4,925 results match your criteria Pulmonary Hypertension Secondary


Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.

Front Immunol 2022 9;13:895501. Epub 2022 Jun 9.

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Introduction: Inflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc). The endothelin system and anti-endothelin A receptor (ET) autoantibodies have been implicated in the pathogenesis of PAH, and endothelin receptor antagonists are routinely used treatments for PAH. However, immunological functions of the endothelin B receptor (ET) remain obscure. Read More

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Sudden Onset of Severe Pulmonary Hypertension in a Preterm Infant: A Case Report on the Role of Maternal Use of Serotonin Re-Uptake Inhibitors During Pregnancy and Concurrent Risk Factors.

Front Pediatr 2022 10;10:855419. Epub 2022 Jun 10.

Division of Neonatal and Pediatric Intensive Care, Emergency Department, IRCCS Giannina Gaslini Institute, Genoa, Italy.

Persistent pulmonary hypertension of the newborn (PPHN) is a severe condition caused by failed circulatory adaptation at birth. Pulmonary hypertension is most common in full-term infants and rare in preterms, although it is increasingly diagnosed also in extremely preterm infants. Previous studies demonstrated the association between maternal use of selective serotonin re-uptake inhibitors during gestation and pulmonary hypertension. Read More

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Mortality prediction using a modified RCHADS-VASc score among hospitalized COVID-19 patients.

Intern Emerg Med 2022 Jun 25. Epub 2022 Jun 25.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

The CHADS-VASc score incorporates several comorbidities which have prognostic implications in COVID-19. We assessed whether a modified score (M-RCHADS-VASc), which includes pre-admission kidney function and male sex, could be used to classify mortality risk among people hospitalized with COVID-19. This retrospective study included adults admitted for COVID-19 between March and December 2020. Read More

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The Influence of Obesity Hypoventilation Syndrome on the Outcomes of Patients With Diabetic Ketoacidosis.

Cureus 2022 May 20;14(5):e25157. Epub 2022 May 20.

Internal Medicine, The Brooklyn Hospital Center, Brooklyn, USA.

Purpose: The effect of comorbid obesity hypoventilation syndrome (OHS) on hospitalized patients with diabetic ketoacidosis (DKA) has not been studied so far. This study elucidates the outcomes of DKA patients with OHS compared to those without OHS.

Methods: Patients above 18 years of age were included in the study. Read More

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The role of serial right heart catheterization in risk stratification and management of pulmonary arterial hypertension.

Expert Rev Cardiovasc Ther 2022 Jun 22:1-5. Epub 2022 Jun 22.

Department of Cardiology, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.

Introduction: Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary arterial blood pressure secondary to increased pulmonary vascular resistance.

Areas Covered: Invasive hemodynamic assessment by heart catheterization (RHC) remains the gold standard to confirm the diagnosis, to determine the severity of right ventricular dysfunction and to test for pulmonary vasoreactivity. After diagnosis and initiation of therapy, many PAH centers continue to perform RHC at regular intervals to monitor for disease progression and alter management. Read More

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Association of Obesity With COVID-19 Severity and Mortality: An Updated Systemic Review, Meta-Analysis, and Meta-Regression.

Front Endocrinol (Lausanne) 2022 3;13:780872. Epub 2022 Jun 3.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MI, United States.

Background: Obesity affects the course of critical illnesses. We aimed to estimate the association of obesity with the severity and mortality in coronavirus disease 2019 (COVID-19) patients.

Data Sources: A systematic search was conducted from the inception of the COVID-19 pandemic through to 13 October 2021, on databases including Medline (PubMed), Embase, Science Web, and Cochrane Central Controlled Trials Registry. Read More

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Bilateral Lung Transplantation for Congenital Pulmonary Arteriovenous Fistula with Intraoperative Venovenous ECMO Support: The First Case Report in China.

Front Surg 2022 31;9:861797. Epub 2022 May 31.

Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

Pulmonary arteriovenous fistula (PAVF) is a rare pulmonary vascular lesion, more than 80% of which is caused by congenital abnormal development of pulmonary capillaries. The incidence of PAVF ranges from 2/100,000 to 3/100,000, with no difference in the male and female ratio. Congenital PAVF is often associated with hereditary hemorrhagic telangiectasia (HHT). Read More

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Single Lung Transplant Remains a Viable Option for Patients With Severe Secondary Pulmonary Hypertension.

Transplantation 2022 Jun 6. Epub 2022 Jun 6.

Division of Cardiovascular Surgery, Department of Surgery, Temple University Hospital, Philadelphia, PA.

Background: Although double lung transplant is recommended in patients with severe secondary pulmonary hypertension (SPH), our institutional experiences suggest a role for single lung transplant in these patients. Here, we review our experience prioritizing single lung transplant in patients with SPH to minimize their surgical burden.

Methods: We conducted a retrospective review of our lung transplant database to identify patients with SPH who underwent single lung transplant. Read More

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A New Look at an Old Problem: Is Single Lung Transplantation an Option in Candidates With Significant Secondary Pulmonary Hypertension?

Transplantation 2022 Jun 6. Epub 2022 Jun 6.

Division of Pulmonary and Critical Care Medicine, University of Maryland, Baltimore, MD.

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Relation between endothelial nitric oxide synthase genetic polymorphisms and pulmonary arterial hypertension in newborns with congenital heart disease.

Clin Exp Hypertens 2022 Jun 14:1-6. Epub 2022 Jun 14.

Department of Medicine, Quanzhou Medical College, Quanzhou, P.R.China.

Objective: To investigate whether endothelial nitric oxide synthase () rs1799983, rs2070744, and rs61722009 gene polymorphisms are associated with pulmonary arterial hypertension (PAH) in South Fujian newborns with congenital heart disease (CHD).

Methods: Genotyping for the rs1799983, rs2070744, and rs61722009 polymorphisms was performed using Sanger sequencing in 50 newborns with PAH secondary to CHD [CHD PAH (+)], 52 newborns with CHD without PAH [CHD PAH (-)], and 60 healthy controls.

Results: The genotype and allele frequency distributions of rs1799983, rs2070744, and rs61722009 were similar between CHD and healthy controls ( > . Read More

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A 39-Year-Old Woman with Ventricular Electrical Storm Treated with Emergency Cardiac Defibrillation Followed by Multidisciplinary Management.

Am J Case Rep 2022 Jun 14;23:e935710. Epub 2022 Jun 14.

Department of Invasive Cardiology, Medical University of Białystok, Białystok, Poland.

BACKGROUND Ventricular electrical storm (VES) is a treatment-resistant ventricular arrhythmia associated with high mortality. This report is of a 39-year-old woman with VES treated with emergency cardiac defibrillation followed by multidisciplinary management. CASE REPORT A 39-year-old woman, previously diagnosed with eosinophilia of unknown origin and recurrent non-sustained ventricular tachycardias, was admitted to the Department of Invasive Cardiology with VES after an initial antiarrhythmic approach, analgesia, and defibrillation in the Emergency Department. Read More

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Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function.

J Crit Care 2022 Jun 10;71:154066. Epub 2022 Jun 10.

Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Although epidemiological studies have enhanced our understanding of acute kidney injury, defining the biologic processes corresponding to the clinical phenotype remains challenging. We have examined biomarkers associated with renal stress plus markers of glomerular function to assess whether this approach may aid prediction of AKI or other relevant endpoints.

Materials & Methods: Urinary [TIMP-2]·[IGFBP7], serum creatinine, plasma cystatin C and plasma proenkephalin 119-159 were analyzed in patients enrolled in the prospective, international, Sapphire study. Read More

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Advances in the Study of Inhaled Formulations for the Treatment of Pulmonary Arterial Hypertension.

Appl Bionics Biomech 2022 2;2022:6495645. Epub 2022 Jun 2.

The Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China.

Pulmonary arterial hypertension (PAH) is a serious disease with reduced systemic circulation and low bioavailability associated with conventional and dosed therapy, which inhaled drugs can avoid. A mean pulmonary artery pressure (mPAP) of ≥25 mmHg (1 mmHg = 0.133 kPa) at rest or ≥30 mmHg during exercise and a pulmonary capillary pressure or left atrial pressure (PLA) of ≤15 mmHg can be diagnosed with PAH. Read More

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Venoarterial Extracorporeal Membrane Oxygenation to Facilitate Transcutaneous Mitral Valve Replacement in Critical Mitral Stenosis.

JACC Case Rep 2022 Apr 6;4(7):385-390. Epub 2022 Apr 6.

Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.

Biological mitral valve restenosis after replacement in rheumatic heart disease is a rare complication. This case illustrates venoarterial extracorporeal membrane oxygenation to facilitate transcatheter mitral valve replacement in a patient with suprasystemic pulmonary pressure and cardiogenic shock with multiorgan failure secondary to critical mitral stenosis of a bioprosthetic valve.(). Read More

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Pulmonary vasodilator strategies in neonates with acute hypoxemic respiratory failure and pulmonary hypertension.

Semin Fetal Neonatal Med 2022 Jun 3:101367. Epub 2022 Jun 3.

Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO, United States; Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO, United States.

The management of acute hypoxemic respiratory failure (AHRF) in newborns continues to be a clinical challenge with elevated risk for significant morbidities and mortality, especially when accompanied with persistent pulmonary hypertension of the newborn (PPHN). PPHN is a syndrome characterized by marked hypoxemia secondary to extrapulmonary right-to-left shunting across the ductus arteriosus and/or foramen ovale with high pulmonary artery pressure and increased pulmonary vascular resistance (PVR). After optimizing respiratory support, cardiac performance and systemic hemodynamics, targeting persistent elevations in PVR with inhaled nitric oxide (iNO) therapy has improved outcomes of neonates with PPHN physiology. Read More

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Outcomes for Children With Pulmonary Hypertension Undergoing Tracheostomy Placement: A Multi-Institutional Analysis.

Pediatr Crit Care Med 2022 Jun 10. Epub 2022 Jun 10.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA.

Objectives: To describe epidemiology, interventions, outcomes, and the health services experience for a cohort of children with pulmonary hypertension (PH) who underwent tracheostomy placement and to identify risk factors for inhospital mortality and 30-day readmissions.

Design: Retrospective cohort study of the Pediatric Health Information System database.

Setting: Thirty-seven freestanding U. Read More

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A Systematic Review on Pulmonary Complications Secondary to Hematopoietic Stem Cell Transplantation.

Cureus 2022 May 7;14(5):e24807. Epub 2022 May 7.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

The main purpose of this systematic review was to identify and synthesize evidence about pulmonary complications following stem cell transplantation to raise awareness among physicians since it is a lesser-known topic. Studies that included targeted pulmonary complications that occurred after stem cell transplantation; in humans; and were randomized controlled trials, cohort studies, and case studies between January 2011 and 2021. Fifteen intervention features were identified and analyzed in terms of their association with successful or unsuccessful interventions. Read More

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Bioinformatic analysis of dysregulated circular RNAs in pediatric pulmonary hypertension linked congenital heart disease.

Transl Pediatr 2022 May;11(5):715-727

Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: Circular RNAs (circRNAs) may play important roles in the progression of pulmonary arterial hypertension. However, the potential roles they play in childhood pulmonary arterial hypertension associated congenital heart disease (CHD) progression remains unclear.

Methods: Thirteen human plasma samples including eight from pulmonary arterial hypertension secondary to CHD patients and five from a control group were analyzed using the Arraystar Human circRNA array. Read More

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Meta-Analysis of Percutaneous Endomyocardial Cell Therapy in Patients with Ischemic Heart Failure by Combination of Individual Patient Data (IPD) of ACCRUE and Publication-Based Aggregate Data.

J Clin Med 2022 Jun 4;11(11). Epub 2022 Jun 4.

Department of Cardiology, University Heart and Vascular Center UKE Hamburg, 20246 Hamburg, Germany.

Individual patient data (IPD)-based meta-analysis (ACCRUE, meta-analysis of cell-based cardiac studies, NCT01098591) revealed an insufficient effect of intracoronary cell-based therapy in acute myocardial infarction. Patients with ischemic heart failure (iHF) have been treated with reparative cells using percutaneous endocardial, surgical, transvenous or intracoronary cell delivery methods, with variable effects in small randomized or cohort studies. The objective of this meta-analysis was to investigate the safety and efficacy of percutaneous transendocardial cell therapy in patients with iHF. Read More

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Variation in Use of High-Flow Nasal Cannula and Noninvasive Ventilation Among Patients With COVID-19.

Respir Care 2022 Jun 7. Epub 2022 Jun 7.

Evans Center of Implementation and Improvement Sciences, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.

Background: The use of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) for hypoxemic respiratory failure secondary to coronavirus disease 2019 (COVID-19) are recommended by critical-care guidelines; however, apprehension about viral particle aerosolization and patient self-inflicted lung injury may have limited use. We aimed to describe hospital variation in the use and clinical outcomes of HFNC and NIV for the management of COVID-19.

Methods: This was a retrospective observational study of adults hospitalized with COVID-19 who received supplemental oxygen between February 15, 2020, and April 12, 2021, across 102 international and United States hospitals by using the COVID-19 Registry. Read More

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Association of pulmonary hypertension with survival and neurologic outcomes in adults with in-hospital cardiac arrest.

Resuscitation 2022 Jun 6. Epub 2022 Jun 6.

Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA.

Background: Pulmonary hypertension (PH) has been associated with poor survival in multiple cardiopulmonary conditions, however its association with outcomes in cardiac arrest remains unknown. We aimed to evaluate the association of PH with survival and neurologic outcomes in adults with in-hospital cardiac arrest (IHCA).

Methods: The study population included adults with IHCA undergoing resuscitation at an academic tertiary-care medical center from 2011 to 2019. Read More

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Case Report: Septic Pericarditis With in an Immunosuppressed Dog.

Front Vet Sci 2022 18;9:884654. Epub 2022 May 18.

Department of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, United States.

A 5-year-old female spayed French Bulldog presented for anorexia and increased respiratory rate. On presentation, she was dyspneic with stridor and increased bronchovesicular sounds. Point-of-care ultrasound identified pericardial effusion. Read More

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Predictors of peri-operative cardiac events and development of a scoring tool for patients with chronic kidney disease undergoing non-cardiac surgeries: A prospective observational multicentre study.

Indian J Anaesth 2022 Apr 20;66(4):278-289. Epub 2022 Apr 20.

Department of Anaesthesiology, NU Hospitals, Bengaluru, Karnataka, India.

Background And Aims: Cardiovascular diseases are the leading causes of morbidity and mortality in chronic kidney disease (CKD) patients. Our aim was to derive predictors of cardiac morbidity, mortality, cardiac complications and to develop/validate a scoring tool in patients with CKD undergoing non-cardiac surgery.

Methods: A prospective observational multicentre study was done on 770 patients with CKD. Read More

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A case of severe cancer-related pulmonary hypertension; An unexpected resolution.

Respir Med Case Rep 2022 23;38:101671. Epub 2022 May 23.

Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY, USA.

Pulmonary hypertension (PH) in cancer patients can be caused by several mechanisms. It can be a direct cancer effect through pulmonary tumor thrombotic microangiopathy, pulmonary tumor emboli, extrinsic compression, intravascular tumors, or a secondary consequence of therapy, including chemotherapy agents, radiation, and stem cell transplantation. We present the first case of complete resolution of cancer-related PH. Read More

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Homozygous Factor V Leiden Complicated by Heparin-Induced Thrombocytopenia: A Case Report.

J Med Cases 2022 May 23;13(5):225-228. Epub 2022 Apr 23.

Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

Homozygous factor V Leiden (FVL) is a rare condition, occurring in 0.2% of the white population. This disease's rarity and aggressive pathophysiology can represent a challenge even to the most experienced clinicians. Read More

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Pulmonary hypertension in patients with pneumoconiosis with progressive massive fibrosis.

Occup Environ Med 2022 Jun 2. Epub 2022 Jun 2.

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital Capital Medical University, Beijing, China

Objectives: This study aims to explore the prevalence and clinical features of pulmonary hypertension (PH) in patients with progressive massive fibrosis (PMF) and its correlation with large opacities on CT scans.

Methods: This retrospective study collected 235 patients with PMF, and 199 were eligible for analysis. The probability of PH development was estimated based on tricuspid regurgitation velocity measured by echocardiogram. Read More

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Association between smoking and postoperative delirium in surgical patients with pulmonary hypertension: a secondary analysis of a cohort study.

BMC Psychiatry 2022 06 1;22(1):371. Epub 2022 Jun 1.

Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.

Background: Previous studies have declared that smoking was a risk factor for postoperative delirium (POD), but others have inconsistent results. Up till now, the association between smoking and POD has not been verified. This study investigates the relationship between smoking and POD in patients with pulmonary hypertension (PHTN) in the United States. Read More

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Various factors contribute to death in patients with different types of pulmonary hypertension: A retrospective pilot study from a single tertiary center.

Respir Investig 2022 May 26. Epub 2022 May 26.

Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, 060-8638, Japan; Division of Respiratory and Cardiovascular Innovative Research, Faculty of Medicine, Hokkaido University, Sapporo, 060-8638, Japan.

Background: A few studies have focused on the cause of death from different types of pulmonary hypertension (PH). This study aimed to systematically analyze the primary and secondary causes of death and compare the profiles between different PH groups.

Methods: The contribution of PH to death was assessed in precapillary PH (i. Read More

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Hypertension control in Kerala, India: A prescription-based study at primary and secondary level health care institutions.

Indian Heart J 2022 May 27. Epub 2022 May 27.

Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, 695011, India; Health Action by People, Thiruvananthapuram, Kerala, 695011, India. Electronic address:

Objective: We undertook a prescription-based study to identify the provider and institution-level factors related to achieving guideline-recommended control of hypertension and diabetes mellitus in Kerala, India.

Methods: This cross-sectional study in primary and secondary care hospitals in Kerala included both public and private institutions. One practitioner was selected from each institution. Read More

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Chronic Thromboembolic Pulmonary Hypertension.

Lung 2022 Jun 29;200(3):283-299. Epub 2022 May 29.

Division of Biological Sciences, Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

Chronic thromboembolic pulmonary hypertension (CTEPH), defined as precapillary pulmonary hypertension (PH) by right heart catheterization and imaging consistent with chronic thromboembolism, is a long-term complication of pulmonary embolism (PE). Pathobiological mechanisms involve pulmonary artery occlusion from organized thromboembolic material despite at least three months of uninterrupted therapeutic anticoagulation following acute PE and secondary microvasculopathy. Delay in diagnosis and management of CTEPH is associated with poor outcomes. Read More

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