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BMC Infect Dis 2021 Jun 2;21(1):518. Epub 2021 Jun 2.

Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14080, Mexico City, Mexico.

Background: Lactobacillus is a genus of Gram-positive non-spore-forming rods usually found in the microbiota of the oral cavity, gastrointestinal tract, and female genitourinary tract. Also, they are commonly used in the food industry as supplements and probiotics. Lactobacilli are normally considered non-pathogenic to the human body, however, under certain circumstances such as immunosuppression, they can cause severe infections, with only a few cases of bacteremia, infective endocarditis, pneumonia, meningitis, and intra-abdominal infections reported. Read More

Front Med (Lausanne) 2021 12;8:675345. Epub 2021 May 12.

Graduate Institute of Biomedical Sciences Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.

To date, no comprehensive epidemiological study exists on pyogenic liver abscess (PLA) risk in patients with newly diagnosed type 2 diabetes mellitus (T2DM) worldwide. We conducted a retrospective cohort study by using data from Taiwan National Health Insurance Research Database (NHIRD) to examine the association between newly diagnosed T2DM and PLA. The T2DM cohort included patients newly diagnosed as having T2DM (ICD-9-CM:250) from 2000 to 2009, with follow-up until December 31, 2011. Read More

Rev Esp Geriatr Gerontol 2021 May 22. Epub 2021 May 22.

Servicio de Medicina Interna y Geriatría. Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España. Electronic address:

IDCases 2021 7;24:e01150. Epub 2021 May 7.

Department of Medicine - Infectious Disease, Saint Francis Hospital and Medical Center, Hartford, CT, 06105, United States.

is an uncommon gram-negative bacterium that has rarely been identified as the causative organism in severe infections. Few cases have been described and have included patients with pneumonia, urinary tract infections or cholangitis. Only one case has reported to involve a liver abscess, thought to be from a primary urologic source. Read More

Am J Med 2021 May 16. Epub 2021 May 16.

All authors affiliated with Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030.

J Clin Exp Hepatol 2021 May-Jun;11(3):312-320. Epub 2020 Oct 15.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.

Background: The management practices of liver abscess (LA) have evolved over time. The precise diagnosis of etiology and complications is pivotal for appropriate management.

Methods: Descriptive analyses of consecutive patients treated for LA using electronic medical records at a liver unit between years 2010 and 2020 and investigate relationships between clinical, imaging, laboratory and microbiological findings, treatment strategies and mortality. Read More

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Internal Medicine, Michigan State University, East Lansing, Michigan, USA.

, a non-fermenting gram-negative bacterium, is emerging as an important multidrug resistant opportunistic pathogen. It has been described in cases of bacteremia, pleuritis, keratitis and peritoneal dialysis-associated peritonitis. We describe, for the first time, a case of pyogenic liver abscess caused by coinfection of and , and briefly review pyogenic liver abscesses and the literature regarding . Read More

Liver Int 2021 May 9. Epub 2021 May 9.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

IDCases 2021 16;24:e01125. Epub 2021 Apr 16.

Department of General Medicine, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.

We report an uncommon case of pyogenic liver abscess due to in an apparently immune-competent individual, the timely recognition of which could avoid a potentially fatal course of infection in the patient. A 45-year-old man, with history of moderate alcohol intake since the last 10 years, was admitted with intense right-sided upper abdominal pain and right-sided chest pain of 10-days duration. Culture of the ultrasound-guided liver aspirate sample yielded a pure growth of identified by the VITEK-2™ automated microbial identification system. Read More

BMC Emerg Med 2021 May 3;21(1):58. Epub 2021 May 3.

Department of Emergency, Shanghai Jiao Tong University School of Medicine affiliated Renji Hospital, 2000 Jiangyue Road, Minhang District, Shanghai, 200025, China.

Background: Highly empiric use of carbapenem in pyogenic liver abscess (PLA) is widespread problem. However, few studies have examined the association between blood culture and carbapenem use in patients with PLA in China. Thus, we conducted this observational study. Read More

Case Rep Infect Dis 2021 9;2021:8896379. Epub 2021 Apr 9.

St. Vincent's Medical Center, Bridgeport, CT, USA.

liver abscess (KPLA) is an emerging syndrome with the initial cases described in Taiwan in the 1980s. There is high mortality with this condition, and immediate aggressive treatment is necessary. Diabetes mellitus (D. Read More

Zhonghua Gan Zang Bing Za Zhi 2021 Mar;29(3):275-278

Department of Gastroenterology, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Pyogenic liver abscess (PLA) accompanied by occult malignant tumors is a rare kind of life-threatening disease. Studies have shown that it can predict the occurrence of cancer, especially hepatobiliary and colorectal cancer. The risk of combined occult primary liver cancer, cholangiocarcinoma, and gastrointestinal cancer is high in PLA patients. Read More

Bioact Mater 2021 Nov 10;6(11):3812-3823. Epub 2021 Apr 10.

Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Pyogenic liver abscess and keratitis are aggressive bacterial infections and the treatment has failed to eradicate bacteria in infectious sites completely owing to the currently severe drug resistance to existing antibiotics. Here, we report a simple and efficient one-step development of ultrasmall non-antibiotic nanoparticles (ICG-Ga NPs) containing clinically approved gallium (III) (Ga) and liver targeting indocyanine green (ICG) molecules to eradicate multi-drug resistant (MDR) bacteria thought the synergetic effect of photodynamic therapy and iron metabolism blocking. The ICG-Ga NPs induced photodynamic effect could destroy the bacterial membrane, further boost the endocytosis of Ga, then replace iron in bacteria cells to disrupt bacterial iron metabolism, and demonstrate the synergetic bacterial killing and biofilm disrupting effects. Read More

Front Microbiol 2021 8;12:642484. Epub 2021 Apr 8.

Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Hypervirulent (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. Read More

Korean J Gastroenterol 2021 04;77(4):190-193

Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

The rupture of a pyogenic liver abscess (PLA) with peritonitis is a rare occurrence but a surgical emergency with a high mortality rate in the case of gas-forming PLA. Rare cases of ruptured PLA that recovered completely with only medical treatment have been reported. This paper reports a case of a large PLA rupture with peritonitis. Read More

Microb Drug Resist 2021 Apr 20. Epub 2021 Apr 20.

Department of Medical Microbiology and Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Hypermucoviscous carbapenem-resistant (hmCRKp) is emerging globally and approaching the worst-case scenario in health care system. The main objective in this study was to determine the hypermucoviscous characteristics among the carbapenem-resistant (CRKp) isolated from a teaching hospital in Malaysia. The association of hypermucoviscous phenotype with the virulence traits and clinical presentations were also investigated. Read More

Endoscopy 2021 Apr 16. Epub 2021 Apr 16.

Division of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, New York, USA.

Abdom Radiol (NY) 2021 Apr 16. Epub 2021 Apr 16.

Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China.

Objective: Percutaneous catheter drainage (PCD) is the mainstream treatment for pyogenic liver abscess (PLA). However, in some patients with severe coagulopathy, there may increase the risk of bleeding complications related to PCD. Therefore, this study was aimed to evaluate the incidence of bleeding complications of PCD in PLA patients complicated with coagulopathy. Read More

Medicine (Baltimore) 2021 Apr;100(15):e25457

Department of Surgery, Soonchunhyang Uiversity Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan-si, Chungcheongnam-do, Republic of Korea.

Rationale: Spontaneous rupture of PLA (pyogenic liver abscess) is an extremely rare and life-threatening event. Ruptured PLA is very difficult to distinguish from malignant HCC (hepatocellular cancer) rupture or cholangiocarcinoma rupture on CT (computed tomography) scan.

Patient Concerns: We describe the case of a 71-year-old man with fever, right upper abdominal pain, nausea with intermittent vomiting, and general fatigue. Read More

Pediatr Infect Dis J 2021 May;40(5):e179-e184

Department of Medical Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Liver abscess (LA), a common problem in children in the tropics, is believed to be mostly pyogenic (PLA), sometimes amebic (ALA). We aimed to analyze the clinical profile, etiology, risk factors for complications, management and outcomes of LA in children.

Methods: The details of 81 children with LA managed in a tertiary set up over a period of 3 years were analyzed. Read More

Medeni Med J 2021 26;36(1):58-62. Epub 2021 Mar 26.

Bahçeşehir University School of Medicine, Department of Radiology, Istanbul, Turkey.

Lemierre's syndrome is an illness characterized by internal jugular vein thrombophlebitis related to infectious agents, primarily Fusobacterium necrophorum. These bacteria, residing in both the oropharynx and the gastrointestinal tract, may lead to pylephlebitis, a serious condition that could result in the development of hepatic abscesses. This manifestation of the disease is regarded as the abdominal variant of Lemierre's syndrome. Read More

J Am Coll Emerg Physicians Open 2021 Apr 1;2(2):e12412. Epub 2021 Apr 1.

Department of Emergency Medicine HCA Healthcare/USF Morsani College of Medicine GME/Brandon Regional Hospital Brandon Brandon Florida USA.

Pyogenic liver abscess (PLA) is a rarely encountered condition in the emergency department (ED) that necessitates a timely diagnosis by the emergency physician. An early ED diagnosis is challenging as the presenting symptoms of PLA are often variable and nonspecific. The rapid bedside diagnosis of PLA with point-of-care ultrasound (POCUS) performed by emergency physicians has not been investigated thoroughly. Read More

Int J Surg Case Rep 2021 Apr 5;81:105722. Epub 2021 Mar 5.

Instituto Português de Oncologia de Coimbra Francisco Gentil, Coimbra, Portugal. Electronic address:

Introduction And Importance: Hepatic abscess due to foreign body is rare. Diagnosis is difficult and drainage may not be enough. Hepatic resection may be indicated. Read More

Taiwan J Obstet Gynecol 2021 03;60(2):382-383

Department of Obstetrics and Gynecology, Saitama Medical University, Saitama, Japan.

Clin J Gastroenterol 2021 Apr 6;14(2):617-620. Epub 2021 Mar 6.

Department of Surgery, Hitachiomiya Saiseikai Hospital, Ibaraki, Japan.

Pyogenic liver abscesses generally occur secondary to spread from active infective lesions. We report a rare case of liver abscess in a patient without a clear source of infection. A 19-year-old man was diagnosed as having a liver abscess after investigations when he presented with chief complaints of fever and lethargy. Read More

Int J Surg Case Rep 2021 Mar 2;80:105499. Epub 2021 Jan 2.

Dept of General Surgery, Sapthagiri Institute of Medical Sciences & Research Centre, Karnataka, 570001, India.

Introduction: Pyogenic liver abscess is important cause of hospitalization and life threatening disease in low-middle income countries. Clinical spectrum of ruptured GFPLA can mimic hollow viscus perforation as it usually accompanied by pneumoperitoneum and peritonitis.

Case Presentation: We reported here a case with pneumoperitoneum caused by ruptured liver abscess in a 27-year-old man with a history of uncontrolled type II diabetes mellitus. Read More

BMC Infect Dis 2021 Feb 11;21(1):171. Epub 2021 Feb 11.

Division of Gastroenterology, Department of Internal Medicine, Jeonbuk National University Medical School and Research Institute of Clinical Medicine of Jeonbuk National University Hospital-Jeonbuk National University Medical School, 20 Geonjiro, Dukjingu, Jeonju, Jeonbuk, 54907, South Korea.

Background/aims: This study aimed to investigate the factors associated with prolonged hospital stay and in-hospital mortality in patients with pyogenic liver abscess.

Methods: We retrospectively reviewed data from patients with pyogenic liver abscess who were admitted between 2005 and 2018 at three tertiary hospitals in Jeonbuk province, South Korea. Prolonged hospital stay was defined as a duration of hospital admission of more than 21 days. Read More

Int J Clin Exp Pathol 2021 1;14(2):252-260. Epub 2021 Feb 1.

Department of Infectious Disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine 639 Zhizao Ju Road, Huangpu District, Shanghai 200011, China.

Pyogenic liver abscess is a life-threatening disease. It is urgent to review the clinical patterns, risk factors, and management of the disease in order to improve the outcome. We retrospectively analyzed 70 cases of pyogenic liver abscess diagnosed and treated at Shanghai Ninth People's Hospital over five years, including the clinical features, management, and outcome. Read More

J Community Hosp Intern Med Perspect 2021 Jan 26;11(1):42-45. Epub 2021 Jan 26.

Gastroenterology Department, St. Joseph's University Medical Center, Paterson, NJ, USA.

A pyogenic liver abscess (PLA) is the most frequently observed subtype of liver abscess in the western world. The disease has been subjected to a remarkable change. We aimed to investigate the recent trend in pyogenic liver abscess's epidemiology, clinical, microbiological, and risk factors features. Read More

Cureus 2020 Dec 23;12(12):e12236. Epub 2020 Dec 23.

General Medicine, Government Medical College and Hospital, Chandigarh, IND.

An elderly male with type 2 diabetes mellitus was admitted to the emergency ward with fever and pain over the right hypochondrium since one month. An abdominal ultrasound revealed an ill-defined hypoechoic lesion with multiple air foci measuring 8 x 6 x 4 cm within the left lobe of the liver implicating segments III b and IV. A contrast-enhanced computed tomography (CECT) scan of the abdomen showed a similar lesion with leakage of oral contrast into the dependent areas of the collection from a rent in the antero-inferior aspect of the first part of the duodenum. Read More