3,051 results match your criteria Pyoderma Gangrenosum
Dermatol Surg 2018 Jun 21. Epub 2018 Jun 21.
Department of Vascular Surgery, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom Department of Dermatology, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom Department of Vascular Surgery, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
BMJ Case Rep 2018 Jun 19;2018. Epub 2018 Jun 19.
Department of Rheumatology, Peterborough City Hospital, Peterborough, United Kingdom.
Pyoderma gangrenosum (PG) coexisting with Cogan's syndrome (CS) is uncommon, although cutaneous manifestations are known to develop in CS. A middle-aged white female patient had chronic relapsing PG requiring ciclosporin and prednisolone. Despite receiving optimal doses of ciclosporin and prednisolone, she developed acute vestibulo-auditory symptoms as a result of CS. Read More
Int J Dermatol 2018 Jun 19. Epub 2018 Jun 19.
Department of Dermatology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Eplasty 2018 18;18:ic11. Epub 2018 May 18.
Department of Dermatology, University of Pisa, Pisa, Italy.
J Audiol Otol 2018 Jun 14. Epub 2018 Jun 14.
Department of Otorhinolaryngology-Head and Neck Surgery, Wonju Severance Christian Hospital, Yonsei University College of Medicine, Wonju, Korea.
Pyoderma gangrenosum (PG) is primarily, a sterile, inflammatory, neutrophilic dermatosis, characterized by recurrent cutaneous ulceration with mucopurulent or hemorrhagic exudate. The incidence of PG is uncertain, but it is estimated to be about 3-10 patients per million per year. It occurs most commonly on the lower legs, but has been reported at other sites of the body as well. Read More
Dermatol Reports 2018 Apr 14;10(1):7445. Epub 2018 May 14.
Department of Pathology, Trakya University Faculty of Medicine, Edirne, Turkey.
The differential diagnosis of chronic ulcers covers a wide range of diseases and poses a diagnostic challenge. Subcutaneous ischemic arteriolosclerosis can lead to local ischaemia and ulceration as a result of arteriolar narrowing and reduction of tissue perfusion. This pathophysiological feature can be seen in eutrophication (nonuremic calciphylaxis) in morbid obesity, hypertensive ischemic leg ulcer (Martorell ulcer) and calciphylaxis in chronic renal insufficiency. Read More
Int Wound J 2018 Jun 6. Epub 2018 Jun 6.
Department of Dermatology, ASST degli Spedali Civili, Spedali Civili di Brescia, Brescia, Italy.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterised by painful, necrotic ulcerations. PG is described as a rare disease: the world-wide incidence is estimated to be around 3 to 10 cases per million population per year. These estimations are based mostly on case reports and retrospective case series; there are no prospective, multicentre studies on the matter. Read More
Case Rep Infect Dis 2018 26;2018:8907542. Epub 2018 Apr 26.
Department of Infectious Diseases, McMaster University, Hamilton, ON, Canada.
In this article, we present a case of pyoderma gangrenosum (PG), misdiagnosed initially as a necrotizing infection that significantly worsened due to repeated surgical debridement and aggressive wound care therapy, almost resulting in limb amputation despite antibiotic therapy. The PG lesions improved after pancytopenia were further investigated, and the diagnosis and treatment of an underlying hematologic malignancy was initiated. The diagnosis and management of PG is challenging given the paucity of robust clinical evidence, lack of standard diagnostic criteria, and absence of clinical practice guidelines. Read More
Ann Dermatol 2018 Jun 23;30(3):392-393. Epub 2018 Apr 23.
Department of Dermatology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Clin Exp Dermatol 2018 May 30. Epub 2018 May 30.
Department of Dermatology, La Paz Hospital, Madrid, Spain.
Wounds 2018 May;30(5):E52-E56
Introduction: Pyoderma gangrenosum (PG) is a rare, inflammatory, noninfectious skin disorder that is idiopathic in nature; however, it may occur as a rare complication of breast surgery. The mainstay of treatment is medical immunosuppression.
Case Report: This report describes the case of a 46-year-old woman who developed PG of both breasts following bilateral reduction mammoplasty and mastopexy. Read More
J Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
Department of Dermatology, York Hospital, York, YO31 8HE.
BACKGROUND AND AIMS Vulval Crohn disease (VCD) is a rare extra-intestinal cutaneous manifestation of Crohn disease (CD). VCD is often unrecognised and misdiagnosed and can be difficult to treat. The aim of the study was to describe the clinical presentation, associated features and response to treatment modalities in patients with VCD. Read More
Int J Dermatol 2018 May 27. Epub 2018 May 27.
Department of Dermatology, UC Davis School of Medicine, Sacramento, CA, USA.
Inflamm Bowel Dis 2018 May 17. Epub 2018 May 17.
Department of Dermatology, Cleveland Clinic, Cleveland, Ohio.
Pyoderma gangrenosum (PG) is a rare ulcerative skin disease of unknown etiology often associated with systemic inflammatory conditions, most commonly inflammatory bowel disease (IBD). The most common presentation of PG is spontaneous rapid formation of an extremely painful ulcer on the extremities, associated with significant morbidity and mortality. Rarely, PG can also occur as a chronic peristomal complication or as an acute postoperative complication of a surgical wound. Read More
J Dtsch Dermatol Ges 2018 Jun 22;16(6):763-768. Epub 2018 May 22.
Department of Dermatology, University Clinic of Navarra, University of Navarra, IdiSNA, Navarra Institute for Health Research, Navarra, Spain.
J Dermatol 2018 May 21. Epub 2018 May 21.
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leukocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leukocytes. Reports on the clinical efficacy of GMA in patients with skin lesions have appeared in the published work. Dermatological diseases, which are known to respond to GMA, include pyoderma gangrenosum, skin lesions of Behçet's disease, rheumatoid arthritis, pustular psoriasis, psoriatic arthritis, adult-onset Still's disease, Sweet's syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus rashes. Read More
J Eur Acad Dermatol Venereol 2018 May 15. Epub 2018 May 15.
Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
Background: The prevalence of hidradenitis suppurativa (HS) in Asia is unknown. The associations between HS and other autoimmune disorders have rarely been reported.
Objective: We sought to determine the prevalence of and diseases associated with HS using the National Health Insurance (NHI) database. Read More
Postepy Dermatol Alergol 2018 Apr 24;35(2):212-216. Epub 2018 Apr 24.
Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Nicolaus Copernicus University in Torun, Faculty of Medicine in Bydgoszcz, Poland.
Clin Exp Dermatol 2018 May 13. Epub 2018 May 13.
Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Auris Nasus Larynx 2018 Oct 10;45(5):1130-1134. Epub 2018 May 10.
Department of Otolaryngology, Japanese Red Cross Saitama Hospital, Shintoshin 1-5, Chuo-ku, Saitama-shi, Saitama, 330-8533, Japan.
Pyoderma gangrenosum is a rare ulcerative condition associated with various systemic diseases. Lesions on the lower extremities and the trunk are common, but lesions on the nose are rare. Here we report a case of pyoderma gangrenosum on the nose. Read More
J Am Acad Dermatol 2018 May 9. Epub 2018 May 9.
Ohio State University Division of Gastroenterology, OSU Wexner Medical Center, Columbus, OH.
J Dtsch Dermatol Ges 2018 May;16(5):617-620
Department of Dermatology, Venerology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
J Plast Reconstr Aesthet Surg 2018 Jul 28;71(7):1023-1032. Epub 2018 Mar 28.
Department of Plastic, Reconstructive, Hand and Burn Surgery, Bogenhausen Academic Hospital, Engelschalkingerstr. 77, 81925, Munich, Germany.
Background: Post-surgical pyoderma gangrenosum (PSPG) is a rare inflammatory skin disorder of unknown aetiology. Given its similar presentation to wound infection and lack of reliable diagnostic tests as well as pathognomonic clinical features, PSPG is difficult to diagnose. The aim of this review was to identify factors contributing to PSPG to aid with timely diagnosis and appropriate therapy. Read More
Ann Dermatol Venereol 2018 Jun - Jul;145(6-7):445-450. Epub 2018 May 7.
Service de médecine interne, hôpital Militaire Moulay Ismail, Méknes, Maroc.
Background: Pyoderma gangrenosum (PG) is a rare form of neutrophilic dermatosis and is a potential complication in a number of systemic diseases. These include blood diseases, which represent 3.5% of cases, with the main forms being monoclonal gammopathy and acute myeloid leukemia. Read More
Clin Exp Rheumatol 2018 Jan-Feb;36 Suppl 110(1):32-38. Epub 2018 May 3.
UOC Pediatria 2, G. Gaslini Institute, Genova, Italy.
Autoinflammatory diseases (AIDs) encompass a heterogeneous group of disorders pathogenetically related to an abnormal activation of the innate immunity and clinically characterised by aseptic inflammation in the affected organs in the absence of high titer of circulating autoantibodies or autoreactive T cells. In classic monogenic AIDs, the skin is frequently involved with a wide range of cutaneous lesions. Monogenic AIDs result from different mutations in a single gene, which regulates the innate immunity. Read More
Eur J Dermatol 2018 Apr;28(2):230-232
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Inflamm Bowel Dis 2018 May;24(6):1167-1184
Center for Inflammatory Bowel Diseases, Digestive Disease and Surgery Institute, The Cleveland Clinic Foundation, Cleveland, Ohio.
Fecal diversion with ostomy construction can be a temporary or definitive surgical measure for the treatment of refractory inflammatory bowel disease (IBD). However, the fecal diversion surgery is associated with various stoma, peristomal complications, and recurrence or occurrence of de novo small bowel Crohn's disease (CD). Stoma complications often need enterostomal therapy or surgical revision. Read More
Am J Clin Dermatol 2018 May 2. Epub 2018 May 2.
Department of Dermatology, University of California Irvine Health, Irvine, CA, USA.
Background: There is little consensus regarding the prevalence and distribution of underlying systemic diseases among patients with pyoderma gangrenosum.
Objective: The objective of this study was to synthesize existing data on the prevalence of associated systemic diseases in patients with pyoderma gangrenosum.
Methods: We performed a systematic review and meta-analysis of observational studies in MEDLINE, EMBASE, and Scopus (1823-2017). Read More
Rheumatol Int 2018 May 2. Epub 2018 May 2.
Dermatology Unit, Department of Physiopathology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
Granulomatosis with polyangiitis (GPA) is a systemic necrotizing small vessel vasculitis associated with circulating anti-neutrophil cytoplasmic antibodies (ANCAs). Skin manifestations, mostly represented by palpable purpura, papulonodular lesions and livedo reticularis, are present in up to 50% of the cases. Ulcerations with undermined, raised erythematous-violaceous border resembling pyoderma gangrenosum (PG) have rarely been reported as skin involvement in GPA. Read More
Dermatopathology (Basel) 2018 Jan-Mar;5(1):14-15. Epub 2018 Feb 2.
Dermatology Unit, IRCCS Cà Granda Foundation, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Plast Reconstr Surg Glob Open 2018 Mar 13;6(3):e1676. Epub 2018 Mar 13.
Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan; Department of Plastic and Reconstructive Surgery, Nippon Medical School, Musashi Kosugi Hospital, Kanagawa, Japan; and Division of Dermatology and Dermatopathology, Nippon Medical School, Musashi Kosugi Hospital, Kanagawa, Japan.
We encountered a case of a man who was diagnosed with severe congenital neutropenia as a child and presented at the age of 45 years with pyoderma gangrenosum (PG) of the lower leg. PG associates with an underlying systemic disease, most commonly inflammatory bowel, rheumatic, or hematological disease or malignancy. However, in many cases, the underlying disease was not known. Read More
J Dermatol 2018 Apr 27. Epub 2018 Apr 27.
Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Indian J Dermatol 2018 Mar-Apr;63(2):91-98
Department of Dermatology, Dr. D. Y. Patil Hospital, Navi Mumbai, Maharashtra, India.
Hidradenitis suppurativa is a chronic, disabling, suppurative disease characterized by deep tender subcutaneous nodules; complicated by fibrosis and extensive sinuses affecting primarily the apocrine gland bearing areas. It affects all races in early 20s with greater prevalence seen in women (3 to 5:1). The estimated disease prevalence is 1 - 4 %. Read More
Inflamm Bowel Dis 2018 Apr;24(5):e16-e17
Island Medical Program, University of Victoria, Victoria, British Columbia, Canada.
Rheumatol Int 2018 Jun 23;38(6):1089-1094. Epub 2018 Apr 23.
Pediatrics Rheumatoloy Unit, Department of Pediatrics, São Paulo Federal University, São Paulo, SP, Brazil.
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. Read More
J Community Hosp Intern Med Perspect 2018 17;8(2):57-59. Epub 2018 Apr 17.
Internal Medicine, Greater Baltimore Medical Center, Baltimore, MD, USA.
This article aims at raising clinical awareness about pyoderma gangrenosum especially when presenting in primary care settings. Due to its initial manifestation as a nonspecific ulcer, physicians with relatively less dermatology experience usually misdiagnose PG as cutaneous infection or vascular disease. This usually leads to inappropriate treatment with subsequent worsening of condition and devastating effects on patients' lives. Read More
G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Background: Skin biopsy is an important tool for various skin conditions. However, in the case of leg ulcers, some Authors still consider it highly risky and mandatory only in selected cases.
Methods: To evaluate the rate of adverse events after leg ulcers biopsy in 866 consecutive patients referring to our Wound Care Unit in Bologna from January 2008 to December 2016. Read More
Inflamm Bowel Dis 2018 Apr 13. Epub 2018 Apr 13.
AbbVie Inc., North Chicago, Illinois.
Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies.
Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016. Read More
Pediatr Dermatol 2018 Apr 15. Epub 2018 Apr 15.
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature. We present a case of infantile pyoderma gangrenosum refractory to topical steroids, tacrolimus, and dapsone as well as systemic steroids and infliximab that is currently well controlled with the addition of oral tacrolimus. To our knowledge, this is the first report of the effective, safe use of oral tacrolimus in combination with infliximab for infantile pyoderma gangrenosum. Read More
J Am Acad Dermatol 2018 Apr 10. Epub 2018 Apr 10.
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders that present with unique clinical features, but are unified by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. The morphology of cutaneous lesions associated with these disorders is heterogeneous, which renders diagnosis challenging. Moreover, a thorough evaluation is required to exclude diseases that mimic these disorders and to diagnose potential associated infectious, inflammatory, and neoplastic processes. Read More
An Bras Dermatol 2018 Jan-Feb;93(1):133-134
Department of Dermatology at Universidad de Buenos Aires - Buenos Aires, Argentina.
Pyoderma gangrenosum may precede, coexist or follow diverse systemic diseases. The bullous variety is usually associated with hematologic disorders. From 31 patients with pyoderma gangrenosum diagnosed in our hospital during 10 years, only 2 presented with the bullous type. Read More
J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
Mansoura Dermatology, Venereology and Leprology Hospital, Mansoura, Egypt. 5-Amien Alsamanoudy Street,from AbdelsalamAaref Street,Mansoura, Egypt.
I read with great interest a review by Gupta et al. published recently in the journal of European Academy of Dermatology and Venereology. The authors reviewed the literatures for the clinical presentation of pyoderma gangrenosum (PG) with pulmonary involvement (PPG). Read More
J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
Oregon Health & Sciences University, Department of Dermatology.
We thank Dr. Abdelmaksoud for his interest in reading our article published on pulmonary pyoderma gangrenosum (PG) recently published in this journal, however we would like to note some inaccuracies in his reporting of our study. Hematologic malignancy was found in 22% of pulmonary pyoderma gangrenosum patients, not 50%. Read More
Wounds 2018 Mar;30(3):57-61
Temple University School of Podiatric Medicine, Philadelphia, PA.
There is evidence in the literature that viable cryopreserved human placental membrane (vCHPM) grafts are effective in treating diabetic foot ulcers and venous leg ulcers.
Objective: This case series presents 3 cases of chronic ulcerations - 1 arterial ulcer (AU), 1 pressure ulcer (PU), and 1 recurrence of a pyoderma gangrenosum ulcer (PGU) - that had failed previous courses of standard wound care and were subsequently treated with vCHPM to determine if the treatment is an effective modality for treating wounds of these etiologies.
Materials And Methods: This retrospective review describes 3 cases in which patients with chronic wounds that had failed standard of care treatments for more than 4 weeks were subsequently treated with weekly applications of vCHPM. Read More
J Dermatol 2018 Mar 25. Epub 2018 Mar 25.
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Am Surg 2018 03;84(3):e112-113
Pan Afr Med J 2017 27;28:180. Epub 2017 Oct 27.
Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire Ibn Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
Cutaneous pathomimia is a self-induced disease characterized by conscious self-injury to mucocutaneous boundary or its phaneres. We report the case of a 22-year old woman, with no notable medical history, presenting with sudden onset ulceration on her lower lip evolving for 3 months in a context of preservation of patient's clinical status. The patient had previously consulted several dermatologists and had undergone two skin biopsies with non-specific histological diagnosis. Read More
JAAD Case Rep 2018 Apr 21;4(3):211-213. Epub 2018 Feb 21.
Department of Dermatology, University of California, San Francisco, San Francisco, California.
Gastroenterol Hepatol 2018 Mar 5. Epub 2018 Mar 5.
Servicio de Aparato Digestivo, Hospital Universitario Central de Asturias, Oviedo, España. Electronic address:
Postepy Dermatol Alergol 2017 Oct 31;34(5):501-503. Epub 2017 Oct 31.
Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Faculty of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.