3,447 results match your criteria Pyoderma Gangrenosum


Quantification of the relationship between pyoderma gangrenosum and Crohn's disease: a population-based case-control study.

Scand J Gastroenterol 2020 Jul 7:1-5. Epub 2020 Jul 7.

Clalit Healthcare Services, Tel-Aviv, Israel.

Background: Although Crohn's disease (CD) is an established underlying disease in pyoderma gangrenosum (PG), studies comparing patients with PG and controls with respect to the presence of CD are lacking. Consequently, the relative risk imposed by CD for the development of PG is yet to be elucidated.

Objective: The study aims to quantify the magnitude of the association between CD and subsequent development of PG, thus enabling to evaluate the risk of PG with CD. Read More

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http://dx.doi.org/10.1080/00365521.2020.1786849DOI Listing

Pyoderma gangrenosum associated with chronic refractory pouchitis: a case successfully treated with infliximab.

Ann Gastroenterol 2020 Jul-Aug;33(4):433-435. Epub 2020 May 28.

Department of Gastroenterology (Eleni Orfanoudaki, Angeliki Machaira, Ioannis E. Koutroubakis).

Pouchitis-associated pyoderma gangrenosum (PG) is rare, with only a few cases reported in the literature. Here we report a rare case of chronic refractory pouchitis-associated PG successfully treated with infliximab (IFX). A 43-year-old Caucasian male, with a past medical history of chronic refractory pouchitis after proctocolectomy and ileal pouch-anal anastomosis for severe ulcerative colitis, developed PG on his right lower leg. Read More

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http://dx.doi.org/10.20524/aog.2020.0500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315701PMC

The dilemma of treating pyoderma gangrenosum associated with monoclonal gammopathy of undetermined significance.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Dermatology, Mohammed V Military Hospital, Mohammed V university of Rabat, Rabat.

Pyoderma gangrenosum (PG) is a rare ulcerative skin condition. It can be associated with a number of systemic diseases. Association with monoclonal gammopathy of undetermined significance (MGUS) is uncommon, but prognosis may be different depending upon the type of MGUS. Read More

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Granulomatous pyoderma gangrenosum in a patient with ulcerative colitis.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Dermatology, Fukushima Medical University, Fukushima.

A 34-year-old woman with a past history of inflammatory bowel disease developed a painful elevated edematous swelling with ulcerations on the dorsum of her left foot. Histopathological examination revealed dense infiltration of neutrophils and mononuclear cells in the lower dermis and subcutaneous tissue. Tumor necrosis factor (TNF) was strongly detected in giant cells. Read More

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The inpatient burden and comorbidities of pyoderma gangrenosum in adults in the United States.

Arch Dermatol Res 2020 Jul 3. Epub 2020 Jul 3.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Suite 2B-430, 2150 Pennsylvania Avenue, Washington, DC, 20037, USA.

Hospital admission is often necessary for management of pyoderma gangrenosum (PG), including wound care and pain control. No large-scale controlled studies examined the burden of hospitalization for PG. The objective of this study is to determine the prevalence, predictors, outcomes, and costs of hospitalization for PG in United States adults. Read More

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http://dx.doi.org/10.1007/s00403-020-02098-7DOI Listing

PAPA spectrum disorders.

G Ital Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical-Surgical Pathophysiology and Transplantation, University of Milan, Milan, Italy -

Pyogenic arthritis, pyoderma gangrenosum (PG) and acne (PAPA) syndrome is an autosomal dominant autoinflammatory syndrome due to mutations in proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) gene and presenting with cutaneous and articular manifestations. Other autoinflammatory syndromes caused by mutations in PSTPIP1 gene or characterized by clinical findings overlapping with those found in PAPA syndrome have been recently included in the group of PAPA spectrum disorders. These disorders are PASH (PG, acne and hidradenitis suppurativa [HS]), PAPASH (PASH associated with pyogenic sterile arthritis), PsAPASH (PASH combined with psoriatic arthritis [PsA], PASS (PG, acne, ankylosing spondylitis, with or without HS), PAC (PG, acne and ulcerative colitis [UC]) and PAMI syndrome (PSTPIP1-associated myeloid-related-proteinemia inflammatory syndrome). Read More

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http://dx.doi.org/10.23736/S0392-0488.20.06629-8DOI Listing

Rheumatoid arthritis and pyoderma gangrenosum: a population-based case-control study.

Clin Rheumatol 2020 Jul 1. Epub 2020 Jul 1.

Clalit Health Services, Tel-Aviv, Israel.

Background: The association between pyoderma gangrenosum (PG) and rheumatoid arthritis (RA) was not investigated in the setting of controlled studies. The risk of PG among patients with RA is not established.

Objective: The study aims to evaluate the magnitude of the association between RA and the subsequent development of PG. Read More

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http://dx.doi.org/10.1007/s10067-020-05253-7DOI Listing

Cyclosporin in Dermatology: A Practical Compendium.

Dermatol Ther 2020 Jun 30:e13934. Epub 2020 Jun 30.

Department of Medicine, The Aga Khan University Hospital, Karachi-Pakistan.

Cyclosporine A belongs to calcineurin inhibitor family, which has the ability to selectively suppress T-cells. Owing to its immune-modulatory effects, it had been in use for graft versus host diseases and organ transplant rejection for many years, but in dermatology, it was first approved for use in 1997 in the treatment of psoriasis. Other off label indications for skin diseases includes atopic dermatitis, chronic spontaneous urticaria, lichen planus, pyoderma gangrenosum, alopecia areata, granuloma annulare and several others. Read More

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http://dx.doi.org/10.1111/dth.13934DOI Listing

Editorial: peristomal pyoderma gangrenosum-a challenge for patients, healthcare professionals and research.

Aliment Pharmacol Ther 2020 Jul;52(2):404-405

Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/apt.15822DOI Listing

Pyoderma gangrenosum of the tongue.

Br J Hosp Med (Lond) 2020 Jun;81(6):1-4

Department of Oral Medicine, Dental Institute, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.12968/hmed.2019.0386DOI Listing

Protocol for an International, Multicenter, Hyperbaric Oxygen Treatment Registry and Research Consortium.

JMIR Res Protoc 2020 Jun 23. Epub 2020 Jun 23.

Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, US.

Background: Background: Hyperbaric oxygen (HBO2) (oxygen at pressures higher than atmospheric) is approved for 14 indications by the Undersea and Hyperbaric Medical Society. HBO2's main effect is to increase oxygen content in plasma and body tissues, which can counteract hypoxia or ischemia. Laboratory studies show that hyperbaric oxygen has effects beyond relieving hypoxia (e. Read More

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http://dx.doi.org/10.2196/18857DOI Listing

Cutaneous cryptococcosis simulating pyoderma gangrenosum.

Rev Soc Bras Med Trop 2020 12;53:e20200120. Epub 2020 Jun 12.

Hospital do Servidor Público Estadual de São Paulo, Programa de Residência Médica em Dermatologia, São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/0037-8682-0120-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294955PMC

Cytapheresis for pyoderma gangrenosum associated with inflammatory bowel disease: A review of current status.

World J Clin Cases 2020 Jun;8(11):2092-2101

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan.

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis clinically characterized by the presence of painful skin ulcerations with erythematous. As it is frequently associated with inflammatory bowel diseases, including ulcerative colitis, gastroenterologists should be familiar with the disease including therapeutic options. Therefore, we have conducted a review focusing on the cytapheresis for PG in cases of inflammatory bowel diseases. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281039PMC

Isavuconazonium for the treatment of Purpureocillium lilacinum infection in a patient with pyoderma gangrenosum.

Med Mycol Case Rep 2020 Sep 30;29:18-21. Epub 2020 May 30.

Tulane University, Department of Medicine, 1415 Tulane Avenue, 70112, New Orleans, United States.

Purpureocillium lilacinum is a rare but emerging pathogen in immunocompromised patients that primarily infects the skin and subcutaneous tissue. We present a novel case of Purpureocillium lilacinum infection in a patient with pyoderma gangrenosum who was successfully treated with isavuconazonium, followed by a literature review of 13 total cases of infection with Purpureocillium lilacinum gathered from a review of the PubMed database. Previous reports have utilized voriconazole, an antifungal with significant toxic side effects. Read More

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http://dx.doi.org/10.1016/j.mmcr.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286926PMC
September 2020

Tackling key immunological and immuno-dermatological pathways and their link to treatment options.

Authors:
Daniel Boda

Exp Ther Med 2020 Jul 4;20(1):9-11. Epub 2020 May 4.

Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

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http://dx.doi.org/10.3892/etm.2020.8712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282104PMC

Neutrophilic dermatosis of the dorsal hands triggered by mechanical trauma.

J Eur Acad Dermatol Venereol 2020 Jun 13. Epub 2020 Jun 13.

Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.

Since the first descriptions by Strutton et al., neutrophilic dermatosis of the dorsal hands (NDDH) has now been recognized as a distinctive localized form of either pustular Sweet syndrome (SS) or of bullous or ulcerative pyoderma gangrenosum (PG). Although the lesions are characteristically located on the dorsa of the hands and the fingers, additional locations may be affected. Read More

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http://dx.doi.org/10.1111/jdv.16750DOI Listing

A case of sporotrichosis infection mimicking pyoderma gangrenosum and the role of tissue culture in diagnosis: A case report.

SAGE Open Med Case Rep 2020 18;8:2050313X20919600. Epub 2020 May 18.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Sporotrichosis infections may cause cutaneous lesions mimicking other infectious or non-infectious causes such as pyoderma gangrenosum. We present a case of cutaneous sporotrichosis misdiagnosed as pyoderma gangrenosum and treated with immunosuppressants for 17 months leading to exacerbation and atypical morphology mimicking organisms on biopsy. Exclusion of infection prior to diagnosing pyoderma gangrenosum is important to prevent iatrogenic immunosuppression, demonstrating the challenges with application of the updated pyoderma gangrenosum diagnostic criteria. Read More

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http://dx.doi.org/10.1177/2050313X20919600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235660PMC

Negative Pressure Wound Therapy in Pyoderma Gangrenosum Treatment.

Am J Case Rep 2020 Jun 10;21:e922581. Epub 2020 Jun 10.

Institute of Nursing and Health Sciences, Faculty of Medicine, College of Medical Sciences, University of Rzeszów, Rzeszów, Poland.

BACKGROUND Pyoderma gangrenosum (PG) is a rare, non-infectious, fulminant dermatosis of the skin. The lack of objective diagnostic criteria requires differential diagnosis and exclusion of extensive ulcerative skin diseases. Currently, treatment includes a combination of systemic steroids, immunosuppressants, and topical agents, but after decades of research, no clear scientific evidence exists for a criterion standard treatment. Read More

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http://dx.doi.org/10.12659/AJCR.922581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304651PMC

Altered keratinization and vitamin D metabolism may be key pathogenetic pathways in syndromic hidradenitis suppurativa: a novel whole exome sequencing approach.

J Dermatol Sci 2020 May 22. Epub 2020 May 22.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Physiopathology and Transplantation, Università degli Studi di Milano Via Pace 9, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. Electronic address:

Background: Diagnosis of pyoderma gangrenosum, acne and hidradenitis suppurativa (PASH) and pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PAPASH) patients, in spite of recently identified genetic variations, is just clinical, since most patients do not share the same mutations, and the mutations themselves are not informative of the biological pathways commonly disrupted in these patients.

Objective: To reveal genetic changes more closely related to PASH and PAPASH etiopathogenesis, identifying novel common pathways involved in these diseases.

Methods: Cohort study on PASH (n = 4) and PAPASH (n = 1) patients conducted using whole exome sequencing (WES) approach and a novel bioinformatic pipeline aimed at discovering potentially candidate genes selected from density mutations and involved in pathways relevant to the disease. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.05.004DOI Listing

Pyoderma gangrenosum and suppurative hidradenitis association, overlap or spectrum of the same disease? Case report and discussion.

Exp Ther Med 2020 Jul 30;20(1):38-41. Epub 2019 Oct 30.

Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, Romania.

Suppurative hidradenitis and pyoderma gangrenosum are rare disorders that can be seen isolated or even more rare, as part of different autoinflammatory syndromes: Pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH), pyoderma gangrenosum, acne, pyogenic arthritis, and hidradenitis suppurativa (PAPASH) or psoriatic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PsAPASH). Although they have different clinical features, suppurative hidradenitis and pyoderma gangrenosum seem to share similar pathogenic pathways involving a dysregulated innate immune system, with neutrophilic inflammation, mediated by IL-1β, controlled by NALP3 inflammasome pathway. We report a case of a 53-year-old male patient previously diagnosed with HS in inguinal-scrotal area that developed rapidly after a traumatic injury on his left anterior calf, a painful inflammatory plaque with pustules on the surface that rapidly progressed (24-48 h) to form ulcers. Read More

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http://dx.doi.org/10.3892/etm.2019.8150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271694PMC

Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease.

Authors:
Toshifumi Nomura

Front Immunol 2020 20;11:847. Epub 2020 May 20.

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition, clinically characterized by boiled cysts, comedones, abscesses, hypertrophic scars, and/or sinus tracts typically in the apocrine-gland-rich areas such as the axillae, groin, and/or buttocks. Although its precise pathogenic mechanisms remain unknown, I herein emphasize the importance of the following three recent discoveries in the pathogenesis of HS: First, heterozygous loss-of-function mutations in the genes encoding γ-secretase, including , and , have been identified in some patients with HS. Such genetic alterations result in hyperkeratosis, dysregulated hair follicle differentiation, and cyst formation via aberrant Notch signaling. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251184PMC

Expert Commentary on the Management of Peristomal Pyoderma Gangrenosum in a Patient With IBD.

Authors:
Jeffrey P Callen

Dis Colon Rectum 2020 Jul;63(7):885-886

Division of Dermatology, University of Louisville, Louisville, Kentucky.

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http://dx.doi.org/10.1097/DCR.0000000000001704DOI Listing

The Management of Peristomal Pyoderma Gangrenosum in IBD.

Dis Colon Rectum 2020 Jul;63(7):881-884

Price Institute of Surgical Research, The Hiram C. Polk Jr., M.D. Department of Surgery, University of Louisville, Louisville, Kentucky.

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http://dx.doi.org/10.1097/DCR.0000000000001701DOI Listing

Is Gout Associated with Pyoderma Gangrenosum? A Population-Based Case-Control Study.

J Clin Med 2020 May 28;9(6). Epub 2020 May 28.

Clalit Health Services, 6264705 Tel-Aviv, Israel.

The coexistence of pyoderma gangrenosum (PG) and gout has been reported in individual patients; however, the association between these conditions has not been investigated. We aimed to assess the association between PG and gout and to examine whether the presence of gout predisposes to the development of PG. A population-based case-control study was conducted comparing PG patients ( = 302) with age-, sex-, and ethnicity-matched control subjects ( = 1497) with respect to the presence of preceding gout. Read More

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http://dx.doi.org/10.3390/jcm9061626DOI Listing

Pyoderma Gangrenosum Over Hypertrophic Scar: Report of a Rare Presentation.

Indian Dermatol Online J 2020 Mar-Apr;11(2):222-225. Epub 2020 Mar 9.

Department of Dermatology, AIIMS, Bhubaneswar, Odisha, India.

Pyoderma gangrenosum (PG) is a chronic neutrophilic dermatoses characterised by large ulcer healing with cribriform scar. PG can rarely occur over the healed scar. Its diagnosis depends on clinical morphology and exclusion of other diseases. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_153_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247654PMC

A child with recurrent pyogenic arthritis with the PSTPIP1 mutation.

Authors:
Yan-Nan Guo

SAGE Open Med Case Rep 2020 28;8:2050313X20918988. Epub 2020 Apr 28.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome is a rare disease, linked to an auto-inflammatory pathway. We report a 7-year-old boy with recurrent suppurative knee arthritis without signs of suppurative skin infection or ulcer; his younger brother had the same symptom. Genetic testing indicated the presence of proline-serine-threonine phosphatase interacting protein 1 gene mutation in both boys. Read More

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http://dx.doi.org/10.1177/2050313X20918988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233890PMC

Sunitinib-induced pyoderma gangrenosum-like skin ulcer.

CMAJ 2020 May;192(20):E552

Department of Dermatology, Venereology, and Allergology, HELIOS St. Elisabeth, Hospital Oberhausen, University Witten-Herdecke, Oberhausen, Nordrhein-Westfalen, Germany

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http://dx.doi.org/10.1503/cmaj.191165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241889PMC
May 2020
5.959 Impact Factor

Paradoxical Skin Reaction to Certolizumab, an Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis: Case Report with Literature Review.

Dermatol Ther (Heidelb) 2020 May 23. Epub 2020 May 23.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wrocław, Poland.

Introduction: Biologic agents form an indispensable part of modern therapeutic regimens for the treatment of severe inflammatory diseases, especially in the fields of rheumatology, dermatology and gastroenterology. They are favoured by both physicians and patients due to their high effectiveness, good patient tolerance and safety. However, interference in the regulation and dynamics of inflammatory cytokines can on occasion lead to an onset of a dermatological condition also known as paradoxical skin reaction. Read More

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http://dx.doi.org/10.1007/s13555-020-00398-4DOI Listing

Comparison of Three Diagnostic Frameworks for Pyoderma Gangrenosum.

J Invest Dermatol 2020 May 20. Epub 2020 May 20.

Department of Dermatology, Oregon Health & Science University, Portland, OR, USA. Electronic address:

Pyoderma gangrenosum (PG) is an inflammatory condition characterized by chronic cutaneous ulcerations. There are three proposed PG diagnostic frameworks (Su, PARACELSUS, Delphi); however, they lack consensus, and their performance has not yet been validated in a well-defined cohort of PG patients. In this cross-sectional retrospective cohort study, we sought to evaluate and compare the concordance of these diagnostic frameworks within a single institution cohort of PG patients. Read More

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http://dx.doi.org/10.1016/j.jid.2020.04.019DOI Listing

Peristomal pyoderma gangrenosum: Report on 11 cases.

J Dermatol 2020 May 22. Epub 2020 May 22.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

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http://dx.doi.org/10.1111/1346-8138.15396DOI Listing

Pyoderma Gangrenosum Masquerading as Necrotizing Infection after Autologous Breast Reconstruction.

Plast Reconstr Surg Glob Open 2020 Apr 10;8(4):e2596. Epub 2020 Apr 10.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, D.C.

Pyoderma gangrenosum (PG) is a diagnostic dilemma when it presents with a superimposed infection and previous surgery without subsequent inflammatory infection. In this setting, PG is not at the forefront of the surgeon's mind. Furthermore, the treatment for PG, systemic steroids, may cause serious morbidity if the necrotizing infection is the actual culprit. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209838PMC

Pyoderma Gangrenosum and Superimposed Infection: A Case Report.

Adv Skin Wound Care 2020 Jun;33(6):1-3

Elizabeth M. Gavioli, PharmD, is Assistant Professor of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, 1 University Plaza, Brooklyn, NY, and Clinical Pharmacy Specialist, Mount Sinai Beth Israel, First Avenue at 16th St, New York. Michael Casias, PharmD, is Assistant Professor of Pharmacy Practice, Rutgers, The State University of New Jersey, Piscataway Township, NJ. Linda Ngo, PharmD, is Pharmacist, New York Presbyterian Weill Cornell Medical Center, New York, NY. The authors have disclosed no financial relationships related to this article. Submitted May 17, 2019; accepted in revised form September 13, 2019.

Pyoderma gangrenosum (PG) is a rare, ulcerating, inflammatory disease that is often misdiagnosed as a skin and soft tissue infection. If PG is identified, it is treated with topical or systemic immunosuppressants to reduce inflammation and induce remission. However, the use of immunosuppressants has been linked to a higher risk of superimposed infections. Read More

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http://dx.doi.org/10.1097/01.ASW.0000661796.90753.f3DOI Listing

Pyoderma gangrenosum confused with congenital preauricular fistula infection: A case report.

World J Clin Cases 2020 May;8(9):1679-1684

Department of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Pyoderma gangrenosum resulting from or associated with congenital preauricular fistula is rarely reported.

Case Summary: We report a rare case of pyoderma gangrenosum misdiagnosed as preauricular fistula infection. To our knowledge, this is the first report to describe pyoderma gangrenosum originating from the site of preauricular fistula. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i9.1679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211529PMC

Canakinumab in colchicine resistant familial Mediterranean fever and other pediatric rheumatic diseases.

Turk J Pediatr 2020 ;62(2):167-174

Clinic of Pediatric Rheumatology, Kanuni Sultan Süleyman Research and Training Hospital, İstanbul, Turkey.

Background And Objectives: The aim of this observational retrospective cohort study was to demonstrate indications and response rates of the patients with pediatric rheumatic diseases that used canakinumab.

Method: The files of the patients that used canakinumab between December 2012 and July 2017 were reviewed. Canakinumab was used in 29 patients. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.001DOI Listing
January 2020

Post-surgical skin ulcers due to cytomegalovirus vasculopathy in a renal transplant recipient.

JAAD Case Rep 2020 May 11. Epub 2020 May 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211735PMC

Risk factors and treatment outcomes of peristomal pyoderma gangrenosum in patients with inflammatory bowel disease.

Aliment Pharmacol Ther 2020 Jun 7;51(12):1365-1372. Epub 2020 May 7.

Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL, USA.

Background: Insufficient data exist for peristomal pyoderma gangrenosum (PPG), which primarily affects patients with inflammatory bowel disease (IBD).

Aims: To evaluate the risk factors and treatment response of PPG in IBD patients in a real-life cohort.

Methods: Cases of PPG were identified retrospectively using ICD-9/10 codes in patients with IBD who had an ostomy at a tertiary care centre. Read More

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http://dx.doi.org/10.1111/apt.15766DOI Listing

Pyoderma gangrenosum: From historical perspectives to emerging investigations.

Int Wound J 2020 May 6. Epub 2020 May 6.

Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.

Pyoderma gangrenosum (PG) is a rare disease of unknown aetiology, first described over a century ago. Initially thought to have an infectious cause, and now primarily considered an autoinflammatory condition, PG continues to be poorly understood, commonly misdiagnosed, and difficult to treat. In this review, we discuss the journey of our understanding of PG to date, including first descriptions, challenges with diagnosis, presumed pathogenesis, and treatments used. Read More

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http://dx.doi.org/10.1111/iwj.13389DOI Listing

Cutaneous Manifestations of Granulomatosis with Polyangiitis: A Case Series Study.

Acta Derm Venereol 2020 May 28;100(10):adv00150. Epub 2020 May 28.

Department of Dermatology, Virgen de las Nieves University Hospital, ES-18014 Granada, Spain.

The aim of this study was to determine the prevalence and type of cutaneous manifestations which occur in patients with granulomatosis with polyangiitis and to explore the potential association between cutaneous and systemic involvement in these patients. A retrospective case series study was designed, including all granulomatosis with polyangiitis cases diagnosed between 2010 and 2018 at the Hospital Universitario Virgen de las Nieves. Thirty-nine patients with granulomatosis with polyangiitis were identified, of which 53. Read More

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http://dx.doi.org/10.2340/00015555-3506DOI Listing

Pyoderma gangrenosum after cardiac surgery.

J Card Surg 2020 May 4. Epub 2020 May 4.

Division of Cardiac surgery, Dalhousie University, Halifax, Canada.

Pyoderma gangrenosum (PG) can mimic early postoperative sternal wound infections. Steroid therapy is the only method of treatment for this condition, which recognizes the fact that steroids can lead to immunosuppression and potentially inhibit healing after major surgery. Read More

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http://dx.doi.org/10.1111/jocs.14616DOI Listing

Novel Therapeutic Approaches and Targets for Treatment of Neutrophilic Dermatoses.

Curr Pharm Biotechnol 2020 May 2. Epub 2020 May 2.

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona. Italy.

Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders characterized by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. Universally accepted and validated guidelines for the management of neutrophilic dermatoses do not exist, also given the paucity of randomized controlled study and high-quality data. However, the literature on the effective use of biologic therapies is rapidly expanding. Read More

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http://dx.doi.org/10.2174/1389201021666200503050803DOI Listing

Pyoderma gangrenosum complicating a permanent pacemaker implantation: a case report and literature review.

Eur Heart J Case Rep 2020 Apr 12;4(2):1-7. Epub 2020 Mar 12.

Department of Dermatology, Centre Hospitalier Annecy Genevois, 1 Avenue de l'Hôpital, 74370 Metz-Tessy, France.

Background: Pocket complications are common after cardiac implantable electronic device implantation. We report a rare case of pyoderma gangrenosum (PG) complicating a permanent pacemaker implantation, and the first literature review of 10 published cases.

Case Summary: Five days after pacemaker implantation for heart failure and 2:1 atrioventricular block, a 93-year-old man had pain in the scar and bleeding on contact. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180522PMC

The Use of TNFα Inhibitors in Treating Pediatric Skin Disorders.

Paediatr Drugs 2020 Jun;22(3):311-319

Department of Dermatology, UTHealth McGovern Medical School at Houston, Houston, TX, USA.

Tumor necrosis factor alpha (TNF) inhibitors have had a significant impact in medicine since the approval of the first drug of its class by the US FDA in 1998. New clinical data and indications have emerged for TNF inhibitors in recent years. Currently, four TNF inhibitors have been approved by the US FDA for dermatology, two of which include US FDA-approved pediatric use. Read More

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http://dx.doi.org/10.1007/s40272-020-00394-3DOI Listing

When infection isn't infection.

Ann R Coll Surg Engl 2020 Apr 29:e1-e2. Epub 2020 Apr 29.

Imperial College Healthcare NHS Trust, London, UK.

Following open reduction and internal fixation for a proximal humerus fracture a 71-year-old man re-presented with wound changes consistent with infection and elevated inflammatory markers. No significant improvement was seen with concomitant intravenous antibiotics and multiple debridement procedures. This case was further complicated by soft tissue breakdown at the site of a left thigh haematoma also requiring debridement. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0091DOI Listing

Dual-targeted therapy with apremilast and vedolizumab in pyoderma gangrenosum associated with Crohn's disease.

J Dermatol 2020 Jun 29;47(6):e216-e217. Epub 2020 Apr 29.

Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1111/1346-8138.15283DOI Listing
June 2020
2.354 Impact Factor

Pediatric facial pyoderma gangrenosum preceding the diagnosis of inflammatory bowel disease.

Pediatr Dermatol 2020 Apr 27. Epub 2020 Apr 27.

Department of Dermatology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

We describe two adolescent patients with pyoderma gangrenosum (PG) involving the face. Subsequent gastrointestinal evaluation revealed microscopic bowel inflammation suggestive of inflammatory bowel disease. While PG is rarely localized to the face, this brief report reveals two cases of pediatric facial PG and suggests a correlation between facial PG and microscopic colitis. Read More

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http://dx.doi.org/10.1111/pde.14186DOI Listing

Successful Mastectomy and Chemotherapy in a Patient with Breast Cancer and Active Generalized Pyoderma Gangrenosum.

Wounds 2020 Apr;32(4):E19-E22

Department of Dermatology and Wound care and Hyperbaric Medicine, Oregon Health and Science University, Portland, OR.

Introduction: Pyoderma gangrenosum (PG) is a rare, ulcerating neutrophilic dermatosis often associated with inflammatory bowel disease, rheumatoid arthritis, and myeloproliferative disorders. The classic description of PG includes irregularly shaped ulcers with undermined edges with a gun-metal gray or violaceous hue. The etiology remains unclear but appears to be related to genetically predisposed dysregulation of the innate immune system. Read More

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