196 results match your criteria Pure B-Cell Disorders


Intrasinusoidal HHV8-EBV-Positive Large B-Cell Lymphoma With Features of Germinotropic Lymphoproliferative Disorder.

Int J Surg Pathol 2020 May 18:1066896920921238. Epub 2020 May 18.

Hospital Clinico Universitario of Valencia, University of Valencia, Valencia, Spain.

Germinotropic lymphoproliferative disorder (GLPD) is a poorly characterized lymphoproliferative entity, recently included in the World Health Organization classification of hematolymphoid neoplasms. The histological pattern of this disease comprises monotypic plasmablasts that involve the germinal centers of the lymphoid follicles (germinotrophism), forming confluent aggregates positive for both human herpes virus type 8 (HHV8) and Epstein-Barr virus. Currently, after 17 years of its first description, only 18 cases have been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1066896920921238DOI Listing

Antioxidant, Antiproliferative and Apoptosis-Inducing Efficacy of Fractions from L. Leaves.

Antioxidants (Basel) 2020 Feb 20;9(2). Epub 2020 Feb 20.

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.

Cassia fistula L. is a highly admirable traditional medicinal plant used for the treatment of various diseases and disorders. The present study was performed to divulge the antioxidant, antiproliferative, and apoptosis-inducing efficacy of fractions from leaves. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antiox9020173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070616PMC
February 2020

The many (sur)faces of B cells.

Biomed J 2019 08 3;42(4):201-206. Epub 2019 Oct 3.

University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Ole Maaløes Vej 5, 2200 Copenhagen Denmark. Electronic address:

This issue of the Biomedical Journal is dedicated to the latest findings concerning the complex development and functions of B lymphocytes, including their origins during embryogenesis, their meticulous control by the CD22 receptor and different types of T cells, as well as the immunosuppressive abilities of certain B cell subsets. Furthermore, we learn about the complicated genetic background of a rare cardiac disease, the surgical outcomes of pure conus medullaris syndrome and occurrences of tuberculous spondylitis after percutaneous vertebroplasty. Finally, we discover that brain waves could very well be used for biometric authentication and that diffusion imaging displays good reproducibility through a spectrum of spatial resolutions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818141PMC

Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma.

Am J Clin Pathol 2020 01;153(2):156-164

Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.

Objectives: To assess the prevalence of Hashimoto thyroiditis (HT) in primary thyroid lymphoma (PTL) and whether it differs between mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBCL).

Methods: Electronic databases were searched for studies assessing HT prevalence in PTL, based on antithyroid antibodies, clinical history, or pathology. Pooled prevalence of HT and its association with histotype (MALT or DLBCL) were calculated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqz145DOI Listing
January 2020
1 Read

Traceless aptamer-mediated isolation of CD8 T cells for chimeric antigen receptor T-cell therapy.

Nat Biomed Eng 2019 10 17;3(10):783-795. Epub 2019 Jun 17.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

Chimeric antigen receptor T-cell therapies using defined product compositions require high-purity T-cell isolation systems that, unlike immunomagnetic positive enrichment, are inexpensive and leave no trace on the final cell product. Here, we show that DNA aptamers (generated with a modified cell-SELEX procedure to display low-nanomolar affinity for the T-cell marker CD8) enable the traceless isolation of pure CD8 T cells at low cost and high yield. Captured CD8 T cells are released label-free by complementary oligonucleotides that undergo toehold-mediated strand displacement with the aptamer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41551-019-0411-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783348PMC
October 2019
7 Reads

Establishment and Expression of Cytokines in a -Infected Bovine B Cell Line.

Genes (Basel) 2019 04 30;10(5). Epub 2019 Apr 30.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, China.

This study aimed to establish a pure single-cell -infected B cell line for the assessment of cytokine production in transformed and lipopolysaccharide (LPS)-stimulated cells. Several studies have aimed to identify cell surface markers in -transformed cells; however, no information on cytokine production in these cells is available. To investigate the potential of the transformed cells to produce cytokines and their potential responses to antigen-stimulation, we purified mature B cells (CD21) from the whole blood of cattle experimentally infected with the Kashi strain by magnetic separation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10050329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562936PMC
April 2019
10 Reads

Cutaneous localization of plasmablastic multiple myeloma with heterotopic expression of CD3 and CD4: Skin involvement revealing systemic disease.

J Cutan Pathol 2019 Aug 10;46(8):619-622. Epub 2019 May 10.

Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.

Plasmablastic multiple myeloma is an uncommon morphological variant of multiple myeloma with aggressive clinical course and poor outcome. Its differential diagnosis includes plasmablastic lymphoma, a variant of diffuse large B-cell lymphoma with frequent extranodal presentation, which usually affects immunosuppressed patients and is virtually indistinguishable from plasmablastic multiple myeloma on the basis of histology solely. Differential diagnosis relies on close clinical-pathological correlation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cup.13486DOI Listing
August 2019
12 Reads

Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma.

Eur J Haematol 2019 Jul 30;103(1):35-42. Epub 2019 May 30.

Service de médecine interne, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est, Créteil, France.

Objective: Angioimmunoblastic T-cell lymphoma (AITL) is frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear.

Method: Angioimmunoblastic T-cell lymphoma patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1/5 ratio). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejh.13239DOI Listing
July 2019
19 Reads

The prevalence and prognostic significance of autoimmune cytopenias in a cohort of Egyptian patients with chronic lymphocytic leukemia.

Hematol Oncol Stem Cell Ther 2019 Jun 20;12(2):97-104. Epub 2019 Feb 20.

The Hematology Unit, Oncology Center, Mansoura University, Mansoura, Egypt. Electronic address:

Objective/background: The impact of autoimmune cytopenias (AICs) on the chronic lymphocytic leukemia (CLL) clinical course and its prognostic significance remain a matter of controversial debate. This could be due to exclusion of patients with cytopenia from most clinical trials for this particular complication and the lack of standard diagnostic criteria and treatment approaches. We herein evaluate the prevalence and the prognostic significance of AICs among patients with CLL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hemonc.2019.01.004DOI Listing
June 2019
8 Reads

Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study.

Blood 2019 02 21;133(6):576-587. Epub 2018 Dec 21.

Department of Nephrology, CHU Poitiers, Poitiers, France.

Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of B-cell clonal disorders, defined by Congo red negative-deposits of monoclonal light chain (LCDD), heavy chain (HCDD), or both (LHCDD). MIDD is a systemic disorder with prominent renal involvement, but little attention has been paid to the description of extrarenal manifestations. Moreover, mechanisms of pathogenic immunoglobulin deposition and factors associated with renal and patient survival are ill defined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2018-09-872028DOI Listing
February 2019
9 Reads

Bidirectional effects of IL-10 regulatory B cells in Ldlr mice.

Atherosclerosis 2019 01 9;280:118-125. Epub 2018 Nov 9.

Division of BioTherapeutics, LACDR, Leiden University, Leiden, the Netherlands.

Background And Aims: Limiting the pro-inflammatory immune response is critical for the treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response through interleukin-10 (IL-10). Current data regarding Bregs and atherosclerosis is scarce and conflicting. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00219150183147
Publisher Site
http://dx.doi.org/10.1016/j.atherosclerosis.2018.11.019DOI Listing
January 2019
37 Reads

B cell responses to apoptotic cells in MFG-E8-/- mice.

Authors:
YuFeng Peng

PLoS One 2018 4;13(10):e0205172. Epub 2018 Oct 4.

Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, United States of America.

Defective clearance of apoptotic cells in MFG-E8 deficient mice results in lupus-like disease in the mixed B6x129, but not pure B6 background. The lack of overt autoimmunity in MFG-E8-/- B6 mice suggests that accumulation of apoptotic cells is not sufficient to break central tolerance. However, the delayed clearance of apoptotic cells in the follicles of MFG-E8-/- B6 mice provides an excellent opportunity to investigate how B cells respond to excessive apoptotic cells in the periphery under relatively non-inflammatory conditions. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205172PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171925PMC
April 2019
36 Reads

Clinical and laboratory features of seventy-eight UK patients with Good's syndrome (thymoma and hypogammaglobulinaemia).

Clin Exp Immunol 2019 01 21;195(1):132-138. Epub 2018 Oct 21.

Immunology, University of Manchester, Manchester University Hospitals NHS Trust, Manchester, UK.

Good's syndrome (thymoma and hypogammaglobulinaemia) is a rare secondary immunodeficiency disease, previously reported in the published literature as mainly individual cases or small case series. We use the national UK-Primary Immune Deficiency (UKPID) registry to identify a large cohort of patients in the UK with this PID to review its clinical course, natural history and prognosis. Clinical information, laboratory data, treatment and outcome were collated and analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cei.13216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300645PMC
January 2019
50 Reads

Autoimmune cytopenias in patients with chronic lymphocytic leukaemia treated with ibrutinib in routine clinical practice at an academic medical centre.

Br J Haematol 2018 11 16;183(3):421-427. Epub 2018 Aug 16.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

The effects of ibrutinib on the natural history of autoimmune cytopenias (AIC) among chronic lymphocytic leukaemia (CLL) patients treated in routine clinical practice require further investigation. Using the Mayo Clinical CLL Database, 193 CLL patients treated with ibrutinib between November 2013 and January 2017 outside the context of a clinical trial were identified; complete review of their medical records was performed for details of past history of AIC and treatment-emergent AIC. We identified 29/193 (15%) patients with history of AIC prior to ibrutinib start. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.15545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234062PMC
November 2018
20 Reads
1 Citation
4.711 Impact Factor

Autoimmune cytopenias in chronic lymphocytic leukemia: a concise review and treatment recommendations.

Expert Rev Hematol 2018 08 14;11(8):613-624. Epub 2018 Jul 14.

a Department of Hematology and Lymphoma and Myeloma Center (LYMMCARE) , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

Introduction: Chronic lymphocytic leukemia (CLL) is frequently complicated by cytopenias, either due to bone marrow infiltration or autoimmunity, resulting in autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia (PRCA), or autoimmune neutropenia (AIN). Morbidity due to autoimmune cytopenias (AIC) can be substantial; in addition, infection risk increases and pre-existing infections might deteriorate due to immunosuppressive medication. In the aging population, CLL occurs more frequently and AIC related to CLL represent a growing clinical challenge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17474086.2018.1489720DOI Listing
August 2018
49 Reads

The devil is in the details: retention of recipient group A type 5 years after a successful allogeneic bone marrow transplant from a group O donor.

Immunohematology 2018 Jan;33(1):19-22

Michigan Medicine University of Michigan Ann Arbor, MI.

Conclusions: ABO-incompatible (ABOi) hematopoietic stem cell transplants (HSCTs) can present challenges in the blood bank. During transplantation, patients receive components that are ABO-compatible with both the donor graft and recipient; this practice can strain group O red blood cell (RBC) inventories.1 In addition, there are risks for acute hemolysis at the time of infusion and in the early post-transplant period. Read More

View Article

Download full-text PDF

Source
January 2018
12 Reads

Development of an unbiased, semi-automated approach for classifying plasma cell immunophenotype following multicolor flow cytometry of bone marrow aspirates.

Cytometry B Clin Cytom 2018 09 6;94(5):602-610. Epub 2018 Apr 6.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: Despite increased usage of multiparameter flow cytometry (MFC) to assess diagnosis, prognosis, and therapeutic efficacy (minimal residual disease, MRD) in plasma cell neoplasms (PCNs), standardization of methodology and data analysis is suboptimal. We investigated the utility of using the mean and median fluorescence intensities (FI) obtained from MFC to objectively describe parameters that distinguish plasma cell (PC) phenotypes.

Methods: In this retrospective study, flow cytometry results from bone marrow aspirate specimens from 570 patients referred to the Myeloma Institute at UAMS were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.b.21635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150794PMC
September 2018
4 Reads

Myeloid cell leukemia-1 protein expression and myeloid cell leukemia-1 gene amplification in non small cell lung cancer.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):27-30

Department of Pathology, Albany Medical Center, Albany, New York, USA.

Background: Myeloid cell leukemia-1 (Mcl-1) is a member of the B-cell lymphoma 2 family known to play a significant role in the regulation of apoptosis. Mcl-1 expression has been studied in nonsmall cell lung cancer (NSCLC) cell lines but has not been previously evaluated as a prognostic factor in clinical samples.

Materials And Methods: Formalin-fixed, paraffin-embedded sections from 119 NSCLC, including 33 squamous cell carcinomas (SCC), 55 adenocarcinomas (AC), and 31 either pure adenocarcinoma in situ (AIS) or AC with lepidic features were immunostained by an automated method with rabbit polyclonal Mcl-1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_731_16DOI Listing
November 2018
9 Reads

Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report.

Iran J Allergy Asthma Immunol 2018 Feb;17(1):85-93

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Good's syndrome, the adult onset hypogammaglobulinemia associated with thymoma has been explained about six decades ago. It generally presents with recurrent infections and several paraneoplastic syndromes including myasthenia gravis, pure red cell aplasia, connective tissue disorders, superior vena cava, Horner's syndrome, lichen planus and inflammatory bowel disease. Lack of B cell, dysfunction of T cell, CD4+ T cell lymphopenia, reversed CD4/CD8+ T cell ratio, autoantibodies against Th17 related cytokines have been respected as the pathogenesis of the immune dysregulation this syndrome. Read More

View Article

Download full-text PDF

Source
February 2018
35 Reads

Rational management approach to pure red cell aplasia.

Haematologica 2018 02 7;103(2):221-230. Epub 2017 Dec 7.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, OH, USA

Pure red cell aplasia is an orphan disease, and as such lacks rationally established standard therapies. Most cases are idiopathic; a subset is antibody-mediated. There is overlap between idiopathic cases and those with T-cell large granular lymphocytic leukemia, hypogammaglobulinemia, and low-grade lymphomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2017.175810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792266PMC
February 2018
24 Reads

Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A. nidulans.

Mycopathologia 2018 Apr 11;183(2):423-429. Epub 2017 Nov 11.

Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 15006, Prague 5, Czech Republic.

Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11046-017-0223-8DOI Listing
April 2018
24 Reads

Digestive System Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.

Neuroendocrinology 2017 12;105(4):412-425. Epub 2017 Aug 12.

Department of Hepato-Gastroenterology and Digestive Oncology, Robert-Debré University Hospital, Reims, France.

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) are a heterogeneous subgroup of rare neoplasms that represent about a third of all poorly differentiated neuroendocrine carcinomas (PDNEC). MiNEN combine a neuroendocrine component, usually a PDNEC, and a non-neuroendocrine component, generally an adenocarcinoma, both accounting for at least 30% of the neoplasm. MiNEN are classified as high-, intermediate-, or low-grade malignancies depending on the metastatic potential of the tumour components. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000475527DOI Listing
June 2018
51 Reads

Thymoma with immunodeficiency/Good syndrome associated with myasthenia gravis.

Rinsho Shinkeigaku 2017 05 27;57(5):208-213. Epub 2017 Apr 27.

Departments of Pathology, International University of Health and Welfare Hospital, Tochigi, Japan.

Good syndrome is a rare condition in which thymoma is associated with hypogammaglobulinemia; it is characterized by repeated respiratory or systemic infections caused by bacteria, viruses, and fungi, as well as with various autoimmune disorders such as pure red cell aplasia. A 65-year-old woman was admitted to our hospital with ptosis and abdominal muscle weakness. Based on the presence of anti-acetylcholine receptor (Ach-R) antibodies, she was diagnosed with myasthenia gravis (MG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5692/clinicalneurol.cn-000984DOI Listing
May 2017
35 Reads

Prognostic significance of tumour infiltrating B lymphocytes in breast ductal carcinoma in situ.

Histopathology 2017 Aug 26;71(2):258-268. Epub 2017 May 26.

Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK.

Aims: Tumour-infiltrating lymphocytes (TILs) are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies have investigated the role of T lymphocytes in breast cancer, the role of B lymphocytes (TIL-Bs) in ductal carcinoma in situ (DCIS) remains uncertain. This study aimed to assess the role of TIL-Bs in DCIS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/his.13217DOI Listing
August 2017
51 Reads

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report.

J Cardiothorac Surg 2017 Jan 25;12(1). Epub 2017 Jan 25.

Division of Chest Surgery, Toho University School of Medicine, Tokyo, Japan.

Background: Primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B cell lymphoma that is a type of non-Hodgkin lymphoma and a type of primary pulmonary malignant lymphoma. MALT lymphomas affecting the lung show various findings on chest computed tomography, which range from typical nodules or areas of consolidation to findings that are extremely rare in pulmonary MALT lymphomas, such as pure ground-glass opacities throughout the lung.

Case Presentation: A 35-year-old woman was found to have a few shadows with ground glass opacities on chest computed tomography (CT) in 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13019-017-0565-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264446PMC
January 2017
53 Reads

Pure red cell aplasia.

Authors:
Robert T Means

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):51-56

Office of the Dean, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.

Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Read More

View Article

Download full-text PDF

Source
http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
Publisher Site
http://dx.doi.org/10.1182/asheducation-2016.1.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142432PMC
December 2016
12 Reads

Pure red cell aplasia.

Authors:
Robert T Means

Blood 2016 11;128(21):2504-2509

Office of the Dean, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.

Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-05-717140DOI Listing
November 2016
11 Reads

Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies.

J Vis Exp 2016 10 27(116). Epub 2016 Oct 27.

Department of Microbiology and Immunology, Western University;

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), thought to occur as a result of autoimmune responses targeting myelin. Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of CNS autoimmune disease, and is typically induced via immunization with short peptides representing immunodominant CD4 T cell epitopes of myelin proteins. However, B cells recognize unprocessed protein directly, and immunization with short peptide does not activate B cells that recognize the native protein. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/54727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226078PMC
October 2016
15 Reads

Multi-walled carbon nanotubes increase antibody-producing B cells in mice immunized with a tetravalent vaccine candidate for dengue virus.

J Nanobiotechnology 2016 Jul 27;14(1):61. Epub 2016 Jul 27.

Federal University of Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, Viçosa, MG, 36570-900, Brazil.

Background: In recent times, studies have demonstrated that carbon nanotubes are good candidates for use as vehicles for transfection of exogenous material into the cells. However, there are few studies evaluating the behavior of carbon nanotubes as DNA vectors and few of these studies have used multi-walled carbon nanotubes (MWCNTs) or carboxylated MWCNTs. Thus, this study aims to assess the MWCNTs' (carboxylated or not) efficiency in the increase in expression of the tetravalent vaccine candidate (TVC) plasmid vector for dengue virus in vitro using Vero cells, and in vivo, through the intramuscular route, to evaluate the immunological response profile. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12951-016-0196-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964006PMC
July 2016
55 Reads

Circulating miR-34a levels correlate with age-related hearing loss in mice and humans.

Exp Gerontol 2016 Apr 21;76:58-67. Epub 2016 Jan 21.

Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address:

Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circulating biomarkers in a wide range of diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2016.01.009DOI Listing
April 2016
40 Reads

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice.

J Vis Exp 2015 11 1(105):e53319. Epub 2015 Nov 1.

Division of Immunobiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine;

Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical and immunological manifestations. Several spontaneous and inducible animal models mirror common components of human disease, including the bm12 transfer model. Upon transfer of bm12 splenocytes or purified CD4 T cells, C57BL/6 mice rapidly develop large frequencies of T follicular helper cells (Tfh), germinal center (GC) B cells, and plasma cells followed by high levels of circulating anti-nuclear antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/53319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692688PMC
November 2015
13 Reads

Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.

Hepatology 2015 Dec 16;62(6):1817-27. Epub 2015 Oct 16.

Department of Medicine and Biosystemic Science Graduate School of Medical Sciences, Kyushu University Fukuoka, Fukuoka, Japan.

Unlabelled: The hallmark of primary biliary cirrhosis (PBC) is the presence of autoreactive T- and B-cell responses that target biliary epithelial cells (BECs). Biliary cell cytotoxicity is dependent upon initiation of innate immune responses followed by chronic adaptive, as well as bystander, mechanisms. Critical to these mechanisms are interactions between natural killer (NK) cells and BECs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.28122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681684PMC
December 2015
32 Reads

[Dermatological manifestations of monoclonal gammopathies: contribution of cutaneous histopathology].

Ann Pathol 2015 Aug 15;35(4):281-93. Epub 2015 Jul 15.

Département de pathologie, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris (AP-HP), faculté de médecine, université Paris-Est-Créteil, 94010 Créteil cedex, France.

Skin manifestations associated with monoclonal gammapathy are common and can present with various clinical and pathological aspects. They can be the first events leading to the diagnosis of monoclonal gammapathy. They may be present either as specific lesions, including lymphoplasmacytic or pure plasma cell neoplastic infiltrates and monoclonal immunoglobulin deposits, or as non-specific dermatitis, such as leukocytoclastic vasculitis, neutrophilic dermatoses, mucinoses or xanthomatosis, giving little clues for the diagnosis of the underlying disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annpat.2015.05.001DOI Listing
August 2015
34 Reads

Applying molecular epidemiology in pediatric leukemia.

J Investig Med 2016 Feb 11;64(2):355-60. Epub 2016 Jan 11.

Department of Pediatrics, Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.

Molecular epidemiology is the study of genetic and environmental risk for disease, with much effort centered on cancer. Childhood leukemia occurs in nearly a third of all patients newly diagnosed with pediatric cancer. only a small percentage of these new cases of childhood leukemia are associated with high penetrant hereditary cancer syndromes. Read More

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/jinvestigativemed/9000/00000/Ap
Web Search
http://healthcare.utah.edu/huntsmancancerinstitute/research/
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/JIM.0000000000000204DOI Listing
February 2016
18 Reads

Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.

Authors:
Semra Paydas

World J Gastroenterol 2015 Apr;21(13):3773-6

Semra Paydas, Department of Oncology, Cukurova University Faculty of Medicine 01330 Balcali, Turkey.

Diffuse large B cell lymphoma (DLBCL) of the stomach is a heterogenous disease. There are tumors without histological evidence of mucosa-associated lymphoid tissue (MALT) lymphoma, which are classified as pure or de novo DLBCL and those with evidence of MALT, which are classified as DLBCL (MALT). The association between Helicobacter pylori (H. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v21.i13.3773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385524PMC
April 2015
32 Reads

Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications.

Clin Infect Dis 2015 Jul 31;61(2):e13-9. Epub 2015 Mar 31.

Département d'immunologie, Assistance Publique Hôpitaux de Paris (AP-HP) EA3518, Université Paris Diderot, Paris.

Background: Good syndrome (GS) is a rare condition in which thymoma is associated with hypogammaglobulinemia. It is characterized by increased susceptibility to bacterial, viral, and fungal infections, as well as autoimmunity. Most patients have no circulating B cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/civ269DOI Listing
July 2015
117 Reads

Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm.

Am J Respir Crit Care Med 2015 Feb;191(4):402-9

1 Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua and Padua City Hospital, Padua, Italy.

Rationale: α1-Antitrypsin (AAT) is a potent protease inhibitor, deficiency of which is associated with the presence of emphysema. An imbalance of elastase and antielastase, along with innate inflammation in the lung, is believed to cause lung destruction in α1-antitrypsin deficiency (AATD). It is now apparent that AAT has important immune-regulatory roles that would be lost in AATD, yet adaptive immune responses in the lung have not been investigated in patients with AATD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201403-0529OCDOI Listing
February 2015
64 Reads

Helicobacter pylori-related diffuse large B-cell lymphoma of the stomach: a distinct entity with lower aggressiveness and higher chemosensitivity.

Blood Cancer J 2014 Jun 20;4:e220. Epub 2014 Jun 20.

1] Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan [2] Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan [3] Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan [4] Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan [5] Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.

We recently showed that Helicobacter pylori (HP)-positive gastric 'pure' diffuse large B-cell lymphoma (DLBCL) may respond to HP eradication therapy. However, whether these HP-related 'pure' DLBCL of the stomach may differ fundamentally from those unrelated to HP remains unclear. In this study, we compared the clinicopathologic features of these two groups of patients who had been uniformly treated by conventional chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/bcj.2014.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080211PMC
June 2014
13 Reads

Secondary pure erythroid leukaemia in relapsed acute lymphoblastic leukaemia: lineage switch or chemotherapy effect?

BMJ Case Rep 2014 May 19;2014. Epub 2014 May 19.

Department of Medical Oncology, All India Institute of Medical Sciences (AIIMS), Delhi, India.

Pure erythroid leukaemia is a rare subtype of acute myeloid leukaemia (AML) and its occurrence at acute lymphoblastic leukaemia (ALL) relapse has not been reported earlier. A 39-year-old man received chemotherapy for Philadelphia-negative B cell ALL. Subsequently, he developed pure erythroid leukaemia with >80% immature erythroid precursors in bone marrow showing block positivity on periodic acid-Schiff stain, expressing CD71, CD34 but lacking CD235a. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2013-201724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039854PMC
May 2014
19 Reads

Anterior panhypopituitarism in diffuse large B-cell stage IV lymphoma.

J Clin Neurosci 2014 Aug 16;21(8):1464-6. Epub 2014 Apr 16.

Division of Endocrinology, Department of Medicine, National University Hospital Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 10, Singapore 119228, Singapore.

The most common presentation of metastases to the pituitary gland in systemic lymphoma is diabetes insipidus resulting from infiltration of the infundibulum/posterior lobe. We describe a 69-year-old man with diffuse large B-cell stage IV lymphoma who presented with anterior pituitary hypofunction, without features of posterior pituitary involvement. He presented with a few months of postural dizziness and hypotension, weight loss, fever, strabismus of right eye and a superficial abdominal wall mass. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09675868140006
Publisher Site
http://dx.doi.org/10.1016/j.jocn.2013.10.042DOI Listing
August 2014
7 Reads

Pure red cell aplasia complicating the course of long-standing mantle cell lymphoma.

Int J Hematol 2014 Jun 26;99(6):777-81. Epub 2014 Mar 26.

Department of Haematology, School of Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece.

Pure red cell aplasia (PRCA) is a rare cause of severe hypoplastic anemia characterized by profound depletion of erythroid precursors. Although PRCA may be associated with lymphoproliferative diseases, it has never been described in mantle cell lymphoma (MCL). We report what to our knowledge is the first case of a patient with indolent, non-nodal MCL complicated by PRCA. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s12185-014-1563
Web Search
http://link.springer.com/10.1007/s12185-014-1563-5
Publisher Site
http://dx.doi.org/10.1007/s12185-014-1563-5DOI Listing
June 2014
40 Reads

Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior.

Mod Pathol 2014 Aug 3;27(8):1116-25. Epub 2014 Jan 3.

Department of Pathology, National Taiwan University Hospital of Medicine, Taipei, Taiwan.

Primary gastric diffuse large B-cell lymphomas may or may not have a concurrent component of mucosa-associated lymphoid tissue lymphoma. Diffuse large B-cell lymphoma/mucosa-associated lymphoid tissue lymphomas are often associated with Helicobacter pylori (H. pylori) infection, suggesting that the large cells are transformed from mucosa-associated lymphoid tissue lymphomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/modpathol.2013.229DOI Listing
August 2014
15 Reads

Autoimmune cytopenias in chronic lymphocytic leukemia, facts and myths.

Mediterr J Hematol Infect Dis 2013 Nov 4;5(1):e2013068. Epub 2013 Nov 4.

Division of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

CLL has been defined as presence of more than 5000 small mature appearing monoclonal B lymphocytes with a specific immunophenotype in peripheral blood. It is a well-known fact that CLL is associated with autoimmune cytopenias. CLL cells are CD5(+) B lymphocytes, and usually are not the "guilty" cells which produce autoantibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4084/MJHID.2013.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867225PMC
November 2013
144 Reads

Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation.

Nucleic Acids Res 2014 Jan 3;42(1):249-63. Epub 2013 Oct 3.

Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Avda. Gran Via 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain, Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain, Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh, Center for Integrated Protein Science and Adolf-Butenandt Institute, Ludwig Maximilians University of Munich, 80336 Munich, Germany and CR-UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK.

Epstein-Barr virus (EBV) infects and transforms human primary B cells inducing indefinite proliferation. To investigate the potential participation of chromatin mechanisms during the EBV-mediated transformation of resting B cells we performed an analysis of global changes in histone modifications. We observed a remarkable decrease and redistribution of heterochromatin marks including H4K20me3, H3K27me3 and H3K9me3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874198PMC
January 2014
54 Reads

Pure anterograde memory deficit due to secondary lymphoma of the fornix.

Eur Neurol 2013 26;70(3-4):242. Epub 2013 Sep 26.

Neurocenter, Genolier Clinic, Genolier Swiss Medical Network, Genolier, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000351781DOI Listing
June 2014
7 Reads

Thyroid lymphoma: recent advances in diagnosis and optimal management strategies.

Oncologist 2013 23;18(9):994-1003. Epub 2013 Jul 23.

Department of Endocrine Surgery, St. Vincent's University Hospital, Dublin, Ireland.

Primary thyroid lymphoma is rare, composing approximately 5% of all thyroid malignancies and less than 3% of all extranodal lymphomas. It typically presents as a rapidly enlarging goiter with associated compressive symptoms. Thyroid ultrasound and fine needle aspiration cytology, using flow cytometry and immunohistochemistry, remain the main modalities used to confirm the presence of lymphoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1634/theoncologist.2013-0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780647PMC
September 2014
22 Reads

Autoimmune cytopenias in chronic lymphocytic leukemia.

Clin Dev Immunol 2013 16;2013:730131. Epub 2013 Apr 16.

Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy.

The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (AG) are, indeed, more rarely seen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2013/730131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652131PMC
December 2013
14 Reads

Clinicopathological prognostic indicators in 107 patients with diffuse large B-cell lymphoma transformed from follicular lymphoma.

Cancer Sci 2013 Jul 25;104(7):952-7. Epub 2013 Apr 25.

Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.

Follicular lymphoma (FL) frequently transforms into diffuse large B-cell lymphoma (DLBCL). To clarify the associated clinicopathological prognostic parameters, we examined the correlation of 11 histopathological parameters with progression-free survival (PFS) and overall survival (OS) in 107 consecutive patients who had DLBCL with pre-existing (asynchronous) or synchronous FL. The patients comprised 58 men and 49 women with a median age of 56 years. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cas.12158
Publisher Site
http://dx.doi.org/10.1111/cas.12158DOI Listing
July 2013
11 Reads

Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD components.

Am J Hematol 2013 Mar;88(3):219-24

Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

Some patients with systemic mastocytosis have concurrent hematological neoplasms, designated in the World Health Organization (WHO) classification as systemic mastocytosis with associated clonal hematological non-mast cell lineage disease (SM-AHNMD). In this study, we analyzed 29 patients with SM-AHNMD and compared them to 40 patients with pure SM. The AHNMDs were classified as chronic myelomonocytic leukemia (CMML) (n = 10), myelodysplastic syndrome (MDS) (n = 7), myeloproliferative neoplasms (n = 4), B-cell lymphoma/leukemia/plasma cell neoplasms (n = 7), and acute myeloid leukemia (n = 1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajh.23380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188390PMC
March 2013
51 Reads