1,691 results match your criteria Quality Control Metrics


Quality control optimization part II: A method to optimize the accuracy of laboratory quality control.

Clin Chim Acta 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, University of Utah, Salt Lake City, UT, United States of America. Electronic address:

Background: Quality control (QC) can be viewed as a diagnostic test that is used to determine whether an assay is in statistical control. Using this framework, QC performance can be evaluated using familiar metrics associated with diagnostic tests. QC plan parameters can be adjusted to optimize performance metrics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193179
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http://dx.doi.org/10.1016/j.cca.2019.04.054DOI Listing
April 2019
1 Read

The Public Health Leadership and Implementation Academy for Noncommunicable Diseases.

Prev Chronic Dis 2019 Apr 18;16:E49. Epub 2019 Apr 18.

Rollins School of Public Health, Emory University, 1518 Clifton Rd, Rm 7041 CNR Building, Atlanta, GA. Email:

Purpose And Objectives: Low- and middle-income countries (LMICs) have a large burden of noncommunicable diseases and confront leadership capacity challenges and gaps in implementation of proven interventions. To address these issues, we designed the Public Health Leadership and Implementation Academy (PH-LEADER) for noncommunicable diseases. The objective of this program evaluation was to assess the quality and effectiveness of PH-LEADER. Read More

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http://www.cdc.gov/pcd/issues/2019/18_0517.htm
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http://dx.doi.org/10.5888/pcd16.180517DOI Listing
April 2019
1 Read

An internet delivered cognitive behavioural therapy pain management programme for spinal cord injury pain: A randomised controlled trial.

Eur J Pain 2019 Apr 19. Epub 2019 Apr 19.

UCD, School of Public Health, Physiotherapy and Sports Science, Health Science Centre, University College Dublin, Belfield, Dublin4.

Chronic pain is common after spinal cord injury (SCI) and dedicated SCI cognitive behavioural therapy pain management programmes (CBT-PMPs) have a growing evidence-base to support their uptake clinically. The development of internet-delivered treatment options may overcome barriers to the access and uptake of centre-based programmes. This study examines such an approach on quality of lie (QoL), pain, mood and sleep. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1402
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http://dx.doi.org/10.1002/ejp.1402DOI Listing
April 2019
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Performance and workflow assessment of six nucleic acid extraction technologies for use in resource limited settings.

PLoS One 2019 18;14(4):e0215753. Epub 2019 Apr 18.

PATH, Seattle, Washington, United States of America.

Infectious disease nucleic acid amplification technologies (NAAT) have superior sensitivity, specificity, and rapid time to result compared to traditional microbiological methods. Recovery of concentrated, high quality pathogen nucleic acid (NA) from complex specimen matrices is required for optimal performance of several NA amplification/detection technologies such as polymerase chain reaction (PCR). Fully integrated NAAT platforms that enable rapid sample-to-result workflows with minimal user input are generally restricted to larger reference lab settings, and their complexity and cost are prohibitive to widespread implementation in resource limited settings (RLS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215753PLOS

HistoQC: An Open-Source Quality Control Tool for Digital Pathology Slides.

JCO Clin Cancer Inform 2019 Apr;3:1-7

1 Case Western Reserve University, Cleveland, OH.

Purpose: Digital pathology (DP), referring to the digitization of tissue slides, is beginning to change the landscape of clinical diagnostic workflows and has engendered active research within the area of computational pathology. One of the challenges in DP is the presence of artefacts and batch effects, unintentionally introduced during both routine slide preparation (eg, staining, tissue folding) and digitization (eg, blurriness, variations in contrast and hue). Manual review of glass and digital slides is laborious, qualitative, and subject to intra- and inter-reader variability. Read More

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http://dx.doi.org/10.1200/CCI.18.00157DOI Listing

Multi-parametric Standardization of Fluorescence Imaging Systems Based on a Composite Phantom.

IEEE Trans Biomed Eng 2019 Apr 11. Epub 2019 Apr 11.

Objective: Fluorescence molecular imaging (FMI) has emerged as a promising tool for surgical guidance in oncology, with one of the few remaining challenges being the ability to offer quality control and data referencing. This study investigates the use of a novel composite phantom to correct and benchmark FMI systems.

Methods: This study extends on previous work by describing a phantom design that can provide a more complete assessment of FMI systems through quantification of dynamic range and determination of spatial illumination patterns for both reflectance and fluorescence imaging. Read More

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http://dx.doi.org/10.1109/TBME.2019.2910733DOI Listing

Do health systems respond to the quality of their competitors?

Am J Manag Care 2019 Apr 1;25(4):e104-e110. Epub 2019 Apr 1.

Daniel J. Crespin, PhD, Division of Health Policy and Management, University of Minnesota School of Public Health, 420 Delaware St SE, MMC 729, Minneapolis, MN 55455. Email:

Objectives: Some large employers and healthcare analysts have advocated for retail competition that relies on providers competing on performance metrics to improve care quality. Using publicly available performance measures, we determined whether health systems increased the quality of diabetes care provided by their clinics based on performance relative to competitors.

Study Design: Our analysis examined publicly reported performance measures of diabetes care from 2006 to 2013 for clinics in Minnesota health systems. Read More

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April 2019
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Crowdsourced MRI quality metrics and expert quality annotations for training of humans and machines.

Sci Data 2019 Apr 11;6(1):30. Epub 2019 Apr 11.

Deptartment of Psychology, Stanford University, Stanford, CA, USA.

The neuroimaging community is steering towards increasingly large sample sizes, which are highly heterogeneous because they can only be acquired by multi-site consortia. The visual assessment of every imaging scan is a necessary quality control step, yet arduous and time-consuming. A sizeable body of evidence shows that images of low quality are a source of variability that may be comparable to the effect size under study. Read More

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http://dx.doi.org/10.1038/s41597-019-0035-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472378PMC
April 2019
1 Read

Quality control optimization part I: Metrics for evaluating predictive performance of quality control.

Clin Chim Acta 2019 Apr 8;495:174-184. Epub 2019 Apr 8.

The Department of Pathology, University of Utah, Salt Lake City, UT, United States of America. Electronic address:

Background: Quality control (QC) policies are usually designed using power curves. This type of analysis reasons from a cause (a shift in the assay results) to an effect (a signal from the QC monitoring process). End users face a different problem: they must reason from an effect (QC signal) to a cause. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.053DOI Listing
April 2019
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Technical Note: Assessing the performance of monthly CBCT image quality QA.

Med Phys 2019 Apr 11. Epub 2019 Apr 11.

Department of Radiation Medicine and Applied Sciences, University of California San Diego, 3855 Health Sciences Dr, La Jolla, CA, USA, 92093.

Purpose: To assess the performance of routine CBCT quality assurance (QA) at predicting and diagnosing clinically recognizable linac CBCT image quality issues.

Methods: Monthly automated linac CBCT image quality QA data were acquired on eight Varian linacs (Varian Medical Systems, Palo Alto, CA) using the CATPHAN 500 series phantom (The Phantom Laboratory, Inc., Greenwich, NY) and Total QA software (Image Owl, Inc. Read More

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http://dx.doi.org/10.1002/mp.13535DOI Listing
April 2019
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Development of macroinvertebrate multimetric index for ecological evaluation of a river in North Central Nigeria.

Environ Monit Assess 2019 Apr 10;191(5):274. Epub 2019 Apr 10.

Unilever Centre for Environmental Water Quality, Institute for Water Research, Rhodes University, P.O. Box 94, Grahamstown, 6140, South Africa.

A macroinvertebrate-based multimetric index was developed for River Chanchaga, North Central Nigeria. Macroinvertebrates and physicochemical variables were sampled seasonally between March 2017 and February 2018 from four stations: station 1 (least impacted control station) and three downstream stations 2, 3 and 4. A total of 29 macroinvertebrate metrics in four categories, richness, abundance, composition and diversity, were evaluated for their potential to discriminate between the stations, seasonal stability and redundancy. Read More

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http://dx.doi.org/10.1007/s10661-019-7438-8DOI Listing
April 2019
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Cold storage of porcine hepatocyte spheroids for spheroid bioartificial liver.

Xenotransplantation 2019 Apr 10:e12512. Epub 2019 Apr 10.

Department of Surgery, Mayo Clinic, Rochester, Minnesota.

Background And Aims: Cell-based therapies for liver disease such as bioartificial liver rely on a large quantity and high quality of hepatocytes. Cold storage was previously shown to be a better way to preserve the viability and functionality of hepatocytes during transportation rather than freezing, but this was only proved at a lower density of rat hepatocytes spheroids. The purpose of this study was to optimize conditions for cold storage of high density of primary porcine hepatocyte spheroids. Read More

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http://dx.doi.org/10.1111/xen.12512DOI Listing
April 2019
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Differentiation of avocados according to their botanical variety using liquid chromatographic fingerprinting and multivariate classification tree.

J Sci Food Agric 2019 Apr 5. Epub 2019 Apr 5.

Department of Analytical Chemistry, University of Granada, c/ Fuentenueva, s.n, E-18071, Granada, Spain.

Background: The oil content, composition and marketing threshold value of an avocado depends on the cultivar hence, identifying the cultivar of the avocado fruit is desirable. However, analytical methods have not been reported with this aim.

Results: A multivariate classification tree method was proposed to discriminate three commercial botanical varieties of avocado: Hass, Fuerte and Bacon, using liquid chromatography coupled to a charged aerosol detector (HPLC-CAD). Read More

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http://dx.doi.org/10.1002/jsfa.9725DOI Listing
April 2019
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Standardized data quality acceptance criteria for a rapid Escherichia coli qPCR method (Draft Method C) for water quality monitoring at recreational beaches.

Water Res 2019 Jun 15;156:456-464. Epub 2019 Mar 15.

U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 26 W. M.L. King Dr, Cincinnati, OH, 45268, USA. Electronic address:

There is growing interest in the application of rapid quantitative polymerase chain reaction (qPCR) and other PCR-based methods for recreational water quality monitoring and management programs. This interest has strengthened given the publication of U.S. Read More

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http://dx.doi.org/10.1016/j.watres.2019.03.011DOI Listing
June 2019
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Polymerase chain reaction for antigen receptor rearrangement: Benchmarking performance of a lymphoid clonality assay in diverse canine sample types.

J Vet Intern Med 2019 Apr 2. Epub 2019 Apr 2.

Ethos Discovery, San Diego, California.

Background: Polymerase chain reaction for antigen receptor rearrangement (PARR) is a molecular diagnostic tool used for discrimination of lymphoid malignancies in dogs from benign processes. Assay variations have been described and are commercially available, but performance metrics are not uniformly reported.

Objectives: To describe performance (accuracy, sensitivity, specificity) and rigorous benchmarking of a PARR protocol (ePARR) in clinically relevant samples. Read More

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http://dx.doi.org/10.1111/jvim.15485DOI Listing
April 2019
2 Reads

What matters to medical ward patients, and do we measure it? A qualitative comparison of patient priorities and current practice in quality measurement, on UK NHS medical wards.

BMJ Open 2019 Mar 30;9(3):e024058. Epub 2019 Mar 30.

Centre for Implementation Science, Kings College London, London, UK.

Objectives: To compare the quality metrics selected for public display on medical wards to patients' and carers' expressed quality priorities.

Methods: Multimodal qualitative evaluation of general medical wards and semi-structured interviews.

Setting: UK tertiary National Health Service (public) hospital. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024058DOI Listing
March 2019
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Bayesian QuickNAT: Model uncertainty in deep whole-brain segmentation for structure-wise quality control.

Neuroimage 2019 Mar 26;195:11-22. Epub 2019 Mar 26.

Artificial Intelligence in Medical Imaging (AI-Med), Department of Child and Adolescent Psychiatry, LMU, München, Germany.

We introduce Bayesian QuickNAT for the automated quality control of whole-brain segmentation on MRI T1 scans. Next to the Bayesian fully convolutional neural network, we also present inherent measures of segmentation uncertainty that allow for quality control per brain structure. For estimating model uncertainty, we follow a Bayesian approach, wherein, Monte Carlo (MC) samples from the posterior distribution are generated by keeping the dropout layers active at test time. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.03.042DOI Listing
March 2019
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A (fire)cloud-based DNA methylation data preprocessing and quality control platform.

BMC Bioinformatics 2019 Mar 29;20(1):160. Epub 2019 Mar 29.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Background: Bisulfite sequencing allows base-pair resolution profiling of DNA methylation and has recently been adapted for use in single-cells. Analyzing these data, including making comparisons with existing data, remains challenging due to the scale of the data and differences in preprocessing methods between published datasets.

Results: We present a set of preprocessing pipelines for bisulfite sequencing DNA methylation data that include a new R/Bioconductor package, scmeth, for a series of efficient QC analyses of large datasets. Read More

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http://dx.doi.org/10.1186/s12859-019-2750-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440105PMC
March 2019
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Predicting VMAT patient-specific QA results using a support vector classifier trained on treatment plan characteristics and linac QC metrics.

Phys Med Biol 2019 Mar 28. Epub 2019 Mar 28.

Medical Physics, Ottawa Hospital, Ottawa, Ontario, CANADA.

The use of treatment plan characteristics to predict patient-specific quality assurance (QA) measurement results has recently been reported as a strategy to help facilitate automated pre-treatment verification workflows or to provide a virtual assessment of delivery quality. The goal of this work is to investigate the potential of using treatment plan characteristics and linac performance metrics (i.e. Read More

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http://dx.doi.org/10.1088/1361-6560/ab142eDOI Listing
March 2019
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Mapping changes in housing in sub-Saharan Africa from 2000 to 2015.

Nature 2019 Apr 27;568(7752):391-394. Epub 2019 Mar 27.

Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Access to adequate housing is a fundamental human right, essential to human security, nutrition and health, and a core objective of the United Nations Sustainable Development Goals. Globally, the housing need is most acute in Africa, where the population will more than double by 2050. However, existing data on housing quality across Africa are limited primarily to urban areas and are mostly recorded at the national level. Read More

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http://dx.doi.org/10.1038/s41586-019-1050-5DOI Listing
April 2019
3 Reads

The evolution of catheter-associated urinary tract infection (CAUTI): Is it time for more inclusive metrics?

Infect Control Hosp Epidemiol 2019 Mar 27:1-5. Epub 2019 Mar 27.

Care Excellence,Ascension Health,St Louis, Missouri.

Catheter-associated urinary tract infection (CAUTI) has long been considered a preventable healthcare-associated infection. Many federal agencies, the Centers for Medicare and Medicaid Services (CMS), and public and private healthcare organizations have implemented strategies aimed at preventing CAUTIs. To monitor progress in CAUTI prevention, the National Healthcare Safety Network (NHSN) CAUTI metric has been adopted nationally as the primary outcome measure and has been refined over the past decades. Read More

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http://dx.doi.org/10.1017/ice.2019.43DOI Listing

Three-dimensionally-printed anthropomorphic physical phantom for mammography and digital breast tomosynthesis with custom materials, lesions, and uniform quality control region.

J Med Imaging (Bellingham) 2019 Apr 22;6(2):021604. Epub 2019 Mar 22.

Duke University, Department of Biomedical Engineering, Durham, North Carolina, United States.

Anthropomorphic breast phantoms mimic patient anatomy in order to evaluate clinical mammography and digital breast tomosynthesis system performance. Our goal is to create a modular phantom with an anthropomorphic region to allow for improved lesion and calcification detection as well as a uniform region to evaluate standard quality control (QC) metrics. Previous versions of this phantom used commercial photopolymer inkjet three-dimensional printers to recreate breast anatomy using four surfaces that were fabricated with commercial materials spanning only a limited breast density range of 36% to 64%. Read More

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http://dx.doi.org/10.1117/1.JMI.6.2.021604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428804PMC
April 2019
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Occurrence of Urban-Use Pesticides and Management with Enhanced Stormwater Control Measures at the Watershed Scale.

Environ Sci Technol 2019 Apr 22;53(7):3634-3644. Epub 2019 Mar 22.

Department of Civil and Environmental Engineering , Colorado School of Mines , Golden , Colorado 80401 , United States.

Urban-use pesticides are of increasing concern as they are widely used and have been linked to toxicity of aquatic organisms. To assess the occurrence and treatment of these pesticides in stormwater runoff, an approach combining field sampling and watershed-scale modeling was employed. Stormwater samples were collected at four locations in the lower San Diego River watershed during a storm event and analyzed for fipronil, three of its degradation products, and eight pyrethroids. Read More

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http://dx.doi.org/10.1021/acs.est.8b05833DOI Listing
April 2019
3 Reads

Methodology for whole genome sequencing of MRSA in a routine hospital microbiology laboratory.

J Clin Microbiol 2019 Mar 20. Epub 2019 Mar 20.

Department of Medicine, University of Cambridge, Box 157 Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.

There is growing evidence for the value of bacterial whole genome sequencing in hospital outbreak investigation. Our aim was to develop methods that support efficient and accurate low throughput clinical sequencing of methicillin-resistant (MRSA). Using a test panel of 25 MRSA isolates associated previously with outbreak investigations, we devised modifications to library preparation that reduced processing time by 1 hour. Read More

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http://dx.doi.org/10.1128/JCM.00180-19DOI Listing
March 2019
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B-spline based sharp feature preserving shape reconstruction approach for electrical impedance tomography.

IEEE Trans Med Imaging 2019 Mar 18. Epub 2019 Mar 18.

This paper presents a B-spline based shape reconstruction approach for electrical impedance tomography (EIT). In the proposed approach, the conductivity distribution to be reconstructed is assumed to be piecewise constant. The geometry of the inclusions is parameterized using B-spline curves, and the EIT forward solver is modified as a set of control points representing the inclusions' boundary to the data on the domain boundary. Read More

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http://dx.doi.org/10.1109/TMI.2019.2905245DOI Listing
March 2019
3 Reads

Generation of Highly Biomimetic Quality Control Materials for Noninvasive Prenatal Testing Based on Enzymatic Digestion of Matched Mother-Child Cell Lines.

Clin Chem 2019 Mar 14. Epub 2019 Mar 14.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China;

Background: Noninvasive prenatal testing (NIPT) based on cell-free DNA (cfDNA) is widely used. However, biomimetic quality control materials that have properties identical to clinical samples and that are applicable to a wide range of methodologies are still not available to support assay development, internal quality control, and proficiency testing.

Methods: We developed a set of dual enzyme-digested NIPT quality control materials (DENQCMs) that comprise simulated human plasma and mixtures of mother cell line-derived cfDNA based on DNA fragmentation factor digestion (D-cfDNA) and the matched child cell line-derived cfDNA based on micrococcal nuclease digestion (M-cfDNA). Read More

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http://dx.doi.org/10.1373/clinchem.2018.299602DOI Listing
March 2019
3 Reads
7.911 Impact Factor

Contextualizing Schistosoma haematobium transmission in Ghana: Assessment of diagnostic techniques and individual and community water-related risk factors.

Acta Trop 2019 Mar 11;194:195-203. Epub 2019 Mar 11.

Tufts University School of Engineering, Medford, MA, USA; Tufts University, Friedman School of Nutrition Science and Policy, Boston, MA, USA.

Objectives: The study assessed associations between Schistosoma haematobium infection (presence of parasite eggs in urine or hematuria) and self-reported metrics (macrohematuria, fetching surface water, or swimming) to evaluate their performance as proxies of infection in presence of regular preventive chemotherapy. It also examined community water characteristics (safe water access, surface water access, and groundwater quality) to provide context for schistosomiasis transmission in different types of communities and propose interventions.

Methods: Logistic regression was used to assess the associations between the various measured and self-reported metrics in a sample of 897 primary school children in 30 rural Ghanaian communities. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.03.016DOI Listing
March 2019
2 Reads

Automated quality control in image segmentation: application to the UK Biobank cardiovascular magnetic resonance imaging study.

J Cardiovasc Magn Reson 2019 Mar 14;21(1):18. Epub 2019 Mar 14.

Biomedical Image Analysis Group, Department of Computing, Imperial College London, Queen's Gate, London, SW7 2AZ, UK.

Background: The trend towards large-scale studies including population imaging poses new challenges in terms of quality control (QC). This is a particular issue when automatic processing tools such as image segmentation methods are employed to derive quantitative measures or biomarkers for further analyses. Manual inspection and visual QC of each segmentation result is not feasible at large scale. Read More

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http://dx.doi.org/10.1186/s12968-019-0523-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416857PMC
March 2019
1 Read
4.556 Impact Factor

"-BIRTH" protocol: observational study validating indicators for coverage and quality of maternal and newborn health care in Bangladesh, Nepal and Tanzania.

J Glob Health 2019 Jun;9(1):010902

Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene &Tropical Medicine (LSHTM), London, UK.

Background: To achieve Sustainable Development Goals and Universal Health Coverage, programmatic data are essential. The Every Newborn Action Plan, agreed by all United Nations member states and >80 development partners, includes an ambitious Measurement Improvement Roadmap. Quality of care at birth is prioritised by both Every Newborn and Ending Preventable Maternal Mortality strategies, hence metrics need to advance from health service contact alone, to content of care. Read More

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http://dx.doi.org/10.7189/jogh.09.01902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406050PMC
June 2019
3 Reads

Randomized controlled trial of harm reduction treatment for alcohol (HaRT-A) for people experiencing homelessness and alcohol use disorder.

Int J Drug Policy 2019 Mar 6;67:24-33. Epub 2019 Mar 6.

University of Washington, United States; Evergreen Treatment Services - REACH.

Background: People experiencing homelessness are disproportionately affected by alcohol use disorder (AUD). Abstinence-based treatment, however, does not optimally engage or treat this population. Thus, harm reduction treatment for alcohol (HaRT-A) was developed together with people with lived experience of homelessness and AUD and community-based agencies that serve them. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.01.002DOI Listing
March 2019
1 Read

Timely Data for Targeted Quality Improvement Interventions: Use of a Visual Analytics Dashboard for Bronchiolitis.

Appl Clin Inform 2019 Jan 6;10(1):168-174. Epub 2019 Mar 6.

Emergency Department, Children's Minnesota, Minneapolis, Minnesota, United States.

Background:  Standard methods for obtaining data may delay quality improvement (QI) interventions including for bronchiolitis, a common cause of childhood hospitalization.

Objective:  To describe the use of a dashboard in the context of a multifaceted QI intervention aimed at reducing the use of chest radiographs, bronchodilators, antibiotics, steroids, and viral testing in patients with bronchiolitis.

Methods:  This QI initiative took place at Children's Minnesota, a large, not-for-profit children's health care organization. Read More

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http://dx.doi.org/10.1055/s-0039-1679868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402943PMC
January 2019
1 Read

Adaptive multi-degree of freedom Brain Computer Interface using online feedback: Towards novel methods and metrics of mutual adaptation between humans and machines for BCI.

PLoS One 2019 6;14(3):e0212620. Epub 2019 Mar 6.

School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, Arizona, United States of America.

This paper proposes a novel adaptive online-feedback methodology for Brain Computer Interfaces (BCI). The method uses ElectroEncephaloGraphic (EEG) signals and combines motor with speech imagery to allow for tasks that involve multiple degrees of freedom (DoF). The main approach utilizes the covariance matrix descriptor as feature, and the Relevance Vector Machines (RVM) classifier. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402657PMC
March 2019
2 Reads

Does Accelerometer-based Navigation Have Any Clinical Benefit Compared with Conventional TKA? A Systematic Review.

Clin Orthop Relat Res 2019 Feb 27. Epub 2019 Feb 27.

N. C. Budhiparama, I. Lumban-Gaol, N. N. Ifran, Nicolaas Institute of Constructive Orthopaedic Research & Education Foundation for Arthroplasty & Sports Medicine at Medistra Hospital, Jakarta, Indonesia S. Parratte, Institute for Locomotion, Sainte Marguerite Hospital, Aix-Marseille University, Marseille, France R. Nelissen, Leiden University Medical Center, Leiden, The Netherlands.

Background: Accelerometer-based navigation is a handheld navigation tool that was introduced to offer a simpler technique compared with more-cumbersome computer-assisted surgery (CAS). Considering the increasing number of adopters, it seems important to evaluate the potential clinical benefits of this technology compared with conventional TKA.

Questions/purposes: In this systematic review, we asked: (1) Is accelerometer-based navigation more accurate than conventional TKA? (2) Does accelerometer-based navigation provide better functional outcome than conventional TKA? (3) Does accelerometer-based navigation increase surgical time or decrease the risk of complications or reoperations compared with conventional TKA?

Methods: This systematic review included all comparative prospective and retrospective studies published in the MEDLINE/PubMed and Cochrane libraries over the last 10 years. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000660DOI Listing
February 2019
4 Reads

Towards quality assurance and quality control in untargeted metabolomics studies.

Metabolomics 2019 Jan 3;15(1). Epub 2019 Jan 3.

National Cancer Institute, Rockville, MD, USA.

We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies. This has included (1) a QA and QC questionnaire responded to by the metabolomics community in 2015 which recommended education of the metabolomics community, development of appropriate standard reference materials and providing incentives for laboratories to apply QA and QC; (2) a 2-day 'Think Tank on Quality Assurance and Quality Control for Untargeted Metabolomic Studies' held at the National Cancer Institute's Shady Grove Campus and (3) establishment of the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) to drive forward developments in a coordinated manner. Read More

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http://dx.doi.org/10.1007/s11306-018-1460-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443086PMC
January 2019
2 Reads

Correlations between patient-perceived outcome and objectively-measured biomechanical change following Total Knee Replacement.

Gait Posture 2019 May 25;70:65-70. Epub 2019 Feb 25.

Cardiff School of Engineering, College of Physical Sciences, Cardiff University, Cardiff, United Kingdom; Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Cardiff, United Kingdom. Electronic address:

Background: Total Knee Replacement (TKR) surgery is being utilised in a younger, more active population with greater functional expectations. Understanding whether patient-perceived measures of function reflect objective biomechanical measures is critical in understanding whether functional limitations can be adequately captured within a clinical setting.

Research Question: Do changes in objective gait biomechanics measures reflect patient-reported outcome measures at approximately 12 months following TKR surgery?

Methods: Three-dimensional gait analysis was performed on 41 patients with OA who were scheduled for TKR surgery, 22 of which have returned for a (9-24 month) follow-up assessment. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.02.028DOI Listing
May 2019
1 Read

Association between Antibiotic Use and Hospital-Onset Clostridioidesdifficile Infection in U.S. Acute Care Hospitals, 2006-2012: an Ecologic Analysis.

Clin Infect Dis 2019 Mar 1. Epub 2019 Mar 1.

Division of Healthcare Quality Promotion National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention (CDC) Atlanta, GA.

Background: Unnecessary antibiotic use (AU) contributes to increased rates of Clostridioides difficile Infection (CDI). The impact of antibiotic restriction on hospital-onset CDI (HO-CDI) has not been assessed in a large group of U.S. Read More

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http://dx.doi.org/10.1093/cid/ciz169DOI Listing
March 2019
1 Read

Evaluation of Analytical Performance of Variant II Turbo HbA1c Analyzer According to Sigma Metrics.

J Med Biochem 2019 Mar 1;38(1):33-37. Epub 2019 Mar 1.

İzmir Bozyaka Egitim ve Arastirma Hastanesi, İzmir, Turkey.

Background: Hemoglobin A1c, (HbA1c) which is the major constituent of glycated hemoglobin, has been used in the follow-up of retrospective glycemia for years and in the diagnosis of diabetes mellitus nowadays. Since the analytical performance of HbA1c should be high likewise all laboratory tests, various quality control measures are used. Sigma metrics is one of these measures and it is the combination of bias, precision and total allowable error that ensures a general evaluation of analytical quality. Read More

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https://content.sciendo.com/view/journals/jomb/38/1/article-
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http://dx.doi.org/10.2478/jomb-2018-0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298457PMC
March 2019
5 Reads

Quantitative analysis of plant ER architecture and dynamics.

Nat Commun 2019 02 28;10(1):984. Epub 2019 Feb 28.

Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, UK.

The endoplasmic reticulum (ER) is a highly dynamic polygonal membrane network composed of interconnected tubules and sheets (cisternae) that forms the first compartment in the secretory pathway involved in protein translocation, folding, glycosylation, quality control, lipid synthesis, calcium signalling, and metabolon formation. Despite its central role in this plethora of biosynthetic, metabolic and physiological processes, there is little quantitative information on ER structure, morphology or dynamics. Here we describe a software package (AnalyzER) to automatically extract ER tubules and cisternae from multi-dimensional fluorescence images of plant ER. Read More

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http://dx.doi.org/10.1038/s41467-019-08893-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395764PMC
February 2019
1 Read

Towards Improving Embryo Prioritization: Parallel Next Generation Sequencing of DNA and RNA from a Single Trophectoderm Biopsy.

Sci Rep 2019 Feb 27;9(1):2853. Epub 2019 Feb 27.

CReATe Fertility Centre, Toronto, Canada.

Improved embryo prioritization is crucial in optimizing the results in assisted reproduction, especially in light of increasing utilization of elective single embryo transfers. Embryo prioritization is currently based on morphological criteria and in some cases incorporates preimplantation genetic testing for aneuploidy (PGT-A). Recent technological advances have enabled parallel genomic and transcriptomic assessment of a single cell. Read More

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http://dx.doi.org/10.1038/s41598-019-39111-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393576PMC
February 2019
3 Reads

Evaluating movement of patients with Carbapenem-Resistant Enterobacteriaceae infections in the Greater Atlanta Metropolitan Area using social network analysis.

Clin Infect Dis 2019 Feb 27. Epub 2019 Feb 27.

Georgia Emerging Infections Program, Decatur, GA, USA.

Background: Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent threat with potential for rapid spread. We evaluated the role of Medicare patient movement between facilities to model the spread of CRE within a region.

Methods: Through population-based CRE surveillance in the 8-county Atlanta Metropolitan area (population 4. Read More

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http://dx.doi.org/10.1093/cid/ciz154DOI Listing
February 2019
1 Read

Comparison of gamma index based on dosimetric error and clinically relevant dose-volume index based on three-dimensional dose prediction in breast intensity-modulated radiation therapy.

Radiat Oncol 2019 Feb 26;14(1):36. Epub 2019 Feb 26.

Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan.

Background: Measurement-guided dose reconstruction has lately attracted significant attention because it can predict the delivered patient dose distribution. Although the treatment planning system (TPS) uses sophisticated algorithm to calculate the dose distribution, the calculation accuracy depends on the particular TPS used. This study aimed to investigate the relationship between the gamma passing rate (GPR) and the clinically relevant dose-volume index based on the predicted 3D patient dose distribution derived from two TPSs (XiO, RayStation). Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1233-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390354PMC
February 2019
3 Reads

Quantitative quality-control metrics for oximetry in small vessels by visible light optical coherence tomography angiography.

Biomed Opt Express 2019 Feb 8;10(2):465-486. Epub 2019 Jan 8.

Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

Biological functions rely on local microvasculature to deliver oxygen and nutrients and carry away metabolic waste. Alterations to local oxygenation levels are manifested in diseases including cancer, diabetes mellitus, etc. The ability to quantify oxygen saturation (sO) within microvasculature to assess local tissue oxygenation and metabolic function is highly sought after. Read More

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http://dx.doi.org/10.1364/BOE.10.000465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377897PMC
February 2019
2 Reads

Pros and cons of gastric bypass surgery in individuals with obesity and type 2 diabetes: nationwide, matched, observational cohort study.

BMJ Open 2019 Jan 15;9(1):e023882. Epub 2019 Jan 15.

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

Objectives: Long-term effects of gastric bypass (GBP) surgery have been presented in observational and randomised studies, but there are only limited data for persons with obesity and type 2 diabetes mellitus (T2DM) regarding postoperative complications.

Design: This is a nationwide observational study based on two quality registers in Sweden (National Diabetes Register, NDR and Scandinavian Obesity Surgery Register, SOReg) and other national databases.

Setting: After merging the data, we matched individuals with T2DM who had undergone GBP with those not surgically treated for obesity on propensity score, based on sex, age, body mass index (BMI) and calendar time. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340417PMC
January 2019
6 Reads

Cannabis use in youth is associated with limited alterations in brain structure.

Neuropsychopharmacology 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Frequent cannabis use during adolescence has been associated with alterations in brain structure. However, studies have featured relatively inconsistent results, predominantly from small samples, and few studies have examined less frequent users to shed light on potential brain structure differences across levels of cannabis use. In this study, high-resolution T1-weighted MRIs were obtained from 781 youth aged 14-22 years who were studied as part of the Philadelphia Neurodevelopmental Cohort. Read More

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http://dx.doi.org/10.1038/s41386-019-0347-2DOI Listing
February 2019
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Effectiveness of provision of animal-source foods for supporting optimal growth and development in children 6 to 59 months of age.

Cochrane Database Syst Rev 2019 02 19;2:CD012818. Epub 2019 Feb 19.

Brown School/Institute for Public Health, Washington University in St. Louis, 1 Brookings Drive, St. Louis, Missouri, USA, 63130.

Background: Adequate nutrients early in life promote cognitive development and are critical for proper growth and functioning. The effect of individual nutrients consumed through food is often not the same as consuming the same nutrients in supplementary form due to 'food synergy', the biological and chemical interrelations that occur between nutrients. Animal-source foods, such as eggs, meat, fish, and dairy, are energy dense and contain multiple micronutrients and essential fatty acids with high bioavailability. Read More

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http://dx.doi.org/10.1002/14651858.CD012818.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380771PMC
February 2019
6 Reads

MaxQuant.Live enables global targeting of more than 25,000 peptides.

Mol Cell Proteomics 2019 Feb 12. Epub 2019 Feb 12.

Dept. Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Germany

Mass spectrometry (MS)-based proteomics is often performed in a shotgun format, in which as many peptide precursors as possible are selected from full or MS1 scans so that their fragment spectra can be recorded in MS2 scans. While achieving great proteome depths, shotgun proteomics cannot guarantee that each precursor will be fragmented in each run. In contrast, targeted proteomics aims to reproducibly and sensitively record a restricted number of precursor/fragment combinations in each run, based on pre-scheduled mass-to-charge and retention time windows. Read More

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http://dx.doi.org/10.1074/mcp.TIR118.001131DOI Listing
February 2019
6 Reads

Practical application of the sigma-metric run size nomogram for multistage bracketed statistical quality control analysis of eight enzymes.

Clin Chim Acta 2019 May 8;492:57-61. Epub 2019 Feb 8.

Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Background: A sigma-metric run size nomogram is used to recommend quality control (QC) strategies to reduce patient risks. Herein, we aimed to evaluate the sigma performance of 8 enzymes and apply multistage bracketed statistical QC (SQC).

Methods: Sigma performance of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), amylase (AMY), and lipase (LIP) were determined. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.006DOI Listing
May 2019
1 Read

Exposure-complaint relationships of various environmental odor sources in Styria, Austria.

Environ Sci Pollut Res Int 2019 Apr 8;26(10):9806-9815. Epub 2019 Feb 8.

Air Quality Control, Government of Styria, Landhausgasse 7, 8010, Graz, Austria.

In the planning and authorization process of industrial plants or agricultural buildings, it needs to be ensured that odor emissions do not annoy nearby residents in an unacceptable way. Previous studies have shown that odor-hour frequency is an important predictor for odor annoyance. However, odor-hour frequencies can be assessed for day and night separately. Read More

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http://link.springer.com/10.1007/s11356-019-04410-z
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http://dx.doi.org/10.1007/s11356-019-04410-zDOI Listing
April 2019
12 Reads

Hospital palliative care consult improves value-based purchasing outcomes in a propensity score-matched cohort.

Palliat Med 2019 Apr 7;33(4):452-456. Epub 2019 Feb 7.

1 Department of Internal Medicine, Christiana Care Health System, Newark, DE, USA.

Background:: Hospital-based palliative care consultation is consistently associated with reduced hospitalization costs and more importantly with improved patient quality of life. As healthcare systems move toward value-based purchasing rather than fee-for-service models, understanding how palliative care consultation is associated with value-based purchasing metrics can provide evidence for expanded health system support for a greater palliative care presence.

Aim:: To understand how a palliative care consultation impacts rates of patient readmission and hospital-acquired infections associated with value-based purchasing metrics. Read More

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http://dx.doi.org/10.1177/0269216318824270DOI Listing
April 2019
1 Read

Baseline mental status predicts happy patients after operative or non-operative treatment of adult spinal deformity.

J Spine Surg 2018 Dec;4(4):687-695

Department of Orthopaedic Surgery, NYU Langone Orthopaedic Hospital-New York Spine Institute, New York, NY, USA.

Background: The study is a retrospective review of a multi-institutional database, aiming to determine predictors of non-depressed, satisfied adult spinal deformity (ASD) patients with good self-image at 2-year follow-up (2Y). ASD significantly impacts a patients' psychological status. Following treatment, little is known about predictors of satisfied patients with high self-image and mental status. Read More

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http://dx.doi.org/10.21037/jss.2018.09.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330579PMC
December 2018
2 Reads