J Neuroophthalmol 2021 02 19. Epub 2021 Feb 19.
Department of Clinical Neurological Sciences and Department of Ophthalmology (JAF), Western University, London, Canada; Department of Ophthalmology (PAS), State University of New York at Stony Brook, Stony Brook, New York; Moorfields Eye Hospital (AP), London, United Kingdom; Department of Neurology (AP), Amsterdam Neuroscience, VUmc MS Center Amsterdam and Dutch Expertise Centre for Neuro-ophthalmology, VU University Medical Centre, Amsterdam, The Netherlands; Institute of Neurology (AP), University College London, London, United Kingdom; Department of Eye Pathology (CT), UCL Institute of Ophthalmology, London, United Kingdom; Moorfields Eye Hospital (CT), London, United Kingdom; and Department of Ophthalmology (SH), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Background: With the development and widespread adoption of spectral-domain optical coherence tomography (OCT), peripapillary hyper-reflective ovoid mass-like structures (PHOMS) have become a frequent OCT finding in neuro-ophthalmic practice. Although originally assumed to represent a form of buried optic disc drusen (ODD), PHOMS differ from ODD in many important ways. The histopathological underpinnings of PHOMS are now becoming more clearly understood. Read More