag Res 2021 3;13:8307-8316. Epub 2021 Nov 3.

Department of Oncology, The Affiliated Hospital of Guizhou Medical University, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, 550004, People's Republic of China.

Purpose: To examine the clinical significance of unoperated cervical cancer patients treated with different neoadjuvant chemotherapy (NACT) schemes followed by concurrent chemotherapy and radiotherapy (CCRT).

Methods: This retrospective analysis included women with locally advanced cervical cancer treated with NACT-CCRT between September 2011 and September 2014. Neoadjuvant chemotherapy included paclitaxel plus cisplatin (TP group; 62 patients) or paclitaxel plus loplatin (TL group; 58 patients), which were administered three weekly, and cisplatin or loplatin, which were administered weekly for synchronous chemotherapy. Read More

Minerva Urol Nephrol 2022 Jun 29;74(3):281-291. Epub 2021 Oct 29.

Department of Urology, Campus Bio-Medico University, Rome, Italy.

Introduction: We aimed to summarize current literature about radiation cystitis treatments, providing physician of a summary of current management options.

Evidence Acquisition: A systematic literature review searching on PubMed (Medline), Scopus, and Web of Science databases was performed in March 2021. PRISMA guidelines were followed. Read More

Angew Chem Int Ed Engl 2021 12 8;60(50):26337-26341. Epub 2021 Nov 8.

Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University, Shanghai, 200433, China.

Inflammation usually results in high-level reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only in acidic tissue but also in alkaline tissue. However, noninvasively in vivo monitoring reactive species specifically within alkaline tissue remains a huge challenge. Here we introduce a dual activatable fluorescent probe PN910 located in the second near-infrared window (NIR-II, 900-1700 nm), which shows high selectivity toward H O and OONO at pH beyond 7. Read More

Case Rep Urol 2021 23;2021:2060572. Epub 2021 Sep 23.

Department of Urology, Yale University School of Medicine, New Haven, CT, USA.

Background: Intraoperative imaging for endourologic procedures is generally limited to single-plane fluoroscopic X-ray. The O-arm™ is a mobile cone-bean CT scanner that may have applications in urologic surgeries. . Read More

Sci Rep 2021 09 29;11(1):19277. Epub 2021 Sep 29.

Beaumont Health System, Medical Office Building, 3535 W. 13 Mile Road, Suite 438, Royal Oak, MI, 48073, USA.

Long term-side effects from cancer therapies are a growing health care concern as life expectancy among cancer survivors increases. Damage to the bladder is common in patients treated with radiation therapy for pelvic cancers and can result in radiation (hemorrhagic) cystitis (RC). The disease progression of RC consists of an acute and chronic phase, separated by a symptom-free period. Read More

Diagnostics (Basel) 2021 Sep 4;11(9). Epub 2021 Sep 4.

Department of Oncology, Radiation Therapy and Radiological Diagnostics, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Sq., 603950 Nizhny Novgorod, Russia.

Radiation therapy is one of the cardinal approaches in the treatment of malignant tumors of the pelvis. It leads to the development of radiation-induced complications in the normal tissues. Thus, the evaluation of radiation-induced changes in the extracellular matrix of the normal tissue is deemed urgent, since connective tissue stroma degradation plays a crucial role in the development of Grade 3-4 adverse effects (hemorrhage, necrosis, and fistula). Read More

J BUON 2021 Jul-Aug;26(4):1298-1305

Department of Obstetrics and Gynecology, Lishui City People's Hospital, Lishui, China.

Purpose: We aimed to evaluate the efficacy and safety of helical tomotherapy (HT) combined with computed tomography (CT)-guided three-dimensional intracavitary brachytherapy (CT-ICBT) in the treatment of locally advanced cervical cancer.

Methods: A total of 96 patients with locally advanced cervical cancer (IIB-IIIB) treated were retrospectively analyzed. They underwent concurrent radiochemotherapy, and the chemotherapy regimen paclitaxel + cisplatin was given for 3 weeks. Read More

World J Urol 2022 Jan 22;40(1):141-146. Epub 2021 Sep 22.

Department of Urology, NHC, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Purpose: To assess the efficacy and safety of intravesical instillation of high molecular weight sodium hyaluronate (HMW-HA) for the treatment of radiation-induced cystitis.

Methods: This prospective cohort study was conducted in seven centers in France. Eligible patients with radiation-induced cystitis were recruited between April 2020 and March 2021. Read More

Case Rep Obstet Gynecol 2021 9;2021:1737975. Epub 2021 Sep 9.

Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara Okinawa 903-0215, Japan.

Patients with gynecological malignancies can develop radiation injuries, such as cystitis, proctitis, and soft tissue necrosis which have approved indications for hyperbaric oxygen therapy (HBOT). A 76-year-old Japanese woman with vaginal recurrence of cervical cancer was treated with the high-dose rate interstitial brachytherapy. Twenty-one months after the irradiation, she developed radiation necrosis on the external urethral opening. Read More

J Cancer Res Ther 2021 Jul-Sep;17(4):975-981

Department of Radiation Oncology, Tata Medical Center, Kolkata, West Bengal, India.

Objective: Concurrent chemoradiotherapy (CCRT) is the standard curative treatment option for nonmetastatic anal squamous cell carcinoma (SCC). Intensity modulated radiotherapy (IMRT) can reduce doses delivered to bowel and skin and reduce toxicities associated with conventional fields. Here, we present our institutional data on dosimetry, toxicity, and clinical outcomes with IMRT for anal cancer. Read More

Cancers (Basel) 2021 Aug 27;13(17). Epub 2021 Aug 27.

Department of Radiation Oncology, Institut de Cancérologie de l'Ouest, Boulevard J. Monod, 44800 St-Herblain, France.

Prostate cancer recurrence in patients previously treated with radical prostatectomy and radiation therapy is challenging. Re-irradiation could be an option, but data regarding efficacy and safety are lacking. We retrospectively evaluated salvage re-irradiation for local recurrence after prostatectomy and external beam radiation therapy. Read More

Hinyokika Kiyo 2021 Aug;67(8):359-362

The Department of Urology, Takayama Red Cross Hospital.

We retrospectively analyzed 134 patients (male, n＝84 ; female, n＝50) with bladder tamponade at a regional hospital. The median age was 84.9 years. Read More