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    2924 results match your criteria Pyoderma Gangrenosum

    1 OF 59

    The expanding spectrum of clinical phenotypes associated with PSTPIP1 mutations: from PAPA to PAMI syndrome and beyond.
    Br J Dermatol 2017 Nov 18. Epub 2017 Nov 18.
    Department of Dermatology, University Hospital Bern, Freiburgstrasse 10, 3010, Bern, Switzerland.
    Mutations in the PSTPIP1 gene encoding proline-serine-threonine-phosphatase interactive protein 1 were first identified in an autosomal dominant syndrome called PAPA associated with pyogenic sterile arthritis, pyoderma gangrenosum (PG) and cystic acne.(1,2) . We report a patient with an autoinflammatory syndrome called PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome. Read More

    Vanishing vasculitis: a case of acute necrotic skin findings without pathologic features of vasculitis from adulterated cocaine.
    J Community Hosp Intern Med Perspect 2017 18;7(5):321-324. Epub 2017 Oct 18.
    Internal Medicine Residency Program, St. Elizabeth Youngstown Hospital, Youngstown, OH, USA.
    While the usage of illicit drugs in itself carries significant health risks and associated toxicities, drugs that are adulterated to give them volume, alter their psychogenic properties, and make them cheaper to produce are to be considered even more dangerous. Cocaine is one of them, and it is now most commonly being adulterated with levamisole. We report a case of a 37-year-old female with the chief complaint of painful skin lesions and wounds on both of her upper and lower extremities for three weeks duration. Read More

    Pyoderma Gangrenosum: A Critical Appraisal.
    Adv Skin Wound Care 2017 Dec;30(12):534-542
    Eran Shavit, MD • Dermatologist, Clinical Fellow • Division of Dermatology, Department of Medicine • Women's College Hospital, University of Toronto • Toronto, Ontario, Canada Afsaneh Alavi, MD, MSc, FRCPC • Assistant Professor • Division of Dermatology, Department of Medicine • Women's College Hospital, University of Toronto • Toronto, Ontario, Canada R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med)(Derm), FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Clinical Editor • Advances in Skin & Wound Care • Philadelphia, Pennsylvania.
    General Purpose: To provide information about pyoderma gangrenosum (PG), including pathophysiology, diagnostic criteria, and treatment.

    Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

    Learning Objectives/outcomes: After participating in this educational activity, the participant should be better able to: ABSTRACT: Pyoderma gangrenosum (PG) is an uncommon cutaneous disease, presenting with recurrent painful ulcerations most commonly on the lower extremities. Read More

    Pyoderma Gangrenosum: The Great Impostor.
    Adv Skin Wound Care 2017 Dec;30(12):533
    Richard "Sal" Salcido, MD, EdD, is the Editor-in-Chief of Advances in Skin & Wound Care; the William Erdman Professor, Department of Physical Medicine and Rehabilitation; Senior Fellow, Institute on Aging; and Associate, Institute of Medicine and Bioengineering, at the University of Pennsylvania Health System, Philadelphia, Pennsylvania.

    Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum.
    Chin Med J (Engl) 2017 Nov;130(22):2674-2679
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
    Background: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is highly associated with inflammatory bowel disease (IBD). Certain PG patients with no systemic disorders have been diagnosed with idiopathic PG. This study sought to clarify the difference between PG with IBD and idiopathic PG based on clinical features, laboratory tests, and medications. Read More

    Paradoxical Reactions: Anti-Tumor Necrosis Factor Alpha Agents, Ustekinumab, Secukinumab, Ixekizumab, and Others.
    Curr Probl Dermatol 2018 7;53:49-63. Epub 2017 Nov 7.
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease. Paradoxical reactions have subsequently been reported with other biological drugs or classes (e. Read More

    Clinical Disease Patterns in a Regional Swiss Cohort of 34 Pyoderma Gangrenosum Patients.
    Dermatology 2017 Nov 7. Epub 2017 Nov 7.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Background/aim: Pyoderma gangrenosum (PG) is a rare, neutrophilic dermatosis often associated with an underlying disease, and clinical data or larger studies are rare.

    Methods: In this retrospective study, disease characteristics, clinical manifestations, and treatment response were evaluated in a Swiss cohort of PG patients.

    Results: In participating centers, 34 cases (21 females) of PG were analyzed based on clinical and histological presentation between 2002 and 2012. Read More

    Generating new evidence, improving clinical practice and developing research capacity: the benefits of recruiting to the U.K. Dermatology Clinical Trials Network's STOP GAP and BLISTER trials.
    Br J Dermatol 2017 Nov 10. Epub 2017 Nov 10.
    Centre of Evidence Based Dermatology, King's Meadow Campus, Lenton Lane, Nottingham, NG7 2NR, U.K.
    Clinical trials may benefit clinical practice in three ways: firstly, clinicians may change their practice according to the new trial evidence; secondly, clinical processes can improve when working on a trial; and thirdly, research capacity is increased. We held a meeting to present and discuss the results of two large multicentre randomized controlled trials delivered through the U.K. Read More

    Pyoderma gangrenosum after orthopaedic or traumatologic surgery: a systematic revue of the literature.
    Int Orthop 2017 Nov 8. Epub 2017 Nov 8.
    Orthopaedic and Traumatologic Department, La Meynard University Hospital, CS 90632, 97261, Fort-de-France, Martinique.
    Introduction: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterised by a painful ulceration mimicking infection of the operative site. To this day, there is still no general agreement on the medical and surgical treatment of PG. This systematic review of the literature aims to summarise recent studies about post-operative PG in orthopaedic surgery to improve its medical and surgical management. Read More

    Pyoderma gangrenosum of the lip involving the oral cavity: a case report and literature review.
    Eur J Dermatol 2017 Oct;27(5):551-552
    Department of Dermatology, Chonbuk National University Medical School,, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

    Pyoderma gangrenosum and pyogenic arthritis presenting as severe sepsis in a rheumatoid arthritis patient treated with golimumab.
    Rheumatol Int 2017 Oct 26. Epub 2017 Oct 26.
    4th Department of Internal Medicine, Hippokration University Hospital, Medical School, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Str, 54642, Thessaloniki, Greece.
    Rheumatoid arthritis is a systemic autoimmune disease resulting in joint destruction and deformities, but also associated with extraarticular and systemic manifestations. The later devastating conditions, such as the development of rheumatoid vasculitis, are more frequently encountered in seropositive patients and their incidence has been attenuated after the introduction of biologic disease modifying drugs, such as anti-tumor necrosis factor alpha (TNFa) agents, which generally have considerably contributed to the better control and long-term outcomes of the disease. Interestingly, autoimmune syndromes may, rarely, present in patients without a positive history after the initiation of treatment. Read More

    The Safety of Treatments Used in Pyoderma Gangrenosum.
    Expert Opin Drug Saf 2017 Oct 25. Epub 2017 Oct 25.
    a Wake Forest School of Medicine - Dermatology, Pathology, and Public Health Sciences.
    Introduction: Pyoderma gangrenosum (PG) is a severe ulcerating orphan dermatosis characterized by painful and rapidly progressive skin ulcers often associated with underlying inflammatory disease. Areas covered: In this article, we review and analyze the literature regarding treatment options for patients with PG, with particular attention to the efficacy and safety of therapies. Despite the significance of this problem, there are few studies devoted to the efficacy or safety of therapeutics in PG. Read More

    An Unusual Presentation of Pyoderma Gangrenosum Leading to Systemic Inflammatory Response Syndrome.
    Case Rep Dermatol 2017 Sep-Dec;9(3):146-150. Epub 2017 Sep 11.
    Department of Dermatology, Fiona Stanley Hospital, Murdoch, Washington, Australia.
    This is a report of an atypical presentation of pyoderma gangrenosum (PG) in a 26-year-old male who had a negative septic screen. The patient had a life-threatening presentation requiring an intensive care unit (ICU) admission for vasopressor support. It was thought that the likely cause of circulatory collapse was an overwhelming cytokine reaction or systemic inflammatory response syndrome (SIRS) secondary to extensive PG lesions rather than septic shock. Read More

    [Scedosporium apiospermum skin infection mimicking a pyoderma gangrenosum].
    Med Mal Infect 2017 Oct 11. Epub 2017 Oct 11.
    Médecine interne et maladie infectieuse, CH Manchester, 45, avenue de Manchester, 08000 Charleville-Mézières, France; Médecine interne, maladie infectieuse et immunologie clinique, hôpital Robert Debré, CHU de Reims, rue du Général-Koenig, 51100 Reims, France. Electronic address:

    [Pyoderma gangraenosum after implantation of a shoulder endoprothesis].
    Orthopade 2017 Nov;46(11):963-968
    II. Orthopädische Abteilung, Herz-Jesu Krankenhaus Wien, Baumgasse 20A, 1030, Wien, Österreich.
    Pyoderma gangrenosum is an inflammatory, ulcerative, neutrophilic dermatosis that is clinically characterized by rapidly evolving, painful, necrotic skin lesions. It is typically associated with chronic systemic inflammatory or neoplastic diseases, but may also occur secondary to cutaneous injury or surgery (pathergy). Post-surgical pyoderma gangrenosum typically develops around surgical sites within the immediate postoperative period, mimicking early wound infection. Read More

    Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review.
    Clin Rev Allergy Immunol 2017 Dec;53(3):394-412
    Dermatologia Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland.
    Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. Read More

    An interesting case of pyoderma gangrenosum with immature hystiocytoid neutrophils.
    J Cutan Pathol 2017 Oct 5. Epub 2017 Oct 5.
    Department of Pathology, Notre-Dame Hospital, University of Montreal, Montreal, Quebec, Canada.
    We present a unique case of a 36-year-old male who developed more than 20 pyoderma gangrenosum (PG) ulcers showing on histopathology a dense inflammatory infiltrate composed of histiocytoid mononuclear immature cells with a strong positivity for myeloperoxidase and Leder stain, suggesting a myeloid lineage in the absence of a concomitant myeloproliferative disorder. Histiocytoid Sweet syndrome (SS) is now recognized as a histological subtype of SS. Although PG and SS belong to the spectrum of neutrophilic diseases, to the best of our knowledge, this is the first case of a "Histiocytoid pyoderma gangrenosum" encompassing immature granulocytes in the absence of leukemia cutis. Read More

    Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases.
    World J Gastroenterol 2017 Sep;23(33):6137-6146
    Department of Medical Gastroenterology S, Odense University Hospital, 5000 Odense, Denmark.
    Aim: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD).

    Methods: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. Read More

    Risk of developing pyoderma gangrenosum after procedures in patients with a known history of pyoderma gangrenosum-a retrospective analysis.
    J Am Acad Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: The risk of postoperative pyoderma gangrenosum (PG) in patients with a known history of PG is unknown.

    Objective: To quantify risk and identify patient- and/or procedure-related risk factors for postsurgical recurrence or exacerbation of PG in patients with a known history of PG.

    Methods: We retrospectively evaluated the likelihood of postsurgical recurrence or exacerbation of PG for all patients with a confirmed diagnosis of PG at Brigham and Women's Hospital and Massachusetts General Hospital from 2000 to 2015. Read More

    Extensive Pyoderma Gangrenosum: A Challenging Diagnosis and Literature Review of Management.
    Cureus 2017 Jul 18;9(7):e1486. Epub 2017 Jul 18.
    Internal Medicine, Nawaz Sharif Medical College, University of Gujrat.
    Pyoderma gangrenosum is a very rare, non-infectious leukocytic dermatosis, which is often associated with an underlying systemic disease. It is usually diagnosed based on the apparent clinical findings and by excluding other causes of ulcerative skin diseases. Treatment modality includes the use of systemic steroids and oral steroids. Read More

    Pyoderma Gangrenosum: An Uncommon Case Report and Review of the Literature.
    Wounds 2017 Sep;29(9):E61-E69
    Serviço de Cirurgia 1, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
    Background: Pyoderma gangrenosum (PG) is a rare ulcerative condition that is diagnostically and therapeutically challenging, as debridement leads to ulcer deterioration (pathergy phenomenon); immunosuppression is considered the gold standard therapy.

    Case Report: The authors present the case of a 42-year-old woman with PG and uncontrolled iatrogenic diabetes, secondary to a total pancreatectomy performed in another hospital in 1998 due to nesidioblastosis. In 2008, she was referred to the diabetic foot consultation at Centro Hospitalar Tondela-Viseu (Viseu, Portugal) due to an infected wound on the left leg thought to be related to a trauma from footwear, but the injury worsened despite treatment. Read More

    Reconstructive microsurgical approach for the treatment of pyoderma gangrenosum.
    J Plast Reconstr Aesthet Surg 2017 Aug 16. Epub 2017 Aug 16.
    Department of Plastic, Aesthetic and Reconstructive Surgery, Hospital Barmherzige Brüder Salzburg, Paracelsus Medical University (PMU), Kajetanerplatz 1, 5020, Salzburg, Austria.
    Introduction: Pyoderma gangrenosum (PG) is a rare type of autoimmune disease that results in progressive ulcers with or without previous trauma. However, PG is not well understood to date, and its treatment therefore remains a challenge. Because of the disease's systemic characteristic and the unpredictability of the clinical course, no gold standard treatment is available, especially concerning the surgical procedures to treat pyodermic lesions. Read More

    Clinical and pathological significance of cutaneous manifestations in ANCA-associated vasculitides.
    Autoimmun Rev 2017 Nov 14;16(11):1138-1146. Epub 2017 Sep 14.
    Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address:
    Objectives: Cutaneous manifestations (CM) in ANCA-associated vasculitides (AAV) are frequent, but data on clinical significance and clinical-pathological correlations are lacking.

    Methods: We conducted a multicenter, retrospective study including 1553 AAV patients. Clinical, biological and pathological features have been analyzed, and tissue samples from 46 biopsies were reviewed in a blind manner. Read More

    Pyoderma Gangrenosum: A Current Problem as Much as an Unknown One.
    Int J Low Extrem Wounds 2017 Sep 6;16(3):191-201. Epub 2017 Jun 6.
    2 Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
    Pyoderma gangrenosum (PG) is a rare neutrophilic inflammatory skin disease, characterized by recurrent skin ulcers, which in almost 50% of cases are associated with systemic autoimmune disorders, including rheumatoid arthritis, chronic hepatitis, inflammatory bowel disease, paraproteinemias and hematological malignancies. A systematic search of literature for PG was carried out using the PubMed, Embase, and Google Scholar databases for the purpose of this review and 2780 articles were retrieved up to February 2017. Inflammation represents the predominant aspect of the disease, but its pathophysiological mechanisms are not completely clear yet, since there are many studies showing only one or more isolated findings of the disease. Read More

    Granulomatosis with Polyangiitis Presenting with Pyoderma Gangrenosum-Like Ulceration and Negative Cytoplasmic Antineutrophilic Cytoplasmic Antibodies in a Child.
    Pediatr Dermatol 2017 Sep;34(5):e231-e234
    Geisinger Health System, Danville, Pennsylvania.
    Granulomatosis with polyangiitis (GPA), a vasculitis that most commonly affects small to medium-size vessels of the respiratory tract and kidneys, may also present with a wide array of skin findings. We present the case of a 12-year-old boy with pyoderma gangrenosum-like ulcerations on his lower extremity as the initial manifestation of GPA despite negative cytoplasmic antineutrophilic cytoplasmic antibodies (c-ANCAs). Although GPA is strongly associated with c-ANCA, c-ANCA may be negative on presentation. Read More

    SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature.
    Int J Dermatol 2017 Sep 7. Epub 2017 Sep 7.
    Ingham Institute of Applied Medical Research, Liverpool, Sydney, Australia.
    SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare inflammatory condition describing the combination of skin, bone, and joint manifestations that has a heterogeneous presentation. We report a case of severe SAPHO syndrome in association with hidradenitis suppurativa and pyoderma gangrenosum in a 27-year-old male. The patient had an initial migratory arthritis affecting the knees, ankles, metacarpophalangeal joints, proximal interphalangeal joints, wrists, shoulder, and lower back, which progressed to a persistent arthritis and swelling at the sternum, shoulders, wrists, hands, feet, and lower back. Read More

    Evaluation of osteopontin expression in chronic wounds: a potential prognostic and therapeutic biomarker.
    J Wound Care 2017 Sep;26(Sup9):S4-S8
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, US.
    Objective: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. Read More

    Pyoderma Gangrenosum after Breast Mastectomy and Primary Rectus Abdominis Flap Reconstruction.
    Tokai J Exp Clin Med 2017 Sep 20;42(3):133-138. Epub 2017 Sep 20.
    Division of Breast and Endocrine Surgery, Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
    Pyoderma gangrenosum is an intractable disease of unknown cause involving recurrent ulcerative lesions on the skin, and may accompany ulcerative colitis, rheumatoid arthritis, leukemia, systemic lupus erythematosus, and other conditions. Here, we report a rare case of pyoderma gangrenosum in the thoracic abdomen following post-mastectomy reconstructive surgery. A 39-year-old presented at the hospital with a complaint of left papilla erosion. Read More

    [Vitamin K antagonist-induced necrotic leg ulcer, without protein C and S deficiencies].
    Rev Med Interne 2017 Aug 31. Epub 2017 Aug 31.
    Service de dermatologie, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prudhon, 95100 Argenteuil, France.
    Introduction: Patients treated by vitamin K antagonists (VKA) represent 1% of the population in France. We report a case of atypical necrotic leg ulcers induced by VKA.

    Case Report: A 84-year-old woman was referred to our dermatology department because of necrotic leg ulcers that developed for the past 5weeks, and appeared spontaneously after the introduction of a VKA, fluindione. Read More

    Pyoderma gangrenosum affecting the eye, orbit, and adnexa. A review.
    Orbit 2017 Sep 1:1-6. Epub 2017 Sep 1.
    a Ophthalmology Department Mater Misericordiae University Hospital , Dublin , Ireland.
    While pyoderma gangrenosum (PG) most commonly affects the skin it can also involve other organs. It rarely affects the eye, orbit, or adnexa. Its early recognition and proper management with prompt initiation of immunosuppressive therapy are essential for the preservation of the eye and, in turn, vision, in these cases. Read More

    Comparison of pyoderma gangrenosum and hypertensive ischemic leg ulcer Martorell in a Swiss cohort.
    Br J Dermatol 2017 Aug 20. Epub 2017 Aug 20.
    Department of Dermatology, Venerology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
    Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis presenting with painful and sterile skin ulcerations (1). Its aetiology remains largely unknown although an autoinflammatory background seems possible. Several comorbidities as well as triggering factors such as surgery, trauma or pharmacological therapies have been associated with the development of PG (2). Read More

    Topical Medical Cannabis: A New Treatment for Wound Pain-Three Cases of Pyoderma Gangrenosum.
    J Pain Symptom Manage 2017 Nov 14;54(5):732-736. Epub 2017 Aug 14.
    Department of Family & Community Medicine, University of Toronto, Toronto, Ontario, Canada.
    Pain associated with integumentary wounds is highly prevalent, yet it remains an area of significant unmet need within health care. Currently, systemically administered opioids are the mainstay of treatment. However, recent publications are casting opioids in a negative light given their high side effect profile, inhibition of wound healing, and association with accidental overdose, incidents that are frequently fatal. Read More

    Pyoderma gangrenosum in a patient with chronic granulomatous disease: A case report.
    Medicine (Baltimore) 2017 Aug;96(31):e7718
    1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Rationale: The simultaneous occurrence of pyoderma gangrenosum (PG) and chronic granulomatous disease (CGD) is uncommon and few cases have been reported worldwide.

    Patient Concerns: PG is a rare, chronic, ulcerative, neutrophilic skin disease of unknown etiology that requires immunosuppressive treatment. CGD belongs to Primary Immune Deficiencies in which the main defect lies in an inability of the phagocytic cells to generate superoxide making patients susceptible to serious, potentially life-threatening bacterial and fungal infections. Read More

    Skin diseases of the vulva: inflammatory, erosive-ulcerating and apocrine gland diseases, zinc and vitamin deficiency, vulvodynia and vestibulodynia.
    J Obstet Gynaecol 2017 Aug 1:1-12. Epub 2017 Aug 1.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described. Read More

    Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia.
    Ann Dermatol 2017 Aug 21;29(4):476-478. Epub 2017 Jun 21.
    Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, China.
    X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder caused by germline mutations of B-cell tyrosine kinase (BTK) gene. It is characterized by decreased serum immunoglobulins levels and circulating mature B cells. This defect in humoral immunity leads to increased susceptibility to infection. Read More

    Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides.
    Clin Rev Allergy Immunol 2017 Dec;53(3):371-393
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients. Several cutaneous manifestations have been related to rheumatoid arthritis such as subcutaneous nodules including classical rheumatoid nodules, accelerated rheumatoid nodulosis, and rheumatoid nodulosis; vascular disorders like rheumatoid vasculitis, livedo racemosa, and Raynaud's phenomenon; and neutrophilic and/or granulomatous diseases like pyoderma gangrenosum, Sweet's syndrome, rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with arthritis, as well as palisaded neutrophilic and granulomatous dermatitis. Read More

    Intravenous Immunoglobulin as Adjunct Therapy for Refractory Pyoderma Gangrenosum: Systematic Review of Cases and Case Series.
    Br J Dermatol 2017 Jul 25. Epub 2017 Jul 25.
    Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
    Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis. Treatment regimens for refractory cases are non-standardized. Intravenous immunoglobulin (IVIG) is an emerging treatment with reported success, but the efficacy of IVIG for PG is unknown. Read More

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