Search Our Scientific Publications & Authors

Medicine (Baltimore) 2018 Nov;97(48):e13415

Department of Colorectal Surgery, Ningbo No.2 Hospital, No.41 Northwest Street, Ningbo, Zhejiang Province, China.

Rationale: Pyoderma gangrenosum (PG) is a rare postoperative complication of enterostomy, mostly developing from dermatitis, which may have serious consequence.

Patient Concerns: A patient with lower rectal cancer receiving low anterior resection (LAR) and protective ileostomy was initially diagnosed with dermatitis, which very quickly developed to PG, though no medical or familial history was found.

Diagnosis: We diagnosed the patient with peristoaml dermatitis starting from a tiny skin ulceration, but corrected the diagnosis to PG because of the rapid development and severe consequences. Read More

Gastroenterol Hepatol 2018 Nov 20. Epub 2018 Nov 20.

Servicio de Aparato Digestivo, Hospital Universitario Miguel Servet, Zaragoza, España.

J Gastroenterol Hepatol 2018 Nov 22. Epub 2018 Nov 22.

Department of Gastroenterology, Academic Hospital Roeselare, Roeselare, Belgium.

Hautarzt 2018 Nov 22. Epub 2018 Nov 22.

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Rostock, Rostock, Deutschland.

Background: The PAPA syndrome, an acronym for pyogenic sterile arthritis, pyoderma gangraenosum and acne, is an autosomal dominant hereditary disease which is caused by a mutation in the PSTPIP1 ("proline-serine-threonine phosphatase interacting protein 1") gene located on chromosome 15 and encodes the proline-serine-threonine phosphatase-interacting protein 1. An association with Crohn's disease (CD), autoimmune diseases of the liver and PAPA syndrome has not yet been reported in the literature.

Objective: To thoroughly investigate a family with three affected members (mother and 2 children) with newly diagnosed PAPA syndrome and intestinal and hepatobiliary symptoms. Read More

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Department of Pathology, University of Washington, Seattle, WA.

In the United States, chronic ulcers affect 6.5 million people, with a cost of ≈$20 million annually. The most common etiology of chronic ulcers in the United States is venous stasis, followed by arterial insufficiency and neuropathic ulcers. Read More

Int J Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.

Clin Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan.

Acta Orthop Belg 2018 Mar;84(1):17-24

Pyoderma gangrenosum and necrotizing fasciitis are two rare pathologic entities with a similar clinical image, but a who require a very different management. In general physicians, orthopedics, dermatologists, plastic surgeons will hardly ever see it, but when they do it is very important to distinguish between both. In this paper with the focus on the practical approach ,we expose the diagnostic pitfalls in the differential diagnosis, explain how to prevent them and summarize the evidence on therapeutic management. Read More

JAAD Case Rep 2018 Nov 10;4(10):1027-1029. Epub 2018 Nov 10.

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.

Am Surg 2018 Mar;84(3):e112-e113

Department of Dermatology, Universitaetsklinikum Muenster, Muenster, Germany.

J Oral Maxillofac Surg 2018 Oct 24. Epub 2018 Oct 24.

Private Practice, Cosmetic Facial Surgery, Midlothian, VA. Electronic address:

Purpose: Pyoderma gangrenosum (PG) is an uncommon autoimmune, neutrophilic, ulcerative skin condition of uncertain etiology believed to result from dysregulation of the immune system. Although this entity is well recognized by dermatologists, other specialists are less familiar with diagnosis and treatment. This report describes a severe PG reaction to an elective cosmetic facelift, which is believed to be the second reported case of PG after facelift surgery. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

Pyoderma gangrenosum is a painful ulcerating disease. The current evidence base for treatment is limited. In a large prospective study of topical treatments, 44% of patients were healed by 6 months. Read More

Dtsch Med Wochenschr 2018 Nov 15;143(23):1682-1689. Epub 2018 Nov 15.

Evaluation of skin diseases can be challenging for non-dermatologists. Even obvious well-characterized skin pathologies might be misleading and thus treatment can fail. Particularly the differentiation of surgical treated entities is important, for example the management of a wound healing disturbance profoundly differs from that of a pyoderma gangrenosum. Read More

JBJS Case Connect 2018 Nov 14. Epub 2018 Nov 14.

Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Case: A 51-year-old woman with diabetes developed wound complications consistent with presumed infection 5 days after undergoing a carpal tunnel release. Despite multiple debridements, the wounds continued to necrose and deteriorate. A diagnosis of pyoderma gangrenosum eventually was made, and the condition improved with the administration of systemic corticosteroids. Read More

Isr Med Assoc J 2018 Nov;20(11):712-713

Department of Medicine A, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.

World J Clin Cases 2018 Nov;6(13):703-706

Cerebrovascular Disease Center, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.

Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune diseases. However, PG rarely shows visceral involvement, especially in the kidney. A 20-year-old female presented with pedal edema and skin ulceration of both lower limbs. Read More

G Ital Dermatol Venereol 2018 Nov 9. Epub 2018 Nov 9.

Department of Dermatology, R. D. Gardi Medical College, Ujjain, India -

J Surg Case Rep 2018 Nov 5;2018(11):rjy299. Epub 2018 Nov 5.

Medical Oncology, St John of God Subiaco Hospital, Subiaco, Western Australia.

Pyoderma gangrenosum is a rare, serious and commonly missed condition that can effect post-operative surgical patients. The condition is commonly misdiagnosed as a wound infection, with subsequent inappropriate antibiotic therapy and wound debridement. We present the case of a 46-year-old patient who suffered this delayed diagnosis and multiple unnecessary interventions. Read More

JAAD Case Rep 2018 Nov 29;4(10):979-981. Epub 2018 Oct 29.

Schulich School of Medicine and Dentistry, London, Canada.

Clin Gastroenterol Hepatol 2018 Nov 4. Epub 2018 Nov 4.

Multidisciplinary Center for Inflammatory Bowel Disease, University of North Carolina, Chapel Hill, NC; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC. Electronic address:

Acta Derm Venereol 2018 Nov 5. Epub 2018 Nov 5.

Department of Dermatology and Allergy Centre, Odense University Hopsital, DK-5000 Odense, Denmark.

JAMA Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, University of California San Francisco, San Francisco.

Importance: Pyoderma gangrenosum and necrotizing Sweet syndrome are diagnostically challenging variants of neutrophilic dermatosis that can clinically mimic the cutaneous and systemic features of necrotizing fasciitis. Improved characterization of these rare variants is needed, as improper diagnosis may lead to inappropriate or delayed treatment and the potential for morbidity.

Objective: To determine the characteristics of necrotizing neutrophilic dermatosis to improve diagnostic accuracy and distinguish from infection. Read More

J Drugs Dermatol 2018 Oct;17(10):1058-1060

Introduction: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis commonly treated with steroid immunosuppression. The utility of dapsone as a non-immunosuppressive treatment for PG has been reported in case reports and series. We sought to evaluate the response and tolerability of concurrent systemic dapsone therapy for treating PG. Read More

Br J Dermatol 2018 Oct 26. Epub 2018 Oct 26.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

J Trauma Acute Care Surg 2018 Oct 23. Epub 2018 Oct 23.

Department of Dermatology, Oregon Health & Science University, Portland, OR, USA.

Pyoderma Gangrenosum (PG) is a rare, ulcerative cutaneous disorder typically affecting the lower extremities. The clinical appearance of PG can mimic various cutaneous infections and neoplasms, leading to misdiagnosis and mistreatment including unnecessary surgical interventions such as debridements and even amputations. Diagnostic criteria exist, including characteristic clinical appearance and the exclusion of other diagnoses, however no definitive test exists to confirm the diagnosis of PG. Read More

Int J Dermatol 2018 Oct 21. Epub 2018 Oct 21.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

Pan Afr Med J 2018 5;30:95. Epub 2018 Jun 5.

University Mohammed V, Ibn Sina, Hospital University, Rabat, Morocco.

Ecthyma gangrenosum (EG) is a severe potentially lethal cutaneous infection that progresses sequentially from maculopapular rash to haemorrhagic bulla and then to necrotic ulceration with surrounding erythema. It usually occurs in immunocompromised patients (aplasia secondary to chemotherapy, HIV infection, neutropenia or functional deficit of neutrophils, agammaglobulinemia). It rarely affects healthy people. Read More

J Am Acad Dermatol 2018 Oct 17. Epub 2018 Oct 17.

Service de dermatologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP), Université Paris Diderot, F-75010 Paris. Electronic address:

Dermatol Ther 2018 Oct 20:e12774. Epub 2018 Oct 20.

Assistance Publique- Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, Paris, France.

Non-peristomal postoperative pyoderma gangrenosum (PPG) is a rare subtype of pyoderma gangrenosum that occurs in the early postoperative period at surgical incisions, most commonly after breast surgery. Early diagnosis and treatment is essential to prevent severe scaring. TNF-alpha inhibitor infliximab was reported to be efficient in treatment of PPG refractory to systemic corticosteroids. Read More

Z Rheumatol 2018 Dec;77(10):857-859

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland.

The diagnosis of pyoderma gangraenosum was previously made as a diagnosis of exclusion. For this reason repeated attempts have been made in recent years to develop new diagnostic scores, whereby the typical clinical and anamnestic aspects were usually taken into account and the relevant differential diagnoses were excluded. With the PARACELSUS score an evaluated diagnostic score was presented for the first time. Read More

J Cutan Med Surg 2018 Nov/Dec;22(6):650-651

1 Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

J Pak Med Assoc 2018 Jul;68(7):1148-1150

Department of Dermatology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Pyoderma gangrenosum (PG) of the penis is a very rare entity in medicine and it can be destructive. Generally, pyoderma gangrenosum is known to be common among patients with systemic diseases such as inflammatory bowel diseases, polyarthritis, diverticulosis, paraproteinaemia, myeloma, leukaemia, active chronic hepatitis, and Behcet syndrome. Early diagnosis and administrating effective treatment can prevent permanent damage to the penis and save the patient's social life. Read More

JAAD Case Rep 2018 Oct 4;4(9):907-909. Epub 2018 Oct 4.

Department of Dermatology, Rush University Medical Center, Chicago, Illinois.

Clin Exp Dermatol 2018 Oct 7. Epub 2018 Oct 7.

Department ofDermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.

J Dermatol Sci 2018 Nov 15;92(2):181-187. Epub 2018 Sep 15.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama, Japan.

Background: Lympho-epithelial Kazal-type inhibitor (LEKTI) tightly controls the activities of serine proteases such as kallikrein-related peptidase (KLK) 5 and KLK7 in the epidermis. LEKTI is known to be an essential molecule for the epidermal skin barrier, as demonstrated by SPINK5 nonsense mutation, which results in Netherton syndrome. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns or damage-associated molecular patterns and produce inflammatory cytokines, chemokines, and antimicrobial peptides. Read More

Hautarzt 2018 Oct;69(Suppl 1):16-18

Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.

PLoS One 2018 27;13(9):e0204450. Epub 2018 Sep 27.

Department of Biomedical and Diagnostic Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, United States of America.

Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F (fast) components. They impair the innate immune system, the first line of defense against these pathogens. Read More

Plast Reconstr Surg Glob Open 2018 Aug 8;6(8):e1886. Epub 2018 Aug 8.

Department of Surgery, Division of Plastic Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah.

Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency characterized by impairment of leukocyte migration during an inflammatory response. LAD patients can experience recurrent neutrophilic wounds similar to pyoderma gangrenosum (PG), predominantly of the skin and mucosal surfaces. There have been only a few reports addressing the management of extensive, life-threatening wounds in LAD patients. Read More

Dermatol Ther 2018 09 25;31(5):e12697. Epub 2018 Sep 25.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

JAAD Case Rep 2018 Sep 14;4(8):797-799. Epub 2018 Sep 14.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

J Dermatolog Treat 2018 Nov 19:1-5. Epub 2018 Nov 19.

a Dermatology Unit, Department of Medical, Surgical and Experimental Sciences , University of Sassari , Sassari , Italy.

Background: Inflammatory bowel diseases (IBDs) are associated with extraintestinal manifestations including skin lesions. The intestinal microflora plays a key role in the development and course of IBD.

Aim: To examine the efficacy of probiotics and the occurrence of skin lesions in patients with IBD. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2018 09;27(3):161-163

Department of Gastroenterology, University Medical Centre Maribor, Maribor, Slovenia.

Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. Read More

Am J Med 2018 Sep 19. Epub 2018 Sep 19.

Service d'Onco-Hématologie, Institut Paoli-Calmettes, Marseille, France.

Cutis 2018 Aug;102(2):E16-E18

Dell Medical School, University of Texas Southwestern, Austin, USA.

The cutaneous manifestations of Crohn disease (CD) are varied and include pyoderma gangrenosum, erythema nodosum, and metastatic CD (MCD). The latter is defined as the occurrence of granulomatous lesions at a skin site distant from the gastrointestinal tract. Metastatic CD involving the vulva and perineum is rare and thus often is difficult to diagnose. Read More

J Dermatol 2018 Sep 19. Epub 2018 Sep 19.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

G Ital Dermatol Venereol 2018 Sep 18. Epub 2018 Sep 18.

Dermatology Unit, Department of Physiopathology and Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Pediatr Radiol 2018 Sep 17. Epub 2018 Sep 17.

Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.

Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autosomal-dominant autoinflammatory disease of incomplete penetrance and variable expression. PAPA syndrome is the result of a mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene located on chromosome 15, which results in an abnormal overproduction of the pro-inflammatory cytokine interleukin-1β (IL-1). This syndrome clinically manifests as early onset of recurrent episodes of acute aseptic inflammation of the joints, generally occurring in the first two decades of life, followed by manifestation of characteristic skin lesions in the third decade, after an obvious decline in the joint symptoms. Read More

Wounds 2018 Aug;30(8):216-223

Barry University School of Podiatric Medicine, Miami Shores, FL.

Introduction: When occurring together, pyoderma gangrenosum, severe acne, and hidradenitis suppurativa have been described as PASH syndrome. Due to the chronic autoinflammatory state existing in affected patients, PASH syndrome has been attributed to the dysregulation of wound healing.

Case Reports: Two cases are presented that demonstrate the paradigmatic clinical features of PASH syndrome and its potential link as an expanding spectrum of bacterial biofilm disorder. Read More

Eur J Gastroenterol Hepatol 2019 01;31(1):80-85

Department of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Background And Aims: Treatment of ulcerative colitis (UC) typically follows a step-up approach and targets colonic mucosal healing. Although mucosal healing reduces the risk of colectomy, whether or not early treatment of patients with 'high-risk' features using tumor necrosis factor (TNF) antagonists reduces the risk of colectomy is not clear. Accordingly, we aim to evaluate the effect of baseline treatment selection according to the risk profile on 5-year outcomes and identify predictors of poor outcomes. Read More

J Dermatol 2018 Sep 7. Epub 2018 Sep 7.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.