14,923 results match your criteria Rabies
PLoS Pathog 2018 Dec 6;14(12):e1007392. Epub 2018 Dec 6.
KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Evolutionary and Computational Virology, Leuven, Belgium.
Despite ongoing efforts to control transmission, rabies prevention remains a challenge in many developing countries, especially in rural areas of China where re-emerging rabies is under-reported due to a lack of sustained animal surveillance. By taking advantage of detailed genomic and epidemiological data for the re-emerging rabies outbreak in Yunnan Province, China, collected between 1999 and 2015, we reconstruct the demographic and dispersal history of domestic dog rabies virus (RABV) as well as the dynamics of dog-to-dog and dog-to-human transmission. Phylogeographic analyses reveal a lower diffusion coefficient than previously estimated for dog RABV dissemination in northern Africa. Read More
Public Health Rep 2018 Dec 3:33354918810776. Epub 2018 Dec 3.
1 Rabies Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, NY, USA.
Objectives:: Each year, rabies virus infection results in the death of more than 50 000 persons worldwide. In the United States, the Centers for Disease Control and Prevention (CDC) reported 23 human rabies cases from May 1, 2008, through October 1, 2017. Although rabies testing in the United States is highly reliable, some specimens submitted to rabies laboratories do not have adequate tissues or may be substantially decomposed. Read More
Vector Borne Zoonotic Dis 2018 Dec 1. Epub 2018 Dec 1.
Center for Zoonotic and Vectorborne Diseases, Maryland Department of Health, Baltimore, Maryland.
Rabies is a zoonotic disease that poses a serious public health risk. To facilitate pet owner compliance with statewide mandatory animal rabies immunization requirements, Maryland statute requires Maryland's local health departments to conduct low-cost animal rabies vaccination clinics at least twice per year. We describe the outputs of these public low-cost clinics by documenting the number of animals vaccinated, number of clinics held annually, and cost per vaccine to pet owners for the years 2015-2016. Read More
J Clin Invest 2018 Dec 3. Epub 2018 Dec 3.
Department of Neurosciences, Cleveland Clinic, Cleveland, Ohio, USA.
We investigated how pathological changes in newborn hippocampal dentate granule cells (DGCs) lead to epilepsy. Using a rabies virus-mediated retrograde tracing system and a designer receptors exclusively activated by designer drugs (DREADD) chemogenetic method, we demonstrated that newborn hippocampal DGCs are required for the formation of epileptic neural circuits and the induction of spontaneous recurrent seizures (SRS). A rabies virus-mediated mapping study revealed that aberrant circuit integration of hippocampal newborn DGCs formed excessive de novo excitatory connections as well as recurrent excitatory loops, allowing the hippocampus to produce, amplify, and propagate excessive recurrent excitatory signals. Read More
J Wildl Dis 2018 Dec 3. Epub 2018 Dec 3.
3 US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Rabies Management Program, 59 Chenell Drive, Concord, New Hampshire 03301, USA.
From 2014 to 2016, we examined the effect of distributing oral rabies vaccine baits at high density (150 baits/km) in an area of Virginia that was naïve to oral rabies vaccination prior to the study. We also compared the effect of baiting at high density in a naïve area to baiting at standard density (75 baits/km) in an area that had been baited annually for 12 yr. Our results suggested that rabies virus seroconversion in raccoons ( Procyon lotor) gradually increased each year under the high-density bait treatment. Read More
J Educ Health Promot 2018 29;7:129. Epub 2018 Oct 29.
Department of Community Medicine, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Introduction: Immunization against vaccine-preventable diseases in adults is the need of the hour. The student nurses by virtue of training are the frontline health workers dealing with patient care. They are exposed to maximum risk of contracting the diseases. Read More
Vaccine 2018 Nov 29. Epub 2018 Nov 29.
The World Health Organization, Geneva, Switzerland.
Despite successful control in many parts of the world, rabies virus continues to result in tens of thousands of deaths each year. Death from rabies can be prevented by timely and appropriate post exposure prophylaxis including wound cleaning and administration of vaccine and rabies immunoglobulin. Currently, rabies immunoglobulin is derived from the blood plasma of horses or humans and has several limitations relating to supply, cost and quality. Read More
Vet Microbiol 2018 Nov 16. Epub 2018 Nov 16.
School of Animal Science and Technology, Changchun University of Science and Technology, Jilin province, China. Electronic address:
Epidemiol Serv Saude 2018 Nov 29;27(4):e2017547. Epub 2018 Nov 29.
Universidade Federal do Ceará, Departamento de Saúde Comunitária, Fortaleza, CE, Brasil.
Objective: to analyze the prevalence of inadequate human anti-rabies post-exposure prophylaxis in patients attacked by animals in the state of Ceará, Brazil, 2007-2015.
Methods: this was a study of the prevalence of inadequate prophylaxis procedures, using data on reported cases of accidents involving animals potentially capable of transmitting rabies registered on the Notifiable Diseases Information System (SINAN) from January 2007 to December 2015.
Results: of the 231,694 reported cases, 95. Read More
PLoS One 2018 5;13(12):e0207604. Epub 2018 Dec 5.
Institute of Virology and Immunology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
The first records of smallpox and rabies date back thousands of years and foot-and-mouth disease in cattle was described in the 16th century. These diseases stood out by their distinct signs, dramatic way of transmission from rabid dogs to humans, and sudden appearance in cattle herds. By contrast, infectious diseases that show variable signs and affect few individuals were identified only much later. Read More
Infect Dis Poverty 2018 Dec 5;7(1):117. Epub 2018 Dec 5.
Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Background: The injection of rabies immune globulin (RIG) is of the utmost importance in the management of category III exposures to rabies-suspect animals. Because of the high cost and limited availability of existing RIG, one possible replacement for RIG is monoclonal antibodies (MAbs) against the rabies virus (RABV). Consequently, it is necessary to determine the neutralizing activity of the MAbs against rabies viruses, especially street rabies virus. Read More
Viruses 2018 12 3;10(12). Epub 2018 Dec 3.
INSERM UMR-S 1124, Université Paris Descartes, 75006 Paris, France.
Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (SUMO1, 2, and 3). Infection by rhabdoviruses triggers cellular responses through the activation of pattern recognition receptors, which leads to the production and secretion of interferon. Read More
Epidemiol Infect 2018 Dec 4:1-6. Epub 2018 Dec 4.
Department of Epidemiology and Health Statistics,School of Public Health, Southeast University,Nanjing (210009),China.
Rabies is one of the major public health problems in China, and the mortality rate of rabies remains the highest among all notifiable infectious diseases. A meta-analysis was conducted to investigate the post-exposure prophylaxis (PEP) vaccination rate and risk factors for human rabies in mainland China. The PubMed, Web of Science, Chinese National Knowledge Infrastructure, Chinese Science and Technology Periodical and Wanfang databases were searched for articles on rabies vaccination status (published between 2007 and 2017). Read More
Epidemiol Infect 2018 Dec 4:1-6. Epub 2018 Dec 4.
FAO and National Reference Centre for Rabies, Istituto Zooprofilattico Sperimentale delle Venezie,Viale dell'Università 10, Legnaro (PD),Italy.
The wide geographical distribution and genetic diversity of bat-associated lyssaviruses (LYSVs) across Europe suggest that similar viruses may also be harboured in Italian insectivorous bats. Indeed, bats were first included within the passive national surveillance programme for rabies in wildlife in the 1980s, while active surveillance has been performed since 2008. The active surveillance strategies implemented allowed us to detect neutralizing antibodies directed towards European bat 1 lyssavirus in six out of the nine maternity colonies object of the study across the whole country. Read More
Vaccine 2018 Nov 30. Epub 2018 Nov 30.
Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
In Madagascar, dog-mediated rabies has been endemic for over a century, however there is little data on its incidence or impact. We collected data over a 16-month period on provisioning of post-exposure prophylaxis (PEP) at a focal clinic in the Moramanga District and determined the rabies status of biting animals using clinical and laboratory diagnosis. We find that animal rabies cases are widespread, and clinic-based triage and investigation are effective ways to increase detection of rabies exposures and to rule out non-cases. Read More
J Theor Biol 2018 Nov 27;462:408-417. Epub 2018 Nov 27.
Swiss Tropical and Public Health Institue, Socinstrasse 57, Basel 4051, Switzerland; University of Basel, Petersplatz 1, Basel 4001, Switzerland.
Rabies transmission was interrupted for several months in N'Djamena, the capital city of Chad, after two mass vaccination campaigns of dogs. However, there was a resurgence in cases, which was not predicted by previous models of rabies transmission. We developed a deterministic metapopulation model with importation of latent dogs, calibrated to four years of weekly incidence data from passive surveillance, to investigate possible causes for the early resurgence. Read More
Lond Med Phys J 1815 Apr;33(194):293-297
Med Phys J 1814 Mar;31(181):231-235
Med Phys J 1810 Mar;23(133):223-225
South Audley Street.
Med Phys J 1808 Dec;20(118):531-533
No. 9, Giltspur Street, West Smithfield.
Med Phys J 1806 Nov;16(93):437-440
Surgeon of His Majesty's Customs.
Med Phys J 1804 Dec;12(70):512-513
Physician to the Manchester Infirmary.
Med Phys J 1804 Nov;12(69):385-391
Physician to the Manchester Infirmary.
Med Phys J 1805 Feb;13(72):155-163
Physician to the Manchester Infirmary, Lunatic Hospital, &c.
Front Neural Circuits 2018 13;12:99. Epub 2018 Nov 13.
University of Chinese Academy of Sciences (UCAS), Beijing, China.
The mammalian basal forebrain (BF), a heterogenous structure providing the primary cholinergic inputs to cortical and limbic structures, plays a crucial role in various physiological processes such as learning/memory and attention. Despite the involvement of the BF cholinergic neurons (BFCNs) in olfaction related memory has been reported, the underlying neural circuits remain poorly understood. Here, we combined viral trans-synaptic tracing systems and ChAT-cre transgenic mice to systematically reveal the relationship between the olfactory system and the different subsets of BFCNs. Read More
Health Secur 2018 ;16(S1):S44-S53
Pia D. M. MacDonald, PhD, CPH, is a Senior Epidemiologist, Biostatistics and Epidemiology, RTI International, Durham, North Carolina.
High-functioning communicable disease surveillance systems are critical for public health preparedness. Countries that cannot quickly detect and contain diseases are a risk to the global community. The ability of all countries to comply with the International Health Regulations is paramount for global health security. Read More
BMC Infect Dis 2018 Nov 26;18(1):597. Epub 2018 Nov 26.
Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: Clinical Rabies is a widely distributed almost 100% fatal viral zoonotic disease. Most human rabies cases occur in developing countries, especially in Asia and Africa. It can be prevented by immunization, post exposure prophylaxis. Read More
J Travel Med 2018 Nov 22. Epub 2018 Nov 22.
Department of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Munich, Germany.
Background: Extensive global experience shows that rabies pre-exposure prophylaxis (PrEP) through vaccination is effective and well tolerated, yet many travellers opt not to be vaccinated when travelling to rabies-endemic countries. Previous research has identified several factors influencing the choices travellers make to reduce the risk of rabies, including cost, time constraint and perspective on the importance of vaccination. The objectives of this study were to assess travellers' awareness of rabies and advice-seeking attitudes and to evaluate travel clinics practices regarding rabies pre-travel advice. Read More
MSMR 2018 Nov;25(11):18-20
Lancet Infect Dis 2018 Nov 21. Epub 2018 Nov 21.
Background: Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply. Read More
Lancet Infect Dis 2018 Nov 21. Epub 2018 Nov 21.
Lyssavirus Dynamics and Host Adaptation, Institut Pasteur, Paris, France.
Vaccine 2018 Nov 21. Epub 2018 Nov 21.
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States. Electronic address:
The development of human rabies vaccines has evolved dramatically from the first crude nerve tissue vaccine produced then administered in the presence of Louis Pasteur in 1885. New cell culture technology has enabled highly potent and well-tolerated rabies vaccines to be produced that have reduced the volume and number of doses required to save human lives after exposure. However, these highly potent vaccines are still unaffordable to many patients living at risk of exposure on a daily basis. Read More
Sci Rep 2018 Nov 21;8(1):17188. Epub 2018 Nov 21.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in China from 2006 to 2012. Read More
J Neurophysiol 2018 Nov 21. Epub 2018 Nov 21.
Physics, UCSD, United States.
Rodents shift their nose from side to side when they actively explore and lateralize odors in the space. This motor action is driven by a pair of muscles, the deflector nasi. Here we study the premotor control of this motion. Read More
Zoonoses Public Health 2018 Nov 20. Epub 2018 Nov 20.
ANSES-Nancy Laboratory for Rabies and Wildlife, Malzéville, France.
Bat rabies cases are attributed in Europe to five different Lyssavirus species of 16 recognized Lyssavirus species causing rabies. One of the most genetically divergent Lyssavirus spp. has been detected in a dead Miniopterus schreibersii bat in France. Read More
Front Neuroanat 2018 16;12:84. Epub 2018 Oct 16.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
The nucleus accumbens (NAc) is clearly implicated in reward processing and drug addiction, as well as in numerous neurological and psychiatric disorders; nevertheless, the circuit mechanisms underlying the diverse functions of the NAc remain poorly understood. Here, we characterized the whole-brain and monosynaptic inputs to two main projection cell types - D1 dopamine receptor expressing medium spiny neurons (D1R-MSNs) and D2 dopamine receptor expressing medium spiny neurons (D2R-MSNs) - within the NAc core and NAc shell by rabies-mediated trans-synaptic tracing. We discovered that D1R-MSNs and D2R-MSNs in both NAc subregions receive similar inputs from diverse sources. Read More
Vet Immunol Immunopathol 2018 Nov 2;205:93-96. Epub 2018 Nov 2.
Boehringer Ingelheim Animal Health, Centre de Recherche de Saint-Vulbas, Parc Industriel de la Plaine de l'Ain, 805 Allée des Cyprès, 01150, Saint-Vulbas, France.
In many cicumstances, veterinarians are requiring to be able to administer rabies vaccine in dogs at the same time as vaccinating against canine distemper, adenovirus, parvovirus, parainfluenza virus and leptospirosis. The aim of this study was to assess the compatibility between a multivalent vaccine and a rabies vaccine when injected at two separate sites. Lack of interference was assessed by comparing serological response to viral components during one year following primary vaccination with vaccines administered alone or concomitantly. Read More
Hum Vaccin Immunother 2018 Nov 20. Epub 2018 Nov 20.
c Chengdu Kanghua Biological Products Co., Ltd ., Chengdu City , Sichuan , P.R. China.
The large-scale production of a human diploid cell (HDC) vaccine (HDCV) for rabies is limited by several technical challenges. Kanghua Biological Products Co., Ltd. Read More
Eur J Neurosci 2018 Nov 20. Epub 2018 Nov 20.
Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, NO-7489, Trondheim, Norway.
The posterior parietal cortex (PPC) is a multifaceted region of cortex, contributing to several cognitive processes including sensorimotor integration and spatial navigation. Although recent years have seen a considerable rise in the use of rodents, particularly mice, to investigate PPC and related networks, a coherent anatomical definition of PPC in the mouse is still lacking. To address this, we delineated the mouse PPC using cyto- and chemoarchitectural markers from Nissl-, parvalbumin- and muscarinic acetylcholine receptor M2-staining. Read More
Clin Case Rep 2018 Nov 23;6(11):2140-2143. Epub 2018 Sep 23.
Veterinary Teaching Hospital Ahmadu Bello University Zaria Nigeria.
This manuscript aims at creating awareness especially to livestock farmers and veterinarians/clinicians that rabies occurs in livestock species. Furthermore, clinicians should note that the viral load in dog bite cases by rabid dog can be reduced by vigorous washing and disinfection which may ultimately delay the clinical manifestation of rabies. Read More
Front Neurosci 2018 5;12:807. Epub 2018 Nov 5.
Department of Pharmacology, Department of Anatomy, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.
The suprachiasmatic nucleus (SCN) is the principal pacemaker driving the circadian rhythms of physiological behaviors. The SCN consists of distinct neurons expressing neuropeptides, including arginine vasopressin (AVP), vasoactive intestinal polypeptide (VIP), gastrin-releasing peptide (GRP), cholecystokinin (CCK), and so on. AVP, VIP, and GRP neurons receive light stimulation from the retina to synchronize endogenous circadian clocks with the solar day, whereas CCK neurons are not directly innervated by retinal ganglion cells and may be involved in the non-photic regulation of the circadian clock. Read More
Vaccine 2018 Nov 16. Epub 2018 Nov 16.
Inserm UMR 1153, Centre de Recherche Epidémiologie et Statistique Sorbonne Paris Cité, Hôpital Saint-Louis, Université Paris Diderot - Paris 7, Paris, France.
Rabies causes 60,000 deaths worldwide annually. Rabies post-exposure prophylaxis is highly effective but often geographically and financially beyond reach in endemic developing countries. We conducted a retrospective study on clinical outcome at ≥6 months in 3318 Cambodians who received intradermal Vero cell vaccine post-exposure prophylaxis after a bite by a rabid or sick-looking but untested dog in 2003-2014. Read More
J Vis Exp 2018 Nov 2(141). Epub 2018 Nov 2.
UNC Neuroscience Center; UNC/NC State Joint Department of Biomedical Engineering, UNC; Xona Microfluidics, LLC;
Microfabricated methods to compartmentalize neurons have become essential tools for many neuroscientists. This protocol describes the use of a commercially available pre-assembled plastic chip for compartmentalizing cultured primary rat hippocampal neurons. These plastic chips, contained within the footprint of a standard microscope slide, are compatible with high-resolution, live, and fluorescence imaging. Read More
J Virol Methods 2018 Nov 15;264:31-37. Epub 2018 Nov 15.
Instituto Nacional de Controle de Qualidade em Saúde (INCQS), Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil, 4365, Manguinhos, CEP: 21040-900, Rio de Janeiro, RJ, Brazil; Centro Brasileiro de Validação de Métodos Alternativos (BraCVAM), INCQS, FIOCRUZ, Brazil. Electronic address:
Rabies lethality is close to 100% and annually 15 million people receive post-exposure prophylaxis. Testing for vaccines against this zoonosis should ensure its quality. A standardized test by the National Institutes of Health (NIH) test, based on mice immunization and challenge, has been used to determine the potency of vaccine lots. Read More
J Travel Med 2018 Nov 16. Epub 2018 Nov 16.
Medical Director, Jackson Hole Travel and Tropical Medicine, Jackson Hole, Wyoming.
PLoS One 2018 16;13(11):e0207025. Epub 2018 Nov 16.
College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, Western Australia, Australia.
The lack of awareness regarding rabies amongst rural primary care health staff and their adverse practices towards the management of dog-bite wounds is a major contributor to the high incidence of rabies infection and subsequent human mortality in India. A Knowledge, Attitudes and Practices survey was carried out involving 54 nursing and non-nursing staff working in 18 rural Primary Health centres and sub-centres around Baramati town of Pune district in Western India. Multivariable logistic regression models were constructed to assess factors that influenced knowledge of rabies and practices towards management of dog-bite related wounds. Read More
Front Vet Sci 2018 30;5:262. Epub 2018 Oct 30.
Anses, Nancy Laboratory for Rabies and Wildlife, Malzéville, France.
infection was first described in free-ranging wildlife in France in 2001, with subsequent detection in hunter-harvested ungulates and badgers in areas where outbreaks of bovine tuberculosis (TB) were also detected in cattle. Increasing concerns regarding TB in wildlife led the French General Directorate for Food (DGAL) and the main institutions involved in animal health and wildlife management, to establish a national surveillance system for TB in free-ranging wildlife. This surveillance system is known as "Sylvatub. Read More
Epidemiol Infect 2018 Nov 15:1-8. Epub 2018 Nov 15.
Department of Internal Medicine,Division of Infectious Diseases, American University of Beirut Medical Center,Beirut,Lebanon.
The status of rabies as a neglected disease has made its eradication rather challenging in different parts of the world despite the availability of a successful vaccine. Lebanon, in particular, is a country endemic to the disease with several cases of rabies deaths reported over the past 30 years. The risk of rabies, however, has taken a new turn over the past few years in Lebanon with two emerging situations that have made the control of the disease rather challenging: the neighbouring Syrian war and the local garbage crisis. Read More
J Am Anim Hosp Assoc 2018 Nov 14. Epub 2018 Nov 14.
From the Department of Small Animal Internal Medicine, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon (A.M.); and Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado (J.V.).
This study described the rate of vaccine reactions in a population of dogs receiving vaccines after diagnosis of primary immune-mediated hemolytic anemia (IMHA). A secondary objective was to describe the time elapsed between vaccination and initial diagnosis of IMHA. A medical record search identified cases meeting criteria for primary IMHA. Read More
Virol J 2018 11 13;15(1):174. Epub 2018 Nov 13.
Key Laboratory for Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Background: Rabies is a fatal disease that is preventable when post exposure prophylaxis (PEP) is administered in a timely fashion. CpG oligodeoxynucleotides (ODNs) can trigger cells that express Toll-like receptor 9, and their immunopotentiation activity in an inactivated aluminum-adjuvanted rabies vaccine for dogs has been identified using mouse and dog models.
Methods: A human diploid cell rabies vaccine (HDCV) of humans and a CpG ODNs with cross-immunostimulatory activity in humans and mice were used to evaluate the immunogenicity and protective efficacy of CpG ODN in a mouse model that simulates human PEP. Read More