9,479 results match your criteria Pulmonic Regurgitation

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model.

J Vis Exp 2022 Jun 8(184). Epub 2022 Jun 8.

Department of Pediatric Cardiology and Congenital Heart Disease, Charité University Medicine Berlin; Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Berlin; DZHK (German Centre for Cardiovascular Research) and BMBF (German Ministry of Education and Research); BIH (Berlin Institute of Health); BCRT (BIH Center of Regenerative Therapies);

Transcatheter pulmonary valve replacement has been established as a viable alternative approach for patients suffering from right ventricular outflow tract or bioprosthetic valve dysfunction, with excellent early and late clinical outcomes. However, clinical challenges such as stented heart valve deterioration, coronary occlusion, endocarditis, and other complications must be addressed for lifetime application, particularly in pediatric patients. To facilitate the development of a lifelong solution for patients, transcatheter autologous pulmonary valve replacement was performed in an adult sheep model. Read More

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Pediatric Surgical Pulmonary Valve Replacement Outcomes After Implementation of a Clinical Pathway.

World J Pediatr Congenit Heart Surg 2022 Jul;13(4):420-425

Department of Pediatrics, Division of Cardiology, 23333Loma Linda University Children's Hospital, Loma Linda, CA, USA.

Background: Standardization of perioperative care can reduce resource utilization while improving patient outcomes. We sought to describe our outcomes after the implementation of a perioperative clinical pathway for pediatric patients undergoing elective surgical pulmonary valve replacement and compare these results to previously published national benchmarks.

Methods: A retrospective single-center descriptive study was conducted of all pediatric patients who underwent surgical pulmonary valve replacement from 2017 through 2020, after the implementation of a clinical pathway. Read More

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[Infective endocarditis in pregnancy: A case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Jun;54(3):578-580

Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing 100191, China.

Infective endocarditis in pregnancy is extremely rare in clinical practice. Guidelines addressing prophylaxis and management of infective endocarditis do not extensively deal with concomitant pregnancy, and case reports on infective endocarditis are scarce. Due to increased blood volume and hemodynamic changes in late pregnancy, endocardial neoplasms are easy to fall off and cause systemic or pulmonary embolism, respiratory, cardiac arrest and sudden death may occur in pregnant women, the fetus can suffer from intrauterine distress and stillbirth at any time, leading to adverse outcomes for pregnant women and fetuses. Read More

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Severe Functional Tricuspid Valve Regurgitation: Predictors of Mortality After Initial Diagnosis.

Heart Lung Circ 2022 Jun 3. Epub 2022 Jun 3.

National University Heart Centre, Singapore.

Background: Severe functional tricuspid regurgitation (fTR) is associated with adverse clinical outcomes and remains under-treated. There is recent interest in this disease due to emerging tricuspid valve therapies. However, the timing and selection of patients who may benefit from treatment is uncertain. Read More

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Prevalence and Natural History of Mitral Annulus Calcification and Related Valve Dysfunction.

Mayo Clin Proc 2022 Jun;97(6):1094-1107

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To evaluate the prevalence and natural history of mitral annulus calcification (MAC) and associated mitral valve dysfunction (MVD) in patients undergoing clinically indicated echocardiography.

Methods: A retrospective review was conducted of all adults who underwent echocardiography in 2015. Mitral valve dysfunction was defined as mitral regurgitation or mitral stenosis (MS) of moderate or greater severity. Read More

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Patch enlargement may not be a good strategy for treating tetralogy of Fallot with unbalanced pulmonary artery branches.

Eur J Cardiothorac Surg 2022 Jun;62(1)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine. 1678 Dongfang Road, Shanghai 200127, People's Republic of China.

Objectives: Our goal was to determine the optimal strategy for managing tetralogy of Fallot (TOF) with unbalanced pulmonary artery (PA) branches by investigating the different effects of PA plasty on the development of hypoplastic PA (HPA).

Methods: A single-centre, retrospective analysis was carried out to compare the outcome of different PA plasty methods on the development of HPA in patients with TOF with unbalanced PA branches. Size and balance of the PA branches were used to evaluate the outcome of PA plasty. Read More

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Mechanistic Insights into Tricuspid Regurgitation Secondary to Pulmonary Arterial Hypertension.

Am J Cardiol 2022 Jul 18;175:97-105. Epub 2022 May 18.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

The simultaneous presence of pulmonary arterial hypertension (PAH) and secondary tricuspid regurgitation (STR) portends particularly poor outcomes. However, not all patients with PAH develop significant STR, and the mechanisms and clinical implications underlying this phenomenon remain unclear. We sought to describe the functional, anatomic, hemodynamic, and clinical characteristics of patients with PAH with and without STR. Read More

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The added value of right ventricular function normalized for afterload to improve risk stratification of patients with pulmonary arterial hypertension.

PLoS One 2022 19;17(5):e0265059. Epub 2022 May 19.

Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, Belgium.

Background: Risk stratification is central to the management of pulmonary arterial hypertension (PAH). For this purpose, multiparametric tools have been developed, including the ESC/ERS risk score and its simplified versions derived from large database analysis such as the COMPERA and the French Pulmonary Hypertension Network (FPHN) registries. However, the distinction between high and intermediate-risk profiles may be difficult as the latter lacks granularity. Read More

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The accuracy and influencing factors of Doppler echocardiography in estimating pulmonary artery systolic pressure: comparison with right heart catheterization: a retrospective cross-sectional study.

BMC Med Imaging 2022 May 16;22(1):91. Epub 2022 May 16.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.

Background: Noninvasive assessment of pulmonary artery systolic pressure by Doppler echocardiography (sPAP) has been widely adopted to screen for pulmonary hypertension (PH), but there is still a high proportion of overestimation or underestimation of sPAP. We therefore aimed to explore the accuracy and influencing factors of sPAP with right heart catheterization (RHC) as a reference.

Methods: A total of 218 highly suspected PH patients who underwent RHC and echocardiography within 7 days were included. Read More

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Hand-sewn expanded polytetrafluoroethylene valved conduit for right ventricular outflow tract reconstruction.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Jan;47(1):94-100

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.

Objectives: Due to the lack of large-sized pulmonary valved conduit products in clinical practice, hand-sewn expanded polytetrafluoroethylene (ePTFE) valved conduit has been used for right ventricular outflow tract (RVOT) reconstruction in many heart centers around the world. This study aims to summarize the early results of the ePTFE valved conduit and the sewing technology of the conduit in combination with the latest progress, and to provide a reference for the application of ePTFE valved conduit.

Methods: A total of 21 patients using ePTFE valved conduit for RVOT reconstruction in the Second Xiangya Hospital, Central South University from October 2018 to October 2020 were prospectively enrolled in this study. Read More

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January 2022

Magnitude of mitral valve closure plays a pivotal role in enhancing the forward blood flow during cardiac massage in dogs with ventricular fibrillation.

J Vet Med Sci 2022 Jun 3;84(6):877-880. Epub 2022 May 3.

Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan.

Motion of mitral valve during cardiac massage was examined using beagle dogs with ventricular fibrillation (n=4). Active compression-decompression cardiac massage (ACD-CM) exhibited greater peak aortic pressure than standard cardiac massage (S-CM), reverse of which was true for peak pulmonary capillary wedge pressure in each animal. Accordingly, peak aortic pressure was greater than peak pulmonary capillary wedge pressure with ACD-CM, whereas its reverse was true with S-CM. Read More

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Response to acute vasodilator challenge and haemodynamic modifications after MitraClip in patients with functional mitral regurgitation and pulmonary hypertension.

Eur Heart J Acute Cardiovasc Care 2022 Jun;11(6):464-469

Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 1, 27100 Pavia, Italy.

The effectiveness of transcatheter edge-to-edge repair (TEER) in patients with functional mitral regurgitation (FMR) and pulmonary hypertension (PH) is still debated and pre-procedural predictors of haemodynamic improvement after TEER in this setting are currently unknown. We investigated whether normalization of pulmonary artery wedge pressure (PAWP) in response to sodium nitroprusside (SNP) during baseline right heart catheterization might be predictive of a favourable haemodynamic response to MitraClip in patients with FMR and PH. Among 22 patients enrolled, 13 had a positive response to SNP (responders), nine were non-responders. Read More

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Coronary Artery Compression in Percutaneous Pulmonary Valve Implantation: Go the Distance.

JACC Cardiovasc Interv 2022 May;15(9):989-991

Department of Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Leipzig, Germany.

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Comparison of serum biomarkers of myocardial fibrosis with cardiac magnetic resonance in patients operated for tetralogy of Fallot.

Int J Cardiol 2022 Jul 26;358:27-33. Epub 2022 Apr 26.

Division of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Background: Serum biomarkers of myocardial fibrosis are considered markers of adverse outcome in adults with heart disease. Associations between biomarkers and clinical parameters in tetralogy of Fallot (TOF) has been understudied. We compared serum biomarker profiles with clinical and cardiac magnetic resonance (CMR) parameters of ventricular remodeling in patients with repaired TOF. Read More

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Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management.

Circ Cardiovasc Interv 2022 May 29;15(5):e011664. Epub 2022 Apr 29.

Division of Pediatric Cardiology (H. El-Sabrout, P.G., K.R., G.V., J.P., S.H., H. El-Said), Rady Children's Hospital/University of California, San Diego.

Background: Neonatal myocardial infarction is rare and is associated with a high mortality of 40% to 50%. We report our experience with neonatal myocardial infarction, including presentation, management, outcomes, and our current patient management algorithm.

Methods: We reviewed all infants admitted with a diagnosis of coronary artery thrombosis, coronary ischemia, or myocardial infarction between January 2015 and May 2021. Read More

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Transcatheter mitral valve repair in patient with atrial functional mitral regurgitation using novel DragonFly™ device.

Catheter Cardiovasc Interv 2022 04 16;99(5):1691-1695. Epub 2022 Feb 16.

Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.

We report the first case of transcatheter mitral valve repair with the novel DragonFly™ device, a transcatheter edge-to-edge mitral regurgitation (MR) repair device, in a patient with severe, symptomatic MR due to annular dilation from atrial functional disease (Carpentier type I). The patient had experienced multiple heart failure events and was unsuitable for surgery due to pulmonary dysfunction and obesity. Read More

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Repair of a remote pericommissural anomalous left coronary artery from the pulmonary artery.

Multimed Man Cardiothorac Surg 2022 Apr 1;2022. Epub 2022 Apr 1.

Division of Congenital Cardiovascular Surgery, Children's Heart Centre and Children's Research Centre, University Children's Hospital Zürich, Switzerland.

We demonstrate a classic trapdoor technique to correct a late-presenting remote pericommissural anomalous left coronary artery from the pulmonary artery. The merits of the technique compared to alternative techniques are explained. The impact of late diagnosis on left ventricular function as well as on papillary muscle ischemia-induced mitral regurgitation is evident. Read More

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A rare congenital anomaly: Anomalous fibromuscular cord of the left atrium.

J Card Surg 2022 Jul 26;37(7):2107-2109. Epub 2022 Apr 26.

Department of Echocardiography, Wuhan Asia Heart Hospital, Wuhan, Hubei, P.R. China.

Background: Left atrial anomalous fibromuscular cord is a rare congenital anomaly, which exists in a small proportion of the general population. Although its clinical significance remains largely unknown, it is generally considered a benign entity. We report a case of incidental finding of left atrial fibromuscular cord without structural cardiac abnormalities or hemodynamic obstruction. Read More

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Incremental Prognosis by Left Atrial Functional Assessment: The Left Atrial Coupling Index in Patients With Floppy Mitral Valves.

J Am Heart Assoc 2022 May 26;11(9):e024814. Epub 2022 Apr 26.

Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Emerging data suggest important prognostic value to left atrial (LA) characteristics, but the independent impact of LA function on outcome remains unsubstantiated. Thus, we aimed to define the incremental prognostic value of LA coupling index (LACI), coupling volumetric and mechanical LA characteristics and calculated as the ratio of left atrial volume index to tissue Doppler imaging a', in a large cohort of patients with isolated floppy mitral valve. Methods and Results All consecutive 4792 patients (61±16 years, 48% women) with isolated floppy mitral valve in sinus rhythm diagnosed at Mayo Clinic from 2003 to 2011, comprehensively characterized and with prospectively measured left atrial volume index and tissue Doppler imaging a' in routine practice, were enrolled, and their long-term survival analyzed. Read More

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Effects of Metoprolol on Exercise Hemodynamics in Patients With Obstructive Hypertrophic Cardiomyopathy.

J Am Coll Cardiol 2022 04;79(16):1565-1575

Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.

Background: The relationship between exercise hemodynamics, loading conditions, and medical treatment in patients with obstructive hypertrophic cardiomyopathy (HCM) is incompletely understood.

Objectives: This study aimed to investigate the effect of metoprolol on invasive hemodynamic parameters at rest and during exercise in patients with obstructive HCM.

Methods: This randomized, double-blind, placebo-controlled crossover trial enrolled 28 patients with obstructive HCM and New York Heart Association functional class ≥II. Read More

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Early Outcomes of Patients Undergoing Neoaortic Valve Repair Incorporating Geometric Ring Annuloplasty.

World J Pediatr Congenit Heart Surg 2022 05;13(3):304-309

University of Michigan, Ann Arbor, MI, USA.

Objectives: During congenital heart surgery, the pulmonary valve and root may be placed into the systemic position, yielding a "neoaortic" valve. With the stress of systemic pressure, the pulmonary roots can dilate, creating aneurysms and/or neoaortic insufficiency (neoAI). This report analyzes the early outcomes of patients undergoing neoaortic valve repair incorporating geometric ring annuloplasty. Read More

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Surgery for Functional Tricuspid Regurgitation in Adult Atrial Septal Defect - An Increasing Subject in a Decreasing Matter.

Braz J Cardiovasc Surg 2022 May 23;37(3):306-314. Epub 2022 May 23.

Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.

Introduction: Functional tricuspid regurgitation (TR) is known to complicate adult atrial septal defect (ASD), but its management is still under debate. We reviewed our experience in ASD surgery, focusing on associated functional TR and its treatment.

Methods: This retrospective study (2005-2019) included 206 consecutive adult ASD surgical cases without associated valve pathology, except functional TR. Read More

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Paravalvular Leak.

Methodist Debakey Cardiovasc J 2022 1;18(1):7-9. Epub 2022 Apr 1.

Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, US.

Despite improvements and advancements in surgical technique, paravalvular leaks (PVL) continue to present a challenge when caring for patients with prosthetic valve disease. Paravalvular leaks result from dehiscence of the surgical ring from the mitral annulus. Some theories suggest that uneven distribution of collagen fibers in the mitral annulus leaves the posterior mitral annulus without a well-formed fibrous structure, which may predispose it to recurrent mechanical injury that leads to PVL. Read More

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Ventricular Arrhythmias and Sudden Death Following Percutaneous Pulmonary Valve Implantation in Pediatric Patients.

Pediatr Cardiol 2022 Apr 8. Epub 2022 Apr 8.

Division of Cardiology, Department of Pediatrics, CHU Mère-Enfants Sainte-Justine, Université de Montréal, Montreal, QC, Canada.

Reports have suggested a transient increase in ventricular ectopy early after percutaneous pulmonary valve implantation (PPVI). Little is known about the potential for more serious ventricular arrhythmias (VA) in children who undergo PPVI. We sought to evaluate the incidence of severe VA following PPVI in a pediatric population and to explore potential predictive factors. Read More

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Unexpected isolated native pulmonary valve endocarditis; really benign as thought?

J Card Surg 2022 Jul 5;37(7):2120-2123. Epub 2022 Apr 5.

Department of Pediatric Cardiovascular Surgery, Koşuyolu High Speciality Educational and Research Hospital, University of Health Sciences Turkey, İstanbul, Turkey.

Background: Isolated pulmonary valve endocarditis is extremely rare, accounting for <2% of cases. Major predisposing factors are intravenous drug use, implanted cardiac devices, congenital heart diseases, and central venous catheters. Most patients respond well to appropriate antibiotherapy. Read More

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Pulmonary valve reconstruction using autologous pericardium. A promising technique to consider.

Ann Thorac Surg 2022 Apr 1. Epub 2022 Apr 1.

Cardiovascular Surgery Department, National Cardiovascular Institute, EsSalud, Lima, Peru.

Pulmonary valve (PV) surgery is uncommon in adults; however, when indicated, replacement with a prosthesis is suggested. Nevertheless, mechanical prostheses have an inherent risk of complications derived from anticoagulation and thrombosis, and biological prostheses do not have adequate long-term durability. In this context, PV reconstruction surgery emerges as alternative avoiding anticoagulation and promising good durability. Read More

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The impact of a bicuspid pulmonary valve in the aortic position after arterial switch for transposition of the great arteries on neoaortic root dimension and function: a propensity score matched analysis.

Interact Cardiovasc Thorac Surg 2022 06;34(6):1106-1112

Division of Pediatric Cardiac Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objectives: This study investigated the effect of a bicuspid pulmonary valve on neoaortic root morphology, function, and the clinical outcomes of early survivors after the arterial switch operation using propensity score matching.

Methods: From 1997 to 2018, a total of 442 patients underwent the arterial switch operation for transposition of the great arteries. After exclusion of patients who underwent a staged repair, were repaired beyond 1 year of age, died before discharge and who lacked echocardiographic data at discharge, propensity score matching was used for analysis. Read More

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The role of the extracellular matrix in the development of heart valve disease: Underestimation or undercomprehension?

Francesco Nappi

J Card Surg 2022 Jun 30;37(6):1623-1626. Epub 2022 Mar 30.

Department of Cardiac Surgery, Centre Cardiologique du Nord, Saint-Denis, France.

The function of metalloproteinases of the extracellular matrix and their inhibitors has emerged with a crucial role in valve diseases. Both the expression of matrix metalloproteinases and their inhibitors are susceptible to modification in patients with severe mitral insufficiency. This process is due to substantial changes in the collagen structure during mechanical stress on the mitral valve leaflets. Read More

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Acute haemodynamic impact of transcatheter aortic valve implantation in patients with severe aortic stenosis.

ESC Heart Fail 2022 06 29;9(3):1721-1730. Epub 2022 Mar 29.

Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Aims: There are limited data about the intraprocedural haemodynamic study performed immediately before and after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS). We aimed to evaluate the acute haemodynamic impact of TAVI in patients with severe AS and to investigate invasive and non-invasive parameters predicting all-cause mortality.

Methods And Results: A total of 245 consecutive AS patients (43% male, mean age 80. Read More

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Long-term Outcomes of the Ross Procedure for Young Patients with Aortic Valve Disease.

Semin Thorac Cardiovasc Surg 2022 Mar 25. Epub 2022 Mar 25.

Division of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.

To define current role of the Ross operation in young patients, the outcome in those followed longer than 20 years were assessed. Between 1994 and 2020, 81 consecutive patients, 70 of 11 male and/or female, mean age 27 years underwent Ross procedure, accruing 20 years of follow-up or longer. Sixty-four had bicuspid valve (79%) and 54 (67%) aortic insufficiency, while 15 (19%) had undergone prior operations. Read More

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