4,225 results match your criteria Pulmonary Hypertension Secondary


False-positive troponin elevation due to an immunoglobulin-G-cardiac troponin T complex: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, St George's University Hospital, Blackshaw Road, London SW17 0QT, UK.

Background: Troponin is a crucial biomarker for the diagnosis of an acute coronary syndrome (ACS). It rises in response to myocardial injury from significant acute myocardial ischaemia caused by obstructive coronary artery disease ['classical' myocardial infarction (MI)]. However, raised levels have also been noted in conditions not recognized as classical ACS. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319834PMC

Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference.

Eur J Intern Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Pharmacy; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States.

Background: Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Quality improvement has been identified as an important goal in the care of patients with AKI. Different settings can be targeted to improve AKI care, broadly classified these include the inpatient and outpatient environments. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.04.056DOI Listing

National trends and inpatient outcomes of pulmonary arterial hypertension related hospitalizations - Analysis of the National Inpatient Sample Database.

Int J Cardiol 2020 Jun 27. Epub 2020 Jun 27.

Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, United States.

Background: Pulmonary arterial hypertension (PAH) is associated with a significant burden of morbidity and mortality. We examined national trends in PAH-related hospitalizations, associated inpatient mortality (IM), length of stay (LOS) and hospitalization charges from 2007 to 2016, as well as predictors of IM and LOS in this population.

Methods: We used the National Inpatient Sample to identify PAH admissions using International classification of diseases (ICD) codes 416. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.036DOI Listing

Expression of ApoA5 and its function in the right ventricular failing and remodeling secondary to pulmonary hypertension.

J Cell Physiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiovascular Medicine, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Right heart failure and right ventricular (RV) remodeling were the main reason for mortality of pulmonary hypertension (PH) patients. Apolipoprotein AV (ApoA5) is a key regulator of plasma triglyceride and have multifunction in several target organs. We detected decreased ApoA5 in serum of patients with PH and both in serum and RV of monocrotaline-induced PH model. Read More

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http://dx.doi.org/10.1002/jcp.29911DOI Listing
June 2020
3.839 Impact Factor

New onset severe right ventricular failure associated with COVID-19 in a young infant without previous heart disease.

Cardiol Young 2020 Jun 16:1-4. Epub 2020 Jun 16.

Division of Radiology, Puerta del Mar University Hospital, Cadiz, Spain.

We present our recent experience with a 6-month-old infant with a personal history of short bowel syndrome that presented with fever, cyanosis, and cardiogenic shock secondary to severe pulmonary hypertension and right ventricular failure without pulmonary thromboembolism. He did not present signs of toxin-mediated disease or Kawasaki disease. He was finally diagnosed with SARS-CoV-2 infection. Read More

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http://dx.doi.org/10.1017/S1047951120001857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324758PMC

Acute Kidney Injury in Patients Undergoing Cardiopulmonary Bypass for Lung Transplantation.

J Surg Res 2020 Jun 26;255:332-338. Epub 2020 Jun 26.

Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Cardiopulmonary bypass (CPB) is often used to support patients undergoing lung transplantation who are intolerant of anatomic manipulation or single lung ventilation during the procedure. However, CPB may be associated with adverse outcomes. We evaluated the hypothesis that CPB is associated with increased acute kidney injury (AKI) and postoperative mortality after lung transplantation. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.072DOI Listing

ProT-α gene transfer attenuates cardiopulmonary remedying and mortality in a flow-induced pulmonary hypertension rat model.

J Heart Lung Transplant 2020 Jun 6. Epub 2020 Jun 6.

Department of Anesthesiology, E-Da Hospital/I-Shou University, Kaohsiung city, Taiwan. Electronic address:

Background: ProT is a cell survival gene, which modulates oxidative stress and transforming growth factor (TGF)-β signaling. We hypothesized that the delivery of the ProT cDNA gene in rats could protect against right heart dysfunction secondary to pulmonary hypertension (PH) induced by left-to-right shunt.

Methods: A 2-hit rat model of flow-induced PH was used, and a single intravenous injection of adenoviral vectors (2 billion plaque-forming unit) carrying ProT or Luc gene was administered. Read More

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http://dx.doi.org/10.1016/j.healun.2020.05.017DOI Listing

A review of cardiac manifestations and predictors of outcome in patients with COVID - 19.

Heart Lung 2020 May 3. Epub 2020 May 3.

Fellow in Department of Pulmonology and Critical Care Medicine, Mayo Clinic, Rochester, USA. Electronic address:

Coronavirus disease (COVID-19) pandemic has so far involved 184 countries and more than 2.79 million patients worldwide. Over the past three months, it has attributed to more than 196,000 deaths, with more than 50,000 deaths in the United States alone. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2020.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196397PMC

Revascularization may accelerate renal dysfunction in hypertensive patients with moderate atherosclerotic stenosis of renal arteries.

Med Hypotheses 2020 Jun 19;144:110008. Epub 2020 Jun 19.

Department of Cardiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address:

Atherosclerotic renal artery stenosis (ARAS) accounts for more than 90% of cases with renal artery stenosis, which is the recognized cause of secondary hypertension, renal dysfunction and acute pulmonary edema. It is estimated that about 15% of patients with hypertension also have different degrees of ARAS at the same time. Hypertension is known to be associated with the risk of atherosclerotic vascular disease; these two conditions usually co-exist and interact with each other. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.110008DOI Listing

CytoResc - "CytoSorb" Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial.

Trials 2020 Jun 26;21(1):577. Epub 2020 Jun 26.

Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: Approximately 8 - 10 % of COVID-19 patients present with a serious clinical course and need for hospitalization, 8% of hospitalized patients need ICU-treatment. Currently, no causal therapy is available and treatment is purely supportive. The main reason for death in critically ill patients is acute respiratory failure. Read More

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http://dx.doi.org/10.1186/s13063-020-04501-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316574PMC

How should we define appropriate patients for percutaneous transluminal renal angioplasty treatment?

Hypertens Res 2020 Jun 22. Epub 2020 Jun 22.

Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan.

Renovascular hypertension (RVH) is one of the most common causes of secondary hypertension and can result in resistant hypertension. RVH is associated with an increased risk for progressive decline in renal function, cardiac destabilization syndromes including "flash" pulmonary edema, recurrent congestive heart failure, and cerebrocardiovascular disease. The most common cause of renal artery stenosis (RAS) is atherosclerotic lesions, followed by fibromuscular dysplasia. Read More

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http://dx.doi.org/10.1038/s41440-020-0496-zDOI Listing

Intravenous iron and chronic obstructive pulmonary disease: a randomised controlled trial.

BMJ Open Respir Res 2020 Jun;7(1)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

Background: Increased iron availability modifies cardiorespiratory function in healthy volunteers and improves exercise capacity and quality of life in patients with heart failure or pulmonary hypertension. We hypothesised that intravenous iron would produce improvements in oxygenation, exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD).

Methods: We performed a randomised, placebo-controlled, double-blind trial in 48 participants with COPD (mean±SD: age 69±8 years, haemoglobin 144. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311010PMC

Outcomes of endotracheal suctioning in non-vigorous neonates born through meconium-stained amniotic fluid: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2020 Jun 19. Epub 2020 Jun 19.

Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.

Objective: We aimed to systematically review and analyse the outcomes of non-endotracheal suctioning (non-ETS) versus ETS in non-vigorous meconium-stained neonates.

Design: We conducted a systematic review of non-ETS and ETS in non-vigorous infants born through meconium-stained amniotic fluid (MSAF). We searched PubMed/Medline, Scopus, Clinical Trials. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318941DOI Listing
June 2020
3.120 Impact Factor

Incidence, Predictors, Causes, and Cost of 30-Day Hospital Readmission in Chronic Obstructive Pulmonary Disease Patients Undergoing Bronchoscopy.

Cureus 2020 Jun 13;12(6):e8607. Epub 2020 Jun 13.

Pulmonary Medicine, Interfaith Medical Center, Brooklyn, USA.

Introduction Chronic obstructive pulmonary disease (COPD) has a significant disease burden and is among the leading causes of hospital readmissions, adding a significant burden on healthcare resources. The association between 30-day readmission in a COPD patient undergoing bronchoscopy and a wide range of modifiable potential risk factors, after adjusting for sociodemographic and clinical factors, has been assessed, and comparison has been made with COPD patients not undergoing bronchoscopy. Methods We conducted a comprehensive analysis of the 2016 Nationwide Readmission Database (NRD) of 30-day all-cause readmission among COPD patients undergoing bronchoscopy. Read More

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http://dx.doi.org/10.7759/cureus.8607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294856PMC

Multi-parametric system for risk stratification in mitral regurgitation: a multi-task Gaussian prediction approach.

Eur J Clin Invest 2020 Jun 14:e13321. Epub 2020 Jun 14.

School of Data Science, City University of Hong Kong, Hong Kong, SAR, P.R. China.

Background: We hypothesized that a multiparametric approach incorporating medical co-morbidity information, electrocardiographic P-wave indices, echocardiographic assessment, neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) calculated from laboratory data, can improve risk stratification in mitral regurgitation (MR).

Methods: Patients diagnosed with mitral regurgitation between 1 March 2005 and 30 October 2018 from a single center were retrospectively analyzed. Outcomes analyzed were incident atrial fibrillation (AF), transient ischemic attack (TIA)/stroke and mortality. Read More

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http://dx.doi.org/10.1111/eci.13321DOI Listing

Efficacy and safety of renal denervation in addition to pulmonary vein isolation for atrial fibrillation and hypertension-Systematic review and meta-analysis of randomized controlled trials.

J Arrhythm 2020 Jun 27;36(3):386-394. Epub 2020 Apr 27.

Department of Cardiology and Vascular Medicine Faculty of Medicine Universitas Indonesia National Cardiovascular Center Harapan Kita Jakarta Indonesia.

Introduction: This systematic review and meta-analysis aimed to assess the latest evidence on the use of renal denervation (RDN) + pulmonary vein isolation (PVI) compared to PVI alone for treating atrial fibrillation (AF) with hypertension.

Methods: A systematic literature search from several electronic databases was performed up until January 2020. The primary outcome was AF recurrence defined as AF/atrial flutter (AFL)/atrial tachycardia (AT) ≥30 seconds at 12-month follow-up and the secondary outcome was procedure-related complications. Read More

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http://dx.doi.org/10.1002/joa3.12353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279983PMC

Non-Vitamin K Oral Anticoagulants in Adults with Congenital Heart Disease: A Systematic Review

J Clin Med 2020 06 9;9(6). Epub 2020 Jun 9.

First Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, 54 636 Thessaloniki, Greece.

Adults with congenital heart disease (ACHD) experience more thromboembolic complications than the general population. We systematically searched and critically appraised all studies on the safety and efficacy of non-vitamin-K oral anticoagulants (NOACs) in adult patients with various forms of congenital heart disease. PubMed and the Cochrane Central Register of Controlled Trials (CENTRAL) were used, with duplicate extraction of data and risk of bias assessment. Read More

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http://dx.doi.org/10.3390/jcm9061794DOI Listing

Clinical and diagnostic imaging findings in 37 rescued dogs with heartworm disease in Germany.

Authors:
Imke Maerz

Vet Parasitol 2020 May 30;283:109156. Epub 2020 May 30.

Tierklinik Hofheim GbR, Katharina Kemmler Straße 7, 65719, Hofheim am Taunus, Germany. Electronic address:

Canine dirofilariasis is currently uncommon in Germany, but its prevalence appears to be increasing due to rehoming of dogs from endemic areas. As part of staging of the disease, this case series describes clinical, radiological and echocardiographic findings in 37 dogs tested positive for Dirofilaria immitis between October 2016 and January 2019. Clinical history revealed 12 (32 %) asymptomatic and 22 (59 %) symptomatic dogs, with most of the dogs showing exercise intolerance, coughing or breathlessness. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109156DOI Listing

Adult congenital heart disease and the COVID-19 pandemic.

Heart 2020 Jun 10. Epub 2020 Jun 10.

Department of Cardiology III - Adult Congenital and Valvular Heart Disease, University Hospital Muenster, Muenster, Germany.

Adults with congenital heart disease (ACHD) may be at high risk in the case of COVID-19. Due to the heterogeneity of ACHD and secondary complications, risk profiles are, however, not uniform. This document aims to give an overview of relevant data and outline our pragmatic approach to disease prevention and management. Read More

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http://dx.doi.org/10.1136/heartjnl-2020-317258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299644PMC

The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial.

Trials 2020 Jun 8;21(1):498. Epub 2020 Jun 8.

Instituto de Salud Global de Barcelona, Barcelona, Spain.

Objectives: The primary objective is to determine the efficacy of a single dose of ivermectin, administered to low risk, non-severe COVID-19 patients in the first 48 hours after symptom onset to reduce the proportion of patients with detectable SARS-CoV-2 RNA by Polymerase Chain Reaction (PCR) test from nasopharyngeal swab at day 7 post-treatment. The secondary objectives are: 1.To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab at day 7 post treatment. Read More

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http://dx.doi.org/10.1186/s13063-020-04421-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276958PMC

Pumpless Lung Assist as a Bridge to Medical Therapy in a Teenager with Pulmonary Arterial Hypertension and Partial Anomalous Pulmonary Venous Return.

Can J Cardiol 2020 Jun 5. Epub 2020 Jun 5.

Departments of cardiac, thoracic and vascular surgery, centre de référence de l'Hypertension Artérielle Pulmonaire Sévère, groupe hospitalier Paris Saint-Joseph, hôpital Marie Lannelongue, Plessis-Robinson, Faculté de Médecine Paris-Saclay, Université Paris Sud, France; UMR-S 999, Inserm, France.

Heart failure is the main cause of death in patients with pulmonary arterial hypertension and congenital heart disease. We used an original approach in a 15-year-old girl with rapidly progressive right heart failure secondary to severe PAH and partial anomalous pulmonary venous return. After surgical CHD repair on cardiopulmonary bypass, she was weaned off bypass using a central Novalung® for 11 days then started on triple specific pulmonary vasodilator therapy. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.001DOI Listing

The tricuspid annular plane systolic excursion to systolic pulmonary artery pressure index: Association with all-cause mortality in patients with moderate or severe tricuspid regurgitation.

Int J Cardiol 2020 Jun 5. Epub 2020 Jun 5.

Cardiothoracic Centre, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.

Background: In patients with significant tricuspid regurgitation (TR) the conventional markers for the assessment of right ventricular (RV) systolic function may be less accurate. Tricuspid annular plane systolic excursion (TAPSE) indexed to systolic pulmonary artery pressure (SPAP) (TAPSE/SPAP) may be prognostically useful in pulmonary hypertension and left ventricular dysfunction. Our aim was to explore its use in patients with moderate or severe TR. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.05.093DOI Listing

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study.

medRxiv 2020 Apr 20. Epub 2020 Apr 20.

Background: Nearly 30,000 patients with coronavirus disease-2019 (COVID-19) have been hospitalized in New York City as of April 14th, 2020. Data on the epidemiology, clinical course, and outcomes of critically ill patients with COVID-19 in this setting are needed.

Methods: We prospectively collected clinical, biomarker, and treatment data on critically ill adults with laboratory-confirmed-COVID-19 admitted to two hospitals in northern Manhattan between March 2nd and April 1st, 2020. Read More

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http://dx.doi.org/10.1101/2020.04.15.20067157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276994PMC

Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension.

J Vet Intern Med 2020 Jun 5. Epub 2020 Jun 5.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Background: The clinical relevance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension (PH) is unknown.

Objective: To determine if echocardiographic measurements of right heart size and right ventricular (RV) function are associated with survival times in dogs with PH.

Animals: Eighty-two client-owned dogs. Read More

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http://dx.doi.org/10.1111/jvim.15826DOI Listing

"Pure" severe aortic stenosis without concomitant valvular heart diseases: echocardiographic and pathophysiological features.

Int J Cardiovasc Imaging 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, University Hospital Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Purpose: In echocardiography the severity of aortic stenosis (AS) is defined by effective orifice area (EOA), mean pressure gradient (mPG) and transvalvular flow velocity (maxV). The hypothesis of the present study was to confirm the pathophysiological presence of combined left ventricular hypertrophy (LVH), diastolic dysfunction (DD) and pulmonary artery hypertension (PAH) in patients with "pure" severe AS.

Methods And Results: Patients (n = 306) with asymptomatic (n = 133) and symptomatic (n = 173) "pure" severe AS (mean age 78 ± 9. Read More

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http://dx.doi.org/10.1007/s10554-020-01907-4DOI Listing

Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial.

Trials 2020 Jun 3;21(1):462. Epub 2020 Jun 3.

Wellcome Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science Queen's University Belfast, Belfast, UK.

Objectives: The primary objective of the study is to assess the safety of a single intravenous infusion of Mesenchymal Stromal Cells (MSCs) in patients with Acute Respiratory Distress Syndrome (ARDS) due to COVID-19. Secondary objectives are to determine the effects of MSCs on important clinical outcomes, as described below.

Trial Design: REALIST COVID 19 is a randomised, placebo-controlled, triple blinded trial. Read More

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http://dx.doi.org/10.1186/s13063-020-04416-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267756PMC

Severe pain-related adverse events of percutaneous dilatational tracheostomy performed by a neurointensivist compared with conventional surgical tracheostomy in neurocritically ill patients.

BMC Neurol 2020 Jun 3;20(1):223. Epub 2020 Jun 3.

Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: We evaluated severe pain-related adverse events (SAE) during the percutaneous dilatational tracheostomy (PDT) procedure performed by a neurointensivist and compared the outcomes with that of conventional surgical tracheostomy in neurocritically ill patients.

Methods: This was a retrospective and observational study of adult patients who were admitted to the neurosurgical intensive care unit between January 2014 and March 2018 and underwent tracheostomy. In this study, primary endpoints were incidence of SAE: cardiac arrest, arrhythmias, hypertension, hypotension, desaturation, bradypnea, or ventilatory distress. Read More

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http://dx.doi.org/10.1186/s12883-020-01809-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267757PMC
June 2020
2.040 Impact Factor

Interleukin-32 in systemic sclerosis, a potential new biomarker for pulmonary arterial hypertension.

Arthritis Res Ther 2020 06 1;22(1):127. Epub 2020 Jun 1.

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Background: Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great value to improve current diagnostic methods and develop new strategies for evaluating patients with suspected PAH. Read More

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http://dx.doi.org/10.1186/s13075-020-02218-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268373PMC

Effect of Vasopressin on Systemic and Pulmonary Hemodynamics in Neonates.

Am J Perinatol 2020 Jun 2. Epub 2020 Jun 2.

Division of Neonatology, Department of Pediatrics and Child Health, Max Rady Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Objective:  Despite its increasing use in neonates, the literature on the use of vasopressin (VP) in neonates is limited. The aim of this study is to evaluate the systemic and pulmonary effects of VP in neonates and to assess its safety among them.

Study Design:  This retrospective study enrolled all neonates in two level III neonatal intensive care units in Winnipeg, Manitoba, who had received VP therapy between 2011 and 2016. Read More

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http://dx.doi.org/10.1055/s-0040-1712999DOI Listing

Stenotrophomonas maltophilia Infection in a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD): A Colonizer or True Infection?

Am J Case Rep 2020 Jun 2;21:e924577. Epub 2020 Jun 2.

Department of Internal Medicine, Reading Hospital, Tower Health System, Reading, PA, USA.

BACKGROUND This article describes a finding of sputum culture positive for Stenotrophomonas maltophilia in an elderly woman with past medical history of chronic obstructive pulmonary disease (COPD) and hypertension, presenting with acute hypoxemic hypercapnic respiratory failure secondary to COPD exacerbation from bronchitis/bronchopneumonia. CASE REPORT Computed tomography (CT) of the chest showed secretions in the lower lobe bronchi and small scattered clustered nodules consistent with bronchitis/mild bronchopneumonia without evidence of pulmonary embolism. A sputum culture was positive for Stenotrophomonas maltophilia. Read More

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http://dx.doi.org/10.12659/AJCR.924577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295310PMC

Ebstein anomaly combined with unique pulmonary venous abnormality in a 9-month-old child.

Cardiol Young 2020 Jun 2:1-3. Epub 2020 Jun 2.

Division of Pediatric Cardiology, Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.

Ebstein anomaly is a rare CHD known for its wide spectrum of presentation with the age of diagnosis dependent on the malformation's severity. Here, the authors describe a case of delayed diagnosis of Ebstein anomaly, secondary to lack of medical attention, which resulted in severe tricuspid regurgitation and pulmonary hypertension. Furthermore, the case was complicated by a unique pulmonary venous abnormality. Read More

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http://dx.doi.org/10.1017/S1047951120001249DOI Listing

Refractory Acute Respiratory Distress Syndrome Secondary to COVID-19 Successfully Extubated to Average Volume-assured Pressure Support Non-invasive Ventilator.

Cureus 2020 Apr 27;12(4):e7849. Epub 2020 Apr 27.

Internal Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, West Virginia University, Morgantown, USA.

Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by the highly infectious novel SARS-CoV-2 coronavirus spread by droplet transmission. Consequently, the use of respiratory devices that may potentially promote aerosolization like non-invasive positive pressure ventilation (NIPPV) for diseases such as obstructive sleep apnea (OSA), advanced chronic obstructive lung disease, pulmonary hypertension (PH), and neuromuscular respiratory disease has been called into question. We present a case of a patient with history of OSA and PH convalescing from refractory acute respiratory distress syndrome (ARDS) secondary to COVID-19 who was successfully extubated to average volume-assured pressure support (AVAPS). Read More

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http://dx.doi.org/10.7759/cureus.7849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253078PMC

Comparison of Balloon Pulmonary Angioplasty and Pulmonary Vasodilators for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Meta-Analysis.

Sci Rep 2020 Jun 1;10(1):8870. Epub 2020 Jun 1.

Cardiovascular Division, University of Minnesota, Minneapolis, MN, USA.

Treatment options for chronic thromboembolic pulmonary hypertension (CTEPH) that is not amenable to thromboendarterectomy or is recurrent/persistent after thromboendarterectomy (inoperable CTEPH) include pulmonary vasodilators or balloon pulmonary angioplasty (BPA). We compared efficacy and safety outcomes of BPA with or without pulmonary vasodilators to pulmonary vasodilator therapy alone in patients with inoperable CTEPH. Observational and randomized trial data reporting outcomes for >5 patients with inoperable CTEPH were sought. Read More

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http://dx.doi.org/10.1038/s41598-020-65697-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264327PMC

The novel P2X7 receptor antagonist PKT100 improves cardiac function and survival in pulmonary hypertension by direct targeting of the right ventricle.

Am J Physiol Heart Circ Physiol 2020 Jul 29;319(1):H183-H191. Epub 2020 May 29.

Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

In pulmonary hypertension (PH) a proinflammatory milieu drives pulmonary vascular remodeling, maladaptive right ventricular (RV) remodeling, and right-sided heart failure. There is an unmet need for RV-targeted pharmaco-therapies to improve mortality. Targeting of the P2X7 receptor (P2X7R) reduces pulmonary pressures; however, its effects on the RV are presently unknown. Read More

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http://dx.doi.org/10.1152/ajpheart.00580.2019DOI Listing

MitraClip as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.

Eur Heart J Case Rep 2020 Feb 18;4(1):1-5. Epub 2020 Jan 18.

Division of Cardiology, Department of Heart Failure and Transplantation, Fundación Cardioinfantil, Universidad El Bosque, Calle 163A # 13B-60, Bogotá, Colombia.

Background: Patients with end-stage heart failure, suffering from severe pulmonary hypertension (PH) and elevated pulmonary vascular resistance, are not eligible for heart transplant due to high mortality risk and primary graft dysfunction. Severe PH may be favoured by functional severe mitral regurgitation, which is present in many cardiopathies like end-stage Chagasic cardiomyopathy.

Case Summary: We present a case of a young man with end-stage heart failure secondary to Chagas cardiomyopathy with severe functional mitral regurgitation (FMR) and severe PH. Read More

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http://dx.doi.org/10.1093/ehjcr/ytz238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245051PMC
February 2020

The COVID-19 Pandemic and its Impact on the Cardio-Oncology Population.

Curr Oncol Rep 2020 05 28;22(6):60. Epub 2020 May 28.

UCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, UCLA Medical Center, Los Angeles, CA, USA.

Purpose Of Review: The novel Coronavirus (2019-nCoV, COVID-19) is historically one of the most severe acute respiratory syndromes and pandemics to affect the globe in the twenty-first century. Originating in Wuhan, the virus rapidly spread and impacted subsets of populations with initial unclear risk factors contributing to worsening morbidity and mortality. Patients with diagnosis of cancer and undergoing treatment further represent a population at risk for worsening cardiopulmonary outcomes. Read More

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http://dx.doi.org/10.1007/s11912-020-00945-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253235PMC

A Tale of Three Rarities: Secondary Amyloid A (AA) Amyloidosis Caused by Recurrent Sialadenitis and Complicated by Pulmonary Hypertension and Adrenal Insufficiency.

Cureus 2020 Apr 23;12(4):e7792. Epub 2020 Apr 23.

Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

A 48-year-old lady presented with a parotid mass found to be secondary to recurrent sialadenitis. She was also found to have microcytic anemia, renal dysfunction, an elevated gamma gap, and an isolated alkaline phosphatase elevation. Later, she developed altered mental status and shock, and was found to have adrenal insufficiency, pulmonary hypertension, and pulmonary nodules. Read More

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http://dx.doi.org/10.7759/cureus.7792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243608PMC

Effects of levosimendan on weaning and survival in adult cardiogenic shock patients with veno-arterial extracorporeal membrane oxygenation: systematic review and meta-analysis.

Perfusion 2020 May 24:267659120918473. Epub 2020 May 24.

Cardiac Surgery Department, Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.

Introduction: Veno-arterial extracorporeal membrane oxygenation may be used to support patients with refractory cardiogenic shock. Many patients can be successfully weaned, the ability of some medications to facilitate weaning from veno-arterial extracorporeal membrane oxygenation were reported. To date, there are limited studies investigating the impact of levosimendan on veno-arterial extracorporeal membrane oxygenation weaning. Read More

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http://dx.doi.org/10.1177/0267659120918473DOI Listing

Evidence Base of Clinical Studies on Qi Gong: A Bibliometric Analysis.

Complement Ther Med 2020 May 6;50:102392. Epub 2020 Apr 6.

Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China; Institute of Integrated Traditional Chinese Medicine and Western Medicine, Guangzhou Medical University, Guangzhou, China. Electronic address:

Objective: This bibliometric study aimed to systematically and comprehensively summarize the volume, breadth and evidence for clinical research on Qigong. And this bibliometric analysis also can provide the evidence of this field.

Design: Bibliometric analysis. Read More

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http://dx.doi.org/10.1016/j.ctim.2020.102392DOI Listing

Mitral regurgitation and dyspnoea: the expanding role of mitral effective regurgitant orifice among un-selected patients.

J Cardiovasc Med (Hagerstown) 2020 Jul;21(7):503-509

Section of Cardiology, Department of Medicine, University of Verona, Verona, Italy.

Aims: Mitral regurgitation is frequent in the general population and among suspected heart failure patients; however, to what extent it contributes to dyspnoea is unclear. We hypothesized mitral regurgitation to have a role in determining dyspnoea in unselected ambulatory patients.

Methods: Consecutive outpatients referred for echocardiography were retrospectively screened and included. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000975DOI Listing

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study.

Lancet 2020 06 19;395(10239):1763-1770. Epub 2020 May 19.

Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital, New York, NY, USA; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address:

Background: Over 40 000 patients with COVID-19 have been hospitalised in New York City (NY, USA) as of April 28, 2020. Data on the epidemiology, clinical course, and outcomes of critically ill patients with COVID-19 in this setting are needed.

Methods: This prospective observational cohort study took place at two NewYork-Presbyterian hospitals affiliated with Columbia University Irving Medical Center in northern Manhattan. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)31189-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237188PMC

Contemporary usefulness of pulmonary venous flow parameters to estimate left ventricular end-diastolic pressure on transthoracic echocardiography.

Int J Cardiovasc Imaging 2020 May 21. Epub 2020 May 21.

Department of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Research and Training Hospital, Istanbul, Turkey.

Measurement of pulmonary venous flow (PVF) parameters can be used to estimate left ventricular end-diastolic pressure (LVEDP) on transthoracic echocardiography. Despite that, 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) algorithm gave a secondary role to PVF to assess left ventricular filling pressure. We aimed to test correlations between several PVF parameters, including novel measurements, with LVEDP and to analyze whether PVF parameters have an incremental usefulness over ASE/EACVI algorithm to estimate LVEDP. Read More

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http://dx.doi.org/10.1007/s10554-020-01886-6DOI Listing

Chronic thromboembolic pulmonary hypertension secondary to implantable cardioverter defibrillator lead thrombus in a patient with Brugada syndrome: a rare complication requiring a multidisciplinary approach.

BMJ Case Rep 2020 May 19;13(5). Epub 2020 May 19.

Pulmonary Hypertension Unit, Department of Cardiology, Hospital Garcia de Orta, Almada, Portugal.

We report the case of a 57-year-old male patient with prior syncope associated with sustained ventricular tachycardia in the setting of Brugada syndrome, who was submitted to implantation of a cardioverter defibrillator for secondary prevention. During follow-up, he presented a significant increase in lead impedance, and a transthoracic echocardiogram showed a mass attached to the lead. He was started on oral anticoagulation after infective endocarditis was excluded but nevertheless suffered repeated episodes of pulmonary embolism that led to severe chronic thromboembolic pulmonary hypertension. Read More

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http://dx.doi.org/10.1136/bcr-2020-234549DOI Listing

Supervised pulmonary hypertension exercise rehabilitation (SPHERe): study protocol for a multi-centre randomised controlled trial.

BMC Pulm Med 2020 May 19;20(1):143. Epub 2020 May 19.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.

Background: Supervised cardio-pulmonary rehabilitation may be safe and beneficial for people with pulmonary hypertension (PH) in groups 1 (pulmonary arterial hypertension) and 4 (chronic thromboembolic disease), particularly as a hospital in-patient. It has not been tested in the most common PH groups; 2 (left heart disease), 3 (lung disease), or 5 (other disorders). Further it has not been evaluated in the UK National Health Service (NHS) out-patient setting, or with long-term follow-up. Read More

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http://dx.doi.org/10.1186/s12890-020-01182-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236437PMC

Demographics and Outcomes of Pulmonary Hypertension Patients in United States Emergency Departments.

West J Emerg Med 2020 Apr 16;21(3):714-721. Epub 2020 Apr 16.

Massachusetts General Hospital, Department of Emergency Medicine, Boston, Massachusetts.

Introduction: Pulmonary hypertension (PH) is a common, yet under-diagnosed, contributor to morbidity and mortality. Our objective was to characterize the prevalence of PH among adult patients presenting to United States (US) emergency departments (ED) and to identify demographic patterns and outcomes of PH patients in the ED.

Methods: We analyzed the Nationwide Emergency Department Sample (NEDS) database, with a focus on ED patients aged 18 years and older, with any International Classification of Diseases, Clinical Modification (ICD)-9-CM or ICD-10-CM diagnosis code for PH from 2011 to 2015. Read More

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http://dx.doi.org/10.5811/westjem.2020.2.45187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234722PMC

Bevacizumab plus chemotherapy in nonsquamous non-small cell lung cancer patients with malignant pleural effusion uncontrolled by tube drainage or pleurodesis: A phase II study North East Japan Study group trial NEJ013B.

Thorac Cancer 2020 Jul 18;11(7):1876-1884. Epub 2020 May 18.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Pleurodesis is the standard of care for non-small cell lung cancer (NSCLC) patients with symptomatic malignant pleural effusion (MPE). However, there is no standard management for MPE uncontrolled by pleurodesis. Most patients with unsuccessful MPE control are unable to receive effective chemotherapy. Read More

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http://dx.doi.org/10.1111/1759-7714.13472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327672PMC

Chronic cigarette smoke exposure triggers a vicious cycle of leukocyte and endothelial-mediated oxidant stress that results in vascular dysfunction.

Am J Physiol Heart Circ Physiol 2020 Jul 15;319(1):H51-H65. Epub 2020 May 15.

Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio.

Although there is a strong association between cigarette smoking exposure (CSE) and vascular endothelial dysfunction (VED), the underlying mechanisms by which CSE triggers VED remain unclear. Therefore, studies were performed to define these mechanisms using a chronic mouse model of cigarette smoking (CS)-induced cardiovascular disease mirroring that in humans. C57BL/6 male mice were subjected to CSE for up to 48 wk. Read More

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http://dx.doi.org/10.1152/ajpheart.00657.2019DOI Listing

Challenges and Special Aspects of Pulmonary Hypertension in Middle- to Low-Income Regions: JACC State-of-the-Art Review.

J Am Coll Cardiol 2020 May;75(19):2463-2477

Department of Pediatric Cardiology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Challenges and special aspects related to the management and prognosis of pulmonary hypertension (PH) in middle- to low-income regions (MLIRs) range from late presentation to comorbidities, lack of resources and expertise, cost, and rare options of lung transplantation. Expert consensus recommendations addressing the specific challenges for prevention and therapy of PH in MLIRs with limited resources have been lacking. To date, 6 MLIR-PH registries containing mostly adult patients with PH exist. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.03.047DOI Listing

[COVID-19 associated pneumonia despite repeatedly negative PCR-analysis from oropharyngeal swabs].

Dtsch Med Wochenschr 2020 06 13;145(12):844-849. Epub 2020 May 13.

Klinik für Innere Medizin II, Gastroenterologie, Hepatologie, Endokrinologie und Infektiologie, Universitätsklinikum Freiburg.

Patient History And Clinical Findings: A 46-year old construction worker presented at the emergency department with two orthostatic syncopes. The patient complained of prolonged fever and coughs for 7 days which had not improved after oral treatment with sultamicillin for 5 days, prescribed by the patient's general practitioner. Physical examination showed high blood pressure due to previously known hypertension. Read More

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http://dx.doi.org/10.1055/a-1170-6061DOI Listing

Early postnatal changes of circulating N-terminal-pro-B-type natriuretic peptide in neonates with congenital diaphragmatic hernia.

Early Hum Dev 2020 Jul 25;146:105049. Epub 2020 Apr 25.

Department of Neonatology and Pediatric Intensive Care Medicine, University of Bonn, Germany. Electronic address:

Background: Severity of lung hypoplasia, pulmonary hypertension (PH) and cardiac dysfunction are major contributors to mortality in congenital diaphragmatic hernia (CDH). Therefore, early assessment and management is important to improve outcome. NT-proBNP is an established cardiac biomarker with only limited data for early postnatal risk assessment in CDH newborns. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2020.105049DOI Listing
July 2020
1.931 Impact Factor