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    2986 results match your criteria Pyoderma Gangrenosum

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    Comorbidities of pyoderma gangrenosum: a retrospective multicentric analysis of 126 patients.
    Br J Dermatol 2018 Feb 17. Epub 2018 Feb 17.
    Department of Dermatology, Saint Vincent de Paul Hospital, Hospital Group of the Catholic Institute of Lille Lille, France.
    Pyoderma Grangrenosum (PG) is a rare neutrophilic dermatosis with challenging diagnosis and unclear underlying mechanisms. Multifactorial causes are purposed, including neutrophilic dysfunction, aberrant cellular immunity and cytokinic activities, and genetic predispositions. An association with a systemic disease is classically described in 25 to 75% of cases, including inflammatory bowel diseases (IBD), inflammatory rheumatological diseases (IRD) and hematological disorders. Read More

    Successful therapy of Pyoderma gangrenosum with a JAK2 inhibitor.
    Br J Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Dermatology, General Hospital Augsburg, Augsburg, Germany.
    Pyoderma gangrenosum (PG) is a rare, solitary or multiple, chronically progressive, painful, destructive, sterile neutrophil inflammation of unexplained aetiology and pathogenesis, which often remains resistant to treatment. An autoimmunological and autoinflammatory genesis is discussed, which is the main reason why there are so many immunosupressant therapies available. PG may occur in association with inflammatory and haematological disorders, such as Crohn's disease, myeloma, leukaemia, lymphoma and polycythemia vera (PV), as it is the case in our patient presented here. Read More

    The Validity of the Diagnostic Code for Pyoderma Gangrenosum in an Electronic Database.
    Br J Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
    Pyoderma gangrenosum (PG) is a rare inflammatory and ulcerative neutrophilic dermatosis with an estimated incidence of 3-10 cases per million people annually.Given that our understanding of PG is limited by disease rarity and considerable misdiagnosis rates (~30-50%),establishing a method to identify cases in large databases would facilitate population-based research. This approach has been used in other dermatologic diseases,where case identification is performed by diagnosis-related queries based on the International Classification of Diseases (ICD) code. Read More

    Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts.
    JAMA Dermatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Dermatology, University of California, Davis, Sacramento.
    Importance: Pyoderma gangrenosum is a rare inflammatory skin condition that is difficult to diagnose. Currently, it is a "diagnosis of exclusion," a definition not compatible with clinical decision making or inclusion for clinical trials.

    Objective: To propose and validate diagnostic criteria for ulcerative pyoderma gangrenosum. Read More

    The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum.
    JAMA Dermatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Importance: Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis. Current knowledge of this rare disease is limited owing to a lack of validated diagnostic criteria and large population studies.

    Objective: To evaluate the association of age with the clinical presentation and comorbidities of pyoderma gangrenosum. Read More

    Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    Division of Dermatology, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa.
    PASH syndrome (pyoderma gangrenosum, acne, and suppurative hidradenitis) forms part of the spectrum of autoinflammatory diseases. We report an unusual case of PASH syndrome in a patient with end-stagerenal disease (ESRD) who was successfully treated with the tumor necrosis factor inhibitor, adalimumab. The case underscores the challenges associatedwith the treatment of PASH syndrome as well as the ongoing search to establish a genetic basis for the syndrome. Read More

    The impact of underlying disease state on outcomes in patients with pyoderma gangrenosum: A national survey.
    J Am Acad Dermatol 2018 Feb 10. Epub 2018 Feb 10.
    Department of Internal Medicine, Division of Gastroenterology The Ohio State University Wexner Medical Center.
    Background: It is unclear if the underlying disease affects the outcomes in pyoderma gangrenosum.

    Objectives: To determine the impact of comorbid disease associations and concomitant procedural treatments on patient outcomes in PG patient-hospitalizations.

    Methods: A cross-sectional analysis of the Nationwide Inpatient Sample (NIS) for PG patient-hospitalizations from years 2002-2011, analyzing in-hospital mortality rate and health care resource utilization. Read More

    Management of Facial Pyoderma Gangrenosum Using Platelet-Rich Fibrin: A Technical Report.
    J Oral Maxillofac Surg 2018 Jan 31. Epub 2018 Jan 31.
    Associate Professor, School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy. Electronic address:
    This report describes a case of local pyoderma gangrenosum that was treated with short-term immunosuppressive therapy and the topical application of platelet-rich fibrin (PRF). Medical treatment included oral corticosteroid therapy and topical treatment with PRF in solid and liquid form. This therapy initially led to the reduction of the ulcer's size and an improvement in symptoms, until the ulcer was completely healed after a few weeks. Read More

    [When to ask for a skin biopsy in a patient with leg ulcer? Retrospective study of 143 consecutive biopsies].
    J Med Vasc 2018 Feb 21;43(1):4-9. Epub 2017 Nov 21.
    Service de médecine vasculaire, groupe hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75674 Paris cedex 14, France.
    Objective: A vascular cause is found in around 85% of leg ulcer patients, but non-vascular causes are also observed. Their diagnosis is based on a set of clinical arguments and skin biopsy with histological analysis. The aim of this study was to analyze the results of these biopsies and to find common criteria for ulcers whose skin biopsies had led to the diagnosis of a non-vascular ulcer. Read More

    Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis.
    Intest Res 2018 Jan 18;16(1):155-157. Epub 2018 Jan 18.
    Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
    Pyoderma gangrenosum (PG), an ulcerating skin condition, is rare in patients with ulcerative colitis (UC). We report a case of successful treatment of PG in a patient with UC using hyperbaric oxygen therapy (HBOT). The patient had UC that was in remission following treatment with mesalazine and azathioprine therapy. Read More

    Pyoderma gangrenosum: a review of pathogenesis and treatment.
    Expert Rev Clin Immunol 2018 Feb 13:1-9. Epub 2018 Feb 13.
    a Department of Dermatology , Wake Forest School of Medicine , Winston Salem , North Carolina , USA.
    Introduction: Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis that can occur as an idiopathic disease, in association with systemic conditions such as inflammatory bowel disease, as part of an inherited inflammatory syndrome. It can be challenging to treat, as it occurs in a wide variety of clinical settings and there is a lack of a standardized treatment approach. The main limitations to treatment have been an incomplete understanding of the pathogenesis. Read More

    The PARACELSUS score: A novel diagnostic tool for pyoderma gangrenosum.
    Br J Dermatol 2018 Feb 1. Epub 2018 Feb 1.
    Department of Dermatology, Venereology and Allergology, University Hospital of Essen, Germany.
    Background: The lack of objective diagnostic criteria renders pyoderma gangrenosum (PG) a diagnosis of exclusion. The diagnostic approaches proposed to date have not been systematically evaluated. Thus, PG remains a challenging and frequently misdiagnosed disorder. Read More

    gene mutation in a patient with overlapping neutrophilic disease (pyoderma gangrenosum and aseptic abscess syndrome).
    JAAD Case Rep 2018 Mar 16;4(2):120-122. Epub 2018 Jan 16.
    Medicina Interna, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan, Italy.

    Paraneoplastic Pyoderma Gangrenosum Associated with Rectal Adenocarcinoma.
    Ann Dermatol 2018 Feb 26;30(1):79-82. Epub 2017 Dec 26.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Pyoderma gangrenosum (PG) is a rare chronic neutrophilic dermatosis characterized by painful necrotic ulceration. The most common diseases associated with PG are inflammatory bowel disease, certain rheumatologic and hematologic diseases, and malignancy. Here, we describe the case of a 60-year-old man who presented with pruritic and painful erythematous ulcerative macules and patches on both lower extremities, and was diagnosed with PG based on his clinical and histologic features. Read More

    When a wound is the harbinger of a serious underlying systemic illness.
    BMJ Case Rep 2018 Jan 31;2018. Epub 2018 Jan 31.
    Department of Rheumatology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
    A 55-year-old woman presented with progressive enlarging and painful non-healing ulcers on her bilateral lower extremities; biopsy was consistent with pyoderma gangrenosum. Workup for an underlying illness revealed a cavitary lung nodule and an ulcerating mass in the anal canal. Patient did not have any respiratory or gastrointestinal symptoms. Read More

    Classic Ulcerative Pyoderma Gangrenosum Is a T Cell-Mediated Disease Targeting Follicular Adnexal Structures: A Hypothesis Based on Molecular and Clinicopathologic Studies.
    Front Immunol 2017 15;8:1980. Epub 2018 Jan 15.
    Department of Dermatology, University of California, Davis, Sacramento, CA, United States.
    Background: Pyoderma gangrenosum (PG) is a debilitating ulcerative skin disease that is one of the most common associated diseases seen in patients with inflammatory bowel disease and rheumatoid arthritis. Although PG is classified as a neutrophilic dermatosis, its pathophysiology is poorly understood.

    Objective: Use data obtained from patient-reported histories, immunohistochemistry, and gene expression analysis to formulate a hypothesis on PG pathophysiology. Read More

    Skin manifestations of rheumatoid arthritis.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Rheumatoid arthritis is a chronic systemic disease that, in addition to articular involvement, may exhibit a variety of extraarticular manifestations. The skin is frequently involved mainly in the most severe forms of the disease. Rheumatoid nodules, accelerated rheumatoid nodulosis, rheumatoid nodulosis, Felty syndrome, rheumatoid vasculitis, pyoderma gangrenosum, rheumatoid neutrophilic dermatosis, interstitial granulomatous dermatitis, and palisaded neutrophilic granulomatous dermatitis are reviewed both clinically and histologically. Read More

    Neutrophilic dermatoses: a broad spectrum of disease.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Dermatology Unit Ospedale Carlo Urbai Jesi, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -
    The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet's syndrome, neutrophilic dermatosis of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More

    Non-response to Interleukin-1 Antagonist Canakinumab in Two Patients with Refractory Pyoderma Gangrenosum and Hidradenitis Suppurativa.
    J Clin Aesthet Dermatol 2017 Sep 1;10(9):36-38. Epub 2017 Sep 1.
    All authors are with the University of North Carolina at Chapel Hill, Dermatology, in Chapel Hill, North Carolina.
    Pyoderma gangrenosum and hidradenitis suppurativa are skin conditions characterized by an intense neutrophil-mediated inflammatory response that is often difficult to effectively treat. Successful use of interleukin (IL)-1β inhibition using canakinumab and anakinra has been reported in patients with concomitant pyoderma gangrenosum and hidradenitis suppurativa. We report two cases where targeted therapy with canakinumab failed to lead to improvement for patients with pyoderma gangrenosum and hidradenitis suppurativa. Read More

    Pyoderma Gangrenosum-associated Granulomatosis with Polyangitis: A Case Report and Literature Review.
    J Clin Aesthet Dermatol 2017 Oct 1;10(10):40-42. Epub 2017 Oct 1.
    Dr. Zarraga is the chief dermatology resident at Wellington Regional Medical Center in Wellington, Florida.
    Granulomatosis with polyangitis, formerly known as Wegener's granulomatosis, is a multi-system vasculitis that has a variable clinical presentation. Although uncommon, cutaneous symptoms can be the initial presenting symptom of granulomatosis with polyangitis. We present an unusual case of pyoderma gangrenosum followed by a diagnosis of granulomatosis with polyangitis. Read More

    Pyoderma gangrenosum demographics, treatments, and outcomes: an analysis of 2,273 cases.
    J Wound Care 2018 Jan;27(Sup1):S4-S8
    Indiana University School of Medicine, Division of Plastic and Reconstructive Surgery, Indiana University School of Medicine Indianapolis, IN, US; Division of Plastic and Reconstructive Surgery, R.L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN, US.
    Objective: Pyoderma gangrenosum is a rare, neutrophil-mediated, auto-inflammatory dermatosis. This condition has clinical features analogous to infectious processes and must be quickly diagnosed to be properly treated. The purpose of this study was to characterise relevant clinical features associated with pyoderma gangrenosum based on a large inpatient cohort. Read More

    Systemic lupus erythematosus with inflammatory bowel disease-ulcerative colitis: case report.
    Lupus 2018 Jan 1:961203317751857. Epub 2018 Jan 1.
    Internal Medicine Department, Rheumatology Division, 68792 Ain Shams University Hospital , Abbassia, Cairo, Egypt.
    A 30-year-old female presented to the rheumatology outpatient clinic of the Internal Medicine Department, Ain Shams University Hospital, Cairo, Egypt, complaining of a large right leg ulcer consistent with pyoderma gangrenosum. There was history of recurrent attacks of bleeding per rectum of one-year duration. During hospitalization she noticed blurring of vision in the left eye with diffuse blackish discoloration of the feet and toes, consistent with small-vessel vasculitis. Read More

    Postsurgical pyoderma gangrenosum after an autologous stem cell transplantation for multiple myeloma.
    BMJ Case Rep 2018 Jan 5;2018. Epub 2018 Jan 5.
    Department of Infectious Diseases, Universidade de Sao Paulo Faculdade de Medicina, Sao Paulo, Brazil.
    We report a man who underwent autologous stem cell transplantation (ASCT) for multiple myeloma. Two months after ASCT, he presented with necrotising cholecystitis due to gallbladder stones and was submitted to laparoscopic cholecystectomy. About a week later, he developed progressive skin ulcers at sites where trochanters had been inserted. Read More

    Expression of Elafin in Dermatitis Herpetiformis.
    Am J Dermatopathol 2018 Jan;40(1):1-6
    Professor of Dermatology and Dermatopathology, Department of Dermatology, University of Miami, University of Florida, Nova Southeastern University, FL.
    Background: Elafin is a serine protease inhibitor that has various epithelial cell regulatory and immunomodulatory effects including inactivation of neutrophil elastases. This later role originated the interest of elafin in certain neutrophil-rich dermatoses. Interestingly, it has been speculated that elafin has a protective role by slowing the deamidation process of gliadin in celiac disease (CD), despite the typical absence of neutrophils in intestinal histologic samplings. Read More

    Diagnosis and management of peristomal pyoderma gangrenosum: A systematic review.
    J Am Acad Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, University of California, San Francisco - San Francisco, CA. Electronic address:
    Background: Peristomal pyoderma gangrenosum (PPG) is an uncommon subtype of pyoderma gangrenosum. PPG is a challenging condition to diagnose and treat; no evidence-based guidelines exist.

    Objective: To identify important clinical features of PPG and effective treatments available for its management. Read More

    A surgeon's nightmare: pyoderma gangrenosum with pathergy effect mimicking necrotising fasciitis.
    BMJ Case Rep 2017 Dec 20;2017. Epub 2017 Dec 20.
    Department of Orthopaedics and Traumatology, North District Hospital, Hong Kong, China.
    A 53-year-old woman was admitted for vulval swelling and fever. She was initially diagnosed with vulval cellulitis and given parenteral antibiotics. Within 1 week, she developed necrotic-looking skin lesions extending from her vulva to her buttock. Read More

    Pyoderma gangrenosum associated with left iliac vein compression syndrome: presentation of difficult diagnosis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):129-131
    Department of Dermatology at Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-Unifesp) - São Paulo (SP), Brazil.
    Pyoderma gangrenosum is a rare neutrophilic dermatosis of unknown etiology, of which the most frequent clinical manifestations are ulcers. The diagnosis difficulty is, among other things, to rule out other causes of ulcers, since it is considered a diagnosis of exclusion. Skin ulcerations may also occur in the iliac vein compression syndrome, which, like pyoderma gangrenosum, mainly affects young women. Read More

    Pulmonary nodules and nodular scleritis in a teenager with superficial granulomatous pyoderma gangrenosum.
    Pediatr Dermatol 2018 Jan 15;35(1):e35-e38. Epub 2017 Dec 15.
    Dermatology Department, National Institute of Pediatrics, Mexico City, Mexico.
    Superficial granulomatous pyoderma gangrenosum, a rare variant of pyoderma gangrenosum, has been considered to be the most benign form of the disease. We present the case of a 15-year-old boy with pulmonary involvement and nodular scleritis associated with this unusual type of pyoderma gangrenosum and discuss its differential diagnosis. Read More

    Portable negative-pressure wound therapy for pyoderma gangrenosum: Report of two cases.
    J Dermatol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Pyoderma gangrenosum is a chronic non-infectious neutrophilic dermatosis that causes undermining ulcers. Topical therapies for the deep ulcers of pyoderma gangrenosum have not been established. To investigate whether negative-pressure wound therapy is effective for a pyoderma gangrenosum ulcer, we used the PICO single use negative-pressure wound therapy system (Smith & Nephew, London, UK) for two pyoderma gangrenosum patients. Read More

    Acral melanoma foot lesions. Part 2: clinical presentation, diagnosis, and management.
    Clin Exp Dermatol 2018 Mar 13;43(2):117-123. Epub 2017 Dec 13.
    Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
    Acral melanoma (AM) is a rare subtype of cutaneous malignant melanoma found on acral skin, primarily on the soles of the feet. Although rare, it is the most common subtype of melanoma found in patients of African or Asian ethnicity and has a poor prognosis, often because of the more advanced stage of presentation at diagnosis. In the second of this two-part series, we review the clinical presentation, histopathology, diagnosis and management of AM. Read More

    Erosive pustular dermatosis of the scalp: reappraisal of an underrecognized entity.
    J Dtsch Dermatol Ges 2018 Jan 12;16(1):15-19. Epub 2017 Dec 12.
    Department of Dermatology & Venereology, Medical University Innsbruck, Innsbruck, Austria.
    Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory dermatosis of unknown etiology. Herein, we present a review of the disease and report our own clinical and histopathological experience in eleven patients. EPDS tends to spontaneously affect bald areas of the scalp in elderly individuals. Read More

    Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen.
    Clin Case Rep 2017 Dec 31;5(12):2025-2027. Epub 2017 Oct 31.
    Department of Hematology and OncologyTaussig Cancer InstituteCleveland ClinicClevelandOhio.
    Pyoderma gangrenosum (PG) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat underlying myeloid malignancy causing PG, to thereby produce safe and effective resolution of extensive PG. Read More

    [Recurrent postpartum pyoderma gangrenosum and fatal cardiomyopathy].
    Ann Dermatol Venereol 2017 Dec 6. Epub 2017 Dec 6.
    Service de dermatologie et vénérologie, faculté de médecine et de pharmacie, université Mohammed V, centre hospitalier universitaire Ibn Sina, BP 6527, 10100 Rabat, Maroc.
    Background: We report a case of recurrent post-partum pyoderma gangrenosum (PG) complicated by post-partum cardiomyopathy (PPCM).

    Patients And Methods: A 23-year-old woman presented with a previous medical history of aseptic abscess of the left breast in her fourth pregnancy, which developed after surgical drainage of an inflammatory ulceration treated by atraumatic topical care. During her fifth pregnancy, the patient presented a large and painful ulceration in relation to the scar of the Caesarean section, despite the introduction of broad-spectrum antibiotic therapy. Read More

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