3,859 results match your criteria Pulmonary Hypertension Secondary


Differences in clinical characteristics and one-year outcomes of hospitalized heart failure patients in succeeding European Society of Cardiology-Heart Failure Registries - Pilot and Long-Term.

Pol Arch Intern Med 2019 Jan 16. Epub 2019 Jan 16.

INTRODUCTION The management of heart failure (HF) has significantly changed in recent decades. OBJECTIVES The paper analyzes clinical profile, one-year outcomes, predictors of mortality and hospital readmissions in hospitalized patients enrolled in the European Society of Cardiology HF-Pilot (ESC-HF-Pilot) and HF-Long Term (ESC-HF-LT) Registries. PATIENTS AND METHODS The analysis included hospitalized Polish patients from the ESC-HF-Pilot and ESC-HF-LT Registries. Read More

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http://dx.doi.org/10.20452/pamw.4418DOI Listing
January 2019

Impact of preoperative pulmonary arterial hypertension on early and late outcomes in patients undergoing valve surgery for rheumatic heart disease.

Indian J Anaesth 2018 Dec;62(12):963-971

Department of Cardiac Anesthesia, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India.

Background And Aims: There is conflicting evidence on adverse effect of Pulmonary Arterial Hypertension (PAH) on outcomes after cardiac surgery for rheumatic heart disease (RHD). The authors studied Indian patients with RHD and preoperative PAH, who undergo cardiac surgery with a hypothesis that they have poor short and long-term outcomes.

Methods: This was a retrospective observational study of 407 patients. Read More

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http://dx.doi.org/10.4103/ija.IJA_374_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299764PMC
December 2018

Effect of pulmonary artery denervation in postcapillary pulmonary hypertension: results of a randomized controlled translational study.

Basic Res Cardiol 2019 Jan 11;114(2). Epub 2019 Jan 11.

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

There is scarce evidence for pulmonary artery denervation (PADN) as a potential treatment for chronic postcapillary pulmonary hypertension (PH). We aimed to perform a proof-of-concept of PADN in a translational model of chronic PH. Nineteen pigs with chronic postcapillary PH (secondary to pulmonary vein banding) were randomized to surgical-PADN (using bipolar radiofrequency clamps) or sham procedure. Read More

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http://dx.doi.org/10.1007/s00395-018-0714-xDOI Listing
January 2019

Long-Term Prognosis of Patients with Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension: CSTAR-PAH Cohort Study.

Eur Respir J 2019 Jan 11. Epub 2019 Jan 11.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China

This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with SLE-associated PAH confirmed by right heart catheterisation. A multicenter prospective cohort of SLE-associated PAH was established. Baseline and follow-up records were collected. Read More

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http://dx.doi.org/10.1183/13993003.00081-2018DOI Listing
January 2019
1 Read
7.636 Impact Factor

Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial.

Nitric Oxide 2019 Jan 8. Epub 2019 Jan 8.

Associate Professor of Medicine, Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Indiana University School of Medicine, USA.

Objective: To test the hypothesis that adjunctive inhaled NO would improve RV function and viability in acute PE.

Methods: This was a randomized, placebo-controlled, double blind trial conducted at four academic hospitals. Eligible patients had acute PE without systemic arterial hypotension but had RV dysfunction and a treatment plan of standard anticoagulation. Read More

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http://dx.doi.org/10.1016/j.niox.2019.01.006DOI Listing
January 2019

Successful Treatment of Refractory Massive Pulmonary Embolism with Repeated Administration of Systemic Thrombolysis.

Tanaffos 2018 Feb;17(2):127-131

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: We report a case series of two patients in the intensive care unit with massive pulmonary embolism and obstructive shock who had resolution of shock after repeated administration of alteplase.

Case Summaries: Both patients were initially dosed 10 mg of alteplase followed by infusion of 90 mg over 2 hours, but remained in obstructive shock requiring significant inotropic and vasopressor support. Both patients were deemed poor candidates for embolectomy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320563PMC
February 2018
1 Read

Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.

Arterioscler Thromb Vasc Biol 2019 Jan 10:ATVBAHA118312280. Epub 2019 Jan 10.

From the Department of Pathophysiology, School of Basic Medicine (L.Z., R.X., X.Z., Y.Lang, F.L., Z.Y., S.L., Q.H.).

Objective- This study aims to determine whether and how the enriched metabolites of endothelial extracellular vesicles (eEVs) are critical for cigarette smoke-induced direct injury of endothelial cells and the development of pulmonary hypertension, rarely explored in contrast to long-investigated mechanisms secondary to chronic hypoxemia. Approach and Results- Metabonomic screen of eEVs from cigarette-smoking human subjects reveals prominent elevation of spermine-a polyamine metabolite with potent agonist activity for the extracellular CaSR (calcium-sensing receptor). CaSR inhibition with the negative allosteric modulator Calhex231 or CaSR knockdown attenuates cigarette smoke-induced pulmonary hypertension in rats without emphysematous changes in lungs or chronic hypoxemia. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312280DOI Listing
January 2019
3 Reads

Evaluating the effect of nasal septoplasty on atrial electromechanical features.

Am J Otolaryngol 2018 Dec 15. Epub 2018 Dec 15.

Otolaryngeaolgy, Duzce University Medical School, 81100 Duzce, Turkey.

Background: Recent studies have demonstrated that right ventricular (RV) dysfunction and increased pulmonary artery pressure may be frequent in patients with upper airway obstruction. In this study, we evaluated atrial conduction delays in patients with upper airway obstruction secondary to nasal septum deviation (NSD).

Methods: A total of 32 patients with upper airway obstruction secondary to NSD undergoing a septoplasty procedure were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.12.007DOI Listing
December 2018

Death or resolution: the "natural history" of pulmonary hypertension in bronchopulmonary dysplasia.

J Perinatol 2019 Jan 7. Epub 2019 Jan 7.

Pediatric Cardiology, Stanford University School of Medicine - Lucile Packard Children's Hospital, Stanford, Stanford, CA, USA.

Objectives: The primary objective was to describe the early "natural history" of pulmonary hypertension (PH) in the premature population. The secondary objective was to describe factors associated with poor outcomes in the premature population with PH at 36 weeks post-menstrual age (PMA).

Study Design: Retrospective chart review of patients followed at our institution from 2000 to 2017 with echocardiographic (ECHO) evidence of PH at 36 weeks PMA, and born ≤ 32 weeks estimated gestational age (GA). Read More

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http://dx.doi.org/10.1038/s41372-018-0303-8DOI Listing
January 2019

Rationale and design of TransplantLines: a prospective cohort study and biobank of solid organ transplant recipients.

BMJ Open 2018 Dec 31;8(12):e024502. Epub 2018 Dec 31.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Introduction: In the past decades, short-term results after solid organ transplantation have markedly improved. Disappointingly, this has not been accompanied by parallel improvements in long-term outcomes after transplantation. To improve graft and recipient outcomes, identification of potentially modifiable risk factors and development of biomarkers are required. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318532PMC
December 2018
2 Reads

Decreased biventricular longitudinal strain in patients with systemic sclerosis is mainly caused by pulmonary hypertension and not by systemic sclerosis per se.

Clin Physiol Funct Imaging 2018 Dec 31. Epub 2018 Dec 31.

Department of Clinical Sciences Lund, Clinical Physiology, Skåne University Hospital, Lund University, Lund, Sweden.

Purpose: Patients with pulmonary arterial hypertension (PAH) due to systemic sclerosis (SSc) have high mortality. Left ventricular (LV) peak global longitudinal strain (GLS) is decreased in SSc. It is unknown whether low GLS is due to SSc or PAH. Read More

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http://doi.wiley.com/10.1111/cpf.12561
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http://dx.doi.org/10.1111/cpf.12561DOI Listing
December 2018
1 Read

XANTUS-EL: A real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation in Eastern Europe, Middle East, Africa and Latin America.

Egypt Heart J 2018 Dec 24;70(4):307-313. Epub 2018 Sep 24.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: The prospective, observational XANTUS study demonstrated low rates of stroke and major bleeding in real-world rivaroxaban-treated patients with non-valvular atrial fibrillation (NVAF) from Western Europe, Canada and Israel. XANTUS-EL is a component of the overall XANTUS programme and enrolled patients with NVAF treated with rivaroxaban from Eastern Europe, the Middle East and Africa (EEMEA) and Latin America.

Methods: Patients with NVAF starting rivaroxaban for stroke prevention were consecutively recruited and followed for 1 year, at approximately 3-month intervals, or for ≥30 days after permanent rivaroxaban discontinuation. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303362PMC
December 2018

Evaluation of Macitentan in Patients With Eisenmenger Syndrome.

Circulation 2019 Jan;139(1):51-63

Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Italy (N.G.).

Background: Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macitentan in Eisenmenger Syndrome to Restore Exercise Capacity) evaluated the efficacy and safety of the endothelin receptor antagonist macitentan in patients with Eisenmenger syndrome.

Methods: Patients with Eisenmenger syndrome aged ≥12 years and in World Health Organization functional class II-III were randomized 1:1 to placebo or macitentan 10 mg once daily for 16 weeks. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033575DOI Listing
January 2019
1 Read

The prognostic value of various biomarkers in adults with pulmonary hypertension; a multi-biomarker approach.

Am Heart J 2018 Nov 24;208:91-99. Epub 2018 Nov 24.

Department of Cardiology, Erasmus Medical Centre, Rotterdam, the Netherlands. Electronic address:

Background: This study aimed to investigate the prognostic value of six different biomarkers in patients with pulmonary hypertension (PH) and to explore whether a multi-biomarker approach can contribute to a better risk stratification.

Methods: In this prospective study, patients with PH were included at the day of the diagnostic right heart catheterization between May 2012 and October 2016. Venous blood sampling included; NT-proBNP, high sensitive troponin-T, high sensitive CRP, galectin-3, red blood cell distribution width and eGFR. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.11.001DOI Listing
November 2018
1 Read

Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells.

Front Physiol 2018 6;9:1754. Epub 2018 Dec 6.

Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria.

Intermittent hypoxia is a major factor in clinical conditions like the obstructive sleep apnea syndrome or the cyclic recruitment and derecruitment of atelectasis in acute respiratory distress syndrome and positive pressure mechanical ventilation. investigations of the direct impact of intermittent hypoxia are frequently hampered by multiple co-morbidities of patients. Therefore, cell culture experiments are important model systems to elucidate molecular mechanisms that are involved in the cellular response to alternating oxygen conditions and could represent future targets for tailored therapies. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01754
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http://dx.doi.org/10.3389/fphys.2018.01754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291480PMC
December 2018
3 Reads

Clinical considerations when treating neonatal aspiration syndromes.

Expert Rev Respir Med 2018 Dec 20. Epub 2018 Dec 20.

c Clinic of Neonatology, Jessenius Faculty of Medicine , Comenius University and University Hospital Martin , Kollarova 2, 03601 Martin , Slovakia.

Introduction: In physiological conditions, neonatal airways are well-protected against aspiration of fluid or particulate material into the lungs, with laryngeal chemoreflex (LCR) being the most powerful mechanism. Failure of this protection allows substances to enter the lower airways, which starts a series of pathophysiological events initiated by inflammation and surfactant inactivation. The condition is defined as neonatal acute respiratory distress syndrome (ARDS), and its symptoms can range from mild respiratory distress to respiratory failure, often accompanied by persistent pulmonary hypertension (PPHN), in turn even leading to death. Read More

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https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
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http://dx.doi.org/10.1080/17476348.2019.1562340DOI Listing
December 2018
11 Reads

Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort.

Arthritis Res Ther 2018 Dec 19;20(1):280. Epub 2018 Dec 19.

Complexo Hospitalario Universitario de Vigo, Vigo, Spain.

Background: The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

Methods: All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology [SER], cross-sectional phase) registry were retrospectively investigated for the presence of primary pleuropulmonary manifestations.

Results: In total 3215 patients were included. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1776-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299951PMC
December 2018
5 Reads

Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism.

Circ Res 2018 Dec;123(12):e51-e64

From the Department of Biomedical Engineering (N.C.B., C.R.C., J.C.S., C.S., R.D., W.D.M.), Vanderbilt University Medical Center, Nashville, TN.

Rationale: Pulmonary arterial hypertension is a deadly disease of the pulmonary vasculature for which no disease-modifying therapies exist. Small-vessel stiffening and remodeling are fundamental pathological features of pulmonary arterial hypertension that occur early and drive further endovascular cell dysfunction. Bone marrow (BM)-derived proangiogenic cells (PACs), a specialized heterogeneous subpopulation of myeloid lineage cells, are thought to play an important role in pathogenesis. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309812PMC
December 2018
2 Reads

Resistant Hypertension From Renal Artery Stenosis Leading to Heart Failure With Preserved Ejection Fraction.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618816501. Epub 2018 Dec 7.

University of Alberta, Edmonton, Alberta, Canada.

Resistant hypertension remains an important cause of heart failure. In this article, we describe a case of resistant hypertension in a 63-year-old woman leading to heart failure and marked morbidity. Her clinical course was characterized by chronic pleural effusions and recurrent hospitalizations with respiratory failure and flash pulmonary edema associated with heart failure with preserved ejection fraction. Read More

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http://dx.doi.org/10.1177/2324709618816501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291873PMC
December 2018

Pulmonary vein thrombosis secondary to tuberculosis in a non-HIV infected patient.

Respir Med Case Rep 2019 5;26:91-93. Epub 2018 Dec 5.

Department of Internal Medicine, Marshall University School of Medicine and Huntington VAMC, Huntington, WV, USA.

Our patient is a 67-year-old male with a past medical history significant for hypertension and hyperlipidemia came to a hospital with hemoptysis. He was also having cough and shortness of breath for the last 1 month. He said that his hemoptysis was about 1 cup per day mixed with yellowish sputum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183036
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http://dx.doi.org/10.1016/j.rmcr.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288975PMC
December 2018
6 Reads

Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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http://link.springer.com/10.1007/s10995-018-2652-5
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http://dx.doi.org/10.1007/s10995-018-2652-5DOI Listing
December 2018
4 Reads

Characterization of Right Ventricular Deformation in Pulmonary Arterial Hypertension Using Three-Dimensional Principal Strain Analysis.

J Am Soc Echocardiogr 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada. Electronic address:

Background: Pulmonary arterial hypertension (PAH) can cause maladaptive right ventricular (RV) functional changes associated with adverse prognosis that are challenging to accurately quantify noninvasively. The aim of this study was to explore principal strain (PS) with contraction angle analysis using three-dimensional echocardiography to characterize RV deformation changes in patients with PAH.

Methods: Three-dimensional echocardiography was performed in 37 patients with PAH and 20 healthy control subjects with two-component (primary and secondary) PS and principal contraction angle analysis. Read More

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http://dx.doi.org/10.1016/j.echo.2018.10.001DOI Listing
December 2018
1 Read
4.056 Impact Factor

Pancreatic carcinoma underlying a complex presentation in late pregnancy: a case report.

J Med Case Rep 2018 Dec 15;12(1):369. Epub 2018 Dec 15.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, Parkville, Australia.

Background: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Read More

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http://dx.doi.org/10.1186/s13256-018-1911-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295019PMC
December 2018

Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Neonatology, Department of Paediatrics, CHU de Québec, Université Laval, Québec City, Québec, Canada.

Background:  Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% of neonatal respiratory insufficiency. To selectively reduce pulmonary vascular resistance, several treatments have been tried. Inhaled epoprostenol (iPGI) has been used for 12 years in our institution for the management of refractory PPHN despite the gaps in the literature to support this use. Read More

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http://dx.doi.org/10.1055/s-0038-1676483DOI Listing
December 2018
4 Reads

Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

Introduction: Our objective was to evaluate the pulmonary hypertension (PH) data for Spanish patients with systemic sclerosis (SSc), define the PH types and determine the associated factors.

Method: Descriptive study of PH-related data from the multicentre RESCLE registry. Estimated systolic pulmonary artery pressure (esPAP), measured via echocardiogram was considered elevated if ≥ 35 mmHg. Read More

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http://dx.doi.org/10.1007/s10067-018-4390-xDOI Listing
December 2018
1 Read
1.774 Impact Factor

Comparison of Inpatient and Outpatient Preoperative Factors and Postoperative Outcomes in 2-Level Cervical Disc Arthroplasty.

Neurospine 2018 Dec 9;15(4):376-382. Epub 2018 Sep 9.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Objective: The purpose of this study was to evaluate factors associated with inpatient admission following 2-level cervical disc arthroplasty (CDA). A secondary aim was to compare outcomes between those treated on an inpatient versus outpatient basis.

Methods: Using data from the American College of Surgeons National Surgical Quality Improvement Program database, multivariate logistic regression analysis was used to assess the independent effect of each variable on inpatient or outpatient selection for surgery. Read More

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http://dx.doi.org/10.14245/ns.1836102.051DOI Listing
December 2018

Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog.

Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.

Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More

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https://actavetscand.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13028-018-0433-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282261PMC
December 2018
6 Reads

[Multicenter investigation of extracorporeal membrane oxygenation application in pediatric intensive care unit in China].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):929-932

Department of Pediatric Emergency Medicine, Children's Hospital of Fudan University, Shanghai 201102, China.

To survey the conduction and evaluate the effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in pediatric intensive care unit (PICU) in China mainland. In a questionnaire-based survey, we retrospectively reviewed the application of ECMO in children's hospital and general hospital in China mainland to summarize and analyze the categories of diseases and prognosis of children treated with ECMO therapy. By December 31, 2017, a total of 23 hospitals using ECMO, including 22 tertiary referral hospitals and 1 secondary hospital, among which 16 were children's hospitals and 7 were general hospitals. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.12.008DOI Listing
December 2018
4 Reads

[THE STRUCTURE AND RISK OF CHRONIC MORBIDITY IN SOME VILLAGES OF THE UPPER IMERETI REGION OF WEST GEORGIA AND THEIR MOLECULAR AND CYTOGENETIC MARKERS].

Georgian Med News 2018 Oct(283):97-103

David the Builder University of Georgian; Tbilisi State Medical University; Beritashvili Center of Experimental Biomedicine; Sachkhere District Hospital, Georgia.

The purpose of our study was to identify the nature of the cause-effect relationship between the risks of developing of Chronic Obstructive Pulmonary Disease (COPD) and Cardio-vascular Disease (CVD) in patients residing in the villages of Chiatura district, characterized by varying degrees of environmental stress. The residents (n=400) of the Chiatura district living in the villages, Khreiti, Perevisa and Rgani were examined. The villages are characterized by different degrees of ecological tension (the villages differ both in their remoteness from sources of environmental pollution - manganese mining quarries and the scale of its extraction, which allows them to rank according to the degree of environmental tension: Khreiti - low, Perevis - medium, Rgani - high). Read More

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October 2018
8 Reads

Obesity in COPD: Comorbidities with Practical Consequences?

COPD 2018 Dec 4:1-8. Epub 2018 Dec 4.

a Department of Pulmonary Disease , Rijnstate hospital , Arnhem , Netherlands.

COPD and obesity often coexist and there is a complex interaction between them. Our aim was to evaluate the prevalence of obesity in a secondary care COPD population. Furthermore, the presence of comorbidities in obese (COPD) and non-obese COPD (COPD) individuals was studied. Read More

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https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1
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http://dx.doi.org/10.1080/15412555.2018.1509951DOI Listing
December 2018
8 Reads

Awakening the sleeping kidney in a dialysis-dependent patient with fibromuscular dysplasia: A case report and review of literature.

World J Nephrol 2018 Nov;7(7):143-147

Division of Nephrology, Department of Medicine, Tygerberg Hospital and Stellenbosch University, Cape Town 7505, South Africa.

Renal artery stenosis is a common cause of secondary hypertension and chronic kidney disease. We present here a case of fibromuscular dysplasia that was treated with surgical revascularization, resulting in recovery of kidney function with eventual cessation of chronic dialysis. The case involves a 25-year-old female with coincidentally discovered hypertension, who underwent further investigations revealing a diagnosis of renal artery stenosis due to fibromuscular dysplasia. Read More

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http://dx.doi.org/10.5527/wjn.v7.i7.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259034PMC
November 2018
4 Reads

Is pericardial effusion a negative prognostic marker? Meta-analysis of outcomes of pericardial effusion.

J Cardiovasc Med (Hagerstown) 2019 Jan;20(1):39-45

Cardiovascular and Thoracic Department and Department of Medical Sciences, University Cardiology, AOU Città della Salute e della Scienza di Torino, Torino, Italy.

Background: The prognostic relevance and the prevalence of pericardial effusion in several diseases are not well established. The aim of this meta-analysis is to summarize the available evidence related to pericardial effusion prevalence and outcomes according to the cause.

Methods: Articles investigating the prognosis of pericardial effusion were identified by literature search. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000720DOI Listing
January 2019
1 Read

[Etiological diagnosis of pulmonary hypertension: A cause of difficult diagnosis].

Rev Mal Respir 2018 Nov 22. Epub 2018 Nov 22.

Service de pneumologie de Louis-Pradel, centre national de référence des maladies pulmonaires rares, centre de compétence de l'hypertension pulmonaire, groupement hospitalier Est, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Université Claude-Bernard Lyon 1, 8, avenue Rockefeller, 69008, Lyon, France. Electronic address:

Introduction: Schistosomiasis associated pulmonary arterial hypertension belongs to group 1 of the pulmonary hypertension classification and should be considered in any patient with pulmonary hypertension returning from an endemic area.

Case Report: A 17-year-old patient was hospitalized for pulmonary hypertension detected during the initial assessment of viral hepatitis B-related cirrhosis with portal hypertension. The initial assessment established the diagnosis of pulmonary hypertension secondary to viral hepatitis B-cirrhosis. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.11.004DOI Listing
November 2018
5 Reads

Echocardiographic evaluation of prevalence of pulmonary hypertension in β-thalassemia major: A cross sectional study.

Pediatr Hematol Oncol 2018 Nov 23:1-9. Epub 2018 Nov 23.

c Oncology Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Introduction: Pulmonary hypertension is a common complication associated with thalassemia syndromes and it may play an important role in the pathogenesis of right ventricle failure. The true prevalence of pulmonary hypertension in patients with thalassemia major remains unclear and has been reported to be between 2 and 79%.

Materials And Methods: In total, 70 patients with thalassemia major were initially examined. Read More

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http://dx.doi.org/10.1080/08880018.2018.1534914DOI Listing
November 2018
8 Reads

Pulmonary thromboendarterectomy in a combined thrombophilia patient.

Cardiovasc J Afr 2018 Nov 20;29:1-3. Epub 2018 Nov 20.

Department of Cardiovascular Surgery, Faculty of Medicine, Bezmialem University, Istanbul, Turkey.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a potentially correctable cause of secondary pulmonary hypertension. Surgical treatment remains the primary treatment for patients with CTEPH. Pulmonary thromboendarterectomy (PEA) with deep hypothermic circulatory arrest is the standard and recommended surgical technique for the treatment of these patients. Read More

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http://dx.doi.org/10.5830/CVJA-2018-052DOI Listing
November 2018
6 Reads

Association Between Pulmonary Hypertension and Transcatheter Aortic Valve Replacement: Analysis of A Nationwide Inpatient Sample Database.

Rev Recent Clin Trials 2018 11 19. Epub 2018 Nov 19.

Department of Cardiology, St. Joseph Mercy Oakland Hospital, 44405 Woodward Ave, Pontiac, MI 48341. United States.

Introduction: This study was done to review the association of pulmonary hypertension (PH) with Transcatheter Aortic Valve Replacement (TAVR) procedures done in the US for years 2010 to 2012.

Methods: We used Nationwide Inpatient Sample (NIS) data to extract data for patients who were hospitalized with a primary/secondary diagnosis of TAVR as specified by International Classification of Disease (ICD-9) codes 35.05 and 35. Read More

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http://dx.doi.org/10.2174/1574887113666181120113034DOI Listing
November 2018
6 Reads

Frequency and etiology of pulmonary hypertension in patients with myeloproliferative neoplasms.

Eur J Haematol 2018 Nov 19. Epub 2018 Nov 19.

Department of Haematology, Odense University Hospital, Odense, Denmark.

Objective: Pulmonary hypertension (PH) has been reported to be associated with myeloproliferative neoplasms (MPN), affecting 5%-48% of MPN patients. With the aims to describe the prevalence of PH in Ph-MPN patients and explore the cause in identified subjects, we performed a prospective cohort study of Ph-MPN patients.

Method: Transthoracic echocardiography (TTE) was performed on all patients. Read More

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http://doi.wiley.com/10.1111/ejh.13197
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http://dx.doi.org/10.1111/ejh.13197DOI Listing
November 2018
9 Reads

Transplant options for end stage chronic obstructive pulmonary disease in the context of multidisciplinary treatments.

J Thorac Dis 2018 Oct;10(Suppl 27):S3356-S3365

Thoracic Surgery and Lung Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Lung transplantation (LTx) in advanced stage chronic obstructive pulmonary disease (COPD) patients is associated with significant improvement in lung function and exercise capacity. However, demonstration that the procedure also provides a survival benefit has been more elusive compared to other respiratory conditions. Identification of patients with increased risk of mortality is crucial: a low forced expiratory volume in 1 second (FEV) is perhaps the most common reason for referral to a lung transplant center, but in itself is insufficient to identify which COPD patients will benefit from LTx. Read More

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http://jtd.amegroups.com/article/view/21080/18463
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http://dx.doi.org/10.21037/jtd.2018.04.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204341PMC
October 2018
8 Reads

MicroRNA-21 is Associated with the Severity of Right Ventricular Dysfunction in Patients with Hypoxia-Induced Pulmonary Hypertension.

Acta Cardiol Sin 2018 Nov;34(6):511-517

Division of Cardiology, Department of Internal Medicine, Chi-Mei Medical Center.

Background: The outcome of pulmonary hypertension (PH) mainly depends on the development of right ventricular (RV) dysfunction, and survival among patients with different etiologies of PH varies. Chronic hypoxia is a major cause of secondary PH, however the mechanisms of its associated RV dysfunction are largely unknown. Herein, we studied the role of microRNA-21 (miR-21) in hypoxia-induced RV dysfunction. Read More

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http://www.tsoc.org.tw/upload/journal/1/20181109/acs-34-511.
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http://dx.doi.org/10.6515/ACS.201811_34(6).20180613ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236563PMC
November 2018
9 Reads

Prevalence and Outcomes of Isolated Tricuspid Valve Surgery Among Medicare Beneficiaries.

Am J Cardiol 2019 Jan 27;123(1):132-138. Epub 2018 Sep 27.

Smith Clinical Outcomes Center and the Departments of Internal Medicine (Cardiovascular Division), Cardiac Surgery at the Beth Israel Deaconess Medical Center, Boston, Massachusetts.

We sought to characterize the clinical outcomes and to identify predictors of mortality undergoing isolated tricuspid valve surgery in the United States. We identified 5,164 patients undergoing isolated tricuspid valve surgery from the Centers for Medicare and Medicaid Services Medicare Provider Analysis and Review data between January 2003 and December 2014. The primary outcome was all cause 1-year mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183183
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http://dx.doi.org/10.1016/j.amjcard.2018.09.016DOI Listing
January 2019
8 Reads
3.276 Impact Factor

Main title: pulmonary vascular disease is evident in gene regulation of experimental bronchopulmonary dysplasia.

J Matern Fetal Neonatal Med 2018 Nov 14:1-241. Epub 2018 Nov 14.

a Department of Pediatric Research , University of Oslo , Oslo , Norway.

Objective: To examine the gene expression regarding pulmonary vascular disease in experimental bronchopulmonary dysplasia in young mice. Premature delivery puts babies at risk of severe complications. Bronchopulmonary dysplasia (BPD) is a common complication of premature birth leading to lifelong affection of pulmonary function. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1541081DOI Listing
November 2018
6 Reads

Prenatal treatment with rosiglitazone attenuates vascular remodeling and pulmonary monocyte influx in experimental congenital diaphragmatic hernia.

PLoS One 2018 12;13(11):e0206975. Epub 2018 Nov 12.

National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland.

Introduction: Extensive vascular remodeling causing pulmonary hypertension (PH) represents a major cause of mortality in patients with congenital diaphragmatic hernia (CDH). The chemokine monocyte chemoattractant protein-1 (MCP-1) is a biomarker for the severity of PH and its activation is accompanied by pulmonary influx of monocytes and extensive vascular remodeling. MCP-1 activation can be reversed by application of rosiglitazone (thiazolidinedione). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206975PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231640PMC
November 2018
8 Reads

An unusual case of hypercapnic respiratory failure.

Respir Med Case Rep 2018 23;25:327-329. Epub 2018 Oct 23.

University of Florida College of Medicine, Pulmonary & Critical Care, USA.

Asphyxiating thoracic dystrophy (ATD also known as Jeune syndrome) is a very rare disorder with an incidence in the United States of 1 case per 100,000-130,000 live births. Chronic alveolar hypoventilation leading to concurrent hypoxia is the main cause of morbidity and mortality in these patients due to its complications. A 22-year-old male with past medical history of ATD and severe kyphoscoliosis presented with progressively worsening shortness of breath for several days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183020
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http://dx.doi.org/10.1016/j.rmcr.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214860PMC
October 2018
10 Reads

The incidence of symptomatic in-hospital VTEs in Asian patients undergoing joint arthroplasty was low: a prospective, multicenter, 17,660-patient-enrolled cohort study.

Knee Surg Sports Traumatol Arthrosc 2018 Nov 1. Epub 2018 Nov 1.

Department of Orthopaedic Surgery, West China Medical School, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Purpose: The aim of this study was to determine the real incidence of symptomatic in-hospital venous thromboembolism (VTE) and identify risk factors for VTEs in Asian patients undergoing total hip (THA) and total knee arthroplasty (TKA).

Methods: A total of 17,660 patients (20,078 hips and knees) undergoing THA and TKA at 78 hospitals were enrolled. The composite incidence of symptomatic in-hospital DVT and PE was identified as the primary effectiveness outcomes. Read More

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http://link.springer.com/10.1007/s00167-018-5253-3
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http://dx.doi.org/10.1007/s00167-018-5253-3DOI Listing
November 2018
3 Reads

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD).

Cochrane Database Syst Rev 2018 10 30;10:CD009764. Epub 2018 Oct 30.

Department of Respiratory and Sleep Medicine, Westmead Public Hospital, Sydney, New South Wales, Australia.

Background: There has been renewal of interest in the use of prophylactic antibiotics to reduce the frequency of exacerbations and improve quality of life in chronic obstructive pulmonary disease (COPD).

Objectives: To determine whether or not regular (continuous, intermittent or pulsed) treatment of COPD patients with prophylactic antibiotics reduces exacerbations or affects quality of life.

Search Methods: We searched the Cochrane Airways Group Trials Register and bibliographies of relevant studies. Read More

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http://dx.doi.org/10.1002/14651858.CD009764.pub3DOI Listing
October 2018
8 Reads

Mild Pulmonary Hypertension Is Associated With Increased Mortality: A Systematic Review and Meta-Analysis.

J Am Heart Assoc 2018 Sep;7(18):e009729

1 Providence Veterans Affairs Medical Center Warren Alpert Medical School of Brown University Providence RI.

Background Recent studies have demonstrated a continuum in clinical risk related to mean pulmonary artery pressure that begins at >19 mm Hg, which is below the traditional threshold used to define pulmonary hypertension ( PH ) of 25 mm Hg. Because of the implications on patient diagnosis and prognosis, the generalizability and validity of these data need further confirmation. Methods and Results Databases were searched from inception through January 31, 2018, to identify studies comparing all-cause mortality between patients with mildly elevated mean pulmonary artery pressure near but <25 mm Hg versus the referent group. Read More

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http://dx.doi.org/10.1161/JAHA.118.009729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222957PMC
September 2018
3 Reads

Tako-Tsubo Cardiomyopathy in Severe Sepsis: Nationwide Trends, Predictors, and Outcomes.

J Am Heart Assoc 2018 Sep;7(18):e009160

2 Division of Pulmonary and Critical Care Medicine Department of Medicine Mayo Clinic Rochester MN.

Background There are limited data on the presentation of Takotsubo cardiomyopathy ( TTC ) in severe sepsis. Methods and Results This was a retrospective cohort study using the National Inpatient Sample database (2007-2013) of all adults with severe sepsis. TTC was identified in patients with severe sepsis using previously validated administrative codes. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009160
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http://dx.doi.org/10.1161/JAHA.118.009160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222948PMC
September 2018
9 Reads
2.882 Impact Factor

First Reported Case of Pulmonary Arterial Hypertension Secondary to Tofacitinib Treatment for Undifferentiated Arthritis.

J Clin Rheumatol 2018 Oct 23. Epub 2018 Oct 23.

Sydney Adventist Hospital and North Shore Private Hospital Sydney, New South Wales Australia Faculty of Medicine and Health Sciences Macquarie University Sydney, New South Wales Australia University of Sydney Sydney, New South Wales Australia Sydney Medical School and Sydney University Clinical School Sydney, New South Wales Australia Macquarie University Sydney, New South Wales Australia Macquarie University Hospital Sydney, New South Wales Australia.

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http://dx.doi.org/10.1097/RHU.0000000000000889DOI Listing
October 2018

Leukemoid Reaction in Infant Pertussis: Is There a Place for Hydroxyurea? A Case Report.

Front Pediatr 2018 26;6:261. Epub 2018 Sep 26.

Pediatric Intensive Care Unit, Lausanne University Hospital, Lausanne, Switzerland.

A 73-days old infant of 34 weeks' gestation was hospitalized with a co-infection of respiratory syncytial virus (RSV) and . She required invasive ventilation for 9 days in the context of malignant pertussis with persistent hypoxemia and hypercapnia secondary to a leukemoid reaction. Despite an increase of white blood cell (WBC) count up to 70 G/L and ensuing pulmonary hypertension, no hemodynamic compromise occurred. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00261/
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http://dx.doi.org/10.3389/fped.2018.00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190881PMC
September 2018
11 Reads