5,868 results match your criteria Q Fever

Serological survey of Coxiella burnetii infections in dairy cattle, sheep, goats and zoo animals in Hungary - Short communication.

Acta Vet Hung 2021 Jun 8. Epub 2021 Jun 8.

3Institute for Veterinary Medical Research, Centre for Agricultural Research, Budapest, Hungary.

Q fever is a disease of high zoonotic potential, but interest in its causative agent is rather low although it causes some public health problems in Hungary. The prevalence of Q fever is highly variable by country. The main reservoirs of the disease are the same domestic ruminant species everywhere, but the epidemiological profile depends on the features of the specific reservoir. Read More

View Article and Full-Text PDF

Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions.

Curr Trop Med Rep 2021 Jun 1:1-10. Epub 2021 Jun 1.

Departamento de Tuberculosis, Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.

Purpose Of Review: In this review, we report on the state of knowledge about human Q fever in Brazil and on the Guiana Shield, an Amazonian region located in northeastern South America. There is a contrast between French Guiana, where the incidence of this disease is the highest in the world, and other countries where this disease is practically non-existent.

Recent Findings: Recent findings are essentially in French Guiana where a unique strain MST17 has been identified; it is probably more virulent than those usually found with a particularly marked pulmonary tropism, a mysterious animal reservoir, a geographical distribution that raises questions. Read More

View Article and Full-Text PDF

Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species.

BMC Bioinformatics 2021 Jun 2;22(1):296. Epub 2021 Jun 2.

USDA-ARS Animal Disease Research Unit, Pullman, WA, 99164, USA.

Background: Coxiella burnetii is the Gram-negative bacterium responsible for Q fever in humans and coxiellosis in domesticated agricultural animals. Previous vaccination efforts with whole cell inactivated bacteria or surface isolated proteins confer protection but can produce a reactogenic immune responses. Thereby a protective vaccine that does not cause aberrant immune reactions is required. Read More

View Article and Full-Text PDF

Epidemiological investigation and physician awareness regarding the diagnosis and management of Q fever in South Korea, 2011 to 2017.

PLoS Negl Trop Dis 2021 Jun 2;15(6):e0009467. Epub 2021 Jun 2.

Department of Infectious Diseases, Ajou University School of Medicine, Suwon, Republic of Korea.

Background: In South Korea, the number of Q fever cases has rapidly increased since 2015. Therefore, this study aimed to characterize the epidemiological and clinical features of Q fever in South Korea between 2011 and 2017.

Methods/principal Findings: We analyzed the epidemiological investigations and reviewed the medical records from all hospitals that had reported at least one case of Q fever from 2011 to 2017. Read More

View Article and Full-Text PDF

Rodent-Related Zoonotic Pathogens at the Human-Animal-Environment Interface in Qatar: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

School of Life Sciences, College of Agriculture, Engineering & Science, University of KwaZulu Natal, Durban 4000, South Africa.

Rodents are one of the most diversified terrestrial mammals, and they perform several beneficial activities in nature. These animals are also important as carriers of many pathogens with public health importance. The current systematic review was conducted to formulate a true depiction of rodent-related zoonoses in Qatar. Read More

View Article and Full-Text PDF

Geographical Variation in Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk.

Pathogens 2021 May 23;10(6). Epub 2021 May 23.

UQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia.

Q fever is a zoonotic disease that is caused by and leads to abortion and infertility in ruminants and debilitating disease in humans. Jimma zone, including Jimma town, located in the Oromia region of Ethiopia, was affected by an outbreak of abortions in ruminants related to Q fever infection between 2013 and 2015. This study aimed to investigate the geo-clustering of seroprevalence in dairy farms of Jimma town and identify the environmental risk factors associated with seroprevalence distribution. Read More

View Article and Full-Text PDF

Correlating Genotyping Data of with Genomic Groups.

Pathogens 2021 May 14;10(5). Epub 2021 May 14.

Department of Biosciences, College of Life and Environmental Sciences-Biosciences, University of Exeter, Exeter EX4 4QD, UK.

is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans. Several distinct genetic lineages or genomic groups have been shown to exist, with evidence for different virulence potential of these lineages. Multispacer Sequence Typing (MST) and Multiple-Locus Variable number tandem repeat Analysis (MLVA) are being used to genotype strains. Read More

View Article and Full-Text PDF

One Health Approach: An Overview of Q Fever in Livestock, Wildlife and Humans in Asturias (Northwestern Spain).

Animals (Basel) 2021 May 13;11(5). Epub 2021 May 13.

Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.

This study aimed to investigate the seroprevalence of in domestic ruminants, wild ungulates, as well as the current situation of Q fever in humans in a small region in northwestern Spain where a close contact at the wildlife-livestock-human interface exists, and information on infection is scarce. Seroprevalence of was 8.4% in sheep, 18. Read More

View Article and Full-Text PDF

Utility of positron emission tomography imaging in the diagnosis of chronic Q fever: A Systematic Review.

J Med Imaging Radiat Oncol 2021 May 30. Epub 2021 May 30.

Pathology Queensland, Townsville University Hospital, Douglas, Queensland, Australia.

Chronic Q fever is a diagnostic challenge. Diagnosis relies on serology and/or the detection of DNA from blood or tissue samples. PET-CT identifies tissues with increased glucose metabolism, thus identifying foci of inflammation. Read More

View Article and Full-Text PDF

Q Fever Endocarditis: A Review of Local and all Reported Cases in the Literature.

Heart Lung Circ 2021 May 26. Epub 2021 May 26.

Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia; Harry Perkins Institute of Medical Research, University of Western Australia, Perth, WA, Australia. Electronic address:

Background: Q fever endocarditis by Coxiella burnetii is rare and presents a diagnostic challenge. With limited data available, the aim of this study was to review all reported cases together with unpublished local cases to understand risk factor profiles, diagnostic methods, clinical features, treatments and outcomes.

Methods: A search of the PubMed database using the term 'Q fever endocarditis' identified cases between 1950-2019. Read More

View Article and Full-Text PDF

Still new chronic Q fever cases diagnosed eight years after a large Q fever outbreak.

Clin Infect Dis 2021 May 24. Epub 2021 May 24.

Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Chronic Q fever usually develops within two years after primary infection with Coxiella burnetii. We determined the interval between acute Q fever and diagnosis of chronic infection, assessed what factors contribute to a longer interval, and evaluated the long-term follow-up.

Methods: From 2007-2018, patients with chronic Q fever were included from 45 participating hospitals. Read More

View Article and Full-Text PDF

F-Fluorodeoxyglucose positron emission tomography/computed tomography as a diagnostic and follow-up tool in endocarditis of prosthetic valve and aortic valved tube: a case report.

Eur Heart J Case Rep 2021 May 17;5(5):ytab159. Epub 2021 May 17.

Clinic of Emergency Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Background : European Society of Cardiology 2015 guidelines approved F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) as a useful diagnostic imaging technique in prosthetic valve endocarditis (PVE) and recent evidence seems to suggest a role of nuclear imaging in the follow-up of cardiovascular infections, but nowadays there are no sufficient data available.

Case Summary : A 67-year-old male presented with fever, weight loss, and fatigue. His medical history included ulcerative colitis and a previous Bentall-De Bono surgical procedure in 2014. Read More

View Article and Full-Text PDF

Infective endocarditis caused by on a prosthetic pulmonary valve with false positive serology for - The first described case.

IDCases 2021 3;24:e01146. Epub 2021 May 3.

Bacterial Zoonoses of Animals Unit, Veterinary Bacteriology, Sciensano, Brussels, Belgium.

We present a case of infective endocarditis (IE) on a prosthetic pulmonary valve in a 36-year-old patient with tetralogy of Fallot (TOF). The patient underwent valve replacement surgery and active antibiotic treatment against Gram-negative cocci (Piperacillin Tazobactam then Ceftriaxone) for a total duration of 42 days with a favourable outcome. The causative agent was which was identified on the infected valve by sequencing of 16S ribosomal RNA. Read More

View Article and Full-Text PDF

Hepatic Manifestations of Nonhepatotropic Infectious Agents Including Severe Acute Respiratory Syndrome Coronavirus-2, Adenovirus, Herpes Simplex Virus, and Coxiella burnetii.

Gastroenterol Clin North Am 2021 06 23;50(2):383-402. Epub 2021 Apr 23.

Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, University of Iowa, 200 Hawkins Drive, 4553 JCP, Iowa City, IA 52242, USA. Electronic address:

Nonhepatotropic viruses such as adenovirus, herpes simplex virus, flaviviruses, filoviruses, and human herpes virus, and bacteria such as Coxiella burnetii, can cause liver injury mimicking acute hepatitis. Most of these organisms cause a self-limited infection. However, in immunocompromised patients, they can cause severe hepatitis or in some cases fulminant hepatic failure requiring an urgent liver transplant. Read More

View Article and Full-Text PDF

Outbreaks of clinical toxoplasmosis in humans: five decades of personal experience, perspectives and lessons learned.

Jitender P Dubey

Parasit Vectors 2021 May 19;14(1):263. Epub 2021 May 19.

United States Department of Agriculture, Agricultural Research Service, Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Building 1001, Beltsville, MD, 20705-2350, USA.

Background: The protozoan parasite Toxoplasma gondii has a worldwide distribution and a very wide host range, infecting most warm-blooded hosts. Approximately 30% of humanity is infected with T. gondii, but clinical toxoplasmosis is relatively infrequent. Read More

View Article and Full-Text PDF

Coxiella burnetii and related tick endosymbionts evolved from pathogenic ancestors.

Genome Biol Evol 2021 May 19. Epub 2021 May 19.

Department of Biology and Center for Life in Extreme Environments, Portland State University, Portland, OR 97201, USA.

Both symbiotic and pathogenic bacteria in the family Coxiellaceae cause morbidity and mortality in humans and animals. For instance, Coxiella-like endosymbionts (CLEs) improve the reproductive success of ticks - a major disease vector, while Coxiella burnetii causes human Q fever, and uncharacterized coxiellae infect both animals and humans. To better understand the evolution of pathogenesis and symbiosis in this group of intracellular bacteria, we sequenced the genome of a CLE present in the soft tick Ornithodoros amblus (CLEOA) and compared it to the genomes of other bacteria in the order Legionellales. Read More

View Article and Full-Text PDF

Expression, purification and characterization of the IcmG and IcmK proteins of the type IVB secretion system from Coxiella burnetii.

Protein Expr Purif 2021 May 11;186:105905. Epub 2021 May 11.

Division of Biochemistry, Department of Chemistry, University of Crete, GR-71003, Voutes, Greece. Electronic address:

Coxiella burnetii, the causative agent of Q fever, is an intracellular bacterial pathogen. Studies on Coxiella have shown that a type IVB secretion system (T4BSS) contributes to the establishment of the infection by transferring protein molecules. In this report, we focus on two core proteins of the Coxiella T4BSS, namely the IcmG/DotF protein (CBU_1626) and the IcmK/DotH protein (CBU_1628). Read More

View Article and Full-Text PDF

The Prevalence of in Hard Ticks in Europe and Their Role in Q Fever Transmission Revisited-A Systematic Review.

Front Vet Sci 2021 26;8:655715. Epub 2021 Apr 26.

Institute of Bacterial Infections and Zoonoses (IBIZ), Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Jena, Germany.

The zoonosis Q fever is caused by the obligate intracellular bacterium . Besides the main transmission route inhalation of contaminated aerosols, ticks are discussed as vectors since the first isolation of the pathogen from a tick. The rare detection of in ticks and the difficult differentiation of from -like endosymbionts (CLEs) are questioning the relevance of ticks in the epidemiology of Q fever. Read More

View Article and Full-Text PDF

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211009385. Epub 2021 Apr 20.

Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Coronavirus disease 2019 (COVID-19) is a viral infection which can cause a variety of respiratory, gastrointestinal, and vascular symptoms. The acute illness phase generally lasts no more than 2-3 weeks. However, there is increasing evidence that a proportion of COVID-19 patients experience a prolonged convalescence and continue to have symptoms lasting several months after the initial infection. Read More

View Article and Full-Text PDF

Real-time PCR biochip for on-site detection of Coxiella burnetii in ticks.

Parasit Vectors 2021 May 6;14(1):239. Epub 2021 May 6.

Parasitic and Honeybee Disease Laboratory, Bacterial and Parasitic Disease Division, Department of Animal & Plant Health Research, Animal and Plant Quarantine Agency, Gimcheon, 39660, Republic of Korea.

Background: Q fever, a zoonosis caused by Coxiella burnetii, has adverse effects on public health. Ticks are vectors of C. burnetii and they contribute to the transmission of the pathogen. Read More

View Article and Full-Text PDF

Seroprevalence of Coxiella burnetii in patients presenting with acute febrile illness at Marigat District Hospital, Baringo County, Kenya.

Vet Med Sci 2021 May 6. Epub 2021 May 6.

United States Army Medical Research Directorate-Africa/Kenya, Walter Reed Army Institute of Research/Kenya Medical Research Institute, Kisumu, Kenya.

Q fever is not routinely diagnosed in Kenyan hospitals. This study reports on Q fever in patients presenting at Marigat District Hospital, Kenya, with febrile illness. ELISA was used to detect Coxiella burnetii phase antigens. Read More

View Article and Full-Text PDF

First Molecular Detection of Coxiella burnetii in Beef Cattle in West Java, Indonesia.

Jpn J Infect Dis 2021 Apr 30. Epub 2021 Apr 30.

Department of Veterinary Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, IPB University, Indonesia.

Coxiella burnetii (C. burnetii) is a bacterial agent causing Q fever which is widespread all over the world. Livestock such as cattle, goat, and sheep are the main sources of infection for this disease. Read More

View Article and Full-Text PDF

Molecular Detection of Coxiella burnetii in Unstandardized Minas Artisanal Cheese Marketed in Southeastern Brazil.

Acta Trop 2021 May 2;220:105942. Epub 2021 May 2.

Department of Veterinary Pathobiology and Theriogenology Faculdade de Ciências Agrárias e Veterinárias (FCAV) - UNESP Jaboticabal, São Paulo, Brasil. Electronic address:

Q fever is a zoonotic disease caused by Coxiella burnetii. The causative pathogen has been detected in dairy products, which raises the possibility of consumption of dairy products as a possible route of transmission; however, this has not been adequately described. Therefore, the aim of the present study was to investigate the presence of C. Read More

View Article and Full-Text PDF

A randomised controlled trial of the immunogenicity and safety of a formaldehyde-inactivated Coxiella burnetii vaccine in 8-week-old goats.

Vet Immunol Immunopathol 2021 Jun 25;236:110253. Epub 2021 Apr 25.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.

Coxiella burnetii causes Q fever in individuals exposed to infected ruminants. Vaccination in 3-4-month-old goats, has been reported to result in significantly greater reduction in C. burnetii shedding compared to goats vaccinated one month before breeding, the most commonly used strategy of controlling Q fever on infected intensively-managed herds. Read More

View Article and Full-Text PDF

Epidemiological study of Coxiella burnetii in dairy cattle and small ruminants in Québec, Canada.

Prev Vet Med 2021 Apr 25;191:105365. Epub 2021 Apr 25.

Groupe de recherche en épidémiologie des zoonoses et santé publique (GREZOSP), Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte, St-Hyacinthe, Québec, J2S 2M2, Canada; Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte, St-Hyacinthe, Québec, J2S 2M2, Canada; Swine and Poultry Infectious Diseases Research Center (CRIPA) - Fonds de Recherche du Québec, Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte, St-Hyacinthe, Québec, J2S 2M2, Canada. Electronic address:

The bacterium Coxiella burnetii (C. burnetii) can infect a wide range of animals, most notably ruminants where it causes mainly asymptomatic infections and, when clinical, it is associated with reproductive disorders such as abortion. It is also the etiological agent of Q fever in humans, a zoonosis of increasingly important public health concern. Read More

View Article and Full-Text PDF

National Seroprevalence of in Chile, 2016-2017.

Pathogens 2021 Apr 28;10(5). Epub 2021 Apr 28.

Bacteriology, Sub-department of Infectious Diseases, Department Biomedical Laboratory, Public Health Institute of Chile, Santiago 7780050, Chile.

is an intracellular bacterium and the cause of the zoonotic infection, Q fever. National surveillance data on seroprevalence is currently not available for any South American country, making efforts of public health to implement strategies to mitigate infections in different at-risk groups within the population extremely challenging. In the current study, we used two commercial anti- immunoassays to screen sera collected from a sample of the Chilean population as part of a 2016-2017 national health survey ( = 5166), nationwide and age-standardized. Read More

View Article and Full-Text PDF

Rapid Molecular Diagnostic Sensor Based on Ball-Lensed Optical Fibers.

Biosensors (Basel) 2021 Apr 15;11(4). Epub 2021 Apr 15.

Medical Device Development Center, Osong Medical Innovation Foundation, 123 Osongsaengmyung-ro, Heungdeok-gu, Cheongju-si 28160, Korea.

Given the fatal health conditions caused by emerging infectious pathogens, such as severe acute respiratory syndrome coronavirus 2, their rapid diagnosis is required for preventing secondary infections and guiding correct treatments. Although various molecular diagnostic methods based on nucleic acid amplification have been suggested as gold standards for identifying different species, these methods are not suitable for the rapid diagnosis of pathogens owing to their long result acquisition times and complexity. In this study, we developed a rapid bio-optical sensor that uses a ball-lensed optical fiber (BLOF) probe and an automatic analysis platform to precisely diagnose infectious pathogens. Read More

View Article and Full-Text PDF

Antibodies Related to sensu lato, and Detected in Serum and Heart Rinses of Wild Small Mammals in the Czech Republic.

Pathogens 2021 Apr 1;10(4). Epub 2021 Apr 1.

Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.

Wild small mammals are the most common reservoirs of pathogenic microorganisms that can cause zoonotic diseases. The aim of the study was to detect antibodies related to sensu lato, and in wild small mammals from the Czech Republic. In total, sera or heart rinses of 211 wild small mammals (168 , 28 , 9 , and 6 ) were examined by modified enzyme-linked immunosorbent assay. Read More

View Article and Full-Text PDF

Emerging and Re-emerging Infectious Diseases in the WHO Eastern Mediterranean Region, 2001-2018.

Int J Health Policy Manag 2021 Mar 6. Epub 2021 Mar 6.

Department of Primary Care and Public Health, School of Public Health, Faculty of Medicine, Imperial College, London, UK.

Background: Countries in the World Health Organization (WHO) Eastern Mediterranean Region (EMR) are predisposed to highly contagious, severe and fatal, emerging infectious diseases (EIDs), and re-emerging infectious diseases (RIDs). This paper reviews the epidemiological situation of EIDs and RIDs of global concern in the EMR between 2001 and 2018.

Methods: To do a narrative review, a complete list of studies in the field was we prepared following a systematic search approach. Read More

View Article and Full-Text PDF

Multiple mononeuritis with peripheral blood eosinophilia in a patient with Q fever: An unusual presentation: Case report and review of the literature.

J Infect Chemother 2021 Apr 23. Epub 2021 Apr 23.

Department of Internal Medicine, Evangelismos General Hospital, 45 - 47 Ypsilantou St, 10676, Athens, Greece.

Coxiella burnetii is a gram-negative bacterium that typically lives and multiplies within monocytes and macrophages of the host, being the etiologic agent of the zoonosis Q fever. Q fever is usually divided into acute and chronic forms, with a significant percentage of patients being asymptomatic. In the wide spectrum of the disease, neurological involvement seems to be extremely rare and peripheral neuropathy presenting with mononeuritis multiplex is one of the possible presentations with low rates of occurrence. Read More

View Article and Full-Text PDF