6,066 results match your criteria Q Fever


A case report of ulceroglandular tularemia caused by Francisella tularensis subsp. holarctica in Iran.

Acta Trop 2022 Jun 22:106570. Epub 2022 Jun 22.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: Tularemia is a zoonotic disease that has been reported in many countries of the Northern Hemisphere. However, in some countries, such as Iran, this disease has been neglected by the health care system, and it is under-reported.

Case Presentation: Here we report an unusual case of ulceroglandular tularemia occurring in a 35-year-old woman who presented with a skin lesion of the left flank, inguinal lymphadenopathy, and an abdominal abscess. Read More

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Sero-Epidemiology of Infection in Small Ruminants in the Eastern Region of Punjab, Pakistan.

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, 07743 Jena, Germany.

The aim of this study was to investigate the seroprevalence of Q fever in sheep and goats in Kasur, Okara, and Pakpattan in the Punjab of Pakistan. Q fever is a widely reported zoonotic disease caused by (.) . Read More

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Targeted Screening for Chronic Q Fever, the Netherlands.

Emerg Infect Dis 2022 Jul;28(7):1403-1409

Early detection of and treatment for chronic Q fever might prevent potentially life-threatening complications. We performed a chronic Q fever screening program in general practitioner practices in the Netherlands 10 years after a large Q fever outbreak. Thirteen general practitioner practices located in outbreak areas selected 3,419 patients who had specific underlying medical conditions, of whom 1,642 (48%) participated. Read More

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Incidence and severity of SARS-CoV-2 infection in former Q fever patients as compared to the Dutch population, 2020-2021.

Epidemiol Infect 2022 Jun 8;150:e116. Epub 2022 Jun 8.

Centre for Infectious Diseases, Epidemiology and Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Surveillance data shows a geographical overlap between the early coronavirus disease 2019 (COVID-19) pandemic and the past Q fever epidemic (2007-2010) in the Netherlands. We investigated the relationship between past Q fever and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 2020/2021, using a retrospective matched cohort study.In January 2021, former Q fever patients received a questionnaire on demographics, SARS-CoV-2 test results and related hospital/intensive care unit (ICU) admissions. Read More

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Fluorescence in situ hybridization for detecting Coxiella burnetii in tissue samples from chronic Q fever patients.

Clin Microbiol Infect 2022 Jun 17. Epub 2022 Jun 17.

Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.

Objective: Detection of the intracellular bacterium Coxiella burnetii, causative agent of chronic Q fever, is notoriously difficult. Diagnosis of and duration of antibiotic treatment for chronic Q fever is partly determined by detection of the bacterium with polymerase chain reaction (PCR). Fluorescence in situ hybridization (FISH) might be a promising technique for detecting C. Read More

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Acute multifocal retinitis in a patient with Q fever (Coxiella Burnetii infection) with endocarditis.

J Ophthalmic Inflamm Infect 2022 Jun 20;12(1):19. Epub 2022 Jun 20.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

Objective: To report acute multifocal retinitis in association with serologically-proven Coxiella (C) Burnetii infection (Q fever) with endocarditis.

Material And Methods: A single case report documented with multimodal imaging.

Results: A 67-year-old cattle breeder presented with a 2-week history of persistent fever, headache, and floaters in both eyes. Read More

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Case Report: Metagenomic Next-Generation Sequencing Clinches the Diagnosis of Acute Q Fever and Verified by Indirect Immunofluorescence Assay.

Front Med (Lausanne) 2022 26;9:846526. Epub 2022 May 26.

Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China.

Q fever is a zoonotic infectious disease caused by . The clinical symptoms of acute Q fever are usually atypical, and routine serological tests of are not readily available, making the diagnosis of Q fever a challenge. In this case, we report a male patient who had repeated fevers and was administered empirical anti-infective treatment, but the effect was poor. Read More

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High incidence of acute Q fever among incarcerated people in Cayenne, French Guiana.

Rev Inst Med Trop Sao Paulo 2022 10;64:e42. Epub 2022 Jun 10.

Centre Hospitalier de Cayenne, Cayenne, French Guiana, France.

Q fever is a major public health problem in French Guiana. In recent years, a considerable number of cases has been reported in French Guiana's penitentiary center. The main objective of this study was to describe the epidemiology of these cases. Read More

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Immunogenicity and Reactogenicity in Q Fever Vaccine Development.

Front Immunol 2022 26;13:886810. Epub 2022 May 26.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United States.

is an obligate intracellular bacterium which, in humans, causes the disease Q fever. Although Q fever is most often a mild, self-limiting respiratory disease, it can cause a range of severe syndromes including hepatitis, myocarditis, spontaneous abortion, chronic valvular endocarditis, and Q fever fatigue syndrome. This agent is endemic worldwide, except for New Zealand and Antarctica, transmitted aerosols, persists in the environment for long periods, and is maintained through persistent infections in domestic livestock. Read More

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Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing.

Front Med (Lausanne) 2022 18;9:855020. Epub 2022 May 18.

Department of Neurology, the Second Xiangya Hospital, Central South University, Changsha, China.

Query fever (Q fever) is a widespread zoonotic disease caused by the bacterium of (). Its neurological complications are rarely reported. But they may lead to severe consequences. Read More

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Validation of an Indirect Immunofluorescence Assay and Commercial Q Fever Enzyme-Linked Immunosorbent Assay for Use in Macropods.

J Clin Microbiol 2022 Jun 2:e0023622. Epub 2022 Jun 2.

Asia Pacific Centre for Animal Health, Melbourne Veterinary School, The University of Melbournegrid.1008.9, Parkville, Victoria, Australia.

Kangaroos are considered to be an important reservoir of Q fever in Australia, although there is limited knowledge on the true prevalence and distribution of coxiellosis in Australian macropod populations. Serological tests serve as useful surveillance tools, but formal test validation is needed to be able to estimate true seroprevalence rates, and few tests have been validated to screen wildlife species for Q fever. In this study, we modified and optimized a phase-specific indirect immunofluorescence assay (IFA) for the detection of IgG antibodies against Coxiella burnetii in macropod sera. Read More

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Evaluation of a Human T Cell-Targeted Multi-Epitope Vaccine for Q Fever in Animal Models of Immunity.

Front Immunol 2022 16;13:901372. Epub 2022 May 16.

Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA, United States.

T cell-mediated immunity plays a central role in the control and clearance of intracellular infection, which can cause Q fever. Therefore, we aimed to develop a novel T cell-targeted vaccine that induces pathogen-specific cell-mediated immunity to protect against Q fever in humans while avoiding the reactogenicity of the current inactivated whole cell vaccine. Human HLA class II T cell epitopes from were previously identified and selected by immunoinformatic predictions of HLA binding, conservation in multiple isolates, and low potential for cross-reactivity with the human proteome or microbiome. Read More

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Novel genotypes of Coxiella burnetii circulating in rats in Yunnan Province, China.

BMC Vet Res 2022 May 27;18(1):204. Epub 2022 May 27.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.

Background: Coxiella burnetii (Cb) is the causative agent of the zoonotic disease Q fever which is distributed worldwide. Molecular typing of Cb strains is essential to find out the infectious source and prevent Q fever outbreaks, but there has been a lack of typing data for Cb strains in China. The aim of this study was to investigate the genotypes of Cb strains in wild rats in Yunnan Province, China. Read More

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Abattoir-Based Serological Surveillance and Spatial Risk Analysis of Foot-and-Mouth Disease, Brucellosis, and Q Fever in Lao PDR Large Ruminants.

Trop Med Infect Dis 2022 May 18;7(5). Epub 2022 May 18.

Maihdol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

A national animal disease surveillance network initiated by the Lao PDR government is adopted and reinforced by a joint research project between the National Animal Health Laboratory (NAHL), the Department of Livestock and Fisheries (DLF), and the Mahidol Oxford Tropical Medicine Research Unit (MORU). The network is strengthened by staff training and practical exercises and is utilised to provide zoonotic or high-impact disease information on a national scale. Between January and December 2020, large ruminant samples are collected monthly from 18 abattoirs, one in each province, by provincial and district agriculture and forestry officers. Read More

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A Case Report of Infective Endocarditis with Failure of the Empirical Treatment-Q Fever Endocarditis Diagnosed by Metagenomic Next-Generation Sequencing.

Infect Drug Resist 2022 18;15:2545-2550. Epub 2022 May 18.

Department of Infectious Disease, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, People's Republic of China.

Background: Infective endocarditis (IE) can be caused by a variety of pathogens. Endocarditis due to the () infection is common in patients with negative blood culture results and usually occurs in patients with previous valvular heart disease, impaired immune function, and during pregnancy. The diagnosis is difficult based on the conventional diagnostic method, and serious adverse outcomes may occur in the case of delayed diagnosis. Read More

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Characterization of recombinant Ybgf protein for the detection of antibodies in ruminants.

J Vet Diagn Invest 2022 May 24:10406387221093581. Epub 2022 May 24.

Department of Veterinary Medicine and Animal Productions, University of Naples, "Federico II", Naples, Italy.

Q fever remains a One Health problem, posing a zoonotic threat and causing significant economic losses to the livestock industry. The advancement of detection tools is critical to the effective control of infection. In humans, laboratory investigations depend largely on the immunofluorescence assay, considered the gold standard. Read More

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Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin-rifampin treatment and complex reconstruction were needed for the cure.

Arthroplasty 2021 Dec 2;3(1):43. Epub 2021 Dec 2.

Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103 Grande-Rue de la Croix-Rousse, 69004, Lyon, France.

Background: Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii, a strictly intracellular pathogen that can cause acute and chronic infection. Chronic Q fever can occur in immunocompetent as well as in immuno-compromised hosts, as a persistent localized infection. The main localizations are endocardial, vascular and, less frequently, osteoarticular. Read More

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December 2021

The First Case of Coxiella Burnetti Infection Detected Through Bone Marrow Biopsy in Vietnam.

Clin Pathol 2022 Jan-Dec;15:2632010X221096397. Epub 2022 May 12.

The Center of Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi, Vietnam.

is an obligate intracellular bacterium that causes the zoonotic infectious disease, Q fever. The common clinical presentation is fever, hepatitis, and pneumonia; laboratory examination could reveal pancytopenia, elevated liver enzymes. In bone marrow, many fibrin ring granulomas, also known as "Doughnut" granulomas can be seen and suggest the diagnosis of Q fever. Read More

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Coxiella burnetii Plasmid Effector B Promotes LC3-II Accumulation and Contributes To Bacterial Virulence in a SCID Mouse Model.

Infect Immun 2022 Jun 19;90(6):e0001622. Epub 2022 May 19.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Fengtai, Beijing, People's Republic of China.

Coxiella burnetii, the causative agent of zoonotic Q fever, is characterized by replicating inside the lysosome-derived -containing vacuole (CCV) in host cells. Some effector proteins secreted by C. burnetii have been reported to be involved in the manipulation of autophagy to facilitate the development of CCVs and bacterial replication. Read More

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High endemicity of Q fever in French Guiana: A cross sectional study (2007-2017).

PLoS Negl Trop Dis 2022 05 18;16(5):e0010349. Epub 2022 May 18.

Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne Andrée Rosemon, Cayenne, French Guiana.

Q fever (QF) is a zoonosis caused by Coxiella burnetii (Cb). French Guiana (FG) had a high incidence but no data have been published since 2006. The objective of this study was to update the incidence and epidemiological data on QF in FG. Read More

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A cross-sectional survey of risk factors for the presence of Coxiella burnetii in Australian commercial dairy goat farms.

Aust Vet J 2022 May 18. Epub 2022 May 18.

Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.

The largest Australian farm-based outbreak of Q fever originated from a dairy goat herd. We surveyed commercial dairy goat farms across Australia by testing bulk tank milk (BTM) samples using a commercial indirect enzyme-linked immunosorbent assay and two quantitative polymerase chain reactions (PCRs). Of the 66 commercial dairy goat herds on record, managers from 61 herds were contacted and 49 provided BTM samples. Read More

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Culture-negative polymicrobial chronic Q fever prosthetic valve infective endocarditis utilizing 16S ribosomal RNA polymerase chain reaction on explanted valvular tissue.

Int J Infect Dis 2022 Aug 11;121:138-140. Epub 2022 May 11.

St George Hospital, Sydney, New South Wales, Australia; School of Clinical Medicine, St George & Sutherland Campus, UNSW Medicine & Health; Menzies School of Health Research, Charles Darwin University.

Coxiella burnetti is the causative organism of the zoonotic infection Q fever, of which endocarditis is one of the most common manifestations of the chronic form. Polymicrobial endocarditis with Q fever is extremely rare and is yet to be described among an Australasian cohort. SUMMARY: We present the case of a 32-year-old gardener with culture-negative chronic Q fever prosthetic valve endocarditis concomitant with another bacterial pathogen, leading to aortic root abscess formation, requiring a Bentall procedure, extracorporeal membrane oxygenation, and prolonged antimicrobial therapy, with a fatal outcome. Read More

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Seropositivity for Coxiella burnetii in suspected patients with dengue in São Paulo state, Brazil.

PLoS Negl Trop Dis 2022 05 10;16(5):e0010392. Epub 2022 May 10.

Department of Veterinary Hygiene and Public Health, Paulista State University "Júlio de Mesquita Filho", Botucatu, São Paulo, Brazil.

Q fever and brucellosis are zoonoses that cause fever and other systemic clinical signs in humans; their occurrences are neglected and the differential diagnosis for some diseases is disregarded. This study aimed to investigate the seropositivity for Coxiella burnetii and Brucella spp. antibodies in patients suspected of dengue from 38 municipalities in the state of São Paulo, Brazil. Read More

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Q-uestioning the Diagnosis: An Educational Case Report.

Can J Kidney Health Dis 2022 2;9:20543581221097749. Epub 2022 May 2.

Division of Nephrology, Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Rationale: Q fever is a zoonotic infection that may lead to acute or long-term renal injury. Given its rare incidence, Q fever is not often considered on the initial differential diagnosis for glomerular disease which can lead to delays in treatment. This case highlights the importance of avoiding early diagnostic closure and revisiting the differential diagnosis in the setting of an atypical clinical presentation or response to treatment. Read More

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Evaluation of the sensitivity and specificity of three diagnostic tests for Coxiella burnetii infection in cattle and buffaloes in Punjab (India) using Bayesian latent class analysis.

PLoS One 2022 5;17(5):e0254303. Epub 2022 May 5.

Faculty of Public and One Health, School of Health Sciences, University of Thessaly, Karditsa, Greece.

Q Fever is a zoonotic disease of significant animal and public health concern, caused by Coxiella burnetii (C. burnetii), an obligate intracellular bacterium. This study was done to evaluate the diagnostic sensitivity (DSe) and diagnostic specificity (DSp) of three diagnostic methods to diagnose C. Read More

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Exposure to multiple pathogens - serological evidence for Rift Valley fever virus, Coxiella burnetii, Bluetongue virus and Brucella spp. in cattle, sheep and goat in Mali.

PLoS Negl Trop Dis 2022 04 29;16(4):e0010342. Epub 2022 Apr 29.

International Livestock Research Institute, Dakar, Senegal.

An important problem for livestock production in Mali is occurrence of several infectious diseases. A particular challenge for control of pathogens that affect different species, especially in a system with mixed herds with cattle, sheep and goats. Therefore, this study aimed to investigate co-exposure with Rift Valley fever virus (RVFV), Coxiella burnetii, Bluetongue virus (BTV) and Brucella spp. Read More

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Serological Prevalence of and Risk Factors for Infection in Women of Punjab Province, Pakistan.

Int J Environ Res Public Health 2022 04 11;19(8). Epub 2022 Apr 11.

Friedrich-Loeffler-Institute, Institute of Bacterial Infections and Zoonoses, Naumburger Str. 96a, 07743 Jena, Germany.

Background: , the etiological agent of Q (query) fever, provokes abortions in ruminants and is suspected to cause adverse pregnancy outcomes in women. Infection of pregnant women is linked with high mortality and morbidity of the fetus and the mother is at high risk to acquire chronic Q fever. This research was conducted to evaluate the prevalence of Q fever in women and to detect associated risk factors in four districts of Punjab Province, Pakistan. Read More

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Viral and Bacterial Zoonotic Agents in Dromedary Camels from Southern Tunisia: A Seroprevalence Study.

Microorganisms 2022 Mar 29;10(4). Epub 2022 Mar 29.

Bundeswehr Institute of Microbiology (IMB), 80937 Munich, Germany.

The rapid spread of SARS-CoV-2 clearly demonstrated the potential of zoonotic diseases to cause severe harm to public health. Having limited access to medical care combined with severe underreporting and a lack of active surveillance, Africa carries a high burden of neglected zoonotic diseases. Therefore, the epidemiological monitoring of pathogen circulation is essential. Read More

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Diagnosis of Cattle Abortion: A One-Year Observational Study.

Pathogens 2022 Apr 1;11(4). Epub 2022 Apr 1.

Fundamental and Applied Research for Animal and Health (FARAH) Center, University of Liège, B-4000 Liege, Belgium.

Q fever is a zoonosis occurring worldwide in livestock. Often neglected in differential diagnoses, Q fever can persist in herds causing financial losses. In ruminants, well-known manifestations of Q fever are metritis, infertility, abortion, stillbirth and delivery of a weak or premature calf. Read More

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The Collateral Effect of COVID-19 on the Epidemiology of Airborne/Droplet-Transmitted Notifiable Infectious Diseases in Taiwan.

Antibiotics (Basel) 2022 Apr 3;11(4). Epub 2022 Apr 3.

Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan.

This study was conducted to compare the number of cases of airborne/droplet-transmitted notifiable infectious disease (NID) between the pandemic period (defined as from January 2020 to December 2021) and the pre-pandemic period (defined as the period from January 2018 to December 2019). The annual case numbers of airborne/droplet-transmitted NIDs from 2018 to 2021 were collected for comparison. Fourteen airborne/droplet-transmitted NIDs including measles, rubella, pertussis, influenza with severe complications, invasive pneumococcal diseases (IPD), Q fever, mumps, meningococcal meningitis, varicella, legionellosis, invasive Haemophilus influenzae type b infection, hantavirus syndrome, TB, and multidrug-resistant TB (MDRTB), were included for the analysis. Read More

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