4,859 results match your criteria Pyelonephritis Chronic


Developmental stages of tertiary lymphoid tissue reflect local injury and inflammation in mouse and human kidneys.

Kidney Int 2020 May 27. Epub 2020 May 27.

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan. Electronic address:

Tertiary lymphoid tissues (TLTs) are inducible ectopic lymphoid tissues in chronic inflammatory states and function as sites of priming local immune responses. We previously demonstrated that aged but not young mice exhibited multiple TLTs after acute kidney injury and that TLTs were also detected in human aged and diseased kidneys. However, the forms of progression and the implication for kidney injury remain unclear. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.023DOI Listing

Acute on chronic kidney disease in cats: Etiology, clinical and clinicopathologic findings, prognostic markers, and outcome.

J Vet Intern Med 2020 May 22. Epub 2020 May 22.

Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Background: Chronic kidney disease (CKD) and acute decompensation of CKD (ACKD) are common in cats.

Objectives: To characterize the etiology, clinical and clinicopathologic findings, and the short- and long-term prognosis of feline ACKD.

Animals: One hundred cats with ACKD. Read More

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http://dx.doi.org/10.1111/jvim.15808DOI Listing

CT imaging of acute and chronic pyelonephritis: a practical guide for emergency radiologists.

Emerg Radiol 2020 May 22. Epub 2020 May 22.

Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata (BIND), University Hospital "Paolo Giaccone", Via del Vespro, 129, 90127, Palermo, Italy.

Contrast-enhanced CT is not routinely indicated in uncomplicated urinary infections, but it may be necessary in patients with specific risk factors (i.e., diabetes, immunocompromised patients, history of stones, or prior renal surgery) or in patients not responding to antibiotics and in detecting complications of pyelonephritis. Read More

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http://dx.doi.org/10.1007/s10140-020-01788-zDOI Listing

[Consenso Argentino Intersociedades de Infección Urinaria 2018-2019 - Parte I].

Medicina (B Aires) 2020 ;80(3):229-240

Sociedad Argentina de Infectología, Argentina.

The Argentine Society of Infectious Diseases and other scientific societies have updated these recommendations based on data on urinary tract infections in adults obtained from a prospective multicenter study conducted in Argentina during 2016-2017. Asymptomatic bacteriuria should be treated only in pregnant women, who should also be systematically investigated; the antibiotics of choice are nitrofurantoin, amoxicillin, clavulanic/amoxicillin, cephalexin and trimethoprim-sulfamethoxazole. In procedures involving injury to the urinary tract with bleeding, it is recommended to request urine culture and, in the presence of bacteriuria, antimicrobial treatment according to sensitivity should be prescribed from immediately before up to 24 hours after the intervention. Read More

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January 2020
0.421 Impact Factor

Serum creatinine levels in cases of posterior urethral valve: 29 years experience of a pediatric urology reference center.

Low Urin Tract Symptoms 2020 May 19. Epub 2020 May 19.

Department of Urology, University of Health Sciences, Sultan Abdülhamid Han Education and Research Hospital, Istanbul, Turkey.

Objectives: The aim of this retrospective study is to describe the importance of serum creatinine levels for the long-term renal outcome in cases of posterior urethral valve.

Methods: Records of 94 patients who underwent cystoscopic valve ablation were evaluated retrospectively. Demographic variables, radiologic findings, and serum creatinine levels were recorded. Read More

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http://dx.doi.org/10.1111/luts.12316DOI Listing

A Rare Case of Spontaneous Bilateral Subcapsular Renal Hematoma.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620918098

UCLA-Kern Medical, Bakersfield, CA, USA.

Spontaneous bilateral renal subcapsular hematoma is a rare condition. On literature review, only 2 case reports have elucidated possible etiologies for such a presentation; however, no definite conclusions have been made. We present a rare case of a 52-year-old female with diabetes mellitus type 2, chronic kidney disease stage 4, hypertension, hyperlipidemia, prior traumatic brain injury via motor vehicle accident, who presented to our hospital with diabetic ketoacidosis and clinical signs of pyelonephritis; subsequently, imaging demonstrated spontaneous bilateral renal subcapsular hematoma. Read More

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http://dx.doi.org/10.1177/2324709620918098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223858PMC

Kidney dendritic cells: fundamental biology and functional roles in health and disease.

Nat Rev Nephrol 2020 May 5. Epub 2020 May 5.

Division of Translational Immunology, III Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Dendritic cells (DCs) are chief inducers of adaptive immunity and regulate local inflammatory responses across the body. Together with macrophages, the other main type of mononuclear phagocyte, DCs constitute the most abundant component of the intrarenal immune system. This network of functionally specialized immune cells constantly surveys its microenvironment for signs of injury or infection, which trigger the initiation of an immune response. Read More

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http://dx.doi.org/10.1038/s41581-020-0272-yDOI Listing

[Features of chronic kidney disease in elderly patients.]

Authors:
O N Kurochkina

Adv Gerontol 2020 ;33(1):113-120

Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky pr., Syktyvkar 557001, Komi Republic, Russian Federation, e-mail:

The purpose of the work is to study the characteristics of the course of chronic kidney disease in elderly patients based on the analysis of the register of chronic kidney disease (CKD) for 2015-2018. in the Department of Nephrology, the Komi Republican Clinical Hospital. There are 484 patients in the register, of whom 231 are men (47,7%), 253 women (52,3%). Read More

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January 2020

The Dark Purple Side of Ceftriaxone: A Case Report on Leucocytoclastic Vasculitis.

Eur J Case Rep Intern Med 2020 5;7(4):001464. Epub 2020 Mar 5.

Service of Internal Medicine, Ospedale Regionale di Lugano (Italiano), Ente Ospedaliero Cantonale, Lugano, Switzerland.

We present a case of an 85-year-old woman diagnosed with uncomplicated pyelonephritis, who was treated with intravenous ceftriaxone. Her chronic medications were phenprocoumon, diltiazem and bisoprolol. During the infectious phase, the patient presented tachycardia - despite high-dose beta-blocker treatment - and developed left acute heart failure, with acute renal failure (pre-renal origin). Read More

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http://dx.doi.org/10.12890/2020_001464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162562PMC

Safety of dapagliflozin in a broad population of patients with type 2 diabetes: Analyses from the DECLARE-TIMI 58 study.

Diabetes Obes Metab 2020 Apr 2. Epub 2020 Apr 2.

Li Ka Shing Knowledge Institute, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Canada.

Aims: To evaluate comprehensively the safety of dapagliflozin in patients with type 2 diabetes (T2DM), with emphasis placed on potential safety concerns related to the sodium-glucose co-transporter-2 inhibitor class.

Methods: In the Dapagliflozin Effect on Cardiovascular Events - Thrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) study, 17 160 patients with T2DM were randomized to dapagliflozin or placebo and followed for a median of 4.2 years. Read More

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http://dx.doi.org/10.1111/dom.14041DOI Listing

TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis.

Physiol Rep 2020 Mar;8(6):e14401

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

Renal scarring after pyelonephritis is linked to long-term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenic Escherichia coli (UPEC) pyelonephritis and resultant scarring in both male and female mice, while anti-androgen therapy is protective against severe urinary tract infection (UTI) in these models. This work employed androgenized female C57BL/6 mice to elucidate the molecular mechanisms of post-infectious renal fibrosis and to determine how these pathways are altered by the presence of androgens. Read More

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http://dx.doi.org/10.14814/phy2.14401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104652PMC

Preliminary in Vitro Studies on Pathogenetic Mechanisms, a Possible Candidate for Chronic Idiopathic Prostatitis?

Microorganisms 2020 Mar 25;8(4). Epub 2020 Mar 25.

Department of Medicine and Health Sciences "Vincenzo Tiberio", Università degli Studi del Molise-III Ed Polifunzionale, 86100 Campobasso, Italy.

is a well-known opportunistic uropathogen that can occur with cystitis, pyelonephritis, and urinary sepsis. Although a wide variety of coryneform bacteria have been found from the male genital tract of prostatitis patients, only one clinical case of prostatitis caused by has been reported. The aim of this study was to evaluate the tropism of towards LNCaP (lymph node carcinoma of the prostate) human cells line and the influence of acetohydroxamic acid as an irreversible urease inhibitor on different aspects of its pathogenicity by means of several tests, such as the determination and analysis of growth curves, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the production of biofilms, and adhesion to LNCaP and HeLa cell lines. Read More

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http://dx.doi.org/10.3390/microorganisms8040463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232468PMC

High-output cardiac failure secondary to high-output arteriovenous fistula: investigations, management and definitive treatment.

BMJ Case Rep 2020 Feb 28;13(2). Epub 2020 Feb 28.

Cardiology, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool, UK.

A 32 year-old woman was admitted to our institution with progressive dyspnoea. Her medical history was notable for end-stage renal failure secondary to chronic pyelonephritis, and she had undergone a cadaveric renal transplant in 2010. This had been preceded by haemodialysis treatment via a radiocephalic arteriovenous fistula. Read More

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http://dx.doi.org/10.1136/bcr-2019-233669DOI Listing
February 2020

Ultrasonography of the liver in healthy and diseased camels (Camelus dromedaries).

Authors:
Mohamed Tharwat

J Vet Med Sci 2020 Apr 26;82(4):399-407. Epub 2020 Feb 26.

Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, P.O. Box 6622, Buraidah, 51452, Saudi Arabia.

In camels, hepatic diseases are relatively common and most of them are misdiagnosed as a cause of illness because signs may be subtle. In addition, diagnostic laboratory methods are insufficient as hepatic enzymes can also be elevated in camels with cardiac or skeletal muscle damage. Examples of liver diseases in camels are hepatic lipidosis, hepatitis, cirrhosis, hepatic necrosis, choleostasis, hyperplasia of biliary epithelium, hydatid cysts, glycogen deposition, cholangitis, cholangiohepatitis, calcified hydatid cyst and hepatic abscesses. Read More

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http://dx.doi.org/10.1292/jvms.19-0690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192722PMC

Localization of acute pyelonephritis in pyrexia of unknown origin using FDG PET/CT.

Asia Ocean J Nucl Med Biol 2020 ;8(1):79-83

SPECT Lab, Nuclear Medicine Services, Pune, Maharashtra, India.

Objectives: Acute pyelonephritis presents with high-grade fever, dysuria, flank pain, leukocytosis, and microscopic hematuria. Urine culture aids in the diagnosis of this infection. It can be complicated or uncomplicated. Read More

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http://dx.doi.org/10.22038/aojnmb.2019.14242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994777PMC
January 2020

Clinical, morphologic and histological features of chronic pyelonephritis: An 8-year review.

Niger Postgrad Med J 2020 Jan-Mar;27(1):37-41

Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.

Background: Urinary tract infection (UTI), especially pyelonephritis when inadequately treated may culminate in end-stage renal disease. The study aims to evaluate the risk factors for and clinico-pathologic features of chronic pyelonephritis (CPN) among patients in Aminu Kano Teaching Hospital, Kano, in North-Western Nigeria.

Materials And Methods: Data on cases diagnosed as CPN between 2010 and 2017 in the study centre were retrieved from archives and analysed for risk factors and clinic-pathologic features. Read More

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http://dx.doi.org/10.4103/npmj.npmj_109_19DOI Listing

Process Development and Synthesis of Process-Related Impurities of an Efficient Scale-Up Preparation of 5,2'-Dibromo-2,4',5'-Trihydroxy Diphenylmethanone as a New Acute Pyelonephritis Candidate Drug.

Molecules 2020 Jan 22;25(3). Epub 2020 Jan 22.

Beijing Zhendong Guangming Pharmaceutical Research Institute, 18 Chuangye Road, Beijing 100089, China.

Based on a foregoing gram-scale laboratory process, an efficient scale-up preparation process of 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone (), a new acute pyelonephritis candidate drug, was developed and validated aiming to reduce by-products and achieve better impurity profiles. Meanwhile, the polymorph of and process-related impurities were also investigated. Ultimately, the optimal reaction conditions were verified by evaluating the impurity profiles and their formation during the synthesis. Read More

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http://dx.doi.org/10.3390/molecules25030468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037700PMC
January 2020

Case report: Xanthogranulomatous pyelonephritis masquerading as cystic renal cell carcinoma.

Br J Biomed Sci 2020 Apr 24;77(2):87-90. Epub 2020 Jan 24.

Section of Urology, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.

Xanthogranulomatous pyelonephritis (XGP) is a rare chronic bacterial inflammation of the renal parenchyma and is often a diagnostic dilemma. We present a challenging case of a patient with XGP. Initially thought to have had renal cell cancer she was treated accordingly with a partial nephrectomy. Read More

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http://dx.doi.org/10.1080/09674845.2019.1662977DOI Listing

Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis.

Korean J Pediatr 2019 Dec 18;62(12):433-437. Epub 2019 Oct 18.

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Acute pyelonephritis (APN) should be detected and treated as soon as possible to reduce the risk of the development of acquired renal scarring. However, in the medical field, urine culture results are not available or considered when the prompt discrimination of APN is necessary and empirical treatment is started. Furthermore, urine culture cannot discriminate APN among children with febrile urinary tract infection (UTI) (pyelitis, lower UTI with other fever focus). Read More

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http://dx.doi.org/10.3345/kjp.2019.00710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933307PMC
December 2019

Using single-cell technologies to map the human immune system - implications for nephrology.

Nat Rev Nephrol 2020 02 12;16(2):112-128. Epub 2019 Dec 12.

Molecular Immunity Unit, University of Cambridge Department of Medicine, Cambridge, UK.

Advances in single-cell technologies are transforming our understanding of cellular identity. For instance, the application of single-cell RNA sequencing and mass cytometry technologies to the study of immune cell populations in blood, secondary lymphoid organs and the renal tract is helping researchers to map the complex immune landscape within the kidney, define cell ontogeny and understand the relationship of kidney-resident immune cells with their circulating counterparts. These studies also provide insights into the interactions of immune cell populations with neighbouring epithelial and endothelial cells in health, and across a range of kidney diseases and cancer. Read More

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http://dx.doi.org/10.1038/s41581-019-0227-3DOI Listing
February 2020

[Predictors of perioperative complications in children with obstructive uropathy].

Urologiia 2019 Dec(5):98-104

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To identify predictors of perioperative complications in children with obstructive uropathy.

Materials And Methods: A total of 178 patients with obstructive uropathy were divided into 3 groups. In Group 1 there were 108 children with hydronephrosis, while Group 2 included 47 children with ureterohydronephrosis and Group 3 consisted of 23 children with bladder outlet obstruction according to the results of clinical, laboratory, microbiological, X-ray and pathologic study. Read More

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December 2019

Urinary tract infection in pediatrics: an overview.

J Pediatr (Rio J) 2020 Mar - Apr;96 Suppl 1:65-79. Epub 2019 Nov 26.

University of California, Rady Children's Hospital San Diego, Division of Pediatric Nephrology, San Diego, United States.

Objective: This review aimed to provide a critical overview on the pathogenesis, clinical findings, diagnosis, imaging investigation, treatment, chemoprophylaxis, and complications of urinary tract infection in pediatric patients.

Source Of Data: Data were obtained independently by two authors, who carried out a comprehensive and non-systematic search in public databases.

Summary Of Findings: Urinary tract infection is the most common bacterial infection in children. Read More

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http://dx.doi.org/10.1016/j.jped.2019.10.006DOI Listing
November 2019

Stability and profiling of urinary microRNAs in healthy cats and cats with pyelonephritis or other urological conditions.

J Vet Intern Med 2020 Jan 13;34(1):166-175. Epub 2019 Nov 13.

Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark.

Background: Specific biomarkers of pyelonephritis (PN) in cats are lacking. MicroRNAs (miRNAs) have diagnostic potential in human nephropathies.

Objectives: To investigate the presence/stability of miRNAs in whole urine of cats and the discriminatory potential of selected urinary miRNAs for PN in cats. Read More

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http://dx.doi.org/10.1111/jvim.15628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979273PMC
January 2020

Identifying priorities for primary care investment in Ireland through a population-based analysis of avoidable hospital admissions for ambulatory care sensitive conditions (ACSC).

BMJ Open 2019 11 5;9(11):e028744. Epub 2019 Nov 5.

Planning for Health Group, Department of Public Health, HSE West, Health Services Executive, Galway, Ireland.

Background: In 2016, the Irish acute hospital system operated well above internationally recommended occupancy targets. Investment in primary care can prevent hospital admissions of ambulatory care sensitive conditions (ACSCs).

Objective: To measure the impact of ACSCs on acute hospital capacity in the Irish public system and identify specific care areas for enhanced primary care provision. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858209PMC
November 2019

Aminoglycoside versus carbapenem or piperacillin/tazobactam treatment for bloodstream infections of urinary source caused by Gram-negative ESBL-producing Enterobacteriaceae.

J Antimicrob Chemother 2020 Feb;75(2):458-465

Infectious Disease Unit, Wolfson Medical Center, Holon, Israel.

Objectives: We studied the performance of aminoglycosides in treating bloodstream infections (BSIs) of urinary source caused by ESBL-producing Enterobacteriaceae (ESBL-EB).

Methods: In a retrospective study of 193 patients with a clinical diagnosis of urinary tract infection, pyelonephritis or urosepsis and blood and urine cultures positive for ESBL-EB, patients were grouped according to whether they were treated with an aminoglycoside, a carbapenem or piperacillin/tazobactam. Multivariate analysis was used to define risk factors for mortality with inverse probability of treatment weighting used to minimize confounding. Read More

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http://dx.doi.org/10.1093/jac/dkz457DOI Listing
February 2020
1 Read

ABILITY TO FORM BIOFILMS BY PYELONEPHRITIS CAUSATIVE AGENTS IN CHILDREN.

Georgian Med News 2019 Sep(294):132-136

Kharkiv National Medical University, 1D.P. Grynyov Department of Microbiology, Virology and Immunology.

The work is dedicated to the study of biofilms formation process by main pyelonephritis causative agents in children in vitro using methods of light, fluorescent and scanning microscopy. To study biofilms formation bacteria were cultivated in liquid substratum on glass in polystyrene Petri dishes d=40mm. The study demonstrated that all isolates formed biofilms. Read More

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September 2019

Effects on renal outcome of concomitant acute pyelonephritis, acute kidney injury and obstruction duration in obstructive uropathy by urolithiasis: a retrospective cohort study.

BMJ Open 2019 11 3;9(11):e030438. Epub 2019 Nov 3.

Internal Medicine, Chung-Ang University Hospital, Seoul, Korea

Objective: Obstruction release from urolithiasis can be delayed with a lack of suggested time for preventing the deterioration of renal function. The objective of this study was to investigate the effect of obstruction duration, concomitant acute kidney injury (AKI) or acute pyelonephritis (APN) during the obstruction on the prognosis of renal function.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-030438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858199PMC
November 2019

Urinary tract infection and subclinical bacteriuria in cats: A clinical update.

J Feline Med Surg 2019 11 10;21(11):1023-1038. Epub 2019 Oct 10.

Small Animal Section, Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, PO Box 369 Sentrum, 0102 Oslo, Norway.

Practical Relevance: Urinary tract infection (UTI) is an important cause of feline lower urinary tract disease (FLUTD), particularly in female cats older than 10 years of age. In addition to cats with typical clinical signs of FLUTD or upper UTI, many cats have subclinical bacteriuria, but the clinical relevance of this is currently uncertain. UTIs are one of the most important indications for antimicrobial use in veterinary medicine and contribute to the development of antimicrobial resistance. Read More

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http://dx.doi.org/10.1177/1098612X19880435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826873PMC
November 2019
5 Reads

Inadequate empirical antimicrobial treatment in older people with bacteremic urinary tract infection who reside in nursing homes: A multicenter prospective observational study.

Geriatr Gerontol Int 2019 Nov 1;19(11):1112-1117. Epub 2019 Oct 1.

Department of Internal Medicine, Hospital Universitario Dr. Peset. Universitat de València, València, Spain.

Aim: The aim of the study was to determine the rate of inadequate empirical antimicrobial treatment in older nursing home residents with bacteremic urinary tract infection and its influence on prognosis.

Methods: We carried out a multicentric prospective observational study in five Spanish hospitals. Patients aged >65 years with pyelonephritis or urinary sepsis with bacteremia were included. Read More

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http://dx.doi.org/10.1111/ggi.13776DOI Listing
November 2019
1 Read

Isolation and structural determination of flavan-3-ol derivatives from the L. rhizomes water extract.

Nat Prod Res 2019 Aug 21:1-10. Epub 2019 Aug 21.

Department of Pharmacognosy and Herbal Medicines, Wroclaw Medical University , Wrocław , Poland.

L. (Polypodiaceae) is a fern used in traditional Polish medicine as an expectorant to treat cough and pertussis. Additionally, it was used as a diuretic in renal diseases, especially in chronic nephritis and pyelonephritis. Read More

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http://dx.doi.org/10.1080/14786419.2019.1655302DOI Listing
August 2019
2 Reads

Imaging Manifestations of Acute and Chronic Renal Infection That Mimics Malignancy: How to Make the Diagnosis Using Computed Tomography and Magnetic Resonance Imaging.

Can Assoc Radiol J 2019 Nov 17;70(4):424-433. Epub 2019 Sep 17.

Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

Purpose: To review the computed tomography and magnetic resonance imaging manifestations of acute and chronic renal infections that may mimic malignancy and to provide useful tips to establish an imaging diagnosis.

Conclusion: Acute and chronic bacterial pyelonephritis are usually readily diagnosed clinically and on imaging when the diagnosis is suspected based upon clinical presentation. When unsuspected, focal, extensive or mass-like, acute and chronic bacterial pyelonephritis may mimic infiltrative tumours such as urothelial cell carcinoma (UCC), lymphoma, and metastatic disease. Read More

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http://dx.doi.org/10.1016/j.carj.2019.07.002DOI Listing
November 2019
3 Reads

[Prevention of perioperative complications in children with congenital uropathies].

Urologiia 2019 Sep(4):85-90

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To substantiate the expediency of immunomodulators and probiotics application pathogenetically in the comprehensive preoperative preparation in children with congenital uropathies (U).

Materials And Methods: The study includes 60 patients with various types of congenital uropathy (CU) (vesicoureteral reflux, hydronephrosis, obstructive ureterohydronephrosis), which were divided into 3 groups in accordance with the preoperative preparation complex. 1 group - 20 patients with VU, immunomodulating drug Kipferon was added to the therapy at the preoperative stage, group 2 - 20 patients with VU - with the addition of the biologically active additive (BAA) "Bifidum No791 BAG", 3 control group - 20 children with VU standard complex of preoperative preparation. Read More

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September 2019
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Antimicrobial Susceptibility Patterns and Clinical Parameters in 208 Dogs with Positive Urine Cultures (2012-2014).

J Am Anim Hosp Assoc 2019 Nov/Dec;55(6):306-313. Epub 2019 Sep 16.

From Affiliated Veterinary Specialists, Orlando, Florida (D.A.M.); Department of Veterinary Clinical Sciences (F.G.), and Department of Pathobiological Sciences (A.R.), Louisiana State University School of Medicine, Baton Rouge, Louisiana.

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http://dx.doi.org/10.5326/JAAHA-MS-6796DOI Listing
September 2019
2 Reads

Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report.

Medicine (Baltimore) 2019 Sep;98(36):e17049

Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Research Institute of Clinical Medicine of Chonbuk National University, Department of Orthopedic Surgery.

Rationale: Although chronic pyelonephritis and urolithiasis are established risk factors for squamous cell carcinoma (SCC), only a minority of patients with chronic urolithiasis eventually develop SCC. It is believed that the chronic irritation leads to squamous cell metaplasia that may subsequently develop into SCC. Although studies show that SSC generally spreads locally with associated symptoms of lymphadenopathy, metastasis to the lungs and liver have also been reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000017049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739005PMC
September 2019
3 Reads

Comparison of kidney densities of cases with urinary dilatation in unenhanced CT scan.

Pol J Radiol 2019 5;84:e269-e273. Epub 2019 Jun 5.

Department of Radiology, Mugla Sitki Kocman University, Faculty of Medicine, Muğla, Turkey.

Purpose: The aim of this study was to investigate the diagnostic value of renal parenchymal density differences in distinguishing between acute and chronic urinary dilatations.

Material And Methods: Retrospectively, unenhanced CTs of 98 patients were evaluated. Thirty-three had acute urinary obstruction, and 33 had chronic urinary obstruction. Read More

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http://dx.doi.org/10.5114/pjr.2019.86822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717939PMC
June 2019
1 Read

Xanthogranulomatous Pyelonephritis Causing Renocolic Fistula Presenting as Symptomatic Anemia.

Cureus 2019 Jun 19;11(6):e4947. Epub 2019 Jun 19.

Internal Medicine, University of Missouri-Kansas City l Saint Luke's Health System, Kansas City, USA.

Renocolic fistula is a rare clinical finding that is most commonly iatrogenic after surgical intervention. Herein, we present a case of renocolic fistula secondary to xanthogranulomatous pyelonephritis (XGP) with a subtle presentation as anemia. A 40-year-old female was found to have a hemoglobin of 6. Read More

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http://dx.doi.org/10.7759/cureus.4947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701887PMC
June 2019
2 Reads

Maternal and fetal outcomes in pregnancies with long-term corticosteroid use.

J Matern Fetal Neonatal Med 2019 Aug 20:1-8. Epub 2019 Aug 20.

Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University , Montreal , Canada.

Long-term corticosteroids are administered in pregnant patients with an array of autoimmune and inflammatory disorders. Our objective is to determine whether long-term corticosteroid use is associated with increased maternal and neonatal adverse outcomes. We performed a retrospective cohort study using the Healthcare Cost and Utilization Project-national Inpatient Sample from the USA. Read More

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http://dx.doi.org/10.1080/14767058.2019.1649392DOI Listing
August 2019
2 Reads

Extremely Elevated International Normalized Ratio in a Patient with Dabigatran Etexilate Use.

Cureus 2019 Jun 15;11(6):e4906. Epub 2019 Jun 15.

Osteopathic Medicine, Edward Via College of Osteopathic Medicine, Blacksburg, USA.

A 76-year-old male with a past medical history (PMH) of hypertension, type 2 diabetes mellitus, chronic kidney disease (CKD) stage three, chronic nonvalvular atrial fibrillation (AF) on anticoagulation, and status post-left-sided nephrectomy in 2000 for acute pyelonephritis presented with multiple episodes of epistaxis and shortness of breath. On exam, the patient was afebrile and saturating 95% on room air. There was crusted blood present in bilateral nares along with a 6 x 3-centimeter area of ecchymosis present on the lateral aspect of the right abdominal wall. Read More

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http://dx.doi.org/10.7759/cureus.4906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689472PMC
June 2019
5 Reads

Community Acquired AKI: A Prospective Observational Study from a Tertiary Level Hospital in Southern India.

Indian J Nephrol 2019 Jul-Aug;29(4):254-260

Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Introduction: Pattern of acute kidney injury (AKI) differs vastly from region to region in India. Moreover, prospective data on community-acquired AKI (CAAKI) using the KDIGO criteria for AKI are limited. Our objective was to study the etiology, clinical characteristics, and short-term outcome of CAAKI in adults. Read More

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http://dx.doi.org/10.4103/ijn.IJN_238_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668316PMC
August 2019
2 Reads

Investigation of epigenetics in kidney cell biology.

Methods Cell Biol 2019 13;153:255-278. Epub 2019 Jun 13.

Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Epigenetics is the study of heritable changes in DNA or its associated proteins except mutations in gene sequence. Epigenetic regulation plays fundamental roles in the processes of kidney cell biology through the action of DNA methylation, chromatin modifications via epigenetic regulators and interaction via transcription factors, and noncoding RNA species. Kidney diseases, including acute kidney injury, chronic kidney disease, nephritic and nephrotic syndromes, pyelonephritis and polycystic kidney diseases are driven by aberrant activity in numerous signaling pathways in even individual kidney cell. Read More

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http://dx.doi.org/10.1016/bs.mcb.2019.04.015DOI Listing
May 2020
2 Reads

Correlation of Thyroid Hormone Profile with the Acute Physiology and Chronic Health Evaluation II Score as a Prognostic Marker in Patients with Sepsis in the Intensive Care Unit.

J Assoc Physicians India 2018 Jul;66(7):59-62

Senior Resident, Department of Medicine, Jawaharlal Nehru Medical College, Belgaum, Karnataka.

Objectives: Thyroid hormones regulate metabolism and homeostasis, and variations in thyroid hormone levels are common in chronically ill patients. Thyroid dysfunction, especially in critically ill patients admitted to the intensive care unit (ICU), is associated with adverse outcomes. This study was conducted to find a correlation between thyroid profile and sepsis and associate it with the acute physiology and chronic health evaluation II (APACHE II) score. Read More

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July 2018
2 Reads

[Clinical Features of Comorbid Cluster and Premorbidly Manifestations in Patients with High Vascular Risk in the Middle Age Category with the Presence of Multifocal Atherosclerosis].

Kardiologiia 2019 Jul 19;59(7):31-36. Epub 2019 Jul 19.

Institute of Immunology Federal Medical-Biological Agency of Russia.

Objective: to study clinical and cluster features of cardiovascular burdening taking into account the comorbid polymorbid background in patients of middle age (45-60 years) with the presence of multifocal atherosclerosis (MFA).

Materials And Methods: Patients were examined in the Regional Vascular Center of Ufa (RVCU). Depending on the predominant localization of lesions in the vascular bed patients were divided into 3 clusters by the method of hierarchical analysis of categorical variables according to the clinical manifestation of atherosclerotic lesions of the heart, brain and lower limb arteries confirmed by coronary angiography, ultrasound Doppleroscopy of main arteries of the head and lower extremities. Read More

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http://dx.doi.org/10.18087/cardio.2019.7.n599DOI Listing
July 2019
6 Reads

Chronic kidney disease in preeclamptic patients: not found unless searched for-Is a nephrology evaluation useful after an episode of preeclampsia?

J Nephrol 2019 Dec 17;32(6):977-987. Epub 2019 Jul 17.

Centre Hospitalier Le Mans, Avenue Roubillard 196, 7200, Le Mans, France.

Background: Preeclampsia (PE) and chronic kidney disease (CKD) are linked by an only partially known cause-effect relationship. Knowledge on prevalence of CKD in PE patients is needed for evaluating the diagnostic yield of nephrology work-up after PE.

Methods: The study was undertaken in the Centre Hospitalier Le Mans (CHM), setting of tertiary level obstetric service (about 3500 deliveries/year). Read More

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http://dx.doi.org/10.1007/s40620-019-00629-8DOI Listing
December 2019
4 Reads

Analysis of proteinuria in experimental model of ascending acute kidney injury.

Pol Merkur Lekarski 2019 Jun;46(276):233-238

Department of Pharmacology, Andrzej Frycz Modrzewski Cracow University, Poland.

Proteinuria accompanies kidney diseases of various etiology and correlates with the degree of organ damage. Analysis of proteinuria allows the location of pathophysiological process in the kidney, and assessment of the severity of the kidney disease in chronic and acute kidney injury (AKI). Ascending bacterial acute kidney injury develops as a consequence of pyelonephritis. Read More

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June 2019
5 Reads

Gas in the kidney in asymptomatic urinary tract infections in a patient with severe vesicoureteral reflex.

Saudi J Kidney Dis Transpl 2019 May-Jun;30(3):706-709

Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia.

Diabetes mellitus (DM) is a common disease in Oman as in rest of Gulf Cooperation Council where metabolic syndrome is of high prevalence. DM is a foremost risk factor for urinary tract infections (UTIs). It is also linked to more complicated infections such as emphysematous pyelonephritis (EPN), emphysematous pyelitis (EP), renal/perirenal abscess, emphysematous cystitis, xanthogranulomatous pyelonephritis, and renal papillary necrosis. Read More

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http://dx.doi.org/10.4103/1319-2442.261351DOI Listing
January 2020
13 Reads

Trend of antibiotics usage for acute pyelonephritis in Korea based on national health insurance data 2010-2014.

BMC Infect Dis 2019 Jun 25;19(1):554. Epub 2019 Jun 25.

Department of Internal Medicine, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.

Background: The objective of this study is to describe the changes in prescribing practices of antibiotics to treat acute pyelonephritis (APN) in Korea.

Methods: The claim data base of the Health Insurance Review and Assessment Service in Korea was used to select patients with ICD-10 codes N10 (acute tubulo-interstitial nephritis) or N12 (tubulo-interstitial nephritis, not specified as acute nor chronic) as the primary discharge diagnosis during 2010-2014. Consumption of each class of antibiotics was converted to Defined Daily Dose (DDD)/event. Read More

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http://dx.doi.org/10.1186/s12879-019-4191-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593604PMC
June 2019
5 Reads

Neutrophil-to-Lymphocyte Ratio in Renal Cell Carcinoma Patients.

Folia Med (Plovdiv) 2018 Dec;60(4):553-557

Department of Urology, Haydarpaşa Numune Training and Research Hospital.

Background: Renal cell carcinoma is the third most common cancer after prostate and bladder tumors in urological malignancies. Recently, because of the widespread use of ultrasound and computed tomography, incidental and early stage renal tumors have been encountered more frequently.

Aim: In this study, we evaluated the diagnostic efficacy of neutrophil-to-lymphocyte ratio for the diagnosis of renal cell carcinoma in patients who underwent nephrectomy operation. Read More

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http://dx.doi.org/10.2478/folmed-2018-0037DOI Listing
December 2018
8 Reads