6,010 results match your criteria Pyoderma Gangrenosum


Safety and Efficacy of Rituximab in Multiple Sclerosis: A Retrospective Observational Study.

J Immunol Res 2018 12;2018:9084759. Epub 2018 Nov 12.

Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.

Objective: To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting.

Methods: Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected from medical charts. The main efficacy outcomes assessed were annualized relapse rate (ARR) and proportion of patients free from relapses, disability progression, or magnetic resonance imaging (MRI) activity. Read More

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November 2018
2 Reads

Refractory pyoderma gangrenosum in a patient with Crohn´s Disease: complete response to Ustekinumab.

J Crohns Colitis 2018 Dec 7. Epub 2018 Dec 7.

Gastroenterology department, Hospital Garcia de Orta, Almada, Portugal.

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December 2018

Abdominal ultrasound in paraneoplastic Pyoderma gangrenosum caused by renal carcinoma.

Med Ultrason 2018 Dec;20(4):541-542

2nd Medical Clinic, UMF Iuliu Hatieganu University, Cluj-Napoca, Romania.

We present the case of a 60-year-old male patient, with refractory ulcers in the groin. Ultrasoundand CT showed a large vascularized tumor of the kidney with cystic parts and inhomogeneous dynamic behaviour. Histology demonstrated Pyoderma gangrenosum (ulcer) and well differentiated adenocarcinoma (kidney). Read More

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December 2018
3 Reads

Pyoderma gangrenosum around an ileostoma: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13415

Department of Colorectal Surgery, Ningbo No.2 Hospital, No.41 Northwest Street, Ningbo, Zhejiang Province, China.

Rationale: Pyoderma gangrenosum (PG) is a rare postoperative complication of enterostomy, mostly developing from dermatitis, which may have serious consequence.

Patient Concerns: A patient with lower rectal cancer receiving low anterior resection (LAR) and protective ileostomy was initially diagnosed with dermatitis, which very quickly developed to PG, though no medical or familial history was found.

Diagnosis: We diagnosed the patient with peristoaml dermatitis starting from a tiny skin ulceration, but corrected the diagnosis to PG because of the rapid development and severe consequences. Read More

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November 2018
3 Reads

Hepatobiliary and Pancreatic: Pyoderma gangrenosum of the pancreas successfully treated with infliximab.

J Gastroenterol Hepatol 2018 Nov 22. Epub 2018 Nov 22.

Department of Gastroenterology, Academic Hospital Roeselare, Roeselare, Belgium.

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November 2018
1 Read

[PAPA syndrome with Crohn's disease and primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome].

Hautarzt 2018 Nov 22. Epub 2018 Nov 22.

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Rostock, Rostock, Deutschland.

Background: The PAPA syndrome, an acronym for pyogenic sterile arthritis, pyoderma gangraenosum and acne, is an autosomal dominant hereditary disease which is caused by a mutation in the PSTPIP1 ("proline-serine-threonine phosphatase interacting protein 1") gene located on chromosome 15 and encodes the proline-serine-threonine phosphatase-interacting protein 1. An association with Crohn's disease (CD), autoimmune diseases of the liver and PAPA syndrome has not yet been reported in the literature.

Objective: To thoroughly investigate a family with three affected members (mother and 2 children) with newly diagnosed PAPA syndrome and intestinal and hepatobiliary symptoms. Read More

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November 2018
5 Reads

Utility of Skin Biopsy and Culture in the Diagnosis and Classification of Chronic Ulcers: A Single-Institution, Retrospective Study.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Department of Pathology, University of Washington, Seattle, WA.

In the United States, chronic ulcers affect 6.5 million people, with a cost of ≈$20 million annually. The most common etiology of chronic ulcers in the United States is venous stasis, followed by arterial insufficiency and neuropathic ulcers. Read More

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November 2018
6 Reads

Superficial granulomatous pyoderma in a patient with ulcerative colitis successfully treated with cyclosporine A.

Int J Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.

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November 2018
2 Reads

Association of pyoderma gangrenosum, erythema nodosum and aseptic liver abscess without significant underlying disease.

Clin Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan.

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November 2018
1 Read

Diagnostic pitfalls in the differentiation between pyoderma gangrenosum and necrotizing fasciitis.

Acta Orthop Belg 2018 Mar;84(1):17-24

Pyoderma gangrenosum and necrotizing fasciitis are two rare pathologic entities with a similar clinical image, but a who require a very different management. In general physicians, orthopedics, dermatologists, plastic surgeons will hardly ever see it, but when they do it is very important to distinguish between both. In this paper with the focus on the practical approach ,we expose the diagnostic pitfalls in the differential diagnosis, explain how to prevent them and summarize the evidence on therapeutic management. Read More

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March 2018
1 Read

Two cases of maggot debridement therapy in pyoderma gangrenosum.

JAAD Case Rep 2018 Nov 10;4(10):1027-1029. Epub 2018 Nov 10.

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.

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November 2018
1 Read

Wound Healing Disorder Caused by Pyoderma Gangrenosum.

Am Surg 2018 Mar;84(3):e112-e113

Department of Dermatology, Universitaetsklinikum Muenster, Muenster, Germany.

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March 2018
1 Read

Pyoderma Gangrenosum After Facelift and Otoplasty Surgery: Case Presentations and Literature Review.

Authors:
Joe Niamtu

J Oral Maxillofac Surg 2018 Oct 24. Epub 2018 Oct 24.

Private Practice, Cosmetic Facial Surgery, Midlothian, VA. Electronic address:

Purpose: Pyoderma gangrenosum (PG) is an uncommon autoimmune, neutrophilic, ulcerative skin condition of uncertain etiology believed to result from dysregulation of the immune system. Although this entity is well recognized by dermatologists, other specialists are less familiar with diagnosis and treatment. This report describes a severe PG reaction to an elective cosmetic facelift, which is believed to be the second reported case of PG after facelift surgery. Read More

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October 2018
4 Reads

Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study.

Authors:
Eden Lake

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

Pyoderma gangrenosum is a painful ulcerating disease. The current evidence base for treatment is limited. In a large prospective study of topical treatments, 44% of patients were healed by 6 months. Read More

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November 2018
5 Reads

[Pitfalls of Differential Diagnosis in Dermatologic Surgery].

Dtsch Med Wochenschr 2018 Nov 15;143(23):1682-1689. Epub 2018 Nov 15.

Evaluation of skin diseases can be challenging for non-dermatologists. Even obvious well-characterized skin pathologies might be misleading and thus treatment can fail. Particularly the differentiation of surgical treated entities is important, for example the management of a wound healing disturbance profoundly differs from that of a pyoderma gangrenosum. Read More

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November 2018
1 Read

Pyoderma Gangrenosum Following Carpal Tunnel Release: A Case Report.

JBJS Case Connect 2018 Nov 14. Epub 2018 Nov 14.

Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Case: A 51-year-old woman with diabetes developed wound complications consistent with presumed infection 5 days after undergoing a carpal tunnel release. Despite multiple debridements, the wounds continued to necrose and deteriorate. A diagnosis of pyoderma gangrenosum eventually was made, and the condition improved with the administration of systemic corticosteroids. Read More

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November 2018
1 Read

Pyoderma Gangrenosum and Extensive Aseptic Chest Wall Abscess in a Patient with Inflammatory Bowel Disease.

Isr Med Assoc J 2018 Nov;20(11):712-713

Department of Medicine A, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.

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November 2018
3 Reads

Successful treatment of pyoderma gangrenosum with concomitant immunoglobulin A nephropathy: A case report and review of literature.

World J Clin Cases 2018 Nov;6(13):703-706

Cerebrovascular Disease Center, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.

Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune diseases. However, PG rarely shows visceral involvement, especially in the kidney. A 20-year-old female presented with pedal edema and skin ulceration of both lower limbs. Read More

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November 2018
1 Read

Blastomycosis-like pyoderma: a diagnostic as well as therapeutic challenge.

G Ital Dermatol Venereol 2018 Nov 9. Epub 2018 Nov 9.

Department of Dermatology, R. D. Gardi Medical College, Ujjain, India -

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November 2018
2 Reads

A rare skin condition masquerading as a serious wound infection.

J Surg Case Rep 2018 Nov 5;2018(11):rjy299. Epub 2018 Nov 5.

Medical Oncology, St John of God Subiaco Hospital, Subiaco, Western Australia.

Pyoderma gangrenosum is a rare, serious and commonly missed condition that can effect post-operative surgical patients. The condition is commonly misdiagnosed as a wound infection, with subsequent inappropriate antibiotic therapy and wound debridement. We present the case of a 46-year-old patient who suffered this delayed diagnosis and multiple unnecessary interventions. Read More

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November 2018
2 Reads

A case of rituximab-induced pyoderma gangrenosum.

JAAD Case Rep 2018 Nov 29;4(10):979-981. Epub 2018 Oct 29.

Schulich School of Medicine and Dentistry, London, Canada.

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November 2018
1 Read

Tofacitinib for the Treatment of Pyoderma Gangrenosum.

Clin Gastroenterol Hepatol 2018 Nov 4. Epub 2018 Nov 4.

Multidisciplinary Center for Inflammatory Bowel Disease, University of North Carolina, Chapel Hill, NC; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC. Electronic address:

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November 2018
11 Reads

Keratin Gel as an Adjuvant in the Treatment of Recalcitrant Pyoderma Gangrenosum Ulcers: A Case Report.

Acta Derm Venereol 2018 Nov 5. Epub 2018 Nov 5.

Department of Dermatology and Allergy Centre, Odense University Hopsital, DK-5000 Odense, Denmark.

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November 2018
4 Reads

Clinical Features of Neutrophilic Dermatosis Variants Resembling Necrotizing Fasciitis.

JAMA Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, University of California San Francisco, San Francisco.

Importance: Pyoderma gangrenosum and necrotizing Sweet syndrome are diagnostically challenging variants of neutrophilic dermatosis that can clinically mimic the cutaneous and systemic features of necrotizing fasciitis. Improved characterization of these rare variants is needed, as improper diagnosis may lead to inappropriate or delayed treatment and the potential for morbidity.

Objective: To determine the characteristics of necrotizing neutrophilic dermatosis to improve diagnostic accuracy and distinguish from infection. Read More

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October 2018
4 Reads

Efficacy of Systemic Dapsone Treatment for Pyoderma Gangrenosum: A Retrospective Review.

J Drugs Dermatol 2018 Oct;17(10):1058-1060

Introduction: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis commonly treated with steroid immunosuppression. The utility of dapsone as a non-immunosuppressive treatment for PG has been reported in case reports and series. We sought to evaluate the response and tolerability of concurrent systemic dapsone therapy for treating PG. Read More

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October 2018
8 Reads

Pyoderma gangrenosum and its impact on quality of life: a multicentre, prospective study.

Br J Dermatol 2018 Oct 26. Epub 2018 Oct 26.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

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October 2018
2 Reads

Pyoderma Gangrenosum Misdiagnosis Resulting in Amputation: A Review.

J Trauma Acute Care Surg 2018 Oct 23. Epub 2018 Oct 23.

Department of Dermatology, Oregon Health & Science University, Portland, OR, USA.

Pyoderma Gangrenosum (PG) is a rare, ulcerative cutaneous disorder typically affecting the lower extremities. The clinical appearance of PG can mimic various cutaneous infections and neoplasms, leading to misdiagnosis and mistreatment including unnecessary surgical interventions such as debridements and even amputations. Diagnostic criteria exist, including characteristic clinical appearance and the exclusion of other diagnoses, however no definitive test exists to confirm the diagnosis of PG. Read More

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October 2018
10 Reads

Pyoderma gangrenosum associated with dulaglutide therapy.

Int J Dermatol 2018 Oct 21. Epub 2018 Oct 21.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

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October 2018

[Ecthyma gangrenosum].

Pan Afr Med J 2018 5;30:95. Epub 2018 Jun 5.

University Mohammed V, Ibn Sina, Hospital University, Rabat, Morocco.

Ecthyma gangrenosum (EG) is a severe potentially lethal cutaneous infection that progresses sequentially from maculopapular rash to haemorrhagic bulla and then to necrotic ulceration with surrounding erythema. It usually occurs in immunocompromised patients (aplasia secondary to chemotherapy, HIV infection, neutropenia or functional deficit of neutrophils, agammaglobulinemia). It rarely affects healthy people. Read More

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October 2018
7 Reads

Tumor necrosis factor-alpha inhibitors for the treatment of pyoderma gangrenosum not associated with inflammatory bowel diseases: a multicenter retrospective study.

J Am Acad Dermatol 2018 Oct 17. Epub 2018 Oct 17.

Service de dermatologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP), Université Paris Diderot, F-75010 Paris. Electronic address:

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October 2018
5 Reads

Efficacy and safety of etanercept for postoperative pyoderma gangrenosum after infliximab serum sickness.

Dermatol Ther 2018 Oct 20:e12774. Epub 2018 Oct 20.

Assistance Publique- Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, Paris, France.

Non-peristomal postoperative pyoderma gangrenosum (PPG) is a rare subtype of pyoderma gangrenosum that occurs in the early postoperative period at surgical incisions, most commonly after breast surgery. Early diagnosis and treatment is essential to prevent severe scaring. TNF-alpha inhibitor infliximab was reported to be efficient in treatment of PPG refractory to systemic corticosteroids. Read More

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October 2018
3 Reads

[Brief review of the diagnostics of pyoderma gangraenosum].

Z Rheumatol 2018 Dec;77(10):857-859

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland.

The diagnosis of pyoderma gangraenosum was previously made as a diagnosis of exclusion. For this reason repeated attempts have been made in recent years to develop new diagnostic scores, whereby the typical clinical and anamnestic aspects were usually taken into account and the relevant differential diagnoses were excluded. With the PARACELSUS score an evaluated diagnostic score was presented for the first time. Read More

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December 2018

Evaluating the Efficacy of Topical Dapsone Treatment for Pyoderma Gangrenosum: A Retrospective Case Series.

J Cutan Med Surg 2018 Nov/Dec;22(6):650-651

1 Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

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October 2018
1 Read

Penile pyoderma gangrenousm treated with cyclosporine: Case report.

J Pak Med Assoc 2018 Jul;68(7):1148-1150

Department of Dermatology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Pyoderma gangrenosum (PG) of the penis is a very rare entity in medicine and it can be destructive. Generally, pyoderma gangrenosum is known to be common among patients with systemic diseases such as inflammatory bowel diseases, polyarthritis, diverticulosis, paraproteinaemia, myeloma, leukaemia, active chronic hepatitis, and Behcet syndrome. Early diagnosis and administrating effective treatment can prevent permanent damage to the penis and save the patient's social life. Read More

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July 2018
4 Reads

Vulvovaginal pyoderma gangrenosum in association with rituximab.

JAAD Case Rep 2018 Oct 4;4(9):907-909. Epub 2018 Oct 4.

Department of Dermatology, Rush University Medical Center, Chicago, Illinois.

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October 2018
2 Reads

Bullous pyoderma gangrenosum secondary to underlying multiple myeloma: treated with ciclosporin.

Clin Exp Dermatol 2018 Oct 7. Epub 2018 Oct 7.

Department ofDermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.

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October 2018
7 Reads
1.230 Impact Factor

Toll-like receptor signaling induces the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes.

J Dermatol Sci 2018 Nov 15;92(2):181-187. Epub 2018 Sep 15.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama, Japan.

Background: Lympho-epithelial Kazal-type inhibitor (LEKTI) tightly controls the activities of serine proteases such as kallikrein-related peptidase (KLK) 5 and KLK7 in the epidermis. LEKTI is known to be an essential molecule for the epidermal skin barrier, as demonstrated by SPINK5 nonsense mutation, which results in Netherton syndrome. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns or damage-associated molecular patterns and produce inflammatory cytokines, chemokines, and antimicrobial peptides. Read More

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November 2018
2 Reads

[Recurrent pyoderma in Kindler syndrome].

Hautarzt 2018 Oct;69(Suppl 1):16-18

Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.

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October 2018
2 Reads

Characterization of a leukocidin identified in Staphylococcus pseudintermedius.

PLoS One 2018 27;13(9):e0204450. Epub 2018 Sep 27.

Department of Biomedical and Diagnostic Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, United States of America.

Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F (fast) components. They impair the innate immune system, the first line of defense against these pathogens. Read More

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September 2018
2 Reads

Pyoderma Gangrenosum-like Wounds in Leukocyte Adhesion Deficiency: Case Report and Review of Literature.

Plast Reconstr Surg Glob Open 2018 Aug 8;6(8):e1886. Epub 2018 Aug 8.

Department of Surgery, Division of Plastic Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah.

Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency characterized by impairment of leukocyte migration during an inflammatory response. LAD patients can experience recurrent neutrophilic wounds similar to pyoderma gangrenosum (PG), predominantly of the skin and mucosal surfaces. There have been only a few reports addressing the management of extensive, life-threatening wounds in LAD patients. Read More

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August 2018
1 Read

Efficacy of topical calcineurin inhibitors in pyoderma gangrenosum.

Dermatol Ther 2018 09 25;31(5):e12697. Epub 2018 Sep 25.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

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September 2018
2 Reads

Superficial granulomatous pyoderma of the leg improved after conservative management with Unna boot and intralesional steroid injections.

JAAD Case Rep 2018 Sep 14;4(8):797-799. Epub 2018 Sep 14.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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September 2018
1 Read

Is probiotic use beneficial for skin lesions in patients with inflammatory bowel disease?

J Dermatolog Treat 2018 Nov 19:1-5. Epub 2018 Nov 19.

a Dermatology Unit, Department of Medical, Surgical and Experimental Sciences , University of Sassari , Sassari , Italy.

Background: Inflammatory bowel diseases (IBDs) are associated with extraintestinal manifestations including skin lesions. The intestinal microflora plays a key role in the development and course of IBD.

Aim: To examine the efficacy of probiotics and the occurrence of skin lesions in patients with IBD. Read More

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November 2018
1 Read

Acute febrile neutrophilic dermatosis in a patient with Crohn's disease: case report and review of the literature.

Acta Dermatovenerol Alp Pannonica Adriat 2018 09;27(3):161-163

Department of Gastroenterology, University Medical Centre Maribor, Maribor, Slovenia.

Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. Read More

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September 2018
11 Reads

Metastatic vulvovaginal Crohn disease in the setting of well-controlled intestinal disease.

Cutis 2018 Aug;102(2):E16-E18

Dell Medical School, University of Texas Southwestern, Austin, USA.

The cutaneous manifestations of Crohn disease (CD) are varied and include pyoderma gangrenosum, erythema nodosum, and metastatic CD (MCD). The latter is defined as the occurrence of granulomatous lesions at a skin site distant from the gastrointestinal tract. Metastatic CD involving the vulva and perineum is rare and thus often is difficult to diagnose. Read More

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August 2018
2 Reads

Epidemiology of pyoderma gangrenosum in Japanese patients by questionnaire survey.

J Dermatol 2018 Sep 19. Epub 2018 Sep 19.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

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September 2018
9 Reads

Late-onset post-mammoplasty pyoderma gangrenosum treated with tobacco-pouch suture combined with oral corticosteroids.

G Ital Dermatol Venereol 2018 Sep 18. Epub 2018 Sep 18.

Dermatology Unit, Department of Physiopathology and Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

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September 2018
1 Read

Imaging findings of sterile pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome: differential diagnosis and review of the literature.

Pediatr Radiol 2018 Sep 17. Epub 2018 Sep 17.

Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.

Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autosomal-dominant autoinflammatory disease of incomplete penetrance and variable expression. PAPA syndrome is the result of a mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene located on chromosome 15, which results in an abnormal overproduction of the pro-inflammatory cytokine interleukin-1β (IL-1). This syndrome clinically manifests as early onset of recurrent episodes of acute aseptic inflammation of the joints, generally occurring in the first two decades of life, followed by manifestation of characteristic skin lesions in the third decade, after an obvious decline in the joint symptoms. Read More

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September 2018
1 Read