183 results match your criteria Pure B-Cell Disorders


Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study.

Blood 2018 Dec 21. Epub 2018 Dec 21.

Department of Nephrology, CHU Poitiers, Centre National de Reference Maladies Rares, Amylose AL et Autres Maladies a Depots d'Immunoglobulines Monoclonales, Poitiers, France;

Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of B-cell clonal disorders, defined by Congo-red negative deposits of monoclonal light chain (LCDD), heavy chain (HCDD), or both (LHCDD). MIDD is a systemic disorder with prominent renal involvement but little attention has been paid to the description of extra-renal manifestations. Moreover, mechanisms of pathogenic immunoglobulin deposition and factors associated with renal and patient survival are ill-defined. Read More

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http://dx.doi.org/10.1182/blood-2018-09-872028DOI Listing
December 2018
1 Read

B cell responses to apoptotic cells in MFG-E8-/- mice.

Authors:
YuFeng Peng

PLoS One 2018 4;13(10):e0205172. Epub 2018 Oct 4.

Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, United States of America.

Defective clearance of apoptotic cells in MFG-E8 deficient mice results in lupus-like disease in the mixed B6x129, but not pure B6 background. The lack of overt autoimmunity in MFG-E8-/- B6 mice suggests that accumulation of apoptotic cells is not sufficient to break central tolerance. However, the delayed clearance of apoptotic cells in the follicles of MFG-E8-/- B6 mice provides an excellent opportunity to investigate how B cells respond to excessive apoptotic cells in the periphery under relatively non-inflammatory conditions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205172PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171925PMC
October 2018
5 Reads

Clinical and laboratory features of seventy-eight UK patients with Good's syndrome (thymoma and hypogammaglobulinaemia).

Clin Exp Immunol 2019 Jan 21;195(1):132-138. Epub 2018 Oct 21.

Immunology, University of Manchester, Manchester University Hospitals NHS Trust, Manchester, UK.

Good's syndrome (thymoma and hypogammaglobulinaemia) is a rare secondary immunodeficiency disease, previously reported in the published literature as mainly individual cases or small case series. We use the national UK-Primary Immune Deficiency (UKPID) registry to identify a large cohort of patients in the UK with this PID to review its clinical course, natural history and prognosis. Clinical information, laboratory data, treatment and outcome were collated and analysed. Read More

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http://dx.doi.org/10.1111/cei.13216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300645PMC
January 2019
9 Reads

The devil is in the details: retention of recipient group A type 5 years after a successful allogeneic bone marrow transplant from a group O donor.

Immunohematology 2018 Jan;33(1):19-22

Michigan Medicine University of Michigan Ann Arbor, MI.

Conclusions: ABO-incompatible (ABOi) hematopoietic stem cell transplants (HSCTs) can present challenges in the blood bank. During transplantation, patients receive components that are ABO-compatible with both the donor graft and recipient; this practice can strain group O red blood cell (RBC) inventories.1 In addition, there are risks for acute hemolysis at the time of infusion and in the early post-transplant period. Read More

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January 2018
3 Reads

Myeloid cell leukemia-1 protein expression and myeloid cell leukemia-1 gene amplification in non small cell lung cancer.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):27-30

Department of Pathology, Albany Medical Center, Albany, New York, USA.

Background: Myeloid cell leukemia-1 (Mcl-1) is a member of the B-cell lymphoma 2 family known to play a significant role in the regulation of apoptosis. Mcl-1 expression has been studied in nonsmall cell lung cancer (NSCLC) cell lines but has not been previously evaluated as a prognostic factor in clinical samples.

Materials And Methods: Formalin-fixed, paraffin-embedded sections from 119 NSCLC, including 33 squamous cell carcinomas (SCC), 55 adenocarcinomas (AC), and 31 either pure adenocarcinoma in situ (AIS) or AC with lepidic features were immunostained by an automated method with rabbit polyclonal Mcl-1. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_731_16DOI Listing
November 2018

Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report.

Iran J Allergy Asthma Immunol 2018 Feb;17(1):85-93

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Good's syndrome, the adult onset hypogammaglobulinemia associated with thymoma has been explained about six decades ago. It generally presents with recurrent infections and several paraneoplastic syndromes including myasthenia gravis, pure red cell aplasia, connective tissue disorders, superior vena cava, Horner's syndrome, lichen planus and inflammatory bowel disease. Lack of B cell, dysfunction of T cell, CD4+ T cell lymphopenia, reversed CD4/CD8+ T cell ratio, autoantibodies against Th17 related cytokines have been respected as the pathogenesis of the immune dysregulation this syndrome. Read More

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February 2018
7 Reads

Rational management approach to pure red cell aplasia.

Haematologica 2018 02 7;103(2):221-230. Epub 2017 Dec 7.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, OH, USA

Pure red cell aplasia is an orphan disease, and as such lacks rationally established standard therapies. Most cases are idiopathic; a subset is antibody-mediated. There is overlap between idiopathic cases and those with T-cell large granular lymphocytic leukemia, hypogammaglobulinemia, and low-grade lymphomas. Read More

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http://dx.doi.org/10.3324/haematol.2017.175810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792266PMC
February 2018
9 Reads

Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A. nidulans.

Mycopathologia 2018 Apr 11;183(2):423-429. Epub 2017 Nov 11.

Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 15006, Prague 5, Czech Republic.

Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Read More

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http://dx.doi.org/10.1007/s11046-017-0223-8DOI Listing
April 2018
13 Reads

Digestive System Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.

Neuroendocrinology 2017 12;105(4):412-425. Epub 2017 Aug 12.

Department of Hepato-Gastroenterology and Digestive Oncology, Robert-Debré University Hospital, Reims, France.

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) are a heterogeneous subgroup of rare neoplasms that represent about a third of all poorly differentiated neuroendocrine carcinomas (PDNEC). MiNEN combine a neuroendocrine component, usually a PDNEC, and a non-neuroendocrine component, generally an adenocarcinoma, both accounting for at least 30% of the neoplasm. MiNEN are classified as high-, intermediate-, or low-grade malignancies depending on the metastatic potential of the tumour components. Read More

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http://dx.doi.org/10.1159/000475527DOI Listing
June 2018
18 Reads

Thymoma with immunodeficiency/Good syndrome associated with myasthenia gravis.

Rinsho Shinkeigaku 2017 05 27;57(5):208-213. Epub 2017 Apr 27.

Departments of Pathology, International University of Health and Welfare Hospital, Tochigi, Japan.

Good syndrome is a rare condition in which thymoma is associated with hypogammaglobulinemia; it is characterized by repeated respiratory or systemic infections caused by bacteria, viruses, and fungi, as well as with various autoimmune disorders such as pure red cell aplasia. A 65-year-old woman was admitted to our hospital with ptosis and abdominal muscle weakness. Based on the presence of anti-acetylcholine receptor (Ach-R) antibodies, she was diagnosed with myasthenia gravis (MG). Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-000984DOI Listing
May 2017
9 Reads

Prognostic significance of tumour infiltrating B lymphocytes in breast ductal carcinoma in situ.

Histopathology 2017 Aug 26;71(2):258-268. Epub 2017 May 26.

Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK.

Aims: Tumour-infiltrating lymphocytes (TILs) are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies have investigated the role of T lymphocytes in breast cancer, the role of B lymphocytes (TIL-Bs) in ductal carcinoma in situ (DCIS) remains uncertain. This study aimed to assess the role of TIL-Bs in DCIS. Read More

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http://dx.doi.org/10.1111/his.13217DOI Listing
August 2017
12 Reads

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report.

J Cardiothorac Surg 2017 Jan 25;12(1). Epub 2017 Jan 25.

Division of Chest Surgery, Toho University School of Medicine, Tokyo, Japan.

Background: Primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B cell lymphoma that is a type of non-Hodgkin lymphoma and a type of primary pulmonary malignant lymphoma. MALT lymphomas affecting the lung show various findings on chest computed tomography, which range from typical nodules or areas of consolidation to findings that are extremely rare in pulmonary MALT lymphomas, such as pure ground-glass opacities throughout the lung.

Case Presentation: A 35-year-old woman was found to have a few shadows with ground glass opacities on chest computed tomography (CT) in 2012. Read More

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http://dx.doi.org/10.1186/s13019-017-0565-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264446PMC
January 2017
17 Reads

Pure red cell aplasia.

Authors:
Robert T Means

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):51-56

Office of the Dean, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.

Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Read More

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http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
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http://dx.doi.org/10.1182/asheducation-2016.1.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142432PMC
December 2016
2 Reads

Pure red cell aplasia.

Authors:
Robert T Means

Blood 2016 11;128(21):2504-2509

Office of the Dean, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.

Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Read More

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http://dx.doi.org/10.1182/blood-2016-05-717140DOI Listing
November 2016
4 Reads

Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies.

J Vis Exp 2016 10 27(116). Epub 2016 Oct 27.

Department of Microbiology and Immunology, Western University;

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), thought to occur as a result of autoimmune responses targeting myelin. Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of CNS autoimmune disease, and is typically induced via immunization with short peptides representing immunodominant CD4 T cell epitopes of myelin proteins. However, B cells recognize unprocessed protein directly, and immunization with short peptide does not activate B cells that recognize the native protein. Read More

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http://dx.doi.org/10.3791/54727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226078PMC
October 2016
3 Reads

Multi-walled carbon nanotubes increase antibody-producing B cells in mice immunized with a tetravalent vaccine candidate for dengue virus.

J Nanobiotechnology 2016 Jul 27;14(1):61. Epub 2016 Jul 27.

Federal University of Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, Viçosa, MG, 36570-900, Brazil.

Background: In recent times, studies have demonstrated that carbon nanotubes are good candidates for use as vehicles for transfection of exogenous material into the cells. However, there are few studies evaluating the behavior of carbon nanotubes as DNA vectors and few of these studies have used multi-walled carbon nanotubes (MWCNTs) or carboxylated MWCNTs. Thus, this study aims to assess the MWCNTs' (carboxylated or not) efficiency in the increase in expression of the tetravalent vaccine candidate (TVC) plasmid vector for dengue virus in vitro using Vero cells, and in vivo, through the intramuscular route, to evaluate the immunological response profile. Read More

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http://dx.doi.org/10.1186/s12951-016-0196-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964006PMC
July 2016
20 Reads

Circulating miR-34a levels correlate with age-related hearing loss in mice and humans.

Exp Gerontol 2016 Apr 21;76:58-67. Epub 2016 Jan 21.

Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address:

Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circulating biomarkers in a wide range of diseases. Read More

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http://dx.doi.org/10.1016/j.exger.2016.01.009DOI Listing
April 2016
9 Reads

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice.

J Vis Exp 2015 11 1(105):e53319. Epub 2015 Nov 1.

Division of Immunobiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine;

Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical and immunological manifestations. Several spontaneous and inducible animal models mirror common components of human disease, including the bm12 transfer model. Upon transfer of bm12 splenocytes or purified CD4 T cells, C57BL/6 mice rapidly develop large frequencies of T follicular helper cells (Tfh), germinal center (GC) B cells, and plasma cells followed by high levels of circulating anti-nuclear antibodies. Read More

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http://dx.doi.org/10.3791/53319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692688PMC
November 2015
2 Reads

Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.

Hepatology 2015 Dec 16;62(6):1817-27. Epub 2015 Oct 16.

Department of Medicine and Biosystemic Science Graduate School of Medical Sciences, Kyushu University Fukuoka, Fukuoka, Japan.

Unlabelled: The hallmark of primary biliary cirrhosis (PBC) is the presence of autoreactive T- and B-cell responses that target biliary epithelial cells (BECs). Biliary cell cytotoxicity is dependent upon initiation of innate immune responses followed by chronic adaptive, as well as bystander, mechanisms. Critical to these mechanisms are interactions between natural killer (NK) cells and BECs. Read More

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http://dx.doi.org/10.1002/hep.28122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681684PMC
December 2015
5 Reads

[Dermatological manifestations of monoclonal gammopathies: contribution of cutaneous histopathology].

Ann Pathol 2015 Aug 15;35(4):281-93. Epub 2015 Jul 15.

Département de pathologie, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris (AP-HP), faculté de médecine, université Paris-Est-Créteil, 94010 Créteil cedex, France.

Skin manifestations associated with monoclonal gammapathy are common and can present with various clinical and pathological aspects. They can be the first events leading to the diagnosis of monoclonal gammapathy. They may be present either as specific lesions, including lymphoplasmacytic or pure plasma cell neoplastic infiltrates and monoclonal immunoglobulin deposits, or as non-specific dermatitis, such as leukocytoclastic vasculitis, neutrophilic dermatoses, mucinoses or xanthomatosis, giving little clues for the diagnosis of the underlying disease. Read More

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http://dx.doi.org/10.1016/j.annpat.2015.05.001DOI Listing
August 2015
6 Reads

Applying molecular epidemiology in pediatric leukemia.

J Investig Med 2016 Feb 11;64(2):355-60. Epub 2016 Jan 11.

Department of Pediatrics, Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.

Molecular epidemiology is the study of genetic and environmental risk for disease, with much effort centered on cancer. Childhood leukemia occurs in nearly a third of all patients newly diagnosed with pediatric cancer. only a small percentage of these new cases of childhood leukemia are associated with high penetrant hereditary cancer syndromes. Read More

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http://pdfs.journals.lww.com/jinvestigativemed/9000/00000/Ap
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http://healthcare.utah.edu/huntsmancancerinstitute/research/
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/JIM.0000000000000204DOI Listing
February 2016
8 Reads

Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.

Authors:
Semra Paydas

World J Gastroenterol 2015 Apr;21(13):3773-6

Semra Paydas, Department of Oncology, Cukurova University Faculty of Medicine 01330 Balcali, Turkey.

Diffuse large B cell lymphoma (DLBCL) of the stomach is a heterogenous disease. There are tumors without histological evidence of mucosa-associated lymphoid tissue (MALT) lymphoma, which are classified as pure or de novo DLBCL and those with evidence of MALT, which are classified as DLBCL (MALT). The association between Helicobacter pylori (H. Read More

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http://dx.doi.org/10.3748/wjg.v21.i13.3773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385524PMC
April 2015
4 Reads

Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications.

Clin Infect Dis 2015 Jul 31;61(2):e13-9. Epub 2015 Mar 31.

Département d'immunologie, Assistance Publique Hôpitaux de Paris (AP-HP) EA3518, Université Paris Diderot, Paris.

Background: Good syndrome (GS) is a rare condition in which thymoma is associated with hypogammaglobulinemia. It is characterized by increased susceptibility to bacterial, viral, and fungal infections, as well as autoimmunity. Most patients have no circulating B cells. Read More

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http://dx.doi.org/10.1093/cid/civ269DOI Listing
July 2015
51 Reads

Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm.

Am J Respir Crit Care Med 2015 Feb;191(4):402-9

1 Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua and Padua City Hospital, Padua, Italy.

Rationale: α1-Antitrypsin (AAT) is a potent protease inhibitor, deficiency of which is associated with the presence of emphysema. An imbalance of elastase and antielastase, along with innate inflammation in the lung, is believed to cause lung destruction in α1-antitrypsin deficiency (AATD). It is now apparent that AAT has important immune-regulatory roles that would be lost in AATD, yet adaptive immune responses in the lung have not been investigated in patients with AATD. Read More

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http://dx.doi.org/10.1164/rccm.201403-0529OCDOI Listing
February 2015
26 Reads

Helicobacter pylori-related diffuse large B-cell lymphoma of the stomach: a distinct entity with lower aggressiveness and higher chemosensitivity.

Blood Cancer J 2014 Jun 20;4:e220. Epub 2014 Jun 20.

1] Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan [2] Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan [3] Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan [4] Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan [5] Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.

We recently showed that Helicobacter pylori (HP)-positive gastric 'pure' diffuse large B-cell lymphoma (DLBCL) may respond to HP eradication therapy. However, whether these HP-related 'pure' DLBCL of the stomach may differ fundamentally from those unrelated to HP remains unclear. In this study, we compared the clinicopathologic features of these two groups of patients who had been uniformly treated by conventional chemotherapy. Read More

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http://dx.doi.org/10.1038/bcj.2014.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080211PMC
June 2014
1 Read

Secondary pure erythroid leukaemia in relapsed acute lymphoblastic leukaemia: lineage switch or chemotherapy effect?

BMJ Case Rep 2014 May 19;2014. Epub 2014 May 19.

Department of Medical Oncology, All India Institute of Medical Sciences (AIIMS), Delhi, India.

Pure erythroid leukaemia is a rare subtype of acute myeloid leukaemia (AML) and its occurrence at acute lymphoblastic leukaemia (ALL) relapse has not been reported earlier. A 39-year-old man received chemotherapy for Philadelphia-negative B cell ALL. Subsequently, he developed pure erythroid leukaemia with >80% immature erythroid precursors in bone marrow showing block positivity on periodic acid-Schiff stain, expressing CD71, CD34 but lacking CD235a. Read More

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http://dx.doi.org/10.1136/bcr-2013-201724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039854PMC
May 2014
5 Reads

Anterior panhypopituitarism in diffuse large B-cell stage IV lymphoma.

J Clin Neurosci 2014 Aug 16;21(8):1464-6. Epub 2014 Apr 16.

Division of Endocrinology, Department of Medicine, National University Hospital Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 10, Singapore 119228, Singapore.

The most common presentation of metastases to the pituitary gland in systemic lymphoma is diabetes insipidus resulting from infiltration of the infundibulum/posterior lobe. We describe a 69-year-old man with diffuse large B-cell stage IV lymphoma who presented with anterior pituitary hypofunction, without features of posterior pituitary involvement. He presented with a few months of postural dizziness and hypotension, weight loss, fever, strabismus of right eye and a superficial abdominal wall mass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868140006
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http://dx.doi.org/10.1016/j.jocn.2013.10.042DOI Listing
August 2014
2 Reads

Pure red cell aplasia complicating the course of long-standing mantle cell lymphoma.

Int J Hematol 2014 Jun 26;99(6):777-81. Epub 2014 Mar 26.

Department of Haematology, School of Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece.

Pure red cell aplasia (PRCA) is a rare cause of severe hypoplastic anemia characterized by profound depletion of erythroid precursors. Although PRCA may be associated with lymphoproliferative diseases, it has never been described in mantle cell lymphoma (MCL). We report what to our knowledge is the first case of a patient with indolent, non-nodal MCL complicated by PRCA. Read More

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http://link.springer.com/content/pdf/10.1007/s12185-014-1563
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http://link.springer.com/10.1007/s12185-014-1563-5
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http://dx.doi.org/10.1007/s12185-014-1563-5DOI Listing
June 2014
9 Reads

Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior.

Mod Pathol 2014 Aug 3;27(8):1116-25. Epub 2014 Jan 3.

Department of Pathology, National Taiwan University Hospital of Medicine, Taipei, Taiwan.

Primary gastric diffuse large B-cell lymphomas may or may not have a concurrent component of mucosa-associated lymphoid tissue lymphoma. Diffuse large B-cell lymphoma/mucosa-associated lymphoid tissue lymphomas are often associated with Helicobacter pylori (H. pylori) infection, suggesting that the large cells are transformed from mucosa-associated lymphoid tissue lymphomas. Read More

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http://dx.doi.org/10.1038/modpathol.2013.229DOI Listing
August 2014
5 Reads

Autoimmune cytopenias in chronic lymphocytic leukemia, facts and myths.

Mediterr J Hematol Infect Dis 2013 Nov 4;5(1):e2013068. Epub 2013 Nov 4.

Division of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

CLL has been defined as presence of more than 5000 small mature appearing monoclonal B lymphocytes with a specific immunophenotype in peripheral blood. It is a well-known fact that CLL is associated with autoimmune cytopenias. CLL cells are CD5(+) B lymphocytes, and usually are not the "guilty" cells which produce autoantibodies. Read More

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http://dx.doi.org/10.4084/MJHID.2013.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867225PMC
November 2013
7 Reads

Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation.

Nucleic Acids Res 2014 Jan 3;42(1):249-63. Epub 2013 Oct 3.

Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Avda. Gran Via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain, Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain, Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh, Center for Integrated Protein Science and Adolf-Butenandt Institute, Ludwig Maximilians University of Munich, 80336 Munich, Germany and CR-UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK.

Epstein-Barr virus (EBV) infects and transforms human primary B cells inducing indefinite proliferation. To investigate the potential participation of chromatin mechanisms during the EBV-mediated transformation of resting B cells we performed an analysis of global changes in histone modifications. We observed a remarkable decrease and redistribution of heterochromatin marks including H4K20me3, H3K27me3 and H3K9me3. Read More

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http://dx.doi.org/10.1093/nar/gkt886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874198PMC
January 2014
21 Reads

Pure anterograde memory deficit due to secondary lymphoma of the fornix.

Eur Neurol 2013 26;70(3-4):242. Epub 2013 Sep 26.

Neurocenter, Genolier Clinic, Genolier Swiss Medical Network, Genolier, Switzerland.

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http://dx.doi.org/10.1159/000351781DOI Listing
June 2014
2 Reads

Thyroid lymphoma: recent advances in diagnosis and optimal management strategies.

Oncologist 2013 23;18(9):994-1003. Epub 2013 Jul 23.

Department of Endocrine Surgery, St. Vincent's University Hospital, Dublin, Ireland.

Primary thyroid lymphoma is rare, composing approximately 5% of all thyroid malignancies and less than 3% of all extranodal lymphomas. It typically presents as a rapidly enlarging goiter with associated compressive symptoms. Thyroid ultrasound and fine needle aspiration cytology, using flow cytometry and immunohistochemistry, remain the main modalities used to confirm the presence of lymphoma. Read More

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http://dx.doi.org/10.1634/theoncologist.2013-0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780647PMC
September 2014
7 Reads

Autoimmune cytopenias in chronic lymphocytic leukemia.

Clin Dev Immunol 2013 16;2013:730131. Epub 2013 Apr 16.

Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy.

The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (AG) are, indeed, more rarely seen. Read More

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http://dx.doi.org/10.1155/2013/730131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652131PMC
December 2013
7 Reads

Clinicopathological prognostic indicators in 107 patients with diffuse large B-cell lymphoma transformed from follicular lymphoma.

Cancer Sci 2013 Jul 25;104(7):952-7. Epub 2013 Apr 25.

Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.

Follicular lymphoma (FL) frequently transforms into diffuse large B-cell lymphoma (DLBCL). To clarify the associated clinicopathological prognostic parameters, we examined the correlation of 11 histopathological parameters with progression-free survival (PFS) and overall survival (OS) in 107 consecutive patients who had DLBCL with pre-existing (asynchronous) or synchronous FL. The patients comprised 58 men and 49 women with a median age of 56 years. Read More

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http://doi.wiley.com/10.1111/cas.12158
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http://dx.doi.org/10.1111/cas.12158DOI Listing
July 2013
3 Reads

Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD components.

Am J Hematol 2013 Mar;88(3):219-24

Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

Some patients with systemic mastocytosis have concurrent hematological neoplasms, designated in the World Health Organization (WHO) classification as systemic mastocytosis with associated clonal hematological non-mast cell lineage disease (SM-AHNMD). In this study, we analyzed 29 patients with SM-AHNMD and compared them to 40 patients with pure SM. The AHNMDs were classified as chronic myelomonocytic leukemia (CMML) (n = 10), myelodysplastic syndrome (MDS) (n = 7), myeloproliferative neoplasms (n = 4), B-cell lymphoma/leukemia/plasma cell neoplasms (n = 7), and acute myeloid leukemia (n = 1). Read More

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http://dx.doi.org/10.1002/ajh.23380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188390PMC
March 2013
21 Reads

[Remission of lymphoma-associated pure red cell aplasia after successful chemotherapy for B-cell lymphoma].

Rinsho Ketsueki 2012 Dec;53(12):2021-4

Department of Hematology, Shinko Hospital, Japan.

A 49-year-old man was diagnosed with pure red cell aplasia (PRCA) based on low reticulocyte count (0.1%) and near absence of erythroblasts in the bone marrow (BM). While a small number of CD20-positive large abnormal cells was observed in the BM, Multiplex PCR confirmed B cell monoclonality. Read More

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December 2012
4 Reads

Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans.

Autoimmunity 2013 Mar 10;46(2):148-56. Epub 2013 Jan 10.

INSERM, Unité U768, Hôpital Necker Enfants-Malades, Paris, France.

Autoimmune manifestations are paradoxical and frequent complications of primary immunodeficiencies, including T and/or B cell defects. Among pure B cell defects, the Activation-induced cytidine Deaminase (AID)-deficiency, characterized by a complete lack of immunoglobulin class switch recombination and somatic hypermutation, is especially complicated by autoimmune disorders. We summarized in this review the different autoimmune and inflammatory manifestations present in 13 patients out of a cohort of 45 patients. Read More

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http://dx.doi.org/10.3109/08916934.2012.750299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077434PMC
March 2013
1 Read

A model system for assessing and comparing the ability of exon microarray and tag sequencing to detect genes specific for malignant B-cells.

BMC Genomics 2012 Nov 5;13:596. Epub 2012 Nov 5.

Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Sdr. Skovvej 15, 9000 Aalborg, Denmark.

Background: Malignant cells in tumours of B-cell origin account for 0.1% to 98% of the total cell content, depending on disease entity. Recently, gene expression profiles (GEPs) of B-cell lymphomas based on microarray technologies have contributed significantly to improved sub-classification and diagnostics. Read More

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http://dx.doi.org/10.1186/1471-2164-13-596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505742PMC
November 2012
3 Reads

Raloxifene inhibits growth of RT4 urothelial carcinoma cells via estrogen receptor-dependent induction of apoptosis and inhibition of proliferation.

Horm Cancer 2013 Feb 11;4(1):24-35. Epub 2012 Sep 11.

Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.

Bladder cancer is the fifth most common type of cancer in the USA, with over 70,000 new cases diagnosed each year. Treatment often involves invasive surgical therapies, as chemotherapy alone is often ineffective and associated with high recurrence rates. Identification of estrogen receptor-β (ERβ) in up to 75 % of urinary tumors raises the question of whether this receptor could be targeted to effectively treat bladder cancer. Read More

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http://dx.doi.org/10.1007/s12672-012-0123-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541450PMC
February 2013
14 Reads

A case of Good syndrome with pulmonary lesions similar to diffuse panbronchiolitis.

Intern Med 2012 29;51(9):1087-91. Epub 2012 Apr 29.

Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan.

We herein present a case of Good syndrome complicated by diffuse pulmonary lesions similar to diffuse panbronchiolitis (DPB). A 45-year-old Japanese man was referred to our department due to recurrent lower respiratory tract infections that had started and ameliorated nine months after thymectomy for pure red cell aplasia and myasthenia gravis. Diffuse centrilobular opacities on chest computed tomography and positivity for HLA-B54 were consistent with DPB. Read More

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March 2013
9 Reads

Peripheral neuropathies in Sjögren's syndrome: a critical update on clinical features and pathogenetic mechanisms.

J Autoimmun 2012 Aug 6;39(1-2):27-33. Epub 2012 Feb 6.

Neuroimmunology Unit, Department of Pathophysiology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Athens 11527, Greece.

Sjögren's syndrome is a systemic autoimmune disease that, apart from exocrine glands, may affect every organ or system. Involvement of different sections of the peripheral nervous system results in a wide spectrum of neuropathic manifestations. Based on distinct clinical, electrophysiological and histological criteria, the types of neuropathies seen in Sjögren's syndrome include: a) pure sensory which presents with distal symmetric sensory loss due to axonal degeneration of sensory fibers; sensory ataxia due to loss of proprioceptive large fibers (ganglionopathy); or with painful dysethesias (small fiber sensory neuropathy) due to degeneration of cutaneous axons. Read More

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http://dx.doi.org/10.1016/j.jaut.2012.01.003DOI Listing
August 2012
1 Read

Pathogenesis and treatment of leukemia: an Asian perspective.

Authors:
Yok-Lam Kwong

Expert Opin Ther Targets 2012 Mar 7;16 Suppl 1:S37-43. Epub 2012 Feb 7.

Queen Mary Hospital, Department of Medicine, Professorial Block, Pokfulam Road, Hong Kong, China.

Introduction: Leukemias occur worldwide, but there are important geographic differences in incidences.

Areas Covered: Three leukemias with special Asian perspectives, acute promyelocytic leukemia (APL), T-cell large granular lymphocyte (T-LGL) leukemia and NK-cell leukemia.

Expert Opinion: In APL, China has made contributions in discovering the efficacy of all-trans retinoic acid (ATRA) and arsenic trioxide. Read More

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http://dx.doi.org/10.1517/14728222.2011.621418DOI Listing
March 2012
1 Read

Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone.

Mol Immunol 2012 Feb 14;50(1-2):49-56. Epub 2012 Jan 14.

Division of Immunity and Inflammation, Department of Medicine, Imperial College London, W12 0NN, UK.

Fcgamma receptor 2b (Fcgr2b) is the only inhibitory Fcgamma receptor in both humans and mice, and is implicated in both antibody production and effector responses to antibody complexes. Reduced function of Fcgr2b has previously been associated with anti-glomerular basement membrane antibody (anti-GBM) disease in mice. However, the mice used had 129 genetic elements flanking the deleted Fcgr2b gene, which are known to increase susceptibility to autoimmunity. Read More

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http://dx.doi.org/10.1016/j.molimm.2011.12.007DOI Listing
February 2012
4 Reads

PET imaging in a longitudinal non-Hodgkin's lymphoma study: association with tumor volume.

Acta Radiol 2011 Nov 23;52(9):995-1002. Epub 2011 Sep 23.

Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland.

Background: Computed tomography (CT) is generally used in the evaluation of the treatment response of non-Hodgkin's lymphoma (NHL) patients. Instead of morphological images, positron emission tomography (PET) shows metabolic information that is connected to tumor activity, cell proliferation rate, and, thus, prognosis.

Purpose: To determine the prognostic value of PET for tumor volume reduction measured by CT and magnetic resonance imaging (MRI) along with clinical characteristics in NHL patients. Read More

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http://dx.doi.org/10.1258/ar.2011.110099DOI Listing
November 2011
4 Reads

Clinical and pathological features of testicular diffuse large B-cell lymphoma: a heterogeneous disease.

Leuk Lymphoma 2012 Feb 19;53(2):242-6. Epub 2011 Sep 19.

Department of Oncology, Waikato DHB, Hamilton, New Zealand.

Most testicular lymphomas are of diffuse large B-cell (DLBCL) type with an outcome inferior to nodal DLBCL. Within an apparently homogeneous group of testicular DLBCLs, small cell components, plasmacytoid differentiation and lymphoepithelial lesions (LELs), features of extranodal marginal zone lymphoma (eMZL), can be identified. The aim of this study was to define the histological features of testicular DLBCL and correlate this with their clinical behavior and outcome. Read More

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http://www.tandfonline.com/doi/full/10.3109/10428194.2011.60
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http://dx.doi.org/10.3109/10428194.2011.607528DOI Listing
February 2012
6 Reads

Rituximab-cyclophosphamide-dexamethasone combination in management of autoimmune cytopenias associated with chronic lymphocytic leukemia.

Leuk Lymphoma 2011 Jul;52(7):1401-3

Hospices Civils de Lyon, Department of Hematology, Lyon-Sud University Hospital, Pierre-Bénite, France.

We report our experience on rituximab-cyclophosphamide-dexamethasone (RCD) combination therapy for the treatment of autoimmune disorders in 48 patients with chronic lymphocytic leukemia (CLL). The diagnosis of autoimmune disease (AID) was autoimmune hemolytic anemia (AIHA) in 26 (54%), autoimmune thrombocytopenic purpura (AITP) in nine (18.8%), Evans syndrome in eight (16. Read More

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http://dx.doi.org/10.3109/10428194.2011.591005DOI Listing
July 2011
5 Reads

Functional characterization of the P1059L mutation in the inositol 1,4,5-trisphosphate receptor type 1 identified in a Japanese SCA15 family.

Biochem Biophys Res Commun 2011 Jul 13;410(4):754-8. Epub 2011 Jun 13.

Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama 351-0198, Japan.

Spinocerebellar ataxia type 15 (SCA15) is a group of human neurodegenerative disorders characterized by a slowly progressing pure cerebellar ataxia. The inositol 1,4,5-trisphosphate (IP(3)) receptor type 1 (IP(3)R1) is an intracellular IP(3)-induced Ca(2+) release channel that was recently identified as a causative gene for SCA15. In most case studies, a heterozygous deletion of the IP(3)R1 gene was identified. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1101001
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http://dx.doi.org/10.1016/j.bbrc.2011.06.043DOI Listing
July 2011
4 Reads

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL.

Leukemia 2011 Sep 24;25(9):1452-8. Epub 2011 May 24.

Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department for Hematology, Federal Hospital of Salzburg and Paracelsus Medical Private University, Salzburg, Austria.

Chronic lymphocytic leukemia (CLL) cells require complex microenvironmental and immunologic interactions to survive and proliferate. Such interactions might be best recreated in animal models; however, this needs extensive verification. We therefore investigated the composition of the T-cell compartment in the Eμ-TCL1 transgenic mouse, currently the most widely used murine model for CLL. Read More

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http://dx.doi.org/10.1038/leu.2011.111DOI Listing
September 2011
2 Reads