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Medicina (Kaunas) 2022 Jun 9;58(6). Epub 2022 Jun 9.

Department of Surgery, AHEPA General University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Acute cholecystitis, which is usually associated with gallstones is one of the most common surgical causes of emergency hospital admission and may be further complicated by mural necrosis, perforation and abscess formation. Perforation of the gallbladder is a relatively uncommon complication of acute cholecystitis (0.8-3. Read More

SAGE Open Med Case Rep 2022 10;10:2050313X221103357. Epub 2022 Jun 10.

Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Liver abscess following foreign body perforation of the gastrointestinal tract is uncommon. Preoperative diagnosis is challenging as the ingestion of foreign body most often goes unnoticed with non-specific presentation. We report a case of a 68-year-old male patient presenting with abdominal pain and anorexia. Read More

Sultan Qaboos Univ Med J 2022 May 26;22(2):257-261. Epub 2022 May 26.

Department of Medicine, Royal Hospital, Muscat, Oman.

Objectives: This study aimed to analyse the epidemiological, aetiological and clinical characteristics of pyogenic liver abscess (PLA) occurring in Oman. The intention was to obtain the information needed for the adequate liver abscess (LA) empirical treatment. LA can develop as a complication of hepatobiliary disease or other intraabdominal infections, but more recently, it is associated with primary and secondary liver malignancies and their treatment. Read More

Crit Rev Microbiol 2022 Jun 1:1-20. Epub 2022 Jun 1.

Center for Research on Infectious Diseases, School of Chemical and Biotechnology, SASTRA deemed University, Thanjavur, Tamil Nadu, India.

Treatment to common bacterial infections are becoming ineffective of late, owing to the emergence and dissemination of antibiotic resistance globally. and are the most notorious microorganisms and are among the critical priority pathogens listed by WHO in 2017. These pathogens are the predominant cause of sepsis, urinary tract infections (UTIs), pneumonia, meningitis and pyogenic liver abscess. Read More

Langenbecks Arch Surg 2022 May 30. Epub 2022 May 30.

Department of General-, Visceral-, and Transplantation Surgery, University Hospital Essen, Essen, Germany.

Purpose: Pyogenic liver abscess (PLA) is a collection of pus in the liver, often without a known direct cause. There is discord on the best diagnostic and therapeutic strategy. We aimed to examine these questions in our patient cohort. Read More

Dis Markers 2022 26;2022:7512736. Epub 2022 Apr 26.

Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China.

Background: Bacterial liver abscess (BLA) is a secondary infectious disease caused by hepatic parenchymal inflammation and bacterial necrosis. Studies have shown that diabetic patients with BLA have higher rates of related adverse events than patients without diabetes.

Aim: To explore the clinical characteristics of BLA complicated with diabetes and nondiabetes-related BLA. Read More

Indian J Crit Care Med 2022 Mar;26(3):381-383

Department of Radiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

The pyogenic liver abscess is usually polymicrobial and is seen as a complication of biliary disease or peritonitis. Over the past three decades, monomicrobial liver abscess caused by is being increasingly reported from South East Asian countries like Taiwan and Korea. It is a community-acquired infection caused by a distinct strain, hypervirulent , different from classical strain related to the healthcare-associated infections. Read More

J Belg Soc Radiol 2022 5;106(1):13. Epub 2022 Apr 5.

Military Hospital of Instruction Mohammed V, MA.

Spontaneous ruptured gas-forming pyogenic liver abscess (GFPLA) is a life-threatening infection that mimics perforation of hollow viscous and need to be accurately diagnosed by computed tomography, which in turn helps to decrease the operative time and improve patient's prognosis. Read More

WMJ 2022 Apr;121(1):E5-E9

Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

Introduction: Reports of extraintestinal manifestations of () infections are rare. The frequency of these infections comprises approximately 0.17% to 0. Read More

Cureus 2022 Mar 14;14(3):e23157. Epub 2022 Mar 14.

Gastroenterology, St. Joseph's Regional Medical Center, Paterson, USA.

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and extra-intestinal manifestations are common. Although common features of CD include fistulation and abscess formation, they typically manifest exclusively in the lower gastrointestinal (GI) tract and in patients who do not have adequate control over their disease. Pyogenic liver abscess is rare in the general population and is an unusual and extra-intestinal manifestation of CD. Read More

Cureus 2022 Mar 15;14(3):e23170. Epub 2022 Mar 15.

Department of Surgery, Hamdard Institute of Medical Sciences and Research, New Delhi, IND.

Background and objective Liver abscesses are one of the common surgical diseases to be treated as an emergency in any tertiary care hospital in India. The formation of abscesses in the liver is still a major problem and associated with significant morbidity in developing countries. We come across all types of liver abscesses, such as amoebic (most common), pyogenic, mixed, and occasionally fungal. Read More

Front Immunol 2022 21;13:843183. Epub 2022 Mar 21.

Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan.

is an important pathogen associated with nosocomial infection and has developed increasing resistance to antibiotics such as extended-spectrum β-lactams and carbapenem. In recent years, isolates have emerged as a major cause of global community-acquired infections such as pneumonia and pyogenic liver abscess. Although serotypes K1 and K2 have been identified as the predominant capsular types associated with invasive infections, no vaccine is commercially available, probably due to immunogenicity loss in the traditional depolymerization method to obtain capsule polysaccharide (CPS) for the preparation of conjugated vaccine. Read More

Cureus 2022 Feb 27;14(2):e22650. Epub 2022 Feb 27.

Department of Internal Medicine, Northeast Ohio Medical University, Cleveland, USA.

Gastric sleeve surgery is a frequently performed procedure. Although it is one of the safest bariatric procedures, it is like any other operation that carries significant risks and complications. Moreover, the hepatic abscess is an infrequent complication of laparoscopic gastric sleeve surgery, the infected late gastric leakage is a rare etiology of the hepatic abscess. Read More

Microbiol Spectr 2022 Apr 30;10(2):e0264621. Epub 2022 Mar 30.

Department of Bacteriology, Capital Institute of Pediatricsgrid.418633.b, Beijing, China.

While Klebsiella pneumoniae is a common cause of nosocomial and community-acquired infections, including pneumonia and pyogenic liver abscess, little is known about the population structure of this bacterium. In this study, we investigated the prevalence and molecular characteristics of K. pneumoniae isolates from carriers, pyogenic liver abscess patients, and pneumonia patients, and genomic and phenotypic assays were used to determine the differences among the isolates. Read More

Cureus 2022 Feb 22;14(2):e22501. Epub 2022 Feb 22.

Department of Infectious Diseases, East Tennessee State University Quillen College of Medicine, Johnson City, USA.

() is a commensal organism of the gastrointestinal tract. It rarely causes hepatobiliary infections; however, in the presence of underlying inflammation, immunosuppression, or malignancy, it can cause hepatobiliary infection via an ascending route. Herein, we report a case of pyogenic liver abscess secondary to associated with cholangiocarcinoma, which was treated with ceftriaxone and metronidazole. Read More

J Infect Public Health 2022 Apr 15;15(4):425-432. Epub 2022 Mar 15.

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Gram-negative bacteria such as Klebsiella pneumoniae and Escherichia coli are the most common cause of pyogenic liver abscess (PLA). We investigated whether the use of anaerobic-covering antibiotics is essential for the treatment of pyogenic liver abscess.

Methods: We analyzed the Health Insurance Review and Assessment Service data in Korea between 2007 and 2017. Read More

Infection 2022 Mar 22. Epub 2022 Mar 22.

Service de Médecine Interne, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Université de Paris, 100 Boulevard du Général Leclerc, 92110, Clichy, France.

Purpose: Pyogenic liver abscess (PLA) is a severe disease, which unfavourable evolution remains frequent. Our objective was to assess predictive factors of unfavourable outcome in patients with PLA.

Methods: We conducted a retrospective study in a French tertiary care centre. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221084513

Mountain View Medical Center, Las Vegas, NV, USA.

The 2019 coronavirus disease (COVID-19) can present with a wide variety of clinical manifestations, including a hypercoagulable state leading to both arterial and venous thrombosis. Portal vein thrombosis (PVT) in the setting of COVID-19 has rarely been reported in the medical literature. Pylephlebitis with concomitant liver abscess is a rare complication of intra-abdominal infection. Read More

Virus Res 2022 Jun 18;314:198750. Epub 2022 Mar 18.

College of Veterinary Medicine, Nanjing Agricultural University, No.1 Weigang, Xuanwu District Nanjing City, 210095, China; Key Lab of Animal Bacteriology, Ministry of Agriculture, No.1 Weigang, Xuanwu District Nanjing City, 210095, China; OIE Reference Lab for Swine Streptococcosis, No.1 Weigang, Xuanwu District Nanjing City, 210095, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, No.1 Weigang, Xuanwu District Nanjing City, 210095, China. Electronic address:

In recent years, Klebsiella pneumoniae has caused an increase in the number of serious infections associated with pneumonia, septicemia, urinary tract infections, and pyogenic liver abscess. In this study, a phage P929, isolated from hospital sewage in Jiangsu, could specifically infect K. pneumoniae KL19 capsular type by forming plaques with a translucent halo that expanded over time. Read More

BMJ Case Rep 2022 Mar 18;15(3). Epub 2022 Mar 18.

Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, Kentucky, USA.

Hepatic abscesses can rarely cause pericardial disease by erosion into the pericardial space and present with haemodynamic instability due cardiac tamponade. While rare, these dramatic presentations are more often due to amoebic abscesses than bacterial abscesses. Importantly, a cause must be found for any cryptogenic hepatic abscess regardless of presentation, as there is a high association with underlying malignancy. Read More

Cureus 2022 Jan 27;14(1):e21672. Epub 2022 Jan 27.

Department of Medicine, Hamad Medical Corporation, Doha, QAT.

Acute abdominal pain with free air under the diaphragm visible on chest/abdomen X-ray (pneumoperitoneum) is a medical emergency. Most of such cases of pneumoperitoneum are attributable to perforated hollow viscus; however, other possibilities like rupture of liver abscess (by a gas-forming organism) also need to be considered. Further imaging like a CT scan might help in the diagnosis and would also obviate the need for laparotomy in some of such cases. Read More

Rev Soc Bras Med Trop 2022;55:e0635. Epub 2022 Feb 25.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Infectious Diseases, Shanghai, China.

Internist (Berl) 2022 Apr 3;63(4):349-366. Epub 2022 Mar 3.

Klinik für Innere Medizin IV, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Ascending cholangitis and pyogenic liver abscesses are acute febrile bacterial hepatobiliary diseases. Nowadays they frequently occur in patients with structural changes of the biliary system and are usually treated by a combination of interventional drainage procedures and antimicrobial therapy. While Gram-negative Enterobacterales were identified as major causes in the past, biliary tract interventions and antibiotic exposure have contributed to an increase in enterococcal species and extended spectrum beta-lactamase (ESBL)-producing Enterobacterales. Read More

Cureus 2022 Jan 21;14(1):e21477. Epub 2022 Jan 21.

Interventional Radiology, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.

Objective: To assess if hepatic abscess incidence in a Midwest cohort was higher in rural areas compared to metropolitan areas in relation to water infrastructure.

Materials And Methods: All cases of hepatic abscesses from Jan 1, 2016 through Dec 31, 2019 at Avera McKennan Hospital in Sioux Falls, South Dakota (SD), were retrospectively collected. Chart review was completed for each case for risk factor analysis. Read More

J Clin Med 2022 Feb 19;11(4). Epub 2022 Feb 19.

Department of Internal Medicine, Kangnam Sacred Heart Hospital of Hallym University Medical Center, 1, Singil-ro, Seoul 07441, Korea.

The emergence of multidrug-resistant organisms (MDROs) is a growing problem worldwide. However, little is known about the incidence, clinical features and outcomes of pyogenic liver abscesses (PLAs) caused by MDROs. A retrospective study of 833 patients with PLA admitted from 2008 to 2017 was performed. Read More

Ann Med Surg (Lond) 2022 Mar 31;75:103308. Epub 2022 Jan 31.

Department of Surgery, Gaston Berger University, Saint-Louis, Senegal.

Background: Liver abscess is a common cause of intra-abdominal infection and its treatment depends on the presentation. Laparoscopy, in addition to its classic benefits, has particular advantages in the management of liver abscess but its role is not well defined and studies done in that field are heterogenous. The objective of this systematic review is to evaluate the efficacy of laparoscopic surgery in the management of liver abscess. Read More

J Infect Dev Ctries 2022 01 31;16(1):222-225. Epub 2022 Jan 31.

Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Clostridium perfringens causes pyogenic liver abscesses, which are rare but rapidly fatal infections. These abscesses often occur in patients with immunodeficiency due to malignancy, liver cirrhosis, diabetes mellitus, or organ transplantation. The identification of gram-positive bacilli in septicemia, the presence of gas-forming liver damage and intravascular hemolysis are manifestations of Clostridium perfringens infection. Read More

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(2):162-171

Department of Internal Medicine, Tohokukosai Hospital.

A 76-year-old Japanese man was admitted to our hospital with chills and fever. Computed tomography revealed a 10-cm cystic tumor with peripheral ring enhancement in the left lobe of the liver and several small low-density areas with early peripheral enhancement in both lobes. The large liver mass was diagnosed as a pyogenic abscess and treated with antibiotics. Read More

IDCases 2022 1;27:e01441. Epub 2022 Feb 1.

Division of Infectious Diseases, Ann & Robert H Lurie Children's Hospital, USA.

Amebic liver abscess (ALA) is a common condition in the developing world but is rare in the United States without a clear exposure risk. It is even less common to develop in an infant. The diagnosis of ALA can be logistically difficult and often requires invasive procedures and testing with slow turnaround times. Read More

BMC Gastroenterol 2022 Feb 7;22(1):52. Epub 2022 Feb 7.

Gastroenterology Division, Department of Medicine, Icahn School of Medicine at Elmhurst Hospital, Elmhurst, NY, 11373, USA.

Background: Juxta-papillary duodenal diverticulum (JPDD) has been associated with obstructive jaundice and ascending cholangitis. Potential mechanisms include periampullary colonization of pathogenic bacteria and mechanical obstruction. However, the relation of JPDD with pyogenic liver abscess (PLA) has not been reported. Read More