3,210 results match your criteria Pyoderma Gangrenosum


Clinical factors influencing the response to intravenous immunoglobulin treatment in cases of treatment-resistant pyoderma gangrenosum.

J Dermatolog Treat 2019 Apr 18:1-13. Epub 2019 Apr 18.

a Department of Dermatology , Oregon Health & Science University, Center for Health & Healing , 3303 SW Bond Ave. Portland , Oregon 97239 , USA.

Background: Pyoderma gangrenosum (PG) is a neutrophilic disorder which classically presents as chronic, painful ulcers on the lower extremities. There is evidence supporting a potential role for intravenous immunoglobulin (IVIG) as adjuvant therapy for treatment-resistant cases; however, it is unclear which patients will most benefit from this modality of treatment - an especially important consideration given the cost per infusion ($5,000-$10,000). Thus, we sought to identify the clinical characteristics of patients with refractory PG lesions who demonstrated complete healing when IVIG was incorporated into the therapeutic plan. Read More

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http://dx.doi.org/10.1080/09546634.2019.1606888DOI Listing

Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Granuloma annulare (GA) is a fairly common inflammatory skin condition with a range of clinical subtypes. We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. Read More

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March 2019
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PAPASH, PsAPASH and PASS autoinflammatory syndromes: Phenotypic heterogeneity, common biological signature and response to immunosuppressive regimens.

Br J Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, APHP Hôpital St-Louis, Paris.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of skin appendages, commonly associating with other conditions including spondyloarthritis, and is a major component of severe cutaneo-articular autoinflammatory syndromes (AIS), called PAPASH (Pyogenic Arthritis, pyoderma gangrenosum/PG, Acne, HS), PsAPASH (Psoriatic Arthritis, PG, Acne, HS) and PASS (Ankylosing Spondylitis, Acne, PG and HS). The clinical phenotypes of these AIS are ill-defined and unlike PASH or PAPA syndromes, still lack any biological or genetic marker. Moreover, their optimal therapeutic management remains unclear. Read More

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http://dx.doi.org/10.1111/bjd.18003DOI Listing
April 2019
1 Read

Pyoderma gangrenosum succesfully treated with golimumab: Case report and review of the literature.

Dermatol Ther 2019 Apr 12:e12928. Epub 2019 Apr 12.

MD, Dermatological Clinic Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy.

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis frequently related to chronic inflammatory bowel disease often associated with exacerbation of intestinal disease and/or loss of treatment efficacy. However, in patients with comorbidities, such as diabetes, the diagnosis may be a challenge. Here we report the case of DA, a 68-year-old man with a history of ulcerative recto-colitis (URC), type II diabetes and arterial hypertension, who had been treated with Infliximab and Adalimumab in the past. Read More

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http://dx.doi.org/10.1111/dth.12928DOI Listing
April 2019
1 Read

Perineal pyoderma gangrenosum in pregnancy: A case report.

Case Rep Womens Health 2019 Apr 7;22:e00102. Epub 2019 Mar 7.

Department of Obstetrics and Gynecology, Hamanomachi Hospital, Nagahama 3-1-1, Fukuoka, Japan 810-8539, Japan.

Pyoderma gangrenosum is a rare ulcerating neutrophilic dermatosis. We describe the case of a 28-year-old woman with pyoderma gangrenosum in the perineal region during pregnancy. Cytological analysis of a skin biopsy specimen showed neutrophilic infiltrates across all the layers of the dermis, confirming the diagnosis of pyoderma gangrenosum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22149112193000
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http://dx.doi.org/10.1016/j.crwh.2019.e00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441742PMC
April 2019
10 Reads

Paradoxical Skin Reactions to Biologics in Patients With Rheumatologic Disorders.

Front Pharmacol 2019 26;10:282. Epub 2019 Mar 26.

UOC Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Targeted immune-modulating treatment with biological agents has revolutionized the management of immune-mediated inflammatory diseases, including rheumatologic conditions. The efficacy and tolerability of biological agents, from the initial tumour necrosis factor (TNF)-α inhibitors to the new anti-cytokine monoclonal antibodies, have dramatically changed the natural history of debilitating conditions such as rheumatoid arthritis and seronegative spondyloarthropathies. The widening use of biologics across several rheumatologic diseases has been associated with a new class of adverse events, the so-called paradoxical reactions. Read More

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http://dx.doi.org/10.3389/fphar.2019.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443901PMC
March 2019
2 Reads

A boy in his teens with large ulcerations of the head and neck.

Tidsskr Nor Laegeforen 2019 Apr 8;139(7). Epub 2019 Apr 8.

Background: Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, has a predilection for the upper airways, lungs and kidneys. However, any other organ can be affected. Although cutaneous lesions are common, they have only rarely been reported as a primary manifestation of the disease. Read More

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https://tidsskriftet.no/2019/04/noe-laere-av/gutt-i-tenarene
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http://dx.doi.org/10.4045/tidsskr.18.0647DOI Listing
April 2019
2 Reads

Skin and Systemic Inflammation in Schnitzler's Syndrome Are Associated With Neutrophil Extracellular Trap Formation.

Front Immunol 2019 22;10:546. Epub 2019 Mar 22.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial peptides released by neutrophils. NETs were initially described in the context of pathogen defense but are also involved in autoimmune-mediated skin diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438918PMC
March 2019
1 Read

Pyoderma Gangrenosum of the Vulva Treated with Mycophenolate Mofetil and Infliximab.

Dermatol Ther 2019 Apr 9:e12905. Epub 2019 Apr 9.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1111/dth.12905DOI Listing

Absence of donor-site pathergy following fractional autologous full-thickness skin grafting in pyoderma gangrenosum.

Br J Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology& Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.

Pyoderma gangrenosum (PG) is an uncommon inflammatory skin disorder, often associated with arthritis, inflammatory bowel disease, and/or hematologic malignancies [1]. A classic feature of PG is the development or worsening of lesions at areas that experience trauma, also known as pathergy. Autologous skin grafting may be challenging in these patients due to the potential for pathergy at the donor site. Read More

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http://dx.doi.org/10.1111/bjd.17987DOI Listing
April 2019
3 Reads

Breast pyoderma gangrenosum: A rare postoperative complication of antiphospholipid antibody syndrome.

Breast J 2019 Apr 3. Epub 2019 Apr 3.

Surgery Oncological Department, CHU Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.

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http://dx.doi.org/10.1111/tbj.13253DOI Listing
April 2019
1 Read

Adalimumab plus topical tacrolimus for the treatment of pyoderma gangrenosum: Report of a case.

Int Wound J 2019 Apr 1. Epub 2019 Apr 1.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1111/iwj.13123DOI Listing
April 2019
1 Read

State of care for patients with systemic autoinflammatory diseases - Results of a tertiary care survey.

World Allergy Organ J 2019 14;12(3):100019. Epub 2019 Mar 14.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: Systemic autoinflammatory diseases (SAIDs) are rare debilitating disorders of which there is limited awareness and a significant delay in diagnosis. There is no uniform approach in the diagnosis and treatment of these disorders and the real life state of SAID patient care is poorly characterized. The aim of this study was to obtain data on the epidemiology, state of care and the perception of physicians who are involved in the care of SAID patients. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439415PMC
March 2019
6 Reads

Dermatitis artefacta: self-inflicted genital injury.

Int Med Case Rep J 2019 18;12:71-73. Epub 2019 Mar 18.

Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991, Moscow, Russia,

Background: The term dermatitis artefacta (factitious dermatitis, pathomimia) is reserved for the most severe variant of factitious physical disorder and is characterized by exaggerated lying (pseudologia fantastica), sociopathy, geographic wandering (peregrinating) from hospital to hospital, and seeking to be in the patient role.

Objective: This report aims to give attention to the importance of accurate and detailed history, and conducting an appropriate physical examination in patients with life-threatening diseases when the underlying cause is not apparent. The diagnosis of dermatitis artefacta must always be upheld. Read More

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http://dx.doi.org/10.2147/IMCRJ.S192522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429999PMC
March 2019
4 Reads

A case of bullous pyoderma gangrenosum.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of Pathology, CSMMU (ERSTWHILE KGMC), Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1136/bcr-2018-228772DOI Listing
March 2019
1 Read

Tolerability and safety of long-term rituximab treatment in systemic inflammatory and autoimmune diseases.

Rheumatol Int 2019 Mar 28. Epub 2019 Mar 28.

Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway.

Rituximab, an anti-CD20 monoclonal antibody causing selective B-cell depletion, is used for various systemic inflammatory and autoimmune diseases (SIADs). Long-term safety data on rituximab are limited. The objectives of this study were to evaluate the long-term safety and tolerability of rituximab treatment for SIADs. Read More

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http://dx.doi.org/10.1007/s00296-019-04272-1DOI Listing
March 2019
1 Read

Extracutaneous involvement of pyoderma gangrenosum.

Arch Dermatol Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology and OHSU Wound and Hyperbaric Medicine, Oregon Health and Science University, 3303 SW Bond Ave Center for Health and Healing Building 1, Suite 16, Portland, OR, 97239, USA.

Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis (ND) associated with underlying chronic inflammation and/or malignancy. Diagnosis remains to be challenging as a gold standard diagnostic test is lacking. Initial manifestations may include papules, vesicles, or pustules that subsequently develop into ulceration with features of undermining and violaceous borders. Read More

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http://dx.doi.org/10.1007/s00403-019-01912-1DOI Listing
March 2019
1 Read

Multiple eruptive ulcers in a patient with quiescent ulcerative colitis.

BMJ 2019 Mar 28;364:l847. Epub 2019 Mar 28.

St Helier Hospital, Carshalton, UK.

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http://dx.doi.org/10.1136/bmj.l847DOI Listing
March 2019
1 Read

Pyoderma gangrenosum misdiagnosed as necrotising fasciitis or a real association between the two?

J Eur Acad Dermatol Venereol 2019 Mar 21. Epub 2019 Mar 21.

Department of Dermatology, Hôpital Saint André, University Hospital Bordeaux, Bordeaux, France.

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http://dx.doi.org/10.1111/jdv.15585DOI Listing
March 2019
2 Reads

Is Prophylactic Immunosuppressive Therapy for Patients with a History of Postsurgical Pyoderma Gangrenosum Necessary?

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):234-236

Division of Plastic Surgery, Department of Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Postsurgical pyoderma gangrenosum (PSPG) is a rare but serious surgical complication with a predilection for the breast and abdomen. Immunosuppression is the mainstay of treatment of PSPG. In addition, it has become a common practice for clinicians to prophylactically treat patients with a history of PSPG with corticosteroids or immunomodulators during subsequent operative procedures to prevent recurrence. Read More

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http://dx.doi.org/10.4103/JCAS.JCAS_98_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371722PMC
March 2019
2 Reads

Successful Treatment of Pyoderma Gangrenosum With Skin Grafting in a Patient With Acute Lymphoblastic Leukemia.

Dermatol Surg 2019 Mar 12. Epub 2019 Mar 12.

Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Institute of Hematology, Zhejiang University, Hangzhou, China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China.

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http://dx.doi.org/10.1097/DSS.0000000000001882DOI Listing
March 2019
1 Read

[Pyoderma gangrenosum].

Rev Prat 2018 May;68(5):528

Service de dermatologie, hôpital militaire de Tunis, Tunis, Tunisie.

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Pyoderma gangrenosum in a patient with lipoid proteinosis (Urbach-Wiethe disease).

J Eur Acad Dermatol Venereol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Straße 29, Munich, 80802, Germany.

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http://dx.doi.org/10.1111/jdv.15564DOI Listing

Bilateral lower extremity ulcerations, less is more.

Clin Case Rep 2019 Feb 9;7(2):328-330. Epub 2019 Jan 9.

Division of Hospital Medicine University of Florida Gainesville Florida.

The differential diagnosis of lower extremity ulcers must be broad since debridement can be harmful in certain conditions such as pyoderma gangrenosum. Biologic agents may be helpful in the treatment of pyoderma gangrenosum. Read More

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http://doi.wiley.com/10.1002/ccr3.1926
Publisher Site
http://dx.doi.org/10.1002/ccr3.1926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389471PMC
February 2019
2 Reads

Botulinum neurotoxin A is an effective treatment for irritant dermatitis caused by ostomy leaks in patients with retractile stomas.

Br J Dermatol 2019 Mar 6. Epub 2019 Mar 6.

Department of Dermatology, York Teaching Hospital Foundation Trust, York, YO31 8HE, United Kingdom.

Inflammatory or infectious conditions affecting the skin around a stoma occur in up to 73% of ostomates and can be associated with significant morbidity. Peristomal skin complications include dermatitis resulting from mechanical trauma, ICD, allergic contact dermatitis, infections and pyoderma gangrenosum. Peristomal dermatitis is most often caused by leakage of stool or urine that is irritant to the skin. Read More

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http://dx.doi.org/10.1111/bjd.17856DOI Listing
March 2019
1 Read

Ibrutinib and Pyoderma Gangrenosum in a Patient With B-Cell Chronic Lymphocytic Leukemia.

Am J Dermatopathol 2019 Feb 27. Epub 2019 Feb 27.

Dermatology Unit, Galliera Hospital, Genoa, Italy.

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http://dx.doi.org/10.1097/DAD.0000000000001391DOI Listing
February 2019
1 Read

Current clinical issue of skin lesions in patients with inflammatory bowel disease.

Clin J Gastroenterol 2019 Mar 5. Epub 2019 Mar 5.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Inflammatory bowel disease (IBD) is associated with a number of extraintestinal complications, including skin lesions. Most reports have shown that skin lesions are found in 10-15% of IBD cases, although this depends on the definition of skin lesions. The representative skin lesions in patients with IBD are erythema nodosum, pyoderma gangrenosum, Sweet's syndrome, and so on. Read More

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http://link.springer.com/10.1007/s12328-019-00958-y
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http://dx.doi.org/10.1007/s12328-019-00958-yDOI Listing
March 2019
3 Reads

Type I leucocyte adhesion deficiency in Yemenian family managed with appropriate treatment: A case series.

Dermatol Ther 2019 Mar 5:e12864. Epub 2019 Mar 5.

Department of dermatology, University of Science and Technology Hospital, Sana'a, Yemen.

Primary immunodeficiencies are rare, inherited diseases, characterized by altered function or absence of immune cells. Among them is leukocyte adhesion deficiency Type I (LAD-I), an autosomal recessive disorder characterized by primary immunodeficiency, caused by mutations in the ITGB2 gene which produces inability of leucocytes to migrate toward the area of inflammation and is associated with recurrent life-threatening bacterial and fungal infections. Pyoderma gangrenosum (PG) is an uncommon noninfectious neutrophilic dermatosis, characterized by recurrent, necrotic ulcers. Read More

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http://dx.doi.org/10.1111/dth.12864DOI Listing
March 2019
5 Reads

Scoring pyoderma gangrenosum.

Authors:
S Schreml

Br J Dermatol 2019 Mar;180(3):438-439

Department of Dermatology, University Medical Centre Regensburg, Germany, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1111/bjd.17343DOI Listing

Management of a superinfected pyoderma gangrenosum after pacemaker implant.

HeartRhythm Case Rep 2019 Feb 9;5(2):63-65. Epub 2018 Mar 9.

Université de Strasbourg, Service de Cardiologie, Nouvel Hôpital Civil, Strasbourg, France.

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http://dx.doi.org/10.1016/j.hrcr.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379303PMC
February 2019

Dentine hypersensitivity-like tooth pain associated with the use of high-dose steroid therapy.

J Conserv Dent 2019 Jan-Feb;22(1):102-106

Centre for Family Oral Health, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Bangi, Malaysia.

Although corticosteroid provides many clinical benefits, it may cause a range of side effects. A 47-year-old female patient presented with a complaint of pain from her teeth, triggered upon taking cold, hot, and sweet food and drink. From her medical history, she was previously diagnosed with ulcerative colitis. Read More

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http://dx.doi.org/10.4103/JCD.JCD_113_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385580PMC
March 2019
6 Reads

Scrotal necrosis and no Fournier's in sight: a rare case of juvenile gangrenous vasculitis.

BMJ Case Rep 2019 Feb 21;12(2). Epub 2019 Feb 21.

Department of Urology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK.

Juvenile gangrenous vasculitis of the scrotum is a rare entity, of which to our knowledge we describe the first documented case in the UK. It follows a typical disease course, demonstrated by an 18-year-old male who presented with three necrotic scrotal lesions; proceeded by 3 days of fever, pharyngitis and lethargy. Previous cases have been managed successfully with systemic steroids. Read More

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http://dx.doi.org/10.1136/bcr-2018-226530DOI Listing
February 2019
2 Reads

Ustekinumab in a patient with pyoderma gangrenosum and refractory Crohn's disease.

Med Clin (Barc) 2019 Feb 19. Epub 2019 Feb 19.

Servicio de Aparato Digestivo, Hospital Universitario Miguel Servet, Zaragoza, España.

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http://dx.doi.org/10.1016/j.medcli.2018.12.004DOI Listing
February 2019

Extraintestinal manifestations in inflammatory bowel disease - epidemiology, genetics, and pathogenesis.

Expert Rev Gastroenterol Hepatol 2019 Apr 20;13(4):307-317. Epub 2019 Feb 20.

a Department of Gastroenterology and Hepatology , University Hospital Zurich , Zurich , Switzerland.

Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, primarily of, but not restricted to the gut. Extraintestinal manifestations (EIMs) are frequently observed and involve the joints, eyes, hepatobiliary tract, and skin. Areas covered: In this review, we discuss classical EIM focusing on epidemiology, genetics, and pathogenesis, highlighting recent advances in the understanding of EIM. Read More

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http://dx.doi.org/10.1080/17474124.2019.1574569DOI Listing
April 2019
1 Read

Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Dermatology, Saint Louis University, St Louis, Missouri (Dr Abate);the Departments of Dermatology (Dr Battle),and Pathology (Drs Gardner and Shalin),University of Arkansas for Medical Sciences, Little Rock; and the Department of Dermatology, University of Mississippi Medical Center, Jackson (Dr Emerson).

Context.—: Fatal dermatologic diseases and ones with high morbidity can occur in the inpatient setting. In such cases, prompt and accurate assessment of a bedside skin biopsy is required. Read More

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http://dx.doi.org/10.5858/arpa.2018-0239-RADOI Listing
February 2019
3 Reads

Peristomal pyoderma gangrenosum: an exceedingly rare and overdiagnosed entity?

J Am Acad Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, University of California, Davis Medical Center, Sacramento, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193028
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http://dx.doi.org/10.1016/j.jaad.2019.02.026DOI Listing
February 2019
16 Reads

Colocutaneous fistula through ulcerative colitis and cancer to the pyoderma gangrenosum: a never-ending story for a single patient. Case report.

G Chir 2019 Jan-Feb;40(1):39-43

Background: Inflammatory bowel diseases may be associated with many extraintestinal complications, that in some cases can represent the first onset of these disorders. In particular during the course of the disease, Ulcerative Colitis develops extraintestinal manifestations very frequently. One of the rarest is pyoderma gangrenosum, a noninfectious neuthrophilic dermatosis, that can involve most commonly legs but also other parts of the skin or mucosas. Read More

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February 2019
5 Reads

Intravenous immunoglobulin treatment: Where do dermatologists stand?

Authors:
Selma Emre

Dermatol Ther 2019 Feb 13:e12854. Epub 2019 Feb 13.

Department of Dermatology, Yildirim Beyazit University, Medical School, Ankara, Turkey.

Intravenous immunoglobulins (IVIG) are therapeutic products, comprising polyclonal IgGs, which are obtained from human plasma pool of healthy blood donors. Despite the lack of Food and Drug Administration (FDA) approval, the experience of using IVIG in various dermatological diseases increases day by day and exciting results are reported. However, experience with the use of IVIG in dermatological indications are mostly case reports whereas randomized, controlled, double-blind, multicentric studies have not been performed. Read More

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http://dx.doi.org/10.1111/dth.12854DOI Listing
February 2019
5 Reads

A case of persistent fever, cutaneous manifestations and pulmonary and splenic nodules: clinical experience and a literature review.

Intern Med J 2019 Feb;49(2):247-251

Department of Respiratory, Peking University Shenzhen Hospital, Shenzhen, Gangdong, China.

Pyoderma gangrenosum (PG) is a rare and recurrent ulcerating, non-infectious, inflammatory dermatosis, with occasional concomitant extracutaneous manifestations. The pathogenesis and aetiology of PG are unknown. Moreover, early diagnosis is challenging because there are several visceral manifestations that may occur prior to the skin findings, such that misdiagnosis of PG as an infection is common. Read More

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http://dx.doi.org/10.1111/imj.14201DOI Listing
February 2019
2 Reads

Successful Treatment of Pyoderma Gangrenosum with Concomitant Tofacitinib and Infliximab.

Inflamm Bowel Dis 2019 Feb 8. Epub 2019 Feb 8.

Division of Gastroenterology and Hepatology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1093/ibd/izz015DOI Listing
February 2019

Overall and Subgroup Prevalence of Pyoderma Gangrenosum Among Patients with Hidradenitis Suppurativa: a population based analysis in the United States.

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell. New Hyde Park, NY, USA. Electronic address:

Background: Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are reported to coexist, although prevalence of PG among HS patients has not been systematically evaluated.

Objective: To evaluate PG prevalence among HS patients.

Methods: Cross-sectional analysis of adults with PG among HS and non-HS patients using electronic health records data from a population-based sample of 55 million patients. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.004DOI Listing
February 2019
1 Read

IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation.

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address:

IL-17E (IL-25) is a member of the IL-17 cytokine family involved in the promotion of type 2 immune responses. Recently, IL-17E has been reported to be up-regulated in distinct skin inflammatory diseases such as psoriasis and atopic and contact dermatitis. We assessed the role played by IL-17E in skin inflammation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193010
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http://dx.doi.org/10.1016/j.jid.2019.01.021DOI Listing
February 2019
15 Reads

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
15 Reads

Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.

Pseudocarcinomatous (pseudoepitheliomatous) hyperplasia represents reactive epidermal change mimicking squamous cell carcinoma (SCC), owing to a variety of inflammatory and neoplastic phenomena, including deep fungal infections, CD30-positive lymphomas, and others. We report a case of Sweet syndrome (SS) arising in a patient with acute myelogenous leukemia, with persistent orolabial involvement which mimicked SCC both clinically and microscopically, but resolved entirely with adequate corticosteroid treatment. Clinicians should be aware that neutrophilic dermatoses such as SS and pyoderma gangrenosum may rarely exhibit pseudocarcinomatous epidermal changes similar to those seen in soft tissue infections and other inflammatory dermatoses. Read More

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http://dx.doi.org/10.1111/cup.13436DOI Listing
February 2019
1 Read

Arterial hand ulcer: A common disease in an uncommon location.

JAAD Case Rep 2019 Feb 25;5(2):147-149. Epub 2019 Jan 25.

Oregon Health and Science University, School of Medicine, Portland, Oregon.

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http://dx.doi.org/10.1016/j.jdcr.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355430PMC
February 2019

Pyoderma gangrenosum: a presenting sign of myelodysplastic syndrome in undiagnosed Fanconi anemia.

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.

A 26-year-old man with a history of congenital bilateral microtia, unilateral renal agenesis, left aural atresia, and right external auditory canal occlusion admitted for right rib cartilage graft harvest and left ear re-construction. Following surgery, an ulceration with violaceous borders and a yellow fibrinous base unresponsive to broad-spectrum antibiotics developed at the harvest site. The wound was expanding and not responsive to systemic broad-spectrum antibiotics. Read More

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January 2019
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Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.

PLoS One 2019 25;14(1):e0210436. Epub 2019 Jan 25.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background/aims: Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS), we analysed epidemiological as well as clinical factors being associated with the onset of pyoderma gangrenosum, erythema nodosum and aphthous ulcers in IBD patients.

Methods: We included 3266 SIBDCs patients, 1840 with Crohn's disease (CD) and 1426 with ulcerative colitis (UC) or IBD unclassified (IBDU) and analysed the association of cutaneous manifestations with age, age at diagnosis time, type of disease, gender, family history, HLA-allotype, smoking, intestinal disease activity, therapy and other extraintestinal manifestations (EIM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347222PMC
January 2019
2 Reads

[One case of pyoderma gangrenosum in the lower limbs in Tibetan Plateau treated with vacuum sealing drainage combined with irrigation of oxygen loaded fluid].

Zhonghua Shao Shang Za Zhi 2019 Jan;35(1):69-71

Department of Burns and Plastic Surgery, the General Hospital of PLA Tibet Military Area Command, Lhasa 850000, China.

A 54 years old male patient with chronic leg ulcers was admitted in our hospital in November 2017. He was diagnosed as pyoderma gangrenosum by the pathological examination. Then the wound was treated with simple vacuum sealing drainage combined with irrigation of oxygen loaded fluid. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.01.013DOI Listing
January 2019

A case of erosive pustular dermatosis of the scalp in a pediatric patient.

JAAD Case Rep 2019 Feb 11;5(2):118-120. Epub 2019 Jan 11.

Department of Dermatology, University of Texas Medical Branch, Galveston, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330372PMC
February 2019

Pyoderma gangrenosum as first manifestation of Crohn's disease.

Tech Coloproctol 2019 01 17;23(1):79-80. Epub 2019 Jan 17.

Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1007/s10151-018-1916-9DOI Listing
January 2019
1 Read