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J Clin Med 2021 Jan 19;10(2). Epub 2021 Jan 19.

Gastroenterology Unit, Department of Biomedical and Clinical Sciences, "L.Sacco" Hospital, 20157 Milano, Italy.

Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature on the dermatologic manifestations occurring in patients with inflammatory bowel diseases has been reviewed. Read More

World J Clin Cases 2020 Oct;8(20):4953-4957

Department of Gastroenterology and Hepatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China.

Background: Pyoderma vegetans (PV) is not a common extra-intestinal manifestation of ulcerative colitis (UC), while nasal mucosa PV associated with UC is particularly rare.

Case Summary: We report a 28-year-old female with a history of UC and pyoderma gangrenosum who presented with nasal pain. A nasal lesion could be observed in her nose, and histopathological examination was indicative of PV. Read More

Medicina (Kaunas) 2020 Aug 23;56(9). Epub 2020 Aug 23.

Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Background and Objectives Over the last years, inflammatory bowel disease (IBD) has been reported on a high incidence in pediatric populations and has been associated with numerous extraintestinal manifestations, making its management a real challenge for the pediatric gastroenterologist. Dermatological manifestations in IBD are either specific, related to the disease activity or treatment-associated, or non-specific. This literature review aims to identify and report the dermatological manifestations of IBD in children, the correlation between their appearance and the demographical characteristics, the relationship between these lesions and disease activity, and to highlight the impact of dermatological manifestations on an IBD treatment regime. Read More

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran.

Pyodermatitis-pyostomatitis vegetans is a rare inflammatory dermatosis. There is a strong association between pyodermatitis-pyostomatitis vegetans and inflammatory bowel disease, particularly ulcerative colitis. Herein, we report a case of pyodermatitis-pyostomatitis vegetans with positive direct immunofluorescence staining findings and review the literature for the past 18 years to characterize the disease, its epidemiologic characteristics, its associations, and the pathology and direct and indirect immunofluorescence findings. Read More

JAMA Dermatol 2020 03;156(3):335

Department of Dermatology, Rabta Hospital, Tunis, Tunisia.

ACG Case Rep J 2019 Aug 21;6(8):e00170. Epub 2019 Aug 21.

Department of General Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

J Dermatol 2019 09 10;46(9):e316-e317. Epub 2019 Apr 10.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

J Dtsch Dermatol Ges 2019 05 1;17(5):540-542. Epub 2019 Apr 1.

University Hospital Heidelberg, Department of Dermatology, Heidelberg, Germany.

Cutis 2019 Jan;103(1):44-45

Advanced Dermatology Associates, Ltd, Allentown, Pennsylvania, USA.

Necrobiosis lipoidica (NL) is a granulomatous inflammatory skin disease strongly associated with diabetes mellitus (DM). Red-brown papules expanding into plaques with erythematous indurated borders on the lower extremities are characteristic of NL. Diagnosis is made clinically; however, biopsy of lesions confirms the diagnosis. Read More

J Am Acad Dermatol 2020 May 21;82(5):e149-e150. Epub 2018 Oct 21.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China. Electronic address:

Postepy Dermatol Alergol 2018 Apr 24;35(2):212-216. Epub 2018 Apr 24.

Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Nicolaus Copernicus University in Torun, Faculty of Medicine in Bydgoszcz, Poland.

BMJ Case Rep 2017 Oct 13;2017. Epub 2017 Oct 13.

Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

We describe a case of disfiguring facial pyoderma vegetans in order to highlight the challenges in managing this rare skin condition and review the literature.A 54-year-old woman presented to dermatology clinic with a 3-month history of a left-sided facial lesion, which had been treated as an infected sebaceous cyst. The lesion had dramatically increased in size in the weeks prior to presentation. Read More

Int J Dermatol 2017 12 5;56(12):1457-1459. Epub 2017 May 5.

Department of Dermatology, University of Minnesota Medical School, Minneapolis, MN, USA.

J Dermatol 2017 Dec 3;44(12):1417-1418. Epub 2016 Dec 3.

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Hautarzt 2016 Dec;67(12):940-947

Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.

Background: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.

Objectives: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC).

Materials And Methods: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. Read More

Dermatol Online J 2016 Jun 16;22(6). Epub 2016 Jun 16.

Department of Dermatology, Centro Hospitalar do Porto, Oporto, Portugal.

Pyodermatitis vegetans (PV) is a rare inflammatory dermatosis of unknown etiology and difficult diagnosis characterized by vesiculopustular, exudative, and vegetating plaques usually localized in the axillary, genital, and oral region. It bears similarities to pemphigus vegetans but clinical history, histology, and immunofluorescence help confirm the diagnosis. Pyodermatitis vegetans is often associated with an underlying gastrointestinal disorder, especially ulcerative colitis. Read More

J Am Acad Dermatol 2016 Sep 24;75(3):578-584. Epub 2016 Jun 24.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Pyostomatitis vegetans (PSV)-pyodermatitis vegetans (PDV) is a rare inflammatory mucocutaneous disease associated with inflammatory bowel disease.

Objective: We sought to evaluate the clinicopathologic findings of PSV-PDV in a series of 7 patients.

Methods: We conducted a retrospective review of all cases of PSV-PDV at the Mayo Clinic from 1995 to 2014. Read More

Am J Dermatopathol 2016 Feb;38(2):148-50

*Department of Dermatology, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey; and †Department of Pathology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Pyoderma vegetans, a rare disorder of the skin, is considered a highly specific marker for inflammatory bowel disease, especially ulcerative colitis. It is clinically characterized by large verrucous plaques with elevated borders and multiple pustules. Here, the authors report the case of a 33-year-old man who was misdiagnosed as having verrucous carcinoma for 4 years. Read More

Am J Dermatopathol 2015 Sep;37(9):699-700, 730-2

*Georgetown University School of Medicine, Washington, DC; and †Department of Dermatology, Washington Hospital Center, Georgetown University, Washington, DC.

Rom J Morphol Embryol 2015 ;56(2):563-8

Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania;

Pyoderma vegetans is a rare disease characterized by the presence of vegetant exudative, pustular and erythematous vesiculobullous plaque usually located in the inguinal area and axillary fold. Etiology of pyoderma vegetans is unknown but it is often associated with bacterial infections in immunocompromised patients. Main histopathological characteristics of pyoderma crops are pseudoepitheliomatous hyperplasia and subepidermal, intraepidermal neutrophilic or eosinophilic microabscesses. Read More

Iran J Med Sci 2015 Jul;40(4):381-5

Pediatric Congenital Hematologic Disorders Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pyoderma vegetans (PV) is a rare inflammatory disorder characterized by vegetating pustules and plaques affecting the skin and mucosal membranes. It is believed that this entity is mostly associated with inflammatory bowel disease (IBD), chronic malnutrition, human immunodeficiency virus (HIV), malignancies, and other immunocompromised states. Pyoderma vegetans occurs more commonly in young and middle-aged adults. Read More

Middle East J Dig Dis 2015 Apr;7(2):104-6

Professor, Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Science,Tehran,Iran.

Some dermatologic manifestations are common in ulcerative colitis (UC). Herein, we present a 36-year-old woman with ulcerative colitis and uncommon nasal mucosa pyoderma vegetans. The patient presented to our hospital with symptoms of active colitis and a concomitant 3×4×5 cm dermato-mucosal lesion in her left nasal lumen. Read More

Rev Med Chir Soc Med Nat Iasi 2015 Jan-Mar;119(1):107-11

Pyoderma vegetans is a rare disorder that more commonly affects middle-aged persons, with a male predilection. It is characterized by vegetating lesions that coalescence into a plaque with eroded surface, covered by purulent discharge and crusts. The etiology of this disease is not known with certainty, but it is often associated with bacterial infections in immunocompromised patients. Read More

Br J Dermatol 2015 Mar 5;172(3):811-3. Epub 2015 Feb 5.

Section of Clinical, Allergological and Venereological Dermatology, Department of Medicine, University of Perugia, Perugia, 06156, Italy.

Genet Couns 2013 ;24(2):133-9

Department of Dermatology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.

GAPO syndrome is a rare autosomal recessive disease and an acronym composed of growth retardation, alopecia, pseudoanodontia, optic atrophy. Approximately 38 cases have been reported in literature until now. Pyoderma vegetans is a chronic inflammatory disease characterized with vesicopustular, exudative and vegetative lesions usually localized on face, scalp, axilla and genitalia. Read More

Dermatol Online J 2013 Jun 15;19(6):18558. Epub 2013 Jun 15.

Weill Cornell Medical College, New York, NY, USA.

Hidradenitis suppurativa (HS), a pathologic follicular disease, impacts patients' lives profoundly and usually occurs in isolation. The diseases with the strongest association are obesity, depression, and pain. HS is associated with many diseases including acne conglobata (AC), dissecting cellulitis, pilonidal cysts, and obesity. Read More

J Am Acad Dermatol 2013 Feb;68(2):211.e1-33; quiz 244-6

Division of Dermatology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA.

The gastrointestinal (GI) and cutaneous organ systems are closely linked. In part I of this continuing medical education article, the intricacies of this relationship were explored as they pertained to hereditary polyposis disorders, hamartomatous disorders, and paraneoplastic disease. Part II focuses on the cutaneous system's links to inflammatory bowel disease and vascular disorders. Read More

Ann Dermatol Venereol 2012 Dec 3;139(12):836-7. Epub 2012 Sep 3.

An Bras Dermatol 2012 Nov-Dec;87(6):929-31

University of Brasilia (Universidade de Brasilia - UnB) - Brasilia (DF), Brazil.

Pyodermatitis-pyostomatitis vegetans is a rare mucocutaneous dermatosis characterized by pustular and vegetating lesions of the skin and oral mucosa. It is considered a highly specific marker for inflammatory bowel diseases. The authors describe a case of pyodermatitis-pyostomatitis vegetans in a pediatric patient who presented marked clinical improvement after beginning treatment with oral corticosteroids, azathioprine, and dapsone. Read More