4,243 results match your criteria Quality Control Metrics

A Peer Data Benchmarking Intervention to Reduce Opioid Overprescribing: A Randomized Controlled Trial.

Am Surg 2022 Jun 28:31348221111519. Epub 2022 Jun 28.

Department of Surgery, 1500Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Driving physician behavior change has been an elusive goal for quality improvement efforts aimed at reducing low-value care. We proposed the use of "nudge" interventions at the surgeon level in order to reduce post-surgical opioid overprescribing in accordance with consensus guidelines.

Methods: We used 2017 Medicare data to identify outlier surgeons. Read More

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Feasibility, Acceptability, and Efficacy of Mindfulness Training in People with Upper Motor Neuron Disorders: A Systematic Review.

Arch Phys Med Rehabil 2022 Jun 24. Epub 2022 Jun 24.

Department of Physical Medicine and Rehabilitation, The University of Texas Health Sciences Center at Houston, Houston, Texas; TIRR Memorial Hermann, Houston, Texas.

Objectives: This systematic review aims to gain a comprehensive understanding of the feasibility, acceptability, and efficacy of mindfulness-based interventions (MBIs) on depression, anxiety, fatigue, and health-related quality of life among individuals with upper motor neuron disorders (UMND).

Data Sources: PubMed, PsycINFO, EMBASE, and CINAHL were searched for relevant studies published between Jan 2001 and June 2021.

Study Selection: Clinical trials published in English evaluating MBIs in adults with the four most common UMND (multiple sclerosis, brain injury including stroke, spinal cord injury, and amyotrophic lateral sclerosis) were included. Read More

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Atlantic Salmon () Performance Fed Low Trophic Ingredients in a Fish Meal and Fish Oil Free Diet.

Front Physiol 2022 8;13:884740. Epub 2022 Jun 8.

Department of Aquaculture Production Biology, Nofima, Tromsø, Norway.

To evolve fish farming in an eco-efficient way, feed production must become less dependent on forage fish-based ingredients and make more use of low trophic level organisms, including microalgae, higher plants, as filter feeding organisms and other ingredients with low competition to established food value chains. Diets nearly free of fish meal and fish oil are not a novelty but are often composed of complex mixtures, containing supplements to meet the farmed animal's nutritional requirements. Sustaining a growing aquaculture production, maintaining at the same time fish health, welfare, and profitability, and meeting strict environmental and food safety demands, is challenging and requires new technologies, great investments, and more knowledge. Read More

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Preanalytical Variables and Sample Quality Control for Clinical Variant Analysis.

Methods Mol Biol 2022 ;2493:331-351

Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.

Broad molecular profiling by next-generation sequencing of solid tumors has become a critical tool for clinical decision-making in the era of precision oncology. In addition to many already approved targeted therapies, more than half of ongoing oncology-related clinical trials are biomarker-driven. Therefore, accurate and reliable assays are needed to assess the genetic make-up of tumor cells and guide clinicians in the therapy decision process. Read More

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Retrospective evaluation of an intervention based on training sessions to increase the use of control charts in hospitals.

BMJ Qual Saf 2022 Jun 24. Epub 2022 Jun 24.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: Statistical process control charts (SPCs) distinguish signal from noise in quality and safety metrics and thus enable resources to be targeted towards the most suitable actions for improving processes and outcomes. Nevertheless, according to a recent study, SPCs are not widely used by hospital boards in England. To address this, an educational training initiative with training sessions lasting less than one and a half days was established to increase uptake of SPCs in board papers. Read More

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Algorithms used in medical image segmentation for 3D printing and how to understand and quantify their performance.

3D Print Med 2022 Jun 24;8(1):18. Epub 2022 Jun 24.

US Department of Veterans Affairs, Veterans Health Administration, Office of Healthcare Innovation and Learning, Seattle, WA, 98109, USA.

Background: 3D printing (3DP) has enabled medical professionals to create patient-specific medical devices to assist in surgical planning. Anatomical models can be generated from patient scans using a wide array of software, but there are limited studies on the geometric variance that is introduced during the digital conversion of images to models. The final accuracy of the 3D printed model is a function of manufacturing hardware quality control and the variability introduced during the multiple digital steps that convert patient scans to a printable format. Read More

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Tackling Quality-It's Never a Level Playing Field: Companion Piece to the Neurology Outcome Measure Set.

Neurol Clin Pract 2022 Jun;12(3):270-272

Emory University (BC), Atlanta, GA; Phoenix Children's Hospital (KW), Phoenix, AZ; Intermountain Medical Group (MW), Murray, UT; American Academy of Neurology (DC), Minneapolis, MN; and University of Colorado Anschutz Medical Campus (KN), Aurora, CO.

The American Academy of Neurology (AAN) has recently proposed 3 outcome metrics crafted to be both broadly applicable across neurologic diseases and to function as potential tools to facilitate quality improvement. These measures should be of interest to physicians and payers due to the increasing linkage of reimbursement to quality care. However, the use of quality measures cannot exist in a vacuum as external factors outside of physician control can negatively affect these metrics. Read More

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Comparison of Quality of Carbohydrate Metrics Related to Fasting Insulin, Glycosylated Hemoglobin and HOMA-IR in Brazilian Adolescents.

Nutrients 2022 Jun 19;14(12). Epub 2022 Jun 19.

Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rua São Francisco Xavier 524, Pavilhão João Lyra Filho, 7º Andar, Rio de Janeiro 20550-900, RJ, Brazil.

Low glycemic index (GI) and glycemic load (GL) diets are effective for glycemic control (GC) associated with a carbohydrate-controlled meal plan. However, whether GI and GL peaks are related to GC is unknown.

Objective: To compare the daily GI (DGI)/GL (DGL) and average GI (AvGI)/GL (AvGL) of meals (accounting for peaks) related to GC markers (GCM) in Brazilian adolescents. Read More

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Exploring complementary and competitive relations between non-communicable disease services and other health extension programme services in Ethiopia: a multilevel analysis.

BMJ Glob Health 2022 Jun;7(6)

Department of Public Health, Faculty of Health, University of Canberra, Canberra, ACT, Australia.

Background: Ethiopia has recently revitalised its health extension programme (HEP) to address the rising burden of non-communicable diseases (NCDs). We examined the effects of existing essential HEP services on the uptake of NCD preventive services.

Methods: We applied a mixed-effect non-linear model with a logit link function to identify factors associated with a community resident's probability of receiving NCD prevention services through the HEP. Read More

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Measuring the Effect of Using a Borderline Students' Characteristics Model on Reliability of Objective Structured Clinical Examination.

Cureus 2022 May 20;14(5):e25156. Epub 2022 May 20.

Medical Education, Faculty of Medicine, Suez Canal University, Ismailia, EGY.

Defining borderline group is a crucial step when applying standard setting methods in objective structured clinical examination (OSCE). However, it is the most challenging and demanding task. This study aimed to measure the effect of using a model describing characteristics of borderline students on the reliability and metrics of OSCE. Read More

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Dynamic incorporation of real world evidence within the framework of adaptive design.

J Biopharm Stat 2022 Jun 22:1-13. Epub 2022 Jun 22.

Statistics, Pfizer Inc, New York, New York, USA.

For the clinical studies in rare diseases or small patient populations, having an adequately powered randomized controlled trial is further complicated by variability. As such, sample size re-estimation can be a useful tool if at an interim look the trial sample size needs to be increased to achieve adequate power to reject the null hypothesis. Meanwhile, borrowing or extrapolating information from real-world data or real-world evidence has gained increasing use in trial design and analysis since 2014. Read More

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Evaluating denoising strategies in resting-state functional magnetic resonance in traumatic brain injury (EpiBioS4Rx).

Hum Brain Mapp 2022 Jun 20. Epub 2022 Jun 20.

Department of Psychology, University of California Los Angeles, Los Angeles, California, USA.

Resting-state functional MRI is increasingly used in the clinical setting and is now included in some diagnostic guidelines for severe brain injury patients. However, to ensure high-quality data, one should mitigate fMRI-related noise typical of this population. Therefore, we aimed to evaluate the ability of different preprocessing strategies to mitigate noise-related signal (i. Read More

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High-stage Device-related Pressure Injury Reduction in a Neonatal Intensive Care Unit: A Quality Improvement Project.

Pediatr Qual Saf 2022 May-Jun;7(3):e554. Epub 2022 Jun 14.

Rady Children's Hospital San Diego, San Diego, Calif.

Introduction: Pressure injuries are a common complication in neonatal intensive care settings, and neonates are at high risk for this hospital-acquired condition. Pressure injury rates in the neonatal intensive care unit (NICU) at Rady Children's Hospital were higher than reported national comparisons in 2018. Device-related high-stage hospital-acquired pressure injuries (HAPI) were the most common injury source. Read More

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Essential CGM Metrics: The Principal Dimensions of Glycemic Control in Diabetes.

Diabetes Technol Ther 2022 Jun 17. Epub 2022 Jun 17.

University of Virginia, 2358, Center for Diabetes Technology, Charlottesville, Virginia, United States;

Background: With the proliferation of continuous glucose monitoring (CGM), a number of metrics were developed to assess quality of glycemic control. Many of them are highly correlated. Thus, we aim to identify the principal dimensions of glycemic control - a minimal set of metrics, necessary and sufficient for comprehensive assessment of diabetes management. Read More

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COVID-19 data reporting systems in Africa reveal insights for future pandemics.

Epidemiol Infect 2022 Jun 16;150:e119. Epub 2022 Jun 16.

Center for Tropical Research, University of California, Los Angeles, CA, USA.

Globally, countries have used diverse methods to report data during the COVID-19 pandemic. Using international guidelines and principles of emergency management, we compare national data reporting systems in African countries in order to determine lessons for future pandemics. We analyse COVID-19 reporting practices across 54 African countries through 2020. Read More

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Benefit and cost of repeating a severe acute respiratory coronavirus virus 2 (SARS-CoV-2) polymerase chain reaction (PCR) test after the second day of hospitalization in five hospitals during various community prevalences and vaccination rates.

Infect Control Hosp Epidemiol 2022 Jun 16:1-4. Epub 2022 Jun 16.

Infectious Diseases Department, Rochester Regional Health, Rochester, New York.

At our hospital, universal severe acute respiratory coronavirus virus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing was performed upon admission and again after 2 inpatient days. As community-wide prevalence, admission, and vaccination rates varied, the number needed to benefit fluctuated between 16 and 769 and the cost per additional detection fluctuated between $800 and $29,400. These 2 metrics were negatively associated with new hospital admissions. Read More

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YouTube as a source of patient education information for elbow ulnar collateral ligament injuries: a quality control content analysis.

Clin Shoulder Elb 2022 Jun 23;25(2):145-153. Epub 2022 May 23.

Weill Cornell Medicine, New York, NY, USA.

Background: While online orthopedic resources are becoming an increasingly popular avenue for patient education, videos on YouTube are not subject to peer review. The purpose of this cross-sectional study was to evaluate the quality of YouTube videos for patient education in ulnar collateral ligament (UCL) injuries of the elbow.

Methods: A search of keywords for UCL injury was conducted through the YouTube search engine. Read More

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Enhancing global health security in Thailand: Strengths and challenges of initiating a One Health approach to avian influenza surveillance.

One Health 2022 Jun 11;14:100397. Epub 2022 May 11.

Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.

Infectious disease surveillance systems support early warning, promote preparedness, and inform public health response. Pathogens that have human, animal, and environmental reservoirs should be monitored through systems that incorporate a One Health approach. In 2016, Thailand's federal government piloted an avian influenza (AI) surveillance system that integrates stakeholders from human, animal, and environmental sectors, at the central level and in four provinces to monitor influenza A viruses within human, waterfowl, and poultry populations. Read More

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A high-quality de novo genome assembly based on nanopore sequencing of a wild-caught coconut rhinoceros beetle (Oryctes rhinoceros).

BMC Genomics 2022 Jun 7;23(1):426. Epub 2022 Jun 7.

School of Biological Sciences, The University of Queensland, St. Lucia, Australia.

Background: An optimal starting point for relating genome function to organismal biology is a high-quality nuclear genome assembly, and long-read sequencing is revolutionizing the production of this genomic resource in insects. Despite this, nuclear genome assemblies have been under-represented for agricultural insect pests, particularly from the order Coleoptera. Here we present a de novo genome assembly and structural annotation for the coconut rhinoceros beetle, Oryctes rhinoceros (Coleoptera: Scarabaeidae), based on Oxford Nanopore Technologies (ONT) long-read data generated from a wild-caught female, as well as the assembly process that also led to the recovery of the complete circular genome assemblies of the beetle's mitochondrial genome and that of the biocontrol agent, Oryctes rhinoceros nudivirus (OrNV). Read More

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HPiP: an R/Bioconductor package for predicting host-pathogen protein-protein interactions from protein sequences using ensemble machine learning approach.

Bioinform Adv 2022 23;2(1):vbac038. Epub 2022 May 23.

Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.

Motivation: Despite arduous and time-consuming experimental efforts, protein-protein interactions (PPIs) for many pathogenic microbes with their human host are still unknown, limiting our understanding of the intricate interactions during infection and the identification of therapeutic targets. Since computational tools offer a promising alternative, we developed an R/Bioconductor package, HPiP (Host-Pathogen Interaction Prediction) software with a series of amino acid sequence property descriptors and an ensemble machine learning classifiers to predict the yet unmapped interactions between pathogen and host proteins.

Results: Using severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) or the novel SARS-CoV-2 coronavirus-human PPI training sets as a case study, we show that HPiP achieves a good performance with PPI predictions between SARS-CoV-2 and human proteins, which we confirmed experimentally in human monocyte THP-1 cells, and with several quality control metrics. Read More

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A Framework for Integrating Continuous Glucose Monitor-Derived Metrics into Economic Evaluations in Type 1 Diabetes.

Pharmacoeconomics 2022 Jun 7. Epub 2022 Jun 7.

Eli Lilly and Company, Indianapolis, IN, USA.

Economic models in type 1 diabetes have relied on a change in haemoglobin A1c as the link between the blood glucose trajectory and long-term clinical outcomes, including microvascular and macrovascular disease. The landscape has changed in the past decade with the availability of regulatory approved, accurate and convenient continuous glucose monitoring devices and their ability to track patients' glucose levels over time. The data emerging from continuous glucose monitoring have enriched the clinical understanding of the disease and indirectly of patients' behaviour. Read More

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Risk of COPD exacerbation is increased by poor sleep quality and modified by social adversity.

Sleep 2022 Jun 6. Epub 2022 Jun 6.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Study Objectives: Sleep is an important dimension in the care of chronic obstructive pulmonary disease (COPD), but its relevance to exacerbations is unclear. We wanted to assess whether sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) is associated with an increased risk of COPD exacerbations and does this differ by socio-environmental exposures.

Methods: We included 1647 current and former smokers with spirometrically confirmed COPD from the SPIROMICS cohort. Read More

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Assessment of Statistical Process Control Based DVH Action Levels for Systematic Multi-Leaf Collimator Errors in Cervical Cancer RapidArc Plans.

Front Oncol 2022 18;12:862635. Epub 2022 May 18.

Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: In the patient-specific quality assurance (QA), DVH is a critical clinically relevant parameter that is finally used to determine the safety and effectiveness of radiotherapy. However, a consensus on DVH-based action levels has not been reached yet. The aim of this study is to explore reasonable DVH-based action levels and optimal DVH metrics in detecting systematic MLC errors for cervical cancer RapidArc plans. Read More

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Benchmarking Low-Frequency Variant Calling With Long-Read Data on Mitochondrial DNA.

Front Genet 2022 19;13:887644. Epub 2022 May 19.

Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.

Sequencing quality has improved over the last decade for long-reads, allowing for more accurate detection of somatic low-frequency variants. In this study, we used mixtures of mitochondrial samples with different haplogroups (i.e. Read More

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Can water composition and weather factors predict fecal indicator bacteria removal in retention ponds in variable weather conditions?

Sci Total Environ 2022 Sep 2;838(Pt 3):156410. Epub 2022 Jun 2.

Department of Civil and Environmental Engineering, University of California Los Angeles, CA, USA. Electronic address:

Retention ponds provide benefits including flood control, groundwater recharge, and water quality improvement, but changes in weather conditions could limit the effectiveness in improving microbial water quality metrics. The concentration of fecal indicator bacteria (FIB), which is used as regulatory standards to assess microbial water quality in retention ponds, could vary widely based on many factors including local weather and influent water chemistry and composition. In this critical review, we analyzed 7421 data collected from 19 retention ponds across North America listed in the International Stormwater BMP Database to examine if variable FIB removal in the field conditions can be predicted based on changes in these weather and water composition factors. Read More

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September 2022

popsicleR: A R Package for Pre-processing and Quality Control Analysis of Single Cell RNA-seq Data.

J Mol Biol 2022 Jun 24;434(11):167560. Epub 2022 Mar 24.

Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

The advent of single-cell sequencing is providing unprecedented opportunities to disentangle tissue complexity and investigate cell identities and functions. However, the analysis of single cell data is a challenging, multi-step process that requires both advanced computational skills and biological sensibility. When dealing with single cell RNA-seq (scRNA-seq) data, the presence of technical artifacts, noise, and biological biases imposes to first identify, and eventually remove, unreliable signals from low-quality cells and unwanted sources of variation that might affect the efficacy of subsequent downstream modules. Read More

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After weight loss, what skin removal procedure has the most effect using Body Q metrics?

Surg Obes Relat Dis 2022 May 5. Epub 2022 May 5.

Division for Plastic Surgery, Department of Trauma, Hand and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany; Department for Plastic and Reconstructive Surgery, Institute for Muskuloskeletal Medicine, Westfaelische Wilhelms-University Muenster, Muenster, Germany; Plastic, Reconstructive, and Aesthetic Surgery, Hand Surgery, Fachklinik Hornheide, Muenster, Germany.

Background: Although postbariatric body contouring procedures have the ultimate goal of restoring quality of life, there currently exist minimal data assessing the effect of these procedures.

Objectives: To identify the most important body contouring procedure for quality of life (QoL).

Setting: University Hospital, Online Questionnaire, Germany. Read More

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The effect of hemolysis on quality control metrics for noninvasive prenatal testing.

BMC Med Genomics 2022 Jun 4;15(1):125. Epub 2022 Jun 4.

BGI Genomics, BGI-Shenzhen, Shenzhen, 518083, China.

Background: Noninvasive prenatal testing (NIPT) is the testing of blood samples from pregnant women to screen for fetal risk of chromosomal disorders. Even though in vitro hemolysis of blood specimens is common in clinical laboratories, its influence on NIPT has not been well investigated.

Methods: Peripheral blood samples were collected from 205 pregnant women and categorized according to the concentration of free hemoglobin in the plasma. Read More

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The burden of pneumoconiosis in China: an analysis from the Global Burden of Disease Study 2019.

BMC Public Health 2022 Jun 3;22(1):1114. Epub 2022 Jun 3.

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, 100050, China.

Background: Pneumoconiosis refers to a class of serious diseases threatening the health of workers exposed to coal or silicosis dust. However, the burden of pneumoconiosis is unavailable in China.

Methods: Incident cases, deaths, and disability-adjusted life years (DALYs) from pneumoconiosis and its subtypes in China were estimated from the Global Burden of Disease Study 2019 using a Bayesian meta-regression method. Read More

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Prognostic Value of Time in Blood Pressure Target Range Among Patients With Heart Failure.

JACC Heart Fail 2022 Jun 6;10(6):369-379. Epub 2022 Apr 6.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China. Electronic address:

Background: Blood pressure (BP) is a continuous and dynamic measure. However, standard BP control metrics may not reflect the variability in BP over time.

Objectives: This study assessed the prognostic value of time in BP target range among hypertensive patients with heart failure (HF). Read More

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