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    2859 results match your criteria Pyoderma Gangrenosum

    1 OF 58

    Skin Manifestations of Inflammatory Bowel Disease.
    Clin Rev Allergy Immunol 2017 Jun 23. Epub 2017 Jun 23.
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
    Inflammatory bowel disease (IBD) with its two main subtypes Crohn's disease and ulcerative colitis is not restricted to the gastrointestinal tract. Indeed, so-called extraintestinal manifestations (EIMs) are frequent and considerably affect morbidity and mortality. The prevalence of EIMs ranges from 6 to 47%. Read More

    [Chronic leg ulcers].
    Hautarzt 2017 Jun 21. Epub 2017 Jun 21.
    Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland.
    Chronic wounds often manifest as ulcers on the lower legs. The main causes of chronic leg ulcers are chronic venous insufficiency and/or peripheral arterial occlusive disease in approximately 80% of all patients. However, there are also numerous other potentially relevant factors which can cause or almost impede the healing of chronic leg ulcers. Read More

    Pyoderma gangrenosum and underlying diseases in Japanese patients: A regional long-term study.
    J Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
    Pyoderma gangrenosum (PG) is a chronic inflammatory disease of unknown cause that presents as an inflammatory and ulcerative disorder of the skin. PG is often associated with an underlying systemic disease. However, the frequencies of the underlying diseases are unclear in Japanese patients. Read More

    Pyoderma gangrenosum: Classic and emerging therapies.
    Med Clin (Barc) 2017 Jun 16. Epub 2017 Jun 16.
    Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:
    Pyoderma gangrenosum is an ulceronecrotising dermatosis that represents a challenge for any clinician, not only for its ability to mimic other dermatoses but also for its lack of response to treatment. During the past year, there have been new studies about the efficacy of standard therapies, such as cyclosporine and systemic corticosteroids. These studies showed that classic treatment was comparable, but they are insufficient as monotherapy. Read More

    Haematological involvement associated with a mild autoinflammatory phenotype, in two patients carrying the E250K mutation of PSTPIP1.
    Clin Exp Rheumatol 2017 Jun 19. Epub 2017 Jun 19.
    Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
    Objectives: Hyperzincaemia/hypercalprotectinemia (Hz/Hc) syndrome is a recently described condition caused by a specific de novo mutation (E250K) affecting PSTPIP1 gene. It has a phenotype distinct from classical pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome that includes severe systemic and cutaneous inflammation, hepatosplenomegaly, arthritis without sequelae, pancytopenia and failure to thrive.

    Methods: We describe an 8-year-old boy who presented recurrent right knee swelling mimicking septic arthritis and persistent bone marrow involvement, without cutaneous involvement. Read More

    Sporotrichosis masquerading as pyoderma gangrenosum.
    J Eur Acad Dermatol Venereol 2017 Jun 19. Epub 2017 Jun 19.
    Hospital Copa D'Or.
    Sporotrichosis is a subcutaneous mycosis with a worldwide distribution caused by species of the Sporothrix schenkii complex. Since 1998, it has reached epidemic proportions in the city of Rio de Janeiro, Brazil, via transmission from infected cats to humans. The species identified as the primary cause was Sporothrix brasiliensis. Read More

    PASH syndrome a disease with genetic heterogeneity.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Department of Dermatology and Venereology, University Hospital of Brest.
    PASH syndrome is a clinical entity associating pyoderma gangrenosum (PG), severe acne and hidradenitis suppurativa (HS)(1) . Absence of pyogenic sterile arthritis (PA) distinguishes PASH syndrome from PAPASH and PAPA syndromes which associate PA in combination with PG, severe acne with or without HS, respectively(2,3) . Mutations in PSTPIP1 (proline-serine-threonine-phosphatase interacting protein 1) gene were identified in patients with PAPA and PAPASH syndromes, although genetic heterogeneity was observed in PAPA syndrome(2,3) . Read More

    Drug-Induced Pyoderma Gangrenosum: A Review.
    Am J Clin Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    York Dermatology Centre, Toronto, ON, Canada.
    Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMed and Medical Subject Heading (MeSH) terms on MEDLINE and EMBASE. Read More

    Saddle-nose and bilateral cauliflower ear deformities with pyoderma gangrenosum-like ulcers, cavitary pulmonary lesions, digital gangrene and pulselessness in a young female.
    BMJ Case Rep 2017 Jun 15;2017. Epub 2017 Jun 15.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
    We report a young female who presented with saddle-nose and bilateral cauliflower ear deformities along with pyoderma gangrenosum-like ulcers, digital gangrene and pulselessness. Subsequently, she was found to have bilateral conductive hearing loss, a corneal opacity, mild aortic regurgitation and radiological evidence of cavitary changes in lungs and aortoarteritis. Our patient had a constellation of symptoms which posed a diagnostic challenge. Read More

    Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy.
    Indian J Hematol Blood Transfus 2017 Jun 11;33(2):273-275. Epub 2016 Aug 11.
    Department of Internal Medicine and Hematology, 4th Floor, Nehru Hospital, PGIMER, Chandigarh, India.
    Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis seen in association with systemic disorders including hematologic malignancies. Hairy cell leukemia (HCL) however, is an unusual association of PG. We describe a 49-year old lady who presented to our hematology clinic with easy fatiguability and ulcerative skin lesions of 6 months duration. Read More

    Efficacy of cytapheresis for remission induction and dermatological manifestations of ulcerative colitis.
    J Clin Apher 2017 Jun 5. Epub 2017 Jun 5.
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
    Background: In ulcerative colitis (UC) patients, cytapheresis depletes elevated and activated leucocytes, which are known to release inflammatory cytokines including tumor necrosis factor (TNF)-α. Further, there are UC patients who develop erythema nodosum (EN) or pyoderma gangrenosum (PG) as extra-intestinal manifestations of UC.

    Methods: Between 2008 and 2015, 181 consecutive patients with active UC received cytapheresis with either a granulocyte and monocyte apheresis (GMA) column or with a leucocyte removal filter (LCAP) as remission induction therapy. Read More

    [Evidence of compression therapy].
    Hautarzt 2017 Jun 2. Epub 2017 Jun 2.
    Klinik- und Poliklinik für Haut- und Geschlechtskrankheiten, Universitätsmedizin Greifswald, F.-Sauerbruchstr., 17475, Greifswald, Deutschland.
    Background: Medical compression therapy is widely used to treat phlebologic diseases. Compression bandages as well as compression stockings are used. Compression has been identified to be an effective conservative therapy for the healing of venous ulcers and other indications. Read More

    Cutaneous Manifestations of Medium- and Large-Vessel Vasculitis.
    Clin Rev Allergy Immunol 2017 May 26. Epub 2017 May 26.
    Université Pierre et Marie Curie-Paris VI, Assistance Publique-Hôpitaux de Paris, Service de Dermatologie-Allergologie, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
    Dermatologic manifestations are observed in almost all systemic vasculitides, even in large-and medium-vessel vasculitides, although such vessels are not found in the skin. Cutaneous manifestations may be related to a direct skin localization of the systemic vasculitis or a non-specific process associated with the vasculitis. According to the 2012 International Chapel Hill consensus, the two major variants of large-vessel vasculitides are Takayasu arteritis and giant-cell arteritis. Read More

    The Pathergy Test as a Diagnostic Tool.
    Skinmed 2017 1;15(2):97-104. Epub 2017 Apr 1.
    Dermatology Unit, Kaplan Medical Center, Rechovot, Israel.
    The pathergy test produces a nonspecific hyperreactive lesion in Behçet's disease (BD), a finding that has been known since 1937. Pathergy refers to the development of new skin lesions or the aggravation of existing ones after trivial trauma. In clinical practice, the pathergy test induces a skin response by needleprick, with positive reactions manifesting as a papule or pustule developing by 48 hours. Read More

    [Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report].
    Rev Med Brux 2017 ;38(2):95-98
    Département de Médecine interne générale, Groupe Jolimont.
    Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. This entity is associated with systemic diseases and autoimmune diseases but exceptionally with autoimmune hepatitis. We report the case of a 40 year-old woman diagnosed with type 1 autoimmune hepatitis 12 years earlier and admitted for the appearance of an ulcerative lesion in the left leg. Read More

    [Pathergic postsurgical-induced Pyoderma gangrenosum].
    Rev Med Liege 2017 May;72(5):227-232
    Service de Chirurgie Plastique, Esthétique et Reconstructrice, Clinique Saint-Vincent de Rocourt (CHC), Liège, Belgique.
    Pyoderma gangrenosum (PG) is a rare pustular and ulcerative inflammatory disease belonging to the group of neutrophilic dermatoses. It is frequently associated with systemic immune diseases. In this context the PG can be exceptionally triggered by tissue trauma such as surgery (pathergy). Read More

    T helper type 1-related molecules as well as interleukin-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum.
    Clin Exp Immunol 2017 May 18. Epub 2017 May 18.
    Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy.
    Pyoderma gangrenosum (PG) is a rare, immune-mediated skin disease classified into the group of neutrophilic dermatoses. Although a number of studies confirmed the central role of innate immunity, only few studies have investigated the possible contributing role of acquired immunity. In particular, no reports concerning T helper type 1 (Th1) and Th2 cells are available as yet. Read More

    Pyoderma Gangrenosum after Deep Inferior Epigastric Perforator Breast Reconstruction: Systematic Review and Case Report.
    Plast Reconstr Surg Glob Open 2017 Apr 21;5(4):e1239. Epub 2017 Apr 21.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, N.H.
    Background: Pyoderma gangrenosum (PG) is a rare skin disorder of the neutrophilic dermatoses spectrum that can mimic wound infections in surgical patients. PG after breast surgery has been reported but in limited amounts in autologous breast reconstruction patients. We present the first case of PG after a delayed bilateral deep inferior epigastric perforator flap breast reconstruction in the setting of systemic disease along with a systematic review. Read More

    [Penile Tuberculosis : A Case Report].
    Hinyokika Kiyo 2017 Apr;63(4):163-167
    The Department of Infection Control Team, Osaka Police Hospital.
    A 66-year-old man presented with a chief complaint of glans penis pain, induration, and discharge of pus. He was prescribed a course of antibiotics, but the condition persisted despite treatment. Thus, we differrentially diagnosed the patient with penile tuberculosis and pyoderma gangrenosum, and performed a biopsy of the penis. Read More

    Pyoderma gangrenosum with pathergy: A potentially significant complication following breast reconstruction.
    J Plast Reconstr Aesthet Surg 2017 Apr 12. Epub 2017 Apr 12.
    Department of Dermatology, Middlemore Hospital, Counties Manukau District Health Board, 100 Hospital Road, Private Bag 93311, Otahuhu, Auckland, New Zealand; Department of Medicine, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand. Electronic address:
    The failure of postoperative surgical site infection to resolve after appropriate antibiotic therapy should alert the clinician to other diagnoses. Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis that is typically characterized by necrotizing ulceration. PG can be exacerbated by minor trauma leading to exaggerated skin injury, a condition known as pathergy. Read More

    Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment.
    J Cutan Med Surg 2017 May 1:1203475417708164. Epub 2017 May 1.
    4 University of Missouri Kansas City, Department of Internal Medicine, Kansas City, MO, USA.
    Acute cutaneous necrosis is characterised by a wide range of aetiologies and is associated with significant morbidity and mortality, warranting complex considerations in management. Early recognition is imperative in diagnosis and management of sudden gangrenous changes in the skin. This review discusses major causes of cutaneous necrosis, examines the need for early assessment, and integrates techniques related to diagnosis and management. Read More

    Pyoderma gangrenosum in a pregnant patient: A case report and literature review.
    J Obstet Gynaecol Res 2017 Apr;43(4):775-778
    Department of Obstetrics and Gynecology, Toho University Medical Center-Sakura Hospital, Chiba, Japan.
    Pyoderma gangrenosum (PG) is a rare ulcerative skin disease that usually starts as a pustular lesion and rapidly progresses to a painful ulcer with undermined violaceous borders. The occurrence of PG during pregnancy is uncommon. We describe a case of a pregnant patient with PG who was diagnosed as having ulcerative colitis after delivery. Read More

    Recalcitrant cases of pyoderma gangrenosum, responding dramatically to systemic tacrolimus.
    G Ital Dermatol Venereol 2017 Jun;152(3):308-310
    Department of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous disease, without any well-known specific and effective treatment. Here we report two patients with severe recalcitrant perineal pyoderma gangrenosum, successfully treated with low dose systemic tacrolimus. Tacrolimus can be a safe effective drug in the management of recalcitrant PG. Read More

    Postsurgical Pyoderma Gangrenosum Following Carpal Tunnel Release: A Rare Disease Following a Common Surgery.
    Eplasty 2017 21;17:e10. Epub 2017 Mar 21.
    Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, IL.
    Objective: Postsurgical pyoderma gangrenosum is a rare but potentially devastating condition for surgical patients. While pyoderma gangrenosum has 2 subtypes, typical and atypical, each can be further classified by its heralding features. These include ulcerative, pustular, bullous, and vegetative. Read More

    Ciclosporin compared with prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial.
    Br J Dermatol 2017 Apr 9. Epub 2017 Apr 9.
    Centre of Evidence Based Dermatology, University of Nottingham, NG7 2NR, U.K.
    Background: Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomized controlled trial (RCT).

    Objectives: To compare the cost-effectiveness of ciclosporin and prednisolone-initiated treatment for patients with PG. Read More

    Clinical update on inflammasomopathies.
    Int Immunol 2017 Apr 6. Epub 2017 Apr 6.
    Department of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey.
    Inflammasomes are important elements of the innate immune defense. The most common autoinflammatory syndromes, as well a number of rare ones, are due to hereditary defects in the inflammasomes, hence are called inflammasomopathies. The recent clinical advances in these diseases will be reviewed, with special emphasis on reflecting the international collaborative work in the field. Read More

    Postsurgical Pyoderma Gangrenosum Versus Necrotizing Fasciitis: Can We Spot the Difference?
    Ann Plast Surg 2017 May;78(5):582-586
    From the Department of Plastic Surgery, Countess of Chester Hospital, Chester, PA.
    Background: Pyoderma gangrenosum is a rare noninfectious cutaneous disease characterized by expanding areas of skin ulceration around necrotic centers with purulent debris. Exceptionally, it can be precipitated by surgery alone, and this entity has been described as postsurgical pyoderma gangrenosum (PSPG). Cases of PSPG in the literature are rare. Read More

    A case of breakthrough Candida parapsilosis fungemia during micafungin therapy for a Candida glabrata bloodstream infection.
    Med Mycol Case Rep 2017 Jun 23;16:1-3. Epub 2017 Mar 23.
    Department of Infectious Diseases, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo 187-8510, Japan.
    We describe a case of breakthrough Candida parapsilosis fungemia in an 80-year-old woman with pyoderma gangrenosum and rheumatoid arthritis. C. parapsilosis was detected in blood culture while the patient was treated with micafungin for a Candida glabrata bloodstream infection. Read More

    Dramatic resolution of disseminated pyoderma gangrenosum associated with monoclonal gammopathy after therapy with bortezomib and dexamethasone.
    Int Wound J 2017 Mar 29. Epub 2017 Mar 29.
    Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain.
    Pyoderma gangrenosum (PG) is an uncommon inflammatory and ulcerative skin disorder, which is commonly associated with systemic conditions such as inflammatory bowel disease, arthritis and haematological malignancies. It is widely stated that control of the underlying diseases may lead to resolution of PG. However, standard of care dictates that patients suffering with monoclonal gammopathy of undetermined significance or smouldering multiple myeloma (MM) should not receive therapy unless they progress to symptomatic MM. Read More

    Autoinflammatory syndromes associated with hidradenitis suppurativa and/or acne.
    Int J Dermatol 2017 Mar 27. Epub 2017 Mar 27.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
    Autoinflammatory syndromes associated with hidradenitis suppurativa (HS) and/or acne are rare but potentially debilitating disorders if not diagnosed and treated correctly. They share a common pathogenesis involving a dysregulated innate immune system with abnormal interleukin (IL)-1 signaling leading to sterile neutrophilic inflammation. The clinical features are recurrent episodes of fever, painful arthritis, and skin lesions consistent with HS, acne, and pyoderma gangrenosum (PG) accompanied by elevated systemic inflammatory markers in blood. Read More

    Successful Treatment of Autoimmune Disease-Associated Pyoderma Gangrenosum With the IL-1 Receptor Antagonist Anakinra: A Case Series of 3 Patients.
    J Clin Rheumatol 2017 Apr;23(3):181-183
    Department of Rheumatology, Princess of Wales Hospital, Bridgend, United Kingdom Department of Dermatology, Princess of Wales Hospital, Bridgend, United Kingdom Department of Dermatology, Neath Port Talbot Hospital, Port Talbot, United Kingdom Department of Rheumatology, Neath Port Talbot Hospital, Port Talbot, United Kingdom Department of Dermatology, Neath Port Talbot Hospital, Port Talbot, United Kingdom Department of Rheumatology, Princess of Wales Hospital, Bridgend, United Kingdom.

    The potential benefits of using aloe vera in stoma patient skin care.
    Br J Nurs 2017 Mar;26(5):S12-S19
    Professor and Director for the Institute of Skin Integrity and Infection Prevention, School of Human and Health Sciences, University of Huddersfield.
    Individuals living with an ostomy may suffer from a variety of peri-stomal skin complications related to the use of their stoma appliance or accessories. These conditions can be serious enough to significantly impact on a patient's quality of life and may result in severe clinical complications (such as infection). This article is a review of the literature with the objective of investigating and presenting evidence for the well-documented use of aloe vera in the prevention of skin conditions similar to those seen in peri-stomal skin complications. Read More

    Pyoderma gangrenosum: clinical characteristics, associated diseases, and responses to treatment in a retrospective cohort study of 31 patients.
    Int J Dermatol 2017 Apr;56(4):386-391
    Chair of Dermatology, Universidad de Buenos Aires, Buenos Aires, Argentina.
    Objective: The aim of this study was to describe the clinical characteristics of patients with pyoderma gangrenosum (PG) and to evaluate the association between these characteristics, the treatment followed, and the patient responses, relapses, and mortality rates.

    Material And Methods: This retrospective cohort study identified adults diagnosed with pyoderma gangrenosum over the duration of 10 years.

    Results: Thirty-one patients were evaluated; 58% were women and 55% were older than 65 years, 87% presented with the ulcerative type, and 77% showed lower limb compromise. Read More

    [Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].
    Ann Dermatol Venereol 2017 May 11;144(5):368-373. Epub 2017 Mar 11.
    Département de dermatologie, grand hôpital de Charleroi (GHDC), Grand'Rue 3, 6000 Charleroi, Belgique.
    Background: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). Read More

    Pyoderma gangrenosum or necrotising fasciitis? Diagnostic and therapeutic wanderings.
    Orthop Traumatol Surg Res 2017 Jun 10;103(4):615-617. Epub 2017 Mar 10.
    Service d'orthopédie-traumatologie, hôpital universitaire de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.
    A case of post-traumatic lower-limb pyoderma gangrenosum (PG) in a 77-year-old female is reported. The diagnosis of PG is frequently one of exclusion, and it is therefore unsurprising that the condition was initially mistaken for necrotising fasciitis then for necrotising bacterial dermo-hypodermitis. Medical and surgical treatment for those conditions proved ineffective. Read More

    [First manifestation of leg ulcers : Analysis of data from 1000 patients].
    Hautarzt 2017 Jun;68(6):483-491
    Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland.
    Background: More than 1 million people in Germany suffer from leg ulcers. The diagnosis leg ulcer summarizes many different etiologies. The therapy of leg ulcers is an interdisciplinary and interprofessional challenge. Read More

    Oral Pyoderma Gangrenosum: Diagnosis, Treatment and Challenges: A Systematic Review.
    Head Neck Pathol 2017 Mar 8. Epub 2017 Mar 8.
    Oral and Maxillofacial Pathologist, Department of Stomatology, Faculty of Dentistry, Universite de Montreal, Montreal, QC, Canada.
    Pyoderma gangrenosum (PG) is a distinctive ulcerative skin disorder of unknown etiology, associated with an underlying systemic disease in up to 70% of cases. The condition is characterized by the appearance of one or more necrotic ulcers with a ragged undermined violaceous border and surrounding erythema. Lesions are often initiated by minor trauma. Read More

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