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Arch Craniofac Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Plastic and Reconstructive Surgery, Inje University Haeundae Paik Hospital, Busan, Korea.

Orocutaneous fistulas, or cutaneous sinuses of odontogenic origin, are uncommon but often misdiagnosed as skin lesions unrelated to dental origin by physicians. Accurate diagnosis and use of correct investigative modalities are important because orocutaneous fistulas are easily confused for skin or bone tumors, osteomyelitis, infected cysts, salivary gland fistulas, and other pathologies. The aim of this study is to present our experience with a patient with orocutaneous fistulas of odontogenic origin presenting as recurrent pyogenic granuloma of the cheek, and to discuss their successful treatment. Read More

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

The University of Texas McGovern Medical School at Houston, Houston, Texas.

Fibro-osseous pseudotumor of the toe is a benign soft tissue tumor that is predominant in the young adult population. Although the etiology is unknown, a history of trauma has been reported to precede tumor development. The differential diagnosis includes myositis ossificans, extraskeletal osteosarcoma, and pyogenic granuloma. Read More

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Aims: To systematically describe the clinical and histopathological features of a case series of conjunctival carcinomatous lesions underlying as-and also masquerading-pyogenic granuloma.

Methods: Nine cases of conjunctival carcinomatous lesions underlying a pyogenic granuloma (which were clinically predominant) were retrospectively identified. Patients' records were analysed for demographic data, clinical appearance and the postoperative course. Read More

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

The Ohio State University, 305 W. 12 Ave, Columbus, OH, 43210, USA.

Erythematous lesions of the oral mucosa are common and can reflect a variety of conditions, ranging from benign reactive or immunologically-mediated disorders to malignant disease. Together with vascular abnormalities, which can vary from reddish to bluish-purple in color, the differential diagnosis for erythematous oral mucosal change is quite diverse. This review focuses on salient clinical features and histopathologic findings of selected conditions which clinically present as red or vascular-like oral mucosal alterations, including oral vascular malformations and neoplasms, pyogenic granuloma, localized juvenile spongiotic gingival hyperplasia, denture stomatitis, benign migratory glossitis (geographic tongue), orofacial granulomatosis, granulomatosis with polyangiitis (Wegener granulomatosis), megaloblastic anemia, and erythroplakia. Read More

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK.

Lesions of the gingivae are amongst the commonest lesions seen in patients and the vast majority are reactive hyperplasias, related to a number of chronic irritant stimuli. However, there are a number of entities that have a predilection for the gingivae, which are much less common in other parts of the oral cavity. The purpose of this paper is to discuss the clinical and histological differential diagnoses when presented with a lump on the gingivae, including the approach to diagnosis and diagnostic pitfalls. Read More

Gastrointest Endosc 2019 Jan 21. Epub 2019 Jan 21.

Division of Gastroenterology and Hepatology, MedStar Georgetown University Hospital, Washington, DC.

J Oral Pathol Med 2019 Jan 23. Epub 2019 Jan 23.

Brazilian Centre for Evidence-Based Research, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.

Objective: To assess the prevalence of oral mucosal disorders during pregnancy.

Methods: Observational studies were selected by two reviewers in a two-phase process. Search strategies were applied at CINAHL, LILACS, LIVIVO, PubMed, Scopus, Web of Science, Google Scholar, OpenGrey, and ProQuest. Read More

J Cutan Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.

A 52-year-old man presented with a rapidly growing red tumor on the central neckline. It had appeared over a congenital flat and pinkish vascular lesion that involved the shoulder and the upper anterior area of his chest. Intermingled with the pinkish stain, there were also some blue nodules several millimeters in diameter. Read More

G Ital Dermatol Venereol 2019 Feb;154(1):95-96

Unit of Dermatology, Ca' Granda Foundation and Institute for Research and Care, Maggiore Polyclinic Hospital, Milan, Italy.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e409-e410. Epub 2018 Dec 19.

Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.

J Dermatol 2018 Dec 28. Epub 2018 Dec 28.

Pediatric Dermatology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Pyogenic granuloma is a benign acquired vascular tumor that affects the skin and mucous membranes, occurring more often in children and young adults. Treatment is often required due to the associated risk of ulceration and bleeding. There are several publications reporting the use of beta-blockers for the treatment of pyogenic granuloma. Read More

In Vivo 2019 Jan-Feb;33(1):251-254

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Read More

J Bone Jt Infect 2018 24;3(5):255-257. Epub 2018 Nov 24.

Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, Nantes, France.

After rifampin and levofloxacin treatment for a bone infection, a pyogenic granuloma due to a newly described species, developed on the tibia former external fixator. This rifampin resistant bacterium, selected during treatment, harbored a mutation in the gene. This case illustrates the possible selection of resistant mutant most likely due to the bacterial burden and therefore the importance of adequate bone infection treatment. Read More

J Am Dent Assoc 2019 Feb 7;150(2):147-153.e2. Epub 2018 Dec 7.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion of unknown cause. The purpose of this study is to present a series of LJSGH cases and compare the findings with the literature.

Methods: After obtaining institutional review board approval, cases of biopsy-proven LJSGH from 2008 through 2018 were retrieved from the University of Pittsburgh Oral Pathology Biopsy Service archives and reviewed. Read More

Am J Otolaryngol 2018 Oct 29. Epub 2018 Oct 29.

Head and Neck Institute, Cleveland Clinic, Cleveland, OH, USA.

Pyogenic granuloma (PG) may involve gingival mucosa (granuloma gravidarum) in pregnancy but rarely involves the airway. This case report is perhaps the only reported presentation of PG in the larynx causing hemoptysis at a late stage of pregnancy. On laryngoscopic exam, a vascular, right false vocal fold neoplasm was identified with pathological characteristics consistent with PG. Read More

J Exp Ther Oncol 2018 Nov;12(4):291-294

MBBS student, Hind Institute of Medical Sciences, Lucknow, U.P, India.

Objective: A telangiectatic granuloma is a localized reactive lesion associated with prolonged irritation to the soft tissues. It may be misdiagnosed as a vascular malformation, hemangiomas, angiosarcomas, etc; as clinical presentation of the lesions resembles each other. Here, we present a case of asymptomatic swelling in the maxilla of a 17-year old female patient. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. In this continuing medical education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities. Read More

J Fr Ophtalmol 2018 Dec 13;41(10):991-992. Epub 2018 Nov 13.

Departement A of ophtalmology, Mohammed V university, Rabat, Maroc.

J Hand Surg Asian Pac Vol 2018 Dec;23(4):577-580

1 Department of Orthopaedics, Miri General Hospital, Miri, Malaysia.

Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular lesion of the skin or mucous membrane with rapid growth or repetitive trauma. Rarely seen in adult, its management varies and surgical intervention is usually common. We report a case of pyogenic granuloma of the right index finger in a 46-year-old gentleman who presented with painless swelling of the right index finger after a trivial injury. Read More

Ann Dermatol Venereol 2018 Dec 8;145(12):806-808. Epub 2018 Nov 8.

Service de dermatologie, CHRU de Lille, université de Lille, hôpital Claude-Huriez, rue Michel-Polonowski, 59000 Lille, France.

Indian J Dent Res 2018 Sep-Oct;29(5):678-682

Department of Periodontology, Government Dental College and Hospital, Mumbai, Maharashtra, India.

The peripheral giant cell granuloma (PGCG) is a benign oral lesion occurring on the gingiva and alveolar ridge. It is the most common oral lesion and occurs at an average age of 30 years. The upsurge in the levels of estrogen and progesterone in pregnancy leads to a plethora of changes in various parts of human body, including the oral cavity. Read More

Ophthalmic Plast Reconstr Surg 2018 Nov 5. Epub 2018 Nov 5.

Department of Ophthalmology and Visual Sciences, W. K Kellogg Eye Center, Ann Arbor, Michigan U.S.A.

Purpose: To describe the use of cryopreserved ultra-thick human amniotic membrane for management of anophthalmic socket contracture.

Methods: A chart review was performed to identify patients undergoing fornix reconstruction with cryopreserved ultra-thick human amniotic membrane for management of anophthalmic socket contracture. Patient demographics, disease etiology, and data regarding postoperative prosthesis fit and complications were collected. Read More

Case Rep Dent 2018 14;2018:5180385. Epub 2018 Oct 14.

School of Dentistry, University Center of Patos de Minas (UNIPAM), Patos de Minas, MG, Brazil.

Oral surgery to remove pyogenic granuloma in a high-risk patient is reported. A 47-year-old man with gastroesophageal reflux disease, diabetes mellitus II, dyslipidemia, and chronic coronary insufficiency (myocardial infarction within 2 years) with episodes of unstable angina was submitted to an excisional biopsy of hemorrhagic lesion in the lingual right mandibular gingiva. During dental treatment, the arterial blood pressure, oxygen saturation, heart rate, and electrocardiogram were monitored. Read More

J Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, National Cancer Center Hospital East, Chiba, Japan.

Photochem Photobiol Sci 2019 Feb;18(2):343-348

Department of Dermatology, Medical University of Vienna, Austria.

Background And Objective: Pyogenic granuloma is a common benign vascular lesion of the skin and mucosa prone to ulceration and bleeding. Current therapeutic approaches include surgical excision, removal by means of electro caustic therapy, cryotherapy, and ablation with CO2 or vascular lasers. The purpose of this study was to investigate the efficacy of a 532 nm potassium-titanyl-phosphate laser (KTP-laser) for the treatment of pyogenic granulomas in terms of efficacy, advantages in clinical outcome, technique and associated side effects. Read More

Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39

Institut Universitaire du Cancer Toulouse - Oncopole, 1 avenue Irène Joliot-Curie, 31059, TOULOUSE Cedex 9, France.

Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25-85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. Read More

Int J Dermatol 2018 Oct 21. Epub 2018 Oct 21.

Dermatology Department, University of Patras, Patras, Greece.

Pyogenic granuloma is a benign vascular proliferation of the skin and mucous membranes, whose pathogenesis is not fully understood. Despite its benign nature, it can have a significant negative impact on patients' quality of life, and therefore appropriate therapy is needed. Over the years, a lot of therapeutic modalities have been used in order to successfully treat this condition. Read More

G Ital Dermatol Venereol 2018 Oct 11. Epub 2018 Oct 11.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Pediatr Dermatol 2019 Jan 15;36(1):e41-e43. Epub 2018 Oct 15.

Dermatopathology Division, Department of Pathology and Laboratory Medicine, Sylvester Comprehensive Cancer Center and Miller School of Medicine, University of Miami, Miami, Florida, USA.

Disseminated congenital pyogenic granuloma (DCPG) is an uncommon condition. Individual lesions of DCPG share clinical and histologic similarities with infantile hemangioma (IH); endothelial glucose transporter 1 (GLUT-1), which is highly expressed in IH but generally not in pyogenic granulomas (PG), is an important diagnostic tool. Treatment for DCPG remains difficult. Read More

Dig Liver Dis 2018 Sep 27. Epub 2018 Sep 27.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Ann Dermatol Venereol 2018 Oct 9. Epub 2018 Oct 9.

Service de dermatologie, CHR Metz-Thionville, 57000 Metz, France.

Background: Cutaneous metastases (CM) on the extremities are rare complication of cancer with poor prognosis. In general, lesions simulate an infection. Herein, we report two new cases with atypical presentation. Read More

Ann Med Surg (Lond) 2018 Nov 4;35:158-162. Epub 2018 Oct 4.

Plastic and Reconstructive Surgery, Surgery Department, King Fahad National Guard Hospital, King Abdulaziz Medical City (KAMC), Saudi Arabia.

Background: Fibro-osseous pseudotumor (FOPD) of the digit is a rare benign lesion of subcutaneous tissue characterized by fibroblastic proliferation and osteoid formation. Herein, we present a case of massive FOPD lesion in the base of ring finger with extensive involvement of the neurovascular bundles with challenging surgical approach.

Case Description: A 27-year old female patient, presented with 7-months history of a progressively enlarging mass on her left hand. Read More

Br J Dermatol 2018 Oct 9. Epub 2018 Oct 9.

Section of Dermatology, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.

J Am Coll Clin Wound Spec 2016 5;8(1-3):39-41. Epub 2017 Sep 5.

Kirikkale University Faculty of Medicine, Department of Dermatology and Venerology, No:14 Yenisehir District, Tahsin Duru Avenue, Yahsihan, Kirikkale, Turkey.

Pyogenic granuloma (PG) is a common, acquired, benign vascular reactive proliferation. This article presents the unique and successful pulsed dye laser treatment of a labial PG on a 60-year-old patient. Read More

Indian Dermatol Online J 2018 Sep-Oct;9(5):293-298

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.

Paronychia is a painful inflammatory disorder of the nail fold. Periungual pyogenic granuloma - a benign vascular tumor of the capillaries - can develop as a complication of paronychia. We report both, paronychia and periungual pyogenic granuloma, as possible adverse events during systemic drug-therapy. Read More

G Ital Dermatol Venereol 2018 Sep 20. Epub 2018 Sep 20.

San Gallicano Dermatological Institute IRCCS, Rome, Italy -

Arq Bras Oftalmol 2018 Sep-Oct;81(5):366-370

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To evaluate the outcomes of dermis-fat graft procedure for orbital volume replacement in anophthalmic socket.

Methods: A retrospective chart review was performed studying all dermis-fat graft surgeries done at King Khlaed Eye Specialist Hospital in the last 10-year period. Sixty-two anophthalmic socket carriers underwent dermis-fat graft during the study period. Read More

Dermatol Clin 2018 Oct 31;36(4):389-395. Epub 2018 Jul 31.

Dermatology Unit, University of Campania Luigi Vanvitelli, Via Pansini 5, Naples 80131, Italy.

Cutaneous vascular lesions (VLs) represent a very common reason for dermatologic consultation for patients. In most cases, VLs are benign and self-limiting. However, because they often mimic malignant skin tumors, their correct and prompt identification is very important in daily practice. Read More

Open Dent J 2018 29;12:560-566. Epub 2018 Aug 29.

Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: The isolation of stem cells from pathologically damaged dental tissues has been examined only by a few studies. The purpose of this study was to evaluate the possibility of isolation of stem cells from pyogenic granuloma.

Methods: Pyogenic granuloma tissues were enzymatically digested and the resulting single cells were cultured. Read More

Orv Hetil 2018 Sep;159(37):1516-1524

Fogorvostudományi Kar, Szájsebészeti Tanszék, Szegedi Tudományegyetem Szeged.

Introduction: In a clinicopathological retrospective epidemiological study we investigated benign tumors and tumor-like lesions located in the orofacial region, diagnosed at the Universiy of Szeged, Department of Oral Medicine.

Method: During a 54-year period (1960-2014), 14 661 biopsies were taken. The included subjects were 7491 patients diagnosed with benign tumors and tumor-like lesions. Read More

J Dermatol 2018 Sep;45(9):1145-1146

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

J Orthop Case Rep 2018 Mar-Apr;8(2):47-50

Department of Orthopaedics, St. John's Medical College, Bengaluru, Karnataka, India.

Introduction: The swellings of foot are common but the lesions of metatarsals are rare. The purpose is to highlight these four cases which had almost common presentations but had different etiologies.

Case Report: A series of four cases all of which had similar presentation, but different etiologies. Read More

Case Rep Dent 2018 12;2018:2474706. Epub 2018 Aug 12.

Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome, Rome, Italy.

The aim is to discuss four cases of gingival reactive hyperplastic lesions in patients with a history of excision of oral neoplastic lesions and rehabilitation by a free revascularized flap of the iliac crest. One female and 3 male patients were referred due to the presence of exophytic lesions at the rehabilitated sites. The clinical examination revealed that the poor oral hygiene was the common trigger factor in all the cases, in addition to trauma from the upper left second molar in the first case, pericoronitis related to a partially erupted lower right third molar in the third case, and poor stability of an upper removable partial denture in the fourth case. Read More

Dent Med Probl 2018 Jan-Mar;55(1):83-86

Department of Periodontology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Mangalore, India.

Most of the reactive lesions in the oral cavity arise from gingiva. Fibroma, focal fibrous hyperplasia, pyogenic granuloma, and peripheral ossifying fibroma are the commonly encountered lesions of gingiva. Peripheral ossifying fibroma (POF) frequently arises from the peripheral tissues like gingiva. Read More

J Indian Soc Periodontol 2018 Jul-Aug;22(4):360-364

Department of Periodontology, The Oxford Dental College, Bengaluru, Karnataka, India.

Pyogenic granuloma (PG) is an inflammatory hyperplastic lesion of the oral cavity. The most common etiological factors for PG are low-grade local irritation, traumatic injury, or hormonal factors. Clinically, it appears to be smooth or lobulated exophytic lesion. Read More

Clin J Gastroenterol 2019 Feb 9;12(1):34-37. Epub 2018 Aug 9.

Pediatric Gastroenterology Unit, Oporto Hospital Center, Porto, Portugal.

We describe the case of a previously healthy 8-year-old girl presenting with a 1-year history of iron deficiency anemia. There was no report of hematemesis, abdominal pain or melena. Laboratory work-up excluded iron malabsorption as the underlying cause. Read More

BMJ Case Rep 2018 Aug 9;2018. Epub 2018 Aug 9.

Department of Conservative Dentistry and Endodontics, King George's Medical University, Lucknow, Uttar Pradesh, India.

Pyogenic granuloma is a 'reactive lesion' in the oral cavity caused due to hormonal imbalance or poor oral hygiene. There are different methods to excise this lesion but most successful is treatment with lasers. Currently, there are different lasers available commercially and are used by clinicians to excise this lesion. Read More

J Craniofac Surg 2018 Nov;29(8):2160-2163

Department of Biomedical, Odontostomatological, Sciences and Morphological and Functional Images, School of Dentistry, University of Messina, Messina.

The use of laser in oral surgery and periodontology is a matter of debate, mainly because of the lack of consensual therapeutic protocols. The aim of this study was to evaluate the surgical advantages of diode laser versus traditional surgery with a cold blade for the surgical excision of pyogenic granuloma (PG). Twenty-one patients (10 males, 11 females, aged 19-66 years; mean age: 46. Read More