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    Association of frailty status with acute kidney injury and mortality after transcatheter aortic valve replacement: A systematic review and meta-analysis.
    PLoS One 2017 18;12(5):e0177157. Epub 2017 May 18.
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States of America.
    Objective: Frailty is a common condition in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). The aim of this systematic review was to assess the impact of frailty status on acute kidney injury (AKI) and mortality after TAVR.

    Methods: A systematic literature search was conducted using MEDLINE, EMBASE, and Cochrane databases from the inception through November 2016. Read More

    Acute Aortic Regurgitation in the Current Era of Percutaneous Treatment: Pathophysiology and Hemodynamics.
    J Heart Valve Dis 2017 Jan;26(1):22-31
    Gulhane Military Medical Academy, Department of Cardiology, Ankara, Turkey.
    Aortic regurgitation (AR) is characterized by the backflow of blood from the aorta to the left ventricle. Acute AR typically causes severe pulmonary edema and hypotension, and is a surgical emergency. In chronic AR, however, compensatory mechanisms can clinically compensate for years, with normal left ventricular function and no symptoms. Read More

    Long-term respiratory outcomes after primary total correction for tetralogy of Fallot and absent pulmonary valve in patient with respiratory symptoms.
    Congenit Heart Dis 2017 May 19. Epub 2017 May 19.
    Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
    Objective: To review long-term respiratory outcomes for tetralogy of Fallot and absent pulmonary valve (TOF/APV) in respiratory symptomatic populations.

    Methods: Of 25 consecutive patients undergoing primary total correction for TOF/APV between 1987 and 2016, Sixteen patients (64%) with a preoperative respiratory disturbance were enrolled. The median age at operation was 1. Read More

    Surgical repair of partial atrioventricular septal defect.
    Pak J Med Sci 2017 Mar-Apr;33(2):285-289
    Muhammad Shuaib, FCPS, Registrar, Paediatric Cardiac Surgery, CPE Institute of Cardiology, Multan, Pakistan.
    Objective: To review the results of surgical correction of partial atrioventricular septal defect and associated cardiac comorbidities.

    Methods: Retrospective case analysis of electronic database of department of paediatrics cardiac surgery, CPEIC, Multan was done. Forty consecutive patients operated for partial atrioventricular septal defect repair from September 2011 to October 2016 were included. Read More

    Common origin of all three coronary arteries from the right sinus of Valsalva - first case study accompanied by mitral valve prolapse and vein anomaly, second case study followed by successful percutaneous coronary intervention of right coronary artery stenosis.
    Kardiochir Torakochirurgia Pol 2017 Mar 31;14(1):66-70. Epub 2017 Mar 31.
    Department of Doctoral Studies, University of Economics, Katowice, Poland.
    Congenital anomalies of the coronary arteries can be divided into two broad categories: those that alter myocardial perfusion and those that do not. In coronary anomalies not altering myocardial perfusion, the coronary arteries originate from the aorta, but their origins are in unusual positions. Although myocardial perfusion is normal, the angiographer may have trouble locating them. Read More

    Total Correction of Tetralogy of Fallot at Early Age: A Study of 183 Cases.
    Heart Lung Circ 2017 Apr 27. Epub 2017 Apr 27.
    Cardiothoracic Surgery Department, Zagazig University, Egypt.
    Background: Opinions regarding the optimal time for the repair of tetralogy of Fallot vary. A debate also exists about the timing of repair for the asymptomatic infant.

    Methods: This study included 183 patients with tetralogy of Fallot. Read More

    Ross-Konno Procedure With Cylinder Mitral Valve Replacement in 49 Days Old Infant.
    World J Pediatr Congenit Heart Surg 2017 Jan 1:2150135116688173. Epub 2017 Jan 1.
    1 Department of Cardiac Surgery, Ukrainian Children's Cardiac Center, Kyiv, Ukraine.
    A neonate with antenatally diagnosed severe aortic valve stenosis, left ventricular outflow tract obstruction, left ventricular endocardial fibroelastosis, and severe mixed mitral valve disease was admitted to our center for balloon aortic valvuloplasty. On day 49, we performed a Ross-Konno procedure and mitral valve replacement on the baby, whose weight was 3.4 kg. Read More

    Stress Testing in Asymptomatic Aortic Stenosis.
    Circulation 2017 May;135(20):1956-1976
    From Clinical Trials Center, Cardiovascular Research Foundation, New York (B.R., D.B., M.B.L., P.G.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Pulmonary Hypertension and Vascular Biology Research Group, Laval University, Québec, Canada (P.P.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (L.D.G., P.G.); Columbia University Medical Center, New York (D.B., M.B.L., P.G.); Leiden University Medical Center, The Netherlands (J.J.B.); Structural Heart and Valve Center, Vanderbilt University Medical Center, Nashville, TN (B.R.L.); Northwestern University Feinberg School of Medicine, Chicago, IL (R.O.B.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.T.O.); and Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Québec, Canada (P.G.).
    Aortic stenosis is 1 of the most common heart valve diseases among adults. When symptoms develop, prognosis is poor, and current guidelines recommend prompt aortic valve replacement. Depending of the severity of the aortic stenosis and the presence of concomitant heart disease and medical comorbidities, stress testing represents a reasonable strategy to help better risk stratify asymptomatic patients. Read More

    Edwards valve-in-valve implantation in tricuspid position.
    Cardiol Young 2017 May 16:1-4. Epub 2017 May 16.
    1Pediatric Cardiology Department,Hospital Ramón y Cajal,Madrid,Spain.
    We present two cases of percutaneous Sapien XT valve-in-valve implantation in the tricuspid position: a 20-year-old man with severe congenital pulmonary stenosis and percutaneous valvuloplasty, who required surgical implantation of two protheses, pulmonary and tricuspid, and a 12-year-old boy with CHD and a degenerated tricuspid prosthesis. We implanted three Sapien XT valve-in-valves, two in the tricuspid position and one in the pulmonic position. Sapien XT valve-in-valve implantation in the tricuspid position is feasible and can decrease the number of surgeries in CHD patients. Read More

    A cohort study reveals myocarditis to be a rare and life-threatening presentation of large vessel vasculitis.
    Semin Arthritis Rheum 2017 Apr 4. Epub 2017 Apr 4.
    Rheumatology Department, Imperial College Healthcare NHS Trust and Imperial College London, Hammersmith Hospital, London, UK.
    Background: The predominant forms of adult large vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu arteritis (TA). Cardiac involvement in LVV is a cause of morbidity and mortality, particularly in TA. Cardiac failure is most commonly secondary to uncontrolled arterial hypertension or myocardial ischaemia. Read More

    [Surgical Treatment for Anomalous Aortic Origin of Coronary Arteries].
    Kyobu Geka 2017 May;70(5):342-347
    Department of Cardiovascular Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
    Anomalous aortic origin of coronary arteries is rare. We report 3 cases of surgical treatment for anomalous aortic origin of coronary arteries. Case 1 was a 38-year-old man who was saved by the use of an automated external defibrillator from cardiopulmonary arrest while exercising. Read More

    Insights on mid-term TAVR performance: 3-year clinical and echocardiographic results from the CoreValve ADVANCE study.
    Clin Res Cardiol 2017 May 8. Epub 2017 May 8.
    Department of Internal Medicine and Cardiology, University of Leipzig Heart Center, Leipzig, Germany.
    Background: Extensive evidence relating to transcatheter aortic valve replacement (TAVR) has accumulated in recent years, but mid-term outcomes are less reported. We investigated 996 patients after implantation of the CoreValve prosthesis for severe aortic stenosis in a real-world setting.

    Objective: To report clinical and echocardiographic 3-year results from the ADVANCE study. Read More

    The ordeal of left atrioventricular valve replacement in children under 1 year of age†.
    Interact Cardiovasc Thorac Surg 2017 May 2. Epub 2017 May 2.
    Department of Cardiac Surgery, The Royal Children's Hospital, Melbourne, VIC, Australia.
    Objectives: This study reviews the outcomes of children under 1 year of age who had left atrioventricular valve (LAVV) replacement (LAVVR) in one centre and explores the benefits of an innovative approach for LAVVR in very small patients.

    Methods: Thirteen consecutive patients operated for LAVV replacement between 1997 and 2016 were reviewed retrospectively. Indication for surgery was regurgitation in 7, stenosis in 5 and both stenosis and regurgitation in 1. Read More

    miR-21 is associated with fibrosis and right ventricular failure.
    JCI Insight 2017 May 4;2(9). Epub 2017 May 4.
    Combined pulmonary insufficiency (PI) and stenosis (PS) is a common long-term sequela after repair of many forms of congenital heart disease, causing progressive right ventricular (RV) dilation and failure. Little is known of the mechanisms underlying this combination of preload and afterload stressors. We developed a murine model of PI and PS (PI+PS) to identify clinically relevant pathways and biomarkers of disease progression. Read More

    Association of Transcatheter Aortic Valve Replacement With 30-Day Renal Function and 1-Year Outcomes Among Patients Presenting With Compromised Baseline Renal Function: Experience From the PARTNER 1 Trial and Registry.
    JAMA Cardiol 2017 May 3. Epub 2017 May 3.
    Columbia University Medical Center/New York Presbyterian Hospital, New York.
    Importance: The frequency of baseline renal impairment among high-risk and inoperable patients with severe aortic stenosis undergoing a transcatheter aortic valve replacement (TAVR) and the effect of TAVR on subsequent renal function are, to our knowledge, unknown.

    Objective: To determine the effect of TAVR among patients with baseline renal impairment.

    Design, Setting, And Participants: This substudy of patients with baseline renal impairment (estimated glomerular filtration rate [eGFR] ≤ 60 mL/min) and paired baseline and 30-day measures of renal function undergoing TAVR in the PARTNER 1 trial and continued access registries was conducted in 25 centers in the United States and Canada. Read More

    Use of Dobutamine Stress Echocardiography for Periprocedural Evaluation of a Case of Critical Valvular Pulmonary Stenosis with Delayed Presentation.
    J Cardiovasc Echogr 2016 Apr-Jun;26(2):56-60
    Department of Cardiology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
    We report a case illustrating a 39-year-old man with delayed presentation of severe pulmonary valve (PV) stenosis, clinical evidence of congestive right heart failure in the form of enlarged liver, raised jugular venous pressure, and anasarca without cyanosis. Echocardiography (echo) was used both for diagnosis and monitoring this patient as main tool. The contractile reserve of the right ventricle (RV) was evaluated by infusion of dobutamine and diuretic for 4 days before pulmonary balloon valvotomy. Read More

    The impact of frailty on mortality after transcatheter aortic valve replacement.
    Ann Transl Med 2017 Mar;5(6):144
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
    Frailty is a notably common problem in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) evaluation. Studies have demonstrated significant associations between frailty and worse outcomes in patients undergoing TAVR including higher risks of disability and mortality and admissions to long-term care facility. While there are multiple methods to identify and measure frailty, there is a critical need for a precise definition of frailty and its standardized assessment protocol based on well-established tests covering all aspects of the frailty, as a syndrome. Read More

    Transcatheter Aortic Valve Implantation in a Patient with Unicuspid Aortic Valve.
    Tex Heart Inst J 2017 Apr 1;44(2):127-130. Epub 2017 Apr 1.
    Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valves has been successfully performed, but there is a lack of published experience in percutaneous treatment of patients with unicuspid valves and severe aortic stenosis. We describe a case of TAVR in such a patient. A 31-year-old woman with Turner syndrome-who had undergone coarctation repair via subclavian flap at age 7 days and an aortic valvotomy at age 6 weeks-presented with severe symptomatic aortic stenosis. Read More

    Percutaneous balloon valvuloplasty with Inoue balloon catheter technique for pulmonary valve stenosis in adolescents and adults.
    Indian Heart J 2017 Mar - Apr;69(2):176-181. Epub 2017 Mar 1.
    Department of Cardiology, Seth G.S. Medical College & King Edward VII Memorial Hospital, Mumbai, India.
    Background: Percutaneous balloon pulmonary valvuloplasty is the procedure of choice for uncomplicated severe or symptomatic pulmonary stenosis. The present study describes our experience in balloon pulmonary valvuloplasty using the Inoue balloon catheter in adolescent and adult patients.

    Aims: To assess the immediate and mid-term outcomes of percutaneous balloon valvuloplasty with Inoue balloon catheter in adolescent and adult patients. Read More

    Prevalence, predictors, and prognostic implications of residual impairment of functional capacity after transcatheter aortic valve implantation.
    Clin Res Cardiol 2017 Apr 25. Epub 2017 Apr 25.
    Hospital Israelita Albert Einstein, São Paulo, Brazil.
    Background: Patients with degenerative aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI) typically have advanced cardiac and vascular adverse remodeling and multiple comorbidities and, therefore, might not recover a normal functional capacity after valve replacement. We sought to investigate the prevalence, the predictors, and the prognostic impact of residual impairment of functional capacity after TAVI.

    Methods And Results: Out of 790 patients undergoing TAVI with impaired functional capacity (NYHA II-IV) at baseline, NYHA functional class improved in 592 (86. Read More

    Low-Volume Contrast CT Angiography Via Pulmonary Artery Injection for Measurement of Aortic Annulus in Patients Undergoing Transcatheter Aortic Valve Replacement.
    J Invasive Cardiol 2017 May;29(5):181-186
    The Christ Hospital Health Network, 2139 Auburn Avenue, Cincinnati, OH 45219 USA.
    Objectives: To investigate the feasibility and image quality of low-dose contrast computed tomography (CT) angiography with pulmonary artery (PA) protocol.

    Background: Aortic stenosis is the most common valvular heart disease and transcatheter aortic valve replacement (TAVR) has evolved as an alternative method for surgical valve replacement in intermediate-risk and high-risk surgical patients. CT is essential for measurement of aortic annulus prior to TAVR. Read More

    Impact of pulmonary hypertension on in-hospital outcome after surgical or transcatheter aortic valve replacement.
    EuroIntervention 2017 Apr 25. Epub 2017 Apr 25.
    University Heart Center Freiburg, Department of Cardiology and Angiology I, Freiburg, Germany.
    Aims: The impact of pulmonary hypertension (PH) on in-hospital outcome of either surgical (SAVR) or transcatheter aortic valve replacement (TAVR) was analyzed.

    Methods And Results: Data from all 107,057 patients undergoing isolated SAVR or TAVR in Germany between 2007 and 2014 was provided by the German Federal Bureau of Statistics. About 18% of patients with aortic valve stenosis suffered from PH. Read More

    Surgical Strategy Toward Biventricular Repair for Severe Ebstein Anomaly in Neonates and Infancy.
    Ann Thorac Surg 2017 Apr 20. Epub 2017 Apr 20.
    Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
    Background: Neonates with severe forms of Ebstein anomaly present a surgical challenge, and the Starnes operation as single ventricle palliation is highly advocated. Cone reconstruction for tricuspid valvuloplasty (TVP) has become a widely accepted technique, although very few cases of TVP have been reported in neonates. This report describes a surgical strategy for neonatal Ebstein anomaly, with an aim toward biventricular repair. Read More

    Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study.
    Heart 2017 Apr 21. Epub 2017 Apr 21.
    Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
    Objective: Transitions in the spectrum of valvular heart diseases (VHDs) in developed countries over the 20th century have been reported from clinical case series, but large, contemporary population-based studies are lacking.

    Methods: We used nationwide registers to identify all patients with a first diagnosis of VHD at Swedish hospitals between 2003 and 2010. Age-stratified and sex-stratified incidence of each VHD and adjusted comorbidity profiles were assessed. Read More

    Intentional Percutaneous Laceration of the Anterior Mitral Leaflet to Prevent Outflow Obstruction During Transcatheter Mitral Valve Replacement: First-in-Human Experience.
    JACC Cardiovasc Interv 2017 Apr;10(8):798-809
    Cardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:
    Objectives: This study sought to use a new catheter technique to split the anterior mitral valve leaflet (AML) and prevent iatrogenic left ventricular outflow tract (LVOT) obstruction immediately before transcatheter mitral valve replacement (TMVR).

    Background: LVOT obstruction is a life-threatening complication of TMVR, caused by septal displacement of the AML.

    Methods: The procedure was used in patients with severe mitral valve disease and prohibitive surgical risk. Read More

    Chronic Atrial Fibrillation Ablation with Harmonic Scalpel during Mitral Valve Surgery.
    Braz J Cardiovasc Surg 2017 Jan-Feb;32(1):22-28
    Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil and Universidade de Campinas (UNICAMP), Campinas, SP, Brazil.
    Objective: To evaluate surgical treatment of chronic atrial fibrillation with ultrasound in patients with mitral valve disease, considering preoperative clinical characteristics of patients undergoing surgical procedure and follow-up in the immediate postoperative period, in hospital and up to 60 months after discharge.

    Methods:: We studied 100 patients with chronic atrial fibrillation and mitral valve disease who underwent surgical treatment using ultrasound ablation. Patient data were reviewed by consulting the control reports, including signs and symptoms, underlying disease, functional class, hospital stay, surgical procedure time, ablation time, immediate complications, and complications at discharged and up to 60 months later. Read More

    Outcome of isolated aortic valve replacement in patients with classic and paradoxical low-flow, low-gradient aortic stenosis.
    J Thorac Cardiovasc Surg 2017 Mar 12. Epub 2017 Mar 12.
    Department of Cardiothoracic Surgery, Morriston Hospital, Swansea, United Kingdom.
    Objective: To analyze operative outcomes and mid-term results after isolated aortic valve replacement (AVR) in low-flow, low-gradient aortic stenosis (LFLG AS) by comparing the 2 subcategories (classic low-flow, low-gradient aortic stenosis [CLFLG] and paradoxical low-flow, low-gradient aortic stenosis [PLFLG]).

    Methods: This was a retrospective analysis of prospectively collected data for all isolated AVR in LFLG AS performed in our center during the last 13 years (n = 198; CLFLG AS, n = 66, 33% and PLFLG AS, n = 132, 67%). Median follow-up was 3. Read More

    Reversal of abnormal cardiac parameters following mitral valve replacement for severe mitral stenosis in relation to pulmonary artery pressure: A retrospective study of noninvasive parameters - Early and late pattern.
    Interv Med Appl Sci 2016 Jun;8(2):49-59
    MPS Hospital, Department of Cardiac Surgery, Peoples' Friendship University of Russia , Moscow, Russian Federation.
    Background And Objectives: Although the regression of pulmonary hypertension (PH) in mitral stenosis (MS) has been studied over varying periods postintervention, corresponding studies on the cardiac chamber alterations after surgery are very limited. We sought to determine the degree of reversal of these and the clinical status in connection with that of pulmonary artery pressures (PAPs) in the early and late postoperative periods.

    Methods: The preoperative, early, and 1-year postoperative data - functional class (FC), cardiothoracic ratio (CTR) in chest X-ray (CXR), and echocardiographically left atrium (LA), right atrium (RA), right ventricle (RV), left ventricle (LV), and pulmonary artery (PA) dimensions, PAP, tricuspid regurgitation (TR) - of 50 patients who had mitral valve replacement (MVR) for MS with PH were retrospectively analyzed for correlations with PAP (Pearson's), and their change (t-test), in relation to that in PAP. Read More

    Tricuspid Regurgitation Does Not Impact Right Ventricular Remodeling After Percutaneous Pulmonary Valve Implantation.
    JACC Cardiovasc Interv 2017 Apr;10(7):701-708
    Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Centre of the Technical University Munich, Munich, Germany.
    Objectives: This study sought to investigate the impact of tricuspid regurgitation (TR) on right ventricular function after percutaneous pulmonary valve implantation (PPVI).

    Background: PPVI provides a less invasive alternative to surgery in patients with right ventricular-to-pulmonary artery (RV-PA) conduit dysfunction. Recovery of the right ventricle has been described after PPVI for patients with pulmonary stenosis and for those with pulmonary regurgitation. Read More

    Immediate Outcome of Balloon Mitral Valvuloplasty with JOMIVA Balloon during Pregnancy.
    J Clin Diagn Res 2017 Feb 1;11(2):OC18-OC20. Epub 2017 Feb 1.
    Assistant Professor, Department of Cardiology, PSG Institute of Medical Sciences and Research , Coimbatore, Tamil Nadu, India .
    Introduction: Rheumatic mitral stenosis is the most common Valvular Heart Disease encountered during pregnancy. Balloon Mitral Valvuloplasty (BMV) is one of the treatment option available if the symptoms are refractory to the medical management and the valve anatomy is suitable for balloon dilatation. BMV with Inoue balloon is the most common technique being followed worldwide. Read More

    Bispectral index-guided sedation in transfemoral transcatheter aortic valve implantation: a retrospective control study.
    J Zhejiang Univ Sci B 2017 Apr.;18(4):353-359
    Department of Anesthesia, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
    Objective: Transcatheter aortic valve implantation (TAVI) is a minimally invasive therapy for elderly patients with severe aortic valve stenosis who were refused surgical aortic valve replacement because of the high perioperative risk. Traditionally, this procedure has been done under general anesthesia, but more recently local anesthesia and sedation have become popular. This research assessed the effectiveness of transfemoral TAVI under bispectral index (BIS)-guided sedation. Read More

    Coronary flow reserve in mitral stenosis before and after percutaneous balloon mitral valvuloplasty.
    Int J Cardiovasc Imaging 2017 Apr 4. Epub 2017 Apr 4.
    Cardiology Department, Zagazig University Hospital, Zagazig, Egypt.
    We aimed to evaluate the coronary flow reserve (CFR) before and after percutaneous balloon mitral valvuloplasty (PBMV) in patients with mitral stenosis (MS) and its association to clinical events. A prospective study included 45 patients with mitral stenosis candidate for PBMV (age 38 ± 19 years, 27 were females) and 20 with matched age and sex, healthy controls were included in the study. Noninvasive CFR was measured using transthoracic echocardiography and utilizing adenosine stress echocardiography (0. Read More

    Maternal Antihypertensive Medication Use and Congenital Heart Defects: Updated Results From the National Birth Defects Prevention Study.
    Hypertension 2017 May 3;69(5):798-805. Epub 2017 Apr 3.
    From the Congenital Malformations Registry, New York State Department of Health, Albany (S.C.F., A.R.V.Z., C.M.D., M.L.B.); Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY (A.R.V.Z., C.M.D., M.L.B.); Department of Epidemiology, School of Public Health, Boston University, MA (M.M.W.); Genetics Unit, MassGeneral Hospital for Children, Boston, MA (A.E.L.); Massachusetts Department of Public Health, Massachusetts Center for Birth Defects Prevention, Boston (A.E.L.); and Department of Epidemiology, College of Public Health, University of Iowa, Iowa City (P.A.R.).
    Previous NBDPS (National Birth Defects Prevention Study) findings from 1997 to 2003 suggested that maternal antihypertensive use was associated with congenital heart defects (CHDs). We re-examined associations between specific antihypertensive medication classes and specific CHDs with additional NBDPS data from 2004 to 2011. After excluding mothers missing hypertension information or who reported pregestational diabetes mellitus, a multiple birth, or antihypertensive use but no hypertension, we compared self-reported maternal exposure data on 10 625 CHD cases and 11 137 nonmalformed controls. Read More

    Echocardiographic assessment of pediatric semilunar valve disease.
    Echocardiography 2017 Mar 31. Epub 2017 Mar 31.
    University of Nebraska Medical Center, Children's Hospital and Medical Center, Omaha, NE, USA.
    We reviewed echocardiography literature for the assessment and management of semilunar valve disease in children. A search was performed within the National Library of Medicine using the keywords aortic stenosis (AS), aortic regurgitation, pulmonary stenosis (PS), and pulmonary regurgitation in children. The search was further refined adding the keywords-pediatric, neonates, echocardiographic definition, classification, evaluation. Read More

    Regional right ventricular remodeling and function in children with idiopathic pulmonary arterial hypertension vs those with pulmonary valve stenosis: Insights into mechanics of right ventricular dysfunction.
    Echocardiography 2017 Apr 1. Epub 2017 Apr 1.
    Department of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, Toronto, ON, Canada.
    Background: Right ventricular (RV) pressure overload in the context of pulmonary stenosis (PS) has a much better prognosis than in the context of idiopathic pulmonary arterial hypertension (iPAH), which may be related to differences in global and regional RV remodeling and systolic function. We compared RV mechanics in children with PS to those with iPAH, aiming to identify mechanisms and markers of RV dysfunction.

    Methods: Eighteen controls, 18 iPAH and 16 PS patients were retrospectively studied. Read More

    Transthoracic Device Closure of Juxtaarterial Ventricular Septal Defects: Midterm Follow-Up Results.
    Ann Thorac Surg 2017 Mar 30. Epub 2017 Mar 30.
    Cardiothoracic Department, People's Hospital of Rizhao, Rizhao, Shandong, China.
    Background: In recent years, minimally invasive transthoracic device closure has been introduced as an alternative treatment option for selected patients with juxtaarterial ventricular septal defects. This study evaluated the midterm safety and efficacy of using device closure in selected patients.

    Methods: Between January 2008 and December 2014, 25 patients with juxtaarterial ventricular septal defects who met the inclusion criteria were enrolled in this study. Read More

    Repair of Atrioventricular Septal Defect and Transposition in Left Isomerism.
    Ann Thorac Surg 2017 Apr;103(4):e353-e355
    Department of Cardiovascular Surgery, Chiba Children's Hospital, Chiba, Japan.
    We report the successful primary anatomic correction of an atrioventricular septal defect with transposition of the great arteries and pulmonary stenosis in a 4-year-old girl with left isomerism by common atrioventricular valve division, Mustard-type atrial septation, and a Rastelli operation with ventricular septal defect enlargement. To the best of our knowledge, this is the first report of total correction for this combination of cardiac anomalies. Read More

    Early outcomes in patients undergoing transcatheter versus surgical pulmonary valve replacement.
    Heart 2017 Mar 28. Epub 2017 Mar 28.
    Department of Surgery, Phoenix Children's Hospital, Arizona, Phoenix, USA.
    Objectives: To identify predictors of morbidity and mortality in patients undergoing either transcatheter pulmonary valve replacement (TPVR) or surgical pulmonary valve replacement (SPVR) in an effort to quantify any early benefit of TPVR over SPVR.

    Methods: Using a risk-adjusted propensity score model, we compare early major morbidity and mortality between patients undergoing SPVR and TPVR at our institution between January 2006 and January 2014.

    Results: 145 patients in the SPVR cohort and 78 patients in the TPVR cohort were included. Read More

    Expanding the cardiac spectrum of Noonan syndrome with RIT1 variant: Left main coronary artery atresia causing sudden death.
    Eur J Med Genet 2017 Jun 25;60(6):299-302. Epub 2017 Mar 25.
    Service de Génétique, CHU-Hôpital Nord, Saint-Etienne, France. Electronic address:
    Noonan syndrome is a well-known genetic condition associating congenital heart defects, short stature, and distinctive facial features. Pulmonary valve stenosis and hypertrophic cardiomyopathy are the most frequent cardiac abnormalities, the latter being associated with a higher mortality. Here we report for the first time, a case of congenital left main coronary artery atresia in a Noonan syndrome associated with RIT1 variant, leading to unrescued sudden death. Read More

    Dehiscence of a pulmonary bioprosthesis with a focal dissection of the pulmonary artery in a patient with congenital pulmonic stenosis.
    Echocardiography 2017 May 27;34(5):776-778. Epub 2017 Mar 27.
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Pulmonary valve replacement (PVR) is the most common adult congenital cardiac operation performed. Valve degeneration leading to prosthetic stenosis and/or regurgitation is a long-term risk in this population and may be associated with paravalvular leak (PVL). Complications involving the proximal pulmonary artery, including dissection, are less clearly defined. Read More

    ANP and BNP plasma levels in patients with rheumatic mitral stenosis after percutaneous balloon mitral valvuloplasty.
    Postepy Kardiol Interwencyjnej 2017 10;13(1):18-25. Epub 2017 Mar 10.
    Department of Cardiomyopathies, Institute of Cardiology, Warsaw, Poland.
    Introduction: Atrial (ANP) and B-type (BNP) natriuretic peptides are hormones secreted by the heart as a response to volume expansion and pressure overload.

    Aim: To assess the changes of ANP and BNP after percutaneous balloon mitral valvuloplasty (PBMV) and to investigate factors associated with endpoints.

    Material And Methods: The study included 96 patients (90. Read More

    Treatment of severe refractory valvar pulmonary stenosis with primary transcatheter pulmonary valve implantation.
    Cardiol Young 2017 Mar 23:1-3. Epub 2017 Mar 23.
    2Department of Pediatric Cardiology, Royal Brompton Hospital,London,United Kingdom.
    Some patients with pulmonary valve stenosis do not respond to balloon valvuloplasty and must undergo surgical repair. We report the case of a 12-year-old child with pulmonary valve stenosis and Noonan syndrome in whom we performed transcatheter Melody pulmonary valve implantation after balloon dilation failed. The result was excellent. Read More

    Cardiac Function After Tetralogy of Fallot/Complete Atrioventricular Canal Repair.
    World J Pediatr Congenit Heart Surg 2017 Mar;8(2):189-195
    1 Division of Cardiac, Thoracic, and Vascular Surgery, Columbia University Medical Center, New York, NY, USA.
    Background: Repair of complete atrioventricular canal (CAVC) with tetralogy of Fallot (TOF) is a challenging operation increasingly being performed as a complete, primary repair in infancy. Previous studies have focused on perioperative outcomes; however, midterm valve function, ventricular function, and residual obstruction have received little attention.

    Methods: We retrospectively reviewed 20 patients who underwent CAVC/TOF repair (January 2005 to December 2014). Read More

    Isolated severe leftward displacement of the septum primum: anatomic and 3D echocardiographic findings and surgical repair.
    Interact Cardiovasc Thorac Surg 2017 May;24(5):772-777
    Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
    Objectives: Leftward displacement of the septum primum is usually described as associated with hypoplastic left heart syndrome or visceral heterotaxy. This rare malformation results in partially or totally anomalous pulmonary venous drainage with a normal connection of the pulmonary veins to the left atrium, depending on the degree of septal shift. We report the 3D echocardiographic and anatomic findings as well as the surgical repair in a series of isolated severe leftward displacement of the septum primum, responsible for totally anomalous pulmonary venous drainage. Read More

    Speculative Considerations about Some Cardiology Enigmas.
    Curr Cardiol Rev 2017 Mar 17. Epub 2017 Mar 17.
    Ribeirão Preto School of Medicine, University of São Paulo - Medicine Ribeirao Preto, SP. Brazil.
    Write a review text or point-of-view that takes into account the interests, if not of all, but of most readers of a scientific journal is an arduous task. The editorial can be grounded in published articles, even in a single article of undeniable importance and, it can also represent a trend of specialty. Therefore, especially for the sake of the reader's motivation, the present text was freely designed to discuss some cardiology enigmas in the context of the heart valve and coronary artery disease (CAD). Read More

    Anchor balloon, buddy wire, and wire and sheath techniques to deploy percutaneous pulmonary valves in tetralogy of fallot patients.
    Catheter Cardiovasc Interv 2017 Mar 17. Epub 2017 Mar 17.
    Division of Congenital and Structural Heart, Department of Pediatrics, Medical College of Georgia at Augusta University, Augusta, Georgia.
    Advances in surgical techniques in tetralogy of Fallot (TOF) patients have improved survival of these patients into adulthood. The procedure requires right ventricular outflow tract or trans-annular patch with resultant pulmonary stenosis and/or regurgitation. As such, adult patients seen with this condition may have increasing right ventricular hypertrophy and/or right ventricular dilation. Read More

    Comparison of MR flow quantification in peripheral and main pulmonary arteries in patients after right ventricular outflow tract surgery: A retrospective study.
    J Magn Reson Imaging 2017 Mar 16. Epub 2017 Mar 16.
    Department of Paediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München an der Technischen Universität München, Munich, Germany.
    Purpose: To compare the quantification of pulmonary stroke volume (SV) by phase contrast magnetic resonance (PC-MR) in the main pulmonary artery (MPA) to the sum of SVs in both peripheral pulmonary arteries (PPA) in different right ventricular (RV) outflow pathologies.

    Materials And Methods: Pulmonary SV was determined by PC-MR in the MPA and the PPA in healthy individuals (H, n = 54), patients after correction for tetralogy of Fallot with significant pulmonary regurgitation and without pulmonary or RV outflow tract stenosis (PR, n = 50), and in patients with RV outflow tract or pulmonary valve stenosis (PS, n = 50). Resulting SVs were compared to aortic SV in the ascending aorta. Read More

    First report of a simultaneous transcatheter mitral valve-in-valve and aortic valve replacement in a left ventricular assist device patient.
    Catheter Cardiovasc Interv 2017 Mar 15. Epub 2017 Mar 15.
    Piedmont Heart Institute and Marcus Heart Valve Center, Atlanta, Georgia.
    Transcatheter aortic valve replacement is standard of care for patients with severe aortic stenosis at high risk for surgical aortic valve replacement. Although not intended for treatment of primary aortic insufficiency, several transcatheter aortic valve prostheses have been used to treat patients with severe aortic insufficiency (AI), including patients with left ventricular assist devices (LVAD), in whom significant AI is not uncommon. Similarly, transcatheter valve replacements have been used for valve-in-valve treatment, in the pulmonary, aortic, and mitral positions, either via a retrograde femoral approach or antegrade transseptal approach (mitral valve-in-valve). Read More

    Biventricular impact of mild to moderate pulmonary valve stenosis in fetal life.
    Ultrasound Obstet Gynecol 2017 Mar 10. Epub 2017 Mar 10.
    Fetal i + D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
    Objectives: to define the pattern of fetal echocardiographic changes associated with isolated pulmonary valve stenosis (PS) and to correlate the echocardiographic findings with the neonatal outcome and the need of postnatal pulmonary valvuloplasty within the first 12 months of life.

    Methods: a prospective cohort study was designed on 16 fetuses with isolated PS and 48 controls matched by gestational age at scan (+/- 2 weeks). Fetal standard ultrasound and comprehensive echocardiography, which included cardiovascular morphometric parameters, systolic and diastolic functional and timing-measurements, were performed in all cases. Read More

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