J Audiol Otol 2018 Apr 17. Epub 2018 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University Medical Center, Eulji University School of Medicine, Daejeon, Korea.

A pyogenic granuloma is one of the most common benign tumors in the head and neck. However, it rarely occurs in the external auditory canal (EAC). We report a case of a pyogenic granuloma that involved the both EAC in a pregnant woman. Read More

Clin Case Rep 2018 Apr 27;6(4):690-693. Epub 2018 Feb 27.

Department of PathologyChitwan Medical College Teaching HospitalP.O. Box 42, Bharatpur 10ChitwanNepal.

Pyogenic granuloma is a benign vascular neoplasm of the oral cavity that usually presents as a small nodular lesion, the gingiva being the commonest site. Occasionally it occurs at uncommon sites with unusual sizes. Here we describe two cases of oral pyogenic granulomas that had an unusual presentation. Read More

Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.

Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp); São José dos Campos, SP, Brazil.

Intravascular papillary endothelial hyperplasia (IPEH) is an unusual benign, non-neoplastic vascular lesion that usually occurs in skin, but is uncommon in the oral cavity. Herein, we review the pertinent literature of oraiiPEH and report a new mixed form. A 61-year- old man presented with an ulcerated nodule in the lingual portion of the gingiva related to the left mandibular canine. Read More

Medicine (Baltimore) 2018 Mar;97(13):e9934

Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo.

Rationale: Oral metastases occur more commonly in bone, but can also manifest in soft tissues and eventually resemble a reactive lesion. Few cases of oral metastases mimicking reactive lesions in soft tissues have been reported to date.

Patient Concerns: We report a metastasis of gastric carcinoma (GC) to the oral mucosa without bone involvement in a 43 yom clinically and microscopically mimicking a reactive lesion. Read More

Pediatr Dermatol 2018 Mar;35(2):237-238

Am J Dermatopathol 2018 Apr;40(4):231-239

Professor, Department of Dermatology, Mayo Clinic, Rochester, MN.

Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. Read More

J Obstet Gynaecol 2018 Mar 21:1-3. Epub 2018 Mar 21.

a Faculty of Dentistry , University of British Columbia , Vancouver , Canada.

Indian J Dermatol Venereol Leprol 2018 Mar 16. Epub 2018 Mar 16.

Department of Surgery, VMMC, Safdarjung Hospital, New Delhi, India.

Urol Case Rep 2018 May 17;18:1-2. Epub 2018 Feb 17.

Royal Liverpool & Broadgreen NHS Trust, Prescot Road, Liverpool, United Kingdom.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S102-S107

Division of Oral and Maxillofacial Pathology, Columbia University Medical Center, New York, USA.

Tumor metastasis to the oral cavity is rare and is usually an indication of late-stage disease and poor prognosis. While, there are reports of renal cell carcinoma (RCC) metastatic to oral cavity, vast majority of them are to the jaw. Herein, we present a case of a 78-year-old woman with RCC metastasis limited to the oral soft tissue without any bone involvement. Read More

Radiol Case Rep 2018 Feb 23;13(1):248-253. Epub 2017 Dec 23.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1405 Clifton Rd NE, Atlanta, GA 30322 USA.

A 4-year-old girl presented repeatedly with a complicated occipital mass, which was erroneously treated as a pyogenic granuloma. Imaging performed before a planned surgical resection detected an underlying intraoccipital dermoid with a sinus tract to the skin surface and extension into the posterior fossa. This case highlights the value of high-resolution computed tomography imaging for depiction of anatomic details and the value of magnetic resonance imaging for differential diagnosis and surgical management. Read More

Open Access Maced J Med Sci 2018 Jan 30;6(1):52-54. Epub 2017 Dec 30.

Medical Institute of the Ministry of Interior, Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.

Background: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy. Read More

J Indian Soc Periodontol 2017 Jul-Aug;21(4):258-263

Department of Oral and Maxillofacial Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.

Objective: This study reviews, analyzes, and compares the demographic data, histopathological features and discusses the treatment and prognosis of reactive lesions (RLs).

Materials And Methods: Retrospective study was performed on the departmental archives from July 2006 to July 2016 (total 5000 cases) comprising of 659 cases of RLs of the oral cavity. The recorded data included age, gender, size, site, duration, habits, etiology, histopathological diagnosis, treatment, and prognosis. Read More

J Dermatol 2018 Feb 14. Epub 2018 Feb 14.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Asian Cardiovasc Thorac Ann 2018 Mar 14;26(3):224-226. Epub 2018 Feb 14.

1 Thoracic Surgery Unit, University Hospital Careggi, Florence, Italy.

We report a case of intravenous lobular capillary hemangioma in the subclavian vein, causing venous thoracic outlet syndrome. A 32-year-old woman was referred to our unit with facial and left arm oedema. Ultrasound evaluation, computed tomography and magnetic resonance imaging showed a hypervascular mass in the middle portion of the subclavian vein, with arrest of venous flow. Read More

Indian J Dent Res 2018 Jan-Feb;29(1):61-66

Department of Community Dentistry, MIDSR Dental College, Latur, India.

Context: The reactive lesions are relatively common in the oral cavity because of the frequency with which the tissues are injured. They often result from a known stimulus or injury such as dental plaque, calculus, or foreign material.

Aims: : The aim of this study was to review the clinicopathologic features of reactive hyperplastic lesions (RHLs) of the oral cavity at MIDSR, Dental College and Hospital, Latur, Maharashtra, and to compare these data with those of previously reported studies. Read More

J Indian Soc Periodontol 2017 May-Jun;21(3):241-244

Department of Periodontology, Dayananda Sagar College of Dental Sciences, Bengaluru, Karnataka, India.

Pyogenic granuloma (PG) is a nonneoplastic, tumor-like growth commonly seen in the oral mucosa or skin. Although nonpathological, its existence might lead to complications such as secondary infections or diastema formation. Hence, surgical removal of the growth seems mandatory. Read More

Support Care Cancer 2018 May 10;26(5):1353-1355. Epub 2018 Feb 10.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.

J Invest Dermatol 2018 Feb 8. Epub 2018 Feb 8.

Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:

We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model; Microsoft Research Asia, Beijing, China) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (19,398 images in total). The trained model was validated with the testing portion of the Asan, Hallym and Edinburgh datasets. Read More

Ophthal Plast Reconstr Surg 2018 Feb 5. Epub 2018 Feb 5.

Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China.

Purpose: BRAF V600E mutations were recently identified in some pyogenic granulomas of skin, particularly lesions arising in patients with port wine stains. In this study, the authors analyzed BRAF gene status in 28 periocular pyogenic granulomas to determine its role in their pathogenesis.

Methods: Retrospective review of ophthalmic pathology archives from 2007 to 2016 was used to identify pyogenic granulomas of the conjunctiva, eyelid, and orbit. Read More

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):415-420

Department of Oral Pathology and Microbiology, Government Dental College, Kottayam, Kerala, India.

Hemangioendothelioma commonly occurs in the superficial or deep soft tissue of the extremities, lungs, liver, bone and lymph nodes, with oral cavity being a rare location. It is usually benign but can show variable grades of malignancy. According to the histological presentation, hemangioendothelioma has been classified as epithelioid, Kaposiform, hobnail (Dabska-Retiform), epithelioid sarcoma like and composite. Read More

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):382-386

Department of Periodontics, Post Graduate Institute of Dental Sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India.

Background And Objective: Reactive proliferations of oral cavity comprise pyogenic granuloma (PG), fibrous hyperplasia (FH), peripheral ossifying fibroma (POF), and peripheral giant-cell granuloma (PGCG). They often pose diagnostic challenges due to their overlapping clinical and histopathological features. This study was conducted to determine the frequency and clinicopathological correlation of reactive hyperplastic lesions in the oral cavity reported in our institute and compared it with other previous studies. Read More

J Indian Soc Periodontol 2017 Jan-Feb;21(1):76-79

Department of Periodontology, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, Maharashtra, India.

The aim of the present study was to assess the clinico-histopathological picture and to examine the recurrence of various localized hyperplastic gingival growths after their surgical treatment. Twenty patients of localized hyperplastic gingival outgrowth were evaluated in the present clinico-histopathological study. The data regarding age, sex, location, size, and duration of lesion were summarized. Read More

J Gastrointest Surg 2018 Jan 26. Epub 2018 Jan 26.

Department of Gastroenterology, Francisco Gentil Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal.

Pyogenic granuloma is a benign vascular lesion, uncommon in the gastrointestinal tract, and extremely rare in the small bowel. The diagnosis can be challenging prior to surgery, because of its unusual endoscopic appearance.We present a case of pyogenic granuloma of the jejunum diagnosed by capsule endoscopy and double-balloon enteroscopy and successfully managed by surgical resection. Read More

JAAPA 2018 Feb;31(2):27-29

At Stony Brook (N.Y.) University Hospital, Joseph Said is an orthopedic surgery resident, Syed T. Hoda is a pathologist, and Samantha Muhlrad is a clinical assistant professor of orthopedic surgery. The authors have disclosed no potential conflicts of interest, financial or otherwise.

This article describes a patient whose cutaneous pyogenic granuloma was mistaken for infection after injury from a fractured smartphone screen. Clinicians should suspect pyogenic granuloma in patients with these types of injuries so that patients can avoid unnecessary procedures, antibiotics, and discomfort. Read More

J Am Acad Dermatol 2018 Jan 12. Epub 2018 Jan 12.

Department of Dermatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Contemp Clin Dent 2017 Oct-Dec;8(4):667-671

Department of Periodontics, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Localized gingival overgrowths are commonly encountered in our day-to-day clinical practice and often present a diagnostic dilemma to the clinicians. These lesions vary depending on the location, site, extent, histology, and/or etiopathology. Although most of the localized gingival enlargements represent the reactive lesion to plaque accumulation, the differential diagnosis ranges from peripheral fibroma to pyogenic granuloma to peripheral fibroma with ossification and/or calcification, peripheral giant cell granuloma, etc. Read More

Eur J Breast Health 2018 Jan 1;14(1):29-34. Epub 2018 Jan 1.

Department of Radiology, Taksim Gaziosmanpaşa Training and Research Hospital, İstanbul, Turkey.

Objective: The purpose of this study is to present mammography and ultrasound findings of male breast lesions and to investigate the ability of diagnostic modalities in estimating the evolution of gynecomastia.

Materials And Methods: Sixty-nine male patients who admitted to Taksim and Bakirkoy Education and Research Hospitals and underwent mammography (MG) and ultrasonography (US) imaging were retrospectively evaluated. Duration of symptoms and mammographic types of gynecomastia according to Appelbaum's classifications were evaluated, besides the sonographic findings in mammographic types of gynecomastia. Read More

J Am Acad Dermatol 2018 Jan 4. Epub 2018 Jan 4.

Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. Electronic address:

Pediatr Dermatol 2018 Jan 20;35(1):117-120. Epub 2017 Dec 20.

Section of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Saint Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Background: Pyogenic granuloma (PG) is a common, acquired, benign vascular neoplasm of the skin and mucous membranes. It occurs most often in children and adolescents. First-line treatment options for PG are based on destructive approaches. Read More

Clin Exp Dermatol 2018 Mar 13;43(2):117-123. Epub 2017 Dec 13.

Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY, USA.

Acral melanoma (AM) is a rare subtype of cutaneous malignant melanoma found on acral skin, primarily on the soles of the feet. Although rare, it is the most common subtype of melanoma found in patients of African or Asian ethnicity and has a poor prognosis, often because of the more advanced stage of presentation at diagnosis. In the second of this two-part series, we review the clinical presentation, histopathology, diagnosis and management of AM. Read More

Otolaryngol Clin North Am 2018 Feb;51(1):89-97

Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue Boston, MA, 02115, USA. Electronic address:

Vascular tumors are benign neoplasms, which result from proliferating endothelial cells. These lesions present during infancy or childhood, may affect any location, and exhibit postnatal growth. Local complications include bleeding, tissue destruction, and pain whereas systemic sequelae include thrombocytopenia, congestive heart failure, and death. Read More

Indian Dermatol Online J 2017 Nov-Dec;8(6):523-524

Department of Dermatology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Skeletal Radiol 2018 May 1;47(5):711-716. Epub 2017 Dec 1.

Department of Pathology, Hofstra Northwell School of Medicine, 6 Ohio Drive, New Hyde Park, NY, 11040, USA.

A 32-year-old male presented with a right thumb lesion of 11-month duration. A clinical diagnosis of pyogenic granuloma was entertained but the lesion failed to respond to conservative therapy and eventually necessitated amputation of his thumb. MRI of the right thumb showed an ill-defined, heterogeneously enhancing, infiltrating mass within the dorsal soft tissues abutting the distal phalanx and measuring 4. Read More

Mol Clin Oncol 2017 Nov 19;7(5):874-876. Epub 2017 Sep 19.

Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare chronic inflammatory disorder of unknown etiology that most commonly presents as painless lymphadenopathy or subcutaneous masses in the head and neck region. The pathogenesis of the disease is not yet clear. The differential diagnosis is determined using characteristic histological features, such as significant vascular proliferation, lymphocytes and eosinophil inflammation in the dermis. Read More

Indian J Dermatol Venereol Leprol 2017 Nov 1. Epub 2017 Nov 1.

Department of Pathology, Kırklareli State Hospital, Kırklareli, Turkey.

Acral angioosteoma cutis is a rare and benign cutaneous lesion clinically characterized by an exophytic growth resembling pyogenic granuloma on the acral skin; first described in 2006. Its pathogenesis is still unclear while well-formed capillaries, pale stroma, bland fibroblast-like cells, and multiple tiny spicules of woven bone constitute the histological hallmarks. Here, we present a case of acral angioosteoma cutis in a 34-year-old man to increase awareness regarding this rare condition. Read More

Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.

Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,

Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

J Craniofac Surg 2018 Jan;29(1):e49-e50

School of Medicine, University of Seville, Virgen del Rocio University Hospital, Seville, Spain.

Pregnancy pyogenic granuloma is considered a benign common growth that usually develops on the gingiva in the second and third trimester of gestation, in response to local irritation, trauma or hormonal factors. Here, the authors report a case of a primigravida who presented an extragingival pyogenic granuloma with a rapid progression in the post-partum. The occurrence on the lower lip in the first few days after delivery was a relatively rarity in the present case which provoked a meaningful state of anxiety and cancerophobia to the female. Read More

Dtsch Arztebl Int 2017 Sep;114(39):659

J Craniofac Surg 2017 Nov;28(8):2068-2072

*Department of Plastic and Reconstructive Surgery †Department of Pathology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.

Pyogenic granuloma (PG) is a type of vascular tumor for which the growth mechanism is poorly understood. Estrogen and progesterone may influence vascular malformations by increasing neovascularization in the lesions. Pregnancy tumor is a term for PG that occurs on the gingival mucosa of pregnant women in response to local irritation or injury. Read More

Radiographics 2017 Oct;37(6):1704-1730

From the Department of Radiology, Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH 43205 (D.P.R.); and Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio (E.S.O., B.L.K.).

A wide range of masses develop in the nose, nasal cavity, and nasopharynx in children. These lesions may arise from the nasal ala or other structures of the nose, including the mucosa covering any surface of the nasal cavity, the cartilaginous or osseous portion of the nasal septum, the nasal turbinates, and the nasal bones. Lesions may also arise from the nasopharynx or adjacent structures and involve the nose by way of direct extension. Read More

J Contemp Dent Pract 2017 Oct 1;18(10):981-985. Epub 2017 Oct 1.

Department of Periodontology, Lake Erie College of Osteopathic Medicine, School of Dental Medicine, Bradenton, Florida, USA, Phone: +9414051506, e-mail:

Introduction: The aim of this study is to describe a case of a melanotic macule found in conjunction with a giant cell fibroma (GCF). For oral pigmented lesions without an identifiable etiologic factor, critical factors in determining the differential diagnosis are clinical history, symmetry, and uniformity of the lesions. Potential differential diagnosis includes racial pigmentation, endocrine disturbance, Peutz-Jeghers syndrome, trauma, hemochromatosis, oral malignant melanoma, or idiopathic etiology and melanotic macules. Read More

J Dtsch Dermatol Ges 2018 Jan 6;16(1):74-75. Epub 2017 Oct 6.

Department of Dermatology and Venereology, Fırat University Medical Faculty, Elazig, Turkey.

JAAD Case Rep 2017 Sep 8;3(5):451-453. Epub 2017 Sep 8.

Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, California.

An Sist Sanit Navar 2017 Dec 29;40(3):471-474. Epub 2017 Dec 29.

Hospital Universitario Araba..

Odontogenic cutaneous fistula (OCF) is the result of an abnormal canalization originating from chronic periapical infection. It represents a diagnostic challenge, as it is frequently misdiagnosed as dermatological lesion. There is a broad differential diagnosis, including pyogenic granuloma, cutaneous tuberculosis or congenital malformations, among others. Read More

Arch Craniofac Surg 2017 Mar 25;18(1):44-45. Epub 2017 Mar 25.

Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.

Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. Read More

Arch Craniofac Surg 2017 Mar 25;18(1):16-20. Epub 2017 Mar 25.

Department of Plastic and Reconstructive Surgery, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Background: Pyogenic granuloma (PG) is a benign vascular lesion of the mucosa and skin. Recent studies of the epidemiology of PG are rare. We aimed to retrospectively analyze characteristics of PG cases in South Korea. Read More