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    12863 results match your criteria Pulmonic Valvular Stenosis

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    Impact of right ventricular function on outcome of severe aortic stenosis patients undergoing transcatheter aortic valve replacement.
    Am Heart J 2017 Feb 29;184:141-147. Epub 2016 Oct 29.
    Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC. Electronic address:
    Background: Right ventricular (RV) dysfunction was shown to be associated with adverse outcomes in a variety of cardiac patients and is considered a risk factor for adverse outcome according to the updated Valve Academic Research Consortium criteria.

    Objective: Our goal was to assess the impact of RV function at baseline on 1-year mortality among patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR).

    Methods: All patients with severe AS treated with TAVR from May 2007 to March 2015 at our center were included in the present study, and baseline and procedural characteristics were recorded for each patient. Read More

    Impact of Pulmonary Hypertension on Outcome in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction.
    Clin Res Cardiol 2017 Feb 14. Epub 2017 Feb 14.
    Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
    Aims: The prognostic impact of elevated pulmonary arterial pressure (PAP) remains controversial in aortic stenosis (AS) and few studies focused on patients with preserved left ventricular ejection fraction (LVEF). We aimed to investigate the impact of pulmonary hypertension (PH), invasively derived, on survival in severe AS with preserved LVEF.

    Methods And Results: Between 2000 and 2010, 749 patients (74 ± 8 years, 57% males) with preserved LVEF and severe AS without other valvular heart disease underwent cardiac catheterization. Read More

    Outcomes Following Melody Transcatheter Pulmonary Valve Implantation for Right Ventricular Outflow Tract Dysfunction in Repaired Congenital Heart Disease: First Reported Australian Single Centre Experience.
    Heart Lung Circ 2017 Jan 24. Epub 2017 Jan 24.
    Heart & Lung Institute, The Prince Charles Hospital, Brisbane, Qld, Australia; University of Queensland, Brisbane, Qld, Australia.
    Background: Transcatheter pulmonary valve implantation (TPVI) with the Melody® transcatheter pulmonary valve (TPV) has demonstrated good haemodynamic and clinical outcomes in the treatment of right ventricular outflow tract (RVOT) conduit dysfunction in patients with repaired congenital heart disease CHD. We present the first Australian single centre experience of patients treated with Melody TPV.

    Method: A prospective, observational registry was developed to monitor clinical and haemodynamic outcomes in patients with RVOT dysfunction treated with the Melody TPV (Medtronic Inc, Minneapolis, United States). Read More

    [L-shaped Partial Upper Sternotomy Approach for Aortic Valve Replacement].
    Kyobu Geka 2017 Feb;70(2):83-90
    Department of Cardiovascular Surgery, Okinawa Prefectural Nambu Medical Center and Children's Medical Center, Okinawa, Japan.
    Transcatheter aortic valve implantation is a recent innovation in the treatment of severe aortic stenosis. On the other hand, several reports suggested that minimally invasive aortic valve replacement (MICS-AVR) is likely to be associated with reduced postoperative discomfort and faster recovery. Of note, an upper partial sternotomy for isolated aortic valve replacement( L-shaped MICS-AVR) has been accepted as the most common approach to the MICS-AVR. Read More

    Mechanism of valve failure and efficacy of reintervention through catheterization in patients with bioprosthetic valves in the pulmonary position.
    Ann Pediatr Cardiol 2017 Jan-Apr;10(1):11-17
    Department of Cardiology, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.
    Background: Surgical and transcatheter bioprosthetic valves (BPVs) in the pulmonary position in patients with congenital heart disease may ultimately fail and undergo transcatheter reintervention. Angiographic assessment of the mechanism of BPV failure has not been previously described.

    Aims: The aim of this study was to determine the mode of BPV failure (stenosis/regurgitation) requiring transcatheter reintervention and to describe the angiographic characteristics of the failed BPVs and report the types and efficacy of reinterventions. Read More

    Stenting of critical tracheal stenosis with adjuvant cardio-pulmonary bypass.
    Lung India 2017 Jan-Feb;34(1):79-81
    Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma, USA.
    Severe and critical central airway obstruction causing impaired ventilation and/or oxygenation can impose tremendous challenges on the interventional pulmonologist. Near total airway obstruction can rapidly evolve into potentially fatal complete airway occlusion during bronchoscopic airway manipulation under moderate sedation; as well as during the induction of the general anesthesia. Although there are currently interventional pulmonary procedures available to tackle the critical airway obstruction in extreme situations, cardio-pulmonary bypass should be considered prior to the intervention to maintain the adequate gas exchange during the procedure. Read More

    Impact of Mitral Annular Displacement on Left Ventricular Diastolic Function Improvement After Transcatheter Aortic Valve Implantation.
    Circ J 2017 Jan 27. Epub 2017 Jan 27.
    Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center.
    Background: The clinical significance of left ventricular (LV) diastolic function (DF) improvement after transcatheter aortic valve implantation (TAVI) is not fully elucidated. We sought to investigate the long-term clinical and hemodynamic effects of post-TAVI DF improvement and to identify its determinants.Methods and Results:Clinical and serial echocardiographic data before and after TAVI were retrospectively reviewed together with measurement of mitral annular displacement (MAD) representing longitudinal myocardial function in 98 patients with severe aortic stenosis and ejection fraction >55%. Read More

    [Stress echocardiography and its central role in cardiac diagnostics].
    Herz 2017 Jan 27. Epub 2017 Jan 27.
    Dept. Cardiology Hagen, Faculty of Health, School of Medicine, University Witten-Herdecke, Elberfelder Str. 1, 58095, Hagen, Deutschland.
    Stress echocardiography (SE) has an established central role as a diagnostic tool in cardiology. It is not only an established method for the diagnostic and prognostic stratification of patients with coronary artery disease but also shows an emerging value for assessment of cardiac function beyond coronary artery disease. The enormous conceptual technological development of ultrasound technology (Doppler, digitizing, tissue Doppler imaging, strain technology, 3‑D-echo and new ultrasound contrast agents) has led to applications of SE in almost all diagnostic fields of cardiology. Read More

    Subclinical Right Ventricular Dysfunction in Patients with Severe Aortic Stenosis: A Retrospective Case Series.
    Cardiol Ther 2017 Jan 25. Epub 2017 Jan 25.
    Cardiovascular Medicine Division, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
    Introduction: There is scarce information about right ventricle (RV) function in patients with secondary pulmonary hypertension (PH) undergoing transcatheter aortic valve implantation (TAVI). We aim to identify possible RV abnormalities in patients referred for TAVI with severe aortic stenosis (sAS) and secondary PH.

    Methods: Objective measures of RV function, as well as noninvasive estimates of pulmonary artery systolic pressures (PASP) were obtained from 30 sAS patients undergoing percutaneous valve intervention. Read More

    Predictors of early restenosis after intracardiac echocardiography guided antegrade balloon aortic valvuloplasty in high-risk or inoperable patients.
    Cardiovasc Interv Ther 2017 Jan 20. Epub 2017 Jan 20.
    Division of Cardiology, Tokushima Red Cross Hospital, Irinokuchi103, Komatsushima-cho, Komatsushima, 773-8502, Japan.
    Antegrade balloon aortic valvuloplasty (BAV) may be more effective than retrograde BAV. However, early restenosis is found inconstantly within three months after BAV. To evaluate the factor of ER after intracardiac echocardiogram (ICE) guided Antegrade BAV, fifty patients with severe aortic stenosis (AS) underwent BAV procedures with ICE. Read More

    Simultaneous transfemoral aortic and transseptal mitral valve replacement utilising SAPIEN 3 valves in native aortic and mitral valves.
    EuroIntervention 2017 Jan;12(13):1649-1652
    University of Iowa Carver College of Medicine, Iowa City, IA, USA.
    Aims: Concomitant severe calcific aortic and mitral stenosis is a relatively uncommon but very challenging valvular heart disease to manage. We sought to evaluate the feasibility of a fully percutaneous approach to replace both stenotic native mitral and aortic valves using SAPIEN 3 valves.

    Methods And Results: An 87-year-old woman with chronic kidney disease stage 3, pul-monary hypertension, chronic obstructive pulmonary disease, a permanent pacemaker, and atrial fibrillation was referred with Class III heart failure symptoms. Read More

    SOURCE 3 Registry: Design and 30-Day Results of the European Post Approval Registry of the Latest Generation of the Sapien 3TM Transcatheter Heart Valve.
    Circulation 2017 Jan 19. Epub 2017 Jan 19.
    Hopital Bichat, Paris, France.
    Background: -The SOURCE 3 Registry is a European multicentre, observational registry of the latest generation of transcatheter heart valve, the SAPIEN 3(TM) (Edwards Lifesciences, Irvine, CA/USA). Its purpose is to document outcomes of clinical safety and performance after European approval was given.

    Methods: -In this manuscript we present the 30-day outcome of the SOURCE 3 Registry. Read More

    The change in NT-Pro-BNP and post-PTMC echocardiography parameters in patients with mitral stenosis. A pilot study.
    Rom J Intern Med 2017 Jan 18. Epub 2017 Jan 18.
    Background: The change in the level of NT-Pro-BNP (N-terminal Pro-Brain Natriuretic Peptide) is now considered as a reflection of the hemodynamic alterations and its circulatory reductions reported early after successful PTMC (percutaneous transvenous mitral commissurotomy). The present study aims to assess the change in the level of NT-Pro BNP following PTMC in patients with mitral stenosis and also to determine the association between circulatory NT-Pro BNP reduction and post-PTMC echocardiography parameters.

    Methods: Twenty five symptomatic consecutive patients with severe MS undergoing elective PTMC were prospectively enrolled. Read More

    At what age should tetralogy of Fallot be corrected?
    Cardiol Young 2017 Jan 12:1-5. Epub 2017 Jan 12.
    Department of Pediatrics,University of California,San Francisco,California,United States of America.
    Tetralogy of Fallot can be corrected with very low mortality at any age, even in neonates, but this does not necessarily mean that it should be corrected in the neonatal period. Although there are many advantages to early correction, a high proportion of these neonates have residual stenosis or pulmonary regurgitation that impairs ventricular function and may require further surgery or implantation of a pulmonary valve. Before we had the ability to correct this anomaly with low mortality in small children, a variety of palliative procedures had to be performed. Read More

    Mitral valve resistance determines hemodynamic consequences of severe rheumatic mitral stenosis and immediate outcomes of percutaneous valvuloplasty.
    Echocardiography 2017 Jan 10. Epub 2017 Jan 10.
    Department of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
    Introduction: The mitral valve area (MVA) poorly reflects the hemodynamic status of (MS). In this study, we compared the MVA with mitral valve resistance (MVR) with regard to the determination of hemodynamic consequences of MS and the immediate outcomes of percutaneous balloon mitral valvuloplasty (PBMV).

    Methods: In a prospective study, 36 patients with severe rheumatic MS with left ventricular ejection fraction (LVEF) >50% were evaluated. Read More

    Cardiovascular Abnormalities in Egyptian Children with Mucopolysaccharidoses.
    J Clin Diagn Res 2016 Nov 1;10(11):SC05-SC08. Epub 2016 Nov 1.
    Researcher, Department of Paediatrics, National Research Center , Cairo, Egypt .
    Introduction: The Mucopolysaccharidoses (MPS) are rare inherited metabolic disorders. They are characterized by the progressive systemic deposition of Glycosaminoglycans (GAGs). GAGs accumulate in the myocardium and the cardiac valves. Read More

    Pulmonary homograft stenosis in the Ross procedure: Incidence, clinical impact and predictors in long-term follow-up.
    Arch Cardiovasc Dis 2016 Dec 30. Epub 2016 Dec 30.
    Department of Cardiology, Reina Sofia University Hospital, Córdoba, Spain.
    Background: The Ross procedure is used in the treatment of selected patients with aortic valve disease. Pulmonary graft stenosis can appear in the long-term follow-up after the Ross intervention, but the factors involved and its clinical implications are not fully known.

    Aim: To describe the incidence, clinical impact and predictors of homograft stenosis and reintervention after the Ross procedure in a prospective series in a tertiary referral hospital. Read More

    [Ebstein's "like" anomaly ventricular double inlet. A rare association].
    Arch Cardiol Mex 2017 Jan - Mar;87(1):72-78. Epub 2016 Dec 30.
    Escuela Superior de Medicina Instituto Politécnico Nacional, Ciudad de México, México.
    Introduction And Objectives: The association of univentricular heart with double inlet and Ebstein's "like" anomaly of the common atrioventricular valve is extremely rare.

    Methods: Two hearts with this association are described with the segmental sequential system which determine the atrial situs, the types of atrioventricular and ventriculoarterial connections and associated anomalies.

    Results: Both hearts had atrial situs solitus, and a univentricular heart with common atrioventricular valve, a foramen primum and double outlet ventricle with normal crossed great arteries. Read More

    Single-Center Experience With the Senning Procedure in the Current Era.
    Semin Thorac Cardiovasc Surg 2016 Summer;28(2):514-520. Epub 2016 Jan 8.
    Department of Cardiothoracic Surgery, Children's Medical Center, Dallas, Division of Pediatric Cardiothoracic Surgery, University of Texas Southwestern Medical Center, Texas. Electronic address:
    The Senning procedure is an operative technique for atrial inversion in congenital heart anomalies. We sought to evaluate our contemporary outcomes employing this technique. A retrospective analysis of all patients who underwent the Senning procedure at our institution was performed. Read More

    Right Ventricular Outflow Tract Reconstruction With a Polytetrafluoroethylene Monocusp Valve: A 20-Year Experience.
    Semin Thorac Cardiovasc Surg 2016 Summer;28(2):463-470. Epub 2016 Jun 2.
    Section of Cardiothoracic Surgery, Department of Surgery, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:
    In patients with tetralogy of Fallot (TOF), pulmonary atresia (PA), and other congenital right ventricular outflow tract (RVOT) malformations, polytetrafluoroethylene (PTFE) monocusp outflow tract patches (MOTP) relieve obstruction and provide pulmonary valve competence. The purpose of this study was to determine whether our PTFE-MOTP was an acceptable short- and mid-term remedy for patients with TOF or PA as assessed by freedom from severe pulmonary regurgitation and freedom from reoperation. From 1994-2014, 171 patients (mean age 1. Read More

    Porcine Intestinal Submucosa (CorMatrix) for Semilunar Valve Repair in Children: A Word of Caution After Midterm Results.
    Semin Thorac Cardiovasc Surg 2016 Summer;28(2):436-445. Epub 2016 Jun 1.
    Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac Thoracic and Vascular Sciences, School of Medicine, University of Padova, Padova, Italy.
    Surgery for congenital valve anomalies in children is a challenging topic. We aim to assess early and late functional outcomes of CorMatrix scaffold after repair of aortic and pulmonary valves (PV) in congenital heart disease in a prospective nonrandomized clinical study on children with congenital aortic (Group 1) or PV (Group 2) disease. Primary endpoints were reoperation or reintervention on semilunar valves and echocardiographic evidence of regurgitation or stenosis greater than mild. Read More

    [Interventional cardiac catheterization in congenital heart disease].
    Presse Med 2016 Dec 27. Epub 2016 Dec 27.
    CHRU de Lille, hôpital Cardiologique, université Lille Nord de France, faculté de médicine, service des maladies cardiovasculaires infantiles et congénitales, boulevard Pr.-Leclercq, 59037 Lille cedex, France.
    Interventional cardiac catheterization has a major place in the management of congenital heart disease. Since the Rashkind atrioseptostomy in mid-1960s, many techniques have been developed. For some, it is necessary to close a cardiac or extracardiac shunt using occluder (double disc system, plug, coil…): closure of atrial septal defect, ventricular septal defect or patent arterial duct. Read More

    Pulmonary and tricuspid valvuloplasty in carcinoid heart disease.
    Catheter Cardiovasc Interv 2016 Dec 28. Epub 2016 Dec 28.
    Division of Pediatric Cardiology, Congenital Heart Center, University of Florida, Gainesville, Florida.
    A 26-year-old female with carcinoid heart disease consisting of severe pulmonary and tricuspid valve stenosis was admitted with line associated sepsis. She recovered from sepsis with antibiotics and aggressive fluid resuscitation but became grossly volume overloaded with evidence of tense ascites and lower extremity edema. She developed worsening renal and hepatic function due to congestive nephropathy and hepatopathy, which did not respond to intravenous diuretics, and she was deemed too sick for surgical pulmonary and tricuspid valve replacement. Read More

    20 years experience with the Ross operation in middle-aged patients: the autologous principle is still alive.
    Interact Cardiovasc Thorac Surg 2016 Dec 25. Epub 2016 Dec 25.
    Department of Cardiovascular Surgery, Santa Casa de Curitiba, PUCPR, Curitiba, Paraná, Brazil.
    Objectives: Review our long-term results with the Ross operation in middle-aged patients.

    Methods: Between 1995 and 2016, 129 consecutive patients (106 males); mean age (47.2 ± 5. Read More

    Rare copy number variants in a population-based investigation of hypoplastic right heart syndrome.
    Birth Defects Res A Clin Mol Teratol 2016 Dec 23. Epub 2016 Dec 23.
    Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
    Background: Hypoplastic right heart syndrome (HRHS) is a rare congenital defect characterized by underdevelopment of the right heart structures commonly accompanied by an atrial septal defect. Familial HRHS reports suggest genetic factor involvement. We examined the role of copy number variants (CNVs) in HRHS. Read More

    Pulmonary Artery Dissection: A Case Treated by Homograft Replacement.
    Ann Thorac Surg 2017 Jan;103(1):e47-e49
    Department of Thoracic and Cardiovascular Surgery, University Hospital Group Henri Mondor, APHP, Paris-Est Créteil University, Créteil, France.
    Pulmonary artery dissection was diagnosed in a 32-year-old man who was admitted to the emergency department with intense chest pain. He had a history of pulmonary balloon valvuloplasty for congenital pulmonary stenosis at the age of 7 and no pulmonary hypertension. The operation was performed with cardiopulmonary bypass. Read More

    Valve-Sparing or Valve Reconstruction Options in Tetralogy of Fallot Surgery.
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2017 Jan;20:79-83
    Columbia University College of Physicians and Surgeons, Congenital and Pediatric Cardiac Surgery, New York, NY; and New York-Presbyterian Morgan Stanley Children's Hospital (CHONY), New York, NY. Electronic address:
    This review deals with a relatively new field in congenital heart surgery, valve preservation or, in cases of more severe pulmonary valve stenosis or dysplasia, valve reconstruction during tetralogy of Fallot repair. We describe the stepwise approach utilized, starting with simple maneuvers such as commissurotomy and valve dilation for mild pulmonary stenosis to commissurotomy and intraoperative balloon dilation for moderate stenosis, and finally transection of the annulus and valve reconstruction using a patch that acts as a modified monocusp. Results are presented and have been gratifying. Read More

    The failing right heart: implications and evolution in high-risk patients undergoing transcatheter aortic valve implantation.
    EuroIntervention 2016 Dec;12(12):1542-1549
    Department of Cardiology, IRCCS Pol San Donato, San Donato Milanese, Milan, Italy.
    Aims: Right ventricular dysfunction (RVdy) is negatively associated with survival after left heart valve surgery. It is unclear whether RVdy has the same impact in patients undergoing transcatheter aortic valve implantation (TAVI). We sought to evaluate the prognostic impact of different grades of RVdy on TAVI, with and without concomitant left ventricular dysfunction (LVdy), and the possible impact of TAVI on RVdy. Read More

    The Relationship Between Hemodialysis and the Echocardiographic Findings in Patients with Chronic Kidney Disease.
    Med Arch 2016 Oct 25;70(5):328-331. Epub 2016 Oct 25.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: The incidence of cardiac morbidity and mortality is high in patients treated with hemodialysis (HD). The aim of this study was to evaluate the relationship between HD and the echocardiographic findings in patients with chronic kidney disease (CKD).

    Methods: Between 2012 and 2014, 150 patients with CKD. Read More

    Acute Invasive Hemodynamic Effects of Transcatheter Aortic Valve Replacement.
    J Heart Valve Dis 2016 Mar;25(2):162-172
    Department of Transcatheter Heart Valves, HYGEIA Hospital, Athens.
    Background: Aortic stenosis imposes a chronic pressure overload on the left ventricle, with attendant adaptations in hemodynamics, muscle mass and performance. The hemodynamic changes that occur during the initial 24 h following abrupt removal of the impediment to left ventricular outflow have not been previously examined.

    Methods: A total of 52 patients with right heart catheterization was evaluated before, within 6 h and at 24 h after successful transcatheter aortic valve replacement (TAVR). Read More

    Percutaneous balloon valvuloplasty in carcinoid pulmonary valve stenosis.
    Catheter Cardiovasc Interv 2016 Dec 13;88(7):1174-1176. Epub 2015 Nov 13.
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
    More than half of patients with carcinoid syndrome develop carcinoid valve disease. Both the tricuspid and pulmonary valve are often involved. Symptoms of carcinoid syndrome with flushing, diarrhea, and bronchospasm often precedes cardiac symptoms. Read More

    Three dimensional rotational angiography for assessment of coronary arteries during melody valve implantation: introducing a technique that may improve outcomes.
    Neth Heart J 2017 Feb;25(2):82-90
    Rady Children's Hospital, San Diego, University of California, San Diego, USA.
    Background: Adverse events from Melody valve implantation may be catastrophic. To date a role for three dimensional rotational angiography of the aortic root (3DRAA) during Melody valve implantation has not been established.

    Objectives: To describe the role of 3DRAA in the assessment of Melody valve candidacy and to demonstrate that it may improve outcomes. Read More

    Maternal and fetal outcomes in pregnant women undergoing balloon mitral valvotomy for rheumatic mitral stenosis.
    Indian Heart J 2016 Nov - Dec;68(6):780-782. Epub 2016 May 20.
    Department of Cardiology, Government Medical College, Kozhikode, Kerala, India.
    Background: Rheumatic mitral stenosis constitutes a major cause of acquired heart disease complicating pregnancy in India. In the present study, we have studied the fetal and maternal outcomes of women undergoing balloon mitral valvotomy during pregnancy.

    Methods And Results: 49 pregnant ladies were included in this study in whom balloon mitral valvotomy was performed. Read More

    Pulmonary hypertension in rheumatic mitral stenosis revisited.
    Herz 2016 Dec 7. Epub 2016 Dec 7.
    Department of Anesthesiology, University at Buffalo, Buffalo, NY, USA.
    Background: In patients with mitral stenosis (MS), pulmonary hypertension (PH) is a significant contributor to the associated morbidity. We aimed to study factors associated with the presence of significant PH (sPH) and whether incorporating body surface area (BSA) in the mitral valve area (MVA) would improve the predictive value of the latter.

    Methods: The medical records of 558 patients with severe MS undergoing percutaneous balloon mitral commissurotomy were evaluated over a period of 8 years. Read More

    Pulmonary artery dissection following balloon valvuloplasty in a dog with pulmonic stenosis.
    J Vet Cardiol 2016 Nov 30. Epub 2016 Nov 30.
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr. Madison, WI 53706, USA. Electronic address:
    A 3-month-old, 9.9 kg, male pit bull cross was referred for evaluation of collapse. A left basilar systolic heart murmur graded V/VI and a grade IV/VI right basilar systolic heart murmur were ausculted. Read More

    [Impact of reduced left ventricular ejection fraction on all-cause mortality of 75 years old and over patients with moderate to severe aortic stenosis].
    Zhonghua Xin Xue Guan Bing Za Zhi 2016 Oct;44(10):854-861
    Department of Cardiology, Fuwai Hospital, National Cardiovascular Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
    Objective: To evaluate the impact of left ventricular systolic dysfunction on all-cause mortality of 75 years old and over patients with moderate to severe aortic stenosis. Methods: Clinical data of 301 consecutive aged (≥75 years old) patients with a diagnosis of non-rheumatic moderate to severe aortic stenosis by echocardiography between January 1, 2008 and January 1, 2015 in our hospital were retrospectively analyzed. According to the LVEF, patients were divided into normal LVEF subjects and low LVEF subjects, and the low LVEF level was set at below 60%(≤60%(n=171)vs. Read More

    Patterns and trends of transcatheter aortic valve implantation in Italy: insights from RISPEVA.
    J Cardiovasc Med (Hagerstown) 2017 Feb;18(2):96-102
    aUnità Operativa di Interventistica Cardiovascolare, Presidio Ospedaliero Pineta Grande, Castel Volturno, and Unità Operativa di Emodinamica, Casa di Salute Santa Lucia, San Giuseppe Vesuviano bDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, and Department of AngioCardioNeurology, IRCCS Neuromed, Pozzili cDivisione di Cardiologia, Fondazione Gabriele Monasterio, Massa dDivision of Cardiology, University of Pisa, Pisa eDivisione di Cardiologia, Azienda Ospedaliera di Siena, Siena fDivision of Interventional Cardiology, IRCCS Humanitas, Rozzano gDivision of Cardiology, San Giovanni di Dio e Ruggi D'Aragona Hospital, Salerno hCardiovascular, Respiratory, Nephrologic and Geriatric Sciences Department, Umberto I Hospital, Sapienza University of Rome, Rome iDivisione di Cardiologia, Centro Cardiologico Monzino, Milano jDivisione di Cardiologia, Azienda Ospedaliera di Trento, Trento kDivision of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro lUnità Operativa Complessa di Cardiologia Interventistica, Anthea Hospital, GVM Care & Research, Bari mDivision of Cardiology, Maria Pia Hospital, Torino nInterventional Cardiovascular Unit, Maria Cecilia Hospital, GVM Care and Research, Cotignola oDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
    Aims: Clinical trials have shown that transcatheter aortic valve implantation for aortic stenosis compares favorably to surgical replacement in high-risk patients and is superior to medical therapy in those at prohibitive risk. There is uncertainty however on patterns and trends in transcatheter aortic valve implantation, especially focusing on Italy.

    Methods: The RISPEVA study is a prospective Italian registry including 21 institutions. Read More

    Impact of postoperative duration of Aspirin use on longevity of bioprosthetic pulmonary valve in patients who underwent congenital heart disease repair.
    Korean J Pediatr 2016 Nov 18;59(11):446-450. Epub 2016 Nov 18.
    Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Bucheon, Korea.
    Purpose: Generally, aspirin is used as a protective agent against thrombogenic phenomenon after pulmonary valve replacement (PVR) using a bioprosthetic valve. However, the appropriate duration of aspirin use is unclear. We analyzed the impact of postoperative duration of aspirin use on the longevity of bioprosthetic pulmonary valves in patients who underwent repair for congenital heart diseases. Read More

    Association Between Left Atrial Dilatation and Invasive Hemodynamics at Rest and During Exercise in Asymptomatic Aortic Stenosis.
    Circ Cardiovasc Imaging 2016 Oct;9(10)
    From the Department of Cardiology, Odense University Hospital, Denmark (N.L.C., J.S.D., R.C.-S., R.B., E.V.S., L.V., J.E.M.); Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense (K.J.), and Department of Cardiology, Lillebaelt Hospital, Vejle, Denmark (F.H.S.).
    Background: Transition from an asymptomatic to symptomatic state in severe aortic stenosis is often difficult to assess. Identification of a morphological sign of increased hemodynamic load may be important in asymptomatic aortic stenosis to identify patients at risk.

    Methods And Results: Thirty-nine patients with asymptomatic severe aortic stenosis (aortic valve area <1 cm(2), peak jet velocity >3. Read More

    Melody valve implantation within freestyle stentless porcine aortic heterograft.
    Catheter Cardiovasc Interv 2016 Nov 26. Epub 2016 Nov 26.
    Cook Children's Medical Center, Fort Worth, Texas.
    Background: The Melody transcatheter pulmonary valve has been implanted successfully worldwide since its first implant in 2000. The vast majority of these valves have been implanted in pulmonary homografts. In our institution, the most common valve used for pulmonary valve replacement is the Medtronic Freestyle stentless porcine aortic heterograft. Read More

    Transaortic Edge-to-Edge Repair for Functional Mitral Regurgitation During Aortic Valve Replacement: A 13-Year Experience.
    Innovations (Phila) 2016 Nov/Dec;11(6):425-429
    From the *Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA; and †Division of Cardiology, Columbia University, Mount Sinai Heart Institute, Miami Beach, FL USA.
    Objective: The study evaluated the feasibility of a transaortic edge-to-edge mitral valve repair (Alfieri stitch) for moderate or greater (≥2+) functional mitral regurgitation (MR) in high-risk patients undergoing aortic valve replacement.

    Methods: We retrospectively evaluated 40 consecutive patients who underwent aortic valve replacement combined with a transaortic edge-to-edge mitral valve repair for 2+ or greater functional MR, between February 2002 and April 2015. The MR was graded semiquantitatively as 0 (trace/none), mild (1+), moderate (2+), or moderate to severe (3-4+). Read More

    Functional mitral stenosis following mitral valve repair.
    Curr Opin Cardiol 2017 Mar;32(2):161-165
    aDivision of Cardiac Surgery bSchool of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa cKeenan Research Centre for Biomedical Science dLi Ka Shing Knowledge Institute of St Michael's Hospital eDivision of Cardiac Surgery, St Michael's Hospital fDepartment of Surgery, University of Toronto, Toronto, Ontario, Canada.
    Purpose Of Review: This review summarizes the evidence describing functional mitral stenosis (MS) following surgical mitral valve repair.

    Recent Findings: Functional MS is an evolving concept and has been implicated in the repair of functional and organic mitral regurgitation. Following repair of functional mitral regurgitation, an elevation in peak transmitral gradient and pulmonary artery pressure has been observed under physiologic stress. Read More

    The concept of double inlet-double outlet right ventricle: a distinct congenital heart disease.
    Cardiovasc Pathol 2017 Jan - Feb;26:39-44. Epub 2016 Sep 25.
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Giustiniani 2, 35128, Padova, Italy. Electronic address:
    The aim of this study was to estimate the incidence and to analyze the anatomy of double inlet-double outlet right ventricle complex and its associated cardiac anomalies in our autopsy series. Among the 1640 hearts with congenital heart disease of our Anatomical Collection, we reviewed the specimens with double inlet-double outlet right ventricle, according to the sequential-segmental analysis, identifying associated cardiac anomalies and examining lung histology to assess the presence of pulmonary vascular disease. We identified 14 hearts with double inlet-double outlet right ventricle (0. Read More

    Mechanisms of Effort Intolerance in Patients With Rheumatic Mitral Stenosis: Combined Echocardiography and Cardiopulmonary Stress Protocol.
    JACC Cardiovasc Imaging 2016 Nov 10. Epub 2016 Nov 10.
    Division of Cardiovascular Diseases and Internal Medicine, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:
    Objectives: This study sought to evaluate mechanisms of effort intolerance in patients with rheumatic mitral stenosis (MS).

    Background: Combined stress echocardiography and cardiopulmonary testing allows assessment of cardiac function, hemodynamics, and oxygen extraction (A-Vo2 difference).

    Methods: Using semirecumbent bicycle exercise, 20 patients with rheumatic MS (valve area 1. Read More

    Percutaneous closure of isolated ostium secundum-type atrial septal defect in a patient with Mayer-Rokitansky-Küster-Hauser syndrome.
    Rev Port Cardiol 2016 Dec 16;35(12):701.e1-701.e3. Epub 2016 Nov 16.
    Department of Radiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
    Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital anomaly characterized by complete or partial aplasia of the uterus and the upper part of the vagina. It is reported to be associated with cardiovascular disorders including atrial septal defect, anomalous pulmonary venous return, aortopulmonary window, pulmonary valve stenosis, mitral valve prolapse, tetralogy of Fallot, truncus arteriosus, and patent ductus arteriosus. Herein, for the first time in the medical literature, we present percutaneous closure of an isolated ostium secundum atrial septal defect in this syndrome. Read More

    Positive predictive value of cardiovascular diagnoses in the Danish National Patient Registry: a validation study.
    BMJ Open 2016 Nov 18;6(11):e012832. Epub 2016 Nov 18.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
    Objective: The majority of cardiovascular diagnoses in the Danish National Patient Registry (DNPR) remain to be validated despite extensive use in epidemiological research. We therefore examined the positive predictive value (PPV) of cardiovascular diagnoses in the DNPR.

    Design: Population-based validation study. Read More

    Optimal C-arm angulation during transcatheter aortic valve replacement: Accuracy of a rotational C-arm computed tomography based three dimensional heart model.
    World J Cardiol 2016 Oct;8(10):606-614
    Verena Veulemans, Katharina Hellhammer, Tobias Zeus, Ralf Westenfeld, Malte Kelm, Jan Balzer, Department of Medicine, Division of Cardiology, Pulmonary Diseases, Vascular Medicine, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
    Aim: To investigate the accuracy of a rotational C-arm CT-based 3D heart model to predict an optimal C-arm configuration during transcatheter aortic valve replacement (TAVR).

    Methods: Rotational C-arm CT (RCT) under rapid ventricular pacing was performed in 57 consecutive patients with severe aortic stenosis as part of the pre-procedural cardiac catheterization. With prototype software each RCT data set was segmented using a 3D heart model. Read More

    Surgical Treatment for Double Outlet Right Ventricle With Pulmonary Outflow Tract Obstruction.
    World J Pediatr Congenit Heart Surg 2016 Nov;7(6):696-699
    Heart Center, The First Hospital of Tsinghua University, Beijing, China.
    Background: Double outlet right ventricle (DORV) is a conotruncal anomaly that is a defining element of many types of complex congenital heart disease. Because of a big variety of pathology, there are still some controversies with respect to the definition, classification, and surgical treatment. We report our experience with surgical treatment for DORV (as defined by the "90% rule") with pulmonary outflow tract obstruction (POTO). Read More

    Percutaneous management of failed bioprosthetic pulmonary valves in patients with congenital heart defects.
    J Cardiovasc Med (Hagerstown) 2016 Nov 8. Epub 2016 Nov 8.
    aPediatric and Adult Congenital Heart Centre, IRCCS, Policlinico San Donato, University Hospital, Via Morandi, 30, San Donato, Milan 20097, Italy bInstitute of Cardiology, Catholic University of the Sacred Heart, IRCCS Policlinico Universitario 'Agostino Gemelli', Rome, Italy.
    Aims: We reviewed our center experience in the field of transcatheter pulmonary valve-in-valve implantation (TPViV), that is emerging as a treatment option for patients with pulmonary bioprosthetic valve (BPV) dysfunction.

    Methods: Between April 2008 and September 2015, a total of six patients with congenital heart disease (four men) underwent TPViV due to stenosis of preexisting BPV. Four patients received a Melody Medtronic Transcatheter Pulmonary Valve and two an Edward Sapien Valve. Read More

    Long-Term Outcomes of Balloon Valvuloplasty for Isolated Pulmonary Valve Stenosis.
    Pediatr Cardiol 2016 Nov 8. Epub 2016 Nov 8.
    Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA.
    To evaluate the long-term cumulative incidence of ≥ moderate pulmonary regurgitation (PR) and re-intervention following balloon pulmonary valvuloplasty (BPV). While BPV for pulmonary valve stenosis (PS) relieves obstruction acutely, long-term outcomes are not well documented. Between 1982 and 2002, 211 patients had BPV for isolated PS. Read More

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