1,069,675 results match your criteria Quality & Safety in Health Care[Journal]


Quality of Bowel Preparation for Colonoscopy in Patients with a History of Abdomino-Pelvic Surgery: Retrospective Cohort Study.

Yonsei Med J 2019 Jan;60(1):73-78

Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Purpose: Prior abdomino-pelvic (AP) surgery makes colonoscopy difficult and can affect bowel preparation quality. However, bowel preparation quality has been found to vary according to prior AP surgery type. We examined the relationship of prior AP surgery type with bowel preparation quality in a large-scale retrospective cohort. Read More

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January 2019

Overcoming the challenges of pen-side molecular diagnosis of African swine fever to support outbreak investigations under field conditions.

Transbound Emerg Dis 2018 Dec 16. Epub 2018 Dec 16.

National Veterinary Institute, Uppsala, Sweden.

African swine fever (ASF) is a devastating disease of pigs. Without a vaccine, early detection and rapid diagnosis of ASF is a crucial step towards effective disease control. In many countries where ASF is endemic, laboratory infrastructure including sampling and sample shipment is inadequate, and a rapid laboratory confirmation would require that the diagnosis is performed at regional laboratories close to the pig farms of concern, or even at the farm-side. Read More

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December 2018

Dementia-friendly community initiatives: An integrative review.

J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.

University of Canberra, 3. Stephen Neville.

Aim: To synthesise international research conducted on dementia-friendly community initiatives.

Background: The number of people living with dementia is increasing as a result of population ageing. Impairments related to neurological changes, together with environmental challenges result in disability for people who have dementia. Read More

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December 2018

Shoulder symptoms and quality of life impact of limited neck dissection after de-intensified chemoradiotherapy: Secondary analysis of two prospective trials.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill, North Carolina.

Background: We investigated the quality of life (QOL) impact of post-radiation therapy (RT) superselective/selective neck dissection after de-intensified chemoradiation for human papillomavirus-associated oropharynx cancer.

Methods: A total of 147 patients received 60 Gy and weekly low-dose cisplatin on two phase 2 trials with planned post-RT neck dissection or surveillance positron emission tomography with neck dissection reserved for salvage. UW-QOL Shoulder Score, EORTC H&N-35, and EAT-10 were assessed. Read More

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December 2018

A new approach of assessing patient safety aspects in routine practice using the example of "doctors handwritten prescriptions".

J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.

Research Unit for Safety in Health, c/o Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Austria.

Aims And Objectives: The aim of this study was to test the method of self- and external assessment as a feedback system to decrease illegibility and incorrectness of handwritten prescriptions and to reduce additional workload for nursing staff.

Background: Illegibility and incorrectness of handwritten prescriptions occur very often and are the most crucial factors affecting patient safety.

Design: Self- versus external assessment using a 15 items checklist. Read More

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December 2018

Subconjunctival draining minimally-invasive glaucoma devices for medically uncontrolled glaucoma.

Cochrane Database Syst Rev 2018 Dec 16;12:CD012742. Epub 2018 Dec 16.

Ophthalmology, Nottingham University Hospital, Derby Road, Nottingham, UK, NG7 2UH.

Background: Glaucoma is a leading cause of irreversible blindness. Subconjunctival draining minimally-invasive glaucoma devices such as the Xen gelatin implant and InnFocus stent have been introduced as a treatment to prevent glaucoma progressing.These implants provide a channel to allow aqueous humour from the anterior chamber of the eye to drain into the subconjunctival space on the surface of the eye thus reducing intraocular pressure (IOP) and mimicking the mechanism of the most commonly undertaken glaucoma surgery, trabeculectomy. Read More

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December 2018

A Multi-Model Framework to Estimate Perfusion Parameters Using Contrast-Enhanced Ultrasound Imaging.

Med Phys 2018 Dec 16. Epub 2018 Dec 16.

Department of Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Purpose: Contrast-enhanced ultrasound imaging (CEUS) has expanded the diagnostic potential of ultrasound by enabling real-time imaging and quantification of tissue perfusion. Several perfusion models and curve fitting methods have been developed to quantify the temporal behavior of tracer signal and standardize perfusion quantification. While the least-squares approach has traditionally been applied for curve-fitting, it can be inadequate for noisy and complex data. Read More

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December 2018

Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line.

Cell Mol Neurobiol 2018 Dec 15. Epub 2018 Dec 15.

State Key Laboratory Cultivation Base For TCM Quality and Efficacy, School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.

Retinoic acid-induced 14 is a developmentally regulated gene induced by retinoic acid and is closely associated with NIK/NF-κB signaling. In the present study, we examined the effect of RAI14 on mTOR-mediated glial inflammation in response to inflammatory factors and chemical ischemia. A U87 cell model of LPS- and TNF-α-induced inflammation was used to investigate the role of RAI14 in glial inflammation. Read More

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December 2018

The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Shanghai Taiyin Biotech Co., Ltd., Shanghai, 201203, China.

Hyperosmolality has been commonly investigated due to its effects on the production and quality characteristics of monoclonal antibodies (mAbs) produced in CHO cell fed-batch cultures. However, the application of hyperosmolality at different times and its effect on biopotency have seldom been researched, especially in perfusion culture. In our study, different degrees of hyperosmolality induced by sodium chloride were investigated in anti-IgE rCHO cell fed-batch cultures and anti-CD52 rCHO cell perfusion cultures during the initial and stable phases. Read More

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December 2018

Trials with proxy-reported outcomes registered on the Australian New Zealand Clinical Trials Registry (ANZCTR).

Qual Life Res 2018 Dec 15. Epub 2018 Dec 15.

Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, USA.

Aims: A proxy is someone other than a patient who reports a patient's outcomes as if they are the patient. Due to known discordance with patient reports, proxies are often not recommended in clinical trials; however, proxies may be needed in certain research contexts. We aimed to identify and describe trials registered on the Australian New Zealand Clinical Trials Registry (ANZCTR) with proxy-reported endpoints. Read More

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December 2018

Influence of patient-specific anatomy on medical computed tomography and risk evaluation of minimally invasive surgery at the otobasis.

Eur Arch Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.

Department of Otorhinolaryngology, University Hospital Duesseldorf, Duesseldorf, Germany.

Purpose: With the increasing use of new minimally invasive approaches in temporal bone surgery, the need arises for evaluation of the risk of injury to sensitive anatomical structures. The factors that influence the measurement uncertainty (variation in representation of position and shape of anatomical structures) of imaging are of relevance. We investigate the effect of patients' anatomy on the measurement uncertainty of medical CT. Read More

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December 2018

Efficacy of allergen-blocker mechanical barrier gel on symptoms and quality of life in patients with allergic rhinitis.

Eur Arch Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pediatric Immunology and Allergy, Dokuz Eylul University, Izmir, Turkey.

Propose: Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last two decades, the efficiency of barrier-enforcing measures in AR has been investigated. In this study, we aimed to evaluate the effect of allergen-blocker mechanical barrier gel (MBG) (AlerjiSTOP) treatment on symptoms and quality of life score (QoLS) in patients with seasonal and perennial allergic rhinitis. Read More

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December 2018
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Annual Injection of Zoledronic Acid Improves Bone Status in Children with Cerebral Palsy and Rett Syndrome.

Calcif Tissue Int 2018 Dec 15. Epub 2018 Dec 15.

Centre de référence des erreurs innées du métabolisme, Hôpital d'Enfants, CHRU Nancy, Nancy, France.

Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. Read More

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December 2018

Endodontic sealers based on calcium silicates: a systematic review.

Odontology 2018 Dec 15. Epub 2018 Dec 15.

Central Interdisciplinary Ambulance in the School of Dentistry, Albert-Schweitzer-Campus 1, Building W 30, 48149, Münster, Germany.

Recently, sealers based on calcium silicates were developed as a new class of endodontic sealers. Inspired by the excellent sealing ability and biocompatibility of calcium silicate-based cements, these sealers establish a biological point of view on the obturation of root canals. No longer, the bacteria-tight seal against reinfection of the root canal is the only goal of root canal obturation. Read More

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December 2018

Consensus Statement of the Italian Society of Colorectal Surgery (SICCR): management and treatment of complete rectal prolapse.

Tech Coloproctol 2018 Dec 15. Epub 2018 Dec 15.

Department of Colorectal Surgery, Santa Rita Clinic, Vercelli, Italy.

Rectal prolapse, rectal procidentia, "complete" prolapse or "third-degree" prolapse is the full-thickness prolapse of the rectal wall through the anal canal and has a significant impact on quality of life. The incidence of rectal prolapse has been estimated to be approximately 2.5 per 100,000 inhabitants with a clear predominance among elderly women. Read More

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December 2018

Late systemic symptoms in head and neck cancer survivors.

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Department of Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232, USA.

Purpose: Neuroinflammation and central sensitization from cancer and its therapy may result in chronic systemic symptoms (CSS) such as fatigue, sleep disturbance, chronic widespread pain, mood disorders, neuropsychiatric symptoms, and temperature dysregulation. We undertook a cross-sectional study of CSS in head and neck cancer (HNC) survivors to determine their frequency, severity, and impact.

Methods: HNC patients without evidence of recurrence who were at least 12 months post-treatment completed a one-time battery of self-report measures including the Vanderbilt Head and Neck Symptom survey plus the General Symptom Subscale, the Body Image Quality of Life Inventory, Neurotoxicity Rating Scale, the Profile of Mood States, and a five-item quality of life measure. Read More

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December 2018

Prognostic models for predicting overall survival in metastatic castration-resistant prostate cancer: a systematic review.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

UroEvidence@Deutsche Gesellschaft für Urologie, Berlin, Germany.

Purpose: Prognostic models are developed to estimate the probability of the occurrence of future outcomes incorporating multiple variables. We aimed to identify and summarize existing multivariable prognostic models developed for predicting overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC).

Methods: The protocol was prospectively registered (CRD42017064448). Read More

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December 2018

Neurocognitive, academic and functional outcomes in survivors of infant ependymoma (UKCCSG CNS 9204).

Childs Nerv Syst 2018 Dec 15. Epub 2018 Dec 15.

Children's Brain Tumour Research Centre, Academic Division of Child Health, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2RD, UK.

Purpose: This is the first UK multi-centre case-controlled study with follow-up in excess of 10 years to report the neurocognitive, academic and psychological outcomes of individuals diagnosed with a brain tumour in early childhood. Children enrolled into the UKCCSG CNS 9204 trial, diagnosed with intracranial ependymoma when aged ≤ 36 months old, who received a primary chemotherapy strategy to defer or avoid radiotherapy, were recruited.

Methods: Outcomes of those who relapsed and subsequently received radiotherapy (n = 13) were compared to those enrolled who did not relapse (n = 16), age-matched controls-diagnosed with solid non-central nervous system (SN-CNS; n = 15) tumours or low-grade posterior fossa pilocytic astrocytoma (PFPA; n = 15), and normative data. Read More

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December 2018

Minimally Invasive Function-Preserving Gastrectomy with Sentinel Node Biopsy for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):14-20. Epub 2018 Dec 14.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: Recently, minimally invasive approaches such as endoscopic treatment or laparoscopic gastrectomy for early gastric cancer have made rapid progress. However, the extent of gastrectomy and lymphadenectomy in laparoscopic surgery is radical, similar to that of open gastrectomy for patients with early gastric cancer diagnosed as not indicated for endoscopic treatment. Since it is well known that lymph node metastasis is an important prognostic factor, the standard procedure of gastrectomy with radical lymph node dissection has been performed for the purpose of curative resection. Read More

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December 2018

Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial.

Digestion 2018 Dec 14:1-10. Epub 2018 Dec 14.

Department of Gastroenterology, Asahi General Hospital, Chiba, Japan.

Background/aims: Feeding recommendations after endoscopic submucosal dissection (ESD) for gastric neoplasms are not established and based on clinical experience.

Methods: This was a prospective pilot randomized controlled trial. Patients undergoing ESD for gastric neoplasms were randomly assigned to solid (n = 50) or liquid diet (n = 50) groups. Read More

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December 2018

The REACH Trial: A Randomized Controlled Trial Assessing the Safety and Effectiveness of the Spiration® Valve System in the Treatment of Severe Emphysema.

Respiration 2018 Dec 14:1-12. Epub 2018 Dec 14.

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou,

Background: Chronic obstructive pulmonary disease (COPD) has become a leading cause of morbidity and mortality in China, with tobacco smoke, air pollution, and occupational biohazards being the major risk factors.

Objectives: The REACH trial is a multicenter, prospective, randomized controlled trial undertaken in China to assess the safety and effectiveness of the Spiration® Valve System (SVS) compared to standard medical care in COPD patients with severe emphysema.

Methods: Patients with severe airflow obstruction, hyperinflation, and severe dyspnea with interlobar fissure integrity were evaluated for enrollment. Read More

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December 2018

Putrescine delays postovulatory aging of mouse oocytes by upregulating PDK4 expression and improving mitochondrial activity.

Aging (Albany NY) 2018 Dec 16. Epub 2018 Dec 16.

Reproductive Medicine Center, First Affiliated Hospital of Soochow University, Suzhou Jiangsu, China.

If fertilization does not occur for a prolonged period or , the postovulatory oocytes will deteriorate, which called the postovulatory aging. This process disrupts the developmental competence. In the present study, we showed that the reactive oxygen species (ROS) was accumulated in oocytes during the postovulatory aging. Read More

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December 2018

Contralateral acute vascular occlusion following revascularization surgery for moyamoya disease.

Authors:

J Neurosurg 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVERevascularization surgery is a safe and effective surgical treatment for symptomatic moyamoya disease (MMD) and has been shown to reduce the frequency of future ischemic events and improve quality of life in affected patients. The authors sought to investigate the occurrence of acute perioperative occlusion of the contralateral internal carotid artery (ICA) with contralateral stroke following revascularization surgery, a rare complication that has not been previously reported.METHODSThis study is a retrospective review of a prospective database of a single surgeon's series of revascularization operations in patients with MMD. Read More

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December 2018

Unintended consequences of the electronic medical record on physicians in training and their mentors.

Postgrad Med J 2018 Dec 15. Epub 2018 Dec 15.

Aurora Health Care - Green Bay, Hobart, Wisconsin, USA

For physicians in training and their mentors, the process of learning and teaching clinical medicine has become challenging in the electronic medical record (EMR) era. Trainees and their mentors exist in a milieu of incessant box checking and laborious documentation that has no clinical educational value, limits the time for teaching and curtails clinical cognitive skill development. These unintended consequences of the EMR are juxtaposed against the EMR's intended benefits of improved patient care and safety with reduced medical errors, improved clinical support systems, reduced potential for negligence with clinical data and metadata data supporting compliance with the standard of care. Read More

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December 2018

Use of supplemental oxygen in emergency patients: a systematic review and recommendations for military clinical practice.

J R Army Med Corps 2018 Dec 15. Epub 2018 Dec 15.

Emergency Department, University Hospitals Plymouth NHS Trust, Plymouth, UK.

Introduction: Supplemental oxygen is a key element of emergency treatment algorithms. However, in the operational environment, oxygen supply poses a challenge. The lack of high-quality evidence alongside emerging technologies provides the opportunity to challenge current guidelines. Read More

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December 2018

Rates and characteristics of postcolonoscopy colorectal cancer in the Swedish IBD population: what are the differences from a non-IBD population?

Gut 2018 Dec 15. Epub 2018 Dec 15.

Department of Medicine, Solna (MedS), Karolinska Institutet, Stockholm, Sweden.

Objective: The rate of postcolonoscopy colorectal cancer (PCCRC) is considered a key quality indicator of colonoscopy; little is known about PCCRC in IBD.

Design: A population-based cohort study of colonoscopies in Sweden from 2001 to 2010 was conducted. Individuals with a colorectal cancer (CRC) detected within 36 months after a colonoscopy were identified and stratified on UC, Crohn's disease (CD) or non-IBD. Read More

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December 2018

PsAID12 Provisionally Endorsed at OMERACT 2018 as Core Outcome Measure to Assess Psoriatic Arthritis-specific Health-related Quality of Life in Clinical Trials.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore; Department of Medicine, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Division of Immunology, Stanford University, Palo Alto, California; Rheumatology Research, Swedish Medical Center and University of Washington School of Medicine, Seattle, Washington; Global Patient Outcomes and Real World Evidence, Eli Lilly and Co., Indianapolis, Indiana; University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Utah, Salt Lake City, Utah, USA; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Royal National Hospital for Rheumatic Diseases, Bath; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Sorbonne Université; Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP, Paris, France; VU Medical Centre, Amsterdam, the Netherlands; Global Medical Affairs, Pfizer Inc., Montreal, Quebec; Clinical Epidemiology Program, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Musculoskeletal Health and Outcomes Research, St. Michael's Hospital and Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute, Institute for Health Policy Management and Evaluation, University of Toronto; University of Toronto; Krembil Research Institute; Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada; Department of Rheumatology, St. Vincent's University Hospital and Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland. AMO is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the US National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; R. Holland, MB, ChB, Royal Prince Alfred Hospital Medical Centre; Y.Y. Leung, MD, PhD, Department of Rheumatology and Immunology, Singapore General Hospital; W. Tillett, BSc, MBChB, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; N. Goel, MD, Patient Research Partner, Department of Medicine, Duke University School of Medicine, and Kezar Life Sciences; R. Christensen, BSc, MSc, PhD, Professor of Biostatistics and Clinical Epidemiology, and Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; N. McHugh, MBChB, MD, FRCP, FRCPath, Royal National Hospital for Rheumatic Diseases; L. Gossec, MD, PhD, Sorbonne Université, and Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP; M. de Wit, PhD, Patient Research Partner, VU Medical Centre; P. Højgaard, MD, The Parker Institute, Bispebjerg and Frederiksberg Hospital; L.C. Coates, MBChB, PhD, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; P.J. Mease, MD, Rheumatology Research, Swedish Medical Center and University of Washington School of Medicine; J. Birt, PharmD, Global Patient Outcomes and Real World Evidence, and Eli Lilly and Co.; L. Fallon, PhD, Global Medical Affairs, Pfizer Inc.; O. FitzGerald, MD, FRCPI, FRCP(UK), Newman Clinical Research Professor, Department of Rheumatology, St. Vincent's University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; A. Ogdie, MD, MSCE, University of Pennsylvania; B. Shea, PhD, Clinical Epidemiology Program, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; V. Strand, MD, Division of Immunology, Stanford University; K. Callis Duffin, MD, Department of Dermatology, University of Utah; P. Tugwell, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D. Beaton, BScOT, PhD, Musculoskeletal Health and Outcomes Research, St. Michael's Hospital and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute, and the Institute for Health Policy Management and Evaluation, University of Toronto; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, and Senior Scientist, Krembil Research Institute, and Director, Psoriatic Arthritis Program, University Health Network. Address correspondence to Dr. A.M. Orbai, MD, MHS, Assistant Professor of Medicine, Rheumatology, Director Psoriatic Arthritis Program, Johns Hopkins University School of Medicine, Division of Rheumatology, 5200 Eastern Ave., MFL Center Tower Suite 4100, Baltimore, Maryland 21224, USA. E-mail: Accepted for publication November 6, 2018.

Objective: The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) psoriatic arthritis (PsA) working group is developing a Core Outcome Measurement Set for PsA clinical trials [randomized controlled trials (RCT) and longitudinal observational studies (LOS)] using the OMERACT Filter 2.1 instrument selection algorithm. Our objective was to assess the Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) for the measurement of the core domain PsA-specific health-related quality of life (HRQOL). Read More

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December 2018
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Health-related quality of life in surgical children and adolescents with congenital heart disease compared with their age-matched healthy sibling: a cross-sectional study from a lower middle-income country, Pakistan.

Arch Dis Child 2018 Dec 15. Epub 2018 Dec 15.

Charles Perkins Centre and Susan Wakil School of Nursing and Midwifery, Sydney Nursing School, University of Sydney, Camperdown, New South Wales, Australia.

Objective: Inconsistencies have been reported in health-related quality of life (HRQOL) in postoperative congenital heart disease (CHD). Despite the need for lifelong care due for residual symptoms, only a few studies have explored cardiac-related HRQOL but none in lower middle-income countries (LMIC). This study therefore addresses the gap by exploring HRQOL and its associated predictors in postoperative CHD in Pakistan. Read More

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December 2018

SMART-CPT for veterans with comorbid post-traumatic stress disorder and history of traumatic brain injury: a randomised controlled trial.

J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.

Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA.

Objective: To better concurrently address emotional and neuropsychological symptoms common in veterans with comorbid post-traumatic stress disorder (PTSD) and history of traumatic brain injury (TBI), we integrated components of compensatory cognitive training from the Cognitive Symptom Management and Rehabilitation Therapy (CogSMART) programme into cognitive processing therapy (CPT) for PTSD to create a hybrid treatment, SMART-CPT (CogSMART+CPT). This study compared the efficacy of standard CPT with SMART-CPT for treatment of veterans with comorbid PTSD and history of TBI reporting cognitive symptoms.

Methods: One hundred veterans with PTSD, a history of mild to moderate TBI and current cognitive complaints were randomised and received individually delivered CPT or SMART-CPT for 12 weeks. Read More

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December 2018

Public stigma of obsessive compulsive disorder and schizophrenic disorder: Is there really any difference?

Psychiatry Res 2018 Dec 10;271:559-564. Epub 2018 Dec 10.

Department of Psychology, Faculty of Arts, Dokuz Eylül University, Buca, İzmir, Turkey.

A substantial delay for help-seeking is a serious problem for people with obsessive-compulsive disorder (OCD), a heterogeneous and debilitating mental health condition. Stigma is a major barrier to treatment seeking and further cause social and occupational impairment. Lack of comprehensive research led us to examine the public's stigmatizing attitudes towards checking, contamination, sexuality, aggression, and religion-related OCD symptoms, compared to schizophrenia. Read More

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December 2018

Meaning in life buffers the association between clinical anxiety and global maladjustment in participants with common mental disorders on sick leave.

Psychiatry Res 2018 Dec 6;271:548-553. Epub 2018 Dec 6.

Escuela de doctorado. Universidad Católica de Valencia, San Vicente Mártir, España; Catedra UMIVALE Innovación e investigación en patologías del trabajo, Valencia, España.

An important goal of mental health specialists is to improve the quality of life and the adaptation of people with common mental disorders on sick leave. Meaning in life is a protective factor for people adjusting to distress and negative events. This study explores the buffering role of meaning in life in the relationship between clinical anxiety or negative affect and maladjustment in participants with common mental disorders on sick leave. Read More

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December 2018

Adsorptive removal of patulin from apple juice via sulfhydryl-terminated magnetic bead-based separation.

J Hazard Mater 2018 Dec 3;366:413-422. Epub 2018 Dec 3.

Department of Bioengineering, Karamanoğlu Mehmetbey University, Karaman, Turkey.

Patulin is a naturally produced toxin having potential carcinogenic properties. It is mainly produced by species of Penicillium growing on fruits, especially on apples. Detoxification of patulin, therefore, is very important for providing food safety. Read More

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December 2018
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Gender-specific prevalence of poor sleep quality and related factors in a Chinese rural population: the Henan Rural Cohort Study.

Sleep Med 2018 Nov 22;54:134-141. Epub 2018 Nov 22.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Objective: To estimate the prevalence of poor sleep quality and identify related factors by gender in the Chinese rural population.

Methods: Overall, 27424 subjects (10881 males and 16543 females) aged 18-79 years were enrolled from the Henan Rural Cohort Study. Sleep quality was evaluated by the standard Pittsburgh Sleep Quality Index (PSQI) and global score>5 was classified as poor sleep quality. Read More

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November 2018

Pre-awake light exposure and sleep disturbances: findings from the HEIJO-KYO cohort.

Sleep Med 2018 Nov 14;54:121-125. Epub 2018 Nov 14.

Department of Epidemiology, Nara Medical University School of Medicine, Nara, Japan.

Objectives: To evaluate the associations between pre-awake light (PAL) exposure and subjective and objective measures of sleep quality.

Methods: In this cross-sectional study of 1108 elderly participants (mean age, 71.9 years), we measured bedroom light intensity using a bedside light meter for two nights and sleep quality using actigraphy and a questionnaire. Read More

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November 2018

Distribution of antibiotic resistance genes in soils and crops. A field study in legume plants (Vicia faba L.) grown under different watering regimes.

Environ Res 2018 Dec 6;170:16-25. Epub 2018 Dec 6.

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, 08034 Barcelona, Spain. Electronic address:

Social concern has raised during the last years due to the development of antibiotic resistance hotspots in different environmental compartments, including the edible parts of crops. To assess the influence of the water quality used for watering, we collected samples from soil, roots, leaves and beans from the legume plant Vicia faba (broad beans) in three agricultural peri-urban plots (Barcelona, NE Spain), irrigated with either groundwater, river water, or reclaimed water. Antibiotic resistance genes (ARGs) sul1, tetM, qnrS1, blabla, mecA, and bla were quantified by real-time PCR, along with 16S rDNA and intl1 sequences, as proxies for bacterial abundance and integron prevalence, respectively. Read More

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December 2018

Engineered nanomaterials inhibit Podosphaera pannosa infection on rose leaves by regulating phytohormones.

Environ Res 2018 Dec 6;170:1-6. Epub 2018 Dec 6.

Stockbridge School of Agriculture, University of Massachusetts Amherst, Amherst, MA 01003, United States.

In the present study, we investigated the antifungal effects of engineered nanomaterials (ENMs) against Podosphaera pannosa (P. pannosa), a fungal pathogen that causes powdery mildew on plants in the rose family. Four commercial ENMs, including multi-wall carbon nanotubes (MWCNTs), reduced graphene oxide (rGO), copper oxide (CuO) nanoparticles (NPs) and titanium dioxide (TiO) NPs, were used to prepare 50 or 200 mg/L NP suspensions in deionized water. Read More

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December 2018

Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.

Mult Scler Relat Disord 2018 Dec 9;28:64-68. Epub 2018 Dec 9.

Johns Hopkins University, School of Medicine, Department of Neurology, Baltimore, MD, USA.

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that preferentially targets the spinal cord and optic nerves. Increasing disability is accrued with each inflammatory attack. Disability has been shown to be an independent predictor of poor quality of life in those with NMOSD. Read More

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December 2018

Evaluation of emotional skills in nursing using regression and QCA models: A transversal study.

Nurse Educ Today 2018 Dec 7;74:31-37. Epub 2018 Dec 7.

Department of Social Psychology, University of Valencia, Valencia, Spain. Electronic address:

Background: Emotional skills are fundamental for quality service by nursing professionals, providing more personalized attention and a close relationship between the professional and patient.

Objectives: To compare linear relationship models (linear regressions) and models based on comparative qualitative analysis (QCA) in the analysis of the possible influence of socio-demographic variables (age and sex), working conditions (type of contract and seniority) and academic training (type of degree and specific training) on emotional abilities (emotional intelligence and empathy) in nursing.

Design: It is a transversal design in a single temporary moment. Read More

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December 2018

Best practices for teaching pharmacology to undergraduate nursing students: A systematic review of the literature.

Nurse Educ Today 2018 Dec 7;74:15-24. Epub 2018 Dec 7.

Faculty of Health and Social Development, School of Nursing, University of British Columbia, Kelowna, BC, Canada.

Objective: In this systematic review we describe best practices for teaching pharmacology to undergraduate baccalaureate nursing students based on the available evidence. Numerous teaching strategies employed in undergraduate pharmacology courses for nursing students have been summarized and compared for their impact on pharmacology knowledge retention, application of pharmacology theory to practice, and student satisfaction. Future directions for research are discussed. Read More

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December 2018

Phospholipase A2 products predict the hematopoietic support capacity of horse serum.

Differentiation 2018 Dec 6;105:27-32. Epub 2018 Dec 6.

Department of Hematology and Oncology, Medical Faculty, University of Leipzig, Leipzig, Germany.

Horse serum is commonly used as an additive to support the maintenance of hematopoietic progenitor cells in culture. However, the wide variability in the performance of different lots calls for parallel testing of multiple batches over extended periods of culture. Identification of the serum components that determine hematopoietic support would therefore save considerable time and effort and would help to standardize culture procedures. Read More

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December 2018

Pathological laughter as an early and unusual presenting symptom of petroclival meningioma: A case report and review of literature.

World Neurosurg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, India.

Background: Pathological laughter is inappropriate, involuntary and unmotivated laughter episodes which may or may not be associated with mirth or amusement. Though associated with many diffuse brain pathologies, its association with intracranial focal mass lesions causing ventrolateral brainstem compression like petroclival meningioma is very rare. The exact pathophysiology of this interesting and unusual clinical symptom is unknown but probably involves disinhibition and release of the so-called coordination center located in the upper brainstem due to compression by the tumor. Read More

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December 2018

Predictive validity of hypodensities on non-contrast computed tomography for hematoma growth in intracerebral hemorrhage: a meta-analysis.

World Neurosurg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address:

Objective: Intracerebral hemorrhage (ICH) is a kind of stroke which leads to high mortality. Hematoma growth (HG) happens in about one third of all ICH patients and independently related to poor outcome. Previous studies have shown that an indicator on non-contrast computed tomography (NCCT), called hypodensities, can predict HG in ICH patients. Read More

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December 2018

μImpact of a nursing-driven sedation protocol with criteria for infusion initiation in the surgical intensive care unit.

J Crit Care 2018 Nov 30;50:195-200. Epub 2018 Nov 30.

Department of Pharmacy, The Ohio State University Wexner Medical Center, 410 W. 10th Avenue, Columbus, OH 43210, USA. Electronic address:

Purpose: Analgesia and sedation protocols (ASPs) reduce duration of mechanical ventilation (MV) in the medical intensive care unit (ICU), but data in the surgical ICU (SICU) are limited. The objective of this study was to determine the impact of a nursing-driven ASP with criteria for infusion initiation in the SICU.

Materials And Methods: A single-center, retrospective study compared ventilator-free days at day 28 from start of MV (VFD28) before and after ASP implementation. Read More

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November 2018

The change in microstructure of petioles and peduncles and transporter gene expression by potassium influences the distribution of nutrients and sugars in pear leaves and fruit.

J Plant Physiol 2018 Nov 29;232:320-333. Epub 2018 Nov 29.

Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, National Engineering Research Center for Organic-based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:

Potassium (K) is one of the most important mineral nutrients required for fruit growth and development and is known as a 'quality element'. To investigate the role of K in more detail, we performed experiments in which seven-year-old pot-grown 'Huangguan' pear trees were treated with three levels of K (0, 0.4, or 0. Read More

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November 2018

Functional outcomes and health-related quality of life following curative treatment for rectal cancer: A population-level study in England.

Int J Radiat Oncol Biol Phys 2018 Dec 13. Epub 2018 Dec 13.

Leeds Institute of Cancer & Pathology, University of Leeds, Leeds LS2 9LN.

Background: There is a growing population of cancer survivors at risk of treatment-related morbidity. This study investigates how potentially curative rectal cancer treatment influences subsequent function and health-related quality of life (HRQL) using data from a large-scale survey of patient-reported outcomes.

Methods: All individuals 12-36 months post-diagnosis of colorectal cancer in England were sent a survey in January 2013. Read More

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December 2018

Iron Deficiency in Heart Failure: An Overview.

JACC Heart Fail 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology and Metabolism-Heart Failure, Cachexia and Sarcopenia, Department of Cardiology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Iron deficiency is an extremely common co-morbidity in patients with heart failure, affecting up to 50% of all ambulatory patients. It is associated with reduced exercise capacity and physical well-being and reduced quality of life. Cutoff values have been identified for diagnosing iron deficiency in heart failure with reduced ejection fraction as serum ferritin, <100 μg/l, or ferritin, 100 to 300 μg/l, with transferrin saturation of <20%. Read More

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December 2018

Use of probiotics in aquaculture of China-a review of the past decade.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Sino-Norway Fish Gastrointestinal Microbiota Joint Lab, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, PR China. Electronic address:

China is the largest aquaculture producer in the world. Antibiotics were extensively used to ensure the development of the intensive aquaculture; however, the use of antibiotics causes safety- and environment-associated problems. As an alternative strategy to antibiotics, aquatic probiotics have attracted attention. Read More

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December 2018

Home food availability and child intake among rural families identified to be at-risk for health disparities.

Appetite 2018 Dec 13. Epub 2018 Dec 13.

Food Science & Human Nutrition, Colorado State University, United States. Electronic address:

Background: Home food environments (HFE) of children impact dietary intake, though relatively few studies have focused on young children from backgrounds with socioeconomic and racial-ethnic diversity. The objective of the present study was to examine the relationship between the HFE and child dietary intake of preschool-aged children from rural and low-income, culturally diverse families.

Methods: Children (aged 2-5 years) and their primary caregivers (n = 164 parent-child dyads) participated in this study using a cross-sectional design. Read More

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December 2018

Imprinted genes influencing the quality of maternal care.

Front Neuroendocrinol 2018 Dec 13. Epub 2018 Dec 13.

Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, UK, CF10 3AX, UK. Electronic address:

In mammals successful rearing imposes a cost on later reproductive fitness specifically on the mother creating the potential for parental conflict. Loss of function of three imprinted genes in the dam result in deficits in maternal care suggesting that, like maternal nutrients, maternal care is a resource over which the parental genomes are in conflict. However, the induction of maternal care is a complex and highly regulated process. Read More

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December 2018

Is your assay stable? Using process stability and capability to evaluate assay performance.

Clin Chim Acta 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT, United States. Electronic address:

Background: Many laboratories are involved in efforts to increase precision and improve process capability. Metrics to evaluate performance, assess potential for improvement, and prioritize improvement projects would facilitate these efforts. We show how stability analysis can provide metrics to evaluate assay performance and indicate potential for improvement. Read More

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December 2018
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