J Vis Exp 2022 Jun 8(184). Epub 2022 Jun 8.
Department of Pediatric Cardiology and Congenital Heart Disease, Charité University Medicine Berlin; Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Berlin; DZHK (German Centre for Cardiovascular Research) and BMBF (German Ministry of Education and Research); BIH (Berlin Institute of Health); BCRT (BIH Center of Regenerative Therapies);
Transcatheter pulmonary valve replacement has been established as a viable alternative approach for patients suffering from right ventricular outflow tract or bioprosthetic valve dysfunction, with excellent early and late clinical outcomes. However, clinical challenges such as stented heart valve deterioration, coronary occlusion, endocarditis, and other complications must be addressed for lifetime application, particularly in pediatric patients. To facilitate the development of a lifelong solution for patients, transcatheter autologous pulmonary valve replacement was performed in an adult sheep model. Read More