7,838 results match your criteria Pulmonary Hypertension Primary


Idiopathic, heritable and veno-occlusive pulmonary arterial hypertension in childhood: computed tomography angiography features in the initial assessment of the disease.

Pediatr Radiol 2019 Jan 16. Epub 2019 Jan 16.

M3C-Necker, Congenital and Pediatric Cardiology, Hôpital Universitaire Necker-Enfants malades, Paris, France.

Background: In children, idiopathic and heritable pulmonary arterial hypertension present echocardiographic and heart catheterization findings similar to findings in pulmonary veno-occlusive disease.

Objective: To provide a systematic analysis of CT angiography anomalies in children with idiopathic or heritable pulmonary arterial hypertension, or pulmonary veno-occlusive disease. We also sought to identify correlations between CT findings and patients' baseline characteristics. Read More

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http://dx.doi.org/10.1007/s00247-018-04331-yDOI Listing
January 2019

Chronic kidney disease predicts atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.

Acta Cardiol 2019 Jan 16:1-8. Epub 2019 Jan 16.

a University of Medicine and Pharmacy of Tîrgu Mureș , Tîrgu Mureș , Romania.

Background: Atrial fibrillation (AF) often complicates ST-segment elevation myocardial infarction (STEMI). Predictors of AF in this setting include factors related to the acute phase of STEMI and pre-existing conditions. More recently, novel AF predictors have been identified in the general population. Read More

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http://dx.doi.org/10.1080/00015385.2018.1521558DOI Listing
January 2019

Differences in clinical characteristics and one-year outcomes of hospitalized heart failure patients in succeeding European Society of Cardiology-Heart Failure Registries - Pilot and Long-Term.

Pol Arch Intern Med 2019 Jan 16. Epub 2019 Jan 16.

INTRODUCTION The management of heart failure (HF) has significantly changed in recent decades. OBJECTIVES The paper analyzes clinical profile, one-year outcomes, predictors of mortality and hospital readmissions in hospitalized patients enrolled in the European Society of Cardiology HF-Pilot (ESC-HF-Pilot) and HF-Long Term (ESC-HF-LT) Registries. PATIENTS AND METHODS The analysis included hospitalized Polish patients from the ESC-HF-Pilot and ESC-HF-LT Registries. Read More

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http://dx.doi.org/10.20452/pamw.4418DOI Listing
January 2019

Rate of instrumentation changes on postoperative and follow-up radiographs after primary complex spinal fusion (five or more levels) for adult deformity correction.

J Neurosurg Spine 2019 Jan 11:1-6. Epub 2019 Jan 11.

2Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.

OBJECTIVEIn the United States, healthcare expenditures have been soaring at a concerning rate. There has been an excessive use of postoperative radiographs after spine surgery and this has been a target for hospitals to reduce unnecessary costs. However, there are only limited data identifying the rate of instrumentation changes on radiographs after complex spine surgery involving ≥ 5-level fusions. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18686DOI Listing
January 2019

Impact of preoperative pulmonary arterial hypertension on early and late outcomes in patients undergoing valve surgery for rheumatic heart disease.

Indian J Anaesth 2018 Dec;62(12):963-971

Department of Cardiac Anesthesia, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India.

Background And Aims: There is conflicting evidence on adverse effect of Pulmonary Arterial Hypertension (PAH) on outcomes after cardiac surgery for rheumatic heart disease (RHD). The authors studied Indian patients with RHD and preoperative PAH, who undergo cardiac surgery with a hypothesis that they have poor short and long-term outcomes.

Methods: This was a retrospective observational study of 407 patients. Read More

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http://dx.doi.org/10.4103/ija.IJA_374_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299764PMC
December 2018

Increased Expression of MicroRNA-206 Inhibits Potassium Voltage-Gated Channel Subfamily A Member 5 in Pulmonary Arterial Smooth Muscle Cells and Is Related to Exaggerated Pulmonary Artery Hypertension Following Intrauterine Growth Retardation in Rats.

J Am Heart Assoc 2019 Jan;8(2):e010456

2 Department of Neonatology the Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province People's Republic of China.

Background Intrauterine growth retardation ( IUGR ) is related to pulmonary artery hypertension in adults, and mi croRNA -206 (miR-206) is proposed to affect the proliferation and apoptosis of pulmonary artery smooth muscle cells ( PASMC s) via post-transcriptional regulation. Methods and Results In an IUGR rat model, we found that the expression and function of potassium voltage-gated channel subfamily A member 5 (Kv1.5) in PASMC s was inhibited, and pulmonary artery hypertension was exaggerated after chronic hypoxia ( CH ) treatment as adults. Read More

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http://dx.doi.org/10.1161/JAHA.118.010456DOI Listing
January 2019

Long-Term Prognosis of Patients with Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension: CSTAR-PAH Cohort Study.

Eur Respir J 2019 Jan 11. Epub 2019 Jan 11.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China

This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with SLE-associated PAH confirmed by right heart catheterisation. A multicenter prospective cohort of SLE-associated PAH was established. Baseline and follow-up records were collected. Read More

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http://dx.doi.org/10.1183/13993003.00081-2018DOI Listing
January 2019
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7.636 Impact Factor

Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial.

Nitric Oxide 2019 Jan 8. Epub 2019 Jan 8.

Associate Professor of Medicine, Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Indiana University School of Medicine, USA.

Objective: To test the hypothesis that adjunctive inhaled NO would improve RV function and viability in acute PE.

Methods: This was a randomized, placebo-controlled, double blind trial conducted at four academic hospitals. Eligible patients had acute PE without systemic arterial hypotension but had RV dysfunction and a treatment plan of standard anticoagulation. Read More

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http://dx.doi.org/10.1016/j.niox.2019.01.006DOI Listing
January 2019

Selexipag treatment for pulmonary arterial hypertension associated with congenital heart disease after defect correction: insights from the randomised controlled GRIPHON study.

Eur J Heart Fail 2019 Jan 11. Epub 2019 Jan 11.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University Hospital, Bologna, Italy.

Aims: Patients with pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) after defect correction have a poor prognosis compared with other CHD-PAH patients. Therefore, it is important that these patients are treated as early and effectively as possible. Evidence supporting the use of PAH therapies in patients with corrected CHD-PAH from randomised controlled trials is limited. Read More

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http://doi.wiley.com/10.1002/ejhf.1375
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http://dx.doi.org/10.1002/ejhf.1375DOI Listing
January 2019
2 Reads

Hyperthyroidism with Biventricular Heart Failure and Cirrhotic Transformation of the Liver.

Case Rep Cardiol 2018 9;2018:3861340. Epub 2018 Dec 9.

Reading Hospital, Tower Health System, West Reading, PA, USA.

Cardiovascular symptoms remain the most common presenting features and leading causes of death in hyperthyroidism. We report a young female with reported thyroid disease and medication noncompliance presenting with atrial fibrillation, severe atrioventricular regurgitation, severely dilated right heart with reduced function, and moderate pulmonary hypertension (PH), which was further complicated by congestive liver injury with ascites and pancytopenia. Thyroid work-up revealed suppressed TSH, elevated free T4 and T3 along with elevated anti-thyroglobulin antibodies, thyroid peroxidase antibodies, and thyroid-stimulating immunoglobulin, suggesting Graves' thyrotoxicosis. Read More

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http://dx.doi.org/10.1155/2018/3861340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305034PMC
December 2018

Pulmonary Tumor Thrombotic Microangiopathy Mimicking Inhalation Lung Injury: A Case Report.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of Pulmonology, Kameda Medical Center, Japan.

Pulmonary tumor thrombotic microangiopathy (PTTM) is a complication characterized by dyspnea, pulmonary hypertension, and occasionally sudden death. We encountered a man who developed PTTM and had an inhalation history of chemical herbicides and abnormal findings on chest computed tomography, mimicking chemical inhalation lung injury. He was diagnosed with PTTM with adenocarcinoma by a transbronchial lung biopsy and received chemotherapy and anticoagulant therapy. Read More

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http://dx.doi.org/10.2169/internalmedicine.1796-18DOI Listing
January 2019

Is Obesity Associated With Increased Risk of Deep Vein Thrombosis or Pulmonary Embolism After Hip and Knee Arthroplasty? A Large Database Study.

Clin Orthop Relat Res 2019 Jan 3. Epub 2019 Jan 3.

M. Sloan, G.-C. Lee Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA N. Sheth Department of Orthopaedic Surgery, Pennsylvania Hospital, Philadelphia, PA, USA.

Background: Deep venous thrombosis (DVT) and pulmonary embolus (PE) remain an important cause of morbidity and mortality after THA and TKA. Prior recommendations have advocated for more aggressive prophylaxis for patients with obesity, whereas the evidence supporting these recommendations is conflicting and often based on underpowered studies.

Questions/purposes: (1) What is the association between obesity and DVT and PE after primary and revision THA and TKA? (2) Is there a body mass index (BMI) threshold beyond which DVT and PE risk is elevated?

Methods: We reviewed the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2008 to 2016 to evaluate the reported 30-day rates of DVT, PE, and combined venous thromboembolism (VTE) after primary THA, primary TKA, revision THA, and revision TKA according to BMI as a continuous variable and a categorical variable as defined by the World Health Organization cutoffs for underweight, normal weight, overweight, and obesity. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000615DOI Listing
January 2019
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Death or resolution: the "natural history" of pulmonary hypertension in bronchopulmonary dysplasia.

J Perinatol 2019 Jan 7. Epub 2019 Jan 7.

Pediatric Cardiology, Stanford University School of Medicine - Lucile Packard Children's Hospital, Stanford, Stanford, CA, USA.

Objectives: The primary objective was to describe the early "natural history" of pulmonary hypertension (PH) in the premature population. The secondary objective was to describe factors associated with poor outcomes in the premature population with PH at 36 weeks post-menstrual age (PMA).

Study Design: Retrospective chart review of patients followed at our institution from 2000 to 2017 with echocardiographic (ECHO) evidence of PH at 36 weeks PMA, and born ≤ 32 weeks estimated gestational age (GA). Read More

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http://dx.doi.org/10.1038/s41372-018-0303-8DOI Listing
January 2019

Association between asthma-COPD overlap syndrome and healthcare utilizations among US adult population.

Curr Med Res Opin 2019 Jan 5. Epub 2019 Jan 5.

a Center for Outcomes Research, University of Illinois College of Medicine at Peoria , Peoria , Illinois.

Objectives: Asthma- Chronic Obstructive Pulmonary Disease (COPD) overlap (ACO) was a recently described phenomenon defined as the coexistence of both asthma and COPD. Both asthma and COPD were known to result in increased emergency department (ED) visits and hospitalizations, but it was unclear how the ACO population utilizes these same healthcare resources. The objective of this study was to compare healthcare utilization in the ACO population, versus the general population, the asthma population, and the COPD population. Read More

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http://dx.doi.org/10.1080/03007995.2019.1565531DOI Listing
January 2019

HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.

Vascul Pharmacol 2019 Jan 2. Epub 2019 Jan 2.

Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha 410008, China; Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha 410000, China. Electronic address:

High mobility group box 1 (HMGB1), a critical nonclassical inflammatory cytokine, has been found up-regulated in patients with idiopathic pulmonary arterial hypertension (IPAH), but its role in vascular remodeling of pulmonary hypertension (pH) is still unknown. In present study, we demonstrated that the plasma level of inflammatory cytokine including HMGB1, interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were elevated in hypoxia-induced pulmonary hypertension rats model. Moreover, expressions of HMGB1 and Toll like receptor-4 (TLR4) in pulmonary arteries were obviously up-regulated accompanied with down-regulation of bone morphogenetic protein receptor 2 (BMPR2) signaling, characterized by decline of phosphorylated Smad1/5/8 (p-Smsd1/5/8) and inhibitor of differention 1 (Id1) expression. Read More

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http://dx.doi.org/10.1016/j.vph.2018.12.006DOI Listing
January 2019

Rho signaling pathway enhances proliferation of by suppressing nuclear translocation of Smad1 in PAH.

Exp Ther Med 2019 Jan 8;17(1):71-78. Epub 2018 Nov 8.

Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.

Bone morphogenetic protein (BMP) and Rho kinase signaling pathways exert counter regulatory effects on pulmonary artery smooth muscle cell (PASMC) proliferation in pulmonary artery hypertension (PAH). To elucidate the mechanism of this interaction, the present study tested whether Rho kinase activated by platelet derived growth factor-BB (PDGF-BB) enhances PASMC proliferation by suppressing the nuclear translocation of Smad1 induced by BMP-2. BMP-2 was used to activate the Smad1 signaling pathway and PDGF-BB was used to activate the Rho kinase signaling pathway when cells were pretreated with or without Rho-associated protein kinase (ROCK) inhibitor Y-27632 or dual specificity mitogen-activated protein kinase kinase (MEK) 1 and 2 inhibitor U0126. Read More

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http://dx.doi.org/10.3892/etm.2018.6942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307528PMC
January 2019

Rationale and design of TransplantLines: a prospective cohort study and biobank of solid organ transplant recipients.

BMJ Open 2018 Dec 31;8(12):e024502. Epub 2018 Dec 31.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Introduction: In the past decades, short-term results after solid organ transplantation have markedly improved. Disappointingly, this has not been accompanied by parallel improvements in long-term outcomes after transplantation. To improve graft and recipient outcomes, identification of potentially modifiable risk factors and development of biomarkers are required. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318532PMC
December 2018
2 Reads

Decreased biventricular longitudinal strain in patients with systemic sclerosis is mainly caused by pulmonary hypertension and not by systemic sclerosis per se.

Clin Physiol Funct Imaging 2018 Dec 31. Epub 2018 Dec 31.

Department of Clinical Sciences Lund, Clinical Physiology, Skåne University Hospital, Lund University, Lund, Sweden.

Purpose: Patients with pulmonary arterial hypertension (PAH) due to systemic sclerosis (SSc) have high mortality. Left ventricular (LV) peak global longitudinal strain (GLS) is decreased in SSc. It is unknown whether low GLS is due to SSc or PAH. Read More

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http://doi.wiley.com/10.1111/cpf.12561
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http://dx.doi.org/10.1111/cpf.12561DOI Listing
December 2018
1 Read

[Extracorporeal membrane oxygenation as a bridge to lung transplantation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1167-1172

Department of Intensive Care Unit, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi 214023, Jiangsu, China (Xia W, Xu HY); Department of Thoracic Surgery, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi 214023, Jiangsu, China (Mao WJ, Chen JY). Corresponding author: Xu Hongyang, Email:

Objective: To evaluate the effect of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation (LTx).

Methods: The clinical data of 18 patients with end-stage lung diseases was retrospectively reviewed, using ECMO as a bridge to LTx in intensive care unit of Affiliated Wuxi People's Hospital from January 2015 to December 2017. Clinical parameters were obtained from these patients, including gender, age, primary disease, preoperative lactate level, preoperative leukocyte, operation modality (unilateral or bilateral), type of ECMO, ECMO support time as a bridge to LTx, ECMO support time after operation, total usage time of ECMO, ECMO associated complications, primary graft dysfunction (PGD), successful ECMO weaning, and survival. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.013DOI Listing
December 2018
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XANTUS-EL: A real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation in Eastern Europe, Middle East, Africa and Latin America.

Egypt Heart J 2018 Dec 24;70(4):307-313. Epub 2018 Sep 24.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: The prospective, observational XANTUS study demonstrated low rates of stroke and major bleeding in real-world rivaroxaban-treated patients with non-valvular atrial fibrillation (NVAF) from Western Europe, Canada and Israel. XANTUS-EL is a component of the overall XANTUS programme and enrolled patients with NVAF treated with rivaroxaban from Eastern Europe, the Middle East and Africa (EEMEA) and Latin America.

Methods: Patients with NVAF starting rivaroxaban for stroke prevention were consecutively recruited and followed for 1 year, at approximately 3-month intervals, or for ≥30 days after permanent rivaroxaban discontinuation. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303362PMC
December 2018

Evaluation of Macitentan in Patients With Eisenmenger Syndrome.

Circulation 2019 Jan;139(1):51-63

Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Italy (N.G.).

Background: Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macitentan in Eisenmenger Syndrome to Restore Exercise Capacity) evaluated the efficacy and safety of the endothelin receptor antagonist macitentan in patients with Eisenmenger syndrome.

Methods: Patients with Eisenmenger syndrome aged ≥12 years and in World Health Organization functional class II-III were randomized 1:1 to placebo or macitentan 10 mg once daily for 16 weeks. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033575DOI Listing
January 2019
1 Read

The β-Adrenergic Agonist Albuterol Improves Pulmonary Vascular Reserve in Heart Failure With Preserved Ejection Fraction.

Circ Res 2019 Jan;124(2):306-314

From the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.

Rationale: Pulmonary vascular resistance fails to decrease appropriately during exercise in patients with heart failure with preserved ejection fraction (HFpEF). Interventions that enhance pulmonary vasodilation might be beneficial in this cohort but could also worsen left atrial hypertension, exacerbating lung congestion. Intravenous β-agonists reduce pulmonary vascular resistance but are not suitable for chronic use. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313832DOI Listing
January 2019

Granular cell tumor of the lung.

Diagn Cytopathol 2018 Dec 23. Epub 2018 Dec 23.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

A 46-year-old female with history of asthma, active smoking (20 pack-years), and schizophrenia was evaluated for a persistent asymptomatic pulmonary nodule. Her past medical history was notable for hypertension, obesity, polycystic ovary syndrome, abnormal uterine bleeding, multinodular thyroid gland, and vitamin D deficiency. Seven months before presentation, a chest radiograph (CXR) was obtained to evaluate unintended weight loss, and showed a 3 cm spiculated mass in the left lower lobe concerning for a primary lung malignancy. Read More

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http://dx.doi.org/10.1002/dc.24112DOI Listing
December 2018
2 Reads

Aqp-1 Gene Knockout Attenuates Hypoxic Pulmonary Hypertension of Mice.

Arterioscler Thromb Vasc Biol 2019 Jan;39(1):48-62

From the The Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, China (M.L., Q.L., Y.P., M.G., J.P., X.Y., H.Z., Y.C., J.S., L.W., X.Z., R.W., Y.D., Y.Y.).

Objective- Hypoxic pulmonary hypertension (HPH) is characterized by proliferative vascular remodeling. Abnormal pulmonary artery smooth muscle cells proliferation and endothelial dysfunction are the primary cellular bases of vascular remodeling. AQP1 (aquaporin-1) is regulated by oxygen level and has been observed to play a role in the proliferation and migration of pulmonary artery smooth muscle cells. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311714DOI Listing
January 2019
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The prognostic value of various biomarkers in adults with pulmonary hypertension; a multi-biomarker approach.

Am Heart J 2018 Nov 24;208:91-99. Epub 2018 Nov 24.

Department of Cardiology, Erasmus Medical Centre, Rotterdam, the Netherlands. Electronic address:

Background: This study aimed to investigate the prognostic value of six different biomarkers in patients with pulmonary hypertension (PH) and to explore whether a multi-biomarker approach can contribute to a better risk stratification.

Methods: In this prospective study, patients with PH were included at the day of the diagnostic right heart catheterization between May 2012 and October 2016. Venous blood sampling included; NT-proBNP, high sensitive troponin-T, high sensitive CRP, galectin-3, red blood cell distribution width and eGFR. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.11.001DOI Listing
November 2018
1 Read

The effect of rapid infusion of cisplatin on nephrotoxicity in patients with lung carcinoma.

J Clin Pharm Ther 2018 Dec 21. Epub 2018 Dec 21.

Department of Pharmacy, OLVG Hospital, Amsterdam, The Netherlands.

What Is Known And Objective: The use of cisplatin in the treatment of lung carcinoma is limited by nephrotoxicity. The aim of this study was to determine whether the incidence of nephrotoxicity in patients with lung carcinoma is affected by the infusion rate of cisplatin (rapid infusion of cisplatin in 1 hour compared to regular infusion in 3 hours).

Methods: This observational, retrospective study was performed on patients diagnosed with non-small-cell lung carcinoma (NSCLC), small-cell lung carcinoma (SCLC) or mesothelioma receiving a cisplatin-containing chemotherapy regimen. Read More

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http://dx.doi.org/10.1111/jcpt.12781DOI Listing
December 2018
1 Read

Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension.

Circ Cardiovasc Imaging 2018 Nov;11(11):e006984

Division of Cardiology, Department of Medicine (F.A., A.M., E.J.V., P.S.D., Z.S., S.R.), Duke University Medical Center, Durham, NC.

Background Although right atrial (RA) enlargement is an established marker for adverse outcomes, the prognostic importance of RA dysfunction independent of RA size in pulmonary arterial hypertension is not known. Methods and Results Study subjects with pulmonary arterial hypertension were prospectively enrolled from 2010 to 2014. RA function was measured using RA speckle-tracking longitudinal strain and strain rate (SR) during each phase of the cardiac cycle: (1) RA reservoir (peak longitudinal strain, peak systolic SR), (2) RA conduit (peak early diastolic SR), and (3) RA active contraction (peak active contraction strain, peak contraction SR). Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.117.006984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309911PMC
November 2018

Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients.

Circ Genom Precis Med 2018 Nov;11(11):e002234

Research Programs Unit, Diabetes and Obesity, University of Helsinki, Finland. (P.W.).

Background: Integration of systems-level biomolecular information with electronic health records has led to recent interest in the glycoprotein acetyls (GlycA) biomarker-a serum- or plasma-derived nuclear magnetic resonance spectroscopy signal that represents the abundance of circulating glycated proteins. GlycA predicts risk of diverse outcomes, including cardiovascular disease, type 2 diabetes mellitus, and all-cause mortality; however, the underlying detailed associations of GlycA's morbidity and mortality risk are currently unknown.

Methods: We used 2 population-based cohorts totaling 11 861 adults from the Finnish general population to test for an association with 468 common incident hospitalization and mortality outcomes during an 8-year follow-up. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002234DOI Listing
November 2018
2 Reads

Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort.

Arthritis Res Ther 2018 Dec 19;20(1):280. Epub 2018 Dec 19.

Complexo Hospitalario Universitario de Vigo, Vigo, Spain.

Background: The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

Methods: All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology [SER], cross-sectional phase) registry were retrospectively investigated for the presence of primary pleuropulmonary manifestations.

Results: In total 3215 patients were included. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1776-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299951PMC
December 2018
5 Reads

Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial.

Clin Res Cardiol 2018 Dec 18. Epub 2018 Dec 18.

Center for Thrombosis and Hemostasis, University Medical Center, Langenbeckstrasse 1, Mainz, Germany.

Introduction: Symptoms and functional limitation are frequently reported by survivors of acute pulmonary embolism (PE). However, current guidelines provide no specific recommendations on which patients should be followed after acute PE, when follow-up should be performed, and which tests it should include. Definition and classification of late PE sequelae are evolving, and their predictors remain to be determined. Read More

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http://dx.doi.org/10.1007/s00392-018-1405-1DOI Listing
December 2018
1 Read
4.560 Impact Factor

Management of Older Patients With Metastatic Renal Cell Carcinoma Receiving Sunitinib: A Hypothetical, Illustrative Case Scenario.

J Adv Pract Oncol 2018 Jan-Feb;9(1):67-76. Epub 2018 Jan 1.

Duke Prostate Center, Durham, North Carolina.

Tom, a 75-year-old white male, was recently diagnosed with metastatic renal cell carcinoma (RCC; Tom's case is not an actual clinical case but has been developed by the authors as an exemplar). Two years prior, he had undergone a left partial (laparoscopic) nephrectomy for clear cell RCC. At that time, he had a stage 3 disease (the tumor extended into perinephric tissues but not into the ipsilateral adrenal gland and not beyond Gerota's fascia [Cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296420PMC
January 2018
2 Reads

Cardiac autotransplantation and ex vivo surgical repair of giant left atrium: a case presentation.

BMC Cardiovasc Disord 2018 Dec 18;18(1):239. Epub 2018 Dec 18.

Zan Mitrev Clinic, Bledski Dogovor 8, Skopje, 1000, Republic of Macedonia.

Background: Chronic Mitral Valve disease is strongly associated with Left atrial enlargement; the condition has a high mortality risk. Clinical manifestations include atrial fibrillation, pulmonary hypertension, thromboembolic events, and in cases of Giant Left Atrium (GLA) and a distorted cardiac silhouette. Full sternotomy, conventional open-heart surgery, reductive atrioplasty and atrioventricular valve repair are required to resolve symptoms. Read More

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http://dx.doi.org/10.1186/s12872-018-0966-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299545PMC
December 2018

Cirrhosis associated with decreased survival and a 10-year lower median age at death of cystic fibrosis patients in the Netherlands.

J Cyst Fibros 2018 Dec 14. Epub 2018 Dec 14.

The University Medical Center Groningen, Dept. of Pediatrics, University of Groningen, Groningen, the Netherlands, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. Electronic address:

Background: Up to 10% of patients with Cystic Fibrosis develop cirrhotic CF-related liver disease with portal hypertension: CF cirrhosis (CFC). In a nationwide study, we aimed to determine the role of CFC on survival in the Netherlands between 1 and 1-2009 and1-1-2015.

Methods: We identified all CFC patients in the Netherlands, based on ultrasonographic liver nodularity and portal hypertension. Read More

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http://dx.doi.org/10.1016/j.jcf.2018.11.009DOI Listing
December 2018
1 Read

Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension.

Thorax 2019 Feb 15;74(2):164-176. Epub 2018 Dec 15.

National Heart and Lung Institute, Imperial College London, London, UK.

Introduction: Skeletal muscle dysfunction is a clinically important complication of pulmonary arterial hypertension (PAH). Growth/differentiation factor 15 (GDF-15), a prognostic marker in PAH, has been associated with muscle loss in other conditions. We aimed to define the associations of GDF-15 and muscle wasting in PAH, to assess its utility as a biomarker of muscle loss and to investigate its downstream signalling pathway as a therapeutic target. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2017-211440DOI Listing
February 2019

TAKling GDF-15 and skeletal muscle atrophy in pulmonary hypertension: are we there yet?

Thorax 2019 Feb 15;74(2):103-105. Epub 2018 Dec 15.

Division of Pulmonary, Allergy and Critical Care, Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-2126
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http://dx.doi.org/10.1136/thoraxjnl-2018-212680DOI Listing
February 2019
4 Reads

Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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http://link.springer.com/10.1007/s10995-018-2652-5
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http://dx.doi.org/10.1007/s10995-018-2652-5DOI Listing
December 2018
4 Reads

Characterization of Right Ventricular Deformation in Pulmonary Arterial Hypertension Using Three-Dimensional Principal Strain Analysis.

J Am Soc Echocardiogr 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada. Electronic address:

Background: Pulmonary arterial hypertension (PAH) can cause maladaptive right ventricular (RV) functional changes associated with adverse prognosis that are challenging to accurately quantify noninvasively. The aim of this study was to explore principal strain (PS) with contraction angle analysis using three-dimensional echocardiography to characterize RV deformation changes in patients with PAH.

Methods: Three-dimensional echocardiography was performed in 37 patients with PAH and 20 healthy control subjects with two-component (primary and secondary) PS and principal contraction angle analysis. Read More

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http://dx.doi.org/10.1016/j.echo.2018.10.001DOI Listing
December 2018
1 Read
4.056 Impact Factor

Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Neonatology, Department of Paediatrics, CHU de Québec, Université Laval, Québec City, Québec, Canada.

Background:  Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% of neonatal respiratory insufficiency. To selectively reduce pulmonary vascular resistance, several treatments have been tried. Inhaled epoprostenol (iPGI) has been used for 12 years in our institution for the management of refractory PPHN despite the gaps in the literature to support this use. Read More

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http://dx.doi.org/10.1055/s-0038-1676483DOI Listing
December 2018
4 Reads

Undiagnosed cardiac deficits in non-small cell carcinoma patients in the candidate population for anti-cachexia clinical trials.

Support Care Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology, Division of Palliative Care Medicine, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.

Purpose: Currently, there is no approved therapy for cancer cachexia. According to European and American regulatory agencies, physical function improvements would be approvable co-primary endpoints of new anti-cachexia medications. As physical functioning is in part dependent on cardiac functioning, we aimed to explore the cardiac status of a group of patients meeting current criteria for inclusion in cachexia clinical trials. Read More

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http://dx.doi.org/10.1007/s00520-018-4561-yDOI Listing
December 2018

The long-term prognostic significance of sarcoidosis-associated pulmonary hypertension - A cohort study.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Background: Sarcoidosis is a multisystem, chronic, progressive, granulomatous disease. Sarcoidosis-associated pulmonary hypertension is a well described, but not common, complication of sarcoidosis. In small scale studies, it has been previously described as manifestation of advanced disease and was found to be associated increased morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183072
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http://dx.doi.org/10.1016/j.clim.2018.12.012DOI Listing
December 2018
2 Reads

Initial combination therapy with ambrisentan + tadalafil on pulmonary arterial hypertension‒related hospitalization in the AMBITION trial.

J Heart Lung Transplant 2018 Nov 22. Epub 2018 Nov 22.

University of California at San Diego, La Jolla, California, USA.

Background: In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) vs pooled monotherapy. These results were primarily driven by a reduction in PAH-related hospitalization in the combination therapy group, although a significant effect was not observed in a post-hoc analysis of all-cause hospitalization.

Methods: The effect of initial combination therapy with ambrisentan and tadalafil in AMBITION was further explored to study PAH-related hospitalization, which was not reported in the primary publication. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.006DOI Listing
November 2018
1 Read

[Prevalence and risk factors of sub-renal abdominal aortic aneurysm in an Algerian population aged over 60].

J Med Vasc 2018 Dec 26;43(6):361-368. Epub 2018 Oct 26.

Service de médecine interne, CHU Beni-Messous, Alger, Algérie.

Introduction: The prevalence of abdominal aortic aneurysm (AAA) in the general population in our country is not known, our aim was to evaluate it in patients over 60 years of age, to specify the risk factors and to evaluate the extension of aneurysmal disease and multisite subclinical atherosclerosis.

Methods: Descriptive, transversal, study collecting the data of a systematic ultrasound screening of sub-renal AAA in subjects receiving care in two Algerian hospital structures. Epidemiological data, AAA risk factors, cardiovascular disease risk factors (CVD RF) and the personal history (cardiovascular diseases, chronic obstructive pulmonary disease) and family history of AAA were collected during the screening. Read More

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http://dx.doi.org/10.1016/j.jdmv.2018.10.002DOI Listing
December 2018

Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling.

J Perinat Med 2018 Dec 7. Epub 2018 Dec 7.

Pediatrics, Division of Neonatology, New York University Medical Center, New York, NY, USA.

Background Earlier initiation of therapeutic hypothermia in term infants with hypoxic-ischemic encephalopathy has been shown to improve neurological outcomes. The objective of the study was to compare safety and effectiveness of servo-controlled active vs. passive cooling used during neonatal transport in achieving target core temperature. Read More

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http://dx.doi.org/10.1515/jpm-2018-0302DOI Listing
December 2018
2 Reads

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

Background: Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes.

Methods: We did two separate genome-wide association studies (GWAS) and a meta-analysis of pulmonary arterial hypertension. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30409-0DOI Listing
December 2018
11 Reads

Single Versus Bilateral Lung Transplantation for Idiopathic Pulmonary Fibrosis in the Lung Allocation Score Era.

J Surg Res 2019 Feb 5;234:84-95. Epub 2018 Oct 5.

Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease. Lung transplantation is the only therapy associated with prolonged survival. The ideal transplant procedure for IPF is unclear. Read More

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http://dx.doi.org/10.1016/j.jss.2018.08.054DOI Listing
February 2019
1 Read

A 44-Year-Old Woman With Sudden Breathlessness, Tightness in Chest, and Hypotension After Extubation in the Early Postoperative Period After Liver Transplantation.

Chest 2018 Dec;154(6):e177-e180

Critical Care Medicine Department, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubiran, Mexico City, Mexico. Electronic address:

Case Presentation: A 44-year-old woman with Child-Pugh class C cirrhosis due to primary biliary cirrhosis and mild portopulmonary syndrome received a liver transplant. Her basal catheterization showed a mean pulmonary arterial pressure (mPAP) of 28 mm Hg, pulmonary artery occlusion pressure (PAOP) of 8 mm Hg, pulmonary vascular resistance (PVR) of 307 dynes.s. Read More

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http://dx.doi.org/10.1016/j.chest.2018.07.004DOI Listing
December 2018

Cardiovascular risk factors differently affect the survival of patients undergoing manual or mechanical resuscitation.

BMC Cardiovasc Disord 2018 Dec 7;18(1):227. Epub 2018 Dec 7.

Department of Emergency Medicine, Faculty of Medicine, University of Debrecen, P.O. Box 19, Nagyerdei krt. 98, Debrecen, 4032, Hungary.

Background: Chest compression is a decisive element of cardio-pulmonary resuscitation (CPR). By applying a mechanical CPR device, compression interruptions can be minimised. We examined the efficiency of manual and device-assisted resuscitation as well as the effects of cardiovascular risk factors on the outcome of resuscitation. Read More

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http://dx.doi.org/10.1186/s12872-018-0962-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286513PMC
December 2018

Outcomes of minority patients with very severe hypertension (>220/>120 mmHg).

J Hypertens 2019 Feb;37(2):415-425

Clinical Pharmacology Research Unit (CPRU), Division of Clinical Pharmacology, Department of Medicine, Miller School of Medicine, University of Miami.

Objectives: Acute severe hypertension is a common problem among inner-city ethnic minority populations. Nevertheless, the effects of currently employed treatment regimens on blood pressure have not been determined in a clinical practice setting. We determined the SBP responses to acute antihypertensive drug protocols and the 2-year natural history of patients presenting with severe hypertension. Read More

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http://dx.doi.org/10.1097/HJH.0000000000001906DOI Listing
February 2019
2 Reads

Increased Risk of Benign Paroxysmal Positional Vertigo in Patients With Non-Apnea Sleep Disorders: A Nationwide, Population-Based Cohort Study.

J Clin Sleep Med 2018 Dec 15;14(12):2021-2029. Epub 2018 Dec 15.

School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Study Objectives: To investigate the association between non-apnea sleep disorders (NSD) and subsequent benign paroxysmal positional vertigo (BPPV) risk.

Methods: This retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database from 2000 to 2013. We established an NSD group (n = 24,624) and an age-, sex- and index year-matched comparison group (n = 98,496). Read More

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http://dx.doi.org/10.5664/jcsm.7528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287718PMC
December 2018
5 Reads
3.053 Impact Factor