1,857 results match your criteria REM Sleep Behavior Disorder


The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 Feb 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
February 2019

Detection of REM sleep behaviour disorder by automated polysomnography analysis.

Clin Neurophysiol 2019 Feb 6;130(4):505-514. Epub 2019 Feb 6.

University of Oxford, Institute of Biomedical Engineering, Dept. Engineering Sciences, Oxford, UK.

Objective: Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification.

Methods: Analysis was assessed using a limited polysomnography montage from 53 participants with RBD and 53 age-matched healthy controls. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.011DOI Listing
February 2019

Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies.

Sleep Med 2018 Dec 18;55:62-68. Epub 2018 Dec 18.

Department of Neurology, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal; CEDOC, Chronic Diseases Research Center, NOVA Medical School, USA.

Introduction: Sleep dysfunction is frequent in Dementia with Lewy Bodies (DLB), but polysomnographic (PSG) data is scarce. Our objectives were to: (1) compare PSG data between DLB patients and age normative values (NV), Parkinson's Disease (PD) and idiopathic REM sleep behavior disorder (iRBD) patients; (2) evaluate the relation between of OSA, Fluctuations and Hypersomnolence and PSG data.

Methods: We selected all consecutive patients with DLB, PD and iRBD that underwent video-PSG during a two year period. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.006DOI Listing
December 2018

Nightmare disorder and REM sleep behavior disorder in inflammatory arthritis: Possibility beyond neurodegeneration.

Brain Behav 2019 Feb 15:e01230. Epub 2019 Feb 15.

Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.

Objectives: To investigate the prevalence of REM sleep behavior disorder (RBD) in patients with inflammatory arthritis (IA) to ascertain if RBD could be an internal red flag signaling a fluctuating state of inflammation based on the theory of "protoconsciousness".

Materials & Methods: One hundred and three patients with a confirmed diagnosis of IA were consecutively recruited. The patients underwent general (IA activity, functional status, laboratory tests) and neurological evaluations. Read More

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http://dx.doi.org/10.1002/brb3.1230DOI Listing
February 2019

Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.

Eur J Neurol 2019 Feb 15. Epub 2019 Feb 15.

Philipps University, Marburg, Germany.

Background: Visualization of phosphorylated α-synuclein at serine 129 (p-syn) in skin nerves is a promising test for the in vivo diagnosis of synucleinopathies. Here we aimed to establish the intra- and inter-laboratory reproducibility of quantification of intraneural p-syn immunoreactivity in two laboratories with a major expertise (Würzburg and Bologna).

Methods: We enrolled 43 patients affected by Parkinson's disease (PD: 21 patients), Dementia with Lewy Body (DLB: 1), REM sleep behavior disorder (RBD: 11), Multiple System Atrophy (MSA-P: 4) and small fiber neuropathy (SFN: 6). Read More

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http://dx.doi.org/10.1111/ene.13939DOI Listing
February 2019

MIBG Myocardial Scintigraphy Identifies Premotor PD/DLB During a Negative DAT Scan Period: Second Report.

Mov Disord Clin Pract 2019 Jan 9;6(1):46-50. Epub 2018 Nov 9.

Gastroenterology, Internal Medicine, Sakura Medical Center Toho University Sakura Japan.

Objectives: Neuroimaging markers for Parkinson's disease (PD)/dementia with Lewy bodies (DLB) include dopamine transporter (DAT) scanning and metaiodobenzylguanidine (MIBG) myocardial scintigraphy. It is unknown which marker is useful to identify the premotor phase PD/DLB. We reported four patients who, during a negative DAT scan period, had a positive MIBG result that suggested premotor PD/DLB. Read More

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http://dx.doi.org/10.1002/mdc3.12697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335543PMC
January 2019
1 Read

Long Lag Between Drug-induced Parkinsonism and Idiopathic Parkinson's Disease in Idiopathic REM Sleep Behavior Disorder.

Mov Disord Clin Pract 2018 Mar-Apr;5(2):203-205. Epub 2018 Jan 10.

Department of Neurology and Neurosurgery McGill University Montreal Quebec Canada.

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http://dx.doi.org/10.1002/mdc3.12576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336185PMC
January 2018
1 Read

Brain Glucose Metabolism Heterogeneity in Idiopathic REM Sleep Behavior Disorder and in Parkinson's Disease.

J Parkinsons Dis 2019 ;9(1):229-239

Institutes of Cognitive Sciences and Technologies, CNR, Rome, Italy.

Background/objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function.

Methods: Thirty-six iRBD patients (64. Read More

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http://dx.doi.org/10.3233/JPD-181468DOI Listing
January 2019

Sleep disturbances are common in patients with autoimmune encephalitis.

J Neurol 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.

Objectives: Autoimmune encephalitis (AE) is increasingly recognized as an important cause of subacute cognitive decline, seizures, and encephalopathy, with an ever-broadening clinical phenotype. Sleep disturbances are reported in AE patients, including rapid eye movement sleep behavior disorder, hypersomnia, fragmented sleep, and sleep-disordered breathing; however, the prevalence of sleep disturbances and contributions to outcomes in AE patients remain unknown. There is a need to determine the prevalence of sleep disturbances in AE patients, and to clarify the relationship between specific autoantibodies and disruptions in sleep. Read More

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http://dx.doi.org/10.1007/s00415-019-09230-2DOI Listing
February 2019
1 Read

Correlations between dopaminergic dysfunction and abnormal metabolic network activity in REM sleep behavior disorder.

J Cereb Blood Flow Metab 2019 Feb 10:271678X19828916. Epub 2019 Feb 10.

1 PET Center, Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Striatal dopamine transporter (DAT) deficiency and abnormal expression of Parkinson's disease (PD)-related pattern (PDRP) have been observed in patients with idiopathic REM sleep behavior disorder (IRBD). This study aimed to investigate the correlations between these two measures with comparison to PD using a dual tracer imaging design. Age-matched 37 IRBD patients, 86 PD patients, and 15 control subjects underwent concurrent PET scans with C-CFT to quantify dopaminergic dysfunction and F-FDG to quantify PDRP expression. Read More

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http://dx.doi.org/10.1177/0271678X19828916DOI Listing
February 2019
1 Read

Trauma-Associated Sleep Disorder: A Posttraumatic Stress/REM Sleep Behavior Disorder Mash-Up?

J Clin Sleep Med 2019 Feb 4. Epub 2019 Feb 4.

Abstract: Trauma-associated sleep disorder (TASD) is a parasomnia sharing characteristics of post-traumatic stress disorder (PTSD) and REM sleep behavior disorder (RBD) including dream-enactment behavior (DEB). Here we report REM sleep without atonia (RSWA) and other neurological features in a patient with complex vocal and motor DEB following traumatic combat military exposure. Post-discharge, his wife observed frequent yelling and jerking during sleep with dream mentation reminiscent of traumatic military experiences. Read More

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February 2019
1 Read

Abnormal nocturnal behavior due to hypoglycemia: A case report.

Medicine (Baltimore) 2019 Feb;98(6):e14405

Department of Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai.

Rationale: Hypoglycemia, which is characterized mainly by palpitations, dizziness, and sweating, is common and easy to identify. However, some other symptoms, such as mental disorder or abnormal behavior, are atypical, which may lead to a misdiagnosis of epilepsy, sleepwalking, infarction, or mental disorder, among others.

Patient Concerns: We report a case of a patient with type 2 diabetes who presented with abnormal nocturnal behavior due to hypoglycemia. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902080-0007
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http://dx.doi.org/10.1097/MD.0000000000014405DOI Listing
February 2019
7 Reads

Newly Identified Sleep-Wake and Circadian Circuits as Potential Therapeutic Targets.

Sleep 2019 Feb 5. Epub 2019 Feb 5.

epartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, NeuroNexus Institute, Graduate Program in Neuroscience - Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA.

Optogenetics and chemogenetics are powerful tools, allowing the specific activation or inhibition of targeted neuronal sub-populations. Application of these techniques to sleep and circadian research has resulted in the unveiling of several neuronal populations that are involved in sleep-wake control, and allowed a comprehensive interrogation of the circuitry through which these nodes are coordinated to orchestrate the sleep-wake cycle. In this review, we discuss six recently described sleep-wake and circadian circuits that show promise as therapeutic targets for sleep medicine. Read More

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http://dx.doi.org/10.1093/sleep/zsz023DOI Listing
February 2019
2 Reads

Imaging in prodromal dementia with lewy bodies: Where do we stand?

Int J Geriatr Psychiatry 2019 Feb 3. Epub 2019 Feb 3.

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality Newcastle Upon Tyne, UK.

Objectives: The aim of this review was to provide an overview of the literature on imaging in prodromal Dementia with Lewy bodies (DLB).

Design: Systematic PubMed search and literature review.

Results: Diagnostic classification of the prodromal DLB stage remains to be established but is likely to require imaging biomarkers to improve diagnostic accuracy. Read More

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http://doi.wiley.com/10.1002/gps.5071
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http://dx.doi.org/10.1002/gps.5071DOI Listing
February 2019
4 Reads

Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder.

NPJ Parkinsons Dis 2019 29;5. Epub 2019 Jan 29.

15Department of Neurology, Philipps University, Marburg, Germany.

REM sleep behavior disorder (RBD) is strongly associated with development of Parkinson's Disease and other α-synuclein-related disorders. Dopamine transporter (DAT) binding deficit predicts conversion to α-synuclein-related disorders in individuals with RBD. In turn, identifying which individuals with RBD have the highest likelihood of having abnormal DAT binding would be useful. Read More

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http://dx.doi.org/10.1038/s41531-018-0073-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351563PMC
January 2019
1 Read

Young-Onset Dementia with Lewy Bodies.

Case Rep Neurol 2018 Sep-Dec;10(3):363-368. Epub 2018 Dec 20.

Radiology, Sakura Medical Center, Toho University, Sakura, Japan.

Young-onset (< 65 years) dementia is a challenging clinical problem. A 61-year-old man visited our clinic because of a 2-year history of mild cognitive impairment of the executive disorder type. He was initially suspected of having young-onset Alzheimer's disease due to the lack of motor signs or hippocampal atrophy by conventional brain MRI. Read More

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http://dx.doi.org/10.1159/000495748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341340PMC
December 2018
4 Reads

Diagnostic Criteria, Differential Diagnosis, and Treatment of Minor Motor Activity and Less Well-Known Movement Disorders of Sleep.

Curr Treat Options Neurol 2019 Jan 19;21(1). Epub 2019 Jan 19.

Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Purpose Of Review: Sleep-related movement disorders (SRMD) include several different motor activities during sleep. Few of them are well known and well classified, whereas others are minor motor disorders of sleep which are neither thoroughly characterized and classified nor have been extensively investigated to clarify their pathogenesis and clinical relevance. This review will focus on those minor sleep-related movement disorders. Read More

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http://dx.doi.org/10.1007/s11940-019-0543-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339673PMC
January 2019
2 Reads

Trauma-Associated Sleep Disturbances: a Distinct Sleep Disorder?

Curr Sleep Med Rep 2018 Jun 26;4(2):143-148. Epub 2018 Apr 26.

VA Portland Health Care System.

Purpose Of Review: This paper describes a newly proposed sleep disorder, trauma-associated sleep disorder (TSD). Whether or not this represents a truly unique condition is controversial. In this paper, we describe the overlapping features and differences between TSD, post-traumatic stress disorder (PTSD) and Rapid Eye Movement (REM) sleep behavior disorder (RBD). Read More

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http://link.springer.com/10.1007/s40675-018-0119-2
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http://dx.doi.org/10.1007/s40675-018-0119-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330699PMC
June 2018
4 Reads

CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.

Curr Neurol Neurosci Rep 2019 Jan 14;19(2). Epub 2019 Jan 14.

Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy.

Purpose Of Review: Idiopathic REM sleep behavior disorder (iRBD) is one of the most significant prodromal manifestations of synucleinopathies. Different predictive biomarkers for iRBD conversion have been investigated, but scarce data are present in literature about the predictive role of cerebrospinal fluid (CSF) biomarkers. In this review, we focus on CSF biomarkers in patients with both iRBD and RBD associated with synucleinopathies to explore their potential predictive power. Read More

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http://link.springer.com/10.1007/s11910-019-0918-y
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http://dx.doi.org/10.1007/s11910-019-0918-yDOI Listing
January 2019
4 Reads

Spinocerebellar ataxia type 31 associated with REM sleep behavior disorder: a case report.

BMC Neurol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Neurology, University of Yamanashi, 1110 Shimokatou, Yamanashi, 409-3898, Japan.

Background: Spinocerebellar ataxia type 31 (SCA 31) is a slowly progressive neurodegenerative disorder characterized by pure cerebellar ataxia. Unlike other CAG repeat diseases, sleep-related problems have not been reported in patients with SCA 31 so far.

Case Presentation: A 67-year-old woman was admitted to our hospital with dysarthria and gait disturbance after onset age of 62 years. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1238-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329112PMC
January 2019
8 Reads

Gray matter substrates of depressive and anxiety symptoms in idiopathic REM sleep behavior disorder.

Parkinsonism Relat Disord 2018 Dec 17. Epub 2018 Dec 17.

Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada; Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, QC, Canada; Research Centre, Institut universitaire de gériatrie de Montréal, Montreal, QC, Canada. Electronic address:

Introduction: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Depressive and anxiety symptoms are frequent features of PD, DLB and iRBD, and some studies suggest that depressive symptoms are a marker for neurodegeneration in iRBD. However, the pathophysiology of depressive and anxiety symptoms in iRBD is still unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13538020183055
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http://dx.doi.org/10.1016/j.parkreldis.2018.12.020DOI Listing
December 2018
4 Reads
3.972 Impact Factor

Smiling asleep: A study of happy emotional expressions during adult sleep.

J Sleep Res 2019 Jan 6:e12814. Epub 2019 Jan 6.

Sleep Disorder Unit, Pitie-Salpetriere University Hospital, APHP, Paris, France.

Human foetuses and newborns smile first during sleep, before they smile while awake and interacting with caregivers. Whether smiling persists during adult sleep, and expresses inner joy, is yet unknown. Smiles were looked for during night-time video-polysomnography combined with electromyography of the zygomatic and orbicularis oculi muscles in 100 controls, 22 patients with sleepwalking and 52 patients with rapid eye movement (REM) sleep behaviour disorder. Read More

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http://dx.doi.org/10.1111/jsr.12814DOI Listing
January 2019
3 Reads

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly.

Oncotarget 2018 Dec 4;9(95):36732-36733. Epub 2018 Dec 4.

Stefanie Lerche: Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.18632/oncotarget.26417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298407PMC
December 2018

[Chinese expert consensus on the assessment and management of stroke-related sleep disorders].

Authors:

Zhonghua Nei Ke Za Zhi 2019 Jan;58(1):17-26

Stroke-related sleep disorders (SSD) are common symptoms after stroke, which are common but easily ignored. Studies have shown that sleep disorders in stroke patients would have negative impact on prognosis. However, there is still a lack of consensus and guidance on SSD evaluation and management worldwide. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.01.004DOI Listing
January 2019
2 Reads

Risk factors for possible REM sleep behavior disorder: A CLSA population-based cohort study.

Neurology 2018 Dec 26. Epub 2018 Dec 26.

From the Integrated Program in Neuroscience (C.Y.), Department of Neurology and Neurosurgery (S.-M.F., R.B.P.), Department of Epidemiology and Biostatistics and Occupational Health (C.W.), and Department of Medicine (C.W., A.P.), McGill University; Centre de Recherche du Centre hospitalier de l'Université de Montréal (M.R.K.); and Research Institute of the McGill University Health Centre (C.W., A.P.), Montreal, Quebec, Canada.

Objective: To assess sociodemographic, socioeconomic, and clinical correlates of idiopathic REM sleep behavior disorder (RBD) in a 30,097-person national cohort.

Methods: Participants 45 to 85 years of age in Canada were collected as part of the Canadian Longitudinal Study on Aging. Possible RBD (pRBD) was screened with the REM Sleep Behavior Disorder Single-Question Screen, a questionnaire with 94% specificity and 87% sensitivity. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006849DOI Listing
December 2018
19 Reads

Response to letter to Editor.

J Neurol Sci 2019 Feb 7;397:48-49. Epub 2018 Dec 7.

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jns.2018.12.008DOI Listing
February 2019
1 Read

Comparison of EMG power during sleep from the submental and frontalis muscles.

Nat Sci Sleep 2018 6;10:431-437. Epub 2018 Dec 6.

Advanced Brain Monitoring, Carlsbad, CA,USA,

Objective: Submentalis electromyography (EMG) and frontalis electromyography (EMG) muscle activities have been used to assist in the staging of sleep and detection of disruptions in sleep. This study was designed to assess the concordance between EMG and EMG power, by and across sleep stages.

Methods: Forty-three records with simultaneous acquisition of differential signals from the submental and frontalis muscles were evaluated. Read More

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https://www.dovepress.com/comparison-of-emg-power-during-sle
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http://dx.doi.org/10.2147/NSS.S189167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287659PMC
December 2018
5 Reads

Exploration of cardiac sympathetic adrenergic nerve activity in narcolepsy.

Clin Neurophysiol 2019 Mar 6;130(3):412-418. Epub 2018 Dec 6.

Sleep-Wake Disorders Centre, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, France; National Reference Network for Narcolepsy, CHU Montpellier, France; INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France. Electronic address:

Objective: To compare cardiac sympathetic adrenergic nerve activity in patients with narcolepsy type 1 (NT1) and controls using I-MIBG myocardial scintigraphy, and to determine the clinical and neurophysiological variables associated with I-MIBG scintigraphy results in NT1.

Methods: Fifty-six NT1 patients and 91 controls without neurological diseases underwent a cardiac scintigraphy. MIBG uptake was quantified by delayed heart/mediastinum (H/M) ratio. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.014DOI Listing
March 2019
2 Reads

Carriers of both GBA and LRRK2 mutations, compared to carriers of either, in Parkinson's disease: Risk estimates and genotype-phenotype correlations.

Parkinsonism Relat Disord 2018 Dec 13. Epub 2018 Dec 13.

The Movement Disorders Institute, Department of Neurology and Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Introduction: The clinical characteristics of Parkinson's disease (PD) associated with both the LRRK2 p.G2019S mutation and a GBA variant (LRRK2-GBA-PD) have not yet been determined.

Methods: In this retrospective observational study of Ashkenazi-Jewish (AJ) PD patients, we describe the clinical course and characteristics of LRRK2-GBA-PD and estimate the risk to develop PD for the double mutation carriers. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2018.12.014DOI Listing
December 2018
1 Read
3.972 Impact Factor

Home monitoring of sleep with a temporary-tattoo EEG, EOG and EMG electrode array: a feasibility study.

J Neural Eng 2018 Dec 19;16(2):026024. Epub 2018 Dec 19.

Tel Aviv Sourasky Medical Center (TASMC), Tel Aviv, Israel. Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.

Objective: Circadian and sleep dysfunction have long been symptomatic hallmarks of a variety of devastating neurodegenerative conditions. The gold standard for sleep monitoring is overnight sleep in a polysomnography (PSG) laboratory. However, this method has several limitations such as availability, cost and being labour-intensive. Read More

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http://iopscience.iop.org/article/10.1088/1741-2552/aafa05
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http://dx.doi.org/10.1088/1741-2552/aafa05DOI Listing
December 2018
1 Read

Non-motor predictors of freezing of gait in Parkinson's disease.

Gait Posture 2019 Feb 6;68:311-316. Epub 2018 Dec 6.

Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA; Department of Neurology and Neurological Sciences, Stanford University, USA. Electronic address:

Background: The etiology of freezing of gait in Parkinson's disease (PD) is yet to be clarified. Non-motor risk factors including cognitive impairment, sleep disturbance and mood disorders have been shown in freezing of gait.

Research Question: We aimed to determine the predictive value of non-motor features in freezing of gait development. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2018.12.009DOI Listing
February 2019
1 Read

Protective effects of REM sleep without atonia against obstructive sleep apnea in patients with idiopathic REM sleep behavior disorder.

Sleep Med 2019 Feb 19;54:116-120. Epub 2018 Nov 19.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: This study investigated the protective effect of rapid eye movement (REM) sleep without atonia against obstructive sleep apnea (OSA) in patients with idiopathic REM sleep behavior disorder (RBD).

Methods: In this case-control study, patients with idiopathic RBD and OSA (RBD-OSA) were consecutively enrolled and OSA controls without RBD were matched for age, sex, and apnea-hypopnea index (AHI). Clinical and polysomnographic characteristics were compared between RBD-OSA patients and OSA controls. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.032DOI Listing
February 2019
1 Read

Response to "prospective memory impairment in idiopathic REM sleep behavior disorder".

Authors:
Xudong Li

Sleep Med 2018 Oct 9. Epub 2018 Oct 9.

Department of Neurology, China-Japan Friendship Hospital, Yinghua East Road, Chaoyang District, Beijing, 100029, China. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2018.09.015DOI Listing
October 2018

High-Order Visual Processing, Visual Symptoms, and Visual Hallucinations: A Possible Symptomatic Progression of Parkinson's Disease.

Front Neurol 2018 27;9:999. Epub 2018 Nov 27.

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

To determine whether Parkinson disease (PD) patients with (VH) have different clinical characteristics and gray-matter volume than those with visual misperceptions (VM) or other visual symptoms (OvS). The spectrum of visual complaints in PD is broad and complex. We conducted a retrospective chart review of 525 PD patients to identify the frequency of visual symptoms and the association with clinical and radiological features. Read More

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http://dx.doi.org/10.3389/fneur.2018.00999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277574PMC
November 2018
1 Read

The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies.

Sleep Med Rev 2019 02 8;43:37-46. Epub 2018 Nov 8.

"Vita-Salute" San Raffaele University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology - Sleep Disorders Centre, Milan, Italy. Electronic address:

Several studies report an association between REM Sleep Behavior Disorder (RBD) and neurodegenerative diseases, in particular synucleinopathies. Interestingly, the onset of RBD precedes the development of neurodegeneration by several years. This review and meta-analysis aims to establish the rate of conversion of RBD into neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/j.smrv.2018.09.008DOI Listing
February 2019
10 Reads

Phenoconversion from Idiopathic Rapid Eye Movement Sleep Behavior Disorder to Lewy Body Disease.

Mov Disord Clin Pract 2018 Sep-Oct;5(5):506-511. Epub 2018 Oct 3.

Center of Sleep Medicine Dokkyo Medical University Hospital Tochigi Japan.

Background: The conversion rate and estimated risk of neurodegenerative diseases vary with idiopathic rapid eye movement sleep behavior disorder (IRBD).

Methods: This retrospective cohort study examined 273 patients (213 men, 60 women) with polysomnographic-confirmed IRBD (192 and 81 patients in the Sleep Center [SC] cohort and Neurological Center [NC] cohort, respectively) who were followed longitudinally. The date of diagnosis was determined as the onset of an overt neurological syndrome. Read More

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http://doi.wiley.com/10.1002/mdc3.12647
Publisher Site
http://dx.doi.org/10.1002/mdc3.12647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207131PMC
October 2018
12 Reads

Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection.

Front Neurol 2018 14;9:961. Epub 2018 Nov 14.

The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.

Sleep contributes to the consolidation of our memory and facilitates learning. Short term sleep deprivation temporarily reduces mnestic capacity, whereas long lasting sleep deprivation is associated with structural changes in the hippocampus and cortical areas. However, it is unknown whether early intervention and treatment of sleep disorders could have a neuroprotective effect. Read More

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http://dx.doi.org/10.3389/fneur.2018.00961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246656PMC
November 2018
1 Read

Sleep-related Eating Disorder in a Patient with Parkinson's Disease.

Cureus 2018 Sep 22;10(9):e3345. Epub 2018 Sep 22.

Neurology, University of Missouri, Columbia, USA.

Sleep disorders constitute a major aspect of the non-motor symptoms of Parkinson's disease (PD). Rapid eye movement (REM) behavior disorders are the most frequently experienced parasomnias in patients with PD. Non-REM sleep disorders like confusional arousals, sleep terrors, sleepwalking, and sleep-related eating disorder (SRED) are also associated with PD. Read More

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http://dx.doi.org/10.7759/cureus.3345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248845PMC
September 2018
9 Reads

Validation of a new data-driven automated algorithm for muscular activity detection in REM sleep behavior disorder.

J Neurosci Methods 2019 Jan 20;312:53-64. Epub 2018 Nov 20.

Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.

Background: Documentation of REM sleep without atonia is fundamental for REM sleep behavior disorder (RBD) diagnosis. The automated REM atonia index (RAI), Frandsen index (FRI) and Kempfner index (KEI) were proposed for this, but achieved moderate performances.

New Method: Using sleep data from 27 healthy controls (C), 29 RBD patients and 36 patients with periodic limb movement disorder (PLMD), we developed and validated a new automated data-driven method for identifying movements in chin and tibialis electromyographic (EMG) signals. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2018.11.016DOI Listing
January 2019
2 Reads

A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep.

J Exp Neurosci 2018 2;12:1179069518808744. Epub 2018 Nov 2.

SLEEP Team, CNRS UMR 5292, INSERM U1028, Centre de Recherche en Neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1, Lyon, France.

Muscle atonia is a major pathognomonic sign of paradoxical sleep (PS; coined REM Sleep), during which dreams mainly occur. In the 1980s, an idiopathic syndrome called REM sleep behavior disorder (RBD) was described in patients endowed with loss of PS paralysis concomitant to abnormal movements, suggesting a dysfunction of PS networks. Another major clinical RBD feature is its prevalent phenoconversion into synucleinopathies as Parkinson's disease in a delay of 10-15 years after diagnosis. Read More

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http://dx.doi.org/10.1177/1179069518808744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236475PMC
November 2018
6 Reads

Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder.

Sleep 2019 Feb;42(2)

Department of Neurology, Seoul National University Hospital, Seoul, South Korea.

Study Objectives: We investigated electroencephalography (EEG) power spectral density and functional connectivity during phasic and tonic rapid eye movement (REM) sleep, and examined any differences between patients with idiopathic REM sleep behavior disorder (iRBD) and controls.

Methods: EEG data from 13 people with iRBD (mean age, 66.3 years; men, 84. Read More

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http://dx.doi.org/10.1093/sleep/zsy227DOI Listing
February 2019
13 Reads

A New Fully Automated Random-Forest Algorithm for Sleep Staging.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:4920-4923

Rapid eye movement (REM) sleep behavior disorder is considered the prodromal stage of alpha-synucleinopathies. Its diagnosis requires careful detection of REM sleep and the gold standard manual sleep staging is inconsistent and expensive. This work proposes a new automatic sleep staging model to add robust automation to such applications, using only electroencephalography (EEG) and electrooculography (EOG) recordings. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8513413DOI Listing
July 2018
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Automating the Detection of REM Sleep Behaviour Disorder.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:1460-1463

This study aims to develop automated diagnostic tools to aid in the identification of rapid-eye-movement (REM) sleep behaviour disorder (RBD). Those diagnosed with RBD enact their dreams and therefore present an abnormal characteristic of movement during REM sleep. Several methods have been proposed for RBD detection that use electromyogram (EMG) recordings and manually annotated sleep stages to objectively quantify abnormal REM movement. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512539DOI Listing
July 2018
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Sleep Posture Classification using a Convolutional Neural Network.

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:1-4

Sleep is a process of rest and renewal that is vital for humans. However, there are several sleep disorders such as rapid eye movement (REM) sleep behaviour disorder (RBD), sleep apnea, and restless leg syndrome (RLS) that can have an impact on a significant portion of the population. These disorders are known to be associated with particular behaviours such as specific body positions and movements. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8513009DOI Listing
July 2018
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Management of Sleep Disturbances in Parkinson's Disease Patients, Carers and the Patient and Carer Dyadic Relationship: A Scoping Review.

Clin Gerontol 2018 Nov 13:1-9. Epub 2018 Nov 13.

a School of Psychology , The University of Queensland , Brisbane , Australia.

Objectives: Sleep disturbances are a debilitating non-motor symptom in Parkinson's disease (PD) and negatively impact patients, their carers and the patient-carer dyadic relationship. This review outlines the phenomenology, as well as factors associated with and treatment of sleep disturbances, in PD patients and their informal carers.

Methods: The following terms were used in four databases: Parkinson*, sleep* disturbance*, carer*, dyad*, intervention* and treatment*. Read More

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http://dx.doi.org/10.1080/07317115.2018.1539424DOI Listing
November 2018
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Vestibular Evoked Myogenic Potentials Are Abnormal in Idiopathic REM Sleep Behavior Disorder.

Front Neurol 2018 29;9:911. Epub 2018 Oct 29.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

To investigate brainstem function in idiopathic REM sleep Behavior Disorder (iRBD), a condition occurring as a result of a derangement of connections within brainstem structures, with a battery of Vestibular Evoked Myogenic Potentials (VEMPs), neurophysiological tools suited for the functional investigation of the brainstem. Neurophysiological data were correlated with clinical characteristics of patients. Twenty patients with iRBD and 22 healthy controls underwent cervical (cVEMP), masseter (mVEMP) and ocular (oVEMP) VEMP recording. Read More

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http://dx.doi.org/10.3389/fneur.2018.00911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215837PMC
October 2018
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Clinical and genetical study of a familial form of REM sleep behavior disorder.

Clin Neurol Neurosurg 2018 Dec 4;175:130-133. Epub 2018 Oct 4.

Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain. Electronic address:

Objective: We report a kindred with a genetic form of REM behaviour disorder (RBD) with autosomal dominant transmission.

Patients And Methods: Clinical, polysomnography study, genetic study and brain MRI were performed to evaluate the index patients. The genetic study included exome sequencing of the index cases that detected 60,869 variants in the individuals examined. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.09.035DOI Listing
December 2018
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Restless Legs Syndrome and Other Movement Disorders of Sleep-Treatment Update.

Curr Treat Options Neurol 2018 Nov 9;20(12):55. Epub 2018 Nov 9.

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

Purpose Of Review: The purpose of this review article is to summarize and discuss the recent advances in the treatment of restless legs syndrome (RLS), as well as REM sleep behavior disorder (RBD), and periodic leg movement disorder (PLMD).

Recent Findings: Traditionally, dopaminergic therapy has been considered the sole option for first-line treatment of RLS due to their impressive acute efficacy. Dopamine agonists such as oral pramipexole and ropinirole, as well as transdermal rotigotine are all effective treatment options. Read More

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http://link.springer.com/10.1007/s11940-018-0540-3
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http://dx.doi.org/10.1007/s11940-018-0540-3DOI Listing
November 2018
16 Reads