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Hand (N Y) 2019 Apr 23:1558944719843643. Epub 2019 Apr 23.

1 Johns Hopkins University, Baltimore, MD, USA.

Appreciating the history of Hand Surgery is part of what most of us enjoy about our profession. Most of us know that Silas Weir Mitchell, MD, coined the terms "Causalgia" and "Phantom Limb," yet few of us know that our present-day evaluation of the sensory and motor function of the hand and some of our rehabilitation methods for motor palsy were introduced by Mitchell as he worked, scholarly, in Turner's Lane Hospital, the first hospital devoted to nerve injuries, to understand Civil War gunshot wounds related to musket ball. Mitchell's contributions to neurosensory and motor evaluation were reviewed by reading his historical publications. Read More

Neuromuscul Disord 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Avda Infante 553, Providencia, Santiago, Chile.

Bilateral simultaneous radial palsy is uncommon, and the few cases reported in the literature are due to compressive injuries, such as in the use of axillary crutch or birthing bar during labor. We present a patient who developed a severe bilateral palsy after playing in a dancing simulator machine. The patient's position during the game was a combination of wrist extension, elbow flexion, retroversion of arms and a degree of minor torsion of both upper limbs. Read More

J Am Acad Orthop Surg 2019 Mar 28. Epub 2019 Mar 28.

From the Orthopedic Department (Dr. Rubin, Dr. Orbach, Dr. Bor, and Prof. Rozen), Emek Medical Center, Afula, Israel, and the Faculty of Medicine (Dr. Rubin, Dr. Bor, and Prof. Rozen), Technion, Haifa, Israel.

Tardy ulnar nerve palsy is a chronic clinical condition characterized by a delayed onset ulnar neuropathy after an injury to the elbow. Typically, tardy ulnar nerve palsy occurs as a consequence of nonunion of pediatric lateral condyle fractures at the elbow, which eventually lead to a cubitus valgus deformity. While the child grows, the deformity worsens and the ulnar nerve is gradually stretched until classic symptoms of ulnar nerve neuropathy appear. Read More

Front Neurol 2019 12;10:216. Epub 2019 Mar 12.

Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, United States.

There are five sites at which radial nerve entrapment at the elbow has been commonly reported. These include the level of the fibrous bands within the extensor carpi radialis brevis, the thickened fascial tissue at the radiocapitellar joint, the leash of Henry, the arcade of Frohse, and the distal border of the supinator muscle. This review describes the anatomy of the radial nerve at the elbow and the surrounding structures, and then provides an overview of the literature supporting the use of ultrasound to assist in the evaluation of suspected radial neuropathy at the elbow. Read More

J Neurol 2019 Mar 25. Epub 2019 Mar 25.

Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.

Objective: Subclinical abnormalities, including microangiopathy, swelling of nerve fibers, visual field abnormalities and visual functional impairments had been reported in Leber's hereditary optic neuropathy (LHON) carriers. The purpose of this study was to investigate microstructural changes of brain white matter in asymptomatic LHON carriers using DTI and tract-based spatial statistics (TBSS).

Methods: DTI and neuro-ophthalmologic measurements were acquired in 14 LHON carriers and 15 gender- and age-matched healthy controls, and diffusion metrics, including fractional anisotropy (FA), axial (AD), radial diffusion (RD) and mean diffusion (MD) were calculated. Read More

Occup Environ Med 2019 May 8;76(5):326-331. Epub 2019 Mar 8.

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Objectives: The aim was to assess the association between occupational biomechanical exposure and the occurrence of radial nerve entrapment (RNE) in construction workers over a 13-year follow-up period.

Methods: A cohort of 229 707 male construction workers who participated in a national occupational health surveillance programme (1971-1993) was examined prospectively (2001-2013) for RNE. Height, weight, age, smoking status and job title (construction trade) were obtained on health examination. Read More

J Peripher Nerv Syst 2019 Mar 26;24(1):139-144. Epub 2019 Feb 26.

Univ. Limoges, MMNP, Limoges, France.

Neurofilaments are neuron-specific intermediate filaments essential for the radial growth of axons during development and the maintenance of axonal diameter. Pathogenic variants of Neurofilament Light (NEFL) are associated with CMT1F, CMT2E, and CMTDIG and have been observed in less than 1% of Charcot-Marie-Tooth (CMT) cases, resulting in the reporting of 35 variants in 173 CMT patients to date. However, only six variants have been reported in 17 patients with impaired hearing. Read More

J Shoulder Elbow Surg 2019 Feb 1. Epub 2019 Feb 1.

Center for Orthopedic and Trauma Surgery, University Medical Center of Cologne, Cologne, Germany.

Background: Radial head fractures lead to persisting disability in a considerable number of cases. This study aimed to investigate their most common revision causes and procedures.

Methods: This multicenter retrospective study reviewed the cases of 466 adult patients who had undergone surgical revision after operative or nonoperative treatment of a radial head fracture. Read More

Med Clin North Am 2019 Mar;103(2):357-370

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, WACC 739B, Boston, MA 02114, USA. Electronic address:

Upper extremity entrapment neuropathies are common and can cause pain, sensory loss, and muscle weakness that lead to functional disability. In this article, the authors review common entrapment neuropathies of the upper extremities, including median neuropathy at the wrist (carpal tunnel syndrome), ulnar neuropathy at the elbow, and radial neuropathy. The authors discuss the pathophysiology of nerve compression and typical etiologies, as well as strategies for differentiating between common mimics such as cervical radiculopathy and for selecting between various treatment modalities. Read More

J Hand Surg Am 2019 Jan 23. Epub 2019 Jan 23.

Department of Orthopaedic Surgery, Nippon Medical School, Tokyo, Japan.

Purpose: To determine clinical outcomes of Preiser disease treated with closing radial wedge osteotomy (CRWO).

Methods: Seven patients with Preiser disease underwent CRWO. Two wrists had stage 2 disease, 3 had stage 3, 2 had stage 4 (Herbert-Lanzetta classification). Read More

Muscle Nerve 2019 Apr 11;59(4):491-493. Epub 2019 Feb 11.

Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust.

Introduction: Electrophysiological diagnosis of axonal peripheral neuropathy (PN) is based on the attenuated amplitudes of nerve conduction studies (NCS), or a reduced sural/radial amplitude ratio (SRAR). We aimed to identify the electrophysiological determinants of the clinical severity of PN.

Methods: Patients with chronic axonal PN underwent detailed NCS. Read More

Clin Neurophysiol Pract 2018 3;3:159-163. Epub 2018 Nov 3.

Service of Neurology, University Hospital "Marqués de Valdecilla (IDIVAL)", University of Cantabria and "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)", Santander, Spain.

Objective: To describe the case of a patient with Guillain-Barré syndrome (GBS) showing early reversible conduction failure (RCF) detected by means of serial deep tendon reflex response (T-reflex) study.

Methods: A 36-year-old woman had a 5-day history of foot and hand paresthesias ascending to thighs and arms, throbbing interscapular and neck pain, mild to moderate tetraparesis, and areflexia. Nerve conduction studies (NCS) were performed on days 7 and 33 after onset. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13455

Department of Physical Medicine and Rehabilitation, Tung's Taichung Metroharbor Hospital, Taichung, Taiwan.

Rationale: Compressive radial neuropathy by a synovial cyst in the radial tunnel during pregnancy is a rare occurrence. The management of radial nerve compression caused by a synovial cyst in a pregnant patient is a surgical dilemma owing to the fetal and maternal risks of treatment.

Patient Concerns And Diagnosis: A 37-year-old pregnant woman presented with progressive forearm pain at the gestational age of 12 weeks. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(10):10-13

Medical Center 'Motus', Yaroslavl, Russia.

Aim: To describe the sonographic phenomenon of the focal 'hourglass-like constriction' of the peripheral nerves (FCPN).

Material And Methods: The authors described 7 patients meeting the criteria for the diagnosis of neuralgic amyotrophy with unilateral FCPN identified with ultrasound in 4 cases and detected intraoperatively in 3 cases (preliminary ultrasound was not performed). The US scanner Sonoscape Pro mode gray scale in the transverse and longitudinal scanning, linear probe 8-15 MHz and Logiq9 scanner with elastography were used. Read More

J Hand Surg Asian Pac Vol 2018 Dec;23(4):596-600

1 Department of Orthopaedics and Traumatology, North District Hospital, Hong Kong SAR, China.

Ganglion of the anterolateral elbow is rare and may be associated with compression neuropathy of the radial nerve or its branches. Open ganglionectomy implies extensive soft tissue dissection. We present a case of anterolateral elbow ganglion without any compression neuropathy. Read More

Cardiovasc Revasc Med 2018 Oct 25. Epub 2018 Oct 25.

Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, United States of America; Tufts University School of Medicine, MA, United States of America.

Background: The radial artery is the access of choice in many catheterization labs around the world due to its proven benefits over the femoral artery access. There has been growing interest in the left radial artery. We sought to evaluate the feasibility, safety and complication rates of the left distal radial artery (ldTRA) access for cardiac catheterization. Read More

Insights Imaging 2018 Dec 5;9(6):1021-1034. Epub 2018 Nov 5.

Department of Orthopaedics, SMS Medical College and Attached Hospitals, Jaipur, Rajasthan, India.

The radial nerve has a long and tortuous course in the upper limb. Injury to the nerve can occur due to a multitude of causes at many potential sites along its course. The most common site of involvement is in the proximal forearm affecting the posterior interosseous branch while the main branch of the radial nerve is injured in fractures of the humeral shaft. Read More

BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.

Ocular Oftalmologia, Vitória, Brazil.

Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More

Arch Phys Med Rehabil 2018 Oct 21. Epub 2018 Oct 21.

EMG Service, Local Health Unit 7, Siena, Italy.

Objective: The main objective is to investigate the diagnostic accuracy and the relation of touch sensation and subjective sensory symptoms in the medial aspect of the hand dorsum, and neurography of the dorsal ulnar cutaneous nerve (DUCN) in ulnar neuropathy at the elbow (UNE). Secondary objective is to report the electrophysiological occurrence of anatomical variant of sensory innervation of the medial aspect of the hand dorsum from superficial radial nerve (SRN).

Design: Prospective, cohort study. Read More

Eur J Neurol 2019 Mar 11;26(3):497-e36. Epub 2018 Dec 11.

Centre National de Référence pour la Neuropathie Amyloïde Familiale, CHU Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin- Bicêtre, France.

Background And Purpose: The aim is to describe an uncommon phenotype of hereditary ATTR neuropathy with upper limb onset.

Methods: The French TTR Familial Amyloid Polyneuropathy database was used for a retrospective evaluation of 32 consecutive patients with upper limb onset of the neuropathy (study group) and they were compared to 31 Portuguese early-onset patients and 99 late-onset patients without upper limb onset.

Results: Initial upper limb symptoms were mostly sensory. Read More

Clin Anat 2019 Jan 20;32(1):2-8. Epub 2018 Oct 20.

Department of Anesthesiology, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Our objective was to define the positions of the nerves around the brachial artery and, secondarily, to assess the risk of intraneural injection during dual guided axillary block. Sixty ultrasound-guided axillary blocks were performed. The locations of the musculocutaneous, median, ulnar, and radial nerves relative to the brachial artery were determined. Read More

Skeletal Radiol 2019 Apr 19;48(4):517-525. Epub 2018 Oct 19.

Orthopaedic Surgery, Georg-August Universität, Göttingen, Germany.

Background: Following the thalidomide disaster (1958-62), Henkel and Willert analysed the pattern of dysmelia in the long bones (J Bone Joint Surg Br. 51:399-414, 1969) and the extremities, Willert and Henkel (Z Orthop Ihre Grenzgeb. 107:663-75, 1970). Read More

Postgrad Med J 2018 Dec 19;94(1118):729. Epub 2018 Oct 19.

Department of Neurology, Lady Reading Hospital, Peshawar, Pakistan.

PM R 2019 Apr 22;11(4):436-439. Epub 2019 Feb 22.

Department of Physical Medicine and Rehabilitation, National Health Insurance Service Ilsan Hospital, 100 ilsan-ro ilsan-donggu Goyang-si Gyeonggi-do, 10444 South Korea.

Lymphedema is a condition characterized by localized fluid retention and tissue swelling caused by a compromised lymphatic system. To minimize fluid buildup and stimulate the flow of fluid through the lymphatic system, compression garments are usually applied to patients with lymphedema. There are few studies to report complications of compression garments to treat breast cancer-related lymphedema. Read More

Glia 2018 12 8;66(12):2632-2644. Epub 2018 Oct 8.

ETH Zurich, Department of Biology, Institute of Molecular Health Sciences, Zurich, Switzerland.

Proper function of the nervous system depends on myelination. In peripheral nerves, Schwann cells (SCs) myelinate axons and the miRNA biogenesis pathway is required for developmental myelination and myelin maintenance. However, regulatory roles of this pathway at different stages of myelination are only partially understood. Read More

BMC Cancer 2018 Oct 3;18(1):947. Epub 2018 Oct 3.

Department of Neurology, Semmelweis University, Balassa u. 6., H- 1083, Budapest, Hungary.

Background: Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of these, most frequently caused by a small lesion in the contralateral motor cortex of the brain. Read More

J Orthop Surg (Hong Kong) 2018 May-Aug;26(3):2309499018803002

2 Department of Anesthesiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Introduction: The prevalence of radial nerve injury during surgery is as high as the prevalence of radial nerve injury due to trauma. The aim of this study is to minimize the risk of iatrogenic injury of radial nerve.

Materials And Methods: Fifty patients with middle or distal diaphysis fractures of humerus and 18 patients with pseudoarthrosis at the same localizations were treated with surgery. Read More

Acta Ophthalmol 2019 Feb 26;97(1):e71-e76. Epub 2018 Sep 26.

Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

Purpose: In this prospective observational comparative case series, we aimed to study the peripapillary capillary network with spectral-domain optical coherence tomography angiography (OCT-A) in Leber hereditary optic neuropathy (LHON).

Methods: Twelve eyes of six individuals, of these three males (five eyes) after clinical onset of visual impairment were imaged by OCT-A with scans centred on optic discs. Control group consisted of 6 eyes with no visual impairment. Read More

Acta Chir Orthop Traumatol Cech 2018 ;85(3):199-203

Ortopedická klinika Lékařské fakulty Univerzity Karlovy a Fakultní nemocnice Hradec Králové.

PURPOSE OF THE STUDY When treating tears of the distal biceps brachii muscle tendon, we repeatedly noticed a difference between the preoperative ultrasound findings and the operative findings. The aim of the study was to retrospectively correlate these findings in order to determine the sensitivity of the ultrasound examination in everyday orthopaedic practice. Moreover, we compared the results and complications of surgical treatment through two operative techniques used at our department. Read More

Circ J 2018 Oct 22;82(11):2736-2744. Epub 2018 Sep 22.

Keele Cardiovascular Research Group, Keele University.

Background: We systematically reviewed the available literature on limb dysfunction after transradial access (TRA) or transfemoral access (TFA) cardiac catheterization. Methods and Results: MEDLINE and EMBASE were searched for studies evaluating any transradial or transfemoral procedures and limb function outcomes. Data were extracted and results were narratively synthesized with similar treatment arms. Read More

J Clin Neurophysiol 2018 Nov;35(6):474-480

Department of Neurology, Sohag University Hospital, Sohag University, Sohag, Egypt.

Purpose: Diabetes mellitus is a major public health problem. Diabetic polyneuropathy (DP) is one of the most common complications of diabetes mellitus. The early detection of DP is very important for timely treatment of symptoms and preventative foot care. Read More

Hum Mol Genet 2019 01;28(1):124-132

IRCCS San Raffaele Scientific Institute, DIBIT, Milan, Italy.

Protein zero (P0) is the major structural protein in peripheral myelin, and mutations in the Myelin Protein Zero (Mpz) gene produce wide-ranging hereditary neuropathy phenotypes. To gain insight in the mechanisms underlying a particularly severe form, congenital hypomyelination (CH), we targeted mouse Mpz to encode P0Q215X, a nonsense mutation associated with the disease, that we show escapes nonsense mediated decay and is expressed in CH patient nerves. The knock-in mice express low levels of the resulting truncated protein, producing a milder phenotype when compared to patients, allowing to dissect the subtle pathogenic mechanisms occurring in otherwise very compromised peripheral myelin. Read More

Childs Nerv Syst 2019 Jan 12;35(1):37-45. Epub 2018 Sep 12.

Department of Plastic Surgery, Hospital Universitario Central de Asturias, Oviedo, Spain.

Introduction: Entrapment neuropathies are infrequent in children, and therefore remain unrecognized. The incidence of radial, median, and cubital mononeuropathies are all similar. Despite the rarity of such cases, extensive, albeit scattered, literature has accumulated concerning entrapment neuropathies in children. Read More

Ann Rehabil Med 2018 Aug 31;42(4):601-608. Epub 2018 Aug 31.

Department of Rehabilitation Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objective: To determine a diagnostic cut-off value for the cross-sectional area (CSA) of the radial nerve using ultrasonography for radial neuropathy located at the spiral groove (SG).

Methods: Seventeen patients with electrodiagnostic evidence of radial neuropathy at the SG and 30 healthy controls underwent ultrasonography of the radial nerve at the SG . The CSAs at the SG were compared in the patient and control groups. Read More

Pan Afr Med J 2018 17;30:38. Epub 2018 May 17.

Orthopedic Surgery and Traumatology, Military Hospital Moulay Ismail, Meknes, Morocco.

We here report 54 cases of humerus diaphyseal fractures treated via Hackethal's bundle nailing. We observed 3 cases of radial nerve palsy. Therapeutic abstention associated with monitoring was the applied attitude toward these patients on presentation to the Emergency Department. Read More

Orthop Surg 2018 Aug;10(3):218-226

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: Iatrogenic radial nerve injury is a great challenge for orthopaedic surgeons who deal with distal-third diaphyseal humerus fractures. Conventional open reduction and internal fixation (ORIF) remains the gold standard, but complications such as nonunion and iatrogenic radial nerve injury still occur. We fixed the fractures with a lateral locking compression plate (LCP) subcutaneously after small incision reduction to protect the radial nerve. Read More

BMC Neurol 2018 Aug 21;18(1):120. Epub 2018 Aug 21.

Department of Neurology, Seoul Paik Hospital, Inje University College of Medicine, Mareunnae-ro 9, Jung-gu, Seoul, 04551, Republic of Korea.

Background: The motor and sensory symptoms caused by compressive radial neuropathy are well-known, but the involvement of the autonomic nervous system or the dermatologic symptoms are less well known. We report an unusual case of compressive radial neuropathy with reversible reddish skin color change.

Case Presentation: A 42-year-old man was referred for left wrist drop, finger drop and a tingling sensation over the lateral dorsum of the left hand. Read More

Bone Joint J 2018 08;100-B(8):1066-1073

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Aims: The aim of this study was to report the mid-term clinical outcome of cemented unlinked J-alumina ceramic elbow (JACE) arthroplasties when used in patients with rheumatoid arthritis (RA).

Patients And Methods: We retrospectively reviewed 87 elbows, in 75 patients with RA, which was replaced using a cemented JACE total elbow arthroplasty (TEA) between August 2003 and December 2012, with a follow-up of 96%. There were 72 women and three men, with a mean age of 62 years (35 to 79). Read More

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Orthopedic Trauma Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan.

Skeletal Radiol 2019 Jan 23;48(1):57-74. Epub 2018 Jul 23.

Department of Radiology, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St. Ste 800, Chicago, IL, 60616, USA.

Targeted ultrasound of the median, ulnar, and radial nerves is a well-established technique for suspected upper extremity peripheral neuropathy. However, sonographic imaging of the brachial plexus and smaller peripheral nerve branches is more technically difficult and the anatomy is less familiar to many radiologists. As imaging techniques improve, many clinicians refer patients for imaging of previously less-familiar structures. Read More

Hand (N Y) 2018 Jul 1:1558944718787282. Epub 2018 Jul 1.

2 Department of Orthopaedic Surgery, University of Chicago, IL, USA.

Background: The role of corticosteroid injections in the treatment of radial tunnel syndrome (RTS) has not been evaluated in depth. The purpose of this study was to evaluate the utility of a single corticosteroid injection as a therapeutic modality for RTS.

Methods: We enrolled 40 patients with a clinical diagnosis of RTS. Read More

Naunyn Schmiedebergs Arch Pharmacol 2018 10 4;391(10):1085-1092. Epub 2018 Jul 4.

Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, 3848176941, Iran.

Learning and memory deficits appear in chronic diabetes and valproic acid has been proved to be beneficial in neurodegenerative diseases. Hence, the current study investigated the effectiveness of chronic valproate treatment for diabetes-induced memory impairment and increased levels of hippocampal apoptotic caspases. This study was conducted in adult male C57B15/J mice. Read More

J Wrist Surg 2018 Jul 27;7(3):258-261. Epub 2017 Oct 27.

Department of Orthopaedic Surgery, Keck Medical Center of University of Southern California, Los Angeles, California.

 Arteriovenous malformations (AVMs) are commonly treated using endovascular techniques. Previous nerve palsies after embolization have been reported as isolated case reports, none of which affected the forearm.  A case of acute, transient neuropathy of the radial nerve following embolization of a forearm AVM is described. Read More

Pract Neurol 2018 Dec 12;18(6):520-521. Epub 2018 Jun 12.

Division of Neurology, Franz Tappeiner Hospital, Merano, Italy.

We describe a patient with pseudoradial nerve palsy caused by acute ischaemic stroke ('cortical hand') to emphasise how preserved synkinetic wrist extension following fist closure can distinguish this from peripheral causes of wrist drop. Read More

Medicine (Baltimore) 2018 Jun;97(23):e10978

Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Rationale: Perineural injection with dextrose could be a novel intervention for peripheral entrapment neuropathy. However, this intervention has not been reported for treating radial nerve palsy (RNP). Here, we present a case with RNP having outstanding improvement after 2 sessions of ultrasound-guided perineural injection with 5% dextrose (D5W). Read More

J Mol Biol 2018 Sep 1;430(19):3472-3480. Epub 2018 Jun 1.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Blvd, Memphis, TN 38105, USA. Electronic address:

In the course of their development from neuroepithelial cells to mature neurons, neuronal progenitors proliferate, delaminate, differentiate, migrate, and extend processes to form a complex neuronal network. In addition to supporting the morphology of the neuroepithelium and radial glia, polarity proteins contribute to the remodeling of processes and support the architectural reorganizations that result in axon extension and dendrite formation. While a good amount of evidence highlights a rheostat-like regulation by signaling events leading to local activation and/or redistribution of polarity proteins, recent studies demonstrate a new paradigm involving a switch-like regulation directly controlling the availability of polarity protein at specific stage by transcriptional regulation and/or targeted ubiquitin proteasome degradation. Read More

Clin Interv Aging 2018 22;13:1003-1010. Epub 2018 May 22.

Orthopaedics and Traumatology Department, Adana Numune Training and Research Hospital, Adana, Turkey.

Background: To evaluate the treatment efficacy and complications of the lateral minimally invasive plate osteosynthesis (MIPO) method in geriatric patients with a humerus diaphyseal fracture with proximal extension.

Patients And Methods: The study included a total of 21 patients (18 females, 3 males; mean age 74±6.3 years, range 65-89 years) who underwent surgery with the lateral MIPO technique for a humerus diaphyseal fracture with proximal extension during the period January 2011 to December 2016. Read More

J Neurosurg Anesthesiol 2018 May 21. Epub 2018 May 21.

Orthopedic Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Introduction: Peripheral nerve injury is a potentially devastating complication after total shoulder arthroplasty (TSA) surgery. This pilot study aimed to assess the feasibility of using an automated somatosensory evoked potential (SSEP) device to provide a timely alert/intervention to minimize intraoperative nerve insults during TSA surgery.

Methods: A prospective, single-arm, observational study was conducted in a single university hospital. Read More

Cureus 2018 Feb 16;10(2):e2199. Epub 2018 Feb 16.

Neurosurgery, Seattle Science Foundation.

Compression of the radial nerve is most commonly described at the supinator muscle (i.e., arcade of Frohse). Read More

Turk Kardiyol Dern Ars 2018 04;46(3):228-230

Department of Cardiology, Kartal Koşuyolu Yüksek İhtisas Training and Research Hospital, İstanbul, Turkey.

Coronary angiography and percutaneous coronary artery intervention are important tools for the diagnosis and treatment of coronary artery disease. Nevertheless, despite both technical and pharmacological advances, bleeding and vascular complications remain problematic. With recent trials supporting the safety and decreased bleeding risk associated with the radial approach, radial access has become more popular, and conferences providing instruction on this technique are often standing room only. Read More