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J Bone Jt Infect 2018 24;3(5):255-257. Epub 2018 Nov 24.

Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, Nantes, France.

After rifampin and levofloxacin treatment for a bone infection, a pyogenic granuloma due to a newly described species, developed on the tibia former external fixator. This rifampin resistant bacterium, selected during treatment, harbored a mutation in the gene. This case illustrates the possible selection of resistant mutant most likely due to the bacterial burden and therefore the importance of adequate bone infection treatment. Read More

J Am Dent Assoc 2018 Dec 7. Epub 2018 Dec 7.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion of unknown cause. The purpose of this study is to present a series of LJSGH cases and compare the findings with the literature.

Methods: After obtaining institutional review board approval, cases of biopsy-proven LJSGH from 2008 through 2018 were retrieved from the University of Pittsburgh Oral Pathology Biopsy Service archives and reviewed. Read More

Am J Otolaryngol 2018 Oct 29. Epub 2018 Oct 29.

Head and Neck Institute, Cleveland Clinic, Cleveland, OH, USA.

Pyogenic granuloma (PG) may involve gingival mucosa (granuloma gravidarum) in pregnancy but rarely involves the airway. This case report is perhaps the only reported presentation of PG in the larynx causing hemoptysis at a late stage of pregnancy. On laryngoscopic exam, a vascular, right false vocal fold neoplasm was identified with pathological characteristics consistent with PG. Read More

J Exp Ther Oncol 2018 Nov;12(4):291-294

MBBS student, Hind Institute of Medical Sciences, Lucknow, U.P, India.

Objective: A telangiectatic granuloma is a localized reactive lesion associated with prolonged irritation to the soft tissues. It may be misdiagnosed as a vascular malformation, hemangiomas, angiosarcomas, etc; as clinical presentation of the lesions resembles each other. Here, we present a case of asymptomatic swelling in the maxilla of a 17-year old female patient. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. In this continuing medical education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities. Read More

J Fr Ophtalmol 2018 Dec 13;41(10):991-992. Epub 2018 Nov 13.

Departement A of ophtalmology, Mohammed V university, Rabat, Maroc.

J Hand Surg Asian Pac Vol 2018 Dec;23(4):577-580

1 Department of Orthopaedics, Miri General Hospital, Miri, Malaysia.

Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular lesion of the skin or mucous membrane with rapid growth or repetitive trauma. Rarely seen in adult, its management varies and surgical intervention is usually common. We report a case of pyogenic granuloma of the right index finger in a 46-year-old gentleman who presented with painless swelling of the right index finger after a trivial injury. Read More

Ann Dermatol Venereol 2018 Dec 8;145(12):806-808. Epub 2018 Nov 8.

Service de dermatologie, CHRU de Lille, université de Lille, hôpital Claude-Huriez, rue Michel-Polonowski, 59000 Lille, France.

Indian J Dent Res 2018 Sep-Oct;29(5):678-682

Department of Periodontology, Government Dental College and Hospital, Mumbai, Maharashtra, India.

The peripheral giant cell granuloma (PGCG) is a benign oral lesion occurring on the gingiva and alveolar ridge. It is the most common oral lesion and occurs at an average age of 30 years. The upsurge in the levels of estrogen and progesterone in pregnancy leads to a plethora of changes in various parts of human body, including the oral cavity. Read More

Ophthalmic Plast Reconstr Surg 2018 Nov 5. Epub 2018 Nov 5.

Department of Ophthalmology and Visual Sciences, W. K Kellogg Eye Center, Ann Arbor, Michigan U.S.A.

Purpose: To describe the use of cryopreserved ultra-thick human amniotic membrane for management of anophthalmic socket contracture.

Methods: A chart review was performed to identify patients undergoing fornix reconstruction with cryopreserved ultra-thick human amniotic membrane for management of anophthalmic socket contracture. Patient demographics, disease etiology, and data regarding postoperative prosthesis fit and complications were collected. Read More

Case Rep Dent 2018 14;2018:5180385. Epub 2018 Oct 14.

School of Dentistry, University Center of Patos de Minas (UNIPAM), Patos de Minas, MG, Brazil.

Oral surgery to remove pyogenic granuloma in a high-risk patient is reported. A 47-year-old man with gastroesophageal reflux disease, diabetes mellitus II, dyslipidemia, and chronic coronary insufficiency (myocardial infarction within 2 years) with episodes of unstable angina was submitted to an excisional biopsy of hemorrhagic lesion in the lingual right mandibular gingiva. During dental treatment, the arterial blood pressure, oxygen saturation, heart rate, and electrocardiogram were monitored. Read More

J Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, National Cancer Center Hospital East, Chiba, Japan.

Photochem Photobiol Sci 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, Medical University of Vienna, Austria.

Background And Objective: Pyogenic granuloma is a common benign vascular lesion of the skin and mucosa prone to ulceration and bleeding. Current therapeutic approaches include surgical excision, removal by means of electro caustic therapy, cryotherapy, and ablation with CO2 or vascular lasers. The purpose of this study was to investigate the efficacy of a 532 nm potassium-titanyl-phosphate laser (KTP-laser) for the treatment of pyogenic granulomas in terms of efficacy, advantages in clinical outcome, technique and associated side effects. Read More

Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39

Institut Universitaire du Cancer Toulouse - Oncopole, 1 avenue Irène Joliot-Curie, 31059, TOULOUSE Cedex 9, France.

Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25-85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. Read More

Int J Dermatol 2018 Oct 21. Epub 2018 Oct 21.

Dermatology Department, University of Patras, Patras, Greece.

Pyogenic granuloma is a benign vascular proliferation of the skin and mucous membranes, whose pathogenesis is not fully understood. Despite its benign nature, it can have a significant negative impact on patients' quality of life, and therefore appropriate therapy is needed. Over the years, a lot of therapeutic modalities have been used in order to successfully treat this condition. Read More

G Ital Dermatol Venereol 2018 Oct 11. Epub 2018 Oct 11.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Pediatr Dermatol 2018 Oct 15. Epub 2018 Oct 15.

Dermatopathology Division, Department of Pathology and Laboratory Medicine, Sylvester Comprehensive Cancer Center and Miller School of Medicine, University of Miami, Miami, Florida, USA.

Disseminated congenital pyogenic granuloma (DCPG) is an uncommon condition. Individual lesions of DCPG share clinical and histologic similarities with infantile hemangioma (IH); endothelial glucose transporter 1 (GLUT-1), which is highly expressed in IH but generally not in pyogenic granulomas (PG), is an important diagnostic tool. Treatment for DCPG remains difficult. Read More

Dig Liver Dis 2018 Sep 27. Epub 2018 Sep 27.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Ann Dermatol Venereol 2018 Oct 9. Epub 2018 Oct 9.

Service de dermatologie, CHR Metz-Thionville, 57000 Metz, France.

Background: Cutaneous metastases (CM) on the extremities are rare complication of cancer with poor prognosis. In general, lesions simulate an infection. Herein, we report two new cases with atypical presentation. Read More

Ann Med Surg (Lond) 2018 Nov 4;35:158-162. Epub 2018 Oct 4.

Plastic and Reconstructive Surgery, Surgery Department, King Fahad National Guard Hospital, King Abdulaziz Medical City (KAMC), Saudi Arabia.

Background: Fibro-osseous pseudotumor (FOPD) of the digit is a rare benign lesion of subcutaneous tissue characterized by fibroblastic proliferation and osteoid formation. Herein, we present a case of massive FOPD lesion in the base of ring finger with extensive involvement of the neurovascular bundles with challenging surgical approach.

Case Description: A 27-year old female patient, presented with 7-months history of a progressively enlarging mass on her left hand. Read More

Br J Dermatol 2018 Oct 9. Epub 2018 Oct 9.

Section of Dermatology, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.

J Am Coll Clin Wound Spec 2016 5;8(1-3):39-41. Epub 2017 Sep 5.

Kirikkale University Faculty of Medicine, Department of Dermatology and Venerology, No:14 Yenisehir District, Tahsin Duru Avenue, Yahsihan, Kirikkale, Turkey.

Pyogenic granuloma (PG) is a common, acquired, benign vascular reactive proliferation. This article presents the unique and successful pulsed dye laser treatment of a labial PG on a 60-year-old patient. Read More

Indian Dermatol Online J 2018 Sep-Oct;9(5):293-298

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.

Paronychia is a painful inflammatory disorder of the nail fold. Periungual pyogenic granuloma - a benign vascular tumor of the capillaries - can develop as a complication of paronychia. We report both, paronychia and periungual pyogenic granuloma, as possible adverse events during systemic drug-therapy. Read More

G Ital Dermatol Venereol 2018 Sep 20. Epub 2018 Sep 20.

San Gallicano Dermatological Institute IRCCS, Rome, Italy -

Arq Bras Oftalmol 2018 Sep-Oct;81(5):366-370

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To evaluate the outcomes of dermis-fat graft procedure for orbital volume replacement in anophthalmic socket.

Methods: A retrospective chart review was performed studying all dermis-fat graft surgeries done at King Khlaed Eye Specialist Hospital in the last 10-year period. Sixty-two anophthalmic socket carriers underwent dermis-fat graft during the study period. Read More

Open Dent J 2018 29;12:560-566. Epub 2018 Aug 29.

Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: The isolation of stem cells from pathologically damaged dental tissues has been examined only by a few studies. The purpose of this study was to evaluate the possibility of isolation of stem cells from pyogenic granuloma.

Methods: Pyogenic granuloma tissues were enzymatically digested and the resulting single cells were cultured. Read More

Orv Hetil 2018 Sep;159(37):1516-1524

Fogorvostudományi Kar, Szájsebészeti Tanszék, Szegedi Tudományegyetem Szeged.

Introduction: In a clinicopathological retrospective epidemiological study we investigated benign tumors and tumor-like lesions located in the orofacial region, diagnosed at the Universiy of Szeged, Department of Oral Medicine.

Method: During a 54-year period (1960-2014), 14 661 biopsies were taken. The included subjects were 7491 patients diagnosed with benign tumors and tumor-like lesions. Read More

J Dermatol 2018 Sep;45(9):1145-1146

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

J Orthop Case Rep 2018 Mar-Apr;8(2):47-50

Department of Orthopaedics, St. John's Medical College, Bengaluru, Karnataka, India.

Introduction: The swellings of foot are common but the lesions of metatarsals are rare. The purpose is to highlight these four cases which had almost common presentations but had different etiologies.

Case Report: A series of four cases all of which had similar presentation, but different etiologies. Read More

Case Rep Dent 2018 12;2018:2474706. Epub 2018 Aug 12.

Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome, Rome, Italy.

The aim is to discuss four cases of gingival reactive hyperplastic lesions in patients with a history of excision of oral neoplastic lesions and rehabilitation by a free revascularized flap of the iliac crest. One female and 3 male patients were referred due to the presence of exophytic lesions at the rehabilitated sites. The clinical examination revealed that the poor oral hygiene was the common trigger factor in all the cases, in addition to trauma from the upper left second molar in the first case, pericoronitis related to a partially erupted lower right third molar in the third case, and poor stability of an upper removable partial denture in the fourth case. Read More

Dent Med Probl 2018 Jan-Mar;55(1):83-86

Department of Periodontology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Mangalore, India.

Most of the reactive lesions in the oral cavity arise from gingiva. Fibroma, focal fibrous hyperplasia, pyogenic granuloma, and peripheral ossifying fibroma are the commonly encountered lesions of gingiva. Peripheral ossifying fibroma (POF) frequently arises from the peripheral tissues like gingiva. Read More

J Indian Soc Periodontol 2018 Jul-Aug;22(4):360-364

Department of Periodontology, The Oxford Dental College, Bengaluru, Karnataka, India.

Pyogenic granuloma (PG) is an inflammatory hyperplastic lesion of the oral cavity. The most common etiological factors for PG are low-grade local irritation, traumatic injury, or hormonal factors. Clinically, it appears to be smooth or lobulated exophytic lesion. Read More

Clin J Gastroenterol 2018 Aug 9. Epub 2018 Aug 9.

Pediatric Gastroenterology Unit, Oporto Hospital Center, Porto, Portugal.

We describe the case of a previously healthy 8-year-old girl presenting with a 1-year history of iron deficiency anemia. There was no report of hematemesis, abdominal pain or melena. Laboratory work-up excluded iron malabsorption as the underlying cause. Read More

BMJ Case Rep 2018 Aug 9;2018. Epub 2018 Aug 9.

Department of Conservative Dentistry and Endodontics, King George's Medical University, Lucknow, Uttar Pradesh, India.

Pyogenic granuloma is a 'reactive lesion' in the oral cavity caused due to hormonal imbalance or poor oral hygiene. There are different methods to excise this lesion but most successful is treatment with lasers. Currently, there are different lasers available commercially and are used by clinicians to excise this lesion. Read More

J Craniofac Surg 2018 Nov;29(8):2160-2163

Department of Biomedical, Odontostomatological, Sciences and Morphological and Functional Images, School of Dentistry, University of Messina, Messina.

The use of laser in oral surgery and periodontology is a matter of debate, mainly because of the lack of consensual therapeutic protocols. The aim of this study was to evaluate the surgical advantages of diode laser versus traditional surgery with a cold blade for the surgical excision of pyogenic granuloma (PG). Twenty-one patients (10 males, 11 females, aged 19-66 years; mean age: 46. Read More

Lasers Med Sci 2018 Jul 11. Epub 2018 Jul 11.

Dermatology Department, Beijing Chaoyang Hospital, Capital Medical University, 8# South Road, Worker's Stadium, Chaoyang District, Beijing, China.

Pyogenic granuloma (PG) is a common benign vascular proliferation which often occurs on the head, neck, hands, and feet. Among the various treatment options for PG, surgical excision is the most effective treatment which offers the lowest overall recurrence rates and also provides the exact diagnosis. However, it could have difficulties to do the surgery when lesions are located on the fingers and toes, especially very near to the nails, so laser may be a very good alternative choice. Read More

J Korean Assoc Oral Maxillofac Surg 2018 Jun 26;44(3):136-139. Epub 2018 Jun 26.

Department of Oral Medicine and Pathology, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.

This study presents a case of an oral angioleiomyoma along with its clinical diagnostic approach and laboratory confirmation. The differential diagnosis, especially from angioleiomyosarcoma, is also included. A 51-year-old patient presented with a tumor-like lesion on his upper labial mucosa. Read More

J Indian Soc Periodontol 2018 May-Jun;22(3):273-276

Department of Oral and Maxillofacial Pathology and Oral Microbiology, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India.

Exophytic gingival lesions are more frequently encountered intraorally, out of which few are reactive in nature. Pyogenic granuloma (PG) is one of the commonly occurring reactive benign mucocutaneous lesions; exact etiopathogenesis remains unclear. Although surgical excision is the treatment of choice, sometimes it may induce residual soft defect formation which further creates an esthetic problem, root sensitivity, etc. Read More

Pediatr Dermatol 2018 Sep 1;35(5):e300-e303. Epub 2018 Jul 1.

Department of Dermatology, University of California, San Francisco, CA, USA.

We present three patients with agminated pyogenic granulomas who experienced significant decrease in size and bleeding with treatment with topical timolol solution with minimal side effects. One patient had complete clinical resolution. For patients with agminated pyogenic granuloma who may otherwise have limited treatment options, timolol is an effective potential solution. Read More

Int Wound J 2018 Dec 29;15(6):909-913. Epub 2018 Jun 29.

Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.

Mucous membrane pemphigoid (MMP) is a group of chronic autoimmune sub-epithelial blistering disorders, which mostly affect the oral mucosa and the conjunctiva. MMP is very diverse in terms of both the clinical and immunological features (IgG and IgA autoantibodies may react with different antigens). MMP can be induced by infections and medication, including ophthalmologic medication, which may lead to the development of eye lesions. Read More

J Coll Physicians Surg Pak 2018 Jul;28(7):575

Department of Oral and Maxillofacial Pathology, King George's Medical University (KGMU), Lucknow, Uttar Pradesh, India.

Eye Contact Lens 2018 Nov;44 Suppl 2:S333-S337

Department of Ophthalmology (C.-J.H., C.-J.L., W.-H.T., Y.-C.H., I.-J.W., F.-R.H., W.-L.C.), National Taiwan University Hospital, Taipei, Taiwan; and Center of Corneal Tissue Engineering and Stem Cell Biology (F.-R.H., W.-L.C.), National Taiwan University Hospital.

Purpose: To evaluate the complications and the treatment results of SmartPlug-related complications.

Methods: Retrospective review of all patients from a single medical hospital who received SmartPlug (Medennium, Inc., Irvine, CA) insertions from October 2007 to February 2014. Read More

J Clin Exp Dent 2018 Jun 1;10(6):e561-e566. Epub 2018 Jun 1.

BDS, MBA, PhD, Assistant Professor, Oral Diagnostic Sciences Department, King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia.

Background: The gingiva is part of the periodontium supporting structures surrounding the teeth and commonly involved in gingival and periodontal conditions. Assessing the distribution of gingival lesions is important for evaluating the prevalence of periodontal disease in the population to optimize the oral health care services. The purpose of this study is to report the frequency and distribution of gingival lesions biopsied from 1996-2016. Read More

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

Am J Dermatopathol 2018 Jul;40(7):519-522

Department of Pathology, University of Virginia, Charlottesville, VA.

Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease. Read More

Laser Ther 2018 Mar;27(1):61-64

Department of pediatric surgery, Dokkyo Medical University Koshigaya Hospital.

Background And Aims: It is generally thought that bleeding from a hemangioma is difficult to stop. With development of the long pulse dye laser (LPDL), it has become possible to treat hemangioma with a large blood vessel diameter. Thus, it is effective in treating infantile hemangioma and pyogenic granuloma. Read More

Biotech Histochem 2018 21;93(5):336-339. Epub 2018 May 21.

a Department of Oral and Maxillofacial Pathology , St. Joseph Dental College , Eluru 534004 , Andhra Pradesh , India.

Toto bodies are eosinophilic structures that resemble the cells of the superficial cell layer of the oral epithelium. Toto bodies commonly are associated with inflammatory gingival and other mucosal lesions including pyogenic granuloma, irritational fibroma, epulis fissuratum, peripheral giant cell granuloma and inflammatory hyperplastic gingivitis. We evaluated staining characteristics of Toto bodies to establish their origin and to identify their significance in lesions. Read More