16,955 results match your criteria Rabies


Development and evaluation of polyclonal antibodies based antigen capture ELISA for detection of porcine rotavirus.

Anim Biotechnol 2022 May 20:1-8. Epub 2022 May 20.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Rotaviruses are rising as zoonotic viruses worldwide, causing the lethal dehydrating diarrhea in children, piglets, and other livestock of economic importance. A simple, swift, cost-effective, highly specific, and sensitive antigen-capture enzyme-linked immunosorbent assay (AC-ELISA) was developed for detection of porcine rotavirus-A (PoRVA) by employing rabbit (capture antibody) and murine polyclonal antibodies (detector antibody) produced against VP6 of PoRVA (RVA/Pig-tc/CHN/TM-a/2009/G9P23). Reactivity of the both polyclonal antibodies was confirmed by using an indirect ELISA, western-blot analysis and indirect fluorescence assay against rVP6 protein and PoRVA. Read More

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Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies.

Front Immunol 2022 3;13:872542. Epub 2022 May 3.

Hengyang Medical School, University of South China, Hengyang, China.

Background: Common vaccinations may have impacts on dementia risk, but current evidence is inconsistent. We therefore investigated the association between vaccinations and dementia risk by systematic review and meta-analysis approach.

Methods: We conducted an extensive search of PubMed, Embase, Cochrane Library, and Web of Science to identify studies that compared the risk of dementia in vaccinated versus unvaccinated populations. Read More

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Elimination of human rabies in Goa, India through an integrated One Health approach.

Nat Commun 2022 May 19;13(1):2788. Epub 2022 May 19.

Mission Rabies, Cranborne, Dorset, United Kingdom.

Dog-mediated rabies kills tens of thousands of people each year in India, representing one third of the estimated global rabies burden. Whilst the World Health Organization (WHO), World Organization for Animal Health (OIE) and the Food and Agriculture Organization of the United Nations (FAO) have set a target for global dog-mediated human rabies elimination by 2030, examples of large-scale dog vaccination programs demonstrating elimination remain limited in Africa and Asia. We describe the development of a data-driven rabies elimination program from 2013 to 2019 in Goa State, India, culminating in human rabies elimination and a 92% reduction in monthly canine rabies cases. Read More

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Rabies in a Dog Imported from Azerbaijan - Pennsylvania, 2021.

MMWR Morb Mortal Wkly Rep 2022 May 20;71(20):686-689. Epub 2022 May 20.

On June 16, 2021, rabies virus infection was confirmed in a dog included in a shipment of rescue animals imported into the United States from Azerbaijan. A multistate investigation was conducted to prevent secondary rabies cases, avoid reintroduction of a dog-maintained rabies virus variant (DMRVV), identify persons who might have been exposed and would be recommended to receive rabies postexposure prophylaxis, and investigate the cause of importation control failures. Results of a prospective serologic monitoring (PSM) protocol suggested that seven of 32 (22%) animals from the same shipment as the dog with confirmed rabies virus infection and who had available titer results after rabies vaccine booster had not been adequately vaccinated against rabies before importation. Read More

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[Effects of Covid-19 Pandemic on the Vaccine Activities on a Reference Immunization Center in Treichville, Côte D'ivoire].

Med Trop Sante Int 2021 Jun 28;1(2). Epub 2021 Apr 28.

Institut national d'hygiène publique, Côte d'Ivoire, BPV 14, Abidjan, Côte d'Ivoire.

Introduction: Since March 11, 2020, Côte d'Ivoire has been affected by the coronavirus epidemic, declared that same day as pandemic by WHO. March 11, 2021, one year after the pandemic, Côte d'Ivoire has notified 36,824 cases of Covid-19 patients and among them 211 have died. As of May 31, 2020, Côte d'Ivoire had already notified 2,833 cases and 33 deaths. Read More

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Hotspots in a cold land-reported cases of rabies in wildlife and livestock in Mongolia from 2012-2018.

Zoonoses Public Health 2022 May 18. Epub 2022 May 18.

Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA.

The epidemiological profile of rabies virus within Mongolia remains poorly characterized despite 21,302 domestic animal cases being reported between 1970-2005. This lack of knowledge is particularly concerning given that roughly 26% of the population lives a pastoral herding lifestyle and livestock production contributes up to 18% of Mongolia's total gross domestic product (GDP). The gaps in knowledge of the rabies disease ecology within Mongolia combined with the lack of routine vaccination of domestic animals and wildlife poses a significant threat to the more than 60 million heads of livestock within Mongolia. Read More

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Recombinant adeno-associated virus serotype 9 AAV-RABVG expressing a Rabies Virus G protein confers long-lasting immune responses in mice and non-human primates.

Emerg Microbes Infect 2022 May 17:1-26. Epub 2022 May 17.

Department of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

Three or four intramuscular doses of the inactivated human rabies virus vaccines are needed for pre- or post- exposure prophylaxis in humans. This procedure has made a great contribution to prevent human rabies deaths, which bring huge economic burdens in developing countries. Herein, a recombinant adeno-associated virus serotype 9, AAV9-RABVG, harboring a RABV G gene, was generated to serve as a single dose rabies vaccine candidate. Read More

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Dual-Mode Immunosensor for Electrochemiluminescence Resonance Energy Transfer and Electrochemical Detection of Rabies Virus Glycoprotein Based on Ru(bpy)-Loaded Dendritic Mesoporous Silica Nanoparticles.

Anal Chem 2022 May 17. Epub 2022 May 17.

State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.

Rabies is a serious zoonotic disease in almost all warm-blooded animals and causes fatal encephalitis. The detection of rabies virus (RABV) is critical and remains a significant challenge. Herein, an electrochemiluminescence resonance energy transfer (ECL-RET) and electrochemical (EC) dual-mode immunosensor was developed for highly sensitive detection of RABV glycoprotein. Read More

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Deactivation of the antiviral state by rabies virus through targeting and accumulation of persistently phosphorylated STAT1.

PLoS Pathog 2022 May 16;18(5):e1010533. Epub 2022 May 16.

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.

Antagonism of the interferon (IFN)-mediated antiviral state is critical to infection by rabies virus (RABV) and other viruses, and involves interference in the IFN induction and signaling pathways in infected cells, as well as deactivation of the antiviral state in cells previously activated by IFN. The latter is required for viral spread in the host, but the precise mechanisms involved and roles in RABV pathogenesis are poorly defined. Here, we examined the capacity of attenuated and pathogenic strains of RABV that differ only in the IFN-antagonist P protein to overcome an established antiviral state. Read More

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Analysis of the evolution, infectivity and antigenicity of circulating rabies virus strains.

Emerg Microbes Infect 2022 May 16:1-30. Epub 2022 May 16.

Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), No. 31 Huatuo Street, Daxing District, Beijing 102629, China.

Rabies virus has existed for thousands of years and is circulating in many species. In the present study, a total of 2896 rabies viruses isolated worldwide were phylogenetically classified into ten clusters based on the G gene sequence, and these clusters showed a close relationship with the hosts and regions that they were isolated from. Eighty-three representative G sequences were selected from ten clusters and were used to construct pseudoviruses using the VSV vector. Read More

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Case Report: Rabies Vaccine-Induced Thrombotic Thrombocytopenic Purpura in a Patient With Systemic Lupus Erythematosus.

Front Immunol 2022 25;13:851316. Epub 2022 Apr 25.

Department of Rheumatology and Immunology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangdong, China.

For patients with autoimmune diseases, vaccination is controversial. The use of vaccination in patients with autoimmune diseases is controversial. There are many reports of secondary thrombotic thrombocytopenic purpura cases after various vaccinations. Read More

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Meteorological and climatic variables predict the phenology of Ixodes ricinus nymph activity in France, accounting for habitat heterogeneity.

Sci Rep 2022 May 12;12(1):7833. Epub 2022 May 12.

Université de Lyon, INRAE, VetAgro Sup, UMR EPIA, 69280, Marcy l'Etoile, France.

Ixodes ricinus ticks (Acari: Ixodidae) are the most important vector for Lyme borreliosis in Europe. As climate change might affect their distributions and activities, this study aimed to determine the effects of environmental factors, i.e. Read More

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Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.

Nat Commun 2022 May 12;13(1):2659. Epub 2022 May 12.

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377, Munich, Germany.

Traumatic brain injury (TBI) results in deficits that are often followed by recovery. The contralesional cortex can contribute to this process but how distinct contralesional neurons and circuits respond to injury remains to be determined. To unravel adaptations in the contralesional cortex, we used chronic in vivo two-photon imaging. Read More

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Role of the glycoprotein thorns in anxious effects of rabies virus: Evidence from an animal study.

Brain Res Bull 2022 May 7;185:107-116. Epub 2022 May 7.

Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Rabies is a lethal infectious disease caused by rabies virus (RABV). Fear and anxiety are the distinguished symptoms in rabies patients. Fusion of RABV envelope glycoprotein (RVG) to host cell membrane initiates rabies pathogenesis via interacting with PDZ domain of signaling proteins. Read More

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Establishment and clinical validation of an in-cell-ELISA-based assay for the rapid quantification of Rabies virus neutralizing antibodies.

PLoS Negl Trop Dis 2022 May 10;16(5):e0010425. Epub 2022 May 10.

Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Neutralizing antibodies (nAbs) prevent the entry of viruses into permissive cells. Since nAbs represent correlates of protection against the Rabies lyssavirus, the presence of sufficient nAbs indicates effective vaccination. Accordingly, Rabies lyssavirus-specific nAb titers need to be determined in routine diagnostics to identify individuals being at risk of Rabies lyssavirus infections due to insufficient immunity. Read More

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The effects of geographical distributions of buildings and roads on the spatiotemporal spread of canine rabies: An individual-based modeling study.

PLoS Negl Trop Dis 2022 May 10;16(5):e0010397. Epub 2022 May 10.

Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok, Thailand.

Rabies is a fatal disease that has been a serious health concern, especially in developing countries. Although rabies is preventable by vaccination, the spread still occurs sporadically in many countries, including Thailand. Geographical structures, habitats, and behaviors of host populations are essential factors that may result in an enormous impact on the mechanism of propagation and persistence of the disease. Read More

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A World of Viruses Nested within Parasites: Unraveling Viral Diversity within Parasitic Flatworms (Platyhelminthes).

Microbiol Spectr 2022 May 10:e0013822. Epub 2022 May 10.

College of Marine Sciences, University of South Florida, Saint Petersburg, Florida, USA.

Because parasites have an inextricable relationship with their host, they have the potential to serve as viral reservoirs or facilitate virus host shifts. And yet, little is known about viruses infecting parasitic hosts except for blood-feeding arthropods that are well-known vectors of zoonotic viruses. Herein, we uncovered viruses of flatworms (phylum Platyhelminthes, group Neodermata) that specialize in parasitizing vertebrates and their ancestral free-living relatives. Read More

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Revealing the Cell Entry Dynamic Mechanism of Single Rabies Virus Particle.

Chem Res Chin Univ 2022 May 2:1-5. Epub 2022 May 2.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 P. R. China.

The rabies virus is a neurotropic virus that causes fatal diseases in humans and animals. Although studying the interactions between a single rabies virus and the cell membrane is necessary for understanding the pathogenesis, the internalization dynamic mechanism of single rabies virus in living cells remains largely elusive. Here, we utilized a novel force tracing technique based on atomic force microscopy(AFM) to record the process of single viral entry into host cell. Read More

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Preparation of Anti-Rabies Virus N Protein IgYs by DNA Immunization of Hens Using Different Types of Adjuvants.

J Poult Sci 2022 Apr;59(2):191-196

Graduate School of Kyoto Women's University, Higashiyama-ku, Kyoto 605-8501, Japan.

DNA immunization has been used to study vaccination methods and for production of specific antibodies. The present study aimed to apply DNA immunization to prepare specific IgYs, which react against rabies virus N protein (RV-N) and can be used to research and diagnose rabies virus. The DNA sequence of RV-N was ligated into a pcDNA 3. Read More

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Enhanced activity of AZD5582 and SM-164 in rabies virus glycoprotein-lactoferrin-liposomes to downregulate inhibitors of apoptosis proteins in glioblastoma.

Mater Sci Eng C Mater Biol Appl 2021 Dec 29:112615. Epub 2021 Dec 29.

Department of Chemical Engineering, National Chung Cheng University, Chia-Yi, Taiwan 62102, Taiwan, ROC.

Upregulated proliferation of neoplastic cells from suppressing apoptotic signals associated with the inhibitors of apoptosis proteins (IAP) makes difficult the achievement of therapeutic efficiency against glioblastoma multiforme. Studies in the last few years have witnessed a paradigm focusing on targeting IAP using its antagonists, such as Smac mimetics, to restrain tumor malignancy. A Smac mimetic compound needs to penetrate the blood-brain barrier (BBB), and must be internalized into cerebral tumor for improved chemotherapy. Read More

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December 2021

Rabies surveillance in the United States during 2020.

J Am Vet Med Assoc 2022 May 5:1-9. Epub 2022 May 5.

1Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA.

Objective: To provide epidemiological information on animal and human cases of rabies in the US during 2020 and summaries of 2020 rabies surveillance for Canada and Mexico.

Animals: All animals submitted for laboratory diagnosis of rabies in the US during 2020.

Procedures: State and territorial public health departments and USDA Wildlife Services provided 2020 rabies surveillance data. Read More

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[Anti-rabies vaccines applied in the Russian Federation and perspectives for their improvement].

Authors:
A L Elakov

Vopr Virusol 2022 May 5;67(2):107-114. Epub 2022 May 5.

FSBSI «Federal Scientific Center - All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K.I. Skryabin and Ya.R. Kovalenko of the Russian Academy of Sciences».

Rabies is almost ubiquitous (except in certain areas) and poses a significant danger to both animals and humans. Every year around 55,000 people die from this disease worldwide. In the Russian Federation alone 400,000- 450,000 patients annually apply for anti-rabies treatment. Read More

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Advice on Ukrainian pets that are not rabies compliant.

Vet Rec 2022 May;190(9):371

Defra, Seacole Building, 2 Marsham Street, London, SW1P 4DF.

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Characterization of Emergency Department Rabies Post-Exposure Prophylaxis Procedures with an Infectious Diseases Clinic Referral Process.

Hosp Pharm 2022 Feb 24;57(1):38-44. Epub 2020 Nov 24.

Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.

Rabies post-exposure prophylaxis (rPEP) in the emergency department (ED) is associated with high costs, complicated administration protocols, and a time-sensitive vaccination series that often requires ED follow-up visits for subsequent vaccine administration. This study sought to characterize the number of redirected vaccine administrations in those patients referred to ID Clinic, guideline compliance, and opportunities for improvement. Retrospective chart review of adult and pediatric patients presenting to the ED from 2016 to 2019 and prescribed rabies immunoglobulin. Read More

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February 2022

Occurrence and Risk Factors of Dog Bites in Northern Indigenous Communities: A Scoping Review.

Front Vet Sci 2022 18;9:777640. Epub 2022 Apr 18.

Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada.

The relationship between northern Indigenous people and dogs has evolved over the past years alongside events such as colonization, settlement, proliferation of snowmobiling and other socio-cultural and environmental changes. These changes have had negative impacts on this relationship, and with the endemic presence of arctic fox rabies, dog bites have become an important public health burden. The objective of this study was to synthesize the state of knowledge regarding the occurrence of dog bites and associated risk factors in the specific context of northern Indigenous communities. Read More

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Rabies prevention practices and associated factors among household heads in Bure Zuria district, North West Ethiopia.

Sci Rep 2022 May 5;12(1):7361. Epub 2022 May 5.

Department of Epidemiology and Biostatistics, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.

Rabies is a zoonotic viral disease that can occur in all warm blooded animals including humans. Vaccinating dogs can protect people from contracting rabies. Despite the availability of effective human and animal rabies vaccines, rabies prevention and control efforts are inadequate. Read More

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The impact of COVID-19 pandemic on rabies post-exposure prophylaxis services in Asia.

Hum Vaccin Immunother 2022 May 5:1-4. Epub 2022 May 5.

Rabies Treatment Unit, National Hospital, Colombo, Sri Lanka.

Human rabies is a preventable disease through post-exposure prophylaxis (PEP) in rabies endemic countries where enzootic cycle of dog rabies occurs. The COVID‑19 pandemic has induced an unprecedented challenge for under-funded and already stretched health‑care systems particularly in low- and middle-income countries, which are unfortunately bearing a huge burden of human rabies. An analysis of hospital-based PEP data in India, Nepal, Sri Lanka, and Thailand, focus group discussion and key informant interview have been carried out to better understand the impact of Covid-19 pandemic in human rabies prophylaxis. Read More

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Use of a Modified Preexposure Prophylaxis Vaccination Schedule to Prevent Human Rabies: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022.

MMWR Morb Mortal Wkly Rep 2022 May 6;71(18):619-627. Epub 2022 May 6.

Human rabies is an acute, progressive encephalomyelitis that is nearly always fatal once symptoms begin. Several measures have been implemented to prevent human rabies in the United States, including vaccination of targeted domesticated and wild animals, avoidance of behaviors that might precipitate an exposure (e.g. Read More

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An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.

Cell Rep 2022 05;39(5):110775

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92617, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92617, USA; UCI Mind, University of California, Irvine, Irvine, CA 92617, USA. Electronic address:

Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. Here we demonstrate the selective role of a ventral tegmental area DA projection to the amygdala (VTA→amygdala) for cocaine-induced anxiety but not cocaine reward or sensitization. Our rabies virus-mediated circuit mapping approach reveals a persistent elevation in spontaneous and task-related activity of inhibitory GABAergic cells from the bed nucleus of the stria terminalis (BNST) and downstream VTA→amygdala cells that can be detected even after a single cocaine exposure. Read More

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Vaccine update: The latest recommendations from ACIP.

J Fam Pract 2022 Mar;71(2):80-84

University of Arizona, Phoenix.

Here are the latest recommendations on the hepatitis, pneumococcal, zoster, rabies, and dengue vaccines. Read More

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