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Dig Liver Dis 2020 Jul 7. Epub 2020 Jul 7.

Department of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure 737-0023, Japan.

J Craniofac Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea.

As the authors recently experienced a patient with pyogenic granuloma arising from the hard palate, they tried to review all the previously reported literatures with the emphasis on its clinical characteristics that can help the accurate diagnosis of this unusual lesion. Based on our experience and literatures review, clinicians should keep in mind that pyogenic granuloma should be taken into consideration in the differential diagnosis of the hard palatal mass despite its rarity. Although histopathological examination of the mass is the only way to arrive at a definitive diagnosis, the knowledge of the gross appearances of pyogenic granuloma with clinical features may be helpful for differential diagnosis. Read More

Am J Dermatopathol 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, NH.

Cutaneous metastases by solid malignancies often signify advanced disease and portend severely limited survival. Appropriate diagnosis of these lesions is particularly hampered when they closely resemble primary cutaneous tumors. In this article, we present two diagnostically challenging cases of metastatic lesions to the scalp bearing striking histologic resemblance to primary cutaneous neoplasms. Read More

J Oral Maxillofac Surg 2020 Jun 10. Epub 2020 Jun 10.

Associate Professor, Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA.

Purpose: The aim of the present study was to increase awareness of an underreported surgical complication by presenting the relevant findings of cases of herniated oroantral sinonasal polyp (OASNP) identified from our biopsy service and from previously reported cases.

Materials And Methods: The present study was a retrospective descriptive case series with a review of the reported data. Cases of OASNP were identified from our biopsy service, and the clinical, radiographic, surgical, and demographic information was retrieved. Read More

Laryngoscope 2020 Jul 7. Epub 2020 Jul 7.

Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, Ostrava, Czech Republic.

J Pediatr 2020 Jul 2. Epub 2020 Jul 2.

Division of Vascular and Interventional Radiology, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

Objective: To describe the clinical, radiological and histopathological features of "congenital disseminated pyogenic granuloma" (CDPG) involving various organs with high morbidity related to cerebral hemorrhagic involvement.

Study Design: We searched the database of the Vascular Anomalies Center at Boston Children's Hospital from 1999 to 2019 for patients diagnosed as having multiple vascular lesions, visceral vascular tumors, congenital hemangiomatosis, multiple pyogenic granulomas or multiple vascular lesions without a definite diagnosis. A retrospective review of the medical records, photographs, histopathological and imaging studies was performed. Read More

Dermatol Ther 2020 Jul 4:e13966. Epub 2020 Jul 4.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

A 65-year-old women presented with sharply demarcated macules and small nodules on her face and neck for 2.5 years. They first appeared on her left face and gradually spread to her whole face and neck. Read More

Gen Dent 2020 Jul-Aug;68(4):61-63

Down syndrome (DS), a genetic disorder caused by chromosome 21 trisomy, is characterized by intellectual disability, congenital malformations, craniofacial alterations, and dentofacial anomalies. Although some oral lesions have been reported in patients with DS, this is the first reported case of a pyogenic granuloma affecting the tongue of a patient with DS. A 20-year-old man presented with a well-demarcated nodular lesion on the right lateral border of the tongue. Read More

Gen Dent 2020 Jul-Aug;68(4):28-31

The conventional method of managing intraoral soft tissue overgrowth involves surgical excision using a scalpel under local anesthesia. These procedures are often associated with excessive bleeding that leads to complications. Now, minimally invasive methods such as laser excision are available for the management of intraoral soft tissue lesions. Read More

Breast J 2020 Jun 24. Epub 2020 Jun 24.

Department of Surgery, Dankook University College of Medicine, Cheonan, Republic of Korea.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):148-151. Epub 2020 May 8.

Department of Oral Pathology, MM College of Dental Sciences and Research, Mullana (Deemed to be University), Ambala, Haryana, India.

The presence of eosinophilic Toto bodies in oral lesions could be found in a variety of situations and sometime may present a challenge to the pathologist. We present three case reports where the oral biopsy was taken from the gingival region of a 30-year-old female, a 32-year-old male patient and another from the buccal mucosa of a 67-year-old male patient. Histopathologically, the three cases were finally diagnosed as pyogenic granuloma and moderately differentiated squamous cell carcinoma with the presence of clusters of Toto bodies in the upper spinous layer of stratified squamous epithelium. Read More

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):76-80. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Bareilly International University, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Context: Focal fibrous hyperplasia, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, giant cell fibroma and focal reactive overgrowth (FROGs) are one of the foremost numerous benign soft-tissue growths in the oral cavity. Chronic irritation or trauma is with identified as the causative aspect. It may develop up to few centimeters in diameter, pedunculated or sessile and may arise on the gingiva or buccal mucosa. Read More

Am J Surg Pathol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.

Intravascular lobular capillary hemangioma (ILCH), or intravascular pyogenic granuloma, is relatively rare and likely underrecognized. We reviewed all ILCH cases from our institution confirmed pathologically from 2006 to 2019. Immunostains for smooth muscle actin and Wilms tumor 1 were performed on all cases and prior immunohistochemical stains were reviewed. Read More

Dermatol Ther 2020 May 29:e13710. Epub 2020 May 29.

Dermatology Unit, Department of Medical, Surgical and Neurological Science, S. Maria Alle Scotte Hospital, University of Siena, Siena, Italy.

Respir Med Case Rep 2020 11;30:101073. Epub 2020 May 11.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Background: Lobular capillary hemangiomas (LCH) are acquired benign vascular lesions of the skin and mucous membranes mostly affecting the head and neck region. Involvement of the nasal cavity is extremely rare and can manifest as epistaxis and nasal obstruction.

Case Series: In this case series, we present five cases of intranasal LCH. Read More

Case Rep Med 2020 9;2020:2870715. Epub 2020 May 9.

College of Dental Medicine, University of Sharjah, Sharjah, UAE.

The peripheral ameloblastoma (PA), also known as extraosseous ameloblastoma, is a rare soft tissue tumor of odontogenic origin, accounting for 1-5% of all ameloblastoma. In some cases, saucerization of underlying bone is the only radiological evidence of this lesion, and PA has identical histological characteristics of intraosseous ameloblastoma. However, it is slow growing, less aggressive, and less invasive in nature. Read More

Spec Care Dentist 2020 May 22;40(3):285-290. Epub 2020 May 22.

Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Tokyo, Japan.

Aim: Tongue bites frequently occur during seizures in epilepsy patients. We report two cases of cognitively impaired Lennox-Gastaut syndrome patients with reactive lesions on the tongues.

Case Presentations: Case 1 was a 30-year-old man whose chief complaint was mouth pain. Read More

J Clin Neurosci 2020 May 14. Epub 2020 May 14.

Service de Radiologie, Institut Mohamed Kassab d'orthopédie, Ksar Said, Tunisia.

Brucellar spondylodiscitis (BS) is the most common form of musculoskeletal brucellosis. The isolation of Brucella spp from blood, other body fluids or tissue cultures is the gold standard for definitive diagnosis of BS. BS shows a large histopathological spectrum of lesions with non-specific and granulomatous forms, and its histopathological features are not widely reported. Read More

Head Neck Pathol 2020 May 7. Epub 2020 May 7.

Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.

A 47-year-old man presented to the otolaryngology service with complaint of 6 months of intermittent globus sensation. He reported constant throat clearing and subjective lowering of his voice. Flexible nasolaryngoscopy revealed a large pedunculated mass originating from the left vocal process of the arytenoid, lying superior to the vocal fold. Read More

Clin Implant Dent Relat Res 2020 Jun 7;22(3):366-372. Epub 2020 May 7.

Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa, Spain.

Background: Peri-implantitis is the inflammatory process, which most commonly affects the therapy with dental implants. However, there are other reactive and neoplastic entities, mainly benign but also malignant, which also take place in the peri-implant mucosa. There is little information about the histopathological analysis of these peri-implant inflammatory diseases. Read More

Eplasty 2020 22;20:ic2. Epub 2020 Feb 22.

Department of Oral and Maxillofacial Surgery and Plastic Surgery.

Clin Gastroenterol Hepatol 2020 Apr 30. Epub 2020 Apr 30.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico.

ACG Case Rep J 2019 Nov 26;6(11):e00250. Epub 2019 Nov 26.

Department of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD.

Diagn Pathol 2020 Mar 23;15(1):26. Epub 2020 Mar 23.

Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Insulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types, and its expression is often associated with poor prognosis. IGF2BP3 expression has not been fully settled in vascular lesions.

Methods: We evaluated the expression of IGF2BP3 in malignant (angiosarcoma and epithelioid hemangioendothelioma [EHE]) and benign (hemangioma, granulation tissue cappilaries, and pyogenic granuloma) vascular lesions using immunohistochemistry. Read More

JAAD Case Rep 2020 Apr 1;6(4):378-380. Epub 2020 Apr 1.

Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

J Dent Sci 2020 Mar 17;15(1):92-95. Epub 2019 Oct 17.

Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Background/purpose: Oral metastatic carcinomas are rarely found in oral soft tissues. This study reported the clinicopathological features of 13 intraoral soft tissue metastatic carcinomas.

Materials And Methods: A total of 13 intraoral soft tissue metastatic carcinomas were included in this study. Read More

Acta Neurochir (Wien) 2020 Apr 2. Epub 2020 Apr 2.

Department of Neurosurgery, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark.

A lobular capillary hemangioma, previously known as a pyogenic granuloma, is a benign vascular lesion of the skin or mucous membrane. We report a case of capillary hemangioma of lobular subtype in the calvarium of a 28-year-old pregnant woman which presented as a sore and rapidly growing bulge over the left fronto-parietal region. Magnetic resonance imaging of the brain and skull showed an expansive tumor with brain displacement, skull erosion, and scalp infiltration. Read More

Ann Diagn Pathol 2020 Mar 13;46:151506. Epub 2020 Mar 13.

Department of Radiodiagnosis, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India.

The International Society for the Study of Vascular Anomalies (ISSVA) devised a multidisciplinary etiopathogenesis based approach to classify benign vascular anomalies into tumors and malformations. This classification scheme has major therapeutic and prognostic implications as treatment modalities differ for both the categories. Inappropriate usage of the term "hemangioma" for etiopathogenetically distinct entities is commonly seen in clinical practice leading to delivery of incorrect treatment to the patients. Read More

Sci Rep 2020 Mar 19;10(1):4987. Epub 2020 Mar 19.

Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain.

In lobular capillary hemangioma (LCH), misnamed pyogenic granuloma, only sprouting angiogenesis (SA) has been considered. We assess the occurrence of intussusceptive angiogenesis (IA) in LCH and whether IA determines the specific and other focal patterns in the lesion. For this purpose, we study specimens of 120 cases of LCH, using semithin sections (in 10), immunohistochemistry, and confocal microscopy (in 20). Read More

J Histotechnol 2020 Mar 10:1-7. Epub 2020 Mar 10.

Department of Oral Pathology and Microbiology, I.T.S Centre for Dental Studies and Research, Ghaziabad, India.

Head and neck connective tissue lesions may have diverse calcifications within the fibrous connective tissue stroma. The perplexity involved in the identification and determination of the nature or degree of calcification through routine hematoxylin and eosin (H&E) stains necessitates the usage of a specific, simple, and cost- and time-effective differential staining techniques. The aim of the present study was to develop criteria to distinguish bone formation from bone resorption using methylene blue-acid fuchsin (MB/AF) stain and the role of collagen fibers in the identification of stromal calcifications using polarizing microscopy with picrosirius red stain. Read More

J Family Med Prim Care 2020 Jan 28;9(1):424-427. Epub 2020 Jan 28.

Department of Medicine, AIIMS Rishikesh, Uttarakhand, India.

Hepatic Tuberculosis (TB) is extremely rare without miliary involvement in immunocompetent patients. Even in countries like India where TB is a major public health problem only few cases have been diagnosed and treated. We report a case of an immunocompetent patient who presented with undiagnosed pyrexia of 11 days, was initially diagnosed as pyogenic liver abscess, he did not responded to treatment and on liver biopsy was diagnosed as hepatic tuberculoma. Read More

Autops Case Rep 2020 Jan-Mar;10(1):e2019127. Epub 2019 Dec 13.

Sri Balaji Vidyapeeth University, Indira Gandhi Institute of Dental Sciences, Department of Oral Pathology and oral Microbiology. Puducherry, Puducherry, India.

Peripheral Ameloblastoma (PA) is a benign odontogenic tumor, arising from the cell rest of Serres, reduced enamel epithelium and basal cells of the surface epithelium. Peripheral ameloblastoma is a rare odontogenic neoplasm occurring commonly in the mandibular gingiva. PA clinically resembles other peripherally occurring lesions like pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, and squamous papilloma. Read More

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):199-202

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Int J Surg Case Rep 2020 23;67:5-8. Epub 2020 Jan 23.

Shizuoka General Hospital, Shizuoka, Japan. Electronic address:

Introduction: Virtual enteroscopy (VE) has been developed to explore the entire small bowel. We have previously reported that VE can reveal elevated lesions measuring >10 mm in diameter. However, data on the existence of smaller polypoid lesions is scarce. Read More

Ophthalmology 2020 02;127(2):197

Fondation A. de Rothschild, Ophthalmology Department, Paris, France; Paris-Diderot University, Paris, France.

Acta Dermatovenerol Croat 2019 Dec;27(4):280-281

Luis Santiago, MD, Dermatology Department Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal;

Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Read More

Int J Clin Exp Pathol 2018 1;11(12):5755-5764. Epub 2018 Dec 1.

Division of Pathology, Niigata Medical Center Nishi-ku, Niigata, Niigata-Pref, Japan.

Slit and its receptor Roundabout (Robo) are important for neuronal development and neo-angiogenesis in various neoplastic and non-neoplastic diseases. Angiogenesis is a key factor for tumor growth and other angiogenesis-dependent diseases including rheumatoid arthritis, and chronic inflammation Recently, over-expression of Slit/Robo1 family proteins has been reported in several types of malignancy. We explored the expression of Robo1 in neoplastic and non-neoplastic diseases with a focus on newly formed blood vessels. Read More

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):197-199

Department of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Rom J Morphol Embryol 2019 ;60(3):811-822

Department of Implantology, Removable Prosthesis, Dental Prosthesis Technology, Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Background: Gingival overgrowth refers to an increase in the size of the gingival tissue. The etiology varies, and is often a multi-factor issue; what may contribute to gingival enlargement are aspects, such as disease, local and systemic conditions and idiopathic factors. The aim of the present study is to analyze and to correlate the clinical, epidemiological, imaging and histopathological (HP) features of gingival overgrowth in northeastern Romanian population. Read More

Ophthalmology 2020 May 30;127(5):689-695. Epub 2019 Dec 30.

Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.

Purpose: To review the literature on the efficacy and safety of bioengineered acellular dermal matrix (BADM) grafts for lower eyelid retraction repair.

Methods: A literature search was conducted in the PubMed database initially in January 2018 and updated in July 2019 to identify all studies in the English language literature on the use of BADM grafts in eyelid reconstruction. The searches yielded 193 citations, and 15 of the 34 articles selected for full review met all inclusion criteria for this assessment. Read More

Lung India 2020 Jan-Feb;37(1):71-72

Department of Pulmonary Medicine and Critical Care, AIIMS, Bhubaneswar, Odisha, India.

Head Neck Pathol 2020 Jan 2. Epub 2020 Jan 2.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Verruciform xanthoma (VX) of the oral cavity is an uncommon, reactive lesion of unknown etiology. In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Read More

Pathology 2020 Feb 27;52(2):269-271. Epub 2019 Dec 27.

Eye Center, University Freiburg, Germany. Electronic address:

Dent Traumatol 2019 Dec 23. Epub 2019 Dec 23.

Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia.

This paper reports a case of a labial pyogenic granuloma in the lower lip of a 15-year-old boy due to chronic trauma from the maxillary left central incisor. The case report is based on the CARE (CAse REport) Checklist developed by the Joanna Briggs Institute. A further aim is to present a mini-review about the link between labial pyogenic granuloma and trauma, through searching in three databases (MEDLINE, EMBASE, and Global Health) using a predefined search strategy and keywords. Read More

Ophthalmic Plast Reconstr Surg 2020 Mar/Apr;36(2):e46-e49

Pathology Service, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.

Pediatric-type follicular lymphoma is an uncommon B-cell lymphoma that primarily involves the lymph nodes of the head and neck of children and young adults. Ocular involvement is rare, with only 5 well-documented cases in the literature, all occurring in the conjunctiva. The authors describe a 20-year-old African American man with enlarging bilateral medial conjunctival nodules. Read More

Iran J Otorhinolaryngol 2019 Nov;31(107):399-402

Department of Otorhinolaryngology, Krishna Institute of Medical Sciences Deemed To Be University, Karad, 415110; Maharashtra, India.

Introduction: Lobular capillary hemangioma (LCH) is caused by exuberant neovascular response to infection, local irritation (e.g., trauma), or hormonal influence (e. Read More

Open Access Maced J Med Sci 2019 Sep 30;7(18):3015-3017. Epub 2019 Aug 30.

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.

Background: Tumor masquerading is a common phenomenon seen in clinical dermatology. While amelanotic melanoma is known to simulate pyogenic granuloma, a benign vascular tumour, the contrary has been reported exceptionally scarce.

Case Presentation: We present a 52-year-old woman with a slow-growing lesion on her right flank, which developed over 12 months. Read More

J Indian Soc Periodontol 2019 Nov-Dec;23(6):580-583

Department of Periodontics, SVS Institute of Dental Sciences, Yedira Post, Mahabubnagar, Telangana, India.

We report a case of palatal pyogenic granuloma following mucogingival surgery for alveolar socket preservation. A 24-year-old systemically healthy female underwent a pediculated palatal pedicle graft procedure to achieve soft tissue augmentation over a grafted maxillary anterior extraction site. After 1 month, a 15 mm × 20 mm exophytic growth extending from the palatal donor site to distance of 3-4 mm from the extraction socket was observed. Read More