2,718 results match your criteria Pure Red Cell Aplasia


Aberrant splicing due to a novel RPS7 variant causes Diamond-Blackfan Anemia associated with spontaneous remission and meningocele.

Int J Hematol 2020 Aug 9. Epub 2020 Aug 9.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, BMC Box 815, Uppsala, Sweden.

Diamond-Blackfan Anemia (DBA) is a congenital pure red cell aplasia caused by heterozygous variants in ribosomal protein genes. The hematological features associated with DBA are highly variable and non-hematological abnormalities are common. We report herein on an affected mother and her daughter presenting with transfusion-dependent anemia. Read More

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http://dx.doi.org/10.1007/s12185-020-02950-6DOI Listing

Long-term Safety of Epoetin Alfa-epbx for the Treatment of Anemia in ESKD: Pooled Analyses of Randomized and Open-label Studies.

Kidney Med 2019 Sep-Oct;1(5):271-280. Epub 2019 Aug 28.

Houston Methodist Hospital, Houston, TX.

Rationale & Objective: Epoetin alfa-epbx is a biosimilar to the reference product, epoetin alfa. We compare the safety of epoetin alfa-epbx versus epoetin alfa based on a pooled analysis of findings from 2 randomized, double-blind, comparative clinical studies, and report new data for the long-term safety of epoetin alfa-epbx.

Study Design: Pooled analyses of previously conducted studies. Read More

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http://dx.doi.org/10.1016/j.xkme.2019.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380401PMC

Effective treatment of refractory acquired pure red blood cell aplasia with eltrombopag and sirolimus: a case report.

Ther Adv Hematol 2020 20;11:2040620720940144. Epub 2020 Jul 20.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Shuaifuyuan No. 1, Dongcheng District, Beijing 100730, China.

Acquired pure red cell aplasia (aPRCA) is a kind of anemia characterized by severe reticulocytopenia and reduced bone marrow erythroblastic cells. For patients who are refractory to the first-line therapy (cyclosporin A with/without glucocorticoids), second-line therapy is considered less effective. We report on a patient with primary aPRCA who was refractory to cyclosporin A, glucocorticoids, and several second-line regimens. Read More

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http://dx.doi.org/10.1177/2040620720940144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372523PMC

Dysregulation in B cell responses and T follicular helper cell function in ADA2 deficiency patients.

Eur J Immunol 2020 Jul 24. Epub 2020 Jul 24.

Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Adenosine Deaminase 2 Deficiency (DADA2) is an autoinflammatory disease characterized by inflammatory vasculopathy, early strokes associated often with hypogammaglobulinemia. Pure red cell aplasia, thrombocytopenia, and neutropenia have been reported. The defect is due to biallelic loss of function of ADA2 gene, coding for a protein known to regulate the catabolism of extracellular adenosine. Read More

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http://dx.doi.org/10.1002/eji.202048549DOI Listing

Antibody-mediated pure red cell aplasia related with epoetin-beta pegol (C.E.R.A.) as an erythropoietic agent: case report of a dialysis patient.

BMC Nephrol 2020 Jul 14;21(1):275. Epub 2020 Jul 14.

Department of Nephrology, Kyoto Yamashiro General Medical Center, 1-27 Kizuekimae, Kizugawa, Kyoto, 619-0214, Japan.

Background: Erythropoietin-stimulating agents (ESAs) are used to treat anemia in patients with chronic kidney disease, enabling maintenance of stable hemoglobin levels and eliminating the need for multiple transfusions. Epoetin-beta pegol (C.E. Read More

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http://dx.doi.org/10.1186/s12882-020-01934-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362491PMC

Effects of ABO incompatibility in allogeneic hematopoietic stem cell transplantation.

Transfus Clin Biol 2020 Jul 10. Epub 2020 Jul 10.

Department of Hematology, Ankara University School of Medicine, 06590 Dikimevi/Ankara, Turkey.

Introduction: The impact of ABO mismatch on outcomes following allo-HSCT remains controversial. In this study, our aim is to define the effect of ABO mismatch on post-transplant outcomes, engraftment kinetics and complications in a large cohort.

Patients And Methods: We retrospectively identified 1000 patients who underwent allo-HSCT from either bone marrow or peripheral blood stem cells at our center between 1988 and 2016. Read More

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http://dx.doi.org/10.1016/j.tracli.2020.06.008DOI Listing

Daratumumab for pure red cell aplasia post ABO incompatible allogeneic hematopoietic stem cell transplant for aplastic anemia.

Blood Cells Mol Dis 2020 Jul 2:102464. Epub 2020 Jul 2.

Division of Hematology and Bone Marrow Transplant, Max Super-speciality Hospital, India.

Pure red cell aplasia is a known complication after ABO incompatible stem cell transplant. Due to rarity of disease, no established treatment guidelines are available for PRCA. Daratumumab is a monoclonal antibody against CD38 expressed by plasma cells. Read More

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http://dx.doi.org/10.1016/j.bcmd.2020.102464DOI Listing

Late-Onset EBV Susceptibility and Refractory Pure Red Cell Aplasia Revealing DADA2.

J Clin Immunol 2020 Aug 8;40(6):948-953. Epub 2020 Jul 8.

Department of Internal Medicine, Hôpital Estaing, 1 Place Lucie Aubrac, 63000, Clermont-Ferrand, France.

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http://dx.doi.org/10.1007/s10875-020-00812-8DOI Listing

A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1.

Mol Med Rep 2020 Aug 12;22(2):1285-1294. Epub 2020 Jun 12.

Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.

Autoimmune polyendocrine syndrome type 1 (APS‑1) is a rare inherited autoimmune disease, characterized by a classic triad, including chronic mucocutaneous candidiasis, primary adrenocortical insufficiency and hypoparathyroidism. The present study investigated phenotypes and pathogenic variants in a Chinese woman with non‑classical APS‑1. Disease‑associated variants in a patient with APS‑1 were identified via targeted next generation sequencing and the variant was confirmed via Sanger sequencing. Read More

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http://dx.doi.org/10.3892/mmr.2020.11227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339480PMC

[Pure red cell aplasia of the bone marrow in combination with thymoma. A literature review and own data].

Ter Arkh 2019 Jul 15;91(7):121-126. Epub 2019 Jul 15.

Loginov Moscow Clinical Scientific Center.

Eight patients were observed with a rare combination of thymoma and pure red cell aplasia of bone marrow (PRCA), of which seven women were between 44 to 68 years old. The diagnosis of PRCA was established before the detection of thymoma in 1 patient, simultaneously in 3, after - in 4. Seven patients underwent timomectomy. Read More

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http://dx.doi.org/10.26442/00403660.2019.07.000326DOI Listing

Gene mutation profile in patients with acquired pure red cell aplasia.

Ann Hematol 2020 Aug 27;99(8):1749-1754. Epub 2020 Jun 27.

Department of Hematology, Peking union medical college hospital, Chinese academy of medical sciences and Peking union medical college, Beijing, 100730, China.

Acquired pure red cell aplasia (PRCA) is a disorder characterized by normocytic anemia associated with reticulocytopenia and an absence of erythroblasts. The gene mutation profile in acquired PRCA is not defined yet. In this study, we aimed to identify the gene mutation spectrum of patients with acquired PRCA and the correlation between gene mutations and response to immunosuppressive therapy (IST). Read More

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http://dx.doi.org/10.1007/s00277-020-04154-8DOI Listing

ABO incompatibile graft management in pediatric transplantation.

Bone Marrow Transplant 2020 Jun 27. Epub 2020 Jun 27.

Hospital for Children and Adolescents, Stammzelltransplantation und Immunologie, Klinik für Kinder- und Jugendmedizin, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor's RBCs have antigens missing on the recipient's cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. Read More

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http://dx.doi.org/10.1038/s41409-020-0981-7DOI Listing

Pure Red Cell Aplasia Related to Parvovirus B19 Infection in Simultaneous Pancreas and Kidney Recipient: A Case Report.

Transplant Proc 2020 Jun 24. Epub 2020 Jun 24.

Department of Transplantation Medicine, Nephrology and Internal Medicine, Medical University of Warsaw, Poland.

A 42-year-old woman received a simultaneous pancreas and kidney transplantation (SPK). Immunosuppression consisted of tacrolimus modified release, prednisone, mycophenolate mofetil (MMF), and thymoglobulin as induction. The function of both grafts was good. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.127DOI Listing

Coincidence of autoimmune hemolytic anemia and pure red cell aplasia in a patient with CLL.

Ann Hematol 2020 Jun 16. Epub 2020 Jun 16.

Department of Medicine, University of Washington Medical Center, 825 Eastlake Ave E, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s00277-020-04091-6DOI Listing
June 2020
2.634 Impact Factor

Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review.

Case Rep Hematol 2020 13;2020:7819321. Epub 2020 Jan 13.

Internal Medicine Service, Federal University of Pernambuco, Recife, PE, Brazil.

Thymus neoplasms are frequently related to paraneoplastic autoimmune manifestations. Its most common associations are myasthenia gravis and pure red cell aplasia. Aplastic anemia has been increasingly documented as an initial presentation of thymoma. Read More

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http://dx.doi.org/10.1155/2020/7819321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201839PMC
January 2020

Immunosuppression therapy is effective for both acquired tumor-associated and primary pure red cell aplasia: a match pair case-control study.

Ann Hematol 2020 Jul 1;99(7):1485-1491. Epub 2020 Jun 1.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

No agreement had been reached on the treatment of patients with pure red cell aplasia (PRCA) secondary to indolent malignancies. Data was collected from patients with acquired PRCA from May, 2014 to May, 2018 in Peking Union Medical College Hospital. Tumor-associated PRCA and primary PRCA patients were matched at a ratio of 1:2 with compatible baseline characteristics. Read More

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http://dx.doi.org/10.1007/s00277-020-04105-3DOI Listing
July 2020
2.634 Impact Factor

Clusters in Pediatric Rheumatic Diseases.

Curr Rheumatol Rep 2020 May 20;22(7):28. Epub 2020 May 20.

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey.

Purpose Of The Review: Rheumatic diseases usually have very diverse and complex pathophysiology resulting in different clinical phenotypes. Some certain phenotypes cluster together with a common presentation, course, and outcome. Our primary aim is to review the known disease clusters in certain rheumatological conditions. Read More

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http://dx.doi.org/10.1007/s11926-020-00908-5DOI Listing
May 2020
2.454 Impact Factor

New Insights of Human Parvovirus B19 in Modulating Erythroid Progenitor Cell Differentiation.

Viral Immunol 2020 May 15. Epub 2020 May 15.

Pediatrics Department, Children Digital and Health Data Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.

Human parvovirus B19 (B19), a human pathogen of the erythroparvovirus genus, is responsible for a variety of diseases. B19 cause less symptoms in healthy individuals, also cause acute and chronic anemia in immunodeficiency patients. Transient aplastic crisis and pure red cell aplasia are two kinds of anemic hemogram, respectively, in acute and chronic B19 infection phase, especially occurring in patients with a shortened red cell survival or with immunodeficiency. Read More

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http://dx.doi.org/10.1089/vim.2020.0013DOI Listing

Recurrent Pregnancy-Related Pure Red Cell Aplasia Responsive To Combined Corticosteroid And Azathioprine Therapy: A Management Dilemma.

Turk J Haematol 2020 May 12. Epub 2020 May 12.

Department of Obstetrics and Gynecology, Salem Polyclinic, Salem, Tamil Nadu, India.

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http://dx.doi.org/10.4274/tjh.galenos.2020.2020.0170DOI Listing

Pembrolizumab-induced Pure Red Cell Aplasia Successfully Treated with Intravenous Immunoglobulin.

Intern Med 2020 May 8. Epub 2020 May 8.

Department of Hematology, National Hospital Organization Shibukawa Medical Center, Japan.

We herein report a 64-year-old man who was treated with pembrolizumab for relapsed Hodgkin lymphoma. After the third administration of pembrolizumab, he showed acute anemia with a positive direct anti-globulin test. Because of the markedly erythroid hypoplasia, he was diagnosed with pure red cell aplasia (PRCA) caused by pembrolizumab. Read More

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http://dx.doi.org/10.2169/internalmedicine.4467-20DOI Listing

Deficiency of adenosine deaminase 2: Is it an elephant after all?

J Allergy Clin Immunol 2020 Jun 27;145(6):1560-1561. Epub 2020 Apr 27.

National Human Genome Research Institute, National Institutes of Health, Bethesda, Md.

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http://dx.doi.org/10.1016/j.jaci.2020.04.023DOI Listing

Favorable outcomes of hematopoietic stem cell transplantation in children and adolescents with Diamond-Blackfan anemia.

Blood Adv 2020 Apr;4(8):1760-1769

Robert Debré Hospital, Groupe Hospitalier, Assistance Publique-Hôpitaux de Paris Nord, Université de Paris, Paris, France.

Diamond-Blackfan anemia (DBA) is a congenital pure red cell aplasia associated with congenital abnormalities and cancer predisposition. Allogeneic hematopoietic stem cell transplantation (HSCT) can correct the hematological phenotype and is indicated in transfusion-dependent patients. In 70 children reported to the German DBA and French HSCT registries, HSCT was performed from 1985 to 2017. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189291PMC

[Efficacy of Oral Cyclophosphamide for Treatment of Refractory T-cell Large Granular Lymphocytic Leukemia Accompanied with Pure Erythrocyte Aplastic Anemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):418-423

Department of Hematology, Foshan Hospitol Affiliated to Sun Yat-sen University, Foshan 536000, Guangdong Province, China.

Objective: To explore the clinical effects of oral small dose of cyclophosphamide (CTX) in the treatment of T-cell large granular lymphocytic leukemia (T-LGLL) accompanied with pure red cell aplasia (PRCA).

Methods: The clinical features, characteristics of laboratory examinations and the process of oral small dose of CTX treatment after the ineffective treatment of cyclosporine A combining with prednisone in 1 case of T-LGLL with PRCA were reported and discussed with related references.

Results: The elderly female patient had indolent process, mainly presenting with anemia and significant low hyperplasia of bone marrow erythrocyte cells. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.010DOI Listing

Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders.

J Vet Med Sci 2020 Jun 17;82(6):771-778. Epub 2020 Apr 17.

Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Non-neoplastic bone marrow disorders such as non-regenerative immune-mediated anemia, pure red cell aplasia, and myelodysplastic syndrome are major causes of non-regenerative anemia in dogs. However, there has been no study on the clinical and clinicopathological features of canine non-neoplastic bone marrow disorders in Japan. Hence, we first investigated the breed disposition of non-neoplastic bone marrow disorders that induce anemia as a retrospective study and found that Miniature Dachshund (MD) was a predisposed breed. Read More

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http://dx.doi.org/10.1292/jvms.19-0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324823PMC

Bone Marrow Findings of Immune-Mediated Pure Red Cell Aplasia Following Anti-Programmed Cell Death Receptor-1 Therapy: A Report of Two Cases and Review of Literature.

J Hematol 2019 Jun 30;8(2):71-78. Epub 2019 Jun 30.

Department of Hematopathology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.

Immune checkpoint inhibitors have recently emerged as important and effective advanced cancer treatment options. Programmed cell death receptor-1 (PD-1) antagonists such as pembrolizumab and nivolumab have been approved by the US Food and Drug Administration for treatment of many advanced cancers. As anti-PD-1 checkpoint inhibitor use has been increasing, previously unreported rare side effects emerge. Read More

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http://dx.doi.org/10.14740/jh507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153678PMC

A tale of autoimmunity: thymoma, thymectomy, and systemic lupus erythematosus.

Clin Rheumatol 2020 Jul 10;39(7):2227-2234. Epub 2020 Apr 10.

MedStar Health Internal Medicine Residency Program, Baltimore, MD, USA.

The thymus plays an integral role in immune system regulation, modulating the development, diversity, and selection of T lymphocytes, a critical feature for the prevention of T cell-mediated autoimmunity. Thymoma is a rare tumor of the thymus. Autoimmune diseases and paraneoplastic syndromes such as myasthenia gravis, pure red blood cell aplasia, and systemic lupus erythematosus, although relatively uncommon, have been described in association with thymomas. Read More

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http://dx.doi.org/10.1007/s10067-020-05061-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295737PMC

Pure Red Cell Aplasia and Antibody-Mediated Rejection: Double Trouble in 1 Kidney Transplant Recipient Solved by Intravenous Immunoglobulin Infusion: A Case Report.

Transplant Proc 2020 Apr 7. Epub 2020 Apr 7.

Department of Internal Medicine, Clinic of Nephrology, Hypertension and Internal Diseases of the University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Acquired pure red cell aplasia (PRCA) is characterized by severe normocytic (rarely macrocytic) and normochromic anemia, a low reticulocytes count in peripheral blood, and near absence of erythroid precursors in the bone marrow, with a normal level of erythropoietin. We describe a case of the kidney transplant recipient, diagnosed with PRCA induced with parvovirus B19 infection. Our case demonstrates that although this complication is rare, it should be considered in a differential diagnosis of anemia diagnostics in immunocompromised patients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.091DOI Listing

Pure red cell aplasia and amegakaryocytic thrombocytopenia in thymoma: The uncharted territory.

Clin Case Rep 2020 Apr 17;8(4):598-601. Epub 2020 Mar 17.

Azienda Ospedaliero Universitaria San Luigi Gonzaga Università di Torino Orbassano Italy.

Association between thymoma and pure red cell aplasia is already well-documented in literature whereas acquired amegakaryocytic thrombocytopenia is rarely reported. In this case, even with the addition of eltrombopag to standard immunosuppression, the cytopenias did not improve, probably due to the lack of surgical resection of the tumor. Read More

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http://dx.doi.org/10.1002/ccr3.2642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141733PMC

Acquired Pure Red Cell Aplasia Following Recombinant Erythropoietin (Darbepoetin-alfa) Therapy.

Indian J Nephrol 2020 Mar-Apr;30(2):113-116. Epub 2019 Sep 6.

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Acquired pure red cell aplasia (PRCA) following use of recombinant erythropoietin (rEPO) is distinctly rare and sporadically reported in the literature. We discuss a case of PRCA following the usage of rEPO (darbepoetin-α) during the management of anemia of chronic kidney disease in an elderly male subject with review of literature and a brief insight into proposed pathophysiologic mechanism, diagnosis, and management. Read More

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http://dx.doi.org/10.4103/ijn.IJN_129_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132853PMC
September 2019

Isoniazid Induced Pure Red Blood Cell Aplasia.

Cureus 2020 Feb 27;12(2):e7112. Epub 2020 Feb 27.

Hematology/Oncology, Southern Illinois University School of Medicine, Springfield, USA.

Pure red blood cell aplasia (PRCA) is one of the uncommon causes of anemia. Drug-induced PRCA is even more infrequent. Only a few drugs are implicated in PRCA. Read More

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http://dx.doi.org/10.7759/cureus.7112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101238PMC
February 2020

Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature.

Anemia 2020 15;2020:4812759. Epub 2020 Mar 15.

Division of Nephrology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Pure red cell aplasia (PRCA) is less common blood disorder; the causes and the treatments of PRCA are varied.

Methods: We conducted a retrospective study during January 2010-December 2017, to explore the etiologies and to evaluate the response and treatment burden in adult patients with PRCA.

Results: Of 32 PRCA patients, median age was 57 years (18-90 years). Read More

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http://dx.doi.org/10.1155/2020/4812759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102412PMC

Acquired Antibody-Mediated Pure Red Cell Aplasia Following Treatment With Darbepoetin.

Ann Acad Med Singapore 2020 Jan;49(1):46-48

Division of Nephrology, University Medicine Cluster, National University Health System, Singapore.

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January 2020

A case of dual-mechanism immune-related anaemia in a patient with metastatic melanoma treated with nivolumab and ipilimumab.

J Immunother Cancer 2020 03;8(1)

Medicine, The University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois, USA.

Background: The combination of the immune checkpoint inhibitors (ICIs) ipilimumab and nivolumab is a mainstay of treatment for selected patients with metastatic melanoma. This combination also results in more frequent immune-related adverse events (irAEs) than either ICI alone. These irAEs can be severe and their pathogenesis is poorly understood. Read More

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http://dx.doi.org/10.1136/jitc-2019-000380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069276PMC

Autoinflammation in addition to combined immunodeficiency: SLC29A3 gene defect.

Mol Immunol 2020 05 6;121:28-37. Epub 2020 Mar 6.

Department of Pediatric Immunology, Hacettepe University Medical Faculty, Ankara, Turkey.

Introduction: H Syndrome is an autosomal recessive (AR) disease caused by defects in SLCA29A3 gene. This gene encodes the equilibrative nucleoside transporter, the protein which is highly expressed in spleen, lymph node and bone marrow. Autoinflammation and autoimmunity accompanies H Syndrome (HS). Read More

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http://dx.doi.org/10.1016/j.molimm.2020.02.014DOI Listing

[Successful treatment of pure red cell aplasia complicated by multicentric Castleman disease with prednisolone].

Rinsho Ketsueki 2020 ;61(2):122-127

Department of Hematology, Yokohama City Minato Red Cross Hospital.

A 76-year-old man presented with shortness of breath and the laboratory tests suggested anemia and reticulocytopenia. CBC showed only anemia, and the bone marrow aspiration smear demonstrated absence of erythroid hematopoietic cells. Consequently, pure red cell aplasia (PRCA) was diagnosed. Read More

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http://dx.doi.org/10.11406/rinketsu.61.122DOI Listing

Clozapine-induced anemia: A case-report
.

Int J Clin Pharmacol Ther 2020 May;58(5):289-292

Clozapine, an atypical antipsychotic, can cause potentially life-threating side effects such as agranulocytosis. Our case presents a picture of severe anemia without any depression of the white cells or platelet lines. A 36-year-old man with treatment-resistant schizophrenia was admitted to the Psychiatric Unit for therapy assessment. Read More

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http://dx.doi.org/10.5414/CP203679DOI Listing

Management of thymoma-associated pure red cell aplasia: A novel use of blood substitute HBOC-201 in a Jehovah's Witness.

Clin Case Rep 2020 Feb 26;8(2):289-292. Epub 2019 Dec 26.

Department of Medicine Memorial Sloan Kettering Cancer Center New York New York.

Pure red cell aplasia (PRCA) is a rare paraneoplastic syndrome occasionally associated with thymomas. Here, we report on the first ever use of a bovine hemoglobin-based oxygen carrier, HBOC-201 (HbO2 Therapeutics LLC; Hemopure, Waltham, MA) for the supportive management of pure red cell aplasia in a Jehovah Witness patient. Read More

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http://dx.doi.org/10.1002/ccr3.2626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044386PMC
February 2020

Case Report: Pure Red Cell Aplasia due to Angioimmunoblastic T-Cell Lymphoma.

Case Rep Oncol 2020 Jan-Apr;13(1):76-78. Epub 2020 Feb 6.

Department of Internal Medicine, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal.

Pure red cell aplasia (PRCA) is a rare bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leukopenia and thrombocytopenia. It can be associated with various hematological disorders but exceedingly rarely with angioimmunoblastic T-cell lymphoma (AITL). We report the case of a 72-year-old woman with PRCA associated with AITL. Read More

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http://dx.doi.org/10.1159/000505533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036571PMC
February 2020

Pure Red Cell Aplasia with Del(20q) Sensitive for Immunosuppressive Treatment.

Case Rep Hematol 2020 20;2020:1262038. Epub 2020 Jan 20.

Section Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Pure red cell aplasia (PRCA) is a rare syndrome that only affects the erythroid lineage. It is defined by a normocytic, normochromic anemia with a marked reticulocytopenia and severe reduction or absence of erythroid precursors in the bone marrow. Treatment of primary, idiopathic PRCA is immunosuppressive therapy. Read More

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http://dx.doi.org/10.1155/2020/1262038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995481PMC
January 2020

Giant proerythroblasts in pure red cell aplasia due to parvovirus B19 infection in a patient with rheumatoid arthritis.

Am J Hematol 2020 08 5;95(8):990-991. Epub 2020 Mar 5.

Centre for Haematology, St Mary's Hospital campus of Imperial College Faculty of Medicine, St Mary's Hospital, London, UK.

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http://dx.doi.org/10.1002/ajh.25761DOI Listing

Successful sirolimus treatment of patients with pure red cell aplasia complicated with renal insufficiency.

Ann Hematol 2020 Apr 6;99(4):737-741. Epub 2020 Feb 6.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

For patients with pure red cell aplasia (PRCA), cyclosporine (CsA) is the first line therapy. Occasionally, some patients who suffer from renal insufficiency cannot tolerate CsA. To explore the efficacy and tolerance of sirolimus treatment for those patients, twelve PRCA patients with renal insufficiency from May 2014 to May 2018 in Peking Union Medical College Hospital were enrolled, treated with sirolimus, and followed up at the median time of 16 (10-50) months. Read More

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http://dx.doi.org/10.1007/s00277-020-03946-2DOI Listing
April 2020
2.634 Impact Factor

[How I diagnose and treat pure red cell aplasia].

Authors:
B Han

Zhonghua Xue Ye Xue Za Zhi 2020 Jan;41(1):5-9

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences, Beijing 100730, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357908PMC
January 2020

A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases.

J Thorac Cardiovasc Surg 2020 Jul 2;160(1):306-314.e14. Epub 2019 Dec 2.

Division of Thoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif. Electronic address:

Objective: Paraneoplastic syndromes associated with thymomas remain incompletely understood. The objective was to examine the association between surgically resected thymomas and paraneoplastic syndromes over the past half century.

Methods: A primary PubMed/MEDLINE search was used to identify published articles describing paraneoplastic syndromes associated with thymomas from 1960 to 2019. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.11.052DOI Listing

Acquired Pure Red Cell Aplasia.

Authors:
Sanjeev Kr

J Assoc Physicians India 2020 Jan;68(1):100

Meenakshi Mission Hospital and Research Centre.

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January 2020

Isoniazid Induced Acquired Pure Red Cell Aplasia: A Rare Case Report.

Authors:
Sanjana R Badami

J Assoc Physicians India 2020 Jan;68(1):99

SMS Hospital.

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January 2020

Immunosuppressive therapy for elderly-acquired pure red cell aplasia: cyclosporine A may be more effective.

Ann Hematol 2020 Mar 22;99(3):443-449. Epub 2020 Jan 22.

Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, 300# Guangzhou Road, Nanjing, 210029, Jiangsu Province, China.

This current study retrospectively analyzed the clinical characteristics of 69 adult patients with acquired pure red cell aplasia (PRCA) including 40 elderly and 29 non-elderly patients from September 2009 to June 2019. The remission induction therapy regimens included cyclosporine A (CsA), corticosteroids (CS), or other immunosuppressive agents. The overall response rate was 55% (22/40) in the elderly group compared with 75. Read More

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http://dx.doi.org/10.1007/s00277-020-03926-6DOI Listing

Coexistence of Pure Red Cell Aplasia and Autoimmune Haemolytic Anaemia Associated with Thymoma.

Acta Haematol 2020 Jan 21:1-5. Epub 2020 Jan 21.

Department of Haematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Thymoma is an uncommon neoplasia derived from the epithelial cells of the thymus, which leads to immune dysregulation and is associated with a series of autoimmune diseases. However, the concurrence of these disease entities is rare, and the exact mechanisms of these diseases are still unclear. We have admitted several cases who were diagnosed with thymoma, autoimmune haemolytic anaemia, and pure red cell aplasia. Read More

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http://dx.doi.org/10.1159/000503376DOI Listing
January 2020
0.994 Impact Factor