Am J Dermatopathol 2018 Jul;40(7):519-522

Department of Pathology, University of Virginia, Charlottesville, VA.

Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease. Read More

Laser Ther 2018 Mar;27(1):61-64

Department of pediatric surgery, Dokkyo Medical University Koshigaya Hospital.

Background And Aims: It is generally thought that bleeding from a hemangioma is difficult to stop. With development of the long pulse dye laser (LPDL), it has become possible to treat hemangioma with a large blood vessel diameter. Thus, it is effective in treating infantile hemangioma and pyogenic granuloma. Read More

Biotech Histochem 2018 May 21:1-4. Epub 2018 May 21.

a Department of Oral and Maxillofacial Pathology , St. Joseph Dental College , Eluru 534004 , Andhra Pradesh , India.

Toto bodies are eosinophilic structures that resemble the cells of the superficial cell layer of the oral epithelium. Toto bodies commonly are associated with inflammatory gingival and other mucosal lesions including pyogenic granuloma, irritational fibroma, epulis fissuratum, peripheral giant cell granuloma and inflammatory hyperplastic gingivitis. We evaluated staining characteristics of Toto bodies to establish their origin and to identify their significance in lesions. Read More

J Indian Soc Periodontol 2018 Mar-Apr;22(2):174-177

Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

Pyogenic granuloma (PG) is a reactive hyperplasia of connective tissue that occurs in response to low-grade local irritation, traumatic injury, foreign materials, or hormonal causes and rarely associated with bone loss. Although solitary PG is a common lesion in the orofacial region, presence of multiple such lesions at the same time with associated bone loss is rare. In addition, repeated recurrences of such lesions sometimes frustrate the clinician. Read More

J Cutan Pathol 2018 May 15. Epub 2018 May 15.

Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.

Background: We investigated 2 cases of deceptively bland cutaneous angiosarcoma (AS), which showed a uniform clinical presentation with a rapidly growing tumor on the nose. It remains unclear whether this was a primary cutaneous manifestation or a metastasis. Both tumors initially presented a high histologic overlap with a benign vascular tumor. Read More

Skin Appendage Disord 2018 Apr 31;4(2):96-97. Epub 2017 Aug 31.

Department of Dermatology, Brugmann - St Pierre and Queen Fabiola Children's University Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

J Clin Pediatr Dent 2018 May 15. Epub 2018 May 15.

Pyogenic granuloma, also called lobular capillary hemangioma, is a benign vascular lesion of the skin and mucous membranes. While the majority of pyogenic granulomas in the oral cavity involve the gingiva, they also infrequently present at other sites including lips, oral mucosa, palate, and tongue. We report a case of a pyogenic granuloma of the tongue in a five-year old female patient. Read More

J Investig Clin Dent 2018 May 11:e12342. Epub 2018 May 11.

Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, College of Dentistry, Memphis, TN, USA.

Reactive lesion formation around dental implants a complication that has been given much consideration. These lesions can lead to marginal bone loss, and consequently, implant failure. In the present systematic review, all reported reactive lesions associated with dental implants in the literature were assessed. Read More

Melanoma Res 2018 Aug;28(4):363-367

Department of Dermatology, Laser Unit, Rabin Medical Center.

Amelanotic melanomas (AMMs) account for a small proportion of all melanomas. They pose a risk of delayed diagnosis and, consequently, poor prognosis. AMMs may atypically present as a pyogenic granuloma-like lesion. Read More

Int J Surg Pathol 2018 May 1:1066896918773476. Epub 2018 May 1.

1 Department of Pathology and Laboratories, Fundación Santa Fe de Bogotá, Bogotá DC, Colombia.

Pyogenic granuloma (PG) is a capillary hemangioma mainly found in the skin and oral mucosa, but rarely described in the esophagus. We report the case of a 66-year-old man who consulted for retrosternal pain. Endoscopic studies showed a 28-mm polypoid mass located at the distal esophageal mucosa. Read More

J Oral Maxillofac Pathol 2018 Jan-Apr;22(1):147

Department of Oral and Maxillofacial Pathology, Dental and Periodontal Research Centre, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Many studies have reported that macrophages and eosinophils are involved in the pathogenesis of several diseases. To the best of our knowledge, this is the first study comparing macrophages and eosinophils in oral reactive lesions.

Aims: In this study, we aimed to determine the contribution of macrophages and eosinophils to the pathogenesis of oral reactive lesions and the relationships between these biomarkers and the diverse histopathologic features. Read More

Gen Thorac Cardiovasc Surg 2018 May 2. Epub 2018 May 2.

Department of Cardiovascular Surgery, Ishikiri Seiki Hospital, 18-28 Yayoi-cho, Higashiosaka, Osaka, 579-8026, Japan.

We herein report an unreported case of pyogenic granuloma that originated in the pulmonary artery. A 38-year-old man was urgently hospitalized with dyspnea and back pain. He had been on hemodialysis for 2 years due to chronic renal failure. Read More

Braz J Otorhinolaryngol 2018 Apr 17. Epub 2018 Apr 17.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

Introduction: Reactive hyperplastic lesions develop in response to a chronic injury simulating an exuberant tissue repair response. They represent some of the most common oral lesions including inflammatory fibrous hyperplasia, oral pyogenic granuloma, giant cell fibroma, peripheral ossifying fibroma, and peripheral giant cell lesions.

Objective: The incidence of those lesions was investigated in an oral pathology service, and the clinical characteristics, associated etiological factors, concordance between the clinical and histopathological diagnostic was determined. Read More

Plast Reconstr Surg 2018 May;141(5):709e-717e

Boston, Mass. From the Department of Plastic and Oral Surgery, Children's Hospital Boston, Harvard Medical School.

Background: Vascular anomalies currently are classified according to their clinical and histological characteristics. Recent advances in molecular genetics have enabled the identification of somatic mutations in most types of vascular anomalies. The purpose of this study was to collate information regarding the genetic basis of vascular anomalies. Read More

Am J Dermatopathol 2018 Apr 24. Epub 2018 Apr 24.

Department of Dermatology, Bahçeşehir University Medical Faculty, Istanbul, Turkey.

The orf virus, a member of poxvirus family, is a zoonotic parapoxvirus endemic in many countries, mostly seen among sheep, goats, oxen, and may be transmitted to humans. Orf virus infections may induce ulceration, papulonodular, pustular, or ecthyma lesions in the skin. Rarely, orf virus provokes extensive vasculoendothelial proliferation by encoding an apparent homolog of the mammalian vascular endothelial growth factor family of molecules. Read More

Med Oral Patol Oral Cir Bucal 2018 May 1;23(3):e320-e325. Epub 2018 May 1.

41 Amyclon Str, 11142 Lamprini, Athens, Greece,

Background: To describe the incidence, demographic and clinical features of 1187 localized gingival enlargements.

Material And Methods: 1187 cases of localized gingival enlargements diagnosed during a 20-year period were retrospectively collected. The patients' gender and age, as well as the main clinical features of the tumors were retrieved from the biopsy report forms. Read More

J Audiol Otol 2018 Apr 17. Epub 2018 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University Medical Center, Eulji University School of Medicine, Daejeon, Korea.

A pyogenic granuloma is one of the most common benign tumors in the head and neck. However, it rarely occurs in the external auditory canal (EAC). We report a case of a pyogenic granuloma that involved the both EAC in a pregnant woman. Read More

Clin Case Rep 2018 Apr 27;6(4):690-693. Epub 2018 Feb 27.

Department of PathologyChitwan Medical College Teaching HospitalP.O. Box 42, Bharatpur 10ChitwanNepal.

Pyogenic granuloma is a benign vascular neoplasm of the oral cavity that usually presents as a small nodular lesion, the gingiva being the commonest site. Occasionally it occurs at uncommon sites with unusual sizes. Here we describe two cases of oral pyogenic granulomas that had an unusual presentation. Read More

Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.

Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp); São José dos Campos, SP, Brazil.

Intravascular papillary endothelial hyperplasia (IPEH) is an unusual benign, non-neoplastic vascular lesion that usually occurs in skin, but is uncommon in the oral cavity. Herein, we review the pertinent literature of oraiiPEH and report a new mixed form. A 61-year- old man presented with an ulcerated nodule in the lingual portion of the gingiva related to the left mandibular canine. Read More

Medicine (Baltimore) 2018 Mar;97(13):e9934

Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo.

Rationale: Oral metastases occur more commonly in bone, but can also manifest in soft tissues and eventually resemble a reactive lesion. Few cases of oral metastases mimicking reactive lesions in soft tissues have been reported to date.

Patient Concerns: We report a metastasis of gastric carcinoma (GC) to the oral mucosa without bone involvement in a 43 yom clinically and microscopically mimicking a reactive lesion. Read More

Pediatr Dermatol 2018 Mar;35(2):237-238

Am J Dermatopathol 2018 Apr;40(4):231-239

Professor, Department of Dermatology, Mayo Clinic, Rochester, MN.

Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. Read More

J Obstet Gynaecol 2018 Mar 21:1-3. Epub 2018 Mar 21.

a Faculty of Dentistry , University of British Columbia , Vancouver , Canada.

Indian J Dermatol Venereol Leprol 2018 Mar 16. Epub 2018 Mar 16.

Department of Surgery, VMMC, Safdarjung Hospital, New Delhi, India.

Urol Case Rep 2018 May 17;18:1-2. Epub 2018 Feb 17.

Royal Liverpool & Broadgreen NHS Trust, Prescot Road, Liverpool, United Kingdom.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S102-S107

Division of Oral and Maxillofacial Pathology, Columbia University Medical Center, New York, USA.

Tumor metastasis to the oral cavity is rare and is usually an indication of late-stage disease and poor prognosis. While, there are reports of renal cell carcinoma (RCC) metastatic to oral cavity, vast majority of them are to the jaw. Herein, we present a case of a 78-year-old woman with RCC metastasis limited to the oral soft tissue without any bone involvement. Read More

Radiol Case Rep 2018 Feb 23;13(1):248-253. Epub 2017 Dec 23.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1405 Clifton Rd NE, Atlanta, GA 30322 USA.

A 4-year-old girl presented repeatedly with a complicated occipital mass, which was erroneously treated as a pyogenic granuloma. Imaging performed before a planned surgical resection detected an underlying intraoccipital dermoid with a sinus tract to the skin surface and extension into the posterior fossa. This case highlights the value of high-resolution computed tomography imaging for depiction of anatomic details and the value of magnetic resonance imaging for differential diagnosis and surgical management. Read More

Open Access Maced J Med Sci 2018 Jan 30;6(1):52-54. Epub 2017 Dec 30.

Medical Institute of the Ministry of Interior, Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.

Background: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy. Read More

J Indian Soc Periodontol 2017 Jul-Aug;21(4):258-263

Department of Oral and Maxillofacial Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.

Objective: This study reviews, analyzes, and compares the demographic data, histopathological features and discusses the treatment and prognosis of reactive lesions (RLs).

Materials And Methods: Retrospective study was performed on the departmental archives from July 2006 to July 2016 (total 5000 cases) comprising of 659 cases of RLs of the oral cavity. The recorded data included age, gender, size, site, duration, habits, etiology, histopathological diagnosis, treatment, and prognosis. Read More

J Dermatol 2018 Feb 14. Epub 2018 Feb 14.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Asian Cardiovasc Thorac Ann 2018 Mar 14;26(3):224-226. Epub 2018 Feb 14.

1 Thoracic Surgery Unit, University Hospital Careggi, Florence, Italy.

We report a case of intravenous lobular capillary hemangioma in the subclavian vein, causing venous thoracic outlet syndrome. A 32-year-old woman was referred to our unit with facial and left arm oedema. Ultrasound evaluation, computed tomography and magnetic resonance imaging showed a hypervascular mass in the middle portion of the subclavian vein, with arrest of venous flow. Read More

Indian J Dent Res 2018 Jan-Feb;29(1):61-66

Department of Community Dentistry, MIDSR Dental College, Latur, India.

Context: The reactive lesions are relatively common in the oral cavity because of the frequency with which the tissues are injured. They often result from a known stimulus or injury such as dental plaque, calculus, or foreign material.

Aims: : The aim of this study was to review the clinicopathologic features of reactive hyperplastic lesions (RHLs) of the oral cavity at MIDSR, Dental College and Hospital, Latur, Maharashtra, and to compare these data with those of previously reported studies. Read More

J Indian Soc Periodontol 2017 May-Jun;21(3):241-244

Department of Periodontology, Dayananda Sagar College of Dental Sciences, Bengaluru, Karnataka, India.

Pyogenic granuloma (PG) is a nonneoplastic, tumor-like growth commonly seen in the oral mucosa or skin. Although nonpathological, its existence might lead to complications such as secondary infections or diastema formation. Hence, surgical removal of the growth seems mandatory. Read More

Support Care Cancer 2018 May 10;26(5):1353-1355. Epub 2018 Feb 10.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.

J Invest Dermatol 2018 Feb 8. Epub 2018 Feb 8.

Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:

We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model; Microsoft Research Asia, Beijing, China) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (19,398 images in total). The trained model was validated with the testing portion of the Asan, Hallym and Edinburgh datasets. Read More

Ophthalmic Plast Reconstr Surg 2018 Feb 5. Epub 2018 Feb 5.

Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China.

Purpose: BRAF V600E mutations were recently identified in some pyogenic granulomas of skin, particularly lesions arising in patients with port wine stains. In this study, the authors analyzed BRAF gene status in 28 periocular pyogenic granulomas to determine its role in their pathogenesis.

Methods: Retrospective review of ophthalmic pathology archives from 2007 to 2016 was used to identify pyogenic granulomas of the conjunctiva, eyelid, and orbit. Read More

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):415-420

Department of Oral Pathology and Microbiology, Government Dental College, Kottayam, Kerala, India.

Hemangioendothelioma commonly occurs in the superficial or deep soft tissue of the extremities, lungs, liver, bone and lymph nodes, with oral cavity being a rare location. It is usually benign but can show variable grades of malignancy. According to the histological presentation, hemangioendothelioma has been classified as epithelioid, Kaposiform, hobnail (Dabska-Retiform), epithelioid sarcoma like and composite. Read More

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):382-386

Department of Periodontics, Post Graduate Institute of Dental Sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India.

Background And Objective: Reactive proliferations of oral cavity comprise pyogenic granuloma (PG), fibrous hyperplasia (FH), peripheral ossifying fibroma (POF), and peripheral giant-cell granuloma (PGCG). They often pose diagnostic challenges due to their overlapping clinical and histopathological features. This study was conducted to determine the frequency and clinicopathological correlation of reactive hyperplastic lesions in the oral cavity reported in our institute and compared it with other previous studies. Read More

J Indian Soc Periodontol 2017 Jan-Feb;21(1):76-79

Department of Periodontology, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, Maharashtra, India.

The aim of the present study was to assess the clinico-histopathological picture and to examine the recurrence of various localized hyperplastic gingival growths after their surgical treatment. Twenty patients of localized hyperplastic gingival outgrowth were evaluated in the present clinico-histopathological study. The data regarding age, sex, location, size, and duration of lesion were summarized. Read More

J Gastrointest Surg 2018 Jan 26. Epub 2018 Jan 26.

Department of Gastroenterology, Francisco Gentil Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal.

Pyogenic granuloma is a benign vascular lesion, uncommon in the gastrointestinal tract, and extremely rare in the small bowel. The diagnosis can be challenging prior to surgery, because of its unusual endoscopic appearance.We present a case of pyogenic granuloma of the jejunum diagnosed by capsule endoscopy and double-balloon enteroscopy and successfully managed by surgical resection. Read More

JAAPA 2018 Feb;31(2):27-29

At Stony Brook (N.Y.) University Hospital, Joseph Said is an orthopedic surgery resident, Syed T. Hoda is a pathologist, and Samantha Muhlrad is a clinical assistant professor of orthopedic surgery. The authors have disclosed no potential conflicts of interest, financial or otherwise.

This article describes a patient whose cutaneous pyogenic granuloma was mistaken for infection after injury from a fractured smartphone screen. Clinicians should suspect pyogenic granuloma in patients with these types of injuries so that patients can avoid unnecessary procedures, antibiotics, and discomfort. Read More

J Am Acad Dermatol 2018 Jun 12;78(6):e143-e144. Epub 2018 Jan 12.

Department of Dermatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address:

Contemp Clin Dent 2017 Oct-Dec;8(4):667-671

Department of Periodontics, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Localized gingival overgrowths are commonly encountered in our day-to-day clinical practice and often present a diagnostic dilemma to the clinicians. These lesions vary depending on the location, site, extent, histology, and/or etiopathology. Although most of the localized gingival enlargements represent the reactive lesion to plaque accumulation, the differential diagnosis ranges from peripheral fibroma to pyogenic granuloma to peripheral fibroma with ossification and/or calcification, peripheral giant cell granuloma, etc. Read More

Eur J Breast Health 2018 Jan 1;14(1):29-34. Epub 2018 Jan 1.

Department of Radiology, Taksim Gaziosmanpaşa Training and Research Hospital, İstanbul, Turkey.

Objective: The purpose of this study is to present mammography and ultrasound findings of male breast lesions and to investigate the ability of diagnostic modalities in estimating the evolution of gynecomastia.

Materials And Methods: Sixty-nine male patients who admitted to Taksim and Bakirkoy Education and Research Hospitals and underwent mammography (MG) and ultrasonography (US) imaging were retrospectively evaluated. Duration of symptoms and mammographic types of gynecomastia according to Appelbaum's classifications were evaluated, besides the sonographic findings in mammographic types of gynecomastia. Read More

J Am Acad Dermatol 2018 Jun 4;78(6):e141-e142. Epub 2018 Jan 4.

Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. Electronic address:

Pediatr Dermatol 2018 Jan 20;35(1):117-120. Epub 2017 Dec 20.

Section of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Saint Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Background: Pyogenic granuloma (PG) is a common, acquired, benign vascular neoplasm of the skin and mucous membranes. It occurs most often in children and adolescents. First-line treatment options for PG are based on destructive approaches. Read More