Search Our Scientific Publications & Authors

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, United States.

Background: The radial artery (RA) has been used for coronary artery bypass surgery for more than 25 years. The recent confirmation of the clinical benefits associated with the use of the artery is likely to drive a new interest toward this conduit in the next few years METHODS: A group of surgeons with extensive experience in the systematic use of the RA summarize here the key technical aspects of the use of the conduit for coronary bypass operations.

Results: Preoperative evaluation of the ulnar collateral circulation and attention to the characteristics of the target vessel are key for the successful use of the radial artery. Read More

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tuebingen, Germany.

Aim: Pharmacologic administration of insulin as nasal spray in humans has demonstrated a modulation of endogenous glucose production via the brain when systemic insulin levels are high. Results are conflicting under fasting insulin concentrations. To evaluate effects of brain insulin on endogenous glucose production in fasting humans with focus on hepatic glucose release, we performed a randomized, placebo controlled, blinded, cross-over experiment. Read More

J Comp Neurol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, School of Medicine, UC Davis, Davis, CA.

Cortical proliferative zones have been studied for over 100 years, yet recent data has revealed that microglial cells constitute a sizeable proportion of ventricular zone cells during late stages of cortical neurogenesis. Microglia begin colonizing the forebrain after neural tube closure and during later stages of neurogenesis populate regions of the developing cortex that include the proliferative zones. We previously showed that microglia regulate the production of cortical cells by phagocytosing neural precursor cells (NPCs), but how microglia interact with NPCs remains poorly understood. Read More

J Clin Monit Comput 2018 Dec 14. Epub 2018 Dec 14.

Department Anaesthesia and Intensive Care Units, Humanitas Research Hospital, Humanitas University, Milan, Italy.

To compare the effective arterial elastance (Ea) obtained from the arterial pressure with Ea calculated from left-ventricular (LV) pressure-volume analysis. Experimental study. LV pressure-volume data was obtained with a conductance catheter and arterial pressures were measured via a fluid-filled catheter placed in the proximal aorta, femoral and radial arteries. Read More

Eur J Hum Genet 2018 Dec 14. Epub 2018 Dec 14.

CHU Lille, Clinique de Génétique, 59000, Lille, France.

Holt-Oram syndrome (HOS) is an autosomal dominant condition characterised by the association of congenital heart defect (CHD), with or without rhythm disturbances and radial defects, due to TBX5 variants. The diagnosis is challenged by the variability of expression and the large phenotypic overlap with other conditions, like Okihiro syndrome, TAR syndrome or Fanconi disease. We retrospectively reviewed 212 patients referred for suspicion of HOS between 2002 and 2014, who underwent TBX5 screening. Read More

J Thorac Cardiovasc Surg 2018 Nov 14. Epub 2018 Nov 14.

Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Objective: Individual studies may be limited by sample size to detect differences in late survival between radial artery (RA) or saphenous vein graft (SVG) as a second conduit for coronary artery bypass surgery. Here we undertook a meta-analysis of the best evidence available on the comparison of early and late clinical outcomes of the RA and the SVG.

Methods: MEDLINE and EMBASE were searched for studies comparing use of the RA versus SVG for isolated coronary artery bypass surgery. Read More

J Thorac Cardiovasc Surg 2018 Nov 14. Epub 2018 Nov 14.

Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.

Objective: The long-term benefits of multiple arterial revascularization (MAR) in coronary artery bypass grafting remain uncertain. The aim of this study was to investigate the clinical outcome, graft patency, and need for subsequent target revascularization of radial artery (RA) versus saphenous vein graft in patients undergoing MAR in both patient- and graft-specific analyses.

Methods: Between 2001 and 2016, we followed 1654 patients over a median of 7. Read More

J Phys Chem B 2018 Dec 14. Epub 2018 Dec 14.

The drying and crystallisation of solution droplets is a problem of broad relevance, determining the micro-structures of particles formed in spray drying, the phase of particles delivered by, for example, aerosol formulations for inhalation therapies, and the impact of aerosols on radiative forcing and climate. The ephemeral nature of free-droplets, particularly when considering the drying kinetics of droplets with highly volatile constituents, has often precluded the accurate measurement of transient properties such as droplet size and composition, preventing the robust assessment of predictive models of droplet drying rates, nucleation and crystallisation. Here, we report novel measurements of the drying kinetics of individual aqueous sodium chloride solution droplets using a comparative-kinetics electrodynamic balance to isolate and trap single aerosol droplets (radius ~ 25 µm). Read More

Insect Sci 2018 Dec 14. Epub 2018 Dec 14.

CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.

Identification of stage- and tissue-specific cis-regulatory elements will enable more precise genomic editing. In previous studies of the silkworm Bombyx mori, we identified and characterized several tissue and sex-specific cis-regulatory elements using transgenic technology, including a female- and fat body-specific promoter, vitellogenin; testis-specific promoters, Radial spoke head 1 (BmR1) and beta-tubulin 4 (Bmβ4). Here we reported a cis-regulatory element specific for a somatic and germ cell expressed promoter, nanos (Bmnos). Read More

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Intellectual disability (ID), a genetically and clinically heterogeneous disorder, affects 1%-3% of the general population and is a major health problem, especially in developing countries and in populations with a high frequency of consanguineous marriage. Using whole exome sequencing, a homozygous missense variation (c.3264G>C, p. Read More

J Anat 2018 Dec 13. Epub 2018 Dec 13.

Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.

The objective of this paper was to collect normative data essential for analyzing the subplate (SP) role in pathogenesis of developmental disorders, characterized by abnormal circuitry, such as hypoxic-ischemic lesions, autism and schizophrenia. The main cytological features of the SP, such as low cell density, early differentiation of neurons and glia, plexiform arrangement of axons and dendrites, presence of synapses and a large amount of extracellular matrix (ECM) distinguish this compartment from the cell-dense cortical plate (CP; towards pia) and large fiber bundles of external axonal strata of fetal white matter (towards ventricle). For SP delineation from these adjacent layers based on combined cytological criteria, we analyzed the sublaminar distribution of different microstructural elements and the associated maturational gradients throughout development, using immunocytochemical and histological techniques on postmortem brain material (Zagreb Neuroembryological Collection). Read More

Am J Med Genet A 2018 Dec 12:e40530. Epub 2018 Dec 12.

Laboratoire de Génétique Médicale, Faculté de Médecine, Université de Strasbourg, Strasbourg cedex, France.

Anorectal anomalies (ARA) are common congenital anomalies. The etiology of ARA is unclear and its pathogenesis is controversial. Cases with ARA often have other non-ARA-associated congenital anomalies. Read More

New Phytol 2018 Dec 12. Epub 2018 Dec 12.

Department of Plant Developmental Biology, Institute of Experimental Biology, Faculty of Biological Sciences, University of Wrocław, Kanonia 6/8, 50-328, Wrocław, Poland.

In trees, dead and living cells of secondary xylem (wood) function collectively, rendering cell-to-cell communication challenging. Water and solutes are transported over long distances from the roots to the aboveground organs via vessels, the main component of wood, and then radially over short distances to the neighboring cells. This enables proper functioning of trees and integrates whole-plant activity. Read More

Dev Neurobiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology, University of North Florida, Jacksonville, Florida.

Radial glial cells are crucial in vertebrate neural development and regeneration. It has been recently proposed that this neurogenic cell type might be older than the chordate lineage itself and might have been present in the last common deuterostome ancestor. Here, we summarize the results of recent studies on radial glia in echinoderms, a highly regenerative phylum of marine invertebrates with shared ancestry to chordates. Read More

Adv Healthc Mater 2018 Dec 12:e1801160. Epub 2018 Dec 12.

Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.

Chronic tympanic membrane (TM) perforations can cause otorrhea. To date, various types of tissue engineering techniques have been applied for the regeneration of chronic TM perforations. However, the application of nanofibers with radially aligned nanostructures and the simultaneous release of growth factors have never been applied in the regeneration of chronic TM perforations. Read More

Acta Anaesthesiol Scand 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Germany.

Background: Remote ischaemic preconditioning (RIPC) can attenuate myocardial ischaemia/reperfusion injury but its underlying mechanisms remain largely unknown. Recently, extracellular vesicles (EVs) containing microRNAs (miRNAs) were shown to mediate distant intercellular communication that may be involved in cardioprotection. We tested the hypothesis that RIPC in anaesthetized patients undergoing coronary artery bypass (CABG) surgery results in the release of EVs from the ischaemic/reperfused arm into the blood stream harbouring cardioprotective miRNAs. Read More

Catheter Cardiovasc Interv 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardiology, Ehime Niihama Prefectural Hospital, Niihama, Ehime, Japan.

Background: Temporary pace maker is necessary because of transient block or bradycardia during the intracoronary acetylcholine spasm provocation tests based on the Japanese Circulation Society guidelines.

Objectives: We examined the feasibility and safety of the acetylcholine spasm provocation test via the radial artery and brachial vein approach.

Methods: We tried to perform the acetylcholine spasm provocation tests in 252 patients via the radial artery and brachial vein approach procedures during 5 years. Read More

Opt Lett 2018 Dec;43(24):6101-6104

We propose and demonstrate a simple and easy-to-implement projective-measurement protocol to determine the radial index p of a Laguerre-Gaussian (LGpl) mode. Our method entails converting any specified high-order LGp0 mode into a near-Gaussian distribution that matches the fundamental mode of a single-mode fiber (SMF) through the use of two phase screens (unitary transforms) obtained by applying a phase-retrieval algorithm. The unitary transforms preserve the orthogonality of modes before the SMF and guarantee that our protocol can, in principle, be free of crosstalk. Read More

Phys Rev Lett 2018 Nov;121(22):225001

Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08544, USA.

Currents driven by radio frequency (rf) waves in the interior of magnetic islands can stabilize deleterious tearing modes in tokamaks. Present analyses of stabilization assume that the local electron acceleration is unaffected by the presence of the island. However, the power deposition and electron acceleration are sensitive to the perturbation of the temperature. Read More

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):292-295. Epub 2018 Dec 4.

Division of Vascular Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.

Radial artery aneurysms are exceedingly rare, with only a few reported cases of surgical revascularization. We describe a 25-year-old man who presented with severe ischemia of the right hand secondary to an idiopathic true radial artery aneurysm at the anatomic snuff box. The patient had embolic occlusions in his hand and fingers that were treated with catheter-directed thrombolysis. Read More

Front Physiol 2018 28;9:1691. Epub 2018 Nov 28.

Department of Biology, Mount Royal University, Calgary, AB, Canada.

Neurovascular coupling (NVC) is the temporal link between neuronal metabolic activity and regional cerebral blood flow (CBF), supporting adequate delivery of nutrients. Exposure to high altitude (HA) imposes several stressors, including hypoxia and hypocapnia, which modulate cerebrovascular tone in an antagonistic fashion. Whether these contrasting stressors and subsequent adaptations affect NVC during incremental ascent to HA is unclear. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13455

Department of Physical Medicine and Rehabilitation, Tung's Taichung Metroharbor Hospital, Taichung, Taiwan.

Rationale: Compressive radial neuropathy by a synovial cyst in the radial tunnel during pregnancy is a rare occurrence. The management of radial nerve compression caused by a synovial cyst in a pregnant patient is a surgical dilemma owing to the fetal and maternal risks of treatment.

Patient Concerns And Diagnosis: A 37-year-old pregnant woman presented with progressive forearm pain at the gestational age of 12 weeks. Read More

J Neurosurg 2018 Dec;129(Suppl1):125-132

OBJECTIVEThe aim of this study was to compare 3 different methods to assess the geometrical distortion of two 1.5-T and one 3-T magnetic resonance (MR) scanners and to evaluate co-registration accuracy. The overall uncertainty of each particular method was also evaluated. Read More

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Plasmonic material has been emerged with multi-functionalities for its remarkable tailoring light emission, reshaping density of states (DOS) and focusing subwavelength light. However, restricted by its propagation loss and narrowband resonance in nature, it is a challenge issue for plasmonic material to provide a broadband DOS to advance its application. Here, we develop a novel nanoscale core-shell hyperbolic structure that possesses a remarkably coupling effect inside the multishell nanoscale composite owing to a higher DOS and longer time of collective oscillations of the electrons than the plasmonic-based pure metal nanoparticles. Read More

MAGMA 2018 Dec 12. Epub 2018 Dec 12.

Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Objective: To refine a new technique to measure respiratory-resolved left ventricular end-diastolic volume (LVEDV) in mid-inspiration and mid-expiration using a respiratory self-gating technique and demonstrate clinical feasibility in patients.

Materials And Methods: Ten consecutive patients were imaged at 1.5 T during 10 min of free breathing using a 3D golden-angle radial trajectory. Read More

Surg Radiol Anat 2018 Dec 12. Epub 2018 Dec 12.

Center for Orthopedic and Trauma Surgery, University Medical Center, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Purpose: Radial head fractures are regularly treated with radial head arthroplasty. To prevent limited motion or pain, the implant's size should match its normal anatomy. Preoperative estimation of the radial head size helps in finding the correct head component. Read More

Rev Esp Cir Ortop Traumatol 2018 Dec 9. Epub 2018 Dec 9.

Ortopedia y Traumatología, Universidad Nacional de Colombia, Bogotá, Colombia.

Introduction: radial longitudinal deficiency (RLD) includes bone, musculotendinous and neurovascular abnormalities of multifactorial aetiology of the radial side of the upper extremity. Treatment includes improving the length of the limb, the appearance and functioning of the hand. The aim of this study was to present our experience in a series of patients attended over the past 15 years and to describe the clinical and radiological results. Read More

J Neural Eng 2018 Oct 24. Epub 2018 Oct 24.

Delsys Inc. and Altec Inc., Natick, Massachusetts, UNITED STATES.

Objective: Modern prosthetic limbs have made strident gains in recent years, incorporating terminal electromechanical devices that are capable of mimicking the human hand. However, access to these advanced control capabilities has been prevented by fundamental limitations of neural interfaces, which have remained virtually unchanged for nearly five decades. Consequently, nearly 23% of adults and 32% of children with major traumatic or congenital upper-limb loss abandon regular use of their myoelectric prostheses. Read More

Phys Med Biol 2018 Dec 7;63(24):24NT01. Epub 2018 Dec 7.

Division of Informatics, Imaging and Data Sciences, MAHSC, University of Manchester, Manchester, United Kingdom. Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom. Author to whom any correspondence should be addressed.

In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources. For gallium-68, this required modification of the original design to handle its longer positron range. Read More

Nanotechnology 2018 Nov 26. Epub 2018 Nov 26.

Institut des Nanotechnologies de Lyon, Ecully, FRANCE.

With a band gap value of 1.7 eV, Al0.2Ga0. Read More

J Phys Condens Matter 2018 Nov 26. Epub 2018 Nov 26.

Computational Materials Physics Research Group & Faculty of Applied Sciences, Ton Duc Thang University, 19 Nguyen Huu Tho Street, Tan Phong Ward, District 7, Ho Chi Minh City, 700000, VIET NAM.

This molecular dynamics (MD) simulation carries a detailed analysis of a pressure-induced structural transition supercooled liquid and amorphous silicene (a-silicene). Low-density models of supercooled liquid and a-silicene containing 10000 atoms are obtained by rapid cooling process from the melts. Then, a-silicene model at T = 1000K, supercooled liquid model at T = 1500K and liquid silicon model at T = 2000K have been isothermal compressed step by step up to a high density in order to observe the pressure-induced structural changes. Read More

Phys Med Biol 2018 Nov 22. Epub 2018 Nov 22.

Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, Florida, UNITED STATES.

Mammograms represent data that can inform future risk of breast cancer. Data from two case-control study populations were analyzed. Population 1 included women (N = 180 age matched case-control pairs) with mammograms acquired with one indirect x-ray conversion mammography unit. Read More

Nanotechnology 2019 Feb;30(6):065602

Center for Micro- and Nanostructures, Institute for Solid State Electronics, TU Wien, A-1040 Vienna, Austria.

The addition of boron to GaAs nanowires grown by self-catalyzed molecular beam epitaxy was found to have a strong effect on the nanowire morphology, with axial growth greatly reduced as the nominal boron concentration was increased. Transmission electron microscopy measurements show that the Ga catalyst droplet was unintentionally consumed during growth. Concurrent radial growth, a rough surface morphology and tapering of nanowires grown under boron flux suggest that this droplet consumption is due to reduced Ga adatom diffusion on the nanowire sidewalls in the presence of boron. Read More

Dev Cell 2018 Dec 25;47(5):576-591.e8. Epub 2018 Oct 25.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

The Hippo pathway controls the activity of YAP/TAZ transcriptional coactivators through a kinase cascade. Despite the critical role of this pathway in tissue growth and tumorigenesis, it remains unclear how YAP/TAZ-mediated transcription drives proliferation. By analyzing the effects of inactivating LATS1/2 kinases, the direct upstream inhibitors of YAP/TAZ, on mouse brain development and applying cell-number-normalized transcriptome analyses, we discovered that YAP/TAZ activation causes a global increase in transcription activity, known as hypertranscription, and upregulates many genes associated with cell growth and proliferation. Read More

Brain Nerve 2018 Dec;70(12):1381-1388

Laboratory for Local Neuronal Circuits, RIKEN Center for Brain Science.

The mammalian neocortex contains diverse cell types but whether they organize into repeated modular circuits remains unknown. We discovered that major cell types in neocortical layer 5 form a lattice structure in many areas of the brain. Large-scale three-dimensional imaging revealed that distinct types of excitatory and inhibitory neurons form cell type-specific radial clusters termed microcolumns. Read More

Rev Esp Cir Ortop Traumatol 2018 Dec 3. Epub 2018 Dec 3.

Servicio de Cirugía Ortopédica y Traumatología, Hospital Clínico, Barcelona, España.

Objective: The management of MasonII fracture pattern assisted by arthroscopy is a valid technique that provides good results. The objective of this study was to draw attention to the usefulness of the location of the fracture in the head of the radius in defined quadrants with respect to the bicipital tuberosity through CT. This would help to plan the optimal forearm position to access each quadrant and foresee the specific difficulties of each one. Read More

J Orthop Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.

Background: While limb elevation and other methods for reducing hand edema are commonly used in clinical practice, alternative methods, such as compression and venous perfusion assist system (VPAS), have emerged. This study compared the efficacy of VPAS to limb elevation in decreasing hand edema after surgery for distal radial fracture (DRF) treated by a volar locking plate (VLP).

Methods: A randomized controlled trial was conducted in 102 patients to compare VPAS and elevation methods for edema reduction following VLP fixation for DRF. Read More

J Acoust Soc Am 2018 Nov;144(5):EL465

U.S. Army Research Laboratory, 2800 Powder Mill Road, Adelphi, Maryland 20783-1123, USA

In this work, the application of the cross-correlation Green's function retrieval method for source localization and atmospheric acoustic tomography is presented. Open field experimental measurements of an acoustic source, with an impulsive waveform, are conducted for the evaluation of an array system. Of particular interest are the source localization and sound speed estimation capabilities of the array system. Read More

Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anaesthesia, Burn, and Critical Care, Saint-Louis Lariboisière University Hospital (RB, FD, MR, JS, AM, BGC), Department of Anaesthesia and Critical Care, European Hospital Georges-Pompidou, APHP (AN, DD, RP), Paris Diderot University, Sorbonne Paris Cité (AM, BGC), Inserm U942 (AM), Paris Descartes University, Sorbonne Paris Cité (RP), Inserm U1153 (RP) and Inserm U1160, Paris, France (BGC).

Background: The ability of the pressure recording analytical method (PRAM) in tracking change in cardiac output (ΔCO) after a fluid challenge in ICU needs to be evaluated with the most contemporary comparison methods recommended by experts.

Objective: Our objective was to report the trending ability of PRAM in tracking ΔCO after a fluid challenge in ICU and to compare this with oesophageal Doppler monitoring (ODM).

Design: Prospective, observational study. Read More

Rev Esc Enferm USP 2018 Dec 10;52:e03410. Epub 2018 Dec 10.

Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

Objective: To examine the incidence of hemorrhagic complications in patients undergoing radial cardiac catheterization and using a hemostatic device for arterial compression.

Method: A prospective cohort study conducted with patients undergoing elective cardiac catheterization in two hemodynamic laboratories in southern Brazil. The TR Band® radial compression device was used during 4 hours for hemostasis of the arterial puncture site. Read More

Soft Matter 2018 Dec 12. Epub 2018 Dec 12.

Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA.

We study the periodic buckling patterns that emerge when elastic shells are subjected to geometric confinement. Residual swelling provides access to range of shapes (saddles, rolled sheets, cylinders, and spherical sections) which vary in their extrinsic and intrinsic curvatures. Our experimental and numerical data show that when these moderately thick structures are radially confined, a single geometric parameter - the ratio of the total shell radius to the amount of unconstrained material - predicts the number of lobes formed. Read More

Neuroradiology 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Purpose: Quantitative susceptibility mapping (QSM) is influenced by iron as well as myelin, which makes interpretation of pathologic changes challenging. Concurrent acquisition of MR sequences that are sensitive to axonal/myelin integrity, such as diffusion tensor imaging (DTI), may provide context for interpreting quantitative susceptibility (QS) signal. The purpose of our study was to investigate alterations in normal-appearing white matter (NAWM) in multiple sclerosis (MS) using QSM in conjunction with DTI. Read More

Adv Hematol 2018 13;2018:4716370. Epub 2018 Nov 13.

KINESTASIS Seedlings of Research, University of Cundinamarca, Fusagasugá, Colombia.

In the field of medicine, the analysis of blood is one of the most important exams to determine the physiological state of a patient. In the analysis of the blood sample, an important process is the counting and classification of white blood cells, which is done manually, being an exhaustive, subjective, and error-prone activity due to the physical fatigue that generates the professional because it is a method that consumes long laxes of time. The purpose of the research was to develop a system to identify and classify blood cells, by the implementation of the networks of Gaussian radial base functions (RBFN) for the extraction of its nucleus and subsequently their classification through the morphological characteristics, its color, and the distance between objects. Read More

Appl Clin Genet 2018 23;11:157-162. Epub 2018 Nov 23.

Center for Research on Congenital Anomalies and Rare Diseases (CIACER), Department of Basic Medical Sciences, Universidad Icesi, Cali, Valle del Cauca, Colombia,

Holt-Oram syndrome (HOS) is an autosomal dominant disorder characterized by congenital cardiac defects and congenital deformities of the upper limbs. Herein, we report the case of a 2-year-old patient presenting with clinical diagnostic criteria of HOS with interatrial and interventricular communication associated with hip dysplasia and upper limb reduction composed of radial ray anomaly. A novel de novo, potentially pathogenic variant in the gene at NM_181486. Read More

J Chem Theory Comput 2018 Dec 11. Epub 2018 Dec 11.

Molecular simulations provide insight into solvation structures and dynamics with unparalleled spatial and temporal resolution. Here, we take advantage of this fact and develop a set of generally applicable computational tools for a detailed analysis of the hydration shell around an ionic or molecular solute. These tools allow us to quantify and visualize orientationally-resolved radial distribution functions as well as distance-resolved orientational time-correlation functions of water molecules surrounding the solute. Read More

Anat Rec (Hoboken) 2018 Dec 8. Epub 2018 Dec 8.

Department of Anthropology, The Ohio State University, 4034 Smith Laboratory, 174 West 18th Ave., Columbus, OH 43210, USA.

Dental replicas are frequently utilized in paleoanthropological studies of perikymata and enamel hypoplasia. However, fossil teeth are often fragile and worn, causing two problems: (1) the risk of damage by removing enamel fragments when impression-making material is separated from the fossil tooth surface, and (2) the need to reconstruct worn portions of the crown to assess perikymata number, distribution, and hypoplasia timing. This study presents the advantages of μCT data of canines and lateral incisors for (1) detecting cracks along the enamel-dentine junction (EDJ) which could cause damage when casting, and (2) reliably and non-destructively reconstructing worn or broken cusps. Read More

Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.

Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.

Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More

Biopolymers 2018 Dec 8:e23241. Epub 2018 Dec 8.

Department of Micro- and Nanotechnology, The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Technical University of Denmark, Kongens Lyngby, Denmark.

Cell or tissue stretching and strain are present in any in vivo environment, but is difficult to reproduce in vitro. Here, we describe a simple method for casting a thin (about 500 μm) and soft (about 0.3 kPa) hydrogel of gelatin and a method for characterizing the mechanical properties of the hydrogel simply by changing pressure with a water column. Read More

Catheter Cardiovasc Interv 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, American Hospital of Paris and Hôpital Foch, Suresnes, France.

Since its introduction by Lucien Campeau three decades ago, percutaneous radial artery approach at the forearm has been shown to provide advantages over the femoral approach and has become the standard approach for coronary angiography and intervention. Though infrequent, vascular complications still remain, mainly radial artery occlusion. Therefore, a more distal radial approach at the snuffbox or at the dorsum of hand has been suggested, initially by anethesiologists for perioperative patient monitoring, and more recently by Babunashvili et al. Read More

Catheter Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Interventional Cardiology Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy.

Background: Trans-catheter closure of coronary artery fistulae (CAF) has become a successful alternative to cardiac surgery with excellent results and acceptable low rate of complications. Different techniques and devices are available to treat the extreme anatomical variability of CAF.

Aim: We retrospectively describe our case series of five patients trans-radially treated using an Amplatzer vascular plug IV (AVP-IV) with telescoping catheter technique. Read More