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    1 OF 105

    Estimating the incubation period of acute Q fever, a systematic review.
    Epidemiol Infect 2018 Mar 21:1-8. Epub 2018 Mar 21.
    Field Epidemiology Service, National Infection Service,Public Health England,West Midlands,UK.
    Estimates of the incubation period for Q fever vary substantially between different reviews and expert advice documents. We systematically reviewed and quality appraised the literature to provide an evidence-based estimate of the incubation period of the Q fever by the aerosolised infection route. Medline (OVIDSP) and EMBASE were searched with the search limited to human studies and English language. Read More

    Epidemiology of Q-fever in goats in Hubei province of China.
    Trop Anim Health Prod 2018 Mar 20. Epub 2018 Mar 20.
    University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
    Coxiella burnetii (C. burnetii) is an intracellular bacterium, which causes zoonotic disease called Q-fever. However, scarce information is known about the epidemiology of Q-fever in goats in Hubei province of China. Read More

    Coxiella burnetii endocarditis on bioprosthetic aortic valve, with peripheral arterial embolism.
    Cardiovasc Pathol 2018 Feb 16;34:38-39. Epub 2018 Feb 16.
    Department of Nephrology, AP-HP, Hôpital Européen Georges Pompidou, F-75015 Paris, France.
    Acute limb ischemia related to Coxiella burnetii endocarditis is rare. We report an original case of a 68-year-old man hospitalized for recurrent acute left limb ischemia in a context of atrial flutter, which revealed C. burnetii endocarditis. Read More

    Herd prevalence and genotypes of Coxiella burnetii in dairy cattle bulk tank milk in Gyeongsang provinces of South Korea.
    Trop Anim Health Prod 2018 Mar 16. Epub 2018 Mar 16.
    College of Veterinary Medicine, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea.
    Coxiella burnetii is the causative agent of the zoonotic Q fever, and its reservoirs include ticks and livestock, which are key sources of transmission to humans. Although there have been several studies on the prevalence of C. burnetii antibodies in dairy cattle bulk tank milk (BTM), there is a lack of information on the molecular detection of C. Read More

    Q fever in Spain: Description of a new series, and systematic review.
    PLoS Negl Trop Dis 2018 Mar 15;12(3):e0006338. Epub 2018 Mar 15.
    Department of Internal Medicine, University Teaching Hospital, Santiago de Compostela, A Coruña, Spain.
    Background: Forms of presentation of Q fever vary widely across Spain, with differences between the north and south. In the absence of reported case series from Galicia (north-west Spain), this study sought to describe a Q-fever case series in this region for the first time, and conduct a systematic review to analyse all available data on the disease in Spain.

    Methods: Patients with positive serum antibodies to Coxiella burnetii from a single institution over a 5-year period (January 2011-December 2015) were included. Read More

    Beginning to Understand the Role of the Type IV Secretion System Effector Proteins in Coxiella burnetii Pathogenesis.
    Curr Top Microbiol Immunol 2017 ;413:243-268
    Institut de Recherche En Infectiologie de Montpellier (IRIM), CNRS, UMR9004, Université de Montpellier, Montpellier, France.
    Coxiella burnetii is the etiological agent of the zoonotic disease Q fever, which manifests in severe outbreaks and is associated with important health and economic burden. Moreover, C. burnetii belongs to the list of class B bioterrorism organisms, as it is an airborne and highly infective pathogen with remarkable resistance to environmental stresses. Read More

    A contemporary 16-year review of Coxiella burnetii infective endocarditis in a tertiary cardiac center in Queensland, Australia.
    Infect Dis (Lond) 2018 Mar 8:1-8. Epub 2018 Mar 8.
    c Health Support Queensland Pathology Queensland , Herston , Australia.
    Background: Coxiella burnetii endocarditis can be difficult to diagnose leading to delays in treatment. This retrospective case series study was undertaken to understand the epidemiologic trends and clinical features of Q fever endocarditis in Southeast Queensland, Australia.

    Methods: Clinical records of patients from a single center with coding diagnosis of C. Read More

    Seroprevalence ofantibodies and chronic Q fever among post-mortal and living donors of tissues and cells from 2010 to 2015 in the Netherlands.
    Euro Surveill 2018 Mar;23(9)
    Sanquin Plasma Products, Amsterdam (previously BISLIFE Foundation, Leiden), The Netherlands.
    BackgroundAfter a large Q fever outbreak in the Netherlands in the period from 2007 to 2010, the risk of Q fever transmission through tissue and cell transplantation from undiagnosed chronic Q fever cases became a potential issue.We aimed to evaluate the risk of Q fever transmission through tissue and cell transplantation.We performed a retrospective observational cohort study among 15,133 Dutch donors of tissues and stem cells from 2010 to 2015 to assess seroprevalence ofantibodies, to identify factors associated with presence ofantibodies, and to assess the proportion of undiagnosed chronic Q fever cases. Read More

    Exploratory investigation of Q fever in apparently healthy meat sheep flocks in Belgium.
    Transbound Emerg Dis 2018 Mar 2. Epub 2018 Mar 2.
    Faculty of Veterinary Medicine, Research Unit for Epidemiology and Risk Analysis applied to Veterinary Sciences (UREAR-ULiège), Fundamental and Applied Research for Animals & Health (FARAH) Center, University of Liège, Liège, Belgium.
    Q fever is a cosmopolitan disease affecting both humans and many animal species. Although sheep are often implicated in human Q fever outbreaks, the disease remains largely underestimated in meat sheep flocks. In order to fulfil this gap, a preliminary study was performed aiming to investigate the serological and molecular aspects of infection with Coxiella burnetii among meat sheep flocks in Belgium. Read More

    subverts p62/SQSTM-1 and activates Nrf2 signaling in human macrophages.
    Infect Immun 2018 Feb 26. Epub 2018 Feb 26.
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205
    is the causative agent of human Q fever, a debilitating flu-like illness that can progress to chronic disease presenting as endocarditis. Following inhalation,is phagocytosed by alveolar macrophages and generates a lysosome-like replication compartment termed the parasitophorous vacuole (PV). A type IV secretion system (T4SS) is required for PV generation and is one of the pathogen's few known virulence factors. Read More

    Genetic mechanisms of Coxiella burnetii lipopolysaccharide phase variation.
    PLoS Pathog 2018 Mar 26;14(3):e1006922. Epub 2018 Feb 26.
    Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.
    Coxiella burnetii is an intracellular pathogen that causes human Q fever, a disease that normally presents as a severe flu-like illness. Due to high infectivity and disease severity, the pathogen is considered a risk group 3 organism. Full-length lipopolysaccharide (LPS) is required for full virulence and disease by C. Read More

    On the possible role of ticks in the eco-epidemiology of Coxiella burnetii in a Mediterranean ecosystem.
    Ticks Tick Borne Dis 2018 Mar 21;9(3):687-694. Epub 2018 Feb 21.
    Wildlife Ecology & Health group (WEH) and Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona, Spain; Departament de Ciència Animal, Escola Tècnica Superior d'Enginyeria Agraria (ETSEA), Universitat de Lleida (UdL), Lleida, Spain. Electronic address:
    Ruminant livestock is the main reservoir of Coxiella burnetii (Cb), but little is known about the role of wildlife and ticks in its epidemiology. The Iberian ibex (Capra pyrenaica, Schinz 1838) population of "Ports de Tortosa i Beseit" (NE Spain) suffers intense tick infestations and low reproduction rates. This study aims to (1) assess the relationship between infection in ibexes (detection of serum antibodies and/or of Cb DNA in tissues) and Cb DNA presence in ticks hosted by the same ibexes; and (2) identify Cb associated risk factors. Read More

    Should acute Q-fever patients be screened for valvulopathy to prevent endocarditis?
    Clin Infect Dis 2018 Feb 20. Epub 2018 Feb 20.
    Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
    Background: Echocardiographic screening of acute Q-fever patients and antibiotic prophylaxis for patients with cardiac valvulopathy are considered an important approach to prevent chronic Q-fever-related endocarditis. During a large Q-fever epidemic in the Netherlands, routine screening echocardiography was discontinued, raising controversy in the international literature. We followed a cohort of acute Q-fever patients to estimate the risk for developing chronic Q-fever, and we evaluated the impact of screening in patients who were not yet known to have a valvulopathy. Read More

    Q fever in Egypt: Epidemiological survey of Coxiella burnetii specific antibodies in cattle, buffaloes, sheep, goats and camels.
    PLoS One 2018 21;13(2):e0192188. Epub 2018 Feb 21.
    Mansoura Provincial Laboratory, Institute of Animal Health Research, Mansoura, Egypt.
    Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. Clinical presentation in humans varies from asymptomatic to flu-like illness and severe sequelae may be seen. Ruminants are often sub-clinically infected or show reproductive disorders such as abortions. Read More

    Serosurvey ofin high risk population in Turkey, endemic to Crimean-Congo haemorrhagic fever virus.
    J Vector Borne Dis 2017 Oct-Dec;54(4):341-347
    Vocational School of Health Services, Cumhuriyet University, Sivas, Turkey.
    Background & Objectives: Q fever caused by Coxiella burnetii is a zoonotic infection that spreads to human beings from animals. This study was aimed to demographically examine the C. burnetii seroprevalence in the people living in villages where Crimean-Congo haemorrhagic fever virus (CCHFV) is endemic, in terms of various risk factors such as tick bites, tick contact, and occupational groups. Read More

    Q fever endocarditis after right ventricle to pulmonary artery conduit insertion: Case series and review of the literature.
    Ann Pediatr Cardiol 2018 Jan-Apr;11(1):60-63
    Department of Pediatric Cardiology, Chest Diseases Hospital, Ministry of Health, Kuwait City, Kuwait.
    Q fever (QF) is rarely reported in children. Awareness of the disease and newer diagnostic modalities have resulted in increasing recognition of unusual manifestations. We present three cases of QF endocarditis after right ventricle to pulmonary artery conduit insertion in children. Read More

    Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area.
    Vet Microbiol 2018 Feb 13;215:49-56. Epub 2017 Nov 13.
    University of Lyon, VetAgroSup, Marcy L'Etoile, France; EPIA, UMR 0346, Epidemiologie des maladies animales et zoonotiques, INRA, VetAgroSup, 63122 Saint-Genès Champanelle, France. Electronic address:
    Coxiella burnetii can infect many animal species, but its circulation dynamics in and through horses is still unclear. This study evaluated horse exposure in an area known to be endemic for ruminants and humans. We assessed antibody prevalence in horse serum by ELISA, and screened by qPCR horse blood, ticks found on horses and dust from stables. Read More

    A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis.
    Int J Infect Dis 2018 Mar 2;69:50-54. Epub 2018 Mar 2.
    Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.
    A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen onF-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Read More

    Q fever epidemic in Cayenne, French Guiana, epidemiologically linked to three-toed sloth.
    Comp Immunol Microbiol Infect Dis 2018 Feb 9;56:34-38. Epub 2018 Jan 9.
    Aix-Marseille Université, URMITE, Marseille, France.
    A Q fever epidemic occurred in 2013 in a small military residential area in Cayenne, French Guiana. A retrospective cohort study was conducted to identify Q fever risk factors. Confirmed acute Q fever case was defined as positive serology (IgM ≥ 50 and phase II IgG ≥ 200) and/or positive qPCR on serum or blood. Read More

    Management of community-acquired pneumonia in adults: 2016 guideline update from the Dutch Working Party on Antibiotic Policy (SWAB) and Dutch Association of Chest Physicians (NVALT).
    Neth J Med 2018 Jan;76(1):4-13
    Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
    The Dutch Working Party on Antibiotic Policy in collaboration with the Dutch Association of Chest Physicians, the Dutch Society for Intensive Care and the Dutch College of General Practitioners have updated their evidence-based guidelines on the diagnosis and treatment of community-acquired pneumonia (CAP) in adults who present to the hospital. This 2016 update focuses on new data on the aetiological and radiological diagnosis of CAP, severity classification methods, initial antibiotic treatment in patients with severe CAP and the role of adjunctive corticosteroids. Other parts overlap with the 2011 guideline. Read More

    Interaction ofStrains of Different Sources and Genotypes with Bovine and Human Monocyte-Derived Macrophages.
    Front Cell Infect Microbiol 2017 12;7:543. Epub 2018 Jan 12.
    Friedrich-Loeffler-Institut, Institute of Molecular Pathogenesis, Jena, Germany.
    Most human Q fever infections originate from small ruminants. By contrast, highly prevalent shedding of(.)by bovine milk rarely results in human disease. Read More

    [Concurrent malaria and rickettsiosis in a patient returning from the Republic of South Africa].
    Klin Mikrobiol Infekc Lek 2017 Dec;23(4):142-147
    Department of Infectious Diseases, Faculty of Medicine in Hradec Kralove, Charles University, Czech Republic, e-mail:
    Definitive diagnosis and therapy proved challenging in the case of a 60-year-old male with malaria and rickettsiosis. Returning travellers who are unwell can present practical difficulties in diagnosis and treatment and the focus here is on conditions relevant to the Republic of South Africa. Malaria, rickettsiosis and Q fever are discussed. Read More

    Unreliability of three commercialphase II IgM ELISA kits for the seroscreening of acute Q fever in human cases.
    Indian J Med Res 2017 09;146(3):386-391
    Department of Microbiology, Indira Gandhi Government General Hospital & Post Graduate Institute, Puducherry, India.
    Background & Objectives: Seroprevalence of Q fever (QF) caused by Coxiella burnetii has been reported from different parts of India. Usually serological/molecular tests are employed for detection of infection. The present study was undertaken to verify the validity of three different QF phase II IgM ELISA kits for acute QF diagnosis by comparing with the gold standard indirect fluorescent antibody assay (IFA). Read More

    Draft Genome Sequence ofHistorical Strain Leningrad-2, Isolated from Blood of a Patient with Acute Q Fever in Saint Petersburg, Russia.
    Genome Announc 2018 Jan 18;6(3). Epub 2018 Jan 18.
    Almazov National Medical Research Centre, Saint Petersburg, Russia.
    This is the announcement of a draft genome sequence ofstrain Leningrad-2, phase I. The strain, which is mildly virulent in infected guinea pigs, was isolated in 1957 from the blood of a patient with acute Q fever in Leningrad (now Saint Petersburg), Russia. Read More

    First molecular detection and genetic characterization of Coxiella burnetii in Zambian dogs and rodents.
    Parasit Vectors 2018 Jan 17;11(1):40. Epub 2018 Jan 17.
    Department of Paraclinical studies, School of Veterinary Medicine, University of Zambia, PO Box 32379, 10101, Lusaka, Zambia.
    Coxiella burnetii, the causative agent of Q fever, is a zoonotic pathogen associated with sylvatic or domestic transmission cycles, with rodents being suspected to link the two transmission cycles. Infection and subsequent disease in humans has historically been associated with contact with infected livestock, especially sheep. However, recently there have been reports of Q fever outbreaks associated with contact with infected rodents and dogs. Read More

    The First Serological Study of Q Fever in Humans in Lebanon.
    Vector Borne Zoonotic Dis 2018 Mar 16;18(3):138-143. Epub 2018 Jan 16.
    2 Doctoral School of Sciences and Technology, Lebanese University , Beirut, Lebanon .
    Objective: The aim of this study was to estimate, for the first time, the human seroprevalence of Q fever in Lebanon, by assessing the presence of antibodies against the causative agent, Coxiella burnetii. A total number of 421 serum samples (226 females and 196 males) were collected in February 2015 from hospitals and laboratories dispersed in five Lebanese provinces: Akkar, Bekaa, Mount Lebanon, Nabatieh, and South Lebanon.

    Methods: Serial testing approach was used. Read More

    Seroprevalence of Q Fever Among the Indigenous People (Orang Asli) of Peninsular Malaysia.
    Vector Borne Zoonotic Dis 2018 Mar 16;18(3):131-137. Epub 2018 Jan 16.
    1 Tropical Infectious Diseases Research & Education Centre (TIDREC), University of Malaya , Kuala Lumpur, Malaysia .
    Q fever is a disease caused by Coxiella burnetii. It is a disease of public health concern in many parts of the world. In this study, we described the seroprevalence of Q fever among selected populations of Orang Asli (OA), indigenous people, many of whom live within the forest fringe areas of Peninsular Malaysia. Read More

    Antemortem Diagnosis of Coxiellosis in a Blue and Gold Macaw ( Ara ararauna).
    J Avian Med Surg 2017 Dec;31(4):364-372
    A 15-year-old female blue and gold macaw ( Ara ararauna) was presented for evaluation after being found laterally recumbent, reluctant to move, and lethargic. Results of a complete blood count showed an increased number of immature heterophils with increased cytoplasmic basophilia and degranulation and the presence of a left shift. Radiographs and a computed tomography scan were performed and revealed a markedly enlarged spleen. Read More

    The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever.
    J Antimicrob Chemother 2018 Apr;73(4):1068-1076
    Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
    Background: First choice treatment for chronic Q fever is doxycycline plus hydroxychloroquine. Serum doxycycline concentration (SDC) >5 μg/mL has been associated with a favourable serological response, but the effect on clinical outcomes is unknown.

    Objectives: To assess the effect of measuring SDC during treatment of chronic Q fever on clinical outcomes. Read More

    Farming, Q fever and public health: agricultural practices and beyond.
    Arch Public Health 2018 6;76. Epub 2018 Jan 6.
    Department of Bacteriology and Epidemiology, Wageningen Bioveterinary Research, Lelystad, the Netherlands.
    Since the Neolithic period, humans have domesticated herbivores to have food readily at hand. The cohabitation with animals brought various advantages that drastically changed the human lifestyle but simultaneously led to the emergence of new epidemics. The majority of human pathogens known so far are zoonotic diseases and the development of both agricultural practices and human activities have provided new dynamics for transmission. Read More

    The Resistance to Plague Infection amongfrom Endemic and Non-endemic Regions in Iran: The Role of Gut Microbiota.
    Iran J Public Health 2018 Jan;47(1):86-94
    School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Background: The present study was conducted approximately 40 years ago, but its results have not been released. At the time of this study, the importance of the gut microbiota was not fully understood.

    Methods: rodents, as one of the major reservoirs ofbacterium in Iran, were compared in a disease endemic area (Akanlu, Hamadan, western Iran) and a non-endemic zone (Telo, Tehran, Iran) from 1977 to 1981. Read More

    Tache Noire in a Patient with Acute Q Fever.
    Med Princ Pract 2018 Jan 3. Epub 2018 Jan 3.
    Objective: To describe a rare case of acute Q fever with tache noire.

    Clinical Presentation And Intervention: A 51 year-old man experienced an acute Q fever showing a tache noire, generally considered a pathognomonic sign of Mediterranean spotted fever (MSF) and MSF-like illness, but not a clinical feature of Q fever. The patient was treated with doxycycline 100 mg every 12 hours. Read More

    Phylogenetic inference of Coxiella burnetii by 16S rRNA gene sequencing.
    PLoS One 2017 29;12(12):e0189910. Epub 2017 Dec 29.
    Laboratory Preparedness and Response Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
    Coxiella burnetii is a human pathogen that causes the serious zoonotic disease Q fever. It is ubiquitous in the environment and due to its wide host range, long-range dispersal potential and classification as a bioterrorism agent, this microorganism is considered an HHS Select Agent. In the event of an outbreak or intentional release, laboratory strain typing methods can contribute to epidemiological investigations, law enforcement investigation and the public health response by providing critical information about the relatedness between C. Read More

    Serological prevalence of Coxiella burnetii in dairy goats and ewes diagnosed with adverse pregnancy outcomes in Greece.
    Ann Agric Environ Med 2017 Dec 19;24(4):702-705. Epub 2017 Dec 19.
    Laboratory of Animal Husbandry, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece.
    Introduction: Coxiella burnetii is an obligatory intracellular bacterial pathogen causing the zoonotic disease Q fever. The most common reservoirs of C. burnetii are wild mammals, birds and ticks. Read More

    Estimating the Efficacy of a Commercial Phase I Inactivated Vaccine in Decreasing the Prevalence ofInfection and Shedding in Red Deer ().
    Front Vet Sci 2017 6;4:208. Epub 2017 Dec 6.
    Health and Biotechnology (SaBio) Group, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, Spain.
    The red deer () is a relevant reservoir forin Iberia.genotypes that infect red deer also infect humans and domestic animals. Integrated control approaches that target both domestic and wild ruminants are, therefore, required to reduceinfection risks in Iberia, especially in wildlife-livestock-human interaction scenarios. Read More

    Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass.
    Case Rep Pathol 2017 15;2017:4076159. Epub 2017 Nov 15.
    Departments of Pathology, UC Irvine Medical Center, UC Irvine School of Medicine, Orange, CA, USA.
    Background: Q fever is an infection caused by, an intracellular organism. Acute infection is most often a benign and asymptomatic process; however, some individuals may go on to develop subacute and persistent localized symptomatic Q fever. As such, the clinical and histopathologic findings of Q fever are widely variable and may be missed if clinical suspicion is not high. Read More

    Pulmonary manifestations of Q fever: analysis of 38 patients.
    J Thorac Dis 2017 Oct;9(10):3973-3978
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, Minnesota, USA.
    Background: Lung involvement in both acute and chronic Q fever is not well described with only a few reported cases of pseudotumor or pulmonary fibrosis in chronic Q fever. The aim of this study was to better understand the pulmonary manifestations of Q fever.

    Methods: We conducted a retrospective cohort study of patients with diagnosis of Q fever at Mayo Clinic Rochester. Read More

    Understanding Q Fever Risk to Humans in Minnesota Through the Analysis of Spatiotemporal Trends.
    Vector Borne Zoonotic Dis 2018 Feb 20;18(2):89-95. Epub 2017 Dec 20.
    1 Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota , St Paul, Minnesota.
    Q fever is a widely distributed, yet, neglected zoonotic disease, for which domestic ruminants are considered the main reservoirs in some countries. There are still many gaps in our knowledge of its epidemiology, and the source of sporadic cases is often not determined. In this study, we show how Q fever surveillance data in combination with information routinely collected by government agencies in Minnesota during 1997 to 2015 can be used to characterize patterns of occurrence of Q fever illnesses and detect variables potentially associated with increased human illness. Read More

    Epidemiology of Q fever in Iran: A systematic review and meta-analysis for estimating serological and molecular prevalence.
    J Res Med Sci 2017 28;22:121. Epub 2017 Nov 28.
    Department of Epidemiology, Pasteur Institute of Iran, Tehran, Iran.
    Background: Q fever is endemic in Iran, thus, we conducted a systematic review and meta-analysis on epidemiology ofamong humans and animals in Iran.

    Materials And Methods: A systematic search was performed to identify all articles reportingprevalence in Iranian humans or animals, published from January 2000 to January 2015. Data from articles were extracted, and a pooled estimate of prevalence with corresponding 95% confidence interval (CI) was calculated using random effect method. Read More

    Coxiella burnetii infection (Q fever) mimicking systemic lupus erythematosus: two cases.
    Lupus 2017 Jan 1:961203317747721. Epub 2017 Jan 1.
    1 Service de Médecine Interne, Centre Hospitalier Lyon Sud, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France.
    Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lupus erythematosus. Read More

    Risk of exposure to Coxiella burnetii from ruminant livestock exhibited at Iowa agricultural fairs.
    Zoonoses Public Health 2017 Dec 17. Epub 2017 Dec 17.
    Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
    Coxiella burnetii is a zoonotic pathogen typically associated with clinical and asymptomatic infection in ruminant livestock. A re-emerging pathogen of significant public health importance, C. burnetii has caused recent epidemics in the United States and Europe, and public livestock exhibitions are increasingly scrutinized as a potential source of C. Read More

    Seroepidemiological study of Q fever in Lorestan province, western Iran, 2014.
    Iran J Microbiol 2017 Aug;9(4):213-218
    Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.
    Background And Objectives: Q fever is a zoonotic disease and farm animals serve as the main reservoir of the disease. The aim of this study was to evaluate the seroprevalence of Q fever in sheep, in Lorestan province in western Iran.

    Materials And Methods: In this cross-sectional study, 330 blood samples were collected from sheep, from each county in Lorestan province. Read More

    Emerging and re-emerging infectious diseases in Iran.
    Iran J Microbiol 2017 Jun;9(3):122-142
    Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.
    Despite development of preventive and controlling strategies regarding infectious diseases, they are still considered as one of the most significant leading causes of morbidity and mortality, worldwide. Changes in humans' demographics and behaviors, microbial and ecological alterations, agricultural development, international travels and susceptibility to infectious diseases have resulted in increased reports of emerging infectious diseases (EIDs) and reemerging infectious diseases (RIDs) in various geographical areas. Because of the various types of geographic properties in Iran, substantial climatic variability, as well as unstable political situations and poor public health conditions in some of neighboring countries, EIDs and RIDs are serious public health problems; among them, zoonotic and drug resistant diseases are the most significant. Read More

    Diagnosis of Acute Q Fever by Detection ofDNA using Real-Time PCR, Employing a Commercial Genesig Easy Kit.
    J Clin Diagn Res 2017 Sep 1;11(9):DC10-DC13. Epub 2017 Sep 1.
    Professor, Department of Paediatrics, Mahatma Gandhi Medical College and Research Institute, SBV University, Pillaiyarkuppam, Puducherry, India.
    Introduction: Query (Q) fever is an important zoonosis and a cause of concern for humans, due to the potential bioterrorism threat posed by the causative agent,. Because of the danger of contracting the illness, isolation attempts are seldom made. Serological and molecular diagnostic tests are the main option. Read More

    Mechanisms of action of Coxiella burnetii effectors inferred from host-pathogen protein interactions.
    PLoS One 2017 27;12(11):e0188071. Epub 2017 Nov 27.
    Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America.
    Coxiella burnetii is an obligate Gram-negative intracellular pathogen and the etiological agent of Q fever. Successful infection requires a functional Type IV secretion system, which translocates more than 100 effector proteins into the host cytosol to establish the infection, restructure the intracellular host environment, and create a parasitophorous vacuole where the replicating bacteria reside. We used yeast two-hybrid (Y2H) screening of 33 selected C. Read More

    Seroprevalence of rickettsial infections and Q fever in Bhutan.
    PLoS Negl Trop Dis 2017 Nov 27;11(11):e0006107. Epub 2017 Nov 27.
    Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.
    Background: With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever.

    Methodology: A descriptive cross-sectional serosurvey was conducted from January to March 2015 in eight districts of Bhutan. Read More

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