1,895 results match your criteria REM Sleep Behavior Disorder


Assessment of cognitive profile as a prodromal marker of the evolution of REM sleep Behavior Disorder.

Sleep 2019 Apr 23. Epub 2019 Apr 23.

Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy.

Study Objectives: To search for a specific neuropsychological profile in idiopathic REM sleep Behavior Disorder (iRBD), able to predict the onset of neurodegenerative disorders.

Methods: In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7± 3. Read More

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http://dx.doi.org/10.1093/sleep/zsz103DOI Listing

, Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches.

Cells 2019 Apr 19;8(4). Epub 2019 Apr 19.

Dino Ferrari Center, Neuroscience Section, Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.

Parkinson's disease (PD) is the second most common degenerative disorder. Although the disease was described more than 200 years ago, its pathogenetic mechanisms have not yet been fully described. In recent years, the discovery of the association between mutations of the gene (encoding for the lysosomal enzyme glucocerebrosidase) and PD facilitated a better understating of this disorder. Read More

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http://dx.doi.org/10.3390/cells8040364DOI Listing

Corticobasal syndrome with visual hallucinations and probable REM-sleep behavior disorder: an autopsied case report of a patient with CBD and LBD pathology.

Neurocase 2019 Apr 22:1-8. Epub 2019 Apr 22.

a Memory and Aging Center, Department of Neurology , University of California San Francisco , San Francisco , CA , USA.

Corticobasal syndrome and dementia with Lewy bodies are clinical presentations with unique and overlapping features but distinct pathological substrates. We report the case of an 80 year-old man who presented with apraxia, rigidity, slowness, right arm myoclonus, a 10-year history of probable REM-sleep behavior disorder, and later developed visual hallucinations. At autopsy, he had pathological features of corticobasal degeneration, and Lewy body disease confined to the brainstem. Read More

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https://www.tandfonline.com/doi/full/10.1080/13554794.2019.1
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http://dx.doi.org/10.1080/13554794.2019.1604973DOI Listing
April 2019
1 Read

Progressive loss of raphe nuclei serotonin transporter in early Parkinson's disease: A longitudinal I-FP-CIT SPECT study.

Parkinsonism Relat Disord 2019 Apr 5. Epub 2019 Apr 5.

Institute of Neuroscience, Newcastle University, UK; Department of Nuclear Medicine & PET Centre, Aarhus University, Denmark. Electronic address:

Background: Serotonergic raphe nuclei dysfunction has been documented in Parkinson's disease, both in pathological and neuroimaging studies, and has been associated with scores of tremor and non-motor symptoms. However, no in vivo longitudinal investigations have been conducted to assess the rate of decline of raphe serotonin transporter availability in the early stages of the disease.

Objective: To measure the rate of decline of raphe serotonin transporter availability over a two-year interval in patients with recently diagnosed disease and its association with non-motor symptoms over time. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.025DOI Listing
April 2019
1 Read

Sleep disorders in NiemannPick disease type C, beyond cataplexy.

Sleep Med 2019 Feb 19;57:122-127. Epub 2019 Feb 19.

Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Brazil; Neurology Service, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil; Center of Health Sciences, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Purpose: The aim of this study was to clinically characterize sleep disorders in a cohort of Niemann-Pick type C (NPC) patients, correlating these findings with disease features and polysomnographic (PSG) results.

Methods: We evaluated eight consecutive patients with molecular confirmation of NPC followed at the Hospital Geral de Fortaleza. Patients underwent a comprehensive neurological and sleep evaluation. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.02.007DOI Listing
February 2019
2 Reads

CSF1R mutation presenting as dementia with Lewy bodies.

Neurocase 2019 Apr 10:1-4. Epub 2019 Apr 10.

a Department of Neurology , Mayo Clinic , Rochester , MN , USA.

Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an adult-onset autosomal dominant leukoencephalopathy resulting from mutations affecting the tyrosine kinase domain of the colony stimulating factor receptor 1 protein (encoded by CSF1R). The clinical phenotypes reported with CSF1R mutations are variable. We present a case of a patient with a pathogenic variant in the CSF1R gene with clinical and imaging features suggestive of Dementia with Lewy Bodies (DLB). Read More

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http://dx.doi.org/10.1080/13554794.2019.1601230DOI Listing
April 2019
1 Read

The impact of central and obstructive respiratory events on cerebral oxygenation in children with sleep disordered breathing.

Sleep 2019 Feb 20. Epub 2019 Feb 20.

The Ritchie Centre, Hudson Institute of Medical Research, Department of Paediatrics, Monash University, Melbourne, Australia.

Study Objectives: Both central and obstructive respiratory events are features of sleep disordered breathing. The repetitive hypoxia associated with obstructive events is believed to underpin the adverse neurocognitive and cardiovascular sequelae of this disorder, however whether central events contribute to this has not been investigated. To compare changes in cerebral and peripheral oxygenation, blood pressure and heart rate, associated with central and obstructive events in children aged 3-6 and 7-12 years. Read More

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http://dx.doi.org/10.1093/sleep/zsz044DOI Listing
February 2019
3 Reads

APOE ɛ4 and REM Sleep Behavior Disorder as Risk Factors for Sundown Syndrome in Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.

Background: Sundown syndrome (SS) in patients with Alzheimer's disease (AD) is characterized by aggravation of behavioral problems at sunset. Disturbance of the circadian rhythm, a possible cause of SS, also facilitates amyloidopathy and reduces sleep quality. However, the associations of SS with amyloidopathy and sleep quality remain unclear. Read More

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http://dx.doi.org/10.3233/JAD-190032DOI Listing
April 2019
2 Reads

Impulse Control Disorders in REM Sleep Behavior Disorder.

Curr Treat Options Neurol 2019 Apr 8;21(5):23. Epub 2019 Apr 8.

EA 7280 Laboratory of Neuropychopharmacology of the Subcortical Dopaminergic Systems, UFR Medecine, Université Clermont Auvergne, Clermont-Ferrand, France.

Purpose Of Review: This paper reviews clinical and pathophysiological features of both impulse control disorders (ICDs) and REM sleep behavior disorder (RBD) in Parkinson's disease (PD), as well as current evidences of their association. Then, we suggest recommendations to manage PD patients with RBD in order to prevent this potentially devastating psychiatric complication.

Recent Findings: ICDs are psychiatric complications occurring in patients with Parkinson's disease (PD) treated with dopaminergic replacement therapies (DRT). Read More

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http://dx.doi.org/10.1007/s11940-019-0564-3DOI Listing
April 2019
1 Read

[Abnormal functional connectivity between sublaterodorsal nucleus and the motor cortex in Parkinson's disease with rapid-eye-movement sleep behavior disorder].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(13):993-997

Department of Neurology, the People's Hospital of Zhengzhou University, Zhengzhou 450003, China.

To investigate the abnormal functional connectivity between sublaterodorsal nucleus (SLD) and the brain motor areas in Parkinson's disease with or without rapid-eye-movement (REM) sleep behavior disorder by resting state functional magnetic resonance imaging (rfMRI). A total of 64 subjects recruited in the Department of Neurology, the People's Hospital of Zhengzhou University were enrolled in this study from August 2014 to December 2017 according to international diagnosis criteria, 20 cases with PD-RBD (PD-RBD group), 23 cases without PD-nRBD (PD-nRBD group) and 21 age, gender-matched healthy controls (HC group). All subjects were examined by Hoehn-Yahr, UPDRS-Ⅲ and rfMRI. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.13.007DOI Listing
April 2019
2 Reads

Parasomnia overlap disorder with adolescent-onset presumed REM sleep behavior disorder converting to Parkinson's disease after 48 years.

Sleep Med 2019 Feb 12;57:97-99. Epub 2019 Feb 12.

Newcastle Regional Sleep Service, Freeman Hospital, Newcastle upon Tyne, UK; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Background: It is now recognized that the vast majority of individuals with typical RBD will develop a synucleinopathy; usually 11-16 years after symptom onset. Parasomnia Overlap Disorder (POD) with adolescent-onset dream enactment behavior with phenoconversion to neurodegenerative disease after a long latency has not been previously described.

Patient: We present a case of a 65-year-old man with presumptive POD who had co-morbid childhood onset sleep walking and adolescent-onset dream enactment behavior beginning at age 17, with subsequent evolution to an increasingly troublesome REM sleep behavior disorder (RBD) at age 64 with Parkinson's Disease (PD) developing a year later. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.041DOI Listing
February 2019
1 Read
3.154 Impact Factor

Relationship between Lower Urinary Tract Dysfunction and Clinical Features in Chinese Parkinson's Disease Patients.

Parkinsons Dis 2019 5;2019:6820937. Epub 2019 Mar 5.

Department of Neurology, Shengjing Hospital, Affiliated Hospital of China Medical University, No. 36 Sanhao Street, Shen Yang 110004, China.

Background: Lower urinary tract (LUT) dysfunction is very common in Parkinson's disease (PD) patients. However, the number of studies conducted on LUT dysfunction and its related factors in Chinese PD patients is very limited, and there is no international consensus concerning the results.

Methods: This cross-sectional study enrolled 100 Chinese PD patients. Read More

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http://dx.doi.org/10.1155/2019/6820937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425341PMC
March 2019
3 Reads

Clinical and Video-Polysomnographic Analysis of Rem Sleep Behavior Disorder and other Sleep Disturbances in Dementia with Lewy Bodies.

Sleep 2019 Apr 4. Epub 2019 Apr 4.

Neurology Service, Multidisciplinary Sleep Unit, Universitat de Barcelona, IDIBAPS, CIBERNED, Hospital Clinic de Barcelona, Spain.

Objective: To study REM sleep behavior disorder (RBD) and other sleep disorders in dementia with Lewy bodies (DLB).

Methods: Consecutive patients with DLB and mild dementia severity were recruited irrespective of sleep complaints. Patients underwent clinical interview, assessment of sleep scales and video-polysomnography. Read More

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http://dx.doi.org/10.1093/sleep/zsz086DOI Listing
April 2019
5 Reads

[A case of severe obstructive sleep apnea mimicking REM sleep behavior disorder].

Rinsho Shinkeigaku 2019 Mar 30. Epub 2019 Mar 30.

Sleep Medical Center, Osaka Kaisei Hospital.

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http://dx.doi.org/10.5692/clinicalneurol.cn-001230DOI Listing
March 2019
4 Reads

Cerebral glucose metabolism in idiopathic REM sleep behavior disorder is different from tau-related and α-synuclein-related neurodegenerative disorders: A brain [18F]FDG PET study.

Parkinsonism Relat Disord 2019 Mar 23. Epub 2019 Mar 23.

Sleep Medicine Centre, Department of Systems Medicine, University of Rome 'Tor Vergata", Rome, Italy.

Introduction: Several longitudinal studies revealed that patients affected by idiopathic REM behavior disorder (iRBD) trend to convert to α-synucleinopathies at follow-up, although the time and direction of conversion is currently unpredictable. This study aimed at evaluating brain glucose metabolism, measured by [18F]FDG-PET, in patients affected by iRBD and compared to Parkinson's Disease (PD), Lewy Body Dementia (DLB), Alzheimer's Disease (AD), and controls.

Methods: Differences in brain [18F]FDG uptake were analyzed using statistical parametric mapping implemented in Matlab R2012b among iRBD, PD, DLB, AD, and controls. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.017DOI Listing
March 2019
2 Reads

Prodromal Parkinson's Disease: The Decade Past, the Decade to Come.

Mov Disord 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.

The past decade has seen a dramatic expansion of the field of prodromal PD. Ten years ago, there were only six known prodromal markers of disease, none of which had more than two studies documenting diagnostic value. We now have at least 16 markers, with as many as 10 prospective studies for a single marker. Read More

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http://dx.doi.org/10.1002/mds.27670DOI Listing
March 2019
1 Read

Parkinsonism Risk Factors in Salt Lake City, Utah: A Community-Based Study.

Brain Sci 2019 Mar 23;9(3). Epub 2019 Mar 23.

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Background: The prevalence of dream enactment behavior and other risk factors for a parkinsonian disorder is not well documented.

Methods: A survey on prevalence of parkinsonism risk factors was designed using two validated instruments (REM behavior disorder single item question, bowel movement frequency for constipation) and three exploratory instruments (for hallucinations, cognitive and olfactory complaints.) It was sent by mail and email to patients aged 50 and over at two University of Utah community clinics in Salt Lake City. Read More

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http://dx.doi.org/10.3390/brainsci9030071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468352PMC
March 2019
2 Reads

A case report of REM sleep behavior disorder, Behcet's disease, Sjogren's syndrome and cognitive dysfunction.

BMC Rheumatol 2018 2;2:19. Epub 2018 Jul 2.

1Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044 People's Republic of China.

Background: Behcet's disease and Sjogren's syndrome is an autoimmune disorder from which many systems of the body can suffer. Here we reported a patient with a history of Behcet's disease and Sjogren's syndrome in which REM sleep behavior disorder (RBD) was then detected by polysomnographic (PSG) monitoring.

Case Presentation: A 68-year-old male patient with a history of Behcet's disease and Sjogren's syndrome was diagnosed with RBD by clinical examination and video-PSG, and he also underwent a multiple sleep latency test and cerebral magnetic resonance imaging. Read More

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http://dx.doi.org/10.1186/s41927-018-0022-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390777PMC
July 2018
11 Reads

A New Metabolic Network Correlated with Olfactory and Executive Dysfunctions in Idiopathic Rapid Eye Movement Sleep Behavior Disorder.

J Clin Neurol 2019 Apr 11;15(2):175-183. Epub 2019 Mar 11.

Department of Nuclear Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

Background And Purpose: To identify a metabolic network reflecting neurodegeneration in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).

Methods: We recruited a prospective cohort comprising patients with Parkinson's disease (PD) with probable REM sleep behavior disorder (PDRBD, =21), polysomnography-confirmed iRBD patients (=28), and age-matched healthy controls (HC) (=24). PDRBD-related spatial covariance pattern (PDRBD-RP) were determined from ¹⁸F-fluorodeoxyglucose PET images of the PDRBD group and validated by reproduction in a separate PD cohort with polysomnography-confirmed REM sleep behavior disorder (=11). Read More

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http://dx.doi.org/10.3988/jcn.2019.15.2.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444138PMC
April 2019
1 Read

Parasomnias: A Comprehensive Review.

Cureus 2018 Dec 31;10(12):e3807. Epub 2018 Dec 31.

Pulmonary Medicine, Marshall University School of Medicine, Huntington, USA.

Parasomnias are a group of sleep disorders characterized by abnormal, unpleasant motor verbal or behavioral events that occur during sleep or wake to sleep transitions. Parasomnias can occur during non-rapid eye movement (NREM) and rapid eye movement (REM) stages of sleep and are more commonly seen in children than the adult population. Parasomnias can be distressful for the patient and their bed partners and most of the time, these complaints are brought up by their bed partners because of the possible disruption in their quality of sleep. Read More

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https://www.cureus.com/articles/16963-parasomnias-a-comprehe
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http://dx.doi.org/10.7759/cureus.3807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402728PMC
December 2018
10 Reads

Brain atrophy in Parkinson's disease with polysomnography-confirmed REM sleep behavior disorder.

Sleep 2019 Mar 7. Epub 2019 Mar 7.

Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Canada.

We aimed to investigate cortical and subcortical brain alterations in Parkinson's disease patients with polysomnography-confirmed REM sleep behavior disorder (RBD). Thirty Parkinson's disease patients, including 15 patients with RBD, were recruited and compared to 41 healthy controls. Surface-based cortical and subcortical analyses were performed on T1-weighted images to investigate thickness and shape abnormalities between groups, and voxel-based and deformation-based morphometry were performed to investigate local volume. Read More

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http://dx.doi.org/10.1093/sleep/zsz062DOI Listing
March 2019
2 Reads
4.591 Impact Factor

Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.

Sleep Med 2019 Jan 28. Epub 2019 Jan 28.

Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

Objectives: To investigate whether baseline electromyography (EMG) activity during rapid eye movement (REM) sleep predicts the development of neurodegenerative diseases over time in patients with idiopathic REM sleep behavior disorder (iRBD).

Methods: A total of 216 patients with polysomnography-confirmed iRBD were recruited from September 1997 to December 2016 with a mean follow-up duration of 5.0 ± 3. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.018DOI Listing
January 2019
2 Reads

Clinical features of freezing of gait in Parkinson's disease patients.

Brain Behav 2019 Apr 9;9(4):e01244. Epub 2019 Mar 9.

National Hospital Organization Matsue Medical Center, Matue, Japan.

Objective: To clarify the clinical features of freezing of gait (FOG) in Parkinson's disease (PD) patients by classification into two groups: Clinically observed FOG (CFOG) and self-reported FOG (SFOG).

Methods: Two hundred twenty-nine PD patients were medically examined in an examination room as well as subjected to a New Freezing of Gait Questionnaire (NFOG-Q) and analysis of nonmotor symptoms including sleep, cognition, depression, and fatigue.

Results: The prevalence of CFOG was 17. Read More

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http://dx.doi.org/10.1002/brb3.1244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456785PMC
April 2019
10 Reads

Clinical progression in Parkinson's disease with features of REM sleep behavior disorder: A population-based longitudinal study.

Parkinsonism Relat Disord 2019 Jan 29. Epub 2019 Jan 29.

Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address:

Introduction: Rapid Eye Movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment and is associated with incidence of neurodegenerative disorders, especially Parkinson's disease (PD). Whether PD with RBD constitutes a distinct subtype with unique progression is unknown. Here, we investigated motor and cognitive symptom progression in patients with self-reported RBD features in adult life. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.018DOI Listing
January 2019
8 Reads

Apathy in Parkinson's disease with REM sleep behavior disorder.

J Neurol Sci 2019 Apr 20;399:194-198. Epub 2019 Feb 20.

Sleep-Wake-Epilepsy Center, Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.

Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) in patients with Parkinson's disease (PD) is associated with increased risk of non-motor symptoms. However, the association between RBD and apathy in PD remains unclear.

Aims: To compare the prevalence and severity of apathy symptoms in PD patients with RBD (PD-RBD+) and without (PD-RBD-). Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.028DOI Listing
April 2019
1 Read

REM sleep behaviour disorder: an early window for prevention in neurodegeneration?

Brain 2019 Mar;142(3):498-501

UCL Movement Disorders Centre, UCL Queen Square Institute of Neurology, UK.

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http://dx.doi.org/10.1093/brain/awz014DOI Listing
March 2019
6 Reads

Diffuse Lewy body disease.

J Neurol Sci 2019 Apr 20;399:144-150. Epub 2019 Feb 20.

The Truong Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA; Departments of Psychiatry and Neuroscience, UC Riverside, Riverside, CA, USA. Electronic address:

Diffuse Lewy body disease, also called dementia with Lewy bodies (DLB), is defined as progressive dementia and pathological Lewy bodies distributed in the central and autonomic nervous systems. The clinical features are dementia, cognitive fluctuations, visual hallucinations, parkinsonism, and REM sleep behavior disorder (RBD). Confirmatory techniques include dopamine transporter imaging, meta-iodobenzylguanidine (MIBG) myocardial scintigraphy, and polysomnography. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.021DOI Listing

Sleep-related disorders and their relationship with MRI findings in multiple sclerosis.

Sleep Med 2019 Jan 21. Epub 2019 Jan 21.

IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences and Università Vita-Salute San Raffaele, Milan, Italy. Electronic address:

Sleep-related disorders have been reported to have a higher prevalence in multiple sclerosis (MS) than in the general population. They are often undervalued for the presence of more severe physical problems and the occurrence at night, without a direct observation in common clinical practice, but if not recognized and treated they can negatively affect the quality of life causing daytime drowsiness and worsening fatigue. Sleep related disorders most commonly reported in MS are as follows: insomnia, sleep-related breathing disorders (SRBD), restless legs syndrome (RLS) and periodic limb movement disorders (PLMD). Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.010DOI Listing
January 2019
15 Reads

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study.

Brain 2019 Mar;142(3):744-759

Department of Neurology, McGill University, Montreal General Hospital, Montreal, Canada.

Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, and potentially intervene with neuroprotective therapy. For future neuroprotective trials, it is essential to accurately estimate phenoconversion rate and identify potential predictors of phenoconversion. Read More

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http://dx.doi.org/10.1093/brain/awz030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391615PMC
March 2019
3 Reads

The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 04 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
April 2019
2 Reads

Detection of REM sleep behaviour disorder by automated polysomnography analysis.

Clin Neurophysiol 2019 Apr 6;130(4):505-514. Epub 2019 Feb 6.

University of Oxford, Institute of Biomedical Engineering, Dept. Engineering Sciences, Oxford, UK.

Objective: Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification.

Methods: Analysis was assessed using a limited polysomnography montage from 53 participants with RBD and 53 age-matched healthy controls. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.011DOI Listing
April 2019
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Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies.

Sleep Med 2019 Mar 18;55:62-68. Epub 2018 Dec 18.

Department of Neurology, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal; CEDOC, Chronic Diseases Research Center, NOVA Medical School, USA.

Introduction: Sleep dysfunction is frequent in Dementia with Lewy Bodies (DLB), but polysomnographic (PSG) data is scarce. Our objectives were to: (1) compare PSG data between DLB patients and age normative values (NV), Parkinson's Disease (PD) and idiopathic REM sleep behavior disorder (iRBD) patients; (2) evaluate the relation between of OSA, Fluctuations and Hypersomnolence and PSG data.

Methods: We selected all consecutive patients with DLB, PD and iRBD that underwent video-PSG during a two year period. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.006DOI Listing
March 2019
6 Reads

Nightmare disorder and REM sleep behavior disorder in inflammatory arthritis: Possibility beyond neurodegeneration.

Brain Behav 2019 Mar 15;9(3):e01230. Epub 2019 Feb 15.

Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.

Objectives: To investigate the prevalence of REM sleep behavior disorder (RBD) in patients with inflammatory arthritis (IA) to ascertain if RBD could be an internal red flag signaling a fluctuating state of inflammation based on the theory of "protoconsciousness".

Materials & Methods: One hundred and three patients with a confirmed diagnosis of IA were consecutively recruited. The patients underwent general (IA activity, functional status, laboratory tests) and neurological evaluations. Read More

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http://dx.doi.org/10.1002/brb3.1230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422707PMC
March 2019
4 Reads

Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.

Eur J Neurol 2019 Feb 15. Epub 2019 Feb 15.

Philipps University, Marburg, Germany.

Background: Visualization of phosphorylated α-synuclein at serine 129 (p-syn) in skin nerves is a promising test for the in vivo diagnosis of synucleinopathies. Here we aimed to establish the intra- and inter-laboratory reproducibility of quantification of intraneural p-syn immunoreactivity in two laboratories with a major expertise (Würzburg and Bologna).

Methods: We enrolled 43 patients affected by Parkinson's disease (PD: 21 patients), Dementia with Lewy Body (DLB: 1), REM sleep behavior disorder (RBD: 11), Multiple System Atrophy (MSA-P: 4) and small fiber neuropathy (SFN: 6). Read More

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http://dx.doi.org/10.1111/ene.13939DOI Listing
February 2019
1 Read

MIBG Myocardial Scintigraphy Identifies Premotor PD/DLB During a Negative DAT Scan Period: Second Report.

Mov Disord Clin Pract 2019 Jan 9;6(1):46-50. Epub 2018 Nov 9.

Gastroenterology, Internal Medicine, Sakura Medical Center Toho University Sakura Japan.

Objectives: Neuroimaging markers for Parkinson's disease (PD)/dementia with Lewy bodies (DLB) include dopamine transporter (DAT) scanning and metaiodobenzylguanidine (MIBG) myocardial scintigraphy. It is unknown which marker is useful to identify the premotor phase PD/DLB. We reported four patients who, during a negative DAT scan period, had a positive MIBG result that suggested premotor PD/DLB. Read More

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http://dx.doi.org/10.1002/mdc3.12697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335543PMC
January 2019
3 Reads

Long Lag Between Drug-induced Parkinsonism and Idiopathic Parkinson's Disease in Idiopathic REM Sleep Behavior Disorder.

Mov Disord Clin Pract 2018 Mar-Apr;5(2):203-205. Epub 2018 Jan 10.

Department of Neurology and Neurosurgery McGill University Montreal Quebec Canada.

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http://dx.doi.org/10.1002/mdc3.12576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336185PMC
January 2018
2 Reads

Brain Glucose Metabolism Heterogeneity in Idiopathic REM Sleep Behavior Disorder and in Parkinson's Disease.

J Parkinsons Dis 2019 ;9(1):229-239

Institutes of Cognitive Sciences and Technologies, CNR, Rome, Italy.

Background/objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function.

Methods: Thirty-six iRBD patients (64. Read More

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http://dx.doi.org/10.3233/JPD-181468DOI Listing
January 2019
2 Reads

Sleep disturbances are common in patients with autoimmune encephalitis.

J Neurol 2019 Apr 11;266(4):1007-1015. Epub 2019 Feb 11.

Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.

Objectives: Autoimmune encephalitis (AE) is increasingly recognized as an important cause of subacute cognitive decline, seizures, and encephalopathy, with an ever-broadening clinical phenotype. Sleep disturbances are reported in AE patients, including rapid eye movement sleep behavior disorder, hypersomnia, fragmented sleep, and sleep-disordered breathing; however, the prevalence of sleep disturbances and contributions to outcomes in AE patients remain unknown. There is a need to determine the prevalence of sleep disturbances in AE patients, and to clarify the relationship between specific autoantibodies and disruptions in sleep. Read More

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http://dx.doi.org/10.1007/s00415-019-09230-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421090PMC
April 2019
6 Reads

Correlations between dopaminergic dysfunction and abnormal metabolic network activity in REM sleep behavior disorder.

J Cereb Blood Flow Metab 2019 Feb 10:271678X19828916. Epub 2019 Feb 10.

1 PET Center, Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Striatal dopamine transporter (DAT) deficiency and abnormal expression of Parkinson's disease (PD)-related pattern (PDRP) have been observed in patients with idiopathic REM sleep behavior disorder (IRBD). This study aimed to investigate the correlations between these two measures with comparison to PD using a dual tracer imaging design. Age-matched 37 IRBD patients, 86 PD patients, and 15 control subjects underwent concurrent PET scans with C-CFT to quantify dopaminergic dysfunction and F-FDG to quantify PDRP expression. Read More

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http://dx.doi.org/10.1177/0271678X19828916DOI Listing
February 2019
4 Reads

Trauma-Associated Sleep Disorder: A Posttraumatic Stress/REM Sleep Behavior Disorder Mash-Up?

J Clin Sleep Med 2019 Feb 15;15(2):345-349. Epub 2019 Feb 15.

Mayo Center for Sleep Medicine, Departments of Neurology and Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota.

Abstract: Trauma-associated sleep disorder (TASD) is a parasomnia sharing characteristics of post-traumatic stress disorder (PTSD) and REM sleep behavior disorder (RBD) including dream-enactment behavior (DEB). Here we report REM sleep without atonia (RSWA) and other neurological features in a patient with complex vocal and motor DEB following traumatic combat military exposure. Post-discharge, his wife observed frequent yelling and jerking during sleep with dream mentation reminiscent of traumatic military experiences. Read More

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http://dx.doi.org/10.5664/jcsm.7642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374091PMC
February 2019
3 Reads

Abnormal nocturnal behavior due to hypoglycemia: A case report.

Medicine (Baltimore) 2019 Feb;98(6):e14405

Department of Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai.

Rationale: Hypoglycemia, which is characterized mainly by palpitations, dizziness, and sweating, is common and easy to identify. However, some other symptoms, such as mental disorder or abnormal behavior, are atypical, which may lead to a misdiagnosis of epilepsy, sleepwalking, infarction, or mental disorder, among others.

Patient Concerns: We report a case of a patient with type 2 diabetes who presented with abnormal nocturnal behavior due to hypoglycemia. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902080-0007
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http://dx.doi.org/10.1097/MD.0000000000014405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380808PMC
February 2019
9 Reads

Newly Identified Sleep-Wake and Circadian Circuits as Potential Therapeutic Targets.

Sleep 2019 Feb 5. Epub 2019 Feb 5.

epartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, NeuroNexus Institute, Graduate Program in Neuroscience - Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA.

Optogenetics and chemogenetics are powerful tools, allowing the specific activation or inhibition of targeted neuronal sub-populations. Application of these techniques to sleep and circadian research has resulted in the unveiling of several neuronal populations that are involved in sleep-wake control, and allowed a comprehensive interrogation of the circuitry through which these nodes are coordinated to orchestrate the sleep-wake cycle. In this review, we discuss six recently described sleep-wake and circadian circuits that show promise as therapeutic targets for sleep medicine. Read More

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http://dx.doi.org/10.1093/sleep/zsz023DOI Listing
February 2019
7 Reads

Imaging in prodromal dementia with Lewy bodies: Where do we stand?

Int J Geriatr Psychiatry 2019 May 15;34(5):635-646. Epub 2019 Mar 15.

Campus for Ageing and Vitality, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Objectives: The aim of this review was to provide an overview of the literature on imaging in prodromal dementia with Lewy bodies (DLB).

Design: Systematic PubMed search and literature review.

Results: Diagnostic classification of the prodromal DLB stage remains to be established but is likely to require imaging biomarkers to improve diagnostic accuracy. Read More

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http://doi.wiley.com/10.1002/gps.5071
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http://dx.doi.org/10.1002/gps.5071DOI Listing
May 2019
13 Reads

Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder.

NPJ Parkinsons Dis 2019 29;5. Epub 2019 Jan 29.

15Department of Neurology, Philipps University, Marburg, Germany.

REM sleep behavior disorder (RBD) is strongly associated with development of Parkinson's Disease and other α-synuclein-related disorders. Dopamine transporter (DAT) binding deficit predicts conversion to α-synuclein-related disorders in individuals with RBD. In turn, identifying which individuals with RBD have the highest likelihood of having abnormal DAT binding would be useful. Read More

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http://dx.doi.org/10.1038/s41531-018-0073-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351563PMC
January 2019
1 Read

Young-Onset Dementia with Lewy Bodies.

Case Rep Neurol 2018 Sep-Dec;10(3):363-368. Epub 2018 Dec 20.

Radiology, Sakura Medical Center, Toho University, Sakura, Japan.

Young-onset (< 65 years) dementia is a challenging clinical problem. A 61-year-old man visited our clinic because of a 2-year history of mild cognitive impairment of the executive disorder type. He was initially suspected of having young-onset Alzheimer's disease due to the lack of motor signs or hippocampal atrophy by conventional brain MRI. Read More

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http://dx.doi.org/10.1159/000495748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341340PMC
December 2018
9 Reads

Diagnostic Criteria, Differential Diagnosis, and Treatment of Minor Motor Activity and Less Well-Known Movement Disorders of Sleep.

Curr Treat Options Neurol 2019 Jan 19;21(1). Epub 2019 Jan 19.

Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Purpose Of Review: Sleep-related movement disorders (SRMD) include several different motor activities during sleep. Few of them are well known and well classified, whereas others are minor motor disorders of sleep which are neither thoroughly characterized and classified nor have been extensively investigated to clarify their pathogenesis and clinical relevance. This review will focus on those minor sleep-related movement disorders. Read More

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http://dx.doi.org/10.1007/s11940-019-0543-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339673PMC
January 2019
3 Reads

Trauma-Associated Sleep Disturbances: a Distinct Sleep Disorder?

Curr Sleep Med Rep 2018 Jun 26;4(2):143-148. Epub 2018 Apr 26.

VA Portland Health Care System.

Purpose Of Review: This paper describes a newly proposed sleep disorder, trauma-associated sleep disorder (TSD). Whether or not this represents a truly unique condition is controversial. In this paper, we describe the overlapping features and differences between TSD, post-traumatic stress disorder (PTSD) and Rapid Eye Movement (REM) sleep behavior disorder (RBD). Read More

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http://link.springer.com/10.1007/s40675-018-0119-2
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http://dx.doi.org/10.1007/s40675-018-0119-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330699PMC
June 2018
8 Reads

CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.

Curr Neurol Neurosci Rep 2019 Jan 14;19(2). Epub 2019 Jan 14.

Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy.

Purpose Of Review: Idiopathic REM sleep behavior disorder (iRBD) is one of the most significant prodromal manifestations of synucleinopathies. Different predictive biomarkers for iRBD conversion have been investigated, but scarce data are present in literature about the predictive role of cerebrospinal fluid (CSF) biomarkers. In this review, we focus on CSF biomarkers in patients with both iRBD and RBD associated with synucleinopathies to explore their potential predictive power. Read More

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http://link.springer.com/10.1007/s11910-019-0918-y
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http://dx.doi.org/10.1007/s11910-019-0918-yDOI Listing
January 2019
19 Reads

Spinocerebellar ataxia type 31 associated with REM sleep behavior disorder: a case report.

BMC Neurol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Neurology, University of Yamanashi, 1110 Shimokatou, Yamanashi, 409-3898, Japan.

Background: Spinocerebellar ataxia type 31 (SCA 31) is a slowly progressive neurodegenerative disorder characterized by pure cerebellar ataxia. Unlike other CAG repeat diseases, sleep-related problems have not been reported in patients with SCA 31 so far.

Case Presentation: A 67-year-old woman was admitted to our hospital with dysarthria and gait disturbance after onset age of 62 years. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1238-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329112PMC
January 2019
16 Reads