J Assoc Physicians India 2017 Aug;65(8):14-17

Assistant Professor, Microbiology, JNUIMSRC, Jaipur, Rajasthan.

Introduction: There are conflicting reports in literature about correlation of CSF viral RNA levels with neurological manifestations in HIV positive patients. Many studies in animals and human subjects have shown that CSF HIV-1 RNA can be useful as a specific marker of HIV induced neuropathology. To the contrary there are studies which show that neurological disease states can occur in absence of significant increase of CSF HIV RNA. Read More

Open Access Maced J Med Sci 2017 Jul 13;5(4):423-426. Epub 2017 Jul 13.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, and Onkoderma-Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.

Pyogenic granuloma is a common benign vascular tumour occurring in all ages. Both skin and mucous membranes can be affected. Of pathogenetic importance are trauma, BRAF mutations and probably herpes virus type 1, Orf virus and/or human papilloma virus type 2. Read More

Pediatr Radiol 2017 Aug 4;47(9):1184-1195. Epub 2017 Aug 4.

Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.

Sonography can be used in the management of pediatric soft-tissue vascular anomalies for diagnosing, for assessing lesion extent and for evaluating complications and response to therapy. The sonographic technique includes a combination of gray-scale imaging with color and spectral Doppler techniques. However the interpretation of the sonographic findings requires correlation with the clinical findings, some of which can be easily obtained at the time of scanning. Read More

Graefes Arch Clin Exp Ophthalmol 2017 Jul 24. Epub 2017 Jul 24.

Department of Ophthalmology, University Eye Hospital Bonn, University of Bonn, Ernst-Abbe Str. 2, 53127, Bonn, Germany.

Purpose: The purpose of the study was to evaluate the characteristics of sebaceous gland carcinoma (SGC) of the ocular adnexae, which is due to a high variability in clinical, histological and immunohistochemical characteristics often challenging to diagnose.

Methods: Records of six patients with SGC were reviewed, who underwent surgical excision and who were histologically diagnosed with SGC. For comparison, there were specimens from four patients with basal cell carcinoma (BCC) and four patients with squamous cell carcinoma (SCC). Read More

Saudi Dent J 2017 Jul 3;29(3):129-134. Epub 2017 May 3.

Maxillofacial Surgery and Diagnostic Sciences Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi Arabia.

Kaposi Sarcoma (KS) is an intermediate neoplasm affecting the endothelial cells of mucous membranes and skin. It arises most commonly among HIV-infected individuals. We present an intra-oral KS in an 80-year-old Saudi male patient, who is HIV-seronegative, non-immunosuppressed, and with no history of organ transplantation. Read More

Orbit 2017 Jul 19:1-6. Epub 2017 Jul 19.

g Corneoplastic Unit, Queen Victoria Hospital , East Grinstead , United Kingdom.

We report our experience with pediatric endonasal dacryocystorhinostomy (DCR). Multicenter, retrospective, noncomparative study. Cases of pediatric endonasal DCR during 2006-2011 were included from six oculoplastic units. Read More

Ear Nose Throat J 2017 Jul;96(7):240

Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, CA, USA.

Clin Exp Dermatol 2017 Jul 10. Epub 2017 Jul 10.

Department of Dermatology, Kyungpook National University School of Medicine, 130, Dongduk-ro, Jung-gu, Daegu, 41944, Korea.

Australas J Dermatol 2017 Jun 30. Epub 2017 Jun 30.

Department of Dermatology, College of Medicine, Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.

J Clin Diagn Res 2017 May 1;11(5):ZC25-ZC28. Epub 2017 May 1.

Postgraduate Student, Department of Oral Pathology, St. Joseph Dental College, Eluru, Andhra Pradesh, India.

Introduction: Angiogenesis is vital in the aetiology and pathogenesis of a number of pathological processes that include solid reactive lesions like pyogenic granuloma and chronic inflammatory disorders like periapical granuloma. Vascular Endothelial Growth Factor (VEGF) is a potent proangiogenic cytokine secreted by many cell types which present several pivotal functions in physiologic and pathologic angiogenesis.

Aim: The aim of the present study was to evaluate and compare the expression of VEGF in oral Pyogenic Granuloma (PG) and Periapical Granuloma (PAG) and also to correlate with the inflammatory cell infiltrate. Read More

Indian J Plast Surg 2017 Jan-Apr;50(1):104-106

Department of Plastic and Reconstructive Surgery, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Malignant melanoma is a potentially lethal cutaneous malignancy. Melanoma in paediatrics is rare as compared to adult melanoma. The clinicopathological characteristics of paediatric melanoma are different from adult melanoma, and the presence of melanoma mimics which occurs frequently in children (Spitz naevi) resulted in diagnosis uncertainty. Read More

Skin Appendage Disord 2017 May 16;3(2):67-69. Epub 2017 Feb 16.

Department of Dermatology, Ankara Numune Research and Education Hospital, Ankara, Turkey.

J Eur Acad Dermatol Venereol 2017 May 30. Epub 2017 May 30.

Department of Dermatology, Tel-Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 6423906, Israel.

Hum Pathol 2017 May 26. Epub 2017 May 26.

Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine -, Chicago, IL.

Renal vascular lesions (RVL) are rare and their morphological spectrum remains largely unknown, particularly in children. In this study, we characterize the clinicopathological features of RVL in a cohort of twelve children. Seven lesions were classified as previously recognized entities: vascular malformations (four), papillary endothelial hyperplasia (two), and pyogenic granuloma (lobular capillary hemangioma) (one). Read More

Stomatologiia (Mosk) 2017;96(2):33-35

Peoples' Friendship University of Russia, Moscow, Russia.

The paper presents an example of differential diagnostic studies for pyogenic granuloma and oral squamous cell carcinoma (SCC). In the described case immunohistochemistry with antibodies to Ki-67 and Gli1 was used as conventional histological procedure proved to be inconvenient for adequate diagnostics. The immunohistochemical study established increased proliferative activity of epithelial cells specific both pyogenic granuloma and oral SCC, but intensive Gli1 protein expression in membranes and cytoplasm of epithelial cells with malignant transformation allowed differentiation of these neoplasms. Read More

Glob Pediatr Health 2017 25;4:2333794X17704607. Epub 2017 Apr 25.

Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX, USA.

J Craniofac Surg 2017 Jun;28(4):e398-e399

*Department of Pathology, Faculty of Medicine †Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep ‡Department of Pathology, Faculty of Medicine, TOBB Economics and Technology, Ankara, Turkey.

Metastatic tumors rarely occur in the oral cavity. The most common of the oral metastases are lung cancers in males, and breast and genital cancers in females. The most common primary tumor metastasis to the oral cavity is from the lung, kidney, liver, prostate, and colorectal cancers. Read More

J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):180

Department of Oral and Maxillofacial Pathology, Navodaya Dental College, Raichur, Karnataka, India.

Background: In the literature, many studies were attempted to analyze the distribution of oral reactive lesions in terms of age, gender and location. However, very few studies have focused on the detailed histopathological features of these reactive lesions of oral cavity. Thus, the purpose of this paper is to document the occurrence, distribution and various histopathological features of reactive gingival lesions. Read More

J Dermatol 2017 May 2. Epub 2017 May 2.

Horiguchi Clinic of Dermatology, Hirakata, Japan.

N Engl J Med 2017 Apr;376(17):1667

Lions Eye Institute, Perth, WA, Australia

Dermatol Surg 2017 Apr 19. Epub 2017 Apr 19.

*University of Texas McGovern Medical School at Houston, Houston, Texas; †Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, Texas.

Background: Sodium tetradecyl sulfate (STS) is Food and Drug Administration approved for treatment of varicose veins, but numerous other off-label applications have been reported.

Objective: To describe the clinical uses of STS, as well as efficacy and adverse effects.

Methods: Review of studies searchable on PubMed from 1938 to 2016 describing clinical uses of STS to determine efficacy and adverse effects associated with various applications. Read More

Curr Urol 2017 Jan 10;9(4):216-218. Epub 2016 Dec 10.

Urology, The Whittington Hospital NHS Trust, London, UK.

We present the case of a 37-year-old man who presented with a penile lesion that engorged on erection. Ultrasound examination demonstrated vascularity of the lesion and the decision was made to perform a complete excision. Histological analysis confirmed the diagnosis of a pyogenic granuloma of the penis. Read More

Saudi Med J 2017 Apr;38(4):405-412

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia. E-mail.

Objectives: To report the prevalence and types of biopsied oral and maxillofacial lesions (OMLs) in South-Western (Jazan Province) region, , Kingdom of Saudi Arabia (KSA). Methods: This retrospective study was based on the retrieval of clinicopathological data for a period of 6 years between January 2009 and December 2014. These  data were obtained between October 2014 and June 2015 from the histopathology records of King Fahad Central Hospital, Jazan, KSA, which is the only referral center for biopsy services. Read More

Orbit 2017 Apr 28;36(2):122-123. Epub 2017 Feb 28.

d Lions Eye Institute , Perth , Australia.

A 68-year-old gentleman presented with a lesion that resembled a pyogenic granuloma in his inferior fornix. The lesion was excised and biopsy demonstrated a proliferation of malignant spindle cells. Three weeks following initial excision, the lesion recurred and was removed via wedge excision of the eyelid. Read More

Clin Gastroenterol Hepatol 2017 Mar 27. Epub 2017 Mar 27.

Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng, China.

Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.

Department of Medicine, University of California San Diego, La Jolla, California.

Background: Bullous impetigo is a superficial skininfection caused by Staphylococcus aureus (S.aureus). Pyogenic granuloma is a common benigntumor frequently associated with prior trauma. Read More

J Neurol Surg Rep 2017 Jan;78(1):e59-e61

Department of Neurosurgery, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.

Background Lobular capillary hemangioma is a rare benign tumor, most frequently located in the head or neck region, the nasal cavity being uncommonly affected. Its etiopathogenesis is not fully established, although traumatic and hormonal factors have been implied. Case Description A 50-year-old female patient underwent an uneventful endoscopic transsphenoidal removal of a pituitary cystic macroadenoma at our institution. Read More

Pediatr Dermatol 2017 May 20;34(3):e126-e127. Epub 2017 Mar 20.

Department of Dermatology, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

Fibro-osseous pseudotumor of the digits is a benign neoplasm that originates in the soft tissue adjacent to the short bones of the hands and feet. We present a case in a 13-year-old girl that was initially misdiagnosed as pyogenic granuloma. Familiarity with this entity and imaging and histologic studies are necessary to avoid incorrect diagnoses and aggressive surgical interventions. Read More

J Coll Physicians Surg Pak 2017 Mar;27(3):S28-S29

Department of Oral and Maxillofacial Pathology, NIMS Dental College, Jaipur, India.

Odontogenic myxomas are rare odontogenic tumors of jaw characterised by accumulation of mucoid ground substance with little collagen. Peripheral odontogenic myxoma (POM) is extra-osseous variant of odontogenic myxomas, occurring solely in the soft tissue covering the tooth bearing portion of jaws. POM is exceedingly rare, less than 10 cases have been published till date. Read More

JAMA Ophthalmol 2017 Apr;135(4):383-385

Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts4Department of Ophthalmology, Massachusetts Eye and Ear, Boston5Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

Importance: Pyogenic granulomas, acquired vascular lesions, form on the ocular or palpebral surface related to inflammation from chalazia, trauma, or surgery. They can be unsightly, spontaneously bleed, and cause irritation to patients.

Observations: A case series is presented of 4 consecutive children with acquired ocular surface pyogenic granulomas treated at Boston Children's Hospital from 2014 to 2016 with only topical timolol, 0. Read More

J Cutan Pathol 2017 Jun 23;44(6):516-522. Epub 2017 Mar 23.

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Pyogenic granulomas are benign, reactive, typically superficial vascular lesions that can be idiopathic or arise secondary to trauma, underlying vascular malformations, infections, physiologic or pathologic endocrine changes, and hormone therapy. Deep-seated/subcutaneous pyogenic granulomas (DSPG) are rarely seen in any age group. Pediatric DSPGs can be a clinical and pathologic challenge because these lesions mimic other vascular lesions, including kaposiform hemangioendothelioma, infantile hemangiomas and vascular malformations. Read More

Urology 2017 Jun 14;104:191-193. Epub 2017 Feb 14.

Department of Surgery, Division of Urology, Rambam Health Care Campus, Haifa, Israel.

Pyogenic granuloma (PG) is a benign, vascular tumor that is rarely reported in the urinary tract of pediatric population. Herein we present a case of a child followed up for recurrent painless macroscopic hematuria. We performed ureteroscopy, and a whitish lesion was discovered in the upper calyx of the right kidney. Read More

Hautarzt 2017 Mar;68(3):181-186

Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgien.

This review on herpes simplex virus type I and type II (HSV-I, HSV-II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV-I infection; HSV-related folliculitis; verrucous HSV-I and HSV-II lesions; the role of recurrent HSV-I infection in burning mouth syndrome; HSV-I and HSV-II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV-I or HSV-II are discussed. The usual antiviral treatment regimens for primary and recurrent orolabial and genital herpes are compared to short-term and one-day treatment options. Read More

Hautarzt 2017 Feb 14. Epub 2017 Feb 14.

Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.

This review on herpes simplex virus type I and type II (HSV‑I, HSV‑II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV‑I infection; HSV-related folliculitis; verrucous HSV‑I and HSV‑II lesions; the role of recurrent HSV‑I infection in burning mouth syndrome; HSV‑I and HSV‑II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV‑I or HSV‑II are discussed. The usual antiviral treatment regimens for primary and recurrent orolabial and genital herpes are compared to short-term and one-day treatment options. Read More

Rev Esp Enferm Dig 2017 Feb;109(2):152-154

Endoscopy Unit. Gastroenterology Department. , Hospital Clinic, Barcelona, España.

Pyogenic granuloma is a non-infectious and non-granulomatous lesion. Its location in the small bowel is very rare. We present a 46 year-old woman with a chronic liver disorder that had a severe chronic anemia with occult blood losses. Read More

J Plast Reconstr Aesthet Surg 2017 Apr 9;70(4):487-494. Epub 2017 Jan 9.

Department of Hand Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

Introduction: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 questionnaire.

Methods: In total, 304 patients who underwent surgery for benign bone and soft tissue tumors of the upper limb were included. Tumors were classified into three size groups: <1 cm, 1-3 cm, and >3 cm. Read More

Case Rep Obstet Gynecol 2016 29;2016:3435270. Epub 2016 Dec 29.

Department of Pathologic Anatomy, Dr. Nélio Mendonça Hospital, Av. Luís de Camões, Funchal, 9004-514 Madeira Island, Portugal.

Lobular capillary hemangioma, or pyogenic granuloma, is an acquired hemorrhagic benign vascular lesion of the skin and mucous membranes. The pyogenic granuloma of the vulva is a rare finding and a limited number of case reports are available in the literature. To the best of our knowledge this is the first case described as a single pyogenic granuloma on the vulva. Read More

Clin Nucl Med 2017 Apr;42(4):e214-e215

From the Departments of *Nuclear Medicine & PET Centre, and †Pathology, Aarhus University Hospital, Aarhus, Denmark.

We present a case of a subcutaneous process in the abdominal wall with high prostate-specific membrane antigen (PSMA) activity on Ga-PSMA PET/CT. Histology demonstrated a benign lobular capillary hemangioma with a high vascular density, with highly PSMA-positive endothelial cells. It is well known that PSMA is expressed in different tissue, including neovasculature in various malignant tumors, and the knowledge is rapidly evolving as new discoveries appear. Read More

J Cutan Pathol 2017 May 16;44(5):451-455. Epub 2017 Feb 16.

School of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.

Background: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In this study, vascular lesions occurring in the lips were retrieved from an Oral Pathology Service.

Methods: Among 5600 biopsies, 131 cases were found. Read More

J Dent Res Dent Clin Dent Prospects 2016 21;10(4):241-246. Epub 2016 Dec 21.

Postgraduate Student, Biotechnology Research Center and Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background. Reliable immunohistochemical assays to assess the definitive role of mast cells (MCs) and angiogenesis in the pathogenesis of oral reactive lesions are generally not available. The aim of the present study was to evaluate mast cell counts (MCC) and microvessel density (MVD) in oral reactive lesions and determine the correlation between MCC and MVD. Read More

J Obstet Gynaecol Res 2017 Jan;43(1):16-22

Clinica Odontologica, Federal University of Maranhao, São Luís, Brazil.

The aims of this literature review are: to depict the main oral diseases that are related to pregnancy; to clarify some of the possible systemic mechanisms that are associated with these changes; and to address issues about oral care during pregnancy. A woman's organs undergo various physiological, neurological, and hormonal changes during pregnancy. Such changes occur gradually and are essential for the development of the fetus, providing what is needed for tissue formation and establishment of reserves for uterine and fetal life. Read More

J Obstet Gynaecol 2017 May 26;37(4):537-538. Epub 2016 Dec 26.

a Department of Otolaryngology, Department of Clinical Sciences and Community Health , Fondazione I.R.C.C.S. Ca' Granda, Ospedale Maggiore Policlinico, University of Milan , Milan , Italy.

Mycopathologia 2017 Jun 21;182(5-6):549-554. Epub 2016 Dec 21.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Infections caused by Trichophyton rubrum are very common in dermatological disease. It most often appears as superficial cutaneous mycosis, such as tinea manuum, tinea pedis, and tinea corporis. However, deep infection caused by T. Read More

J Craniofac Surg 2017 Mar;28(2):577-578

Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista-UNESP, Araçatuba, Brazil Department of Prostodonthics, Hospital for Rehabilitation of Craniofacial Anomalies-HRAC, Bauru, Brazil Department of Stomatology, Bauru Dental School, São Paulo University-USP, Bauru, Brazil.

Indian Dermatol Online J 2016 Nov-Dec;7(6):526-528

Department of Dermatology, Venereology and Leprosy, IGMC, Shimla, Himachal Pradesh, India.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) forms 9% of the cutaneous T-cell lymphomas. It usually presents as solitary reddish brown ulcerating nodule or indurated plaque. Sometimes, it mimics other dermatological diseases such as eczema, pyoderma gangrenosum, pyogenic granuloma, morphea, and squamous cell carcinoma. Read More

Braz Dent J 2016 Oct-Dec;27(6):781-786

Department of Bioscience and Oral Diagnosis, São Paulo State University (UNESP), Institute of Science and Technology, São José dos Campos, SP, Brazil.

Adenosquamous carcinoma is an aggressive variant of squamous cell carcinoma. This report describes a case of adenosquamous carcinoma with clinical features of a benign lesion and discusses the differential diagnoses, especially regarding histopathological and immunohistochemical analyses. A 45-year-old male was referred to our outpatient clinic complaining about a rapid-growing enlargement in hard palate. Read More

JAAD Case Rep 2016 Nov 5;2(6):454-456. Epub 2016 Dec 5.

Department of Dermatology, Rush University, Chicago, Illinois.

JAAD Case Rep 2016 Nov 4;2(6):430-432. Epub 2016 Dec 4.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.