1,086,776 results match your criteria Quality & Safety in Health Care[Journal]


[Modified Western Ontario and McMaster University Osteoarthritis Index Scale used in patients with knee osteoarthritis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):537-541

Department of Traditional Chinese Medicine, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150081, China.

To modify Western Ontario and McMaster University Osteoarthritis Index (WOMAC) for more accurate evaluation of patients with knee osteoarthritis in China,and its reliability and validity were measured. The WOMAC was modified through reviewing relevant literatures and practical survey.Total of 120 patients were enrolled in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.012DOI Listing
February 2019

[Comparative observation of thulium laser resection of the prostate-tangerine technique and transurethral resection of the prostate for the treatment of benign prostatic hyperplasia of various sizes].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):423-427

Department of Urology, Guizhou Provincial People's Hospital, Guiyang 550002, China.

To compare the efficiency and safety of thulium laser resection of the prostate-tangerine technique (TmLRP-TT) and transurethral resection of the prostate (TURP) for the treatment of benign prostatic hyperplasia (BPH) of various sizes. Clinical data of 249 BPH patients received TmLRP-TT or TURP were retrospectively collected. Patients were divided into small prostate group [prostate volume (PV)<40 ml], medium prostate group (40 ml≤PV<80 ml) and large prostate group (PV ≥ 80 ml) based on transrectal ultrasound (TRUS) results. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.008DOI Listing
February 2019

The self-perceptions of aging were an important factor associated with the quality of life in Chinese elderly with hypertension.

Psychogeriatrics 2019 Feb 20. Epub 2019 Feb 20.

Division of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: In China, quality of life (QOL) of the elderly with hypertension was lower than that of normal elderly and lower self-perceptions of aging (SPA) in the elderly with chronic diseases have been shown. Previous studies showed that SPA played a key role in QOL of the elderly. We hypothesised that SPA were associated with QOL in Chinese elderly with hypertension, with more negative SPA predicting lower QOL. Read More

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http://dx.doi.org/10.1111/psyg.12400DOI Listing
February 2019

Intensity-modulated radiation therapy dose prescription and reporting: Sum and substance of the International Commission on Radiation Units and Measurements Report 83 for veterinary medicine.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. Read More

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http://dx.doi.org/10.1111/vru.12722DOI Listing
February 2019

The Use of Mobile Educational Tools to Improve Antimicrobial Prescription for the Treatment of Acute Pyelonephritis in Pregnancy: A Retrospective Cross-sectional Study.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):97-101. Epub 2019 Feb 20.

Graduate Program in Medicine and Health Sciences, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

Objective:  To analyze the prescription of antimicrobial agents for pregnant women admitted into the obstetrics service who presented with acute pyelonephritis.

Methods:  Three cross-sectional studies were performed comparing the prescription of antimicrobials for pyelonephritis in pregnant women in the time periods evaluated (2010-2011: 99 patients evaluated; 2013: 116 patients evaluated; 2015: 107 patients evaluated), at the Hospital Fêmina, Porto Alegre, in the state of Rio Grande do Sul, Brazil. The analysis was performed before and after the promotion of an institutional protocol for the treatment of pyelonephritis during pregnancy, and on a third occasion after the introduction of a smartphone-based mobile educational tool. Read More

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http://dx.doi.org/10.1055/s-0039-1678590DOI Listing
February 2019
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Electronic Health Record Adoption and Nurse Reports of Usability and Quality of Care: The Role of Work Environment.

Appl Clin Inform 2019 Jan 20;10(1):129-139. Epub 2019 Feb 20.

Center for Health Outcomes and Policy Research, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, United States.

Background:  Despite evidence suggesting higher quality and safer care in hospitals with comprehensive electronic health record (EHR) systems, factors related to advanced system usability remain largely unknown, particularly among nurses. Little empirical research has examined sociotechnical factors, such as the work environment, that may shape the relationship between advanced EHR adoption and quality of care.

Objective:  The objective of this study was to examine the independent and joint effects of comprehensive EHR adoption and the hospital work environment on nurse reports of EHR usability and nurse-reported quality of care and safety. Read More

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http://dx.doi.org/10.1055/s-0039-1678551DOI Listing
January 2019

A Nationwide Analysis of Preoperative Planning on Operative Times and Postoperative Complications in Total Knee Arthroplasty.

J Knee Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Orthopedic Surgery, Lenox Hill Hospital, Northwell Health, New York, New York.

Compared with nonelective total knee arthroplasties (TKAs), elective procedures have more time for preoperative planning, which allows for potentially improved patient optimization, risk factor modification, and patient education. The purpose of this study was to (1) determine nationwide trends in operative times and (2) evaluate associations between surgery type, elective or nonelective, with respect to (a) operative times, (b) length of stay (LOS), (c) discharge dispositions, (d) 30-day postoperative complications, (e) reoperations, and (f) readmissions. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried for all primary TKAs performed between 2011 and 2016. Read More

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http://dx.doi.org/10.1055/s-0039-1677790DOI Listing
February 2019

["Crystal" and Pregnancy - The Preliminary Results of a Retrospective Study on the Course of Pregnancy and Delivery of Women Consuming Methamphetamine].

Z Geburtshilfe Neonatol 2019 Feb 20. Epub 2019 Feb 20.

Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus Dresden, Dresden.

Introduction: It can be observed that there is an increase in the methamphetamine (MA) consumption in Saxony (Federal Republic of Germany). There is so far no data available in German speaking countries about the risk of MA consumption in pregnancy or delivery.

Methods: The data from all pregnant women who were examined or delivered at the Clinic for Obstetrics and Gynaecology between 2010-2015 were retrospectively searched for MA consumption. Read More

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http://dx.doi.org/10.1055/a-0831-3642DOI Listing
February 2019

Hemodynamic Response of the Three Macular Capillary Plexuses in Dark Adaptation and Flicker Stimulation Using Optical Coherence Tomography Angiography.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):694-703

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States.

Purpose: To assess retinal microvascular reactivity during dark adaptation and the transition to ambient light and after flicker stimulation using optical coherence tomography angiography (OCTA).

Methods: Fifteen eyes of 15 healthy participants were dark adapted for 45 minutes followed by OCTA imaging in the dark-adapted state. After 5 minutes of normal lighting, subjects underwent OCTA imaging. Read More

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http://dx.doi.org/10.1167/iovs.18-25478DOI Listing
February 2019

The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality.

Aging (Albany NY) 2019 Feb 20. Epub 2019 Feb 20.

State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, Jiangsu, P.R. China.

Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively, and are essential for ATP generation. Read More

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http://dx.doi.org/10.18632/aging.101802DOI Listing
February 2019

Unexpected term NICU admissions: a marker of obstetrical care quality?

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard University, Boston, MA.

Background: Unexpected admissions of term neonates to the neonatal intensive care unit (NICU) and unexpected postnatal complications have been proposed as neonatal-focused quality metrics for intrapartum care. Previous studies have noted significant variation in overall hospital NICU admission rates; however, little is known about the influence of obstetric practices on these rates or whether variation among unanticipated admissions in low risk, term neonates can be attributed to systemic hospital practices.

Objective: To examine the relative effects of patient characteristics and intrapartum events on unexpected NICU admissions, and to quantify the between-hospital variation in NICU admission rates among this group of neonates. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.001DOI Listing
February 2019

Mechanisms of Sensory Discrimination: Insights from Drosophila Olfaction.

Annu Rev Biophys 2019 Feb 20. Epub 2019 Feb 20.

Centre for Neural Circuits and Behavior, University of Oxford , Oxford OX1 3SR, United Kingdom; email:

All an animal can do to infer the state of its environment is to observe the sensory-evoked activity of its own neurons. These inferences about the presence, quality, or similarity of objects are probabilistic and inform behavioral decisions that are often made in close to real time. Neural systems employ several strategies to facilitate sensory discrimination: Biophysical mechanisms separate the neuronal response distributions in coding space, compress their variances, and combine information from sequential observations. Read More

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http://dx.doi.org/10.1146/annurev-biophys-052118-115655DOI Listing
February 2019

Acoustic Pattern Recognition and Courtship Songs: Insights from Insects.

Annu Rev Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Princeton Neuroscience Institute , Princeton University, Princeton, New Jersey 08544, USA; email:

Across the animal kingdom, social interactions rely on sound production and perception. From simple cricket chirps to more elaborate bird songs, animals go to great lengths to communicate information critical for reproduction and survival via acoustic signals. Insects produce a wide array of songs to attract a mate, and the intended receivers must differentiate these calls from competing sounds, analyze the quality of the sender from spectrotemporal signal properties, and then determine how to react. Read More

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http://dx.doi.org/10.1146/annurev-neuro-080317-061839DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

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http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019

Thickness Tunable Wedding-Cake-like MoS Flakes for High-Performance Optoelectronics.

ACS Nano 2019 Feb 22. Epub 2019 Feb 22.

Center for Nanochemistry (CNC), Academy for Advanced Interdisciplinary Studies, Department of Materials Science and Engineering, College of Engineering , Peking University , Beijing 100871 , People's Republic of China.

Atomically thin transition-metal dichalcogenides (TMDCs) have received substantial interest due to their typical thickness-dependent optical and electronic properties and related applications in optoelectronics. However, the large-scale, thickness-tunable growth of such materials is still challenging. Herein, we report a fast growth of thickness-tunable wedding-cake-like MoS flakes on 6-in. Read More

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http://dx.doi.org/10.1021/acsnano.9b00277DOI Listing
February 2019

Genitourinary cancer patients have worse baseline semen parameters than healthy sperm bankers.

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Massachusetts General Hospital, Boston, MA, USA.

Background: While the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood.

Objectives: To determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers.

Materials And Methods: Retrospective database review of de-identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: 'future use' (e. Read More

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http://dx.doi.org/10.1111/andr.12602DOI Listing
February 2019

Disparities in the delivery of pediatric oncology nursing care by country income classification: International survey results.

Pediatr Blood Cancer 2019 Feb 20:e27663. Epub 2019 Feb 20.

Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: In 2014, a task force of the International Society of Paediatric Oncology (SIOP) Paediatric Oncology in Developing Countries Nursing Workgroup published six baseline standards to provide a framework for pediatric oncology nursing care in low- and lower-middle income countries (L/LMIC). We conducted an international survey in 2016-2017 to examine the association between country income level and nurses' resporting of conformity to the standards at their respective institutions.

Procedure: Data from a cross-sectional web-based survey completed by nurses representing 54 countries were analyzed (N = 101). Read More

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http://dx.doi.org/10.1002/pbc.27663DOI Listing
February 2019

Alpha lipoic acid reverses the negative effect of LPS on mouse spermatozoa and developmental competence of resultant embryos in vitro.

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Background: Reproductive toxicity of lipopolysaccharide (LPS) on spermatozoa is well established.

Objective: The aim of the present study was to show the potential benefits of alpha lipoic acid (ALA) as a strong antioxidant in alleviating the reproductive toxicity of LPS.

Materials And Methods: Sperm cells and cumulus-oocyte complexes (COCs) were collected from healthy NMRI mice (body weights ranged from 25 to 35 g, 100 females and 200 males). Read More

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http://dx.doi.org/10.1111/andr.12596DOI Listing
February 2019

WSe Photovoltaic Device Based on Intramolecular p-n Junction.

Small 2019 Feb 20:e1805545. Epub 2019 Feb 20.

Key Laboratory of Space Active Opto-Electronics Technology, and State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai, 200083, China.

High quality p-n junctions based on 2D layered materials (2DLMs) are urgent to exploit, because of their unique properties such as flexibility, high absorption, and high tunability which may be utilized in next-generation photovoltaic devices. Based on transfer technology, large amounts of vertical heterojunctions based on 2DLMs are investigated. However, the complicated fabrication process and the inevitable defects at the interfaces greatly limit their application prospects. Read More

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http://dx.doi.org/10.1002/smll.201805545DOI Listing
February 2019

A multi-institutional evaluation of machine performance check system on treatment beam output and symmetry using statistical process control.

J Appl Clin Med Phys 2019 Feb 20. Epub 2019 Feb 20.

Queensland University of Technology, Brisbane, QLD, Australia.

Background: The automated and integrated machine performance check (MPC) tool was verified against independent detectors to evaluate its beam uniformity and output detection abilities to consider it suitable for daily quality assurance (QA).

Methods: Measurements were carried out on six linear accelerators (each located at six individual sites) using clinically available photon and electron energies for a period up to 12 months (n = 350). Daily constancy checks on beam symmetry and output were compared against independent devices such as the SNC Daily QA 3, PTW Farmer ionization chamber, and SNC field size QA phantom. Read More

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http://dx.doi.org/10.1002/acm2.12547DOI Listing
February 2019

Homelessness among youth who identify as LGBTQ+: A systematic review.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

School of Nursing and Midwifery, Queen's University Belfast, Northern Ireland, United Kingdom.

Aims And Objectives: To explore homelessness among lesbian, gay, bisexual, transgender, queer/questioning plus (LGBTQ+) youth and to identify their support and care requirements.

Background: LGBTQ+ youth face many health and societal challenges including issues related to homelessness.

Design: A systematic review of qualitative, quantitative and mixed methods studies. Read More

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http://dx.doi.org/10.1111/jocn.14818DOI Listing
February 2019

Evaluation of X-ray tomography contrast agents: A review of production, protocols, and biological applications.

Microsc Res Tech 2019 Feb 20. Epub 2019 Feb 20.

School of Engineering, London South Bank University, London, United Kingdom.

X-ray computed tomography is a strong tool that finds many applications both in medical applications and in the investigation of biological and nonbiological samples. In the clinics, X-ray tomography is widely used for diagnostic purposes whose three-dimensional imaging in high resolution helps physicians to obtain detailed image of investigated regions. Researchers in biological sciences and engineering use X-ray tomography because it is a nondestructive method to assess the structure of their samples. Read More

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http://dx.doi.org/10.1002/jemt.23225DOI Listing
February 2019
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Maternal Health Outcomes for Incarcerated Women: A Scoping Review.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Dalhousie University's, School of Nursing, Associate Dean Academic, , Dalhousie, University's Faculty of Health; Nurse, IWK Health Centre, Halifax, Nova Scotia.

Aims And Objectives: This scoping review uses intersectional feminism to inform a systematic synthesis of what is known about the maternal health outcomes of incarcerated women.

Background: Despite rising imprisonment of women, there is a lack of research, from a feminist perspective, on perinatal health outcomes among incarcerated women.

Design: Systematic scoping review using the Joanna Briggs Institute scoping review methodology. Read More

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http://doi.wiley.com/10.1111/jocn.14837
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http://dx.doi.org/10.1111/jocn.14837DOI Listing
February 2019
1 Read

Effects of a safe transition program for discharged patients with high unmet needs.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, Republic of Korea.

Aims And Objectives: To examine the effects of the Patient-Oriented Safe Transition program on 30-day unplanned readmissions and emergency department visits, medical costs, caregiver burden, and patient health-related quality of life.

Background: With the success of hospitals' quality improvement efforts, the number of discharged patients has been increasing. Successful management of discharged patients is needed in order to reduce unplanned readmissions and to improve patient health outcomes. Read More

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http://doi.wiley.com/10.1111/jocn.14831
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http://dx.doi.org/10.1111/jocn.14831DOI Listing
February 2019
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Nursing people with intellectual disability and dementia experiencing pain: An integrative review.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Nursing and Midwifery, University of Limerick, Ireland.

Aim: To explore the current evidence of nurses caring for people with Intellectual Disability and dementia who experience pain.

Background: People with intellectual disability are ageing and are experiencing age related health conditions including dementia and conditions associated with pain, but at an earlier age. Addressing the needs of people with intellectual disability who develop dementia is a new challenge for nurses. Read More

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http://dx.doi.org/10.1111/jocn.14834DOI Listing
February 2019

Flawed self-assessment in hand-hygiene: a major contributor to infections in clinical practice?

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Mathematics, Physics and Informatics, Comenius University in Bratislava, Mlynska dolina F1, 842 48, Bratislava, Slovak Republic.

Aim: To assess the quality of self-assessment and the attitude of healthcare workers (HCWs) to hand hygiene (HH) as possible factors of unsatisfactory HH compliance in clinical practice.

Background: Non-compliance of hand hygiene causes healthcare-acquired infections (HAI) in patients. It is assumed that hand hygiene-related infections make up approximately 80% of all infections in clinical practice. Read More

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http://dx.doi.org/10.1111/jocn.14823DOI Listing
February 2019

Central venous line-related thromboembolism is common in children with non-high risk acute lymphoblastic leukaemia.

Acta Paediatr 2019 Feb 20. Epub 2019 Feb 20.

Department of Paediatric Haematology and Oncology, Oslo University Hospital, Norway.

Children with acute lymphoblastic leukaemia face increased risks of thromboembolism, and major risk factors for this serious treatment-related toxicity are central venous lines, asparaginase and steroids. Central venous lines have become standard care in paediatric oncology, facilitating therapy and improving patients' quality of life. However, up to half of the children with acute lymphoblastic leukaemia will develop asymptomatic central venous line-related thromboembolism. Read More

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http://dx.doi.org/10.1111/apa.14757DOI Listing
February 2019

Caring for aged people: The influence of personal resilience and workplace climate on 'doing good' and 'feeling good'.

J Adv Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Management, Monash University, Melbourne, Victoria, Australia.

Aims: This study examines the impact of personal resilience on the well-being of care workers and how perceptions of the quality of care provided and the social climate in the organization influences this relationship. We examine quality of patient care as both a mediating and outcome variable to better understand if 'doing good' (quality of care) leads to 'feeling good' (personal well-being).

Background: As an ageing population and the care for the older people has become an increasing challenge to many societies, developing and retaining a professional care workforce through effective management is vital in providing care services. Read More

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http://dx.doi.org/10.1111/jan.13935DOI Listing
February 2019

Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta-analysis and systematic review.

J Neurochem 2019 Feb 20. Epub 2019 Feb 20.

Spine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Spinal cord injury (SCI) is a devastating condition that has few treatment options. Riluzole, a sodium channel blocker used to treat amyotrophic lateral sclerosis, has been initially trialed in human SCI. We performed a systematic review to critically assess the efficacy of riluzole in locomotor recovery and damage extension in SCI rat models, and the potential for clinical translation. Read More

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http://dx.doi.org/10.1111/jnc.14686DOI Listing
February 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant non-small cell lung cancer.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China.

Oncogenic KRAS is considered a promising target for anti-cancer therapy. However, direct pharmacological strategies targeting KRAS-driven cancers remained unavailable. The prenyl-binding protein PDEδ, a transporter of KRAS, has been identified as a potential target for pharmacological inhibitor by selectively binding to its prenyl-binding pocket, impairing oncogenic KRAS signaling pathway. Read More

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http://dx.doi.org/10.1002/ijc.32222DOI Listing
February 2019

Melatonin supplementation during in vitro maturation of oocyte enhances subsequent development of bovine cloned embryos.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Basic Veterinary Sciences, Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Ministry of Agriculture, Yangling, Shaanxi, China.

Oocyte quality, which is directly related to reprogramming competence, is a major important limiting factor in animal cloning efficiency. Compared with oocytes matured in vivo, in vitro matured oocytes exhibit lower oocyte quality and reprogramming competence primarily because of their higher levels of reactive oxygen species. In this study, we investigate whether supplementing the oocyte maturation medium with melatonin, a free radical scavenger, could improve oocyte quality and reprogramming competence. Read More

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http://dx.doi.org/10.1002/jcp.28357DOI Listing
February 2019
1 Read

[Sustainable development goals and mental health].

Vertex 2018 Nov;XXIX(142):300-303

Centre for Global Mental Health, King's College London, Institute of Psychiatry.

In 2015, the United Nations Sustainable Development Goals (SDGs) set the course for a more equitable distribution of resources globally. For the first time in history, this collective global commitment explicitly included mental health-related objectives, and manifested them as targets in the health SDG 3. This represents a unique opportunity to increase coverage and quality of services, especially in low- and middle-income countries, in which the current treatment gap surpasses 80% even for the most severe disorders. Read More

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November 2018

Supported employment: Meta-analysis and review of randomized controlled trials of individual placement and support.

PLoS One 2019 20;14(2):e0212208. Epub 2019 Feb 20.

Human Flourishing Program, The Institute for Quantitative Social Science, Harvard University, Cambridge, MA, United States of America.

Supported employment is a treatment whereby those with severe mental illness (or other disabilities) receive aid searching for competitive employment and mental health (or other) treatments concurrently. The most popular implementation of supported employment is individual placement and support (IPS). We conducted meta-analytic analyses of the randomized controlled trials of IPS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212208PLOS
February 2019

Kaposi's sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment.

PLoS Pathog 2019 Feb 20;15(2):e1007596. Epub 2019 Feb 20.

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.

Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses evade nuclear RNA decay remains largely unknown. The multifunctional Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 (Mta) protein is required for the nuclear stability of viral transcripts. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007596DOI Listing
February 2019

A multifactorial approach of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables affecting the scholastic achievement in Chilean students: An eight- year follow-up study.

PLoS One 2019 20;14(2):e0212279. Epub 2019 Feb 20.

Laboratory of Nutrition and Neurological Sciences, Human Nutrition Area, Institute of Nutrition and Food Technology Dr. Fernando Monckeberg Barros (INTA), University of Chile, Santiago, Chile.

The aim of this study was to quantitate the relative impact of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables on the results of the 2009 Quality Education Measurement System (SIMCE) tests of language and mathematics for scholastic achievement (SA) applying a multifactorial approach, in school-age children of the 2010 5th elementary school grade (5ESG) and of the 1st grade of high school (1HSG). The purposes were: i) to test the hypothesis that intellectual ability, the level of SA of the educational establishments in the 2009 SIMCE tests, sex, parental schooling levels, and head circumference-for-age Z-score are the most relevant parameters associated with 2009 SIMCE outcomes; ii) to determine the predictive ability of the 2009 SIMCE results in determining the 2013 SIMCE outcomes for the 2010 5ESG cohort (when they graduated from elementary school, 8th grade) and for determining the 2013 University Selection Test (PSU) outcomes for the 2010 1HSG group (for university admission, when they graduated from high school, 4th grade); iii) to determine the association between the 2009 SIMCE results with the 2017 PSU outcomes for the 2010 5ESG group (for university admission, when they graduated from high school, 4th grade). A representative, proportional and stratified sample of 33 schools of the Metropolitan Region of Chile was randomly chosen. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212279PLOS
February 2019

Pesticide distribution and depletion kinetic determination in honey and beeswax: Model for pesticide occurrence and distribution in beehive products.

PLoS One 2019 20;14(2):e0212631. Epub 2019 Feb 20.

Department of Toxicology, Kimron Veterinary Institute, Bet Dagan, Israel.

Beehive products such as honey, beeswax and recently pollen have been regarded for many years as appropriate sentinels for environmental pesticide pollutions. However, despite yearly application of hundreds of approved pesticides in agricultural fields, only a minor fraction of these organic compounds were actually detected in honey and beeswax samples. This observation has led us to question the general suitability of beehive products as a sentinel for synthetic organic pesticides applied in the field. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212631PLOS
February 2019

The risk factors for diabetic peripheral neuropathy: A meta-analysis.

PLoS One 2019 20;14(2):e0212574. Epub 2019 Feb 20.

Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). Read More

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February 2019

High quality process of care increases one-year survival after acute myocardial infarction (AMI): A cohort study in Italy.

PLoS One 2019 20;14(2):e0212398. Epub 2019 Feb 20.

Department of Epidemiology of Lazio Regional Health Service, Rome, Italy.

Background: The relationship between guideline adherence and outcomes in patients with acute myocardial infarction (AMI) has been widely investigated considering the emergency, acute, post-acute phases separately, but the effectiveness of the whole care process is not known.

Aim: The study aim was to evaluate the effect of the multicomponent continuum of care on 1-year survival after AMI.

Methods: We conducted a cohort study selecting all incident cases of AMI from health information systems during 2011-2014 in the Lazio region. Read More

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February 2019

Practical approaches to automated digital image analysis of Ki-67 labeling index in 997 breast carcinomas and causes of discordance with visual assessment.

PLoS One 2019 20;14(2):e0212309. Epub 2019 Feb 20.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

The Ki-67 labeling index (LI) is an important prognostic factor in breast carcinoma. The Ki-67 LI is traditionally calculated via unaided microscopic estimation; however, inter-observer and intra-observer variability and low reproducibility are problems with this visual assessment (VA) method. For more accurate assessment and better reproducibility with Ki-67 LI, digital image analysis was introduced recently. Read More

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February 2019

Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity.

PLoS One 2019 20;14(2):e0212436. Epub 2019 Feb 20.

Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain.

Objectives: To study the association of different components of physical fitness [flexibility, muscle strength and cardiorespiratory fitness (CRF)] and a clustered fitness score with health-related quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and to analyze whether participants with high fitness level have better HRQoL.

Methods: This cross-sectional study included 70 women with SLE (aged 42.5; SD 13. Read More

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February 2019

Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis.

PLoS One 2019 20;14(2):e0211228. Epub 2019 Feb 20.

Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHLN), CAML, Centro Cardiovascular da Universidade de Lisboa-CCUL, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal.

Introduction: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction.

Methods: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials. Read More

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February 2019
3.234 Impact Factor

Surgical management of intraocular lens dislocation: A meta-analysis.

PLoS One 2019 20;14(2):e0211489. Epub 2019 Feb 20.

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Purpose: To compare the efficacy and safety of intraocular lens (IOL) repositioning and IOL exchange for the treatment of patients with IOL dislocation.

Methods: We systematically searched for relevant publications in English or Chinese in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, China Biology Medicine Database, China National Knowledge Infrastructure Database and grey literature sources. Read More

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February 2019

Cost of illness and program of dengue: A systematic review.

PLoS One 2019 20;14(2):e0211401. Epub 2019 Feb 20.

Faculty of Pharmacy, Federal University of Goiás, Goiás, Brazil.

Background: Studies on dengue related to the cost of illness and cost of the program are factors to describe the economic burden of dengue, a neglected disease that has global importance in public health. These studies are often used by health managers in optimizing financial resources. A systematic review of studies estimating the cost of dengue was carried out, comparing the costs between the studies and examining the cost drivers regarding the methodological choices. Read More

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February 2019

Soil health pilot study in England: Outcomes from an on-farm earthworm survey.

PLoS One 2019 20;14(2):e0203909. Epub 2019 Feb 20.

Sustainable Agricultural Systems Department, Rothamsted Research, Harpenden, United Kingdom.

Earthworms are primary candidates for national soil health monitoring as they are ecosystem engineers that benefit both food production and ecosystem services associated with soil security. Supporting farmers to monitor soil health could help to achieve the policy aspiration of sustainable soils by 2030 in England; however, little is known about how to overcome participation barriers, appropriate methodologies (practical, cost-effective, usefulness) or training needs. This paper presents the results from a pilot #60minworms study which mobilised farmers to assess over >1300 ha farmland soils in spring 2018. Read More

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February 2019

Identifying indicators of aesthetics in the Great Barrier Reef for the purposes of management.

PLoS One 2019 20;14(2):e0210196. Epub 2019 Feb 20.

Pollinate, Sydney, New South Wales, Australia.

The aesthetic appreciation of natural places is one of the most fundamental ways in which people relate to their environment. It provides wellbeing, an opportunity for recreation and reflection, a sense of place, and cultural enrichment. It also motivates people to take care of natural places and to conserve them for current and future appreciation. Read More

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February 2019

Moderate plant water stress improves larval development, and impacts immunity and gut microbiota of a specialist herbivore.

PLoS One 2019 20;14(2):e0204292. Epub 2019 Feb 20.

Organismal and Evolutionary Biology Research Programme, University of Helsinki, Helsinki, Finland.

While host plant drought is generally viewed as a negative phenomenon, its impact on insect herbivores can vary largely depending on the species involved and on the intensity of the drought. Extreme drought killing host plants can clearly reduce herbivore fitness, but the impact of moderate host plant water stress on insect herbivores can vary, and may even be beneficial. The populations of the Finnish Glanville fritillary butterfly (Melitaea cinxia) have faced reduced precipitation in recent years, with impacts even on population dynamics. Read More

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February 2019

Virtual Reality-Assisted Pain, Anxiety, and Anger Management in the Emergency Department.

Telemed J E Health 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Emergency Medicine and School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia.

Study Objective: Pain management in emergency department (ED) patients is challenging. Although both pharmacological and nonpharmacological therapies exist, they are often suboptimal. Immersive virtual reality (VR) uses distraction and possible other methods to reduce perceptions of pain. Read More

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http://dx.doi.org/10.1089/tmj.2018.0273DOI Listing
February 2019

An Exploration of Useful Telemedicine-Based Resources for Clinical Research.

Telemed J E Health 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Psychiatry and Behavioral Sciences, Biomedical Informatics Center, College of Medicine, Medical University of South Carolina, Charleston, South Carolina.

Background: Clinical trials are key to ensuring high-quality, effective, and safe health care interventions, but there are many barriers to their successful and timely implementation. Difficulties with participant recruitment and enrollment are largely affected by difficulties with obtaining informed consent. Teleconsent is a telemedicine- based approach to obtaining informed consent and offers a unique solution to limitations of traditional consent approaches. Read More

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http://dx.doi.org/10.1089/tmj.2018.0221DOI Listing
February 2019

Evaluating a Solely Mechanical Articulating Laparoscopic Device: A Prospective Randomized Crossover Study.

J Laparoendosc Adv Surg Tech A 2019 Feb 20. Epub 2019 Feb 20.

3 Department of Surgery, Michigan Medicine, Ann Arbor, Michigan.

Background: The FlexDex (FD) is a solely mechanical articulating device that combines the functionality of robotic surgery with the relative low cost and simplicity of laparoscopy. We sought to evaluate the performance of first-time FD users while performing a simple suture task at locations of varying degrees of difficulty.

Study Design: A prospective, randomized crossover study was performed comparing the FD to standard laparoscopy (SL). Read More

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http://dx.doi.org/10.1089/lap.2018.0539DOI Listing
February 2019
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