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Pract Radiat Oncol 2020 Jun 17. Epub 2020 Jun 17.

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, USA. Electronic address:

Purpose: To analyze dose-volume parameters associated with genitourinary (GU) toxicity from a phase I clinical trial of prostate bed stereotactic body radiotherapy (PB-SBRT).

Methods: Patients were treated in escalating dose levels of 35 Gy, 40 Gy, and 45 Gy, over 5 fractions. Data from all 26 patients enrolled on the protocol were analyzed using multiple dose-volume cutpoints for multiple GU organs at risk. Read More

Radiother Oncol 2020 May 13;149:117-123. Epub 2020 May 13.

Radiation Oncology Department, Southern Blood and Cancer Centre, Dunedin Hospital, New Zealand.

Purpose: Acute radiation cystitis affects the quality of life of many prostate cancer patients. A previous pilot study suggested that cranberry capsules may decrease some of the symptoms of acute radiation cystitis. Here we further test their effectiveness in a multicentre double blinded placebo-controlled clinical trial. Read More

J Urol 2020 May 13:101097JU000000000000110401. Epub 2020 May 13.

J Urol 2020 May 13:101097JU0000000000001104. Epub 2020 May 13.

Cancer Radiother 2020 Jul 28;24(4):345-353. Epub 2020 Apr 28.

Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 5026, 63011 Clermont-Ferrand cedex 1, France. Electronic address:

Preoperative radiotherapy boosted by chemotherapy is a recommended treatment in locally advanced rectal cancers. This treatment is delivered by three dimensional conformal irradiation, which is usually well tolerated but can induce potential toxicity such as rectitis, cystitis and hematologic adverse effects. Intensity-modulated radiotherapy, widely available nowadays, allows optimization of volume covering and sparing of organs at risk such as bladder and bone marrow. Read More

J Gynecol Oncol 2020 May;31(3):e48

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

In 2019, 12 topics were selected as the major research advances in gynecologic oncology. Herein, we first opted to introduce the significant clinical activity of pembrolizumab in women with advanced cervical cancer based on the results of the phase 2 KEYNOTE-158 trial. Thereafter, we reviewed 5 topics, including systemic lymphadenectomy in the advanced stage with no gross residual tumor, secondary cytoreductive surgery in recurrent ovarian cancer according to the results of Gynecologic Oncology Group-213 trial, dose-dense weekly paclitaxel scheduling as first-line chemotherapy, the utility of intraperitoneal therapy in the advanced stage, and an update on poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. Read More

Urol Case Rep 2020 Jul 3;31:101169. Epub 2020 Apr 3.

Medical College of Georgia, USA.

There are three major recognized histological types for primary urethral carcinoma (PUC). These include transitional cell carcinoma (55%), squamous cell carcinoma (21.5%), and adenocarcinoma (16. Read More

Lasers Med Sci 2020 Apr 18. Epub 2020 Apr 18.

Department of Urology, The Second People's Hospital of Lianyungang, 161 Xingfu Road, Lianyungang, 222023, Jiangsu, China.

The purpose of this study was to evaluate the efficacy of a 980-nm diode laser coagulation in women with radiation-induced hemorrhagic cystitis (RHC). We conducted a retrospective study of 21 RHC patients treated with a 980-nm diode laser between July 2014 and December 2017 at our institution. Data was collected with regard to age, sex, lower urinary tract symptoms, use of transfusions, a drop in hemoglobin levels, indication of radiotherapy, median time between radiation therapy and presentation, previous treatments, operative time, mean energy used, number of coagulated areas, catheterization time, discharge time after treatment, hospital stay, and surgical outcome. Read More

Am J Transl Res 2020 15;12(3):999-1015. Epub 2020 Mar 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Taiwan.

Background: This study tested the long-term effect of extracorporeal shock wave (ECSW) therapy on ameliorating radiotherapy-induced chronic cystitis (CC) in rat.

Methods And Results: Adult-female SD rats (n = 24) were equally categorized into group 1 (normal control), group 2 (CC induced by radiotherapy with 450 cGy twice with a four-hour interval to the urinary bladder), group 3 [CC with ECSW treatment (0.1 mJ/mm/120 impulses once every 3 days after radiotherapy)]. Read More

Urology 2020 Jun 16;140:64-69. Epub 2020 Mar 16.

Department of Urology, Royal Newcastle Centre, Australia.

Objectives: To describe patients presenting with urologic complications following pelvic radiation therapy and estimate the financial costs incurred in their treatment.

Patients And Methods: In the year ending June 2018, all urology admissions at Royal Newcastle Centre were reviewed for diagnostic codes pertaining to urethral or ureteric strictures, cystitis, and haematuria. Presentations were complications following radiotherapy if a diagnosis of radiation cystitis or stricture was recorded, and there was relevant prior radiotherapy. Read More

Int Immunopharmacol 2020 Jun 14;83:106334. Epub 2020 Mar 14.

Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Department of Oncology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

In the present study we assessed how ionizing radiation affects TLR4-stimulated immune activation in lipopolysaccharide (LPS)-induced cystitis. LPS or saline was administered intravesically to female rats followed by urinary bladder irradiation (20 Gy) 24 h later or sham treatment. Presence in the urinary bladder of inflammatory cells (mast cells, CD3+, ionized calcium-binding adapter molecule 1 (Iba-1)+, CD68+, CD40+, CD80+, CD11c + and CD206 + cells) and expression of oxidative stress (8-OHdG), hypoxia (HIF1α) and anti-oxidative responses (NRF2, HO-1, SOD1, SOD2, catalase) were assessed 14 days later with western blot, qPCR and/or immunohistochemistry. Read More

Undersea Hyperb Med 2020 First Quarter;47(1):176

In the fourth quarter issue 2020 of the UHM Journal (46-5) we represented the NNT number (number-needed-to-treat) as “three (3)” rather than simply “3.” This appeared on Page 727 in the letter from Richard Clarke, CHT, National Baromedical Services, entitled “HBO2 for radiation cystitis.” The corrected section should have read: “Although not reported, the ‘Number Needed to Treat’ (NNT, an epidemiological measure used to communicate effectiveness of an intervention, and representing the average number of patients needed to be treated in order to produce one favorable outcome) was computed as an encouraging 3. Read More

Physiol Rep 2020 02;8(4):e14377

Department of Urology, William Beaumont Hospital, Royal Oak, MI, USA.

A subset of patients receiving radiation therapy for pelvic cancer develop radiation cystitis, a complication characterized by mucosal cell death, inflammation, hematuria, and bladder fibrosis. Radiation cystitis can reduce bladder capacity, cause incontinence, and impair voiding function so severely that patients require surgical intervention. Factors influencing onset and severity of radiation cystitis are not fully known. Read More

Int J Radiat Oncol Biol Phys 2020 Jun 5;107(2):377-385. Epub 2020 Feb 5.

ATRAB-Applied and Translational Radiobiology, Medical University of Vienna, Vienna, Austria.

Purpose: This preclinical study aimed to investigate the role of nuclear factor (NF)-κB in early and late radiogenic sequelae of urinary bladder dysfunction in mice. Thalidomide was applied either during the early or late response phase to determine potential effects of NF-κB inhibition on functional bladder impairment.

Methods And Materials: After pelvic irradiation on day 0, female C3H/Neu mice were observed over a period of 360 days and radiation response was evaluated for alterations in bladder functionality and NF-κB activation. Read More

Xenotransplantation 2020 Jan 13:e12578. Epub 2020 Jan 13.

Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon.

Allogeneic hematopoietic stem cell transplantation (HSCT) and xenotransplantation are accompanied by viral reactivations and virus-associated complications resulting from immune deficiency. Here, in a Mauritian cynomolgus macaque model of fully MHC-matched allogeneic HSCT, we report reactivations of cynomolgus polyomavirus, lymphocryptovirus, and cytomegalovirus, macaque viruses analogous to HSCT-associated human counterparts BK virus, Epstein-Barr virus, and human cytomegalovirus. Viral replication in recipient macaques resulted in characteristic disease manifestations observed in HSCT patients, such as polyomavirus-associated hemorrhagic cystitis and tubulointerstitial nephritis or lymphocryptovirus-associated post-transplant lymphoproliferative disorder. Read More

Urol Video J 2019 Dec 22;4. Epub 2019 Nov 22.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

Introduction And Objective: Robot-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) has become an increasingly utilized approach to treating various bladder pathologies requiring extirpation. As surgeons have become more experienced with ICUD, especially with lesser-used diversions such as continent cutaneous reservoirs, the technique has evolved.

Methods: We describe our technique and recent advances in the practical creation of robotic ICUD with a continent catheterizable pouch (CCP) built upon the open principles of the previously described "Indiana Pouch, " which uses the distal ileum and right colon. Read More

Int Braz J Urol 2020 Jan-Feb;46(1):108-115

Department of Urology, Boston Medical Center/Boston University School of Medicine Boston.

Objective: Cystectomy with urinary diversion is the gold standard for muscle invasive bladder cancer. It also may be performed as part of pelvic exenteration for non-urologic malignancy, neurogenic bladder dysfunction, and chronic conditions that result in a non-functional bladder (e.g. Read More

Indian J Pediatr 2019 Dec 11. Epub 2019 Dec 11.

Department of Pediatrics, All India Institiute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Urinary tract infection (UTI) is defined as the growth of a significant number of microorganisms of a single species in the urine, in the presence of symptoms. Symptoms in young children are non-specific such as fever without focus; young infants may manifest with irritability, failure to thrive, jaundice, vomiting and diarrhea. Older children usually have symptoms of cystitis or pyelonephritis. Read More

Lancet Oncol 2019 12;20(12):e660

National Baromedical Services, Columbia, SC 29203, USA. Electronic address:

Clinics (Sao Paulo) 2019 25;74:e1388. Epub 2019 Nov 25.

Departamento de Radiologia e Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: The purpose of this study was to evaluate the incidence of urinary tract infection (UTI) in patients with cystitis symptoms who underwent pelvic radiation therapy and identify correlated predictive factors.

Methods: A prospective cohort study was conducted of patients who met the following: primary pelvic cancer treated with curative intent, older than 18 years old, and good performance status. The exclusion criteria were patients being treated for a UTI, using a urinary catheter, in dialysis or with cystostomy or nephrostomy, and using antibiotics during treatment. Read More

Undersea Hyperb Med 2019 ;46(5):725-727

National Baromedical Services, Columbia, South Carolina, U.S.

Int J Radiat Oncol Biol Phys 2020 02 1;106(2):310-319. Epub 2019 Nov 1.

Department of Radiation Oncology, Tata Memorial Hospital, Tata Memorial Centre, Parel, Mumbai, India.

Purpose: This phase II study evaluated the utility of magnetic resonance imaging (MRI) and positron emission tomography for planning radiation and brachytherapy in patients with postsurgical recurrence of cervical cancer.

Methods And Materials: The study (NCT01391065) recruited patients with residual or recurrent disease after hysterectomy. Patients underwent baseline T2 weighted (T2W) MRI, F-flouro-deoxyglucose (F-FDG), F-flouro thymidine (F-FLT) and F-flouromisonidazole (F-F Miso) positron emission tomography (PET) and received external radiation (50 Gy/25 fractions for 5 weeks) and weekly cisplatin (40 mg/m). Read More

Turk J Med Sci 2019 Oct 24;49(5):1484-1489. Epub 2019 Oct 24.

Department of Radiation Oncology, Academician F. Todua Medical Center-Research Institute of Clinical Medicine, Tbilisi, Georgia

Background/aim: The present study aimed to examine whether the combination of neoadjuvant volumetric modulated arc radiotherapy (VMAT) using simultaneous integrated boost (SIB-VMAT) techniques and chemotherapy with capecitabine is associated with better clinical and dosimetric outcomes compared to the standard treatment.

Materials And Methods: The study included 59 patients with cT2–T4 rectal cancer. In the standard arm, patients (n = 37) were treated preoperatively with image-guided VMAT plus capecitabine. Read More

Int J Urol 2020 Feb 15;27(2):98-107. Epub 2019 Oct 15.

Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

The present study assessed the efficacy of hyperbaric oxygen therapy in reducing symptoms of radiation cystitis, a specific type of iatrogenic injury to the bladder, by systematic review of recent literature. The MEDLINE, Embase and Web of Science databases were searched using combinations of the terms "radiation," "cystitis" and "hyperbaric oxygen" to identify articles evaluating patients with radiation cystitis, treated with hyperbaric oxygen therapy. Only recent (≤10 years) original studies were included. Read More

Radiol Med 2020 Jan 24;125(1):87-97. Epub 2019 Sep 24.

Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Purpose: Radiomic features, clinical and dosimetric factors have the potential to predict radiation-induced toxicity. The aim of this study was to develop prediction models of radiotherapy-induced toxicities in prostate cancer patients based on computed tomography (CT) radiomics, clinical and dosimetric parameters.

Methods: In this prospective study, prostate cancer patients were included, and radiotherapy-induced urinary and gastrointestinal (GI) toxicities were assessed by Common Terminology Criteria for adverse events. Read More

Lancet Oncol 2019 11 16;20(11):1481-1482. Epub 2019 Sep 16.

University of Toledo Medical Center, Radiation Oncology, Toledo, 43614 OH, USA. Electronic address:

Lancet Oncol 2019 11 16;20(11):1602-1614. Epub 2019 Sep 16.

Department of Anaesthesiology and Intensive Care, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Background: Late radiation cystitis is an adverse effect of cancer treatment with radiotherapy in the pelvic region. Symptoms of late radiation cystitis can be assessed with the Expanded Prostate Index Composite Score (EPIC). Previous reports indicate that hyperbaric oxygen therapy reduces symptoms from late radiation cystitis, but the evidence is predominantly based on non-randomised and retrospective studies. Read More

Front Oncol 2019 16;9:760. Epub 2019 Aug 16.

State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

To evaluate treatment outcomes and toxicity in patients with cervical cancer (CC) treated with volumetric modulated arc therapy (VMAT), followed by three-dimensional high-dose-rate intracavity combined with interstitial brachytherapy (IC/IS BT) compared with intensity-modulated radiation therapy (IMRT) treatment. A total of 398 patients with stage IA-IVB CC treated with definitive radiotherapy with or without chemotherapy were retrospectively analyzed (331 VMAT and 67 IMRT). A total prescription dose of 45-50 Gy was delivered to pelvic field with VMAT/IMRT in 25/28 fractions, with five fractions per week. Read More

Climacteric 2020 Feb 2;23(1):53-58. Epub 2019 Sep 2.

1st Department of Obstetrics and Gynecology, 'Alexandra' Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Sexual dysfunction and radiation cystitis are common adverse events following radiotherapy for gynecological cancer (GC). This study aims to assess the efficacy of intravaginal CO laser on GC survivors with dyspareunia following pelvic radiation and/or brachytherapy. This is the study protocol of a randomized double-blind placebo-controlled trial. Read More

Cancer Manag Res 2019 29;11:7171-7181. Epub 2019 Jul 29.

Department of Radiotherapy, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.

Objective: This study aimed to investigate the impact of bladder volume on treatment planning and clinical outcomes of radiotherapy for patients with cervical cancer.

Materials And Methods: One hundred and sixty-six patients with locally advanced cervical cancer were selected in this retrospective study. The patients were divided into four groups according to their average bladder volume during radiotherapy (external beam radiation therapy and intracavitary brachytherapy): group A: V<100 mL, group B: 100 mL≤V≤150 mL, group C: 150 mL200 mL. Read More

Int J Radiat Oncol Biol Phys 2019 12 13;105(5):1086-1094. Epub 2019 Aug 13.

Department of Radiation Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Purpose: Use of stereotactic body radiation therapy (SBRT) is increasing in patients with localized prostate cancer, but concerns about early and late gastrointestinal (GI) and genitourinary (GU) toxicity exist after moderately or extremely hypofractionated radiation therapy schemes. Magnetic resonance guided radiation therapy (MRgRT) was clinically introduced in 2014. MrgRT allows for SBRT delivery with smaller uncertainty margins and permits daily adaptive planning. Read More

Indian J Palliat Care 2019 Jul-Sep;25(3):471-473

Department of Obstetrics and Gynaecology, JSS Medical College and Hospital, Mysore, Karnataka, India.

Radiation-induced hemorrhagic cystitis (HC) is an unpleasant and sometimes life-threatening complication confronted while treating pelvic malignancies. A wide array of treatment modalities such as bladder irrigation, fulguration, hyperbaric oxygen therapy, and surgical methods has been proposed to treat hematuria, but there is no consensus on the optimal therapeutic strategy for the same. Reported here is a successful superselective embolization of the bilateral vesical arteries in a patient with refractory radiation-induced HC. Read More

Int J Crit Illn Inj Sci 2019 Apr-Jun;9(2):101-104

Department of Gastroenterology, Morehouse School of Medicine, Grady Memorial Hospital, Atlanta, Georgia, USA.

Bladder necrosis and perforation is a rare and life-threatening medical emergency. Risk factors include trauma, malignancy, previous surgery and/or radiation therapy and diabetes mellitus. Signs, symptoms, and imaging findings are often obscure making the diagnosis difficult. Read More

Neurourol Urodyn 2019 09 14;38(7):1966-1972. Epub 2019 Jul 14.

Samuel Oschin Comprehensive Cancer Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.

Aims: The complexity of Interstitial Cystitis/bladder Pain Syndrome (IC/BPS) has led to a great deal of uncertainty around the diagnosis and prevalence of the condition. Under the hypothesis that IC/BPS is frequently misdiagnosed, we sought to assess the accuracy of the ICD-9/ICD-10 code for IC/BPS using a national data set.

Methods: Using the Veterans Affairs Informatics and Computing Infrastructure, we identified a random sample of 100 patients with an ICD-9/ICD-10 diagnosis of IC/BPS (595. Read More

Urology 2019 Sep 12;131:190-195. Epub 2019 Jun 12.

Detroit Medical Center, Department of Urology, Detroit, MI.

Objective: To determine if reported incidence rates of hemorrhagic cystitis after radiation therapy for prostate cancer are accurate, to investigate the effect of different radiation modalities on the development of hemorrhagic cystitis and to assess its morbidity and treatment.

Materials And Methods: A retrospective chart review was completed of 709 patients at 2 Detroit Medical Center hospitals who underwent radiation therapy for prostate cancer between January 2000 and September 2015. In patients who developed hemorrhagic cystitis, we analyzed the incidence, radiation modality, morbidity, treatment, and complications. Read More

Biol Blood Marrow Transplant 2019 10 11;25(10):2017-2023. Epub 2019 Jun 11.

Medical Faculty Pediatric Hematology and Oncology Department, Akdeniz University, Antalya, Turkey. Electronic address:

Hematopoietic stem cell transplantation (HSCT) is the only curative treatment for bone marrow failure (BMF) in patients with Fanconi anemia (FA). We retrospectively analyzed the records of patients with FA who underwent HSCT with a radiation-free, reduced-intensity conditioning regimen (fludarabine, cyclophosphamide, and antithymocyte globulin) along with an unmanipulated graft infusion between 2004 and 2018. A total of 44 patients underwent HSCT during the study period. Read More

J Med Imaging Radiat Sci 2019 06 18;50(2):252-260. Epub 2019 Jan 18.

Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The main purpose of this study was to assess the structural changes in the bladder wall of prostate cancer patients treated with intensity-modulated radiation therapy using magnetic resonance imaging texture features analysis and to correlate image texture changes with radiation dose and urinary toxicity.

Methods: Ethical clearance was granted to enroll 33 patients into this study who were treated with intensity-modulated radiation therapy for prostate cancer. All patients underwent two magnetic resonance imagings before and after radiation therapy (RT). Read More

Undersea Hyperb Med 2018 Nov-Dec;45(6):683-684

Department of Surgery, Division of Urologic Surgery, University of Nebraska Medical Center, Omaha, Nebraska U.S.

We previously published our method of performing continuous bladder irrigation (CBI) in a monoplace hyperbaric chamber [1]. This method entailed the use of an IV pump to infuse saline into the monoplace chamber. The specter of causing iatrogenic rupture of the bladder was raised following such a case, reported herein, of a woman with hemorrhagic radiation cystitis leading to cystectomy. Read More

Clin Colorectal Cancer 2019 09 6;18(3):167-174. Epub 2019 Apr 6.

Department of Radiation Oncology, University of Colorado Denver School of Medicine, Denver, CO. Electronic address:

Background: Initial treatment with either neoadjuvant chemoradiation (CRT) or induction FOLFOX (5-Fluorouracil, leucovorin, and oxaliplatin) chemotherapy followed by CRT is considered standard treatment for locally advanced rectal cancer. We compared patient-reported outcomes (PRO) during CRT in patients who had received induction chemotherapy versus those who did not.

Patients And Methods: We reviewed records of patients with locally advanced rectal cancer who were treated with CRT between September 2009 and October 2014, and who had completed ≥ 4 PRO assessments during treatment. Read More

Int J Urol 2019 09 13;26(9):860-867. Epub 2019 May 13.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan.

Hyperbaric oxygen therapy is a promising medical technology that delivers oxygen to targeted tissues at high pressure to increase the amount of dissolved oxygen in the blood. Over the past three decades, hyperbaric oxygen has been used in a variety of conditions, including radiation-induced tissue injuries, non-healing states with ischemia and malignant neoplasms. In the field of urology, hyperbaric oxygen has also been applied to some pathological conditions (e. Read More

Adv Radiat Oncol 2019 Apr-Jun;4(2):337-344. Epub 2019 Jan 31.

Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.

Purpose: This study aimed to evaluate the toxicity of prostate and pelvic lymph node stereotactic body radiation therapy (SBRT) for high-risk prostate cancer.

Methods And Materials: Twenty-three patients with high-risk or lymph node-positive prostate cancer were treated with SBRT that delivered 37.5 to 40 Gy in 5 fractions to the prostate and seminal vesicles, with concomitant treatment of the pelvic nodes to 25 Gy. Read More

J Oncol Pharm Pract 2020 Mar 22;26(2):306-311. Epub 2019 Apr 22.

Pharmacy Department, Durham Veterans Affairs Health Care System, Durham, NC, USA.

Background: Phenazopyridine is a urinary tract analgesic indicated for short-term treatment of irritation in the lower urinary tract. Despite the lack of evidence for extended use, it is often used in varying durations for supportive care for cancer patients with radiation-induced cystitis. The objective of this study was to compare the incidence of adverse drug reactions in patients with radiation cystitis receiving long-term phenazopyridine (>14-day supply) compared to a matched comparator group. Read More

Pediatr Int 2019 Jun 19;61(6):566-571. Epub 2019 Jun 19.

Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.

Background: The prognosis of high-risk neuroblastoma stage 4 with bone marrow metastasis, MYCN amplified, or refractory neuroblastoma is poor. To date, no standard treatment has been established. In four selected cases, we challenged the killer-cell immunoglobulin-like receptor ligand mismatch cord blood transplantation in graft-versus-host disease (GVHD) with reduced-intensity conditioning. Read More

Ann Surg Oncol 2020 Jan 8;27(1):171-178. Epub 2019 Apr 8.

Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Background: Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. Read More

Cancer Radiother 2019 Apr 18;23(2):151-160. Epub 2019 Mar 18.

Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, rue Albert-Raimond, 42270 Saint-Priest en Jarez, France.

Abdominal and pelvic irradiations play a major place in the management of patients with cancer and present a risk of acute and late side effects. Radiation-induced lesions can affect kidney or urological structures. These side effects can have an impact in the quality of life of patients. Read More

Front Oncol 2019 15;9:71. Epub 2019 Feb 15.

Academic Department of Radiation Oncology, Centre Oscar Lambret, Lille, France.

To report the preliminary results of salvage re-irradiation in the prostatic bed after radical prostatectomy and salvage external beam radiation therapy (EBRT) using robotic stereotactic body radiation therapy (SBRT) with Cyberknife® for local recurrence of prostate cancer. Retrospective monocentric analysis was performed on patients treated with SBRT for isolated macroscopic recurrence in the prostatic bed. All patients had radical prostatectomy and salvage or adjuvant EBRT. Read More

Can Urol Assoc J 2019 Feb;13(2):15-23

Department of Surgery (Urology) and Oncology, McMaster University, Hamilton, ON, Canada.

J Endourol 2019 02;33(2):99

Department of Urology, University of Washington, Seattle, Washington.

J Geriatr Oncol 2019 03 8;10(2):292-297. Epub 2019 Jan 8.

Department of Radiation Oncology, National University Cancer Institute, Singapore.

Background: Muscle invasive bladder cancer (MIBC) is prevalent in the older patients, who are a vulnerable population with multiple co-morbidities and at increased risk of complications. Radical cystectomy is often not suitable, hence radical radiotherapy (RT) is an alternative option. We reviewed the outcomes of older patients treated with RT with or without concurrent chemotherapy (CRT) at our institution. Read More

Radiol Med 2019 May 3;124(5):422-431. Epub 2019 Jan 3.

Department of Radiation Oncology, University of Florence, Florence, Italy.

Purpose: Prostatectomy, radiotherapy and watchful waiting are the main therapeutic options available for local stage of prostate cancer (PCa). We report our experience on 394 patients affected by prostate cancer primarily treated with high-dose, image-guided, IMRT, focusing on gastrointestinal, genitourinary toxicities and biochemical control.

Methods: From July 2003 to August 2014, 394 patients were treated with radical high-dose radiotherapy (HDRT) for prostate cancer; the mean total radiation dose was 79 Gy in standard fractions. Read More