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Matrix Biol 2022 May 23. Epub 2022 May 23.

Divisions of Cell Matrix Biology & Regenerative Medicine and Cardiovascular Sciences, School of Biological Science, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Electronic address:

Extracellular matrix (ECM) in the intervertebral disc (IVD), lung and artery are thought to undergo the age-dependant accumulation of damage by chronic exposure to mechanisms such as reactive oxygen species, proteases and glycation. It is unknown whether this damage accumulation is species-dependant (via differing lifespans and hence cumulative exposures) or whether it can influence the progression of age-related diseases such as atherosclerosis. Peptide location fingerprinting (PLF) is a new proteomic analysis method, capable of the non-targeted identification of structure-associated changes within proteins. Read More

PLoS One 2022 26;17(5):e0268589. Epub 2022 May 26.

Department of Chest diseases, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Objectives: We aimed to compare the effects of different aerobic exercise training (ET) programs on respiratory performance, exercise capacity, and quality of life in fibrosing interstitial lung diseases (f-ILD).

Methods: A case-control study where 31 patients with f-ILD diagnosis based on chest high-resolution computed tomography were recruited from Main Alexandria University hospital-Egypt. Ten patients were randomly assigned for only lower limbs (LL) endurance training program, and 10 patients for upper limbs, lower limbs, and breathing exercises (ULB) program for consecutive 18 sessions (3 sessions/week for 6 consecutive weeks). Read More

Chron Respir Dis 2022 Jan-Dec;19:14799731221104102

International Physiotherapy Research Network (PhysioEvidence), Barcelona, Spain.

Introduction: The Coronavirus disease (COVID-19) pandemic has significantly altered the provision of rehabilitation services, especially pulmonary rehabilitation (PR). Our objective was to assess the provision of PR services in Latin America 18 months after the COVID-19 pandemic was declared.

Methods: A cross-sectional study that included professionals dedicated to PR in centres in Latin America was applied. Read More

ERJ Open Res 2022 Apr 23;8(2). Epub 2022 May 23.

COPD Center, Dept of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden.

It is a challenge to keep abreast of all the clinical and scientific advances in the field of respiratory medicine. This article contains an overview of laboratory-based science, randomised controlled trials and qualitative research that were presented during the 2021 European Respiratory Society International Congress within the sessions from the five groups of the Assembly 1 - Respiratory clinical care and physiology. Selected presentations are summarised from a wide range of topics: clinical problems, rehabilitation and chronic care, general practice and primary care, electronic/mobile health (e-health/m-health), clinical respiratory physiology, exercise and functional imaging. Read More

ERJ Open Res 2022 Apr 23;8(2). Epub 2022 May 23.

Center for Innovative Care and Health Technology (ciTechCare), School of Health Sciences (ESSLei), Polytechnic of Leiria, Leiria, Portugal.

This paper provides an overview of some of the most memorable sessions that were (co)organised by the Allied Respiratory Professionals Assembly during the 2021 European Respiratory Society International Congress, which was held online for the second consecutive year due to the COVID-19 pandemic. Early Career Members from Assembly 9 summarised the content of the sessions (three oral communication sessions, two symposia and one Expert View) with the support of the chairs from the four Assembly groups: Respiratory Function Technologists and Scientists (Group 9.01); Physiotherapists (Group 9. Read More

Front Med (Lausanne) 2022 9;9:889218. Epub 2022 May 9.

Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy.

Mechanical ventilation (MV) is currently considered a life-saving intervention. However, growing evidence highlighted that prolonged MV significantly affects functional outcomes and length of stay. In this scenario, controversies are still open about the optimal rehabilitation strategies for improving MV duration in ICU patients. Read More

Neuroimmunomodulation 2022 May 25:1-8. Epub 2022 May 25.

Department of Rehabilitation, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.

Background: This study aimed to observe the changes of resting energy metabolism in patients with severe neurological diseases, and to explore the effects of tracheostomy status, stroke severity, and complications on resting energy expenditure (REE) and respiratory quotient (RQ).

Methods: A retrospective study was conducted in 105 patients with neurological rehabilitation who were hospitalized in the Rehabilitation Department of the Affiliated Jiangning Hospital of Nanjing Medical University from August 2018 to October 2021. REE was measured by Italian Cosmed k4b2 indirectly, and white blood cell count and C-reactive protein (CRP) were collected. Read More

Med Sci Sports Exerc 2022 May 25. Epub 2022 May 25.

Department of Neuroscience, Biomedicine, and Movement, University of Verona, ITALY.

Purpose: This study evaluated whether central motor drive during fatiguing exercise plays a role in determining performance and the development of neuromuscular fatigue during a subsequent endurance task.

Methods: On separate days, 10 males completed 3 constant-load (80% peak-power output), single-leg knee-extension trials to task failure in a randomized fashion. One trial was performed without pre-existing quadriceps fatigue (CON), and 2 trials were performed with pre-existing, quadriceps fatigue induced either by voluntary (VOL; involving central motor drive) or electrically-evoked (EVO; without central motor drive) quadriceps contractions (~20% maximal voluntary contraction (MVC)). Read More

Stud Health Technol Inform 2022 May;294:730-734

eHealth Department, Roessingh Research and Development, The Netherlands.

Exercise games (exergames) can help COPD patients stay active and prevent exacerbation. When evaluating such exergames, patient values are an important variable to take into account. In this study, seven COPD patients used an exergame technology at the physiotherapist for six months. Read More

Mol Cells 2022 May 23. Epub 2022 May 23.

Department of Respiratory, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China.

Extracellular vesicles (EVs) play an essential role in the communication between cells and the tumor micro-environment. However, the effect of tumor-derived EVs on the growth and metastasis of lung adenocarcinoma (LUAD) remains to be explored. This study aimed to elucidate the role of miR-153-3p-EVs in the invasion and migration capabilities of LUAD cells and explore its mechanism through and experiments. Read More

Crit Care 2022 May 24;26(1):152. Epub 2022 May 24.

Intensive Care Unit, Glasgow Royal Infirmary, Glasgow, UK.

Background: Caregivers and family members of Intensive Care Unit (ICU) survivors can face emotional problems following patient discharge from hospital. We aimed to evaluate the impact of a multi-centre integrated health and social care intervention, on caregiver and family member outcomes.

Methods: This study evaluated the impact of the Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE) programme across 9 sites in Scotland. Read More

Spinal Cord 2022 May 24. Epub 2022 May 24.

Rehabilitation Department, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province, 230031, PR China.

Study Design: Cross-sectional study.

Objective: To elucidate the association between age and incidence of deep vein thrombosis (DVT) in patients with spinal cord injury (SCI).

Setting: Rehabilitation Medicine Department of the First Affiliated Hospital of China University of Science and Technology. Read More

J Prosthet Dent 2022 May 21. Epub 2022 May 21.

Private practice, Portland, Ore; Adjunct Professor, Department of Oral and Maxillofacial Surgery, OHSU, Portland, Ore.

This clinical report describes the design and fabrication of an implant-retained and soft-tissue-supported obturator prosthesis and a magnetic retained midfacial prosthesis for a patient with a midfacial defect following bilateral total maxillectomy, removal of the left zygoma, and excision of the entire upper lip. The patient underwent multiple head and neck surgeries for 4 separate primary oral cancers, 1 recurrence, and 1 pulmonary metastasis. The definitive obturator prosthesis was retained by 1 zygomatic implant with soft-tissue support and retention. Read More

BMJ Open Respir Res 2022 May;9(1)

LHL Hospital Gardermoen, Jessheim, Norway.

Background: The Dyspnoea-12 (D-12) questionnaire is widely used and tested in patients with breathing difficulties. The objective of this study was to translate and undertake the first evaluation of the measurement properties of the Norwegian version of the D-12 in patients with chronic obstructive pulmonary disease (COPD) attending a 4-week inpatient pulmonary rehabilitation programme.

Methods: Confirmatory factor analysis was used to assess structural validity. Read More

JMIR Rehabil Assist Technol 2022 May 17. Epub 2022 May 17.

Graduate School and Research, Arcada University of Applied Sciences, Helsinki, FI.

Background: The ongoing COVID-19 pandemic has required social, health, and rehabilitation organizations to implement remote physiotherapy (RP) as a part of physiotherapists' daily practice. RP may improve access to physiotherapy as it delivers physiotherapy services to rehabilitees through information and communication technology (ICT). Even if RP has already been introduced in this century, physiotherapist opinion, amount of use, and form in daily practice has not been studied extensively. Read More

Eur Heart J 2022 May 24. Epub 2022 May 24.

Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield National Health Service Foundation Trust, Imperial College London, SW3 6NP London, UK.

Congenital heart disease (CHD) is often comprised of complex three-dimensional (3D) anatomy that must be well understood to assess the pathophysiological consequences and guide therapy. Thus, detailed cardiac imaging for early detection and planning of interventional and/or surgical treatment is paramount. Advanced technologies have revolutionized diagnostic and therapeutic practice in CHD, thus playing an increasing role in its management. Read More

J Appl Physiol (1985) 2022 May 19. Epub 2022 May 19.

Academic Department of Military Medicine, Birmingham, United Kingdom.

Background: A failure to fully recover following coronavirus disease 2019 (COVID-19) may have a profound impact on high functioning populations ranging from front-line emergency services to professional or amateur/recreational athletes.

Aim: To describe the medium-term cardiopulmonary exercise profiles of individuals with 'persistent symptoms' and individuals who feel 'recovered' after hospitalization or mild-moderate community infection following COVID-19 to an age, sex and job-role matched control group.

Methods: 113 participants underwent cardiopulmonary functional tests at a mean 159±7 days (~5 months) following acute illness; 27 hospitalized with persistent symptoms (hospitalized-symptomatic), 8 hospitalized and now recovered (hospitalized-recovered); 34 community managed with persistent symptoms (community-symptomatic); 18 community managed and now recovered (community-recovered), and 26 controls. Read More

BJS Open 2022 May;6(3)

Department of Anaesthesiology and Intensive Care Medicine, Hôpital Nord, Hôpitaux Universitaires de Marseille, Aix Marseille University, Marseille, France.

Background: Physiotherapy is a major cornerstone of enhanced rehabilitation after surgery (ERAS) and reduces the development of atelectasis after thoracic surgery. By initiating physiotherapy in the post-anaesthesia care unit (PACU), the aim was to evaluate whether the ultra-early initiation of rehabilitation (in the first hour following tracheal extubation) would improve the outcomes of patients undergoing elective thoracic surgery.

Methods: A case-control study with a before-and-after design was conducted. Read More

Comput Math Methods Med 2022 14;2022:3049619. Epub 2022 May 14.

Department of Internal Medicine, College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, China.

Objective: Bioinformatics methods were used to analyze non-small-cell lung cancer gene chip data, screen differentially expressed genes (DEGs), explore biomarkers related to NSCLC prognosis, provide new targets for the treatment of NSCLC, and build immunotyping and line-map model.

Methods: NSCLC-related gene chip data were downloaded from the GEO database, and the common DEGs of the two datasets were screened by using the GEO2R tool and FunRich 3.1. Read More

Respir Med 2022 May 16:106881. Epub 2022 May 16.

School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada; Respiratory Medicine, West Park Healthcare Centre, Toronto, Ontario, Canada; Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health Sciences, University of Aveiro (ESSUA), Aveiro, Portugal; Institute for Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal. Electronic address:

Pulmonary rehabilitation (PR) is a multidisciplinary intervention forming the cornerstone of chronic respiratory disease management, improving individuals' exercise capacities and abilities to complete activities of daily living (ADLs). Although the occupational therapy (OT) scope of practice focuses on similar outcomes as PR, the tasks/roles and benefit of including OT in PR has not been reviewed. This scoping review synthesized the i) tasks/roles, ii) recommendations of guidelines, iii) prevalence and iv) effects of OT as part of PR programs. Read More

Health Psychol 2022 Jun;41(6):379-388

Department of Psychology, The Ohio State University.

Objective: Of all cancers, advanced nonsmall cell lung cancer (NSCLC) is associated with the highest burden on mental and physical health-related quality of life (HRQoL). Patients' subjective beliefs about their cancer (i.e. Read More

Ir Med J 2020 Jul 30;113(7):141. Epub 2020 Jul 30.

Our Lady of Lourdes Hospital, Drogheda, RCSI Hospital Group.

Front Syst Neurosci 2022 4;16:854874. Epub 2022 May 4.

VA Portland Health Care System, Portland, OR, United States.

Study Objectives: Traumatic brain injury (TBI) is associated with chronic sleep disturbances and cognitive impairment. Our prior preclinical work demonstrated dietary supplementation with branched chain amino acids (BCAA: leucine, isoleucine, and valine), precursors to glutamate production, restored impairments in glutamate, orexin/hypocretin neurons, sleep, and memory in rodent models of TBI. This pilot study assessed the feasibility and preliminary efficacy of dietary supplementation with BCAA on sleep and cognition in Veterans with TBI. Read More

Curr Phys Med Rehabil Rep 2022 May 14:1-6. Epub 2022 May 14.

Department of Rehabilitation Medicine, Joe R. and Teresa Lozano Long School of Medicine at the University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., MC7798, San Antonio, TX 78229 USA.

Purpose Of Review: Extrapulmonary manifestations of COVID-19 are abundant, including after recovery of acute SARS-CoV-2 infection. This review seeks to explore the cognitive and neuropsychiatric manifestations of COVID-19 and post-acute sequelae of SARS-CoV-2 (PASC), including Long COVID syndromes. Furthermore, the review will discuss rehabilitation strategies for the emerging neurological consequences of COVID-19 to help those experiencing long-term effects of COVID-19. Read More

Front Med (Lausanne) 2022 6;9:868316. Epub 2022 May 6.

Department of Physical Therapy, Faculty of Medicine, University of Chile, Santiago, Chile.

Background: Patients with chronic obstructive pulmonary disease (COPD) have systemic damage secondary to the primary pulmonary impairment, expressed in impaired peripheral musculature and a deficit in postural control compared to healthy subjects. This study aimed to determine the effects of rehabilitation on balance in patients with COPD.

Methods: An exhaustive search was conducted in four databases (Pubmed, Cochrane Library, EMBASE, Web of Science). Read More

Front Hum Neurosci 2022 6;16:849481. Epub 2022 May 6.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

Objective: This study aims to explore the effect of integrating routine treatment with Tai Chi Chuan (TCC) intervention on the clinical symptom of patients with Chronic Obstructive Pulmonary Disease (COPD) from clinical and neurological perspectives.

Methods: Twenty patients with COPD were recruited for regular treatment combined with 8-week TCC rehabilitative practice. Clinical symptoms were evaluated by Chronic Obstructive Pulmonary Symptom Assessment Scale (CAT) and Modified Dyspnea Scale (mMRC) at baseline and after treatment. Read More

Evid Based Complement Alternat Med 2022 28;2022:4133237. Epub 2022 Mar 28.

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23, Back Road of Art Gallery, Dongcheng District, Beijing 100010, China.

Pulmonary rehabilitation (PR) has a curative effect in patients undergoing pneumonectomy for lung cancer. Nevertheless, the contribution of PR to the clinical status of patients with chronic obstructive pulmonary disease (COPD) undergoing lung resection has not been adequately elucidated. The aim of this systematic review of randomized and nonrandomized controlled trials was to appraise the impact of PR compared to conventional treatment based on postoperative clinical status in patients with lung cancer and COPD. Read More

Sport Sci Health 2022 May 15:1-11. Epub 2022 May 15.

Department of Biomedical Sciences, University of Padova, Padua, Italy.

Coronavirus disease 2019 (COVID-19) is a worldwide pandemic illness that is impacting the cardiovascular, pulmonary, musculoskeletal, and cognitive function of a large spectrum of the worldwide population. The available pharmacological countermeasures of these long-term effects of COVID-19 are minimal, while myriads of non-specific non-pharmacological treatments are emerging in the literature. In this complicated scenario, particular emphasis should be dedicated to specific exercise interventions tailored for subjects and athletes recovering from COVID-19. Read More

Zhongguo Fei Ai Za Zhi 2022 May;25(5):311-322

Department of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Background: m6A RNA methylation modification plays an important role in the occurrence and progression of lung cancer and regulates tumor immunity. Current studies mostly focus on the differential expression of some specific m6A effectors and infiltrating immune cell. m6A methylation modification is the result of mutual adjustment and balance between effectors, and changes in the expression of one or two effectors are far from enough to reflect the panorama of m6A methylation. Read More