3,902 results match your criteria Pulmonary Hypertension Secondary


Sex-Specific Determinants of Outcomes After Transcatheter Aortic Valve Replacement.

Circ Cardiovasc Qual Outcomes 2019 Mar;12(3):e005363

Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Montreal, QC, Canada (A.T., J.A.).

Background Women account for a large proportion of patients treated with transcatheter aortic valve replacement, yet there remain conflicting reports about the effect of sex on outcomes. Moreover, the sex-specific prevalence and prognostic impact of frailty has not been systematically studied in the context of transcatheter aortic valve replacement. Methods and Results A preplanned analysis of the FRAILTY-AVR study (Frailty Aortic Valve Replacement) was performed to analyze the determinants of outcomes in older women and men undergoing transcatheter aortic valve replacement. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005363DOI Listing

Comparison of secondary prevention in coronary heart disease patients living in rural and urban areas.

Turk Kardiyol Dern Ars 2019 Mar;47(2):128-136

Department of Cardiology, Ege University Faculty of Medicine, İzmir.

Objective: The aim of the present study was to assess differences between urban and rural patients with coronary heart disease (CHD) with respect to secondary prevention.

Methods: This cross-sectional study included all consecutive patients diagnosed with CHD at 2 cardiology clinics between January 2016 and January 2017. The demographic characteristics and laboratory parameters were recorded at routine control visits. Read More

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http://dx.doi.org/10.5543/tkda.2018.68782DOI Listing

Outcome of pregnancies in women with Pulmonary Hypertension: A Single Centre Experience from South India.

BJOG 2019 Mar 14. Epub 2019 Mar 14.

Anaesthesiology& Critical Care, Jawaharlal Institute of Post-graduate Medical Education & Research (JIPMER), Puducherry, India, 605006.

Objective: To study maternal complications and pregnancy outcome in women with pulmonary hypertension, attending a tertiary centre in south India.

Study Design: Retrospective Observational study.

Setting: Tertiary centre in south India. Read More

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http://dx.doi.org/10.1111/1471-0528.15681DOI Listing
March 2019
1 Read

Thrombus risk versus bleeding risk: a clinical conundrum.

BMJ Case Rep 2019 Mar 8;12(3). Epub 2019 Mar 8.

School of Medicine, University of Notre Dame, Fremantle, Western Australia, Australia.

A 62-year-old man presented to the Emergency Department with dyspnoea and central pleuritic chest pain radiating posteriorly to between the scapulae. His medical history included hypertension, osteoporosis and chronic kidney disease secondary to focal segmental glomerulosclerosis with relapsing nephrotic syndrome. Significant examination findings included a loud palpable P2 and a displaced apex beat. Read More

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http://dx.doi.org/10.1136/bcr-2018-228344DOI Listing
March 2019
1 Read

Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review.

Stem Cell Res Ther 2019 Mar 6;10(1):75. Epub 2019 Mar 6.

Regenerative Medicine Program, The Ottawa Hospital Research Institute, 501 Smyth Road, PO Box 201B, Ottawa, ON, K1H 8L6, Canada.

Background: Pulmonary arterial hypertension (PAH) is a rare disease characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary arterial pressures leading to pathological right ventricular remodeling and ultimately right heart failure. Regenerative cell therapies could potentially restore the effective lung microcirculation and provide a curative therapy for PAH. The objective of this systematic review was to compare the efficacy of regenerative cell therapies in preclinical models of PAH. Read More

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http://dx.doi.org/10.1186/s13287-019-1172-6DOI Listing
March 2019
1 Read

Exploring clinical, echocardiographic and molecular biomarkers to predict bronchopulmonary dysplasia.

PLoS One 2019 6;14(3):e0213210. Epub 2019 Mar 6.

Pediatric Cardiology Department, Ramón y Cajal University Hospital, Madrid, Spain.

Introduction: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in childhood, related to prematurity, and the most common cause of pulmonary hypertension (PH) secondary to pulmonary disease in children. Moderate and severe BPD have a worse outcome and relate more frequently with PH. The prediction of moderate or severe BPD development in extremely premature newborns is vital to implement preventive strategies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213210PLOS
March 2019
2 Reads

Human amnion cells for the prevention of bronchopulmonary dysplasia: a protocol for a phase I dose escalation study.

BMJ Open 2019 Mar 1;9(2):e026265. Epub 2019 Mar 1.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

Introduction: Bronchopulmonary dysplasia (BPD), an important sequela of preterm birth, is associated with long-term abnormalities of lung function and adverse neurodevelopmental outcomes. Inflammation, inhibition of secondary septation and vascular maldevelopment play key roles in the pathogenesis of BPD. Human amnion epithelial cells (hAECs), stem-like cells, derived from placental tissues are able to modulate the inflammatory milieu and, in preclinical studies of BPD-like injury, restore lung architecture and function. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026265DOI Listing
March 2019
2 Reads

Transport on extracorporeal membrane oxygenation for congenital diaphragmatic hernia: A unique center experience.

J Pediatr Surg 2019 Feb 8. Epub 2019 Feb 8.

ECMO Center Karolinska, Department of Pediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Background: Support on Extracorporeal oxygenation membrane (ECMO) represents the last therapeutic option in the management of respiratory failure and pulmonary hypertension refractory to treatment in patients with congenital diaphragmatic hernia (CDH).

Aim: The objective of this work was to present our experience of all the cases of CDH that we have transported on ECMO.

Material And Methods: Medical records of patients, national and international, with CDH transported by our service on ECMO from 1997 to 2018 were reviewed. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.11.022DOI Listing
February 2019
1 Read

Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies.

Am J Physiol Heart Circ Physiol 2019 Mar 1. Epub 2019 Mar 1.

National Jewish Health, United States.

Despite different developmental and pathologic processes affecting lung vascular remodeling in both patient populations, differences in 4D-MRI findings between children and adults with PAH have not been studied. The purpose of this study was to compare flow hemodynamic state, including flow-mediated shear forces, between pediatric and adult patients with PAH matched by severity of pulmonary vascular resistance index (PVRi). Adults (n=10) and children (n=10) with PAH matched by pulmonary vascular resistance index (PVRi), and healthy adult (n=10) and pediatric (n=10) subjects underwent comprehensive 4D-Flow MRI to assess peak systolic wall shear stress (WSS) measured in the main, right, and left pulmonary arteries (MPA, RPA, and LPA), viscous energy loss ( E) along the MPA-RPA and MPA-LPA tract, and qualitative analysis of secondary flow hemodynamics. Read More

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http://dx.doi.org/10.1152/ajpheart.00802.2018DOI Listing
March 2019
2 Reads

Serum copeptin: a potential guide to clinical decision-making for congenital shunt closure.

Heart 2019 Mar;105(6):499-500

Cardiology Department, Trakya Universitesi, Edirne, Turkey.

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http://dx.doi.org/10.1136/heartjnl-2018-314598DOI Listing

Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension.

Int J Chron Obstruct Pulmon Dis 2019 11;14:381-389. Epub 2019 Feb 11.

Université de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, F-33000 Bordeaux, France,

Background: Little is known about in vivo alterations at bronchial and vascular levels in severe pulmonary hypertension (PH) of different etiologies. We aimed to compare quantitative computed tomography (CT) data from the following three groups of severe precapillary PH patients: COPD, idiopathic pulmonary arterial hypertension (iPAH), and chronic thromboembolic PH (CTEPH).

Patients And Methods: This study was approved by the institutional review board. Read More

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http://dx.doi.org/10.2147/COPD.S177638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377046PMC
February 2019
1 Read

Unilateral absence of the pulmonary veins: an unusual diagnosis with characteristic imaging findings.

Clin Imaging 2019 Jan 30;55:107-111. Epub 2019 Jan 30.

Department of Radiology, Helen DeVos Children's Hospital and Spectrum Health, Advanced Radiology Services, Grand Rapids, MI, United States of America; New York Medical College, Valhalla, NY, United States of America.

Background: Congenital unilateral absence of the pulmonary vein (UCAPV) is a rare entity with characteristic clinical and imaging findings. Despite its congenital nature, the radiographic findings and symptoms of UCAPV may not be recognized at birth and patients may present in childhood or early adulthood with findings that may mimic other diagnoses.

Methods: The evolution of imaging findings in UCAPV is presented through two cases, one of which demonstrates the progression of findings over several years. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.022DOI Listing
January 2019
3 Reads

A unique case of ectopic Cushing's syndrome from a thymic neuroendocrine carcinoma.

Endocrinol Diabetes Metab Case Rep 2019 Feb 22;2019. Epub 2019 Feb 22.

Departments of Endocrinology, Diabetes & Metabolism, Cleveland Clinic, Cleveland, Ohio, USA.

Ectopic adrenocorticotropic hormone (ACTH) production leading to ectopic ACTH syndrome accounts for a small proportion of all Cushing's syndrome (CS) cases. Thymic neuroendocrine tumors are rare neoplasms that may secrete ACTH leading to rapid development of hypercortisolism causing electrolyte and metabolic abnormalities, uncontrolled hypertension and an increased risk for opportunistic infections. We present a unique case of a patient who presented with a mediastinal mass, revealed to be an ACTH-secreting thymic neuroendocrine tumor (NET) causing ectopic CS. Read More

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http://dx.doi.org/10.1530/EDM-19-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391898PMC
February 2019

Descending Aortic Translocation and Right Pulmonary Artery Reimplantation for Midline Descending Aorta and Crossed Pulmonary Arteries in an Infant.

World J Pediatr Congenit Heart Surg 2019 01;10(1):111-115

1 Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Left mainstem bronchial compression by a midline descending thoracic aorta is a rare anatomic variant. Translocation of the descending thoracic aorta to the ascending aorta has recently been described to treat this condition. We performed an aortic translocation and right pulmonary artery reimplantation in a 4-month-old infant with severe pulmonary hypertension secondary to right pulmonary artery stenosis and left bronchial compression by a midline descending thoracic aorta. Read More

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http://dx.doi.org/10.1177/2150135118815027DOI Listing
January 2019
1 Read

[Analysis of risk factors of pulmonary infection in patients over 60 years of age after radical resection for gastric cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Feb;22(2):164-171

Department IV of Gastrointestinal Cancer Center, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142,China, Email:

Objective: To investigate the risk factors of postoperative pulmonary infection (PPI) in patients over 60 years of age with gastric cancer after radical gastrectomy.

Methods: Clinicopathological data of 373 patients over 60 years of age who underwent radical gastrectomy at Department IV of Gastrointestinal Cancer Center, Peking University Cancer Hospital, from April 2009 to December 2016 were retrospectively collected in this case-control study. The clinicopathological characteristics of patients with postoperative pulmonary infection (including postoperative atelectasis) and those without pulmonary infection were compared. Read More

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February 2019
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Pulmonary hypertension secondary to congenital diaphragmatic hernia: factors and pathways involved in pulmonary vascular remodeling.

Pediatr Res 2019 Feb 19. Epub 2019 Feb 19.

Division of General and Thoracic Surgery, Department of Surgery, The Hospital for Sick Children, Toronto, Canada.

Congenital diaphragmatic hernia (CDH) is a severe birth defect that is characterized by pulmonary hypoplasia and pulmonary hypertension (PHTN). PHTN secondary to CDH is a result of vascular remodeling, a structural alteration in the pulmonary vessel wall that occurs in the fetus. Factors involved in vascular remodeling have been reported in several studies, but their interactions remain unclear. Read More

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http://www.nature.com/articles/s41390-019-0345-4
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http://dx.doi.org/10.1038/s41390-019-0345-4DOI Listing
February 2019
5 Reads

Forty-year-old man with dyspnoea, haemoptysis and night sweats.

Heart 2019 Feb 16. Epub 2019 Feb 16.

Department of Cardiology, Royal Victoria Hospital, Belfast, UK.

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http://dx.doi.org/10.1136/heartjnl-2018-314511DOI Listing
February 2019
2 Reads

Pulmonary Vascular Mechanical Consequences of Ischemic Heart Failure and Implications for Right Ventricular Function.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

University of Wisconsin-Madison.

Motivation: Left heart failure (LHF) is the most common cause of pulmonary hypertension, which confers an increase in morbidity and mortality in this context. Pulmonary vascular resistance has prognostic value in LHF but otherwise the mechanical consequences of LHF for the pulmonary vasculature and right ventricle remain unknown. We sought to investigate mechanical mechanisms of pulmonary vascular and right ventricular dysfunction in a rodent model of LHF to address the knowledge gaps in understanding disease pathophysiology. Read More

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http://dx.doi.org/10.1152/ajpheart.00319.2018DOI Listing
February 2019
2 Reads
3.838 Impact Factor

Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.

Br J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Dorset County Hospital NHS Foundation Trust, Williams Avenue, Dorchester, Dorset, DT1 2JY.

Background And Purpose: Pulmonary arterial hypertension (PAH) is an incurable, incapacitating disorder resulting from increased pulmonary vascular resistance, pulmonary arterial remodeling and right ventricular failure. In pre-clinical models, combination of a phosphodiesterase 5 inhibitor (PDE5i) with a neprilysin inhibitor augments natriuretic peptide bioactivity, promotes cyclic GMP signaling, and reverses the structural and hemodynamic deficits that characterize PAH. Herein, we conducted a randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of repurposing the neprilysin inhibitor, racecadotril, in PAH. Read More

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http://dx.doi.org/10.1111/bph.14621DOI Listing
February 2019
1 Read

Traumatic Pulmonary Hypertension Secondary to Arteriovenous Fistula and Remote Gunshot Wound.

Can J Cardiol 2019 Feb 8;35(2):229.e11-229.e13. Epub 2018 Dec 8.

Division of Respiratory and Sleep Medicine, Departments of Medicine and Critical Care Medicine, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada.

Pulmonary hypertension is a known complication of high-flow arteriovenous fistulas (AVFs). We present a case of a 58-year-old man who sustained a gunshot wound 6.5 years before presentation for worsening pulmonary hypertension (PH). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.003DOI Listing
February 2019
2 Reads

Efficacy of stem cell therapy for pulmonary arterial hypertension: a systematic review and meta-analysis of preclinical studies.

Stem Cell Res Ther 2019 Feb 13;10(1):55. Epub 2019 Feb 13.

General ICU, Henan Key Laboratory of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Background: Despite significant progress in drug treatment, the prognosis of patients with advanced pulmonary arterial hypertension (PAH) remains extremely poor. Many preclinical studies have reported the efficacy of stem cell (SC) therapy for PAH; however, this approach remains controversial. The aim of this systematic review and meta-analysis is to assess the potential efficacy of SC therapy for PAH. Read More

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http://dx.doi.org/10.1186/s13287-019-1162-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374914PMC
February 2019
1 Read

Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD).

Can J Anaesth 2019 Feb 12. Epub 2019 Feb 12.

Klinik für Anästhesiologie, LMU Klinikum der Universität München, Munich, Germany.

Purpose: Perioperative right ventricular (RV) failure due to pressure overload from pulmonary hypertension (PH) worsens postoperative outcomes after cardiac surgery. Inhaled iloprost is a potent pulmonary vasodilator improving RV performance, ameliorating myocardial and pulmonary ischemia-reperfusion injury and attenuating inflammation. We hypothesized that the prophylactic inhalation of iloprost would reduce postoperative ventilation times after cardiac surgery. Read More

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http://dx.doi.org/10.1007/s12630-019-01309-8DOI Listing
February 2019
1 Read

Improving medical care and prevention in adults with congenital heart disease-reflections on a global problem-part II: infective endocarditis, pulmonary hypertension, pulmonary arterial hypertension and aortopathy.

Cardiovasc Diagn Ther 2018 Dec;8(6):716-724

Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technical University Munich, Munich, Germany.

Despite relevant residua and sequels, follow-up care of adults with congenital heart disease (ACHD) is too often not performed by/in specialized and/or certified physicians or centers although major problems in the long-term course may develop. The most relevant encompass heart failure, cardiac arrhythmias, heart valve disorders, pulmonary vascular disease, infective endocarditis (IE), aortopathy and non-cardiac comorbidities. The present publication emphasizes current data on IE, pulmonary and pulmonary arterial hypertension and aortopathy in ACHD and underlines the deep need of an experienced follow-up care by specialized and/or certified physicians or centers, as treatment regimens from acquired heart disease can not be necessarily transmitted to CHD. Read More

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http://dx.doi.org/10.21037/cdt.2018.10.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331381PMC
December 2018
2 Reads

Pulmonary Hypertension Secondary to Scurvy in a Developmentally Typical Child.

J Pediatr 2019 Feb 6. Epub 2019 Feb 6.

Section of Cardiology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476193002
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http://dx.doi.org/10.1016/j.jpeds.2018.12.068DOI Listing
February 2019
4 Reads

Pulmonary Artery Denervation Significantly Increases 6-Min Walk Distance for Patients With Combined Pre- and Post-Capillary Pulmonary Hypertension Associated With Left Heart Failure: The PADN-5 Study.

JACC Cardiovasc Interv 2019 Feb 23;12(3):274-284. Epub 2018 Oct 23.

Division of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address:

Objectives: The authors sought to assess the benefits of pulmonary artery denervation (PADN) among combined pre- and post-capillary pulmonary hypertension (CpcPH) patients in a prospective, randomized, sham-controlled trial.

Background: PADN has been shown to improve hemodynamics of pulmonary arterial hypertension in a series of patients. Additionally, benefits of targeted medical therapy for patients with CpcPH secondary to left-sided heart failure are unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19368798183193
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http://dx.doi.org/10.1016/j.jcin.2018.09.021DOI Listing
February 2019
9 Reads

Current Use and Impact on 30-Day Mortality of Pulmonary Artery Catheter in Cardiogenic Shock Patients: Results From the CardShock Study.

J Intensive Care Med 2019 Feb 7:885066619828959. Epub 2019 Feb 7.

12 Critical Care Department, Hospital Sant Joan Despi Moisès Broggi, Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain.

Background:: Cardiogenic shock (CS) is the most life-threatening manifestation of acute heart failure. Its complexity and high in-hospital mortality may justify the need for invasive monitoring with a pulmonary artery catheter (PAC).

Methods:: Patients with CS included in the CardShock Study, an observational, prospective, multicenter, European registry, were analyzed, aiming to describe the real-world use of PAC, evaluate its impact on 30-day mortality, and the ability of different hemodynamic parameters to predict outcomes. Read More

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http://dx.doi.org/10.1177/0885066619828959DOI Listing
February 2019
2 Reads

Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Mar 1;20(3):420-435. Epub 2019 Feb 1.

Weill Cornell Medical College, NY, USA; New York Presbyterian Hospital, New York, NY, USA.

Background: VEGF and VEGF receptor 2 (VEGFR-2)-mediated signalling and angiogenesis can contribute to the pathogenesis and progression of gastric cancer. We aimed to assess whether the addition of ramucirumab, a VEGFR-2 antagonist monoclonal antibody, to first-line chemotherapy improves outcomes in patients with metastatic gastric or gastro-oesophageal junction adenocarcinoma.

Methods: For this double-blind, randomised, placebo-controlled, phase 3 trial done at 126 centres in 20 countries, we recruited patients aged 18 years or older with metastatic, HER2-negative gastric or gastro-oesophageal junction adenocarcinoma, an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, and adequate organ function. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30791-5DOI Listing
March 2019
21 Reads
24.690 Impact Factor

A successful case of external stenting for bronchomalacia lasting over 20 years.

Ann Thorac Surg 2019 Feb 1. Epub 2019 Feb 1.

Department of Cardiovascular Surgery.

The patient had a perimembranous ventricular septal defect and pulmonary hypertension. He underwent pulmonary artery banding followed by external stenting of the left bronchus because of secondary bronchomalacia. The external stent applied was a ringed expanded polytetrafluoroethylene graft, 10 mm in diameter and fixed at 8 points. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.055DOI Listing
February 2019

Transesophageal Echocardiography in Heart and Lung Transplantation.

J Cardiothorac Vasc Anesth 2019 Jan 7. Epub 2019 Jan 7.

Department of Anaesthetics and Intensive Care, Royal Papworth Hospital, Cambridge, UK.

The number of heart and lung transplantations has risen over the years, and they remain the mainstay of treatment for end-stage heart failure and end-stage lung diseases. From the assessment of the donor's heart to intraoperative management during separation from cardiopulmonary bypass (CPB) to the postoperative follow-up of heart transplant patients, echocardiography plays a vital role throughout this process. Patients with chronic lung diseases also may have cardiovascular compromise secondary to pulmonary hypertension, pre-existing coronary artery disease, or valvular heart disease. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.005DOI Listing
January 2019
2 Reads

Hospitalizations with hereditary hemorrhagic telangiectasia and pulmonary hypertension in the United States from 2000 to 2014.

Respir Med 2019 Feb 2;147:26-30. Epub 2019 Jan 2.

Actelion Clinical Research, Allschwil, Switzerland. Electronic address:

Background: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease that causes widespread abnormal vasculature development, resulting in multiple complications including pulmonary hypertension (PH). Despite the potential severity of PH, there is a lack of data on hospitalization characteristics and outcomes in the HHT-PH population. The purpose of this analysis was to describe trends and outcomes of HHT-PH hospitalizations within the National (Nationwide) Inpatient Sample (NIS). Read More

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http://dx.doi.org/10.1016/j.rmed.2018.12.013DOI Listing
February 2019

Clinical observation pseudoobstruction syndrome of the stomach's output part and small intestine of a patient with systematic lupus erythematosis.

Ter Arkh 2018 Feb;90(2):98-101

N.I. Pirogov City Clinical Hospital №1, Moscow Healthcare Department, Moscow, Russia.

Stomach's output part and small intestine, combining with damaging of the urinary tract is a rare systemic lupus eritematosus (SLE) manifestation. The patient is 32 years old, suffering from SLE with damaged join, blood system, secondary antiphospholipid syndrome with pulmonary embolism in the history and formation of high postembolic pulmonary hypertension on therapy with hydroxychloroquine and low doses of corticosteroids, was hospitalized because of persistent nausea, vomiting, loss of more than 10 kg body weight 1.5 months. Read More

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http://dx.doi.org/10.26442/terarkh201890298-101DOI Listing
February 2018
1 Read

Phosphodiesterase 5 inhibitors for pulmonary hypertension.

Cochrane Database Syst Rev 2019 Jan 31;1:CD012621. Epub 2019 Jan 31.

Department of Respiratory Medicine, The Alfred Hospital, Commercial Rd, Melbourne, Australia, 3004.

Background: Pulmonary hypertension (PH) comprises a group of complex and heterogenous conditions, characterised by elevated pulmonary artery pressure, and which left untreated leads to right-heart failure and death. PH includes World Health Organisation (WHO) Group 1 pulmonary arterial hypertension (PAH); Group 2 consists of PH due to left-heart disease (PH-LHD); Group 3 comprises PH as a result of lung diseases or hypoxia, or both; Group 4 includes PH due to chronic thromboembolic occlusion of pulmonary vasculature (CTEPH), and Group 5 consists of cases of PH due to unclear and/or multifactorial mechanisms including haematological, systemic, or metabolic disorders. Phosphodiesterase type 5 (PDE5) inhibitors increase vasodilation and inhibit proliferation. Read More

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http://dx.doi.org/10.1002/14651858.CD012621.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354064PMC
January 2019
1 Read

Spontaneous Septostomy in a Twin Pregnancy Causing Fatal Amniotic Band Syndrome.

Case Rep Pediatr 2018 30;2018:4549060. Epub 2018 Dec 30.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Complications due to spontaneous septostomy of the dividing membrane in monochorionic diamniotic pregnancies are rarely described. Herein, we report the case of a preterm female neonate from a monochorionic diamniotic twin pregnancy delivered by caesarean section at 32 weeks of gestation. She was born with a broad band of a transparent membrane-like material firmly attached to her lower abdomen. Read More

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http://dx.doi.org/10.1155/2018/4549060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332983PMC
December 2018
1 Read

Obstructive sleep apnoea and comorbidity - an overview of the association and impact of continuous positive airway pressure therapy.

Expert Rev Respir Med 2019 Mar 11;13(3):251-261. Epub 2019 Feb 11.

a Department of Respiratory and Sleep Medicine, St. Vincent's Hospital Group and School of Medicine , University College Dublin , Dublin , Ireland.

Introduction: Obstructive sleep apnoea (OSA) is highly prevalent and there is considerable evidence supporting an independent association with a wide range of co-morbidities including cardiovascular, endocrine and metabolic, neuropsychiatric, pulmonary, and renal. Areas covered: A PubMed search of all the recent literature relating to OSA and co-morbidities was undertaken to critically evaluate the potential relationships and possible benefit of continuous positive airway pressure (CPAP) therapy. Expert commentary: The evidence supporting an independent association is stronger for some co-morbidities than others and in cardiovascular diseases is strongest for hypertension and atrial fibrillation. Read More

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http://dx.doi.org/10.1080/17476348.2019.1575204DOI Listing
March 2019
2 Reads

Sildenafil for Pulmonary Hypertension in the Early Postoperative Period After Mitral Valve Surgery.

J Cardiothorac Vasc Anesth 2018 Dec 25. Epub 2018 Dec 25.

Department of Cardiac Surgery, Sheba Medical Center at Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: The phosphodiesterase-5 inhibitor sildenafil was developed for the treatment of pulmonary hypertension. The authors investigated the efficacy and safety of sildenafil in the early postoperative period after mitral valve surgery in patients with pulmonary hypertension.

Design: A double-blind, placebo-controlled randomized trial was performed. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.12.023DOI Listing
December 2018
3 Reads

Pulmonary hypertension on systemic sclerosis-lupus erythematosus overlap syndrome.

Ann Cardiol Angeiol (Paris) 2019 Jan 23. Epub 2019 Jan 23.

Habib Thameur Hospital, Internal Medicine Department, Tunis, Tunisia; University of Tunis el Manar Faculty of Medicine of Tunis, Tunisia.

Purpose: There are authentic observations of combination of systemic lupus erythematosus (SLE) with systemic sclerosis (SS) and with polymyositis defined as overlap syndromes. The prevalence of pulmonary hypertension is unknown in SS-SLE overlap syndrome because of its rarity. The aim of our study was to precise clinical, paraclinical and evolutive features of pulmonary hypertension in patients with systemic sclerosis-systemic lupus erythematosus (SS-SLE) overlap syndrome. Read More

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http://dx.doi.org/10.1016/j.ancard.2018.10.012DOI Listing
January 2019
2 Reads

Rapid development of pulmonary hypertension during treatment of paediatric cancer.

Cardiol Young 2019 Jan 25:1-4. Epub 2019 Jan 25.

Department of Pediatrics,Washington University School of Medicine,Children's Place,St Louis, MO,USA.

Paediatric pulmonary hypertension has been described as a secondary complication of multiple diseases and their treatment. Limited information exists about the relationship between pulmonary hypertension and cancer in children. A review of charts was performed in all patients treated for cancer and developed pulmonary hypertension. Read More

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http://dx.doi.org/10.1017/S1047951118002196DOI Listing
January 2019
2 Reads

A case report of the successful administration of clozapine in the face of myocardial infarction, pulmonary embolism and hyperlipidaemia resulting in the termination of long-term seclusion.

Authors:
Alex Till Ed Silva

BMC Psychiatry 2019 Jan 23;19(1):37. Epub 2019 Jan 23.

Ashworth Hospital, Mersey Care NHS Trust, Parkbourn, Maghull, Liverpool, Merseyside, L31 1HW, UK.

Background: Cardiometabolic health significantly impacts on the mortality of people with severe mental illness. Clozapine has the greatest efficacy for Treatment Resistant Schizophrenia (TRS) but the greatest negative impact on cardiometabolic health. Balancing the risks and benefits of treatment, dignity, autonomy, liberty, mental and physical health can be challenging, particularly when imposing interventions with potentially life threatening adverse events, such as clozapine. Read More

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http://dx.doi.org/10.1186/s12888-018-2001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343332PMC
January 2019
3 Reads

Treatment of Hypertensive Cardiogenic Edema with Intravenous High-Dose Nitroglycerin in a Patient Presenting with Signs of Respiratory Failure: A Case Report and Review of the Literature.

Am J Case Rep 2019 Jan 21;20:83-90. Epub 2019 Jan 21.

Department of Internal Medicine, San Juan City Hospital, San Juan, Puerto Rico.

BACKGROUND Pulmonary edema is the accumulation of fluid in the lung secondary to increased hydrostatic pressure. Hypertensive cardiogenic pulmonary edema presents with a sudden onset of severe dyspnea, tachycardia, and tachypnea, and can occur when the systolic blood pressure exceeds 160 mmHg in association with acute decompensated congestive cardiac failure (CCF). A case is presented of hypertensive cardiogenic pulmonary edema treated with high-dose nitroglycerin and includes a review of the literature. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913250
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http://dx.doi.org/10.12659/AJCR.913250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350673PMC
January 2019
12 Reads

Differences in clinical characteristics and 1-year outcomes of hospitalized patients with heart failure in ESC-HF Pilot and ESC-HF-LT registries.

Pol Arch Intern Med 2019 02 16;129(2):106-116. Epub 2019 Jan 16.

INTRODUCTION The management of heart failure (HF) has changed significantly in recent decades. OBJECTIVES We analyzed the clinical profile, 1‑year outcomes, predictors of mortality, and hospital readmissions in hospitalized patients enrolled in the European Society of Cardiology Heart Failure Pilot Survey (ESC‑HF Pilot) and Heart Failure Long‑Term Registry (ESC‑HF‑LT). PATIENTS AND METHODS The analysis included hospitalized Polish patients from both registries. Read More

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http://pamw.pl/en/node/4418
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http://dx.doi.org/10.20452/pamw.4418DOI Listing
February 2019
12 Reads

Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors.

Pulm Circ 2019 Jan-Mar;9(1):2045894019825763

1 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Pulmonary hypertension (PH) occurs when the pulmonary vasculature is itself diseased or becomes affected secondarily by comorbid conditions, commonly left heart or lung disease. The high prevalence of chronic cardiopulmonary conditions among patients served by Veterans Health Administration (VHA) suggests this population may be particularly susceptible to PH. We sought to identify clinical features and outcomes in veterans diagnosed with PH. Read More

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http://dx.doi.org/10.1177/2045894019825763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381440PMC
January 2019
1 Read

Impact of preoperative pulmonary arterial hypertension on early and late outcomes in patients undergoing valve surgery for rheumatic heart disease.

Indian J Anaesth 2018 Dec;62(12):963-971

Department of Cardiac Anesthesia, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India.

Background And Aims: There is conflicting evidence on adverse effect of Pulmonary Arterial Hypertension (PAH) on outcomes after cardiac surgery for rheumatic heart disease (RHD). The authors studied Indian patients with RHD and preoperative PAH, who undergo cardiac surgery with a hypothesis that they have poor short and long-term outcomes.

Methods: This was a retrospective observational study of 407 patients. Read More

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http://dx.doi.org/10.4103/ija.IJA_374_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299764PMC
December 2018
1 Read

Effect of pulmonary artery denervation in postcapillary pulmonary hypertension: results of a randomized controlled translational study.

Basic Res Cardiol 2019 01 11;114(2). Epub 2019 Jan 11.

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

There is scarce evidence for pulmonary artery denervation (PADN) as a potential treatment for chronic postcapillary pulmonary hypertension (PH). We aimed to perform a proof-of-concept of PADN in a translational model of chronic PH. Nineteen pigs with chronic postcapillary PH (secondary to pulmonary vein banding) were randomized to surgical-PADN (using bipolar radiofrequency clamps) or sham procedure. Read More

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http://dx.doi.org/10.1007/s00395-018-0714-xDOI Listing
January 2019
3 Reads

Long-term prognosis of patients with systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study.

Eur Respir J 2019 Feb 14;53(2). Epub 2019 Feb 14.

Dept of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) confirmed by right heart catheterisation.A multicentre prospective cohort of SLE-associated PAH was established. Baseline and follow-up records were collected. Read More

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http://dx.doi.org/10.1183/13993003.00081-2018DOI Listing
February 2019
12 Reads
7.636 Impact Factor

Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial.

Nitric Oxide 2019 Mar 8;84:60-68. Epub 2019 Jan 8.

Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Indiana University School of Medicine, USA.

Objective: To test the hypothesis that adjunctive inhaled NO would improve RV function and viability in acute PE.

Methods: This was a randomized, placebo-controlled, double blind trial conducted at four academic hospitals. Eligible patients had acute PE without systemic arterial hypotension but had RV dysfunction and a treatment plan of standard anticoagulation. Read More

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http://dx.doi.org/10.1016/j.niox.2019.01.006DOI Listing
March 2019
3 Reads

Successful Treatment of Refractory Massive Pulmonary Embolism with Repeated Administration of Systemic Thrombolysis.

Tanaffos 2018 Feb;17(2):127-131

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: We report a case series of two patients in the intensive care unit with massive pulmonary embolism and obstructive shock who had resolution of shock after repeated administration of alteplase.

Case Summaries: Both patients were initially dosed 10 mg of alteplase followed by infusion of 90 mg over 2 hours, but remained in obstructive shock requiring significant inotropic and vasopressor support. Both patients were deemed poor candidates for embolectomy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320563PMC
February 2018
4 Reads

Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):482-495

From the Department of Pathophysiology, School of Basic Medicine (L.Z., R.X., X.Z., Y.L., F.L., Z.Y., S.L., Q.H.).

Objective- This study aims to determine whether and how the enriched metabolites of endothelial extracellular vesicles (eEVs) are critical for cigarette smoke-induced direct injury of endothelial cells and the development of pulmonary hypertension, rarely explored in contrast to long-investigated mechanisms secondary to chronic hypoxemia. Approach and Results- Metabonomic screen of eEVs from cigarette-smoking human subjects reveals prominent elevation of spermine-a polyamine metabolite with potent agonist activity for the extracellular CaSR (calcium-sensing receptor). CaSR inhibition with the negative allosteric modulator Calhex231 or CaSR knockdown attenuates cigarette smoke-induced pulmonary hypertension in rats without emphysematous changes in lungs or chronic hypoxemia. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312280DOI Listing
March 2019
10 Reads

Evaluating the effect of nasal septoplasty on atrial electromechanical features.

Am J Otolaryngol 2019 Mar - Apr;40(2):179-182. Epub 2018 Dec 15.

Otolaryngeaolgy, Duzce University Medical School, 81100 Duzce, Turkey.

Background: Recent studies have demonstrated that right ventricular (RV) dysfunction and increased pulmonary artery pressure may be frequent in patients with upper airway obstruction. In this study, we evaluated atrial conduction delays in patients with upper airway obstruction secondary to nasal septum deviation (NSD).

Methods: A total of 32 patients with upper airway obstruction secondary to NSD undergoing a septoplasty procedure were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.12.007DOI Listing
December 2018
2 Reads

Death or resolution: the "natural history" of pulmonary hypertension in bronchopulmonary dysplasia.

J Perinatol 2019 Mar 7;39(3):415-425. Epub 2019 Jan 7.

Pediatric Cardiology, Stanford University School of Medicine - Lucile Packard Children's Hospital, Stanford, Stanford, CA, USA.

Objectives: The primary objective was to describe the early "natural history" of pulmonary hypertension (PH) in the premature population. The secondary objective was to describe factors associated with poor outcomes in the premature population with PH at 36 weeks post-menstrual age (PMA).

Study Design: Retrospective chart review of patients followed at our institution from 2000 to 2017 with echocardiographic (ECHO) evidence of PH at 36 weeks PMA, and born ≤ 32 weeks estimated gestational age (GA). Read More

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http://dx.doi.org/10.1038/s41372-018-0303-8DOI Listing
March 2019
4 Reads