Search Our Scientific Publications & Authors

Curr Eye Res 2021 May 12. Epub 2021 May 12.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: To compare the optic nerve head (ONH) structure and microvasculature in patients with optic atrophy due to non-arteritic anterior ischemic optic neuropathy (NAION), compressive optic neuropathy (CON), methanol-induced optic neuropathy (MION), and traumatic optic neuropathy (TON) using optical coherence tomography angiography.

Methods: In this comparative, cross-sectional study, 32 eyes with NAION, 18 eyes with CON, 32 eyes with MION, 23 eyes with TON, and 55 normal eyes were enrolled. Radial peripapillary capillary (RPC) vessel density, peripapillary retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, and cup/disc area ratio were obtained using the RTVue XR Avanti system (Optovue Inc. Read More

Eur J Neurol 2021 May 1. Epub 2021 May 1.

Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.

Background: The immunological pathophysiologies of chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) differ considerably, but neither has been elucidated completely. Quantitative magnetic resonance imaging (MRI) techniques as diffusion tensor imaging, T2 mapping, and fat fraction analysis may indicate in vivo pathophysiological changes in nerve architecture. Our study aims to systematically study nerve architecture of the brachial plexus in patients with CIDP, MMN, motor neuron disease (MND) and healthy controls using these quantitative MRI techniques. Read More

Curr Rev Musculoskelet Med 2021 Apr 23. Epub 2021 Apr 23.

Resurgens Orthopaedics, Atlanta, GA, USA.

Purpose: Radial tunnel syndrome is defined as a compressive neuropathy of the posterior interosseus nerve. It is differentiated from posterior interosseus nerve compression by symptom profile. The purpose of this article is to review past and current literature on the topic and determine if there are any emerging treatment options for this condition. Read More

J Hand Ther 2021 Jan 12. Epub 2021 Jan 12.

Department of Physical Medicine and Rehabilitation, Ankara Dışkapı Yıdırım Beyazıt Training and Research Hospital, University of Health Sciences Turkey, Ankara, Turkey.

Introduction: Patients with superficial radial neuropathy (SRN) have pain and abnormal sensation on the hand similar to hand osteoarthritis (HOA).

Purpose Of The Study: The aim of the present study was to evaluate the presence of SRN in patients with HOA and to determine the factors associated with electrophysiological parameters of the radial nerve.

Study Design: This is a case-control study. Read More

BMC Musculoskelet Disord 2021 Apr 7;22(1):337. Epub 2021 Apr 7.

School of Physical Therapy, Faculty of Health Science, Elborn College, Western University, London, ON, Canada.

Background: Carpal tunnel syndrome (CTS) is the most common entrapment mononeuropathy of the upper extremity. The previous systematic review of the diagnostic tests for CTS was outdated. The objective of this study was to compile and appraise the evidence on the accuracy of sensory and motor tests used for the diagnosis of CTS. Read More

Cureus 2021 Feb 26;13(2):e13570. Epub 2021 Feb 26.

Family Medicine, Des Moines University, Des Moines, USA.

Intraneural ganglion cysts are a rare occurrence. They are most commonly found originating from the common peroneal nerve but are also frequently reported on the radial, ulnar, median, sciatic, tibial, and posterior interosseous nerves. A typical clinical presentation is posterior knee and calf pain resulting from tibial neuropathy with preferential degeneration of the popliteus muscle. Read More

Muscle Nerve 2021 Mar 31. Epub 2021 Mar 31.

Section on Gastroenterology & Hepatology, Department of Internal Medicine, Wake Forest Baptist health, Winston Salem, North Carolina, USA.

Acute hepatic porphyrias are inherited metabolic disorders that may present with polyneuropathy, which if not diagnosed early can lead to quadriparesis, respiratory weakness, and death. Porphyric neuropathy is an acute to subacute motor predominant axonal neuropathy with a predilection for the upper extremities and usually preceded by a predominantly parasympathetic autonomic neuropathy. The rapid progression and associated dysautonomia mimic Guillain-Barré syndrome but are distinguished by the absence of cerebrospinal fluid albuminocytologic dissociation, progression beyond 4 wk, and associated abdominal pain. Read More

Unfallchirurg 2021 Mar 24. Epub 2021 Mar 24.

Klinik für Unfallchirurgie, Orthopädie, Plastische und Handchirurgie, Universitätsklinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

Background: In many cases the treatment of humeral shaft fractures is challenging and despite the large diversity of available approaches, no standard treatment exists. In addition to conservative treatment, intramedullary nails and plate osteosynthesis are competing methods for healing humeral shaft fractures. Furthermore, cerclage is considered to be an additive treatment for spiral fractures; however, this also increases the risk of radial nerve neuropathy and is said to compromise the perfusion of bone fragments. Read More

Neuroimage Clin 2021 Mar 8;30:102619. Epub 2021 Mar 8.

Department of Radiology & Tianjin Key Lab of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

Objective: The purpose of this study was to investigate whether the large-scale structural rich club organization was abnormal in patients with Leber's hereditary optic neuropathy (LHON) using diffusion tensor imaging (DTI), and the associations among disrupted brain structural connectivity, disease duration, and neuro-ophthalmological impairment.

Methods: Nineteen acute, 34 chronic LHON patients, and 36 healthy controls (HC) underwent DTI and neuro-ophthalmological measurements. The brain structural network and rich club organization were constructed based on deterministic fiber tracking at the individual level. Read More

Am J Case Rep 2021 Mar 18;22:e930277. Epub 2021 Mar 18.

Department of Special Surgery, Orthopaedic Division, Jordan University of Science and Technology, Irbid, Jordan.

BACKGROUND Supracondylar fracture is one of the most common pediatric traumatic fractures. It is subclassified into 2 entities: the extension type, which is predominantly seen, and the flexion type. It can be further classified into 4 types according to the Gartland classification, which assesses the anatomical severity of the fracture depending on the lateral radiographs of the elbow and operative findings. Read More

Cureus 2021 Feb 7;13(2):e13195. Epub 2021 Feb 7.

Neurology, Flowers Medical Group, Dothan, USA.

Saturday night palsy refers to neuropraxia of the radial nerve following prolonged compression against the spiral groove of the humerus. The pattern of weakness is unique with wrist, thumb, and finger drop, and recovery is universal by six months. What makes this clinical entity fascinating are the toxic and metabolic diseases that can manifest similarly, namely, plumbism (Saturnism) and acute porphyrias. Read More

J Equine Vet Sci 2021 03 6;98:103371. Epub 2021 Jan 6.

Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL.

A 4-year-old American Quarter Horse gelding was evaluated for acute non-weight-bearing lameness of the right thoracic limb with swelling in the right shoulder region. Physical examination revealed radial nerve paralysis of unknown etiology. The primary differential diagnosis was musculoskeletal trauma. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Mar 4. Epub 2021 Mar 4.

Department of Ophthalmology, Erzincan Binali Yildirim University School of Medicine, Erzincan, Turkey.

Purpose: This cross-sectional study compared the peripapillary vessel density (VD), peripapillary retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters between eyes with atrophic non-arteritic anterior ischemic optic neuropathy (NAION) and eyes with advanced primary open-angle glaucoma (POAG) matched for visual field mean deviation.

Methods: Peripapillary VDs and RNFL thicknesses in the peripapillary region, and 4 sectors (superior, inferior, nasal, and temporal), and scanning laser ophthalmoscopy parameters of the ONH were evaluated with optical coherence tomography angiography (OCTA) among 21 atrophic NAION cases, 26 advanced POAG cases, and 30 age- and sex-matched healthy controls.

Results: The POAG eyes had lower peripapillary VDs in all areas compared with the NAION eyes, which was most marked in the inferior and nasal sectors (p=0. Read More

Invest Ophthalmol Vis Sci 2021 Feb;62(2):42

Department of Ophthalmology III, Quinze-Vingts Hospital, IHU FOReSIGHT, Paris, France.

Purpose: The purpose of this study was to describe capillary changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography-angiography (OCT-A) and correlate the results with best corrected visual acuity (BCVA), visual field, OCT retinal nerve fiber layer (RNFL), and combined thickness of ganglion cell and inner plexiform layers (GCIPL) thicknesses.

Methods: We enrolled 22 eyes with acute NAION and 30 normal control (NC) subjects in this study. Whole en face image vessel density (WiVD) was measured in the radial peripapillary capillary plexus (RPC), superficial capillary plexus (SCP), and deep vascular complex (DVC) using OCT-A. Read More

J Neuroophthalmol 2021 02 19. Epub 2021 Feb 19.

Department of Clinical Neurological Sciences and Department of Ophthalmology (JAF), Western University, London, Canada; Department of Ophthalmology (PAS), State University of New York at Stony Brook, Stony Brook, New York; Moorfields Eye Hospital (AP), London, United Kingdom; Department of Neurology (AP), Amsterdam Neuroscience, VUmc MS Center Amsterdam and Dutch Expertise Centre for Neuro-ophthalmology, VU University Medical Centre, Amsterdam, The Netherlands; Institute of Neurology (AP), University College London, London, United Kingdom; Department of Eye Pathology (CT), UCL Institute of Ophthalmology, London, United Kingdom; Moorfields Eye Hospital (CT), London, United Kingdom; and Department of Ophthalmology (SH), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: With the development and widespread adoption of spectral-domain optical coherence tomography (OCT), peripapillary hyper-reflective ovoid mass-like structures (PHOMS) have become a frequent OCT finding in neuro-ophthalmic practice. Although originally assumed to represent a form of buried optic disc drusen (ODD), PHOMS differ from ODD in many important ways. The histopathological underpinnings of PHOMS are now becoming more clearly understood. Read More

J Hand Surg Asian Pac Vol 2021 Mar;26(1):96-99

Department of Orthopaedic Surgery, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Carpal tunnel syndrome (CTS) is the most common type of entrapment neuropathy. The majority of CTS cases are idiopathic and affect females between 40 and 60 years old. Conversely, this report describes two female patients in their mid-30's diagnosed with CTS caused by a median artery in the carpal tunnel using ultrasonography. Read More

Hand Surg Rehabil 2021 Apr 27;40(2):194-197. Epub 2021 Jan 27.

Acibadem Maslak Hospital, Department of Orthopedics and Traumatology, Darüşşafaka Büyükdere Caddesi No No:40, 34457 Sarıyer/Istanbul, Turkey.

Fibrodysplasia ossificans progressiva (FOP) is one of the genetic and developmental forms of heterotopic ossification. We report a case of FOP on the volar surface of the distal radius, located close to the median nerve and radial artery with neurologic symptoms secondary to median nerve entrapment. The patient underwent surgical excision of the heterotopic lesion followed by radiation therapy. Read More

Case Rep Neurol 2020 Sep-Dec;12(Suppl 1):207-211. Epub 2020 Dec 14.

Raffles Orthopaedic Centre, Raffles Hospital, Singapore, Singapore.

Wrist drops are usually due to a peripheral neuropathy affecting the radial nerve. Cortical wrist drops may occur, usually due to a lesion in the contralateral hand area of the motor cortex. We report a unique case of "cortical" wrist drop due to an acute infarction of the contralateral cerebral peduncle. Read More

Neurochirurgie 2021 Apr 22;67(2):170-175. Epub 2021 Jan 22.

Department of Hand Surgery, Shanghai Medical College, Fudan University, Huashan Hospital, 12, Wulumuqi Middle Road, 200040 Shanghai, China; Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Shanghai, China; State key laboratory of medical neurobiology, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Fudan University, Huashan Hospital, Shanghai, China; Priority Among Priorities of Shanghai Municipal Clinical Medicine Center, Shanghai, China; Institute of Engineering and Application Technology, Fudan University, Shanghai, China.

Introduction: Spontaneous radial nerve palsy with the surgical revelation of an hourglass-like constriction is a complicated condition. In general, the surgical strategy is decided in accordance with the results of surgical exploration. This study aimed to investigate the efficacies of various choices of surgical methods in the treatment of hourglass-like radial nerve constrictions. Read More

J Ophthalmol 2020 2;2020:3010631. Epub 2020 Nov 2.

Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.

Background: To analyze the blood flow changes of radial peripapillary capillaries (RPCs) and macula with time procession in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by optical coherence tomography angiography (OCT-A).

Methods: A total of 21 affected eyes and 19 unaffected eyes from 21 NAION patients were included. Assessments of BCVA, CFP, SD-OCT, and OCT-A were performed on NAION patients at enrollment and at 1-2 weeks, 1-2 months, and 3-6 months after enrollment. Read More

J Int Med Res 2021 Jan;49(1):300060520987938

Ministry of Health, Alexandria, Egypt.

Objective: This study was performed to examine the sonoelastographic features of the radial nerve in healthy subjects.

Methods: In this observational cross-sectional study, shear wave elastography was used to evaluate the radial nerve. The cross-sectional area and stiffness were measured. Read More

Muscle Nerve 2021 04 16;63(4):567-571. Epub 2021 Jan 16.

Academic Directorate of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: We aimed to describe the electrophysiological progression rate of chronic idiopathic axonal polyneuropathy (CIAP) and look into the potential role of human leukocyte antigen (HLA) genetic susceptibility in its development.

Methods: We recruited 57 patients with CIAP (mean age at diagnosis 67, mean follow-up 7 years). The assessments included clinical and electrophysiological data and HLA-DQ genotyping. Read More

Folia Morphol (Warsz) 2021 Jan 13. Epub 2021 Jan 13.

Department of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa, South Africa.

The ulnar nerve (UN), a terminal branch of the medial cord of the brachial plexus, is located posteromedial to brachial artery coursing along medially in the arm from the anterior to the posterior compartment through the arcade of Struthers. It passes posterior to medial epicondyle of humerus and enters the cubital tunnel. Thereafter, exiting through the distal part of the cubital fossa to enter the medial side of the forearm between the two heads of the flexor carpi ulnaris muscle underneath Osborne's ligament to enter the anterior compartment of the forearm. Read More

FP Essent 2021 Jan;500:33-41

West Virginia University Department of Human Performance, 1 Medical Center Dr, Morgantown, WV 26506.

Common chronic hand pathologies seen by family physicians include carpal tunnel syndrome, trigger finger, and de Quervain tenosynovitis. Carpal tunnel syndrome is the most common compressive neuropathy of the upper extremity and is caused by compression of the median nerve at the wrist. Trigger finger, also known as stenosing tenosynovitis, is caused by a metaplasia of the A1 flexor tendon pulley and the flexor tendon causing increased friction and decreased space for tendon gliding in the flexor tendon sheath. Read More

Cureus 2020 Dec 2;12(12):e11843. Epub 2020 Dec 2.

Orthopedics, Aster CMI Hospital, Bangalore, IND.

Epiphyseal injury involving both the radial and ulnar epiphysis at the wrist is rare and presents a diagnostic and therapeutic challenge. We report a case of a young adolescent female who presented with such an injury after a fall. She had a Salter-Harris Type 2 epiphyseal injury involving the distal end of both the radius and ulna. Read More

Int Ophthalmol 2021 Mar 3;41(3):1053-1061. Epub 2021 Jan 3.

Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Purpose: To analyze the vascular morphology changes after consumption of Ginkgo biloba in healthy volunteers by optical coherence tomography angiography (OCTA).

Methods: Sixty healthy volunteers without systemic and ocular disease were included in this prospective pilot study. After receiving the informed consent of the volunteers, Ginkgo biloba extract (120 mg oral capsule) was administered to sixty volunteers for 4 weeks, once a day in the morning. Read More

Autops Case Rep 2020 May 6;10(2):e2020153. Epub 2020 May 6.

Radiolinea Centro de Imagens. Brasília, DF, Brazil.

Compressive syndromes of peripheral nerves both in the upper and lower limbs are part of daily clinical practice; however, the etiological diagnosis can be challenging and impact on the outcome of the patient. We report five cases with rare etiologies of nerve entrapments: one in the lower limb and four in the upper limbs with the final diagnosis made only during the operation. The patients evolved without post-operative complications and had good outcomes. Read More

Turk J Ophthalmol 2020 10;50(5):313-316

Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

Leber's hereditary optic neuropathy (LHON) is thought to be a neurovascular disease due to presence of vascular changes in asymptomatic patients. Here we present 2 patients in whom optical coherence tomography angiography (OCTA) imaging demonstrated capillary drop-out areas and decreased radial peripapillary capillary (RPC) density in the quadrants that had thinner retinal nerve fiber layer (RNFL) in OCT images. Progressive decrease in RNFL and RPC density were shown in each patient at month 12 and 30 of follow-up. Read More

Clin Shoulder Elb 2020 Dec 26;23(4):183-189. Epub 2020 Nov 26.

Department of Orthopedic Surgery, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.

Background: The purpose of the current study was to investigate short- to mid-term outcomes and complications following radial head replacement (RHR) for complex radial head fractures and to identify factors associated with clinical outcomes.

Methods: Twenty-four patients with complex radial head fractures were treated by RHR. The mean age of the patients was 49. Read More

J Int Med Res 2020 Dec;48(12):300060520969043

Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, People's Republic of China.

An iatrogenic pseudoaneurysm of the radial artery and spontaneous venous malformation are associated with median nerve compression. However, the superficial brachial artery (SBA) has rarely been described as the cause of neurological deficits due to median nerve compression. A 61-year-old man was admitted to our clinic with a 1-year history of intermittent aching palsy in the left thumb that had progressed to the first three fingers. Read More