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J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland.

Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C (CysC), uromodulin (UMOD), and some interleukins (IL-6 and IL-18) can be considered as diagnostic markers of acute kidney injury (AKI). The aim of this study was to verify the applicability of four urinary (u) markers, namely uNGAL, uKIM-1, uCysC, and uUMOD, for the diagnosis of ascending AKI induced by bacterial pyelonephritis. The study included 30 female rats that were divided into three groups (n = 10 each) and were inoculated transurethrally with various doses of Escherichia coli to induce isolated pyelonephritis (group 1, 10 CFU/ml), pyelonephritis-induced AKI (group 2, 10 CFU/ml), or AKI and urosepsis (group 3, 10 CFU/ml). Read More

Clin Kidney J 2018 Dec 2;11(6):769-776. Epub 2018 Jun 2.

Department of Radio Diagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Background: Isolated renal mucormycosis (IRM) is a potentially fatal disease affecting immunocompromised hosts. IRM affecting apparently immunocompetent patients is rare, with few previous reports, mostly from India. We describe 10 cases of bilateral IRM with no underlying risk factors. Read More

Intensive Care Med 2018 Dec 6. Epub 2018 Dec 6.

AIIMS, Rishikesh, Rishikesh, India.

Pediatr Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Dokuz Eylul University, Izmir, Turkey.

Rev Chilena Infectol 2018 Aug;35(4):413-419

Laboratorio de Infectología y Virología Molecular, Pontificia Universidad Católica de Chile, Chile.

Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile.

Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Read More

Am J Case Rep 2018 Dec 10;19:1463-1466. Epub 2018 Dec 10.

Department of Internal Medicine, Haga Teaching Hospital, Hague, Netherlands.

BACKGROUND This is a case report of a male patient who presented with a history of right flank pain based on renal infarction. Initially the symptoms were misdiagnosed as acute pyelonephritis. CASE REPORT A 47-year-old male with a history of familial hypercholesterolemia and cerebral infarction presented at the Emergency Department with a 3-day history of acute right-sided flank pain. Read More

Clin Nephrol 2018 Dec 11. Epub 2018 Dec 11.

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

J Nephrol 2018 12 5. Epub 2018 Dec 5.

Evid Based Complement Alternat Med 2018 5;2018:5968657. Epub 2018 Nov 5.

Suzhou Academy of Wumen Chinese Medicine, Suzhou 215000, China.

Objectives: To investigate the mechanism of the protective effect of Zishenwan on pyelonephritis rats.

Methods: In the rat model of pyelonephritis, protective effects of Zishenwan, the content of secretory immunoglobulin A (SIg A), and interleukins were detected by ELISA. The expressions of TLR4-NFB pathway were detected by Western blot in renal and urinary tract mucosa. Read More

J Vet Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, California.

Background: Ureteral stent and subcutaneous ureteral bypass (SUB) placement are commonly used for managing ureteral obstructions. Urinary tract infection (UTI) is a recognized complication.

Objectives: To determine postoperative incidence of positive urine cultures in cats undergoing ureteral stent and SUB placement and to identify risk factors associated with positive urine cultures. Read More

Front Pediatr 2018 16;6:353. Epub 2018 Nov 16.

Scott Department of Urology, Baylor College of Medicine, Houston, TX, United States.

While small non-obstructive stones in the adult population are usually observed with minimal follow-up, the same guidelines for management in the pediatric population have not been well-studied. We evaluate the clinical outcomes of small non-obstructing kidney stones in the pediatric population to better define the natural history of the disease. In this IRB-approved retrospective study, patients with a diagnosis of kidney stones from January 2011 to March 2017 were identified using ICD9 and ICD10 codes. Read More

J Korean Med Sci 2018 Dec 15;33(49):e317. Epub 2018 Nov 15.

Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

J Korean Med Sci 2018 Dec 12;33(49):e310. Epub 2018 Nov 12.

Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.

Background: Acute pyelonephritis (APN) is one of the most common community-acquired bacterial infections. Recent increases of antimicrobial resistance in urinary pathogens might have changed the other epidemiologic characteristics of APN. The objective of this study was to describe the current epidemiology of APN in Korea, using the entire population. Read More

Jpn J Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine.

A capnophilic Gram-negative rod was recovered from the urine of an octogenarian male patient with acute pyelonephritis. The isolate also demonstrated to produce CTX-M-2-type- extended-spectrum-β-lactamase. Interestingly, the isolate failed to grow on modified Drigalski (BTB) and MacConkey agars even in the CO-enriched atmosphere. Read More

Georgian Med News 2018 Oct(283):76-80

Higher educational establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine.

The article presents a theoretical generalization of the research results the effectiveness of heparisin on the state of the carbohydrate-protein components of the extracellular matrix of connective tissue in liver in patients with non-alcoholic steatohepatitis with obesity I-II degree and chronic kidney disease І-ІІ stage. The purpose of the study is to find out the effectiveness of heparisin (glycyrizine 40 mg, glycine 400 mg, L-cysteine hydrochloride 20 mg) on the state of the carbohydrate-protein components of the extracellular matrix in connective tissue of the liver in patients with non-alcoholic steatohepatitis (NASH) with obesity I-II degree and chronic kidney disease (CKD) І-ІІ stage. 98 patients with NASH on the background of obesity of the I-II degree were examined, including: 52 patients with NASH (I group) (without accompanying CKD), 46 patients with NASH with comorbid CKD І-ІІ stage (II group). Read More

Med Arch 2018 Oct;72(4):272-275

Clinic for Nuclear Medicine, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: The objective of this research was to determine whether vesicoureteral reflux(VUR) was associated with evolution to renal scarring (RS) following a febrile urinary tract infection (UTI) in infants.

Materials And Methods: Our research included 100 infants, ages up to 1 year with a first febrile UTI. The diagnostic was based on results of: laboratory findings, ultrasonography (USG), voiding cystourethrography (VCUG) and initial and control renal scintigraphy (DMSA renal scan) withtechnetiumTcsuccimer (dimercaptosuccinic acid), to assess the acute pyelonephritis (APN), VUR and RS. Read More

Antibiotics (Basel) 2018 Dec 1;7(4). Epub 2018 Dec 1.

School of Medicine, University of South Carolina, Columbia, SC 29209, USA.

An increasing number of reports describing isolates with piperacillin/tazobactam resistance, despite retained cephalosporin susceptibility, suggest further emergence of this phenotypic resistance pattern. In this report, a patient with metastatic breast cancer presented to medical care after two days of chills, nausea, vomiting, reduced oral intake, and generalized weakness. Blood and urine cultures grew as identified by rapid diagnostics multiplex PCR and MALDI-TOF, respectively. Read More

Can Vet J 2018 Oct;59(10):1062-1066

Département de sciences cliniques, Faculté de Médecine Vétérinaire (FMV), Université de Montréal, St-Hyacinthe, Québec J2S 2M2.

A 3-week-old female dairy calf was presented because of severe weakness and diarrhea. Physical examination and ultrasound findings lead to a tentative diagnosis of intestinal obstruction, although serum biochemistry suggested a primary renal disorder. Reassessment of ultrasound images allowed diagnosis of hydronephrosis that had been misdiagnosed probably because of the clinician's biased Bayesian reasoning. Read More

Lancet Infect Dis 2018 Dec 25;18(12):1319-1328. Epub 2018 Oct 25.

Shionogi & Co Ltd, Osaka, Japan.

Background: Carbapenem-resistant Gram-negative bacteria represent the highest priority for addressing global antibiotic resistance. Cefiderocol (S-649266), a new siderophore cephalosporin, has broad activity against Enterobacteriaceae and non-fermenting bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, including carbapenem-resistant strains. We assessed the efficacy and safety of cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections. Read More

J Assoc Physicians India 2018 May;66(5):101

Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi.

J Assoc Physicians India 2018 May;66(5):97-98

Junior Resident, SGRD-IMSAR, Sri Amritsar, Punjab.

Transpl Infect Dis 2018 Nov 25:e13032. Epub 2018 Nov 25.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri.

Ureaplasma urealyticum is a bacterial species correlated with urethritis in healthy individuals and invasive infections in immunocompromised patients. We describe a 20-year-old female with a history of remote heart transplant on everolimus, mycophenolate, and rituximab presenting with progressive urinary tract symptoms, renal failure, and neurologic symptoms. An extensive workup ultimately identified U urealyticum infection, and the patient successfully recovered after a course of azithromycin and doxycycline. Read More

Magn Reson Imaging Clin N Am 2019 Feb 29;27(1):59-75. Epub 2018 Oct 29.

Department of Radiology, Hospital Garcia de Orta, Av. Torrado da Silva, 2805-267 Almada, Portugal; Department of Radiology, Hospital da Luz, Estrada Nacional 10, km 37, Setúbal 2900-722, Portugal. Electronic address:

Urinary tract infection (UTI) is among the most common of bacterial infections. Imaging studies are only required in cases of complicated UTIs. Ultrasound remains the first-line imaging method; however, CT is the gold standard for evaluation of UTIs. Read More

Emerg Infect Dis 2018 Dec;24(12):2262-2269

Enterohemorrhagic Escherichia coli serogroup O80, involved in hemolytic uremic syndrome associated with extraintestinal infections, has emerged in France. We obtained circularized sequences of the O80 strain RDEx444, responsible for hemolytic uremic syndrome with bacteremia, and noncircularized sequences of 35 O80 E. coli isolated from humans and animals in Europe with or without Shiga toxin genes. Read More

CEN Case Rep 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

A 57-year-old woman with pre-dialysis chronic kidney disease (CKD) was hospitalized because of fever and fatigue. On admission, increased inflammatory response and pyuria with bacteriuria were observed. Pyelonephritis was successfully treated with antibiotics, whereas her fatigue continued and she developed progressive hypercalcemia and hyponatremia; serum sodium level, 116 mEq/L and corrected serum calcium level, 13. Read More

Pediatr Clin North Am 2019 Feb;66(1):1-13

Nephrology Section, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Department of Pediatrics, Ohio State University School of Medicine, 700 Children's Drive, Columbus, OH 43210, USA; Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, W308, Columbus, OH 43205, USA. Electronic address:

Urinary tract infection (UTI) is the second most common bacterial infection in children and is considered a public health threat given the mounting rates of antibiotic-resistance among uropathogens. This article highlights recent encouraging developments in UTI research. Further work is necessary to translate the discoveries into accessible, cost-effective technologies that will aid clinicians in real-time decision-making. Read More

J Ultrason 2018 ;18(73):152-157

3rd Department of Gynecology, Medical University of Lublin, Lublin, Poland.

Renal pelvicalyceal dilatation is caused by urine retention in the upper urinary tract. It is referred to as pyelectasis in medical literature. This term does not indicate the cause that leads to the dilatation of and urine retention in the renal pelvicalyceal system. Read More

J Infect Chemother 2018 Nov 15. Epub 2018 Nov 15.

Second Department of Internal Medicine, Nagasaki University, Nagasaki, Japan; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Emphysematous pyelonephritis (EPN) is a life-threatening renal infection characterized by the formation of gas within the renal parenchyma and collecting duct system, as well as perinephric tissues. We herein report a case of bilateral EPN accompanied by the urinary tract infection caused by spherical growth of Candida albicans in a patient with underlying diabetes mellitus and prostate cancer. The diagnosis was assisted by computed tomography, urography, and gram staining. Read More

Neurologia 2018 Nov 13. Epub 2018 Nov 13.

Unidad de Neuropediatría, Departamento de Pediatría, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal.

BMC Infect Dis 2018 Nov 15;18(1):572. Epub 2018 Nov 15.

Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Urinary tract infections (UTIs) are one of the most frequent diseases encountered by humans worldwide. The presence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) harboring several virulence factors, is a major risk factor for inpatients. We sought to investigate the rate of antibiotic resistance and virulence-associated genes among the UPECs isolated from an Iranian symptomatic population. Read More

Tunis Med 2018 Aug - Sep;96(8-09):495-500

Introduction: Xanthogranulomatous pyelonephritis (XGPN) is a particular form of chronic renal suppuration characterized by the destruction of renal parenchyma and its replacement by a granulomatous tissue containing xanthomatous cells.

Objective: To report and describe the main clinical, biological, radiological and therapeutic aspects of xanthogranulomatous pyelonephritis in adults in focal and diffuse forms.

Methods: This was a monocentric retrospective study involving 42 cases of XGPN operated and histologically confirmed between 2005 and 2015. Read More

Front Pediatr 2018 31;6:329. Epub 2018 Oct 31.

Department of Pediatric Surgery, University Teaching Hospital of Tours, Gatien de Clocheville Hospital, Tours, France.

We described the initial experience of four referral centers in the treatment of primary obstructive megaureter (POM) in children, by high-pressure balloon dilatation (HPBD) of the ureterovesical junction with double JJ stenting. We managed a retrospective multicenter study to assess its effectiveness in long-term. We reviewed the medical records of all children who underwent HPBD for POM that require surgical treatment from May 2012 to December 2017 in four different institutions. Read More

Int J Surg Case Rep 2018 Oct 29;53:238-241. Epub 2018 Oct 29.

Urology Department, Hospital de Braga, Braga, Portugal; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. Electronic address:

Introduction: Vesicoureteral reflux (VUR) corresponds to the reflux of urine from the bladder into the upper urinary system. It can be a congenital or an acquired anomaly and although its incidence is high in children it is uncommon in the adult life. One of its presentations in the adult population is the presence of recurrent Pyelonephritis. Read More

J Infect Chemother 2018 Nov 9. Epub 2018 Nov 9.

Japan Development, MSD K.K., Tokyo, Japan. Electronic address:

We report efficacy and safety results for a combination of a novel cephalosporin class antibiotic and a β-Lactamase inhibitor, tazobactam/ceftolozane (1:2) at a dose of 1.5 g intravenously every 8 h in Japanese patients with uncomplicated pyelonephritis and complicated urinary tract infection. This study design was a nonrandomized, multicenter, open-label trial, and the treatment period was 7 days. Read More

Br J Hosp Med (Lond) 2018 Nov;79(11):653

Consultant in Elderly Medicine, Acute Medical Unit, West Suffolk Hospital, West Suffolk NHS Foundation Trust, Bury St Edmunds IP33 2QZ.

Am J Ther 2018 Oct 24. Epub 2018 Oct 24.

Department of Physiology, Applied Physiology Research, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Urinary tract infection and pyelonephritis are clinical problems that frequently occur in children. Several factors are responsible for renal tissue injury, morbidity, and renal scarring after pyelonephritis. The aim of this study was to evaluate the preventive effect of L-carnitine on renal scarring in acute pyelonephritis. Read More

J Clin Invest 2018 Dec 12;128(12):5634-5646. Epub 2018 Nov 12.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

People with diabetes mellitus have increased infection risk. With diabetes, urinary tract infection (UTI) is more common and has worse outcomes. Here, we investigate how diabetes and insulin resistance impact the kidney's innate defenses and urine sterility. Read More

Actas Urol Esp 2018 Nov 8. Epub 2018 Nov 8.

Servicio de Urología, Hospital Universitario y Politécnico La Fe, Valencia, España.

Objective: Infectious complications (IC) following percutaneous nephrolithotomy surgery (PCNL) can be life-threatening. Our objective was to analyse preoperative predictors of IC in PCNL.

Materials And Methods: A total of 203 patients who underwent PCNL were included in a prospective study between January 2013 and February 2016. Read More

Transpl Infect Dis 2018 Nov 9:e13026. Epub 2018 Nov 9.

Department of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, Michigan.

Emphysematous pyelonephritis (EPN) is a rare condition which can rapidly progress to sepsis and multiple organ failure with high mortality. We experienced a rare case of EPN in a renal allograft related to antibody-mediated rejection (AMR). The patient received a deceased donor kidney transplant due to end-stage renal disease secondary to diabetes mellitus. Read More

Medicine (Baltimore) 2018 Nov;97(45):e11272

Department of Nephrology, Qilu Hospital of Shandong University (Qingdao).

Introduction: Emphysematous pyelonephritis (EPN) or cystitis (EC) is a severe infection of the urinary tract with high mortality. EPN is uncommon among the patients of end stage of renal failure (ESRD) CASE PRESENTATION:: A 38-year-old male with uremia and anuria who was on hemodialysis was found to have gas formation in the bilateral pelvis, ureters, and urinary bladder by CT scan. The diagnosis was emphysematous pyelonephritis and cystitis. Read More

J Healthc Eng 2018 14;2018:2986742. Epub 2018 Oct 14.

Bioscience Research Institute, Athlone Institute of Technology, Athlone, Ireland.

Catheter-associated urinary tract infections (CAUTIs) are one of the most common nosocomial infections and can lead to numerous medical complications from the mild catheter encrustation and bladder stones to the severe septicaemia, endotoxic shock, and pyelonephritis. Catheters are one of the most commonly used medical devices in the world and can be characterised as either indwelling (ID) or intermittent catheters (IC). The primary challenges in the use of IDs are biofilm formation and encrustation. Read More

Antimicrob Agents Chemother 2018 Nov 5. Epub 2018 Nov 5.

The Medicines Company, San Diego, California, USA.

Vaborbactam is a novel beta-lactamase inhibitor with activity against important beta-lactamases, in particular, serine carbapenemases, and is currently approved in combination with meropenem as Vabomere™ for the treatment of complicated urinary tract infections, including pyelonephritis. This combination is highly active against Gram-negative pathogens, especially KPC-producing, carbapenem-resistant, The objective of these studies was to evaluate vaborbactam pharmacokinetics (PK) and pharmacodynamics (PD) relationships for efficacy in a neutropenic mouse thigh infection model and as well in an in vitro hollow fiber infection model, in combination with a fixed exposure of meropenem using KPC-containing strains of For both models, the meropenem dosage regimen was designed to simulate a 2 g dose administered every eight hours (q8h) by three hour infusion. Vaborbactam dosage regimens were designed to produce a wide range of 24 hour AUCs in the thigh infection model. Read More

Antimicrob Agents Chemother 2018 Nov 5. Epub 2018 Nov 5.

Department of Pharmacy Services, St. Joseph's Hospital and Medical Center, Phoenix, AZ.

: Increasing bacterial resistance and poor patient adherence rates limit the effectiveness of conventional antibiotic therapies for urinary tract infection (UTI). The objective of this study was to investigate whether a single aminoglycoside dose adequately treated UTI.: A systematic search of PubMed/MEDLINE and Google Scholar databases was performed through September 2018 for English-language original research articles assessing the efficacy of one-time parenteral aminoglycoside as UTI monotherapy. Read More

J Am Coll Radiol 2018 Nov;15(11S):S232-S239

Specialty Chair, University of Alabama at Birmingham, Birmingham, Alabama.

Pyelonephritis refers to infection involving the renal parenchyma and renal pelvis. In most patients, uncomplicated pyelonephritis is diagnosed clinically and responds quickly to appropriate antibiotic treatment. If treatment is delayed, the patient is immunocompromised, or for other reasons, microabscesses that form during the acute phase of pyelonephritis may coalesce, forming a renal abscess. Read More

Arch Dis Child 2018 Nov 2. Epub 2018 Nov 2.

Department of Nephrology, "P&A Kyriakou" Children's Hospital, Athens, Greece.

Objective: To assess the effect of the duration of fever after the initiation of treatment (FAT) of febrile urinary tract infections (UTI) on the development of permanent renal lesions based on dimercaptosuccinic acid (DMSA) scintigraphy findings. To evaluate the FAT contribution to permanent renal lesion formation in relation to fever before treatment initiation (FBT), the presence of vesicourinary reflux (VUR), age and severity of infection.

Methods: The inpatient records of 148 children (median age: 2. Read More

J Med Genet 2018 Nov 1. Epub 2018 Nov 1.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Copa syndrome is a rare autosomal dominant disorder with abnormal intracellular vesicle trafficking. The objective of this work is to expand the knowledge about this disorder by delineating phenotypic features of an unreported COPA family.

Methods And Results: A heterozygous missense variant (c. Read More

Med Mal Infect 2018 Oct 29. Epub 2018 Oct 29.

Unité des maladies infectieuses et tropicales, centre hospitalier Andrée-Rosemon, 97300 Cayenne, French Guiana; Équipe EA 3593, écosystèmes amazoniens et pathologie tropicale, université de la Guyane, 97300 Cayenne, French Guiana. Electronic address:

Objectives: Urinary tract infections (UTIs) have rarely been studied in the Amazon region. We aimed to describe the epidemiology of bacteria causing UTIs in French Guiana.

Patients And Methods: We performed a monocenter retrospective study of adults consulting at the emergency department of Cayenne Hospital in 2014 with a diagnosis of UTI. Read More

Exp Clin Transplant 2018 Oct 24. Epub 2018 Oct 24.

From the Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.

Objectives: Long-term outcomes of kidney transplant recipients with postoperative genitourinary tract infections are not well characterized. In this single center retrospective study, we aimed to investigate the long-term effects of early posttransplant genitourinary infections under a protocol that included 1 month of antibiotic prophylaxis on graft failure and patient outcomes.

Materials And Methods: Electronic medical records of 1752 recipients of kidney-alone transplant between January 2000 and December 2008 were reviewed. Read More

Biomed Khim 2018 Sep;64(5):439-443

Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia.

To clarify the role of the infectious factor in the development of premature birth (PB) in women in serum, the content of TLR-4, the p65 subunit of the nuclear factor NF-kB, the cytokine TNF-a and the activity of PLA2 (phospholipase A2) were determinated by the enzyme immunoassay was studied. The profile of bioregulators in women with premature births was characterized by a high content of TLR-4, TNF-a and an increase in PLA2 activity and a decrease in the activity of the p65 subunit of NF-kB. 89 women aged 20-39 years were examined at 34-40 weeks gestation. Read More

Respirol Case Rep 2018 Dec 21;6(9):e00377. Epub 2018 Oct 21.

Department of Respiratory Medicine Monash Medical Centre Melbourne Australia.

Xanthogranulomatous pyelonephritis (XGP) is a rare chronic granulomatous process that affects the kidneys. It is usually associated with longstanding urinary tract infections and obstruction. Patients suffering from XGP typically present with undifferentiated symptoms, including abdominal pain, weight loss, and intermittent fevers. Read More