15,142 results match your criteria Rabies


Generation of Monoclonal Antibodies against Variable Epitopes of the M Protein of Rabies Virus.

Viruses 2019 Apr 23;11(4). Epub 2019 Apr 23.

MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

Rabies virus (RABV), the causative agent of rabies, is highly neurovirulent for warm-blooded animals with a mortality rate of up to 100%. The RABV matrix protein (M) is required for virus particle assembly and budding. However, little is known about antigenic differences in the M protein. Read More

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https://www.mdpi.com/1999-4915/11/4/375
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http://dx.doi.org/10.3390/v11040375DOI Listing
April 2019
1 Read

Rabies-based vaccine induces potent immune responses against Nipah virus.

NPJ Vaccines 2019 15;4:15. Epub 2019 Apr 15.

1Department of Microbiology and Immunology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107 USA.

Nipah Virus (NiV) is a re-emerging zoonotic pathogen in the genus of the family of viruses. NiV is endemic to Bangladesh and Malaysia and is highly fatal to both livestock and humans (human case fatality rate = 74.5%). Read More

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http://www.nature.com/articles/s41541-019-0109-5
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http://dx.doi.org/10.1038/s41541-019-0109-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465360PMC
April 2019
1 Read

Ascending vestibular pathways to parietal areas MIP and LIPv and efference copy inputs from the medial reticular formation: functional frameworks for body representations updating and online movement guidance.

Eur J Neurosci 2019 Apr 23. Epub 2019 Apr 23.

Department of Physiology and Biophysics, Howard University, Washington, DC, USA.

The posterior parietal cortex (PPC) serves as a sensorimotor interface by integrating multisensory signals with motor related information for generating and updating body representations and movement plans. Using retrograde transneuronal transfer of rabies virus combined with a conventional tracer, we identified direct and polysynaptic pathways to two PPC areas, the rostral medial intraparietal area (MIP) and the ventral part of the lateral intraparietal area (LIPv) in macaque monkeys. We found that rostral MIP and LIPv receive ascending vestibular pathways, and putative efference copy inputs disynaptically from the medullary medial reticular formation (MRF) where reticulospinal pathways to neck and arm motoneurons originate. Read More

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http://dx.doi.org/10.1111/ejn.14426DOI Listing

Evaluation of Different Stabilizers and Inactivating Compounds for the Enhancement of Vero Cell Rabies Vaccine Stability and Immunogenicity: Study.

Biomed Res Int 2019 17;2019:4518163. Epub 2019 Mar 17.

Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia.

Inactivation of rabies virus is essential for rabies vaccine preparation where the inactivating compound that is currently recommended for rabies vaccine preparation is -propiolactone (-PL). This compound is considered better than phenol and formalin but it is expensive and potentially carcinogenic. Data revealed that Ascorbic acid (AA) with cupric ions could yield complete and irreversible inactivation of rabies virus without adversely affecting its antigenicity. Read More

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http://dx.doi.org/10.1155/2019/4518163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441502PMC

Raccoon rabies outbreak in Hamilton, Ontario: A progress report.

Can Commun Dis Rep 2018 May 3;44(5):116-121. Epub 2018 May 3.

Region of Peel, Mississauga, ON.

Background: Raccoon rabies is caused by a variant of the rabies virus found in raccoons but transmissible to other mammalian species, including humans. The disease of rabies caused by raccoon variant rabies virus is indistinguishable from rabies caused by other rabies virus variants.

Objective: This paper describes the raccoon rabies outbreak in Ontario (identified in December 2015) and the control measures undertaken to curb the spread of the epizootic using the One Health approach. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449115PMC

Timing of Intradermal Rabies Pre-exposure Prophylaxis Injections: Immunological Effect on Vaccination Response.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Travel Clinic, Centre for Infectious Diseases, Military Hospital Queen Astrid, Rue Bruyn 1, 1120 Neder-Over-Heembeek, Belgium.

Introduction: Rabies remains a global threat, with annually over 59,000 deaths. Intradermal (ID) pre-exposure prophylaxis (PrEP) is very efficient and reduces the need for rabies immunoglobulins. Not much is known about factors that influence the immune response to ID administered rabies vaccine. Read More

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http://dx.doi.org/10.1093/milmed/usz048DOI Listing

Rabies Acquired through Mucosal Exposure, China, 2013.

Emerg Infect Dis 2019 May;25(5):1028-1029

In China in 2013, a man acquired rabies after sucking wounds of his son, who had been bitten by a stray dog. The man declined postexposure prophylaxis (hyperimmunoglobulin and vaccine) and died; the son accepted prophylaxis and survived. Physicians should be aware of rabies transmission through mucosal exposure and encourage postexposure prophylaxis. Read More

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http://dx.doi.org/10.3201/eid2505.181413DOI Listing

Novel Circo-Like Virus Detected in a Croatian Bat Population.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Department of Virology, Croatian Veterinary Institute, Zagreb, Croatia

Viral metagenomics analysis of samples from bats has been carried out as part of bat rabies surveillance in Croatia. Here, we report the complete genome sequence of a novel circo-like virus isolated from a sample of bat guano determined by Illumina next-generation sequencing. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.00280-19
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http://dx.doi.org/10.1128/MRA.00280-19DOI Listing
April 2019
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Two fatal cases of rabies in humans who did not receive rabies postexposure prophylaxis in Nigeria.

Clin Case Rep 2019 Apr 6;7(4):749-752. Epub 2019 Mar 6.

Department of Pathobiology Ontario Veterinary College Guelph Ontario Canada.

These two cases highlight some of the many challenges encountered when handling dog bite and rabies exposure. They also provide examples of the many barriers, and while highlighting only two individuals, they are likely representative of large numbers of the over 59 000 people that die every year from this preventable disease. Read More

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http://dx.doi.org/10.1002/ccr3.1972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452487PMC

Ecology and epidemiology of rabies in humans, domestic animals and wildlife in Namibia, 2011-2017.

PLoS Negl Trop Dis 2019 Apr 16;13(4):e0007355. Epub 2019 Apr 16.

Directorate of Veterinary Services (DVS), Ministry of Agriculture Water and Forestry, Windhoek, Namibia.

Rabies is a fatal zoonotic disease that causes a heavy burden on societies. Namibia, a country in southern Africa, is aiming at controlling the disease in its main reservoir, the domestic dog. To facilitate the implementation comprehensive information on the ecology and epidemiology of the disease and surveillance is of utmost importance. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007355DOI Listing

Size, spatial and household distribution, and rabies vaccination coverage of the Brazilian owned-dog population Brazilian owned-dog population.

Transbound Emerg Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva 87, Cidade Universitária, São Paulo, SP, CEP: 05508-270, Brazil.

Dog rabies and human rabies transmitted by dogs can be prevented through adequate dog vaccination coverage. For surveillance purposes, this coverage must be calculated using accurate population size estimates to avoid misleading conclusions. We used data from a Brazilian national survey comprising 64,348 households, to calculate point estimates and confidence intervals of the size, household density, and rabies vaccination coverage of the owned-dog population in Brazilian federative units. Read More

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http://dx.doi.org/10.1111/tbed.13204DOI Listing

[Risk of zoonoses by animal bites and scratches].

Rev Prat 2019 Mar;69(3):320-323

Ancien professeur en pathologie infectieuse, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes-Atlantique, Oniris, Nantes, France.

Risk of zoonoses by animal bites and scratches. The objectives of this study are to identify zoonosis risks related to animal bites and scratches in France. Pet-transmitted zoonoses, as pasteurellosis, cat scratches disease and various specific bacterial infections, are predominant, resulting usually in localized infections or, sometimes, in serious systemic infections (as those caused by Capnocytophaga canimorsus) in immunocompromised patients. Read More

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March 2019
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Oral vaccines could be key to mass rabies dog vaccination.

Authors:

Vet Rec 2019 Apr;184(15):464-465

reports on new work that looks into methods of vaccinating dogs in Goa. Read More

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http://dx.doi.org/10.1136/vr.l1744DOI Listing

Human rabies post exposure prophylaxis at the Pasteur Institute of Dakar, Senegal: trends and risk factors.

BMC Infect Dis 2019 Apr 11;19(1):321. Epub 2019 Apr 11.

Pasteur Institute of Dakar, Epidemiology unit, Dakar, Senegal.

Background: Rabies remains a major public health problem in developing countries. Most fatal rabies cases, especially in children, result from dog bites and occur in low-income countries, such as those in Sub-Saharan Africa. Rabies can be controlled through mass dog vaccination and human deaths prevented through timely and appropriate post-exposure prophylaxis (PEP). Read More

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http://dx.doi.org/10.1186/s12879-019-3928-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460513PMC
April 2019
1 Read

Management and treatment of animal bites.

JAAPA 2018 Apr;31(4):27-31

John B. Hurt is an assistant professor and director of clinical education in the PA program at Samford University in Birmingham, Ala. Kristopher R. Maday is program director of the PA program at the University of Tennessee Health Science Center in Memphis. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Animal bites account for 1% of ED visits and more than $50 million in healthcare costs annually in the United States. Managing bite wounds can be challenging and providers must consider the patient's tetanus status, species of animal inflicting the bite, and infection risk. This article describes treatment and care of bites and when rabies prophylaxis is indicated. Read More

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http://dx.doi.org/10.1097/01.JAA.0000531049.59137.cdDOI Listing
April 2018
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A viral metagenomic survey identifies known and novel mammalian viruses in bats from Saudi Arabia.

PLoS One 2019 10;14(4):e0214227. Epub 2019 Apr 10.

Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America.

Bats are implicated as natural reservoirs for a wide range of zoonotic viruses including SARS and MERS coronaviruses, Ebola, Marburg, Nipah, Hendra, Rabies and other lyssaviruses. Accordingly, many One Health surveillance and viral discovery programs have focused on bats. In this report we present viral metagenomic data from bats collected in the Kingdom of Saudi Arabia [KSA]. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214227PLOS
April 2019
1 Read
3.234 Impact Factor

[Animal and human bites : what to do and what to know ?]

Rev Med Suisse 2019 Apr;15(646):780-785

Service des maladies infectieuses, HUG, 1211 Genève 14.

Animal and human bites are a common cause of admission to the emergency room and the infections are common, although they are often trivialized. Complications can range from simple cellulitis to septic shock especially in asplenic patients with Capnoyctophaga canimorsus infection. Other less common infections are possible such as rat-bite fever, leptospirosis, tularemia, and evaluation of post-exposure prophylaxis (anti-tetanus, anti-rabies, HIV, HBV) is essential. Read More

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April 2019
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Pten loss results in inappropriate excitatory connectivity.

Mol Psychiatry 2019 Apr 9. Epub 2019 Apr 9.

Department of Molecular and Systems Biology, Dartmouth Geisel School of Medicine, Hanover, NH, 03755, USA.

Pten mutations are associated with autism spectrum disorder. Pten loss of function in neurons increases excitatory synaptic connectivity, contributing to an imbalance between excitation and inhibition. We aimed to determine whether Pten loss results in aberrant connectivity in neural circuits. Read More

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http://dx.doi.org/10.1038/s41380-019-0412-6DOI Listing

Dog Transport and Infectious Disease Risk: An International Perspective.

Authors:
Katherine Polak

Vet Clin North Am Small Anim Pract 2019 Apr 6. Epub 2019 Apr 6.

FOUR PAWS International, 89 AIA Capital Center, 20th Floor, Room 2081/2083, Ratchadapisek Road, Kwaeng Dindaeng, Khet Dindaeng, Bangkok 10400 Thailand. Electronic address:

International canine transport programs are gaining popularity, moving dogs from limited-resourced facilities to those with an increased capacity to provide better animal care and outcomes. For many animals, transport is a lifesaving measure, but is not without risk. The long-distance movement of dogs can facilitate disease spread, particularly when exporting agencies are located in rabies-endemic areas and lack staff trained in infectious disease control. Read More

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http://dx.doi.org/10.1016/j.cvsm.2019.02.003DOI Listing

Rabies: Current Preventive Strategies.

Authors:
Susan M Moore

Vet Clin North Am Small Anim Pract 2019 Apr 5. Epub 2019 Apr 5.

Veterinary Diagnostic Laboratory, Kansas State University, Manhattan, KS 66502, USA. Electronic address:

Desensitization to rabies is a result of successfully eliminating canine rabies in the United States, which occurred in 2007; however, the need for mandatory rabies vaccination in pets remains. Rabies cases are rare in comparison with other vaccine-preventable diseases in companion animals; however, because it is a zoonotic disease with the highest case fatality rate of any infectious disease demands the establishment of strict laws for disease prevention. Preventive strategies include addressing current concerns in consideration of disease surveillance, appropriate vaccination recommendations, and local regulations protecting public health. Read More

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http://dx.doi.org/10.1016/j.cvsm.2019.02.014DOI Listing

A social justice perspective on access to human rabies vaccines.

Vaccine 2019 Mar 27. Epub 2019 Mar 27.

Institute of Health & Wellbeing, College of Social Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address:

Rabies kills tens of thousands of people every year despite being entirely vaccine preventable. Key global health actors have launched a country-driven plan to achieve zero human deaths from dog-mediated rabies by 2030 worldwide. This partnership has recently been strengthened by Gavi, the Vaccine Alliance's decision to invest in human rabies vaccines for post-exposure prophylaxis (PEP). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193015
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http://dx.doi.org/10.1016/j.vaccine.2019.01.065DOI Listing
March 2019
2 Reads

N-Methyl-D-Aspartate Encephalitis our Experience with Diagnostic Dilemmas, Clinical Features, and Outcome.

J Pediatr Neurosci 2018 Oct-Dec;13(4):423-428

Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Introduction: A neuropsychiatric syndrome characterized by a wide spectrum of clinical manifestations. It is seen in patients with antibodies against NR1-NR2 heteromers of the NMDA receptor. As the spectrum is mainly psychiatric most patients are treated as psychiatric disease resulting in huge diagnostic delay. Read More

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http://dx.doi.org/10.4103/JPN.JPN_96_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413609PMC
April 2019
1 Read

Serological profiling of rabies antibodies by enzyme-linked immunosorbent assay and its comparative analysis with rapid fluorescent focus inhibition test in mouse model.

Vet World 2019 Jan 23;12(1):126-130. Epub 2019 Jan 23.

Recombinant DNA Laboratory, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India.

Aim: In this study, we have used enzyme-linked immunosorbent assay (ELISA) as an alternative test to replace the cumbersome rapid fluorescent focus inhibition test (RFFIT) to ascertain the immune status of immunized mice against rabies virus.

Materials And Methods: Rabies is a devastating disease worldwide caused by rabies virus. Proper usage of pre- or post-exposure rabies vaccine can prevent the disease transmission. Read More

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http://dx.doi.org/10.14202/vetworld.2019.126-130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431817PMC
January 2019
1 Read

Exosome-Mediated Delivery of Inducible miR-423-5p Enhances Resistance of MRC-5 Cells to Rabies Virus Infection.

Int J Mol Sci 2019 Mar 27;20(7). Epub 2019 Mar 27.

National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, China.

The human diploid cell line Medical Research Council -5 (MRC-5) is commonly utilized for vaccine development. Although a rabies vaccine developed in cultured MRC-5 cells exists, the poor susceptibility of MRC-5 cells to the rabies virus (RABV) infection limits the potential yield of this vaccine. The underlying mechanism of MRC-5 cell resistance to RABV infection remains unknown. Read More

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http://dx.doi.org/10.3390/ijms20071537DOI Listing
March 2019
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A community-based knowledge, attitude, and practice survey on rabies among cattle owners in selected areas of Bhutan.

PLoS Negl Trop Dis 2019 04 1;13(4):e0007305. Epub 2019 Apr 1.

Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Alberta, Canada.

Rabies remains a disease of significant zoonotic and economic concern in rabies endemic areas of Bhutan. Rabies outbreaks in livestock threaten the livelihoods of subsistence farming communities and pose a potential public health threat. As a part of identifying approaches to prevent rabies in cattle, a Knowledge, Attitude, and Practice (KAP) survey was conducted among cattle owners in selected rural areas of the southern rabies high-risk zone and low-risk zone in eastern Bhutan. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007305DOI Listing
April 2019
4 Reads

Revised recommendations for rabies pre-exposure prophylaxis in travellers: avoid bumpy roads, select the highway!

J Travel Med 2019 Mar 29. Epub 2019 Mar 29.

Epidemiology, Biostatistics and Prevention Institute, World Health Organization Collaborating Centre for Traveller's Health, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1093/jtm/taz021DOI Listing

Duclaux, Chamberland, Roux, Grancher, and Metchnikoff: the five musketeers of Louis Pasteur.

Genes Immun 2019 Mar 29. Epub 2019 Mar 29.

Centre de ressources en information scientifique, Institut Pasteur, Paris, France.

The Institut Pasteur was created, thanks to worldwide generosity with the aim to welcome and treat rabies patients, to provide a place for scientific research and to offer new teaching programs in microbiology. Louis Pasteur invited his main collaborators, who had accompanied him during his previous investigations at École Normale Supérieure, to join him in his new institute. They contributed to the principle discoveries of Pasteur, such as the fight against spontaneous generation, the identification of the ferments of putrefaction, the fight against the silk worm disease, the research on wine and beer, and the set-up of the first vaccines against avian cholera, anthrax, swine erysipelas, and rabies. Read More

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http://dx.doi.org/10.1038/s41435-019-0064-1DOI Listing
March 2019
1 Read

Avoiding preventable deaths: The scourge of counterfeit rabies vaccines.

Vaccine 2019 Apr 25;37(17):2285-2287. Epub 2019 Mar 25.

Animal and Plant Health Agency, WHO Collaborating Centre for Characterisation of Rabies and Rabies-Related Viruses, OIE Reference Laboratory for Rabies, Weybridge, UK; Institute of Infection & Global Health, University of Liverpool, Liverpool, UK; St. George's Hospital Medical School, Institute for Infection and Immunity, University of London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2019.03.037DOI Listing
April 2019
2 Reads

Knowledge, attitudes and practices towards rabies prevention among residents of Abuja municipal area council, Federal Capital Territory, Nigeria.

Pan Afr Med J 2018 10;31:21. Epub 2018 Sep 10.

Nigeria Field Epidemiology and Laboratory Training Program, Abuja, Nigeria.

Introduction: Rabies is a fatal neglected zoonosis killing 55,000 people worldwide annually. It is endemic in Nigeria with 10,000 people exposed annually through dog-bites. To inform adequate intervention due to the rise in reported dog-bite cases, we assessed knowledge, attitudes and practices (KAP). Read More

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http://dx.doi.org/10.11604/pamj.2018.31.21.15120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430844PMC
April 2019
1 Read

Identification of CP77 as the third orthopoxvirus SAMD9 and SAMD9L inhibitor with a unique specificity for a rodent SAMD9L.

J Virol 2019 Mar 27. Epub 2019 Mar 27.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA

Orthopoxviruses (OPXVs) have a broad host range in mammalian cells, but Chinese hamster ovary (CHO) cells are non-permissive for vaccinia virus (VACV). Here, we revealed a species-specific difference in host restriction factor SAMD9L as the cause for the restriction and identified orthopoxvirus CP77 as a unique inhibitor capable of antagonizing Chinese hamster SAMD9L (chSAMD9L). Two known VACV inhibitors of SAMD9 and SAMD9L (SAMD9&L);, K1 and C7, can bind human and mouse SAMD9&L;, but neither can bind chSAMD9L. Read More

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http://dx.doi.org/10.1128/JVI.00225-19DOI Listing
March 2019
1 Read

A cross-sectional study of knowledge regarding rabies among attendees of anti-rabies clinic of a teaching hospital, Jaipur.

J Family Med Prim Care 2019 Jan;8(1):194-198

Department of Cardiothoracic and Vascular Surgery, S.M.S. Medical College, Jaipur, Rajasthan, India.

Background: Being a fatal and 100% preventable disease, all efforts must be made by the health system to prevent even a single case of rabies. By assessing the knowledge of people regarding rabies prevention, we can make plans and policies for its prevention. The aim of this study was to assess the knowledge regarding rabies among attendees of anti-rabies clinic of a teaching hospital, Jaipur. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_205_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396603PMC
January 2019
1 Read

Cost Savings of Using Updated Thai Red Cross Intradermal Regimen in a High-Throughput Anti-Rabies Clinic in New Delhi, India.

Trop Med Infect Dis 2019 Mar 22;4(1). Epub 2019 Mar 22.

Department of Orthopedics, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi 110001, India.

Replacement of the Essen intramuscular (EIM) by the updated Thai Red Cross intradermal (UTRCID) regimen for rabies post-exposure prophylaxis (PEP), in high-throughput hospitals of India, has been advocated since 2006 thanks to its cost-effectiveness. However, several anti-rabies clinics in India and other parts of the world have not initiated this switchover of regimens because of the paucity of financial literature, generated in realistic settings, regarding the same. We calculated the procurement costs of various items required for providing rabies vaccinations via the EIM regimen and UTRCID regimen, on an annual basis, a year before and after the switchover. Read More

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https://www.mdpi.com/2414-6366/4/1/50
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http://dx.doi.org/10.3390/tropicalmed4010050DOI Listing
March 2019
5 Reads

Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers.

Front Immunol 2019 8;10:429. Epub 2019 Mar 8.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.

Rabies virus (RABV) causes fatal encephalitis in mammals and poses a public health threat in many parts of the world. Vaccination remains the most effective means for prevention and control of rabies. Studies focusing on the mechanism of RABV immunogenicity are necessary for improvement of rabies vaccines. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418000PMC
March 2019
3 Reads

Purification of IgG against ribonucleoprotein by a homemade immunoaffinity chromatography column for rabies diagnosis.

J Immunol Methods 2019 Mar 20. Epub 2019 Mar 20.

Instituto Pasteur, São Paulo, Brazil. Electronic address:

Polyclonal or monoclonal antibodies against rabies virus ribonucleoprotein (RNP) conjugated to fluorescein isothiocyanate (FITC) have been employed for Rabies virus (RABV) antigen detection by the direct fluorescent antibody test (DFA). To date, these biomolecules have been purified by traditional methods such as precipitation by ammonium sulfate or ion exchange chromatography followed by ammonium sulfate precipitation, which allows only for partial detection of the protein of interest. In this study, we aimed to purify anti-RNP polyclonal horse IgG antibodies by cation-exchange chromatography in combination with a homemade immunoaffinity chromatography on RNP immobilized (RNP-IAC). Read More

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http://dx.doi.org/10.1016/j.jim.2019.03.007DOI Listing
March 2019
2.005 Impact Factor

Recombinant Viral Vectors as Neuroscience Tools.

Curr Protoc Neurosci 2019 04 22;87(1):e67. Epub 2019 Mar 22.

Viral Vector Core, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, North Carolina.

Recombinant viruses are highly efficient vehicles for in vivo gene delivery. Viral vectors expand the neurobiology toolbox to include direct and rapid anterograde, retrograde, and trans-synaptic delivery of tracers, sensors, and actuators to the mammalian brain. Each viral type offers unique advantages and limitations. Read More

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http://dx.doi.org/10.1002/cpns.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438761PMC
April 2019
4 Reads

A new recombinant rabies virus expressing a green fluorescent protein: A novel and fast approach to quantify virus neutralizing antibodies.

Biologicals 2019 Mar 18. Epub 2019 Mar 18.

Laboratory of Method Development, Division of Viral Products, Center for Biologics Evaluation, Food and Drug Administration, Silver Spring, MD, USA. Electronic address:

The Rapid Fluorescent Focus Inhibition Test (RFFIT) is a standard assay used to detect and assess the titers of rabies virus neutralizing antibodies (RVNA) in blood sera. To simplify the multistep RFFIT procedure by eliminating the immunostaining step, we generated a new recombinant RV expressing a green fluorescent protein (rRV-GFP) and assess its suitability for quantifying RVNA. We rescued the rRV-GFP virus from plasmid DNA carrying a full-length genome of the CVS-N2c strain of RV in which the eGFP gene was inserted between the glycoprotein and RNA-polymerase genes. Read More

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http://dx.doi.org/10.1016/j.biologicals.2019.03.002DOI Listing
March 2019
1 Read

[Сases of human convalescence from rabies and lifetime diagnostics of lyssavirus encephalitis.]

Vopr Virusol 2019 ;64(1):42-48

Federal Center for Animal Health, Vladimir, 600901, Russian Federation.

Notwithstanding the availability of effective vaccines, 40 - 60 thousand rabies cases in humans are reported every year. Almost always the disease is fatal because therapeutic treatment of lyssavirus encephalitis has not been developed. Since 1970 the number of reports on rare cases of convalescence including those using experimental treatment protocols has been gradually increasing 20 cases of convalescence, "partial" convalescence or long-term survival of humans (1970-2015) were selected as they were complaint with laboratory criteria of active lyssavirus infection. Read More

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http://dx.doi.org/10.18821/0507-4088-2019-64-1-42-48DOI Listing
January 2019
2 Reads

A Scoping Review of Dingo and Wild-Living Dog Ecology and Biology in Australia to Inform Parameterisation for Disease Spread Modelling.

Front Vet Sci 2019 5;6:47. Epub 2019 Mar 5.

Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camden, NSW, Australia.

Dingoes and wild-living dogs in Australia, which include feral domestic dogs and dingo-dog hybrids, play a role as reservoirs of disease. In the case of an exotic disease incursion-such as rabies-these reservoirs could be a threat to the health of humans, domestic animals and other wildlife in Australia. Disease spread models are needed to explore this impact and develop mitigation strategies for responding to an incursion. Read More

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http://dx.doi.org/10.3389/fvets.2019.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411765PMC

Intradermal post-exposure rabies vaccination with purified Vero cell rabies vaccine: Comparison of a one-week, 4-site regimen versus updated Thai Red Cross regimen in a randomized non-inferiority trial in the Philippines.

Vaccine 2019 Apr 16;37(16):2268-2277. Epub 2019 Mar 16.

Sanofi Pasteur, 14 Espace Henry Vallée, 69007 Lyon, France. Electronic address:

Background: Rabies post-exposure prophylaxis (PEP) via intradermal (ID) administration is standard practice in Asia. Accumulating evidence suggests that PEP shortened to 3 visits in one week does not adversely affect seroconversion rates or immune memory.

Objective: To determine whether the seroconversion rate at Day14 with a 1-week, 4-site (4-4-4-0-0) ID vaccination regimen with or without rabies immunoglobulin (RIG) was non-inferior to the updated Thai Red Cross (TRC) 28-day, 2-site (2-2-2-0-2) ID regimen with RIG during rabies PEP. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.02.083DOI Listing
April 2019
7 Reads

Frugivorous bats in the Colombian Caribbean region are reservoirs of the rabies virus.

Ann Clin Microbiol Antimicrob 2019 Mar 19;18(1):11. Epub 2019 Mar 19.

Producción Animal Tropical Facultad de Medicina Veterinaria y Zootecnia, Universidad de Córdoba, Monteria, Colombia.

Background: Bats are an important ecological group within ecosystems. The rabies virus is a Lyssavirus, and haematophagous bats are the principal reservoir; however, the virus has also been detected in non-haematophagous bats. The objective was to determine the rabies virus in non-haematophagous bats in the Colombian Caribbean region. Read More

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http://dx.doi.org/10.1186/s12941-019-0308-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423830PMC
March 2019
1 Read

A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.

Nat Neurosci 2019 Apr 18;22(4):657-668. Epub 2019 Mar 18.

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

The local and long-range connectivity of cortical neurons are considered instrumental to the functional repertoire of the cortical region in which they reside. In cortical networks, distinct cell types build local circuit structures enabling computational operations. Computations in the medial prefrontal cortex (mPFC) are thought to be central to cognitive operation, including decision-making and memory. Read More

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http://www.nature.com/articles/s41593-019-0354-y
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http://dx.doi.org/10.1038/s41593-019-0354-yDOI Listing
April 2019
13 Reads

Production of Viral Constructs for Neuroanatomy, Calcium Imaging, and Optogenetics.

Curr Protoc Neurosci 2019 04 18;87(1):e66. Epub 2019 Mar 18.

Viral Vector Core, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, North Carolina.

Advances in design and use of light-sensitive and light-emitting sensors have facilitated observation, measurement, and control of neuronal activities. Viruses are effective vectors for delivery of these valuable research tools to mammalian brains. Recombinant viruses are optimized to mediate regulatable, long-term, and cell-specific gene expression. Read More

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http://dx.doi.org/10.1002/cpns.66DOI Listing
April 2019
1 Read

Feline herpesvirus vectored-rabies vaccine in cats: A dual protection.

Vaccine 2019 Apr 14;37(16):2224-2231. Epub 2019 Mar 14.

Military Veterinary Research Institute, Academy of Military Medical Sciences, Changchun, PR China. Electronic address:

In China, cats cause about 5% of human rabies cases. Rabies control in cats plays a role in achieving the ultimate goal of elimination of dog rabies-mediated human deaths. However, there is no cat-specific rabies vaccine in China yet. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.008DOI Listing
April 2019
3 Reads

Canine Rabies in the Brazil-Bolivia Border Region from 2006 to 2014.

Ann Glob Health 2019 Mar 4;85(1). Epub 2019 Mar 4.

State Agency of Animal and Plant Health Protection of Mato Grosso do Sul, Animal Diseases Diagnostic Laboratory, Campo Grande, Mato Grosso do Sul, BR.

Background: After 2006 the cross-border region between the state of Mato Grosso do Sul (Brazil) and the Germán Busch Province (Bolivia) became risk areas for canine rabies antigenic variant 1, previously unknown in the Brazilian territory.

Objectives: To perform a descriptive analysis of canine rabies from 2006 to 2014, analyzing the database of the official rabies diagnostic laboratory of the State Agency of Animal and Plant Health Protection of Mato Grosso do Sul.

Methods: A descriptive analysis of canine rabies from 2006 to 2014 was performed using the database of the official rabies diagnostic laboratory of the State Agency of Animal and Plant Health Protection of Mato Grosso do Sul. Read More

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http://dx.doi.org/10.5334/aogh.2334DOI Listing
March 2019
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Comparative study of rabies antibody titers of dogs vaccinated in Finland and imported street dogs vaccinated abroad.

Acta Vet Scand 2019 Mar 14;61(1):15. Epub 2019 Mar 14.

Virology Unit, Finnish Food Authority, Mustialankatu 3, 00790, Helsinki, Finland.

Seventy-two canine serum samples were analyzed for post-vaccination serum titers of rabies antibodies. The samples were divided into two groups: Group 1 dogs (n = 36) were imported dogs from the Russian Federation (n = 31) or Romania (n = 5), with a mean serum antibody titer value of 1.54 IU/mL. Read More

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http://dx.doi.org/10.1186/s13028-019-0450-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419415PMC
March 2019
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Using roaming behaviours of dogs to estimate contact rates: the predicted effect on rabies spread.

Epidemiol Infect 2019 Jan;147:e135

Veterinary Public Health Institute, University of Bern,Liebefeld,Switzerland.

Domestic dogs display complex roaming behaviours, which need to be captured to more realistically model the spread of rabies. We have previously shown that roaming behaviours of domestic dogs can be categorised as stay-at-home, roamer and explorer in the Northern Peninsular Area (NPA), Queensland, Australia. These roaming behaviours are likely to cause heterogeneous contact rates that influence the speed or pattern of rabies spread in a dog population. Read More

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http://dx.doi.org/10.1017/S0950268819000189DOI Listing
January 2019

Molecular detection of rabies virus strain with N-gene that clustered with China lineage 2 co-circulating with Africa lineages in Monrovia, Liberia: first reported case in Africa.

Epidemiol Infect 2019 Jan;147:e85

National Veterinary Research Institute (N.V.R.I.),Vom, Plateau State,Nigeria.

Despite a long history of dog-transmitted human rabies outbreaks in Liberia, West Africa, no reports exist of molecular characterisation of the causative lyssaviruses. This study investigated Rabies lyssavirus (RABV) strains isolated at the dog-human interface in Monrovia, Liberia 2016 and 2017, by reverse transcription polymerase chain reaction, using primers specific for the nucleoprotein (N) gene. Out of 20 specimens (19 dog brain samples and one human saliva) tested as suspected rabies cases, three (15%) were positive. Read More

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http://dx.doi.org/10.1017/S0950268818003333DOI Listing
January 2019

Spatiotemporal distribution of a non-haematophagous bat community and rabies virus circulation: a proposal for urban rabies surveillance in Brazil.

Epidemiol Infect 2019 Jan;147:e130

Unidade de Vigilância de Zoonoses de Campinas, Prefeitura Municipal de Campinas,Campinas,Brazil.

In Brazil, rabies surveillance is based on monitoring domestic and wild animals, although the most prevalent lineage of the rabies virus (RABV) currently diagnosed in Brazil is associated with bats, particularly non-haematophagous bats. Disease control is based on the mass vaccination of dogs and cats. We used data collected by the passive surveillance system of the city of Campinas from 2011 to 2015, to describe the temporal and geographic distributions of the bat specimens and RABV and discuss the current rabies surveillance with the advent of the declaration of canine and feline rabies-free areas in Brazil. Read More

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http://dx.doi.org/10.1017/S0950268818003229DOI Listing
January 2019

Genetic and spatial characterization of the red fox (Vulpes vulpes) population in the area stretching between the Eastern and Dinaric Alps and its relationship with rabies and canine distemper dynamics.

PLoS One 2019 12;14(3):e0213515. Epub 2019 Mar 12.

Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Legnaro, Italy.

Information on the population dynamics of a reservoir species have been increasingly adopted to understand and eventually predict the dispersal patterns of infectious diseases throughout an area. Although potentially relevant, to date there are no studies which have investigated the genetic structure of the red fox population in relation to infectious disease dynamics. Therefore, we genetically and spatially characterised the red fox population in the area stretching between the Eastern and Dinaric Alps, which has been affected by both distemper and rabies at different time intervals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213515PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413928PMC
March 2019
1 Read