214 results match your criteria Pure B-Cell Disorders

Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model.

Arch Razi Inst 2021 Dec 30;76(6):1755-1764. Epub 2021 Dec 30.

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Iraq.

One of the main causes of acute kidney injury is ischemic reperfusion injury (IRI). Inflammatory response, apoptotic damages, and oxidative stress-related injuries are all involved in the pathogenesis of IRI. Toll-like receptors (TLR) are strongly associated with IRIs, especially TLR4, which is markedly induced in response to IRI. Read More

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December 2021

How Epstein-Barr virus envelope glycoprotein gp350 tricks the CR2? A molecular dynamics study.

J Mol Graph Model 2022 Jul 26;114:108196. Epub 2022 Apr 26.

Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey. Electronic address:

The connection of Epstein Barr virus (EBV) with diseases such as Burkitt Lymphoma, Hodgkin disease, multiple sclerosis, systemic lupus erythematosus and various B-cell lymphomas made EBV glycoproteins one of the most popular vaccine immunogens. As a protein being encoded by EBV, the viral membrane envelope protein gp350 is studied extensively due to its abundancy on the surface and its interaction with complementary receptor, CR2. The binding of CR2 and gp350 not only leads to the entrance of the virus to the B-cells, but also prevents CR2 and C3d protein interactions that are required for immune response. Read More

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T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion.

J Immunother Cancer 2022 Mar;10(3)

Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands

Background: T cell receptor (TCR)-engineered cells can be powerful tools in the treatment of malignancies. However, tumor resistance by Human Leukocyte antigen (HLA) class I downregulation can negatively impact the success of any TCR-mediated cell therapy. Allogeneic natural killer (NK) cells have demonstrated efficacy and safety against malignancies without inducing graft-versus-host-disease, highlighting the feasibility for an 'off the shelf' cellular therapeutic. Read More

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CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disorders.

Medicine (Baltimore) 2021 Nov;100(47):e27874

Department of Hematology, Zhongshan Hospital, Xiamen University, Fujian Medical University Clinic Teaching Hospital, Xiamen, Fujian, China.

Rationale: Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic clonal plasma cell or lymphoplasmacytic proliferative disorder. Recently, some case reports have described the association of pure red cell aplasia (PRCA) with MGUS, even with a relatively low monoclonal immunoglobulin burden. T large granular lymphocyte leukemia (T-LGLL) is a chronic lymphoproliferative disorder characterized by clonal expansion of T large granular lymphocytes, which is rare in China. Read More

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November 2021

High Counts of CD68+ and CD163+ Macrophages in Mantle Cell Lymphoma Are Associated With Inferior Prognosis.

Front Oncol 2021 30;11:701492. Epub 2021 Aug 30.

Department of Pathology, Yale University School of Medicine, New Haven, CT, United States.

Background: Lymphoma-associated macrophages (LAMs) are key components in the lymphoma microenvironment, which may impact disease progression and response to therapy. There are two major subtypes of LAMs, CD68+ M1 and CD163+ M2. M2 LAMs can be transformed from M1 LAMs, particularly in certain diffuse large B-cell lymphomas (DLBCL). Read More

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Isolation, Characterization and Neuroprotective Activity of Folecitin: An In Vivo Study.

Life (Basel) 2021 Aug 12;11(8). Epub 2021 Aug 12.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

Neurodegenerative diseases (NDs) extend the global health burden. Consumption of alcohol as well as maternal exposure to ethanol can damage several neuronal functions and cause cognition and behavioral abnormalities. Ethanol induces oxidative stress that is linked to the development of NDs. Read More

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Successful treatment of refractory pure red cell aplasia with eltrombopag after ABO-incompatible allogeneic hematopoietic stem cell transplantation.

J Zhejiang Univ Sci B 2021 Aug;22(8):695-700

Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Pure red cell aplasia (PRCA) is a well-recognized complication of ABO major mismatched allogeneic hematopoietic stem cell transplantation (allo-HSCT), with a reported incidence of 10%-20% (Zhidong et al., 2012; Busca et al., 2018). Read More

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Autoimmune Cytopenia in CLL: Prognosis and Management in the Era of Targeted Therapies.

Cancer J 2021 Jul-Aug 01;27(4):286-296

From the Department of Hematology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.

Abstract: Chronic lymphocytic leukemia (CLL) is frequently associated with autoimmune hemolytic anemia and immune thrombocytopenia and, less frequently, with pure red cell aplasia and immune neutropenia. The emergence of these complications is related to an intertwined and complex relationship between patient, disease, and treatment characteristics. The prognostic repercussion of autoimmune cytopenia (AIC) in patients with CLL mainly depends on its response to therapy. Read More

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October 2021

Histopathological findings in the landscape of IgG4-related pathology in patients with pituitary dysfunction: Review of six cases.

J Neuroendocrinol 2021 03 21;33(3):e12942. Epub 2021 Feb 21.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

IgG4-related hypophysitis (IgG4-RH) is increasingly being reported as an isolated entity or, less frequently, as a manifestation of a multiorgan IgG4-related disease (IgG4-RD), in which typical histopathology is a cornerstone for the diagnosis. We aimed to describe the histopathological changes in the surgical specimens from patients with clinical signs of pituitary disease that fulfilled the current diagnostic criteria for IgG4-RH. Histopathological features were correlated with clinical and radiological findings. Read More

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SLy2-overexpression impairs B-cell development in the bone marrow and the IgG response towards pneumococcal conjugate-vaccine.

Immun Inflamm Dis 2021 06 16;9(2):533-546. Epub 2021 Feb 16.

Department of Pharmacology, Experimental Therapy and Toxicology, Institute of Experimental and Clinical Pharmacology and Pharmacogenomik and ICePhA, University of Tuebingen, Tuebingen, Germany.

Background: Infections with Streptococcus pneumoniae can cause severe diseases in humans including pneumonia. Although guidelines for vaccination have been established, S. pneumoniae is still responsible for a serious burden of disease around the globe. Read More

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Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases.

Cancers (Basel) 2021 Jan 16;13(2). Epub 2021 Jan 16.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32-80; lesion diameter 7. Read More

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January 2021

Anti-carbamylated protein antibody isotype pattern differs between palindromic rheumatism and rheumatoid arthritis.

Ther Adv Musculoskelet Dis 2020 10;12:1759720X20978139. Epub 2020 Dec 10.

Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Villarroel 170, Barcelona, 08036, Spain.

Background: A restricted response against citrullinated peptides/proteins, with less isotype usage, has been found in palindromic rheumatism (PR) in comparison with rheumatoid arthritis (RA). We hypothesized that this different antibody response may be observed for other post-translational modified proteins. We compared the prevalence and isotype usage of two specificities of anti-carbamylated peptide/protein antibodies (Anti-CarP) in patients with PR and RA. Read More

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December 2020

Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome.

Rheumatology (Oxford) 2021 05;60(5):2396-2408

Research and Development, GlaxoSmithKline, Stevenage.

Objectives: To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-fluorodeoxyglucose (18F-FDG; glucose uptake marker), to assess protein synthesis and inflammation, respectively; multiparametric MRI evaluated salivary gland structural and physiological changes.

Methods: In this imaging/clinical/histology comparative study (GSK study 203818; NCT02899377) patients with pSS and age- and sex-matched healthy volunteers underwent MRI of the salivary glands and 11C-MET PET-CT. Patients also underwent 18F-FDG PET-CT and labial salivary gland biopsies. Read More

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Exploration of surface glycoprotein to design multi-epitope vaccine for the prevention of Covid-19.

Inform Med Unlocked 2020 4;21:100438. Epub 2020 Oct 4.

Department of Natural Sciences, Precious Conerstone University, Ibadan, Oyo State, Nigeria.

Stimulation and generation of T and B cell-mediated long-term immune response are essential for the curbing of a deadly virus such as SAR-CoV-2 (Severe Acute Respiratory Corona Virus 2). Immunoinformatics approach in vaccine design takes advantage of antigenic and non-allergenic epitopes present on the spike glycoprotein of SARS-CoV-2 to elicit immune responses. T cells and B cells epitopes were predicted, and the selected residues were subjected to allergenicity, antigenicity and toxicity screening which were linked by appropriate linkers to form a multi-epitope subunit vaccine. Read More

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October 2020

Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficiency patients.

Eur J Immunol 2021 01 28;51(1):206-219. Epub 2020 Aug 28.

Unità Operativa Semplice Dipartimentale Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Adenosine deaminase 2 deficiency (DADA2) is an autoinflammatory disease characterized by inflammatory vasculopathy, early strokes associated often with hypogammaglobulinemia. Pure red cell aplasia, thrombocytopenia, and neutropenia have been reported. The defect is due to biallelic loss of function of ADA2 gene, coding for a protein known to regulate the catabolism of extracellular adenosine. Read More

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January 2021

Psychiatric Disturbance or Parkinsonism as a Presentation of CNS Lymphoma: Observational Retrospective Study and Review of Literature.

Am J Clin Oncol 2020 10;43(10):727-733

Departments of Neurology.

Objective: To evaluate the incidence of and characterize the presentation of neuropsychiatric symptoms and/or Parkinsonism as a presentation of central nervous system lymphoma (CNSL) in either its primary CNSL form or when it spreads to the brain in systemic diffuse large B-cell lymphoma (secondary CNSL).

Patients And Methods: With Institutional Review Board approval we identified patients who had been treated at Mayo Clinic from 1998 to 2018 and were recorded to have a combination of ICD 9/10 codes for CNSL and various psychiatric diagnoses.

Results: A total of 20 of the 232 patients (9%) were noted to have neuropsychiatric symptoms preceding diagnosis. Read More

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October 2020

Intrasinusoidal HHV8-EBV-Positive Large B-Cell Lymphoma With Features of Germinotropic Lymphoproliferative Disorder.

Int J Surg Pathol 2020 Oct 18;28(7):804-811. Epub 2020 May 18.

Hospital Clinico Universitario of Valencia, University of Valencia, Valencia, Spain.

Germinotropic lymphoproliferative disorder (GLPD) is a poorly characterized lymphoproliferative entity, recently included in the World Health Organization classification of hematolymphoid neoplasms. The histological pattern of this disease comprises monotypic plasmablasts that involve the germinal centers of the lymphoid follicles (germinotrophism), forming confluent aggregates positive for both human herpes virus type 8 (HHV8) and Epstein-Barr virus. Currently, after 17 years of its first description, only 18 cases have been reported. Read More

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October 2020

Isolation of Trypanosoma brucei brucei Infection-Derived Splenic Marginal Zone B Cells Based on CD1d/B220 Surface Expression in a Two-Step MACS-FACS Approach.

Methods Mol Biol 2020 ;2116:739-753

Biomedical Research Center (BMRC), Department of Environmental Tech, Food Tech, and Molecular Biotechnology, Ghent University, Incheon, South Korea.

Magnetic- and fluorescent-activated cell sorting (MACS and FACS) are used for isolation of distinct cell populations for subsequent studies including transcriptomics. The latter allows for the analysis of infection-induced alterations in gene expression profiles. MACS and FACS both use antibodies against cell surface molecules to isolate populations of interest. Read More

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February 2021

The prognostic significance of immune microenvironment in breast ductal carcinoma in situ.

Br J Cancer 2020 05 17;122(10):1496-1506. Epub 2020 Mar 17.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK.

Background: The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS.

Methods: A well characterised DCIS cohort (n = 700) with long-term follow-up comprising pure DCIS (n = 508) and DCIS mixed with invasive carcinoma (IBC; n = 192) were stained immunohistochemically for CD20, CD3, CD4, CD8, FOXP3, PD1 and PDL1. Read More

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Antioxidant, Antiproliferative and Apoptosis-Inducing Efficacy of Fractions from L. Leaves.

Antioxidants (Basel) 2020 Feb 20;9(2). Epub 2020 Feb 20.

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.

Cassia fistula L. is a highly admirable traditional medicinal plant used for the treatment of various diseases and disorders. The present study was performed to divulge the antioxidant, antiproliferative, and apoptosis-inducing efficacy of fractions from leaves. Read More

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February 2020

The many (sur)faces of B cells.

Biomed J 2019 08 3;42(4):201-206. Epub 2019 Oct 3.

University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Ole Maaløes Vej 5, 2200 Copenhagen Denmark. Electronic address:

This issue of the Biomedical Journal is dedicated to the latest findings concerning the complex development and functions of B lymphocytes, including their origins during embryogenesis, their meticulous control by the CD22 receptor and different types of T cells, as well as the immunosuppressive abilities of certain B cell subsets. Furthermore, we learn about the complicated genetic background of a rare cardiac disease, the surgical outcomes of pure conus medullaris syndrome and occurrences of tuberculous spondylitis after percutaneous vertebroplasty. Finally, we discover that brain waves could very well be used for biometric authentication and that diffusion imaging displays good reproducibility through a spectrum of spatial resolutions. Read More

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Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma.

Am J Clin Pathol 2020 01;153(2):156-164

Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.

Objectives: To assess the prevalence of Hashimoto thyroiditis (HT) in primary thyroid lymphoma (PTL) and whether it differs between mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBCL).

Methods: Electronic databases were searched for studies assessing HT prevalence in PTL, based on antithyroid antibodies, clinical history, or pathology. Pooled prevalence of HT and its association with histotype (MALT or DLBCL) were calculated. Read More

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January 2020

Traceless aptamer-mediated isolation of CD8 T cells for chimeric antigen receptor T-cell therapy.

Nat Biomed Eng 2019 10 17;3(10):783-795. Epub 2019 Jun 17.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

Chimeric antigen receptor T-cell therapies using defined product compositions require high-purity T-cell isolation systems that, unlike immunomagnetic positive enrichment, are inexpensive and leave no trace on the final cell product. Here, we show that DNA aptamers (generated with a modified cell-SELEX procedure to display low-nanomolar affinity for the T-cell marker CD8) enable the traceless isolation of pure CD8 T cells at low cost and high yield. Captured CD8 T cells are released label-free by complementary oligonucleotides that undergo toehold-mediated strand displacement with the aptamer. Read More

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October 2019

Establishment and Expression of Cytokines in a -Infected Bovine B Cell Line.

Genes (Basel) 2019 04 30;10(5). Epub 2019 Apr 30.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, China.

This study aimed to establish a pure single-cell -infected B cell line for the assessment of cytokine production in transformed and lipopolysaccharide (LPS)-stimulated cells. Several studies have aimed to identify cell surface markers in -transformed cells; however, no information on cytokine production in these cells is available. To investigate the potential of the transformed cells to produce cytokines and their potential responses to antigen-stimulation, we purified mature B cells (CD21) from the whole blood of cattle experimentally infected with the Kashi strain by magnetic separation. Read More

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Cutaneous localization of plasmablastic multiple myeloma with heterotopic expression of CD3 and CD4: Skin involvement revealing systemic disease.

J Cutan Pathol 2019 Aug 10;46(8):619-622. Epub 2019 May 10.

Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.

Plasmablastic multiple myeloma is an uncommon morphological variant of multiple myeloma with aggressive clinical course and poor outcome. Its differential diagnosis includes plasmablastic lymphoma, a variant of diffuse large B-cell lymphoma with frequent extranodal presentation, which usually affects immunosuppressed patients and is virtually indistinguishable from plasmablastic multiple myeloma on the basis of histology solely. Differential diagnosis relies on close clinical-pathological correlation. Read More

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Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma.

Eur J Haematol 2019 Jul 30;103(1):35-42. Epub 2019 May 30.

Service de médecine interne, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est, Créteil, France.

Objective: Angioimmunoblastic T-cell lymphoma (AITL) is frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear.

Method: Angioimmunoblastic T-cell lymphoma patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1/5 ratio). Read More

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The prevalence and prognostic significance of autoimmune cytopenias in a cohort of Egyptian patients with chronic lymphocytic leukemia.

Hematol Oncol Stem Cell Ther 2019 Jun 20;12(2):97-104. Epub 2019 Feb 20.

The Hematology Unit, Oncology Center, Mansoura University, Mansoura, Egypt. Electronic address:

Objective/background: The impact of autoimmune cytopenias (AICs) on the chronic lymphocytic leukemia (CLL) clinical course and its prognostic significance remain a matter of controversial debate. This could be due to exclusion of patients with cytopenia from most clinical trials for this particular complication and the lack of standard diagnostic criteria and treatment approaches. We herein evaluate the prevalence and the prognostic significance of AICs among patients with CLL. Read More

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Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study.

Blood 2019 02 21;133(6):576-587. Epub 2018 Dec 21.

Department of Nephrology, CHU Poitiers, Poitiers, France.

Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of B-cell clonal disorders, defined by Congo red negative-deposits of monoclonal light chain (LCDD), heavy chain (HCDD), or both (LHCDD). MIDD is a systemic disorder with prominent renal involvement, but little attention has been paid to the description of extrarenal manifestations. Moreover, mechanisms of pathogenic immunoglobulin deposition and factors associated with renal and patient survival are ill defined. Read More

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February 2019

Bidirectional effects of IL-10 regulatory B cells in Ldlr mice.

Atherosclerosis 2019 01 9;280:118-125. Epub 2018 Nov 9.

Division of BioTherapeutics, LACDR, Leiden University, Leiden, the Netherlands.

Background And Aims: Limiting the pro-inflammatory immune response is critical for the treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response through interleukin-10 (IL-10). Current data regarding Bregs and atherosclerosis is scarce and conflicting. Read More

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January 2019

B cell responses to apoptotic cells in MFG-E8-/- mice.

YuFeng Peng

PLoS One 2018 4;13(10):e0205172. Epub 2018 Oct 4.

Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, United States of America.

Defective clearance of apoptotic cells in MFG-E8 deficient mice results in lupus-like disease in the mixed B6x129, but not pure B6 background. The lack of overt autoimmunity in MFG-E8-/- B6 mice suggests that accumulation of apoptotic cells is not sufficient to break central tolerance. However, the delayed clearance of apoptotic cells in the follicles of MFG-E8-/- B6 mice provides an excellent opportunity to investigate how B cells respond to excessive apoptotic cells in the periphery under relatively non-inflammatory conditions. Read More

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