3,910 results match your criteria Pyoderma Gangrenosum


Management of Idiopathic Pyoderma Gangrenosum With Azathioprine As the Primary Adjunct in an Asian Man: A Case Report.

Cureus 2022 May 21;14(5):e25177. Epub 2022 May 21.

Medicine, Jinnah Hospital, Allama Iqbal Medical College, Lahore, PAK.

Pyoderma gangrenosum (PG) is a very rare, non-infectious, progressive inflammatory condition falling under the umbrella of neutrophilic dermatoses. It is an ulcerative condition with a wide variety of cutaneous manifestations and multiple clinical variants (classic ulcerative, pustular, bullous, and superficial granulomatous). Additionally, owing to similar patterns of mucocutaneous ulceration, it has certain overlaps with other neutrophilic diseases frequently observed in clinical practice. Read More

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A Case of Recurrent Idiopathic Pyoderma Gangrenosum.

Cureus 2022 May 18;14(5):e25112. Epub 2022 May 18.

Internal Medicine, Department of Medicine, Hospital Pedro Hispano, Matosinhos Local Health Unit, Matosinhos, PRT.

Pyoderma gangrenosum (PG) is a rare chronic neutrophilic dermatosis that can be associated with underlying conditions, such as inflammatory bowel disease and neoplasms, or can be idiopathic. Classically, it presents as painful skin lesions. We present a case of a 54-year-old woman who got a synovial cyst removed from her left hand, which later aggravated into a non-healing wound, and subsequently a painful necrotic ulcer. Read More

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Pyoderma gangrenosum after deep inferior epigastric perforator flap: How prompt diagnosis and treatment can avoid surgical debridement and further morbidity.

JPRAS Open 2022 Sep 16;33:42-46. Epub 2022 May 16.

Department of Surgery, Division of Plastic Surgery - Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX, United States.

Pyoderma gangrenosum (PG) is a skin disorder characterized by painful, enlarging necrotic ulcers with bluish borders surrounded by advancing zones of erythema. The key histologic feature is neutrophilic infiltration of the superficial and deep layers of the dermis and the absence of microorganisms. Although rare and associated with autoimmune diseases such as rheumatoid arthritis, ulcerative colitis and Crohn's disease, the diagnosis is commonly missed at presentation and patients are often treated for infection with antibiotics and surgical debridement. Read More

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September 2022

Bullous Variant of Pyoderma Gangrenosum in a Patient with Acute Myeloid Leukemia.

Ann Dermatol 2022 Jun 20;34(3):212-215. Epub 2022 May 20.

Department of Dermatology, Gyeongsang National University School of Medicine, Jinju, Korea.

Unlike classic pyoderma gangrenosum (PG), the bullous variant of PG is typically represented by a painful erythematous papule, plaque, and superficial bulla that progress into the ulceration with bullous margin. Generally, bullous PG is most commonly associated with myeloproliferative disorders, such as acute myeloid leukemia (AML). Bullous PG in AML patients rarely occurs, but once it does, it suggests a poor clinical prognosis. Read More

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Systemic pyoderma gangrenosum resulting in splenectomy: a cautionary case.

Intern Med J 2022 Jun;52(6):1097-1098

Department of Dermatology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

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Neutrophilic Dermatoses in a Clinical Practice of Wound Care Professionals.

Adv Skin Wound Care 2022 Jun;35(6):1-8

Tatiana Lapa, MD, MScCH, is Master's Student, Dalla Lana School of Public Health, University of Toronto, Clinical Practicum Placement, Toronto Regional Wound Healing Clinic, International Interprofessional Wound Care Course, Toronto, Ontario, Canada. R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med Derm), MACP, FAAD, MAPWCA, is Professor, Division of Dermatology, Department of Medicine, and Dalla Lana School of Public Health, University of Toronto, and Women's College Hospital, Toronto. Patricia M. Coutts, RN, is Wound Care & Clinical Trials Coordinator, Toronto Regional Wound Healing Clinic and Faculty, International Interprofessional Wound Care Course. Xiu Chang Zhao, MD, CCFP, is Family Physician, Trillium Health Partners, Mississauga, Ontario. The authors have disclosed no financial relationships related to this article. Submitted June 7, 2021; accepted in revised form July 26, 2021.

Abstract: Diagnosing and treating neutrophilic dermatoses (NDs) in clinical practice can be challenging because of various presentations and stubborn treatment responses. Establishing a diagnosis is necessary, though, because many NDs are associated with underlying conditions, including malignancy. In this article, the authors provide information about Sweet syndrome, pyoderma gangrenosum, and other NDs and describe their clinical presentation, pathophysiology, diagnostic criteria, and associated conditions. Read More

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Get It Off Your Chest: A Narrative Review of Breast Ulcers.

Adv Skin Wound Care 2022 Jun;35(6):306-313

General Purpose: To provide comprehensive information about breast ulcers to facilitate accurate diagnosis and treatment of these lesions.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant will:1. Read More

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A Case of Overlapping Clinical Features of Idiopathic Granulomatous Mastitis, Hidradenitis Suppurativa, and Pyoderma Gangrenosum Successfully Treated with Adalimumab.

Case Rep Dermatol 2022 May-Aug;14(2):98-106. Epub 2022 May 3.

Department of Dermatovenerology, University Medical Centre Maribor, Maribor, Slovenia.

A 36-year-old woman with a 6-month history of painful unilateral mammary nodules and abscesses was initially treated by gynecologists under the diagnosis of idiopathic granulomatous mastitis (IGM). IGM is an entity that has not been described in classical dermatological textbooks and is considered a rare inflammatory breast disease assumingly associated with trauma, infection, or autoimmune system manifestations. In this patient, the lesions were refractory to conventional treatment of IGM comprising of surgical incisions, systemic antibiotics, dexamethasone, and methotrexate. Read More

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Cough and Progressive Pleuritic Chest Pain With an Enlarging Cavity on Imaging.

Chest 2022 Jun;161(6):e349-e354

Department of Pulmonary and Critical Care, Zucker School of Medicine at Lenox Hill Hospital, New York, NY.

Case Presentation: A 49-year-old woman sought treatment at the hospital for evaluation of an enlarging cavitary mass of the right lung associated with worsening ipsilateral pleuritic chest pain and cough. She had recent hospitalizations for complications relating to recurrent lung abscesses, including one in which she underwent wedge resection of the right lung. She had been treated with several courses of antibiotics, which only temporarily relieved her symptoms. Read More

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Pyoderma Gangrenosum as Differential Diagnosis to Post-Operative Infection after Breast Plastic Surgery.

Surg Infect (Larchmt) 2022 Jun 1. Epub 2022 Jun 1.

Infectious Disease Department, Nord Franche-Comté Hospital, Trevenans, France.

is a scarce ulcerating inflammatory skin disease, which requires excluding other causes of ulceration such as infections, malignancies or connective tissue diseases. We report the case of a 38-year-old woman who developed a progressive bilateral breast skin ulcer after breast plastic surgery, suspected initially with an early postoperative infection. The lack of improvement despite adequate antimicrobial drugs conducted to perform a skin biopsy, concluding to an ulcerated neutrophil dermatosis which led to the diagnosis of postoperative . Read More

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Aseptic Abscess Syndrome With Ulcerative Colitis and Pyoderma Gangrenosum.

Clin Gastroenterol Hepatol 2022 May 25. Epub 2022 May 25.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

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Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments.

Am J Clin Dermatol 2022 May 24. Epub 2022 May 24.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, 20122, Milan, Italy.

Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of neutrophilic dermatoses and clinically characterized by painful, rapidly evolving cutaneous ulcers with undermined, irregular, erythematous-violaceous edges. Pyoderma gangrenosum pathogenesis is complex and involves a profound dysregulation of components of both innate and adaptive immunity in genetically predisposed individuals, with the follicular unit increasingly recognized as the putative initial target. T helper 17/T helper 1-skewed inflammation and exaggerated inflammasome activation lead to a dysregulated neutrophil-dominant milieu with high levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-1α, IL-8, IL-12, IL-15, IL-17, IL-23, and IL-36. Read More

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Primary cutaneous B cell lymphoma, leg type presenting as a diabetic ulcer: A challenging diagnosis.

Pathol Res Pract 2022 Jul 11;235:153940. Epub 2022 May 11.

Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy. Electronic address:

Introduction: A crescent number of reports describe malignant dermal malignancies presenting as diabetic ulcers, such as melanoma, Kaposi's sarcoma, squamous cell carcinoma and cutaneous lymphoma.

Methods: The authors reported the clinical and histopathological features of this challenging case of a PCBCL, leg type presenting as a foot ulcer to exemplify the diagnostic difficulties, mainly when, at the onset, this tumour exhibits uncharacteristic features.

Case Report: A 43 years-old male with a 10-year history of compensated type I diabetes developed an ulcerated 3 cm of diameter tumour on the lateral region of the right foot. Read More

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COVID-19 infection and treatment-resistant cocaine-induced pyoderma gangrenosum: A case report.

Ann Med Surg (Lond) 2022 Jun 18;78:103828. Epub 2022 May 18.

Department of Internal Medicine, University of Texas Rio Grande Valley, Valley Baptist Medical Center, Harlingen, TX, USA.

Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis of non-infectious etiology. Cocaine-induced PG (CIPG) is a documented clinical variant.

Case Presentation: We report an exceptional case of cocaine-induced PG flare unresponsive to conventional treatment in the context of positive COVID status. Read More

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Cutaneous manifestations of antineutrophil cytoplasmic antibody-associated vasculitis (AAV): a concise review with emphasis on clinical and histopathologic correlation.

Int J Dermatol 2022 May 22. Epub 2022 May 22.

Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises a group of small vessel vasculitides grouped by commonalities of clinical manifestations and ANCA testing. Skin findings are not uncommon, although there is considerable overlap and many times nonspecificity. In general, patients with skin findings tend to have more significant systemic illness, and skin lesions most often develop simultaneously or following onset of systemic symptoms. Read More

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Squamous cell carcinoma of verrucous type in the setting of prior pyoderma gangrenosum: a case report.

J Med Case Rep 2022 May 23;16(1):199. Epub 2022 May 23.

Orlando VA Medical Center, Orlando, USA.

Introduction: Pyoderma gangrenosum and cutaneous squamous cell carcinoma are two conditions well reported in the literature and may exist concurrently in the same patient. In fact, there have been reports of misdiagnosis of one for the other. The two conditions occurring in the same location, however, has not yet been reported. Read More

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"Pyoderma gangrenosum - a lifelong chronic disease. A 10 year clinical follow up of a pyoderma patient".

J Plast Reconstr Aesthet Surg 2022 May 10. Epub 2022 May 10.

Department of Dermatology and Allergology, University Hospital Salzburg, Paracelsus Medical University, Muellner-Hauptstrasse 48, 5020, Salzburg, Austria.

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Pyoderma gangrenosum following vaccination against coronavirus disease-2019: a case report.

Int J Dermatol 2022 07 14;61(7):905-906. Epub 2022 May 14.

Department of Dermatology, Jichi Medical University, Shimotsuke city, Japan.

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Next-Generation Sequencing Analysis of MVK, NLRP3, TNFRSF1A, and PSTPIP1 Genes in Patients without MEFV Gene Variation and Genotype-Phenotype Correlation.

Eur J Rheumatol 2022 04;9(2):62-67

Department of Pediatrics, Divisionof Molecular Biology, Ege University School of Medicine, İzmir, Turkey.

Objective: In this study, we aimed to evaluate other interleukin-1b-mediated monogenic autoinflam- matory diseases (AIDs) (tumor necrosis factor receptor-1-associated periodic syndrome, hyperimmuno- globulin D syndrome, cryopyrin-associated periodic syndrome (CAPS), pyogenic arthritis, pyoderma gangrenosum, and acne syndrome) by the next-generation sequencing method (NGS) in cases with clinical Familial Mediterranean Fever symptoms, and no variant detected in the MEFV gene. Methods: The cases included in this study and their parents were interviewed and filled in a survey form. The targeted genetic panel for interleukin-1b-mediated AIDs covering four genes (MVK, NLRP3,TNFRSF1A, and PSTPIP1) was studied for cases with a negative result from the MEFV gene analysis. Read More

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Pyoderma Gangrenosum-like Skin Ulceration in ANCA-associated vasculitis: A Retrospective Case Series.

Clin Exp Dermatol 2022 May 7. Epub 2022 May 7.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

ANCA-associated vasculitis (AAV) can be associated with various cutaneous manifestations. Several case reports have described skin ulceration resembling pyoderma gangrenosum (PG), particularly in granulomatosis with polyangiitis (GPA), however, the true incidence is unknown. In addition, PG is frequently misdiagnosed, and diagnosis may rely on exclusion of other causes of ulcers. Read More

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Noninfectious sternal wound inflammation after coronary artery bypass grafting in a patient with myelodysplastic syndrome: A no-touch approach.

J Card Surg 2022 May 6. Epub 2022 May 6.

Department of Cardio-Thoracic Surgery, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The Netherlands.

Pyoderma gangrenosum (PG) is a rare, chronic inflammatory noninfectious dermatosis. It is associated with underlying systemic or hematological diseases such as myelodysplastic syndrome (MDS) and can be triggered after surgery. Recognition and diagnosis of PG can be difficult as it can mimic a wound infection. Read More

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The Management of Postsurgical Pyoderma Gangrenosum following Breast Surgery.

Plast Reconstr Surg Glob Open 2022 Apr 25;10(4):e4282. Epub 2022 Apr 25.

Division of Plastic Surgery, University of Wisconsin, Madison, Wis.

Background: Postsurgical pyoderma gangrenosum is a rare condition characterized by ulcerative lesion development at surgical sites. It is frequently misdiagnosed as infection and mismanaged with surgical debridement, which only worsens the condition. Achieving the correct diagnosis is crucial to delivering the appropriate medical therapy. Read More

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Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers.

J Dtsch Dermatol Ges 2022 05 29;20(5):619-627. Epub 2022 Apr 29.

University Hospital Erlangen, Dermatological Department, Ulmenweg 18, Erlangen, 91054, Germany.

Background And Objectives: Pyoderma gangrenosum is an ulcerative autoinflammatory disease, lacking distinct histopathological characteristics to differentiate from other ulcerating conditions, like venous leg ulcers. The objective of this study was therefore to find histopathological characteristics of pyoderma gangrenosum in a head-to-head comparison to venous leg ulcers.

Patients And Methods: Eight tissue samples of pyoderma gangrenosum, twelve samples of venous leg ulcers and six samples of healthy skin were stained using an immunohistological multi antigen staining technology. Read More

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Web Exclusive. Annals Story Slam - Papa Is on a Ventilator.

Ann Intern Med 2022 06 29;175(6):SS1. Epub 2022 Apr 29.

Universidad Nacional Mayor de San Marcos, Lima, Peru (A.A.).

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[Development of spindle cell squamous cell carcinoma within a longstanding pyoderma gangrenosum].

Hautarzt 2022 Apr 26. Epub 2022 Apr 26.

Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

Pyoderma gangrenosum (PG) is classified as a neutrophilic dermatosis and presents clinically as painful ulcerations with undermined livid erythema at the margin. Treatment with immunosuppressive drugs is often protracted. The development of malignant tumors in pyoderma gangrenosum has not been reported in the literature. Read More

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First presentation of pyoderma gangrenosum in a patient with partial immunoglobulin A deficiency.

JRSM Open 2022 Apr 13;13(4):20542704221086386. Epub 2022 Apr 13.

Colchester General Hospital, Turner Rd, Mile End, Colchester, CO4 5JL.

We describe the case of a 58-year-old female with an intensely painful and rapidly enlarging necrotic cutaneous ulcer to the right shin on a background of partial immunoglobulin A deficiency (IgAD). She was seen by various healthcare professionals and managed with upscaling antibiotics for cellulitis requiring an inpatient hospital stay. The dermatology team made a clinical diagnosis of ulcerative Pyoderma Gangrenosum (PG) on assessing the patient 13 days post-onset of symptoms. Read More

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Pyoderma gangrenosum: A review of patient's demographics, disease and treatment in 118 patients.

Australas J Dermatol 2022 05 19;63(2):267-269. Epub 2022 Apr 19.

Department of Dermatology, St Vincent's Hospital Melbourne, University of Melbourne, Melbourne, Victoria, Australia.

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