1,636 results match your criteria Quality Control Metrics


MaxQuant.Live enables global targeting of more than 25,000 peptides.

Mol Cell Proteomics 2019 Feb 12. Epub 2019 Feb 12.

Dept. Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Germany

Mass spectrometry (MS)-based proteomics is often performed in a shotgun format, in which as many peptide precursors as possible are selected from full or MS1 scans so that their fragment spectra can be recorded in MS2 scans. While achieving great proteome depths, shotgun proteomics cannot guarantee that each precursor will be fragmented in each run. In contrast, targeted proteomics aims to reproducibly and sensitively record a restricted number of precursor/fragment combinations in each run, based on pre-scheduled mass-to-charge and retention time windows. Read More

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http://dx.doi.org/10.1074/mcp.TIR118.001131DOI Listing
February 2019

Practical application of the sigma-metric run size nomogram for multistage bracketed statistical quality control analysis of eight enzymes.

Clin Chim Acta 2019 Feb 8;492:57-61. Epub 2019 Feb 8.

Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Background: A sigma-metric run size nomogram is used to recommend quality control (QC) strategies to reduce patient risks. Herein, we aimed to evaluate the sigma performance of 8 enzymes and apply multistage bracketed statistical QC (SQC).

Methods: Sigma performance of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), amylase (AMY), and lipase (LIP) were determined. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.006DOI Listing
February 2019
1 Read

Exposure-complaint relationships of various environmental odor sources in Styria, Austria.

Environ Sci Pollut Res Int 2019 Feb 8. Epub 2019 Feb 8.

Air Quality Control, Government of Styria, Landhausgasse 7, 8010, Graz, Austria.

In the planning and authorization process of industrial plants or agricultural buildings, it needs to be ensured that odor emissions do not annoy nearby residents in an unacceptable way. Previous studies have shown that odor-hour frequency is an important predictor for odor annoyance. However, odor-hour frequencies can be assessed for day and night separately. Read More

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http://link.springer.com/10.1007/s11356-019-04410-z
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http://dx.doi.org/10.1007/s11356-019-04410-zDOI Listing
February 2019
4 Reads

Hospital palliative care consult improves value-based purchasing outcomes in a propensity score-matched cohort.

Palliat Med 2019 Feb 7:269216318824270. Epub 2019 Feb 7.

1 Department of Internal Medicine, Christiana Care Health System, Newark, DE, USA.

Background:: Hospital-based palliative care consultation is consistently associated with reduced hospitalization costs and more importantly with improved patient quality of life. As healthcare systems move toward value-based purchasing rather than fee-for-service models, understanding how palliative care consultation is associated with value-based purchasing metrics can provide evidence for expanded health system support for a greater palliative care presence.

Aim:: To understand how a palliative care consultation impacts rates of patient readmission and hospital-acquired infections associated with value-based purchasing metrics. Read More

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http://dx.doi.org/10.1177/0269216318824270DOI Listing
February 2019
1 Read

Baseline mental status predicts happy patients after operative or non-operative treatment of adult spinal deformity.

J Spine Surg 2018 Dec;4(4):687-695

Department of Orthopaedic Surgery, NYU Langone Orthopaedic Hospital-New York Spine Institute, New York, NY, USA.

Background: The study is a retrospective review of a multi-institutional database, aiming to determine predictors of non-depressed, satisfied adult spinal deformity (ASD) patients with good self-image at 2-year follow-up (2Y). ASD significantly impacts a patients' psychological status. Following treatment, little is known about predictors of satisfied patients with high self-image and mental status. Read More

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http://dx.doi.org/10.21037/jss.2018.09.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330579PMC
December 2018
1 Read

Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda.

Gates Open Res 2018 Nov 13;2:32. Epub 2018 Nov 13.

RTI International, Washington DC, USA.

Heterogeneity in malaria transmission has household, temporal, and spatial components. These factors are relevant for improving the efficiency of malaria control by targeting heterogeneity. To quantify variation, we analyzed mosquito counts from entomological surveillance conducted at three study sites in Uganda that varied in malaria transmission intensity. Read More

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https://gatesopenresearch.org/articles/2-32/v2
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http://dx.doi.org/10.12688/gatesopenres.12838.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350504PMC
November 2018
7 Reads

Commissioning of a fluoroscopic-based real-time markerless tumor tracking system in a superconducting rotating gantry for carbon-ion pencil beam scanning treatment.

Med Phys 2019 Jan 28. Epub 2019 Jan 28.

Toshiba Energy System & Solutions Corporation, Kanagawa, 212-8585, Japan.

Purpose: To perform the final quality assurance of our fluoroscopic-based markerless tumor tracking for gated carbon-ion pencil beam scanning (C-PBS) radiotherapy using a rotating gantry system, we evaluated the geometrical accuracy and tumor tracking accuracy using a moving chest phantom with simulated respiration.

Methods: The positions of the dynamic flat panel detector (DFPD) and X-ray tube are subject to changes due to gantry sag. To compensate for this, we generated a geometrical calibration table (gantry flex map) in 15° gantry angle steps by the bundle adjustment method. Read More

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http://dx.doi.org/10.1002/mp.13403DOI Listing
January 2019
1 Read

Ambient ozone and fine particulate matter exposures and autism spectrum disorder in metropolitan Cincinnati, Ohio.

Environ Res 2019 Jan 10;171:218-227. Epub 2019 Jan 10.

Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, United States.

Background: Epidemiological studies report fairly consistent associations between various air pollution metrics and autism spectrum disorder (ASD), with some elevated risks reported for different prenatal and postnatal periods.

Objectives: To examine associations between ASD and ambient fine particulate matter (PM) and ozone concentrations during the prenatal period through the second year of life in a case-control study.

Methods: ASD cases (n = 428) diagnosed at Cincinnati Children's Hospital Medical Center were frequency matched (15:1) to 6420 controls from Ohio birth records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351193001
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http://dx.doi.org/10.1016/j.envres.2019.01.013DOI Listing
January 2019
6 Reads

The emergence of antimicrobial resistance in environmental strains of the Bacteroides fragilis group.

Environ Int 2019 Mar 22;124:408-419. Epub 2019 Jan 22.

Department of Environmental Microbiology, University of Warmia and Mazury in Olsztyn, Prawocheńskiego 1, 10-957 Olsztyn, Poland. Electronic address:

Anaerobic bacteria of the genus Bacteroides are a large group of commensal microorganisms that colonize the human and animal digestive tract. The genus Bacteroides and the closely related genus Parabacteroides include the Bacteroides fragilis group (BFG) of potentially pathogenic bacteria which are frequently isolated from patients with anaerobic infections. The aim of this study was to assess the antimicrobial resistance of environmental strains of the Bacteroides fragilis group. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.056DOI Listing
March 2019
1 Read

Spatiotemporal quantification of acoustic cell patterning using Voronoï tessellation.

Lab Chip 2019 Feb;19(4):562-573

Department of Materials, Department of Bioengineering, and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.

Acoustic patterning using ultrasound standing waves has recently emerged as a potent biotechnology enabling the remote generation of ordered cell systems. This capability has opened up exciting opportunities, for example, in guiding the development of organoid cultures or the organization of complex tissues. The success of these studies is often contingent on the formation of tightly-packed and uniform cell arrays; however, a number of factors can act to disrupt or prevent acoustic patterning. Read More

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http://dx.doi.org/10.1039/c8lc01108gDOI Listing
February 2019
2 Reads

Measuring the Impact of an Open Web-Based Prescribing Data Analysis Service on Clinical Practice: Cohort Study on NHS England Data.

J Med Internet Res 2019 Jan 16;21(1):e10929. Epub 2019 Jan 16.

Evidence Based Medicine DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Background: OpenPrescribing is a freely accessible service that enables any user to view and analyze the National Health Service (NHS) primary care prescribing data at the level of individual practices. This tool is intended to improve the quality, safety, and cost-effectiveness of prescribing.

Objective: We aimed to measure the impact of OpenPrescribing being viewed on subsequent prescribing. Read More

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http://www.jmir.org/2019/1/e10929/
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http://dx.doi.org/10.2196/10929DOI Listing
January 2019
4 Reads

Proposed changes to the ACR phantom filling procedure for more accurate and consistent activity concentrations.

J Appl Clin Med Phys 2019 Feb 16;20(2):154-156. Epub 2019 Jan 16.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Objectives: The phantom filling procedures currently specified by the American College of Radiology (ACR) for its PET accreditation program unnecessarily limit how tight the tolerances can be made on the accuracy requirements for the concentrations measured in the resultant images.

Methods: New procedures are proposed to improve the accuracy and consistency of the concentrations within the phantom at the time of imaging. These improvements are gained by exchanging the difficult process of accurately measuring a dose with the more easily achieved accurate measurements of time and liquid volume to control final radioactivity concentrations. Read More

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http://dx.doi.org/10.1002/acm2.12531DOI Listing
February 2019
1 Read

Bioinformatics Basics for High-Throughput Hybridization-Based Targeted DNA Sequencing from FFPE-Derived Tumor Specimens: From Reads to Variants.

Methods Mol Biol 2019 ;1908:37-48

Center for Advanced Laboratory Medicine, University of California San Diego Health, La Jolla, CA, USA.

The use of next-generation sequencing and hybridization-based capture for target enrichment have enabled the interrogation of coding regions of several clinically significant cancer genes in tumor specimens using both targeted panels of a few to hundreds of genes, to whole-exome panels encompassing coding regions of all genes in the genome. Next-generation sequencing (NGS) technologies produce millions of relatively short segments of sequences or reads that require bioinformatics tools to map reads back to a reference genome using various read alignment tools, as well as to determine differences between single bases (single nucleotide variants or SNVs) or multiple bases (insertions and deletions or indels) between the aligned reads and the reference genome to call variants. In addition to single nucleotide changes or small insertions and deletions, high copy gains and losses can also be gleaned from NGS data to call gene amplifications and deletions. Read More

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http://dx.doi.org/10.1007/978-1-4939-9004-7_3DOI Listing
January 2019
1 Read

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

ACS Cent Sci 2018 Dec 5;4(12):1727-1741. Epub 2018 Dec 5.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311695PMC
December 2018
8 Reads

Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission.

Lancet Gastroenterol Hepatol 2019 Feb;4(2):135-184

Department of Global Health, University of Washington, Seattle, WA, USA.

Viral hepatitis is a major public health threat and a leading cause of death worldwide. Annual mortality from viral hepatitis is similar to that of other major infectious diseases such as HIV and tuberculosis. Highly effective prevention measures and treatments have made the global elimination of viral hepatitis a realistic goal, endorsed by all WHO member states. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24681253183027
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http://dx.doi.org/10.1016/S2468-1253(18)30270-XDOI Listing
February 2019
10 Reads

Assessment of the Medicare Advantage Risk Adjustment Model for Measuring Veterans Affairs Hospital Performance.

JAMA Netw Open 2018 Dec 7;1(8):e185993. Epub 2018 Dec 7.

Health Economics Resource Center, VA Palo Alto, Menlo Park, California.

Importance: Policymakers and consumers are eager to compare hospitals on performance metrics, such as surgical complications or unplanned readmissions, measured from administrative data. Fair comparisons depend on risk adjustment algorithms that control for differences in case mix.

Objective: To examine whether the Medicare Advantage risk adjustment system version 21 (V21) adequately risk adjusts performance metrics for Veterans Affairs (VA) hospitals. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324352PMC
December 2018
1 Read

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis.

Epilepsy Res 2019 Feb 7;150:46-57. Epub 2019 Jan 7.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FIN-70211 Kuopio, Finland.

Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-of-concept studies with limited animal numbers, and thus lack the statistical power for biomarker discovery. Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a pioneering multicenter trial investigating preclinical imaging biomarkers of PTE. EpiBios4Rx faced the issue of harmonizing the magnetic resonance imaging (MRI) procedures and imaging data metrics prior to its execution. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.001DOI Listing
February 2019
3 Reads

Science meets policy: A framework for determining impairment designation criteria for large waterbodies affected by cyanobacterial harmful algal blooms.

Harmful Algae 2019 Jan 10;81:59-64. Epub 2018 Dec 10.

F.T. Stone Laboratory, The Ohio State University, 878 Bayview Ave. P.O. Box 119, Put-In-Bay, OH, 43456, USA; Ohio Sea Grant College Program, The Ohio State University, 1314 Kinnear Rd., Research Area 100, Columbus, OH, 43212, USA.

Toxic cyanobacterial harmful algal blooms (cyanoHABs) are one of the most significant threats to the security of Earth's surface freshwaters. In the United States, the Federal Water Pollution Control Act of 1972 (i.e. Read More

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http://dx.doi.org/10.1016/j.hal.2018.11.016DOI Listing
January 2019
1 Read

Imaging and Dosimetric Study on Direct Flat-Panel Detector-Based Digital Mammography System.

J Med Phys 2018 Oct-Dec;43(4):255-263

Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.

Introduction: Image quality of digital mammography system is generally defined by three primary physical parameters, namely, contrast, resolution, and noise. Quantification of these metrics can be done by measuring objective image quality parameters defined as contrast-to-noise ratio (CNR), modulation transfer function (MTF), and noise power spectra (NPS).

Materials And Methods: In the present study, various imaging metrics such as CNR, contrast detail resolution, MTF, and NPS were evaluated for a direct flat-panel detector-based digital mammography system following the European Guidelines. Read More

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http://dx.doi.org/10.4103/jmp.JMP_64_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299749PMC
January 2019
2 Reads

HPV vaccination in a context of public mistrust and uncertainty: a systematic literature review of determinants of HPV vaccine hesitancy in Europe.

Hum Vaccin Immunother 2019 Jan 11. Epub 2019 Jan 11.

a Department of Epidemiology and Population Health , London School of Hygiene & Tropical Medicine (LSHTM) , London , UK.

Europe is increasingly described as the region in the world with the least confidence in vaccination, and particularly in the safety of vaccines. The aim of this systematic literature review was to gather and summarise all peer-reviewed and grey literature published about determinants of Human Papillomavirus (HPV) vaccine hesitancy in Europe. Ten thematic categories were identified across the 103 articles which were included in the review. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
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http://dx.doi.org/10.1080/21645515.2018.1564436DOI Listing
January 2019
8 Reads

An analysis of results in a single-blinded, prospective randomized controlled trial comparing non-fixating versus self-fixating mesh for laparoscopic inguinal hernia repair.

Surg Endosc 2019 Jan 9. Epub 2019 Jan 9.

Section of Minimally Invasive Surgery, Department of Surgery, NorthShore Center for Simulation and Innovation, NorthShore University HealthSystem, 2650 Ridge Ave, Evanston, IL, 60201, USA.

Background: It remains unclear whether use of self-fixating mesh during laparoscopic inguinal hernia repair (LIHR) impacts postoperative quality of life (QoL). We hypothesize patients receiving self-fixating mesh during totally extraperitoneal (TEP) LIHR will report less pain and improved QoL compared to those receiving non-fixating mesh.

Methods: An IRB-approved, single-blinded randomized controlled trial was conducted. Read More

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http://link.springer.com/10.1007/s00464-018-6555-8
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http://dx.doi.org/10.1007/s00464-018-6555-8DOI Listing
January 2019
8 Reads

A novel approach to evaluate the lung cancer risk of airborne particles emitted in a city.

Sci Total Environ 2019 Mar 30;656:1032-1042. Epub 2018 Nov 30.

Department of Engineering, University "Parthenope", Naples, Italy; Queensland University of Technology, Brisbane, Australia.

Air quality still represents a main threat to human health in cities. Even in developed countries, decades of air pollution control not yet allowed to reduce pollutant concentrations in urban areas adequately. Indeed, high airborne particle concentrations are measured in several European cities; this is a main issue since particles represent a carrier for carcinogenic compounds. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.432DOI Listing
March 2019
3 Reads

The South African Regulatory System: Past, Present, and Future.

Front Pharmacol 2018 4;9:1407. Epub 2018 Dec 4.

Department of Pharmacy, Pharmacology and Postgraduate Medicine, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

The drive for improved regulatory systems and the establishment of a more effective regulatory framework in South Africa has been evident for the past two decades but despite political intentions and legislative revisions success has been limited to date. Efforts to address the increasing volume of applications that have been received have to date failed and resources have been stretched to capacity resulting in the development of a significant backlog and extended timelines for product registration. The promulgation of the recently amended Medicines and Related Substance Act of 1965 triggered the establishment of the South African Health Products Regulatory Authority (SAHPRA) as a separate juristic person outside of the National Department of Health to replace the former medicine regulatory authority the Medicines Control Council (MCC). Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01407
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http://dx.doi.org/10.3389/fphar.2018.01407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300068PMC
December 2018
10 Reads

LOADng-IoT: An Enhanced Routing Protocol for Internet of Things Applications over Low Power Networks.

Sensors (Basel) 2019 Jan 3;19(1). Epub 2019 Jan 3.

University of Fortaleza (Unifor), Fortaleza 60811-905, Fortaleza, Brazil.

The Internet of Things (IoT) is an emerging paradigm that proposes the connection of objects to exchange information in order to reach a common objective. In IoT networks, it is expected that the nodes will exchange data between each other and with external Internet services. However, due to deployment costs, not all the network devices are able to communicate with the Internet directly. Read More

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http://dx.doi.org/10.3390/s19010150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339092PMC
January 2019
1 Read

The Impact of a City-Level Minimum Wage Policy on Supermarket Food Prices by Food Quality Metrics: A Two-Year Follow Up Study.

Int J Environ Res Public Health 2019 Jan 1;16(1). Epub 2019 Jan 1.

Environmental and Occupational Health Sciences, Center for Public Health Nutrition, University of Washington, Seattle, WA 98195, USA.

: To examine the effects of increasing minimum wage on supermarket food prices in Seattle over 2 years of policy implementation, overall and differentially across food quality metrics. Prices for the UW Center for Public Health Nutrition (CPHN) market basket of 106 foods were obtained for 6 large supermarket chain stores in Seattle ("intervention") and for the same chain stores in King County ("control") at four time points: 1-month pre- (March 2015), 1-month post- (May 2015), 1-year post- (May 2016), and 2-years post-policy implementation (May 2017). Prices for all food items were standardized and converted to price per 100 kcal. Read More

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http://dx.doi.org/10.3390/ijerph16010102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339052PMC
January 2019
1 Read

Duloxetine Reduces Pain and Improves Quality of Recovery Following Total Knee Arthroplasty in Centrally Sensitized Patients: A Prospective, Randomized Controlled Study.

J Bone Joint Surg Am 2019 Jan;101(1):64-73

Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: Unexplained postoperative pain is one of the most feared complications of total knee arthroplasty (TKA). A persistent noxious peripheral stimulus, such as the pain of chronic knee osteoarthritis, can cause central sensitization in which the central nervous system becomes hyperexcitable, resulting in hypersensitivity to both noxious and non-noxious stimuli. Patients with central sensitization may be more susceptible to unexplained pain after TKA. Read More

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http://dx.doi.org/10.2106/JBJS.18.00347DOI Listing
January 2019
3 Reads

The Relationship Between Medicare Outpatient Efficiency Measure OP8 and Lumbar MRI Utilization.

J Am Coll Radiol 2018 Dec 28. Epub 2018 Dec 28.

Center for Health Care Improvement Science, Virginia Mason Medical Center, Seattle, Washington. Electronic address:

Introduction: Quality-based reporting and payment are predicated on using valid metrics. We sought to determine the relationship between widely used lumbar imaging quality metric OP8 and underlying quality as measured through actual utilization of lumbar MRI.

Methods: We performed a multi-institutional cross-sectional study using hospital-level billing data from a major commercial insurance company, including 23 Washington State hospitals from July 1, 2014, to June 30, 2015, with more than 25 eligible visits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15461440183141
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http://dx.doi.org/10.1016/j.jacr.2018.10.026DOI Listing
December 2018
3 Reads

Topic-Oriented Image Captioning Based on Order-Embedding.

IEEE Trans Image Process 2018 Dec 27. Epub 2018 Dec 27.

We present an image captioning framework that generates captions under a given topic. The topic candidates are extracted from the caption corpus. A given image's topics are then selected from these candidates by a CNN-based multilabel classifier. Read More

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http://dx.doi.org/10.1109/TIP.2018.2889922DOI Listing
December 2018
1 Read

Mistaken assumptions drive new Six Sigma model off the road.

Biochem Med (Zagreb) 2019 Feb 15;29(1):010903. Epub 2018 Dec 15.

Westgard QC, Madison, USA.

Oosterhuis and Coskun recently proposed a new model for applying the Six Sigma concept to laboratory measurement processes. In criticizing the conventional Six Sigma model, the authors misinterpret the industrial basis for Six Sigma and mixup the Six Sigma "counting methodology" with the "variation methodology", thus many later attributions, conclusions, and recommendations are also mistaken. Although the authors attempt to justify the new model based on industrial principles, they ignore the fundamental relationship between Six Sigma and the process capability indices. Read More

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http://dx.doi.org/10.11613/BM.2019.010903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294151PMC
February 2019
1 Read

Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice.

Nucleic Acids Res 2018 Dec 24. Epub 2018 Dec 24.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Dysregulated protein synthesis is a major underlying cause of many neurodevelopmental diseases including fragile X syndrome. In order to capture subtle but biologically significant differences in translation in these disorders, a robust technique is required. One powerful tool to study translational control is ribosome profiling, which is based on deep sequencing of mRNA fragments protected from ribonuclease (RNase) digestion by ribosomes. Read More

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gky1292DOI Listing
December 2018
4 Reads

Quality Improvement Initiative to Improve Abuse Screening Among Infants With Extremity Fractures.

Pediatr Emerg Care 2018 Dec 21. Epub 2018 Dec 21.

Reading Hospital, Reading.

Objectives: The aim of this study was to evaluate the effectiveness of clinical pathway implementation and quality improvement (QI) interventions to increase the percentage of infants with extremity fractures undergoing evaluation for suspected physical abuse, including skeletal survey (SS), and consultation with social work, and/or Child Protection Team.

Methods: Charts were retrospectively reviewed to establish percentage of infants less than 12 months old with extremity fractures undergoing an SS and consultation during the prepathway (January 1, 2012 to December 31, 2013) and postpathway (January 1, 2014 to June 30, 2015) periods. Using an Ishikawa framework, key process drivers were identified and additional QI interventions (clinical decision support and provider education) were developed and implemented. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001671DOI Listing
December 2018
5 Reads

Improving Handoffs Between Operating Room and Pediatric Intensive Care Teams: Before and After Study.

Pediatr Qual Saf 2018 Sep-Oct;3(5):e101. Epub 2018 Aug 30.

Department of Pediatric Critical Care Medicine, Children's Hospital at Dartmouth, Lebanon, N.H.

Introduction: Patient transfer between teams and units is known to be a high-risk event for miscommunication and therefore error. We instituted a quality improvement initiative to formalize patient handoffs from the operating room (OR) to the Pediatric Intensive Care Unit (PICU). We hypothesized that measures of information transfer would improve. Read More

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http://dx.doi.org/10.1097/pq9.0000000000000101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221591PMC
August 2018
1 Read

Are HCAHPS Scores Higher for Private vs Double-Occupancy Inpatient Rooms in Total Joint Arthroplasty Patients?

J Arthroplasty 2019 Mar 1;34(3):408-411. Epub 2018 Dec 1.

Department of Orthopedic Surgery, NYU Langone Health, NYU Langone Orthopedic Hospital, New York, New York.

Background: Private hospital rooms have a number of potential advantages compared to shared rooms, including reduced noise and increased control over the hospital environment. However, the association of room type with patient experience metrics in total joint arthroplasty (TJA) patients is currently unclear.

Methods: For private versus shared rooms, we compared our institutional Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores in patients who underwent primary TJA over a 2-year period. Read More

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http://dx.doi.org/10.1016/j.arth.2018.11.033DOI Listing
March 2019
1 Read

Age-Related Alterations in Electroencephalography Connectivity and Network Topology During n-Back Working Memory Task.

Front Hum Neurosci 2018 6;12:484. Epub 2018 Dec 6.

Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

The study of the healthy brain in elders, especially age-associated alterations in cognition, is important to understand the deficits created by Alzheimer's disease (AD), which imposes a tremendous burden on individuals, families, and society. Although, the changes in synaptic connectivity and reorganization of brain networks that accompany aging are gradually becoming understood, little is known about how normal aging affects brain inter-regional synchronization and functional networks when items are held in working memory (WM). According to the classic Sternberg WM paradigm, we recorded multichannel electroencephalography (EEG) from healthy adults (young and senior) in three different conditions, i. Read More

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http://dx.doi.org/10.3389/fnhum.2018.00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291464PMC
December 2018
2 Reads

Developing a Neuroimaging Biomarker for Amyotrophic Lateral Sclerosis: Multi-Center Data Sharing and the Road to a "Global Cohort".

Front Neurol 2018 4;9:1055. Epub 2018 Dec 4.

Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.

Neuroimaging in Amyotrophic Lateral Sclerosis (ALS) has steadily evolved from an academic exercise to a powerful clinical tool for detecting and following pathological change. Nevertheless, significant challenges need to be addressed for the translation of neuroimaging as a robust outcome-metric and biomarker in quality-of-care assessments and pharmaceutical trials. Studies have been limited by small sample sizes, poor replication, incomplete patient characterization, and substantial differences in data collection and processing. Read More

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http://dx.doi.org/10.3389/fneur.2018.01055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288231PMC
December 2018
1 Read

psims - A declarative writer for mzML and mzIdentML for Python.

Mol Cell Proteomics 2018 Dec 18. Epub 2018 Dec 18.

Boston University School of Medicine, United States of America.

mzML and mzIdentML are commonly used, powerful tools for representing mass spectrometry data and derived identification information. These formats are complex, requiring non-trivial logic to translate data into the appropriate representation. Most published implementations are tightly coupled to data structures. Read More

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http://dx.doi.org/10.1074/mcp.RP118.001070DOI Listing
December 2018
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Common Bacterial and Viral Infections: Review of Management in the Pregnant Patient.

Ann Pharmacother 2018 Dec 17:1060028018817935. Epub 2018 Dec 17.

1 University of South Carolina College of Pharmacy, Columbia, SC, USA.

Objective: To review the treatment of common bacterial and viral infections occurring in the pregnant patient.

Data Sources: A literature search of MEDLINE was performed (inception to October 2018). The Centers for Disease Control and Prevention website was utilized for additional information. Read More

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http://dx.doi.org/10.1177/1060028018817935DOI Listing
December 2018
7 Reads

Volume-of-interest CT imaging with dynamic beam filtering using multiple aperture devices.

Conf Proc Int Conf Image Form Xray Comput Tomogr 2018 May;2018:213-217

Department of Biomedical Engineering, Johns Hopkins University, Baltimore MD, USA 21205.

Interior tomography is promising approach for retaining high quality CT images within a volume-of-interest (VOI) while reducing the total patient dose. A static collimating filter can only image a centered symmetric VOI, which requires careful patient positioning and may be suboptimal for many clinical applications. Multiple aperture devices (MADs) are an emerging technology based on sequential binary filters that can provide a wide range of fluence patterns that may be adjusted dynamically with relatively small motions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291005PMC
May 2018
6 Reads

Is your assay stable? Using process stability and capability to evaluate assay performance.

Clin Chim Acta 2019 Mar 13;490:28-33. Epub 2018 Dec 13.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT, United States. Electronic address:

Background: Many laboratories are involved in efforts to increase precision and improve process capability. Metrics to evaluate performance, assess potential for improvement, and prioritize improvement projects would facilitate these efforts. We show how stability analysis can provide metrics to evaluate assay performance and indicate potential for improvement. Read More

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http://dx.doi.org/10.1016/j.cca.2018.12.015DOI Listing
March 2019
1 Read

The impact of community-based interventions for the older population: a quasi-experimental study of a hip-fracture prevention program in Norway.

BMC Geriatr 2018 Dec 13;18(1):311. Epub 2018 Dec 13.

Centre for Public Safety, Karlstad University, Karlstad, Sweden.

Background: Hip fractures among older adults are a major public health problem in many countries. Hip fractures are associated with expensive health care treatments, and serious adverse effects on patients' health and quality-of-life. In this paper, we estimate the effect of a community-based hip fracture prevention program that was initiated in 16 Norwegian municipalities in 2007. Read More

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http://dx.doi.org/10.1186/s12877-018-1004-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293629PMC
December 2018
1 Read

A novel index for assessing treatment plan quality in stereotactic radiosurgery.

J Neurosurg 2018 Dec;129(Suppl1):118-124

OBJECTIVEStereotactic radiosurgery (SRS) is characterized by high levels of conformity and steep dose gradients from the periphery of the target to surrounding tissue. Clinical studies have backed up the importance of these factors through evidence of symptomatic complications. Available data suggest that there are threshold doses above which the risk of symptomatic radionecrosis increases with the volume irradiated. Read More

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http://dx.doi.org/10.3171/2018.7.GKS18694DOI Listing
December 2018
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Efficacy of Minimally Invasive Intervention in Patients With Acute Cerebral Infarction.

J Cardiovasc Pharmacol 2019 Jan;73(1):22-26

Department of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan City, Shanxi Province, China.

Our aim was to explore the efficacy of minimally invasive intervention in patients with acute cerebral infarction (ACI). Seventy patients with ACI were randomized into either an experimental group or a control group. In addition to the regular treatment, patients in the control group also received intravenous thrombolysis with urokinase, while patients in the other group underwent percutaneous transluminal cerebral angioplasty and stenting. Read More

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http://dx.doi.org/10.1097/FJC.0000000000000625DOI Listing
January 2019
4 Reads

Standardized outcome measures for pregnancy and childbirth, an ICHOM proposal.

BMC Health Serv Res 2018 Dec 11;18(1):953. Epub 2018 Dec 11.

International Consortium for Health Outcomes Measurement, Cambridge, MA, USA.

Background: Value-based health care aims to optimize the balance of patient outcomes and health care costs. To improve value in perinatal care using this strategy, standard outcomes must first be defined. The objective of this work was to define a minimum, internationally appropriate set of outcome measures for evaluating and improving perinatal care with a focus on outcomes that matter to women and their families. Read More

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http://dx.doi.org/10.1186/s12913-018-3732-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290550PMC
December 2018
3 Reads

Abnormal Topology of the Structural Connectome in the Limbic Cortico-Basal-Ganglia Circuit and Default-Mode Network Among Primary Insomnia Patients.

Front Neurosci 2018 23;12:860. Epub 2018 Nov 23.

Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.

Primary insomnia (PI) is the second most common mental disorder. However, the topologic alterations in structural brain connectome in patients with PI remain largely unknown. A total of 44 PI patients and 46 age-, gender-, and education level matched healthy control (HC) participants were recruited in this study. Read More

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http://dx.doi.org/10.3389/fnins.2018.00860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266325PMC
November 2018
7 Reads

Design, Optimization, and Multisite Evaluation of a Targeted Next-Generation Sequencing Assay System for Chimeric RNAs from Gene Fusions and Exon-Skipping Events in Non-Small Cell Lung Cancer.

J Mol Diagn 2018 Dec 4. Epub 2018 Dec 4.

Asuragen, Inc., Austin, Texas. Electronic address:

Lung cancer accounts for approximately 14% of all newly diagnosed cancers and is the leading cause of cancer-related deaths. Chimeric RNA resulting from gene fusions (RNA fusions) and other RNA splicing errors are driver events and clinically addressable targets for non-small cell lung cancer (NSCLC). The reliable assessment of these RNA markers by next-generation sequencing requires integrated reagents, protocols, and interpretive software that can harmonize procedures and ensure consistent results across laboratories. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15251578183035
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http://dx.doi.org/10.1016/j.jmoldx.2018.10.003DOI Listing
December 2018
12 Reads

Rapidly Assessing the Quality of Targeted Proteomics Experiments through Monitoring Stable-Isotope Labeled Standards.

J Proteome Res 2019 Feb 19;18(2):694-699. Epub 2018 Dec 19.

Biological Sciences Division , Pacific Northwest National Laboratory , Richland Washington 99336 , United States.

Targeted proteomics experiments based on selected reaction monitoring (SRM) have gained wide adoption in the use of clinical biomarkers, cellular modeling, and numerous other biological experiments due to their highly accurate and reproducible quantification. The quantitative accuracy in targeted proteomics experiments is reliant on the stable-isotope, heavy-labeled peptide standards that are spiked into a sample and used as a reference when calculating the abundance of endogenous peptides. Therefore, the quality of measurement for these standards is a critical factor in determining whether data acquisition was successful. Read More

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http://dx.doi.org/10.1021/acs.jproteome.8b00688DOI Listing
February 2019
3 Reads
4.245 Impact Factor

Unexpected discrepancies in hospital administrative databases can impact the accuracy of monitoring thyroid surgery outcomes in France.

PLoS One 2018 6;13(12):e0208416. Epub 2018 Dec 6.

Department of General and Endocrine Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.

Objective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.

Background: Administrative data are increasingly used to track surgical outcomes.

Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208416PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283582PMC
December 2018
7 Reads

Alfred: Interactive multi-sample BAM alignment statistics, feature counting and feature annotation for long- and short-read sequencing.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

GeneCore, European Molecular Biology Laboratory (EMBL), Heidelberg, 69117, Germany.

Summary/motivation: Harmonizing quality control of large-scale second and third-generation sequencing datasets is key for enabling downstream computational and biological analyses. We present Alfred, an efficient and versatile command-line application that computes multi-sample quality control metrics in a read-group aware manner, across a wide variety of sequencing assays and technologies. In addition to standard quality control metrics such as GC bias, base composition, insert size and sequencing coverage distributions it supports haplotype-aware and allele-specific feature counting and feature annotation. Read More

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http://dx.doi.org/10.1093/bioinformatics/bty1007DOI Listing
December 2018
4 Reads

Assessment of quality control system by sigma metrics and quality goal index ratio: A roadmap towards preparation for NABL.

World J Methodol 2018 Nov 29;8(3):44-50. Epub 2018 Nov 29.

Department of Biochemistry, Pt. B.D. Sharma, University of Health Sciences, Rohtak 124001, Haryana, India.

Aim: To study sigma metrics and quality goal index ratio (QGI).

Methods: The retrospective study was conducted at the Clinical Biochemistry Laboratory, PGIMS, Rohtak, which recently became a National Accreditation Board for Testing and Calibration of Laboratories accredited lab as per the International Organization for Standardization 15189:2012 and provides service to a > 1700-bed tertiary care hospital. Data of 16 analytes was extracted over a period of one year from January 2017 to December 2017 for calculation of precision, accuracy, sigma metrics, total error, and QGI. Read More

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http://dx.doi.org/10.5662/wjm.v8.i3.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275555PMC
November 2018
2 Reads

Failure to Rescue After Emergency General Surgery in Geriatric Patients: Does Frailty Matter?

J Surg Res 2019 Jan 17;233:397-402. Epub 2018 Sep 17.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, University of Arizona, Tucson, Arizona. Electronic address:

Background: Failure to rescue (FTR) is considered as an index of quality of care provided by a hospital. However, the role of frailty in FTR remains unclear. We hypothesized that the FTR rate is higher for frail geriatric emergency general surgery (EGS) patients than nonfrail geriatric EGS patients. Read More

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http://dx.doi.org/10.1016/j.jss.2018.08.033DOI Listing
January 2019
1 Read