3,727 results match your criteria Quality Control Metrics


BoardION: real-time monitoring of Oxford Nanopore sequencing instruments.

BMC Bioinformatics 2021 May 13;22(1):245. Epub 2021 May 13.

Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, 91057, Evry, France.

Background: One of the main advantages of the Oxford Nanopore Technology (ONT) is the possibility of real-time sequencing. This gives access to information during the experiment and allows either to control the sequencing or to stop the sequencing once the results have been obtained. However, the ONT sequencing interface is not sufficient to explore the quality of sequencing data in depth and existing quality control tools do not take full advantage of real-time data streaming. Read More

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The clinical effects of sleep restriction therapy for insomnia: A meta-analysis of randomised controlled trials.

Sleep Med Rev 2021 Apr 21;58:101493. Epub 2021 Apr 21.

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, UK. Electronic address:

Sleep restriction therapy (SRT) is an established treatment for insomnia that has been used in clinical practise for over 30 y. It is commonly delivered as part of multicomponent cognitive-behavioural therapy (CBT-I) but has also been linked to beneficial effects as a standalone intervention. In order to quantify the efficacy of SRT we performed a comprehensive meta-analysis of randomised controlled trials (RCTs) comparing SRT to minimally active or non-active control groups. Read More

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An artificial intelligence that increases simulated brain-computer interface performance.

J Neural Eng 2021 May 13;18(4). Epub 2021 May 13.

Department of Electrical and Computer Engineering, University of California, Los Angeles, CA 90024, United States of America.

Brain-computer interfaces (BCIs) translate neural activity into control signals for assistive devices in order to help people with motor disabilities communicate effectively. In this work, we introduce a new BCI architecture that improves control of a BCI computer cursor to type on a virtual keyboard.Our BCI architecture incorporates an external artificial intelligence (AI) that beneficially augments the movement trajectories of the BCI. Read More

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Haplotype-resolved genome assembly enables gene discovery in the red palm weevil Rhynchophorus ferrugineus.

Sci Rep 2021 May 11;11(1):9987. Epub 2021 May 11.

National Center for Biotechnology,, King Abdulaziz City for Science and Technology, Riyadh, 11442, Saudi Arabia.

The red palm weevil Rhynchophorus ferrugineus (Coleoptera: Curculionidae) is an economically-important invasive species that attacks multiple species of palm trees around the world. A better understanding of gene content and function in R. ferrugineus has the potential to inform pest control strategies and thereby mitigate economic and biodiversity losses caused by this species. Read More

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The association between familial death in childhood or adolescence and subsequent substance use disorder: A systematic review and meta-analysis.

Addict Behav 2021 Mar 26;120:106936. Epub 2021 Mar 26.

Department of Psychology, Royal College of Surgeons in Ireland, Ireland. Electronic address:

Background: Exposure to childhood adversity has been linked to long-term negative mental health consequences in adulthood.

Purpose: This review examined the association between exposure to the death of a family member (i.e. Read More

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MoiRNAiFold: a novel tool for complex in silico RNA design.

Nucleic Acids Res 2021 May 6. Epub 2021 May 6.

Moirai Biodesign, c/ Baldiri Reixach s/n, Parc Científic de Barcelona (PCB), 08028 Barcelona, Spain.

Novel tools for in silico design of RNA constructs such as riboregulators are required in order to reduce time and cost to production for the development of diagnostic and therapeutic advances. Here, we present MoiRNAiFold, a versatile and user-friendly tool for de novo synthetic RNA design. MoiRNAiFold is based on Constraint Programming and it includes novel variable types, heuristics and restart strategies for Large Neighborhood Search. Read More

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The Endocrine Hospitalist: Enhancing the Quality of Diabetes Care.

J Diabetes Sci Technol 2021 May 6:19322968211007908. Epub 2021 May 6.

Johns Hopkins Community Physicians at Suburban Hospital, Bethesda, MD, USA.

The endocrine hospitalist and inpatient diabetes management team increases access to endocrinology consultations and improves glycemic control and quality metrics such as length of stay and hospital readmission. Enhanced glycemic care is needed in both academic and community hospital settings. Endocrine fellowship programs should implement endocrine hospitalist rotations with emphasis on training endocrine fellows to deliver fast-paced inpatient endocrine care. Read More

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Tongue image quality assessment based on a deep convolutional neural network.

BMC Med Inform Decis Mak 2021 May 5;21(1):147. Epub 2021 May 5.

Basic Medical College Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New Area, Shanghai, 201203, China.

Background: Tongue diagnosis is an important research field of TCM diagnostic technology modernization. The quality of tongue images is the basis for constructing a standard dataset in the field of tongue diagnosis. To establish a standard tongue image database in the TCM industry, we need to evaluate the quality of a massive number of tongue images and add qualified images to the database. Read More

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Estimating causes of out-of-hospital deaths in China: application of SmartVA methods.

Popul Health Metr 2021 May 4;19(1):25. Epub 2021 May 4.

Institute for Health Metrics and Evaluation, University of Washington, Seattle, USA.

Background: Most deaths in China occur at home, making it difficult to collect reliable cause of death (CoD) information. Verbal autopsy (VA) was applied using the SmartVA tool to a sample of home deaths in China to explore its feasibility as a means of improving the quality of CoD data.

Methods: The study was carried out in 22 districts in 9 provinces, located in north-east, central, and western areas of China during 2017 and 2018. Read More

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Isolation of Adult Human Astrocyte Populations from Fresh-frozen Cortex using Fluorescence-Activated Nuclei Sorting.

J Vis Exp 2021 Apr 16(170). Epub 2021 Apr 16.

Department of Pathology, Icahn School of Medicine at Mount Sinai; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai;

The complexity of human astrocytes remains poorly defined in primary human tissue, requiring better tools for their isolation and molecular characterization. Fluorescence-activated nuclei sorting (FANS) can be used to successfully isolate and study human neuronal nuclei (NeuN+) populations from frozen archival tissue, thereby avoiding problems associated with handling fresh tissue. However, efforts to similarly isolate astroglia from the non-neuronal (NeuN-) element are lacking. Read More

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On the relevance of modulation transfer function measurements in digital mammography quality control.

J Med Imaging (Bellingham) 2021 Mar 27;8(2):023505. Epub 2021 Apr 27.

KU Leuven, Department of Imaging and Pathology, Leuven, Belgium.

The relevance of presampling modulation transfer function (MTF) measurements in digital mammography (DM) quality control (QC) is examined. Two studies are presented: a case study on the impact of a reduction in MTF on the technical image quality score and analysis of the robustness of routine QC MTF measurements. In the first study, two needle computed radiography (CR) plates with identical sensitivities were used with differences in the 50% point of the MTF ( ) larger than the limiting value in the European guidelines ( change between successive measurements). Read More

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Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.

Cytotherapy 2021 May 10;23(5):373-380. Epub 2021 Apr 10.

Institute of Medical Biology and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address:

Mesenchymal stromal/stem cells (MSCs) have been widely tested against many diseases, with more than 1000 registered clinical trials worldwide. Despite many setbacks, MSCs have been approved for the treatment of graft-versus-host disease and Crohn disease. However, it is increasingly clear that MSCs exert their therapeutic functions in a paracrine manner through the secretion of small extracellular vesicles (sEVs) of 50-200 nm in diameter. Read More

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JEDi: java essential dynamics inspector - a molecular trajectory analysis toolkit.

BMC Bioinformatics 2021 May 1;22(1):226. Epub 2021 May 1.

Department of Physics and Optical Sciences, University of North Carolina Charlotte, 9201 University City Blvd, 28223, Charlotte, NC, USA.

Background: Principal component analysis (PCA) is commonly applied to the atomic trajectories of biopolymers to extract essential dynamics that describe biologically relevant motions. Although application of PCA is straightforward, specialized software to facilitate workflows and analysis of molecular dynamics simulation data to fully harness the power of PCA is lacking. The Java Essential Dynamics inspector (JEDi) software is a major upgrade from the previous JED software. Read More

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Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 - 2016.

Circulation 2021 Apr 30. Epub 2021 Apr 30.

Columbia University Irving Medical Center, New York City, NY.

Spending on cardiovascular disease and cardiovascular risk factors (cardiovascular spending) accounts for a significant portion of overall US healthcare spending. Our objective was to describe US adult cardiovascular spending patterns in 2016, changes from 1996 to 2016, and factors associated with changes over time. We extracted information on adult cardiovascular spending from the Institute for Health Metrics and Evaluation's disease expenditure project, which combines data on insurance claims, emergency department and ambulatory care visits, inpatient and nursing care facility stays, and drug prescriptions to estimate over 85% of all US healthcare spending. Read More

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Species-Specific Quality Control, Assembly and Contamination Detection in Microbial Isolate Sequences with AQUAMIS.

Genes (Basel) 2021 Apr 26;12(5). Epub 2021 Apr 26.

Department Biological Safety, German Federal Institute for Risk Assessment, 10589 Berlin, Germany.

Sequencing of whole microbial genomes has become a standard procedure for cluster detection, source tracking, outbreak investigation and surveillance of many microorganisms. An increasing number of laboratories are currently in a transition phase from classical methods towards next generation sequencing, generating unprecedented amounts of data. Since the precision of downstream analyses depends significantly on the quality of raw data generated on the sequencing instrument, a comprehensive, meaningful primary quality control is indispensable. Read More

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Cognitive Function and Whole-Brain MRI Metrics Are Not Associated with Mobility in Older Adults with Multiple Sclerosis.

Int J Environ Res Public Health 2021 Apr 16;18(8). Epub 2021 Apr 16.

Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Due to advances in disease-modifying medications and earlier management of comorbidities, adults with multiple sclerosis (MS) are living longer, and this coincides with the aging of the general population. One major problem among older adults with and without MS is limited mobility, a consequence of aging that often negatively affects quality of life. Identifying factors that contribute to mobility disability is needed to develop targeted rehabilitation approaches. Read More

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Design of Minimum Nonlinear Distortion Reconfigurable Antennas for Next-Generation Communication Systems.

Sensors (Basel) 2021 Apr 6;21(7). Epub 2021 Apr 6.

Department of Signal Theory and Communications (TSC), School of Telecommunications Engineering, Universitat Politècnica de Catalunya (UPC), Campus Nord, 08034 Barcelona, Spain.

Nonlinear effects in the radio front-end can degrade communication quality and system performance. In this paper we present a new design technique for reconfigurable antennas that minimizes the nonlinear distortion and maximizes power efficiency through the minimization of the coupling between the internal switching ports and the external feeding ports. As a nonlinear design and validation instance, we present the nonlinear characterization up to 50 GHz of a PIN diode commonly used as a switch for reconfigurable devices in the microwave band. Read More

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Change in Physical Performance Correlates with Decline in Quality of Life and Frailty Status in Head and Neck Cancer Patients Undergoing Radiation with and without Chemotherapy.

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.

Patient-reported quality of life (QoL) metrics, frailty status, and physical functioning are emerging concepts in head and neck cancer (HNC) with implications on both treatment decision-making and prognosis. The impact of treatment-related functional decline on QoL and frailty has not been well-characterized in HNC and was the focus of this investigation.

Methods: Patients who underwent radiation therapy for HNC from 2018 to 2020 were evaluated as a prospective observational cohort. Read More

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The effectiveness of social media and in-person interventions for low back pain conditions in nursing personnel (SMILE).

Nurs Open 2021 05 15;8(3):1220-1231. Epub 2020 Dec 15.

Health Metrics Research Center, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.

Aim: To compare two educational approaches to reduce low back pain in nurses.

Design: A community randomized controlled clinical trial.

Methods: Data were collected with two interventions and a control arm between August 2018 and January 2019. Read More

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SEVE project (Surgical Expertise Validity Evaluation) risk adjusted quality by standard data.

Cir Esp 2021 Apr 23. Epub 2021 Apr 23.

Imperial College University, London, UK.

The SEVE project (Surgical Expertise Validity Evaluation) is a collaborative effort of the AEC (Spanish Association of Surgeons) and the Section of Surgery of the European Union of Medical Specialists (UEMS) that aims to develop a model and an on line application that can be used to evaluate surgical complications. The aim is to identify the optimal results that can be obtained in each intervention, in order to present them as a reference for our usual practice (benchmarking). Read More

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Edge area metric complexity scoring of volumetric modulated arc therapy plans.

Phys Imaging Radiat Oncol 2021 Jan 6;17:124-129. Epub 2021 Mar 6.

Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.

Background And Purpose: Aperture-based complexity metrics have been suggested as a method to score complexity of volumetric modulated arc therapy (VMAT) plans. The purpose of this study was to evaluate the edge area metric (EAM) for clinical VMAT plans on a control point and treatment plan level.

Materials And Methods: EAM on a control point level was evaluated based on film measurements of 18 static beam openings originating from VMAT plans. Read More

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January 2021

Covid-19 Dynamic Monitoring and Real-Time Spatio-Temporal Forecasting.

Front Public Health 2021 8;9:641253. Epub 2021 Apr 8.

Center for Informatics, Federal University of Pernambuco, Recife, Brazil.

Periodically, humanity is often faced with new and emerging viruses that can be a significant global threat. It has already been over a century post-the Spanish Flu pandemic, and we are witnessing a new type of coronavirus, the SARS-CoV-2, which is responsible for Covid-19. It emerged from the city of Wuhan (China) in December 2019, and within a few months, the virus propagated itself globally now resulting more than 50 million cases with over 1 million deaths. Read More

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Impact of a pollution breach at a coke oven factory on asthma control in nearby vulnerable adults.

J Allergy Clin Immunol 2021 Apr 21. Epub 2021 Apr 21.

Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA. Electronic address:

Background: Previous studies relate sulfur dioxide (SO) exposure with asthma exacerbations. We utilized the University of Pittsburgh Asthma Institute registry (AIR) to study associations of asthma exacerbations between two geographically distinct adult asthma populations.

Objective: The objective was to examine if asthma symptoms worsened following a significant fire event that destroyed pollution control equipment at the largest Coke Works in the United States. Read More

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Best Practices in Structural Neuroimaging of Neurodevelopmental Disorders.

Neuropsychol Rev 2021 Apr 24. Epub 2021 Apr 24.

Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universitaet Dresden, Dresden, Germany.

Structural magnetic resonance imaging (sMRI) offers immense potential for increasing our understanding of how anatomical brain development relates to clinical symptoms and functioning in neurodevelopmental disorders. Clinical developmental sMRI may help identify neurobiological risk factors or markers that may ultimately assist in diagnosis and treatment. However, researchers and clinicians aiming to conduct sMRI studies of neurodevelopmental disorders face several methodological challenges. Read More

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Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator.

Br J Radiol 2021 Apr 29:20201011. Epub 2021 Apr 29.

Medical Physics Service, Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust, Hull, UK.

Objective: High levels of beam modulation complexity (MC) and monitor units (MU) can compromise the plan deliverability of intensity-modulated radiotherapy treatments. Our study evaluates the effect of three treatment planning system (TPS) parameters on MC and MU using different multi-leaf collimator (MLC) architectures.

Methods: 192 volumetric modulated arc therapy plans were calculated using one virtual prostate phantom considering three main settings: (1) three TPS-parameters (Convergence; Aperture Shape Controller, ASC; and Dose Calculation Resolution, DCR) selected from Eclipse v15. Read More

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Evaluation of early postoperative intravenous opioid rescue as a novel quality measure in patients who receive thoracic epidural analgesia: a retrospective cohort analysis and prospective performance improvement intervention.

BMC Anesthesiol 2021 Apr 19;21(1):120. Epub 2021 Apr 19.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.

Background: In this study, we explored the utility of intravenous opioid rescue analgesia in the post anesthesia care unit (PACU-OpResc) as a single marker of thoracic epidural analgesia (TEA) failure and evaluated the resource implications and quality improvement applications of this measure.

Methods: We performed a retrospective analysis of all TEA placements over a three-year period at a single academic medical center in Boston, Massachusetts. The study exposure was PACU-OpResc. Read More

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Patient Characteristics Associated With Readmission to 3 Neurology Services at an Urban Academic Center.

Neurohospitalist 2021 Jan 4;11(1):25-32. Epub 2020 Sep 4.

Department of Neurology, New York University Langone Health, New York, NY, USA.

Background And Purpose: Hospital 30-day readmissions in patients with primary neurological problems are not well characterized. We sought to determine patient characteristics associated with readmission across 3 different inpatient neurology services at New York University Langone Hospital.

Methods: We retrospectively reviewed all 30-day readmissions from the General Neurology, Epilepsy, and Stroke services at NYULH Brooklyn and Manhattan campuses from 2016-2017 and compared them to a random sample of non-readmitted neurology patients. Read More

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January 2021

Prediction of early childhood obesity with machine learning and electronic health record data.

Int J Med Inform 2021 Apr 9;150:104454. Epub 2021 Apr 9.

Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, USA; Department of Anesthesiology & Critical Care Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, USA.

Objective: This study compares seven machine learning models developed to predict childhood obesity from age > 2 to ≤ 7 years using Electronic Healthcare Record (EHR) data up to age 2 years.

Materials And Methods: EHR data from of 860,510 patients with 11,194,579 healthcare encounters were obtained from the Children's Hospital of Philadelphia. After applying stringent quality control to remove implausible growth values and including only individuals with all recommended wellness visits by age 7 years, 27,203 (50. Read More

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Comparison between MGI and Illumina sequencing platforms for whole genome sequencing.

Genes Genomics 2021 Apr 17. Epub 2021 Apr 17.

Personalized Genomic Medicine Research Center, KRIBB, 34141, Daejeon, South Korea.

Background: Illumina next generation sequencing (NGS) systems are the major sequencing platform in worldwide next-generation sequencing market. On the other hand, MGI Tech launched a series of new NGS equipment that promises to deliver high-quality sequencing data faster and at lower prices than Illumina's sequencing instruments.

Objective: In this study, we compared the performance of the two platform's major sequencing instruments-Illumina's NovaSeq 6000 and MGI's MGISEQ-2000 and DNBSEQ-T7-to test whether the MGISEQ-2000 and DNBSEQ-T7 sequencing instruments are also suitable for whole genome sequencing. Read More

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Dosimetric analysis of cervical cancer stage IIB patients treated with volumetric modulated arc therapy using plan uncertainty parameters module of Varian Eclipse treatment planning system.

Biomed Phys Eng Express 2021 Apr 28;7(3). Epub 2021 Apr 28.

Department of Radiation Oncology, Dr B L Kapur Memorial Hospital, Delhi, India.

. The present study aims to investigate the dosimetric and radiobiological impact of patient setup errors (PSE) on the target and organs at risk (OAR) of the cervix carcinoma stage IIB patients treated with volumetric-modulated arc therapy (VMAT) delivery technique using plan uncertainty parameters module of Varian Eclipse treatment planning system and in-house developed DVH Analyzer program.. Read More

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