1,440 results match your criteria Pulmonary Sequestration Imaging


Pulmonary sequestration with Aspergillus infection presenting as massive hemoptysis and hemothorax with highly elevated carcinoembryonic antigen in pleural effusion that mimics advanced lung malignancy.

Eur J Med Res 2021 May 25;26(1):48. Epub 2021 May 25.

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, 610046, Sichuan, China.

Background: Pulmonary sequestration (PS) associated with massive hemoptysis, hemothorax, and elevated tumor markers or even lung malignancy has been reported in several studies. These clinical features combined with lung lesions on chest imaging are sometimes hard to differentiate from lung malignancies and often complicate the diagnostic procedure.

Case Presentation: A 45-year-old man with PS presented with massive hemoptysis, hemothorax, and extremely elevated carcinoembryonic antigen (CEA) in pleural effusion was initially misdiagnosed with advanced lung carcinoma, but was ultimately diagnosed with PS with Aspergillus infection. Read More

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Characterization of the Hyperintense Bronchus Sign as a Fetal MRI Marker of Airway Obstruction.

Radiology 2021 May 25:204565. Epub 2021 May 25.

From the Department of Biomedical Imaging and Image-guided Therapy (F.P., A.H., M.W., H.P., D.P., G.K.), Center for Anatomy and Cell Biology (P.C.B.), Department of Pathology (A.S.), Division of Paediatric Surgery, Department of Surgery (M.M.), and Department of Obstetrics and Gynaecology (J.B.), Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; E. B. Singleton Department of Radiology, Texas Children's Hospital, Houston, Tex (A.R.M.R., C.C.C.); and Division of Anatomy and Developmental Biology, Karl Landsteiner University of Health Sciences, Krems, Austria (G.M.G.).

Background Fetal MRI-based differential diagnosis of congenital lung malformations is difficult because of the paucity of well-described imaging markers. Purpose To characterize the hyperintense bronchus sign (HBS) in in vivo fetal MRI of congenital lung malformation cases. Materials and Methods In this retrospective two-center study, fetal MRI scans obtained in fetuses with congenital lung malformations at US (January 2002 to September 2018) were reviewed for the HBS, a tubular or branching hyperintense structure within a lung lesion on T2-weighted images. Read More

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A rare case report of simultaneous occurrence of a pediatric pleuropulmonary blastoma and an intralobar pulmonary sequestration.

Radiol Case Rep 2021 Jul 30;16(7):1727-1731. Epub 2021 Apr 30.

Morphology Department, Faculty of Medicine, University of Medicine, Tirane, Albania.

We are presenting a rare case with the simultaneous occurrence of pleuropulmonary blastoma and an intra lobar pulmonary sequestration. Although there have been cases reported previously with pleuropulmonary blastoma associated with congenital pulmonary malformations, the association with an intra lobar pulmonary sequestration is very rare. The patient, a female, 6-month-old child arrived at our pediatric service with the clinic of cough, respiratory distress, and fever after being treated for 2 weeks for left lung bronchopneumonia according clinical signs and radiographic description but without clinical improvements. Read More

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Radiologically Undetectable Latent Pulmonary Lymphocyte Infiltration Suggesting the Need for Early Glucocorticoid Therapy: An Autopsy Case of Rapidly Progressive COVID-19 Pneumonia with Lymphopenia.

Intern Med 2021 May 14. Epub 2021 May 14.

Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Japan.

We herein report a fatal case of COVID-19 pneumonia with rapid progression of respiratory failure and lymphopenia. Excessive recruitment and sequestration of lymphocytes in the lung were suggested as the pathophysiology underlying COVID-19-associated lymphopenia. Interestingly, the autopsy in this case revealed lymphocytic infiltration in the lungs even at sites that appeared normal on autopsy imaging. Read More

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An Adult Case of Multiple Extralobar Pulmonary Sequestrations in the Thoracic and Abdominal Cavities.

Ann Thorac Surg 2021 Apr 8. Epub 2021 Apr 8.

Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.

Extralobar pulmonary sequestration is generally located in the left thoracic cavity and is often identified prenatally or in infants. We experienced a rare case of multiple extralobar pulmonary sequestrations in the thoracic and abdominal cavities, incidentally detected in a 60-year-old woman by cancer screening. The patient underwent surgery by thoracoscopic and laparoscopic approaches simultaneously, and extralobar sequestration was histologically confirmed in each lesion. Read More

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Multidisciplinary management of a rare case of mixed total anomalous pulmonary venous connection.

J Card Surg 2021 Jul 29;36(7):2562-2564. Epub 2021 Mar 29.

Division of Pediatric Surgery, Department of Emergencies and Organ Transplantation, University of Bari, Bari, Italy.

Introduction: Mixed total anomalous pulmonary venous connection (TAPVC) is a extremely rare congenital heart disease.

Methods: We report the initial management of a case of Mixed total anomalous pulmonary venous connection associated to right extralobar bronchopulmonary sequestration (BPS).

Results: Mixed TAPVC associated to right extra-lobar BPS was diagnosed at birth in a full-term newborn. Read More

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Combined surgical therapy for pulmonary sequestration and aberrant artery from the abdominal aorta.

Gen Thorac Cardiovasc Surg 2021 Jun 20;69(6):1031-1034. Epub 2021 Mar 20.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Pulmonary sequestration with feeding vessels from the abdominal aorta is relatively rare. A 56-year-old woman with chronic left thoracic pain was referred to our hospital. Computed tomography showed multiple pulmonary cysts in the left lung and an aberrant artery from the abdominal aorta. Read More

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Prenatal Imaging Diagnosis of Suprarenal Lesions.

Fetal Diagn Ther 2021 17;48(3):235-242. Epub 2021 Mar 17.

Department of Surgery, Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, USA,

Introduction: Prenatal suprarenal lesions represent diverse pathologies. This study investigated prenatal imaging features and regression patterns associated with specific lesion diagnoses.

Methods: This is a multicenter retrospective review of fetuses with prenatally diagnosed suprarenal lesions between 2001 and 2019. Read More

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Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action.

ACS Nano 2021 05 16;15(5):8095-8109. Epub 2021 Mar 16.

Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

RNA therapeutics are poised to revolutionize medicine. To unlock the full potential of RNA drugs, safe and efficient (nano)formulations to deliver them inside target cells are required. Endosomal sequestration of nanocarriers represents a major bottleneck in nucleic acid delivery. Read More

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Circular RNA TRAPPC6B inhibits intracellular growth while inducing autophagy in macrophages by targeting microRNA-874-3p.

Clin Transl Immunology 2021 18;10(2):e1254. Epub 2021 Feb 18.

Department of Clinical Immunology Institute of Laboratory Medicine Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Guangdong Medical University Dongguan China.

Objectives: Genetic and epigenetic mechanisms regulate antimicrobial immunity against (Mtb) infection.

Methods: The present study assessed circular RNA TRAPPC6B (circTRAPPC6B) for antimicrobial immune functions and defined mechanisms wherein circTRAPPC6B regulates Mtb growth, autophagy and microRNA in macrophages.

Results: The Mtb infection of monocytes/macrophages resulted in a significantly decreased level of circTRAPPC6B that inhibited intracellular Mtb growth in macrophages. Read More

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February 2021

Revising the classification of lung sequestrations.

Clin Imaging 2021 Feb 23;77:92-97. Epub 2021 Feb 23.

Unit of Pediatric Radiology, Department of Radiology, University Hospital of Lausanne (CHUV) and University of Lausanne (UNIL), Rue du Bugnon 46, 1011 Lausanne, Switzerland. Electronic address:

Purposes: The classification of lung sequestrations distinguishes between extralobar and intralobar types, according to their venous drainage - systemic vs pulmonary - and the presence or absence of independent pleura. However, imaging, surgical and/or pathological findings often differ from this description. The objectives of this article are to quantify the percentage of lung sequestrations that do not fit the classic description of extra- and intralobar types and to evaluate the accuracy of the currently used classification. Read More

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February 2021

Rare cause of haemoptysis: bronchopulmonary sequestration.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Respiratory Medicine, Basildon and Thurrock University Hospitals, Mid and South Essex NHS Foundation Trust, Basildon, UK

Bronchopulmonary sequestration is a rare congenital pulmonary abnormality of the lower airways, which includes an abnormal and non-functioning lung tissue not communicating with the tracheobronchial tree and having aberrant blood supply from systemic circulation with variable venous drainage. The incidence of sequestration is around 0.15%-6. Read More

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Reference range of fetal thorax using two-dimensional and three-dimensional ultrasound VOCAL technique and application in fetal thoracic malformations.

BMC Med Imaging 2021 Feb 22;21(1):34. Epub 2021 Feb 22.

Department of Ultrasound Medicine, Second Affiliated Hospital of Fujian Medical University, No. 2 Ji'an Road, Fengze District, Quanzhou, China.

Background: To establish the normal reference range of fetal thorax by two-dimensional (2D) and three-dimensional (3D) ultrasound VOCAL technique and evaluate the application in diagnosing fetal thoracic malformations.

Methods: A prospective cross-sectional study was undertaken involving 1077 women who have a normal singleton pregnancy at 13-40 weeks gestational age (GA). 2D ultrasound and 3D ultrasound VOCAL technique were utilized to assess fetal thoracic transverse diameter, thoracic anteroposterior diameter, thoracic circumference, thoracic area, lung volume, thoracic volume and lung-to-thoracic volume ratio. Read More

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February 2021

Usefulness of prenatal magnetic resonance imaging in differential diagnosis of fetal congenital cystic adenomatoid malformation and bronchopulmonary sequestration.

World J Clin Cases 2021 Feb;9(4):822-829

Department of Ultrasound, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, China.

Background: Congenital cystic adenomatoid malformation (CCAM) and bronchopulmonary sequestration (BPS) are the most common lung diseases in fetuses. There are differences in the prognosis and treatment of CCAM and BPS, and the clinical diagnosis and treatment plan is usually prepared prior to birth. Therefore, it is quite necessary to make a clear diagnosis before delivery. Read More

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February 2021

Thoracoscopic treatment of a rare bilateral extralobar lung sequestration in a 3-years old girl.

Pediatr Med Chir 2021 Feb 8;42(2). Epub 2021 Feb 8.

Department of Pediatric Surgery and Pediatric Minimally Invasive Surgery and New Technologies, San Bortolo Hospital, Vicenza.

Majority of sequestrations fall into two categories: Intra-Lobar (ILS) and Extra-Lobar (ELS). Rarely the abnormal lung could be attached to the gastrointestinal tract, Bronchopulmonary Foregut Malformation (BPFM). We described a case of a girl of 3-years-old with antenatal diagnosis of left intrathoracic mass of the inferior lobe. Read More

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February 2021

Pulmonary sequestration: What the radiologist should know.

Clin Imaging 2021 May 3;73:61-72. Epub 2020 Dec 3.

Diagnostic and Interventional Radiology, Department of Translational Research, University of Pisa, Via Roma, 67, 56126 Pisa, Italy.

Pulmonary sequestration consists of a nonfunctioning mass of lung tissue, either sharing the pleural envelope of the normal lung (intralobar) or with its own pleura (extralobar), lacking normal communication with the tracheobronchial tree and receiving its arterial supply by one or more systemic vessels. It is the second most common congenital lung anomaly according to pediatric case series, but its real prevalence is likely to be underestimated, and imaging plays a key role in the diagnosis and treatment management of the condition and its potential complications. We will give a brief overview of the pathophysiology, clinical presentation and imaging findings of intra- and extralobar pulmonary sequestration, with particular reference to multidetector computed tomography as part of a powerful and streamlined diagnostic approach. Read More

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Imaging of solid congenital abdominal masses: a review of the literature and practical approach to image interpretation.

Pediatr Radiol 2020 12 30;50(13):1907-1920. Epub 2020 Nov 30.

Department of Radiology, Pediatric Section, Baylor Scott and White Health-Temple, McLane Children's Medical Center, Texas A&M Health Science Center, 2401 S. 31st St., MS-01-W256, Temple, TX, 76508, USA.

Fetal abdominal tumors are rare, usually benign, and cause a great deal of anxiety for expectant parents and the physicians counseling them. In this paper the author reviews the most common fetal abdominal tumors in the liver (hemangioma, mesenchymal hamartoma, hepatoblastoma, metastases) and the kidney (congenital mesoblastic nephroma, Wilms tumor, malignant rhabdoid tumor, and clear cell sarcoma), and suprarenal mass lesions (adrenal neuroblastoma, adrenal hemorrhage, and subdiaphragmatic extralobar pulmonary sequestration). The author describes the imaging approach, imaging appearance and differentiating features of tumors, and differences between fetal and childhood appearances of tumors. Read More

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December 2020

Fetal ultrasound and magnetic resonance imaging: a primer on how to interpret prenatal lung lesions.

Pediatr Radiol 2020 12 30;50(13):1839-1854. Epub 2020 Nov 30.

Department of Radiology, National Maternity Hospital, Dublin, Ireland.

Fetal lung lesions include common lesions such as congenital pulmonary airway malformation (CPAM), bronchopulmonary sequestration (BPS) and combined CPAM-BPS hybrid lesions, as well as less common entities including congenital lobar emphysema/obstruction, bronchial atresia, bronchogenic cysts and rare malignant pulmonary lesions such as pleuropulmonary blastoma. Fetal lung lesions occur in approximately 1 in 15,000 live births and are thought to arise from a spectrum of abnormalities related to airway obstruction and malformation, with the lesion type depending on the timing of insult, level of bronchial tree involvement, and severity of obstruction. Lesions vary from small and asymptomatic to large and symptomatic with significant mass effect on surrounding structures. Read More

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December 2020

A Modified VATS Procedure for Treating Adult Intralobar Pulmonary Sequestration.

Thorac Cardiovasc Surg 2021 03 17;69(2):194-196. Epub 2020 Nov 17.

Department of Thoracic Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China.

Video-assisted thoracoscopic surgery (VATS) makes it possible to treat intralobar sequestration (ILS) more minimally invasive compared with conventional open surgery. However, this procedure is challenging to expose and isolate the aberrant arteries of ILS and the risk of bleeding is high. Herein, we developed a modified VATS procedure in which the aberrant vessels are treated in the last step of lobectomy, rather than at the beginning. Read More

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[UNILATERAL MULTI-CYSTIC LUNG DISEASE IN A PRETERM INFANT].

Harefuah 2020 Oct;159(10):735-738

Department of Neonatal Intensive Care, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Introduction: Cystic diseases of the lung are a rare spectrum of anomalies, commonly diagnosed prenatally. We present a case of a newborn twin, born at 29 weeks gestational. The infant was diagnosed with respiratory distress syndrome shortly after birth, treated with surfactant by the INSURE method (intubation, surfactant administration, extubation) and required only short-term non-invasive ventilation. Read More

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October 2020

Three-dimensional computed tomography and indocyanine green-guided technique for pulmonary sequestration surgery.

Gen Thorac Cardiovasc Surg 2021 Mar 19;69(3):621-624. Epub 2020 Oct 19.

Division of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Nagano, 390-8621, Japan.

Patients with pulmonary sequestration are at risk of life-threatening bleeding during lung resection. To perform safe and adequate lung resection in patients with pulmonary sequestration, we utilized the following combination of techniques: (1) three-dimensional computed tomographic (3D-CT) imaging for preoperative planning and intraoperative identification of blood vessels, including aberrant arteries, and (2) intraoperative intravenous administration of indocyanine green (ICG). We describe our surgical technique through three cases who underwent lung resection for pulmonary sequestration using 3D-CT and fluorescence navigation with ICG. Read More

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A Scimitar Syndrome Variant Associated with Critical Aortic Coarctation in a Newborn.

Am J Case Rep 2020 Oct 8;21:e923162. Epub 2020 Oct 8.

Mother and Child Health Institute of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.

BACKGROUND Scimitar syndrome (SCS) is a rare congenital cardiopulmonary malformation, characterized by anomalous pulmonary venous drainage from the right lung associated with aortopulmonary collateral arteries and pulmonary hypoplasia. The variant described in the case presented here, with total anomalous right pulmonary venous drainage into the superior and inferior vena cava, can be expected in 2% of patients with scimitar syndrome. To the best of our knowledge, the association between the variant of SCS and coarctation of aorta described in our patient has never been reported before in the literature. Read More

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October 2020

Extralobar pulmonary sequestration with elevated serum neuron-specific enolase: A case report and review of the literature.

Medicine (Baltimore) 2020 Oct;99(40):e22574

Department of Surgery, Xuzhou Central Hospital, Xuzhou, China.

Rationale: Pulmonary sequestration (PS) presenting with elevated serum tumor markers is rare, and it might be misdiagnosed as malignancy.

Patient Concerns: A 26-year-old asymptomatic male patient was admitted because the x-ray showed an intrathoracic lesion. Meanwhile, the serum neuron-specific enolase (NSE) was elevated. Read More

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October 2020

Combined endovascular and surgical approaches to treat intralobar pulmonary sequestration: a case report.

Ann R Coll Surg Engl 2021 Jan 24;103(1):e35-e37. Epub 2020 Sep 24.

Newcastle upon Tyne Hospitals, Newcastle upon Tyne, UK.

Pulmonary sequestration is a congenital abnormality of a non-functional pulmonary mass with anomalous systemic arterial supply. Surgical resection is the gold standard treatment, but it carries a risk of life-threatening haemorrhage from accidental injury of the anomalous artery. Endovascular embolisation has been introduced as a safe alternative, but does not eliminate the possibility of symptom recurrence. Read More

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January 2021

Combined Pre- and Postnatal Minimally Invasive Approach to Complicated Pulmonary Sequestrations.

European J Pediatr Surg Rep 2020 Jan 18;8(1):e62-e67. Epub 2020 Sep 18.

Department of Pediatric Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Lombardia, Italy.

Pulmonary sequestration (PS) is mostly asymptomatic but there is a proportion of fetuses that develop hydrops, leading to fetal or neonatal death. Fetal treatments are available, but postnatal management of the residual lesions is not uniformly defined. We present two cases of combined pre- and postnatal minimally invasive approach to complicated extra-lobar PS. Read More

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January 2020

Ganglioneurofibroma arising within the extralobar pulmonary sequestration.

J Cardiothorac Surg 2020 Sep 11;15(1):252. Epub 2020 Sep 11.

Department of Thoracic Surgery, Xuzhou Central Hospital, 199 Jiefang South Road, Xuzhou, 221009, China.

Background: Neurogenic tumor arising within the pulmonary sequestration (PS) is rare.

Case Presentation: A 42-year-old asymptomatic female was referred to our hospital for work-up of extralobar PS. The independent feeding artery from the thoracic aorta was confirmed by three-dimensional computed tomography angiography (3D-CTA). Read More

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September 2020

Congenital intrathoracic accessory spleen is a very rare trick of nature: a case report.

J Cardiothorac Surg 2020 Aug 31;15(1):232. Epub 2020 Aug 31.

Department of Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Dr., Iowa City, Iowa, 52242, USA.

Background: Congenital intrathoracic accessory spleen (CIAS) refers to a developmental anomaly resulting in the presence of splenic tissue within the chest. The differential diagnoses for the resulting mass are pulmonary malformations, or lesions with malignant potential. To our knowledge, only four cases of presumed CIAS have been described in literature to date, and no cases were reported in the United States. Read More

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Intralobar Sequestration Associated With the Coronary-Pulmonary Artery Fistula From the System of the Circumflex Artery.

Circ Cardiovasc Imaging 2020 09;13(9):e010234

Department of Atherosclerosis and Coronary Artery Disease (O.Y.V., A.A.B.), Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences. Russian Federation.

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September 2020

Congenital lung abnormality quantification by computed tomography: The CLAQ method.

Pediatr Pulmonol 2020 11 26;55(11):3152-3161. Epub 2020 Aug 26.

Department of Paediatric Pulmonology, Erasmus University Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands.

Introduction: To date, no consensus has been reached on the optimal management of congenital lung abnormalities, and factors predicting postnatal outcome have not been identified. We developed an objective quantitative computed tomography (CT) scoring method, and assessed its value for clinical decision-making.

Methods: Volumetric CT-scans of all patients born with a congenital lung abnormality between January 1999 and 2018 were assessed. Read More

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November 2020

Treatment of an Aberrant Arterial Aneurysm with Intralobar Pulmonary Sequestration: A Case Report.

Ann Vasc Surg 2020 Nov 5;69:453.e11-453.e14. Epub 2020 Aug 5.

Department of Surgery, Ibaraki Prefectural Central Hospital & Cancer Center, Kasama, Ibaraki, Japan.

An aberrant arterial aneurysm with pulmonary sequestration is rare. Here, we report about a 35-year-old man who had no symptoms related to pulmonary sequestration. Computed tomography revealed an aberrant arterial aneurysm with an 18 mm in diameter with intralobar pulmonary sequestration, which gradually increased in size to 27 mm over 5 years. Read More

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November 2020