2,659 results match your criteria REM Sleep Behavior Disorder


Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression.

Brain 2022 May 20. Epub 2022 May 20.

The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.

Isolated REM sleep behaviour disorder (iRBD) is a synucleinopathy characterized by abnormal behaviours and vocalizations during REM sleep. Most iRBD patients develop dementia with Lewy bodies, Parkinson's disease, or multiple system atrophy over time. Patients with iRBD exhibit brain atrophy patterns that are reminiscent of those observed in overt synucleinopathies. Read More

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Exposure to Pesticides Predicts Prodromal Feature of Parkinson's Disease: Public Health Implications.

Mov Disord 2022 May;37(5):883-885

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

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REM sleep behavior disorder as a remote precedent to Creutzfeldt-Jakob disease.

Neurol Sci 2022 May 18. Epub 2022 May 18.

Northwestern University Feinberg School of Medicine, 676 N St Clair Street #701, Chicago, IL, 60611, USA.

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Prevalence and Correlates of Psychiatric Comorbidity and Multimorbidity in Parkinson's Disease and Atypical Parkinsonian Syndromes.

J Geriatr Psychiatry Neurol 2022 May 17:8919887221103575. Epub 2022 May 17.

Department of Psychiatry, Ringgold: 29148National Institute of Mental Health and Neurosciences, Bangalore, India.

Purpose: Psychiatric comorbidity in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) has been consistently associated with poor outcomes. However, the co-occurrence of multiple psychiatric disorders has been sparsely studied. This study examines the prevalence, patterns, and correlates of psychiatric comorbidity and multimorbidity among in-patients hospitalised with PD/APS. Read More

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Reduced Intracortical Facilitation to TMS in Both Isolated REM Sleep Behavior Disorder (RBD) and Early Parkinson's Disease with RBD.

J Clin Med 2022 Apr 20;11(9). Epub 2022 Apr 20.

Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.

Background: a reduced intracortical facilitation (ICF), a transcranial magnetic stimulation (TMS) measure largely mediated by glutamatergic neurotransmission, was observed in subjects affected by isolated REM sleep behavior disorder (iRBD). However, direct comparison between iRBD and Parkinson's disease (PD) with RBD is currently lacking.

Methods: resting motor threshold, contralateral cortical silent period, amplitude and latency of motor evoked potentials, short-interval intracortical inhibition, and intracortical facilitation (ICF) were recorded from 15 drug-naïve iRBD patients, 15 drug-naïve PD with RBD patients, and 15 healthy participants from the right First Dorsal Interosseous muscle. Read More

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Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.

Sci Rep 2022 May 13;12(1):7973. Epub 2022 May 13.

Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), De Crespigny Park, Box 089, London, SE5 8AF, UK.

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry. Read More

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Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study.

Neurology 2022 May 12. Epub 2022 May 12.

Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China

Background And Objectives: Individuals with a history of recurrent dream-enactment behaviors, but with subthreshold REM sleep without atonia levels for REM sleep behavior disorder (RBD) diagnosis, are currently classified to have prodromal RBD (pRBD). However, the REM sleep elevated EMG diagnostic cut-off, progression trajectory, and long-term neurodegenerative outcome of pRBD are not well understood. This study aimed to delineate the evolution of REM sleep EMG levels, determine the EMG cut-off score for diagnosing pRBD, and examine the risk for neurodegenerative diseases of pRBD. Read More

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Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy.

J Neurol 2022 Apr 30. Epub 2022 Apr 30.

Centre for Neuroscience Studies, Queen's University, 18 Stuart Street, Kingston, ON, K7L 3N6, Canada.

Objectives: This study (1) describes and compares saccade and pupil abnormalities in patients with manifest alpha-synucleinopathies (αSYN: Parkinson's disease (PD), Multiple System Atrophy (MSA)) and a tauopathy (progressive supranuclear palsy (PSP)); (2) determines whether patients with rapid-eye-movement sleep behaviour disorder (RBD), a prodromal stage of αSYN, already have abnormal responses that may indicate a risk for developing PD or MSA.

Methods: Ninety (46 RBD, 27 PD, 17 MSA) patients with an αSYN, 10 PSP patients, and 132 healthy age-matched controls (CTRL) were examined with a 10-min video-based eye-tracking task (Free Viewing). Participants were free to look anywhere on the screen while saccade and pupil behaviours were measured. Read More

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Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson's disease.

NPJ Parkinsons Dis 2022 Apr 29;8(1):54. Epub 2022 Apr 29.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, 310009, Hangzhou, Zhejiang, China.

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein and glymphatic system dysfunction. However, evidence accumulating primarily based on clinical data to support glymphatic system dysfunction in patients with iRBD and PD is currently insufficient. Read More

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Impaired bed mobility in prediagnostic and de novo Parkinson's disease.

Parkinsonism Relat Disord 2022 Apr 21;98:47-52. Epub 2022 Apr 21.

Department of Neurology, Antwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium; Faculty of Medicine and Health Sciences, Translational Neurosciences, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium; Born-Bunge Institute, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address:

Background: Wearable technology research suggests that nocturnal movements are disturbed in early Parkinson's disease (PD). In this study, we investigate if patients also already experience impaired bed mobility before PD diagnosis. Furthermore, we explore its association with motor and nonmotor features and its value for phenoconversion and disease progression prediction. Read More

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Rapid eye movement sleep behaviour disorder: Past, present, and future.

J Sleep Res 2022 Apr 25:e13612. Epub 2022 Apr 25.

Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.

This manuscript presents an overview of REM sleep behaviour disorder (RBD) with a special focus on European contributions. After an introduction examining the history of the disorder, we address the pathophysiological and clinical aspects, as well as the diagnostic issues. Further, implications of RBD diagnosis and biomarkers are discussed. Read More

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The REM-sleep-related characteristics of narcolepsy: a nation-wide multicenter study in Turkey, the REMCON study.

Sleep Med 2022 Apr 2;94:17-25. Epub 2022 Apr 2.

Department of Neurology, Sleep and Disorders Unit, Istanbul University-Cerrahpasa, Medical Faculty of Cerrahpasa, Istanbul, Turkey. Electronic address:

Introduction: Narcolepsy type 1 (NT1) is caused by hypocretin deficiency, the pathophysiology of narcolepsy type 2 (NT2) has not been delineated. Except for the hypocretin deficiency and cataplexy, all clinical and laboratory features used in the diagnosis of NT2 are identical to those used for NT1. The aim of this study was to assess the rapid eye movement (REM) sleep-related characteristics in the patients with narcolepsy; the characteristics of REM sleep in polysomnography (PSG) and multiple sleep latency test (MSLT) recordings, the quantification of REM sleep without atonia (RSWA) and atonia index, and the analysis of rapid eye movements (REMs) during REM sleep. Read More

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[Pre-pandemic melatonin treatment for sleep disorders and COVID-19 infection. A retrospective cross-sectional study].

Vertex 2022 Mar;XXXIII(155):13-24

Servicio de Neurología. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Introduction: Melatonin is a safe medication with multiple uses in sleep medicine for the treatment of circadian rhythm disorders, insomnia, and REM sleep behavior disorder. In view that melatonin has been recommended as an adjuvant treatment in COVID-19 pandemic mainly due to its anti-inflammatory properties, the objective of the present study was to evaluate the history of COVID-19 infection and the requirement of hospitalization in a group of adult patients previously treated with melatonin for various sleep disorders.

Material And Methods: This is a retrospective cross-sectional study of data from a closed population of 110 adult patients at a University Hospital treated with melatonin for various sleep disorders, analyzed until the onset of COVID-19 pandemic. Read More

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Brain Metabolism Related to Mild Cognitive Impairment and Phenoconversion in Patients With Isolated REM Sleep Behavior Disorder.

Neurology 2022 Apr 18. Epub 2022 Apr 18.

Department of Nuclear Medicine, Seoul National University-Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea, Republic of.

Background And Objectives: Mild cognitive impairment (MCI) in isolated REM sleep behavior disorder (iRBD) is a risk factor for the subsequent neurodegeneration. We aimed to identify brain metabolism and functional connectivity changes related to MCI in patients with iRBD and the neuroimaging markers' predictive value for phenoconversion.

Methods: This is a prospective cohort study of iRBD patients with a mean follow-up of 4. Read More

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Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams.

Comput Math Methods Med 2022 8;2022:6181943. Epub 2022 Apr 8.

Xinjiang Medical University, Xinshi District, Urumqi 830011, China.

Background: Insomnia is a sleep disorder and the cause of many healthy problems. However, there are few studies on patients with insomnia and dreaminess at present. Therefore, this study is aimed at exploring the pathological molecular mechanisms and potential diagnostic and therapeutic targets related to insomnia patients with more dreams. Read More

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Common Sleep Disorders in Adults: Diagnosis and Management.

Am Fam Physician 2022 04;105(4):397-405

Cooper University HealthCare, Camden, NJ, USA.

Sleep disorders are common in the general adult population and are associated with adverse effects such as motor vehicle collisions, decreased quality of life, and increased mortality. Patients with sleep disorders can be categorized into three groups: people with problems falling asleep, people with behavior and movement disturbances during sleep, and people with excessive daytime sleepiness. Insomnia, the most common sleep disorder, is defined by difficulty initiating sleep, maintaining sleep, or both, resulting in daytime consequences. Read More

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REM sleep behavior disorder and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau and phosphorylated tau in Parkinson's disease: a cross-sectional and longitudinal study.

J Neurol 2022 Apr 15. Epub 2022 Apr 15.

School of Medicine, Tehran University of Medical Science, Tehran, Iran.

Background: Proteinopathies as a consequence of cellular pathological pathways associated with Parkinson's disease (PD), leading to alteration of protein aggregation in cerebrospinal fluid (CSF). Rapid eye movement (REM) sleep behavior disorder (RBD is generally accepted as a prognostic factor predicting neurodegeneration, worse cognitive impairment, and the development of dementia PD.

Aim: Here we aimed to investigate the difference and longitudinal alteration of the CSF level of α-synuclein (α-syn), amyloid βeta (Aβ1-42), total tau (t-tau), and phosphorylated tau (p-tau) in PD subjects with RBD and without RBD. Read More

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Increased blood pressure variability is associated with probable rapid eye movement sleep behaviour disorder in elderly hypertensive patients.

Blood Press 2022 12;31(1):40-46

Division of Cardiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.

Purpose: An increased blood pressure variability (BPV) has been reported to be associated with older age and cognitive dysfunction; however, associations between increased BPV and rapid eye movement sleep behaviour disorder (RBD) has not been thoroughly investigated in patients without clinical Lewy body diseases.

Materials And Methods: In frailty outpatient clinic, we evaluated ambulatory BP, RBD screening questionnaire (RBDSQ), and beat-to-beat heart rate variability during positional change from sitting to standing in 112 elderly hypertensive patients.

Results: The mean age was 81. Read More

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December 2022

REM Sleep Behavior Disorder and Visual Hallucinations in a Pathologically Confirmed Case of Corticobasal Degeneration.

Mov Disord Clin Pract 2022 Apr 6;9(3):383-385. Epub 2022 Jan 6.

Department of Clinical and Movement Neurosciences, Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology London United Kingdom.

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Evolution patterns of probable REM sleep behavior disorder predicts Parkinson's disease progression.

NPJ Parkinsons Dis 2022 Apr 5;8(1):36. Epub 2022 Apr 5.

Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson's disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson's disease (PD). 281 de novo PD patients from the Parkinson's Progression Markers Initiative database were included. Read More

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Dysautonomia in Parkinson's Disease: Impact of Glucocerebrosidase Gene Mutations on Cardiovascular Autonomic Control.

Front Neurosci 2022 15;16:842498. Epub 2022 Mar 15.

Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Evidence from clinical practice suggests that PD patients with the Glucocerebrosidase gene mutations (GBA-PD) are characterized by more severe dysautonomic symptoms than patients with idiopathic PD (iPD). Therefore, an accurate assessment of cardiovascular autonomic control (CAC) is necessary to clarify the role of GBA mutations in the pathophysiology of PD. We evaluated the CAC at rest and during orthostatic challenge of 15 iPD, 15 GBA-PD and 15 healthy controls (CTR). Read More

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Sleep Dysfunction and Grey Matter Volume.

Curr Neurol Neurosci Rep 2022 04 2;22(4):275-283. Epub 2022 Apr 2.

Department of Neurosurgery, Medical Academy, Lithuanian University of Health Sciences , Kaunas, Lithuania.

Purpose Of Review: With the voxel-based morphometry (VBM), structural imaging studies turned into new directions aiming to explore neurological disorders differently. This approach helps identify possible pathophysiological correlations between neuroanatomical grey matter (GM) structures in patients with sleep dysfunction. This article reviews recent findings on GM structure in various sleep disorders and possible causes of disturbed sleep and discusses the future perspectives. Read More

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Aquaporin-4 Polymorphisms Are Associated With Cognitive Performance in Parkinson's Disease.

Front Aging Neurosci 2021 9;13:740491. Epub 2022 Mar 9.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objective: Aquaporin-4 (AQP4) facilitates a sleep-enhanced interstitial brain waste clearance system. This study was conducted to determine the clinical implication of polymorphisms in Parkinson's disease (PD).

Methods: Three-hundred and eighty-two patients with PD and 180 healthy controls with a mean follow-up time of 66. Read More

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The additional diagnostic benefits of performing both video-polysomnography and prolonged video-EEG-monitoring: When and why.

Clin Neurophysiol Pract 2022 26;7:98-102. Epub 2022 Feb 26.

Department of Neurology, Medical University of Innsbruck, Austria.

Objective: Video-polysomnography (VPSG) and prolonged video-EEG-monitoring (pVEEG-M) are neurophysiological investigation modalities. Depending on indication either is performed, but occasionally patients undergo both (during the same or separate stays). We sought to assess the reasons and potential benefits of dual diagnostic assessments with both modalities. Read More

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February 2022

Aggressiveness in the dreams of drug-naïve and clonazepam-treated patients with isolated REM sleep behavior disorder.

Sleep Med 2022 Apr 5;92:19-23. Epub 2022 Mar 5.

Department of Mental Health and Addiction, ASST Santi Paolo e Carlo, Milan, Italy; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.

Background: Although aggressive dream content is considered a distinctive feature of REM Sleep Behavior Disorder (RBD) and patients often report violent dreams during medical interviews, nonviolent behaviors (eating, drinking, urinating) and pleasant actions (e.g laughing, singing, dancing) or simply elemental, jerky limb movements are frequently observed during video-polysomnography. As a first-line pharmacological treatment, clonazepam has been shown to reduce motor symptoms during REM sleep, but its effect on dream content remains unclear. Read More

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Clinical manifestation of isolated REM sleep behavior disorder patients after modest-to-long disease duration.

Sleep 2022 Mar 23. Epub 2022 Mar 23.

Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Study Objectives: Patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) are known to be at risk of neurodegenerative diseases but the time process of neurodegeneration remains unclear and its ethnic difference is rarely discussed. The objective of this study was to investigate clinical manifestation of iRBD according to disease duration in a Korean cohort.

Methods: Patients who had been diagnosed with iRBD for at least five years were tracked and those currently remaining as iRBD were invited for motor, autonomic, olfactory, color discrimination, and cognitive tests. Read More

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[Discrimination of Chin Electromyography in REM Sleep Behavior Disorder Using Deep Learning].

Nihon Eiseigaku Zasshi 2022 ;77(0)

Graduate School of Engineering, University of Fukui.

Objective: The confirmation of abnormal behavior during video monitoring in polysomnography (PSG) and the frequency of rapid eye movement (REM) sleep without atonia (RWA) during REM sleep based on physiological indicators are essential diagnostic criteria for the diagnosis of REM sleep behavior disorder (RBD). However, no clear criteria have been established for the determination of the tonic and phasic activities of RWA. In this study, we investigated an RWA decision program that simulates visual inspection by clinical laboratory technicians. Read More

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rs3910105 Is Associated With Development of Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease.

Front Neurosci 2022 3;16:832550. Epub 2022 Mar 3.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background And Purpose: Rapid eye movement (REM) Rapid eye movement sleep behavior disorder (RBD) is a common non-motor symptom of PD. However, the association between the rs3910105 genotype and RBD in Parkinson's disease (PD) remains unclear.

Methods: This study used Parkinson's Progression Markers Initiative (PPMI) data and included 270 patients with newly diagnosed PD without RBD who were divided into rs3910105 C carriers (CC+CT; = 187) and TT carriers ( = 83). Read More

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Generalized EEG Slowing Across Phasic REM Sleep, Not Subjective RBD Severity, Predicts Neurodegeneration in Idiopathic RBD.

Nat Sci Sleep 2022 11;14:407-418. Epub 2022 Mar 11.

Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Purpose: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is the prodromal marker of α-synuclein degeneration with markedly high predictive value. We aim to evaluate the value of electroencephalography (EEG) data during rapid eye movement (REM) sleep and subjective RBD severity in predicting the conversion to neurodegenerative diseases in iRBD patients.

Methods: At the baseline, iRBD patients underwent clinical assessment and video-polysomnography (PSG). Read More

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Interbeat interval-based sleep staging: work in progress toward real-time implementation.

Physiol Meas 2022 03 17;43(2). Epub 2022 Mar 17.

Sleep Number Labs, San Jose, CA, United States of America.

. Cardiac activity changes during sleep enable real-time sleep staging. We developed a deep neural network (DNN) to detect sleep stages using interbeat intervals (IBIs) extracted from electrocardiogram signals. Read More

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