8,747 results match your criteria Pulmonary Hypertension Imaging


Endogenous circulating testosterone and sex hormone-binding globulin levels and measures of myocardial structure and function: the Framingham Heart Study.

Andrology 2019 Feb 13. Epub 2019 Feb 13.

Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The relation between endogenous testosterone concentrations and myocardial mass and function remains incompletely understood.

Objectives: To determine the cross-sectional association between endogenous hormone levels with cardiac magnetic resonance measures of myocardial mass, structure, and function in community-dwelling men across a wide age range.

Methods: A total of 720 men from the Framingham Heart Study Offspring Cohort (age range 37-82, mean = 59. Read More

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http://dx.doi.org/10.1111/andr.12590DOI Listing
February 2019

A Painless Thoracic Aortic Dissection.

Eur J Case Rep Intern Med 2016 27;3(6):000443. Epub 2016 Jul 27.

Consultant Diabetes, Endocrinology and Acute Medicine, Ashford and St Peter's NHS Trust, Ashford, United Kingdom.

Thoracic aortic dissection (TAD) has a very high mortality rate and is often missed due to the atypical presentation of patients. We present a case of a man with chronic hypertension, atrial fibrillation (AF) (on regular warfarin) and a previous endovascular aneurysm repair (EVAR), who presented with dyspepsia and was incidentally found to have a ruptured distal thoracic aneurysm on imaging with no obvious clinical signs on examination, nor abnormalities on admission chest x-ray (CXR).

Learning Points: Typical symptoms and signs of thoracic aortic dissection (TAD), such as sudden onset of tearing pain and difference in blood pressure, can be absent in patients. Read More

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http://dx.doi.org/10.12890/2016_000443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346840PMC

Systemic Sclerosis and Serum Content of Transforming Growth Factor.

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Systemic sclerosis is a connective tissue disease characterized by tissue fibrosis leading to interstitial lung disease. Transforming growth factor-β (TGF-β) has been of interest as a potential diagnostic marker and also as a drug target in systemic sclerosis. The aim of this study was to assess the serum content of TGF-β1 in patients with systemic sclerosis and to assess its potential role in tissue fibrosis. Read More

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http://link.springer.com/10.1007/5584_2019_341
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http://dx.doi.org/10.1007/5584_2019_341DOI Listing
February 2019
1 Read

Pathophysiology of right ventricular failure in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension: a pictorial essay for the interventional radiologist.

Insights Imaging 2019 Feb 13;10(1):18. Epub 2019 Feb 13.

Radiology Department, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.

Pulmonary embolus (PE) is the third most common cause of cardiovascular death with more than 600,000 cases occurring in the USA per year. About 45% of patients with acute PE will have acute right ventricular failure, and up to 3.8% of patients will develop chronic thromboembolic pulmonary hypertension (CTEPH) with progressive, severe, chronic heart failure. Read More

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http://dx.doi.org/10.1186/s13244-019-0695-9DOI Listing
February 2019

A 32-Year-Old Woman with Relapsing Pneumonia.

Eur J Case Rep Intern Med 2018 28;5(8):000854. Epub 2018 Aug 28.

Pneumology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.

Introduction: Isolated right pulmonary artery agenesis in an adult patient is an extremely rare condition that requires a high level of suspicion to make the diagnosis.

Case Description: A 32-year-old woman presented to the emergency room with a 4-month history of recurrent respiratory infections. Chest radiography and computerized tomography (CT) revealed alveolar opacities on the medium and inferior right lobes. Read More

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http://dx.doi.org/10.12890/2018_000854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346833PMC

Early Right Ventricular Dysfunction in Highly Selected (Totally Free from Cardiovascular Risk Factors and Other Comorbidities) Human Immunodeficiency Virus Patients: A Pilot Study with Advanced Echocardiography.

J Cardiovasc Echogr 2018 Oct-Dec;28(4):228-232

Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy.

Objective: Human immunodeficiency virus (HIV) infection may also be associated with cardiac dysfunction, thus negatively affecting patients' morbidity and mortality. This preliminary study aimed at evaluating whether bi-and three-dimensional (3D) strain echocardiographic facilities were able to identify alterations in the right ventricular (RV) function in highly selected - because free from cardiovascular risk factors and other comorbidities - HIV patients.

Materials And Methods: Eight of these specific HIV patients (age: 32. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_43_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341850PMC
February 2019

Computed Tomography Appearance of Uncorrected Congenital Heart Disease in Adults.

J Thorac Imaging 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiology, University Hospital, Rutgers New Jersey Medical School, Newark, NJ.

The incidence of congenital heart disease (CHD) is about 4 to 10 per 1000 live births. While severe forms of CHD are usually diagnosed in infancy or childhood, milder and more survivable CHD may first manifest in the adult or may be discovered incidentally on imaging studies performed for other reasons. It is important to identify CHD in adults to implement appropriate treatment and prevent complications such as progression of pulmonary hypertension and development of heart failure. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000397DOI Listing
February 2019

Comprehensive Noninvasive Evaluation of Right Ventricle-Pulmonary Circulation Axis in Pediatric Patients with Pulmonary Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 9;21(1). Epub 2019 Feb 9.

Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO, 80045, USA.

Purpose Of Review: The purpose of this review is to detail the advanced echocardiographic studies that evaluated outcomes in pediatric PH using these advanced imaging techniques: (1) right heart size and function (using 2D and 3D echocardiography), (2) myocardial mechanics, and (3) right ventricular (RV) to pulmonary arterial coupling.

Recent Findings: Advanced echocardiographic imaging tools in pediatric PH include RV/left ventricular ratio, 3D echocardiographic assessment of RV volumes and ejection fraction, right atrial and RV strain, and RV-pulmonary arterial coupling ratio that allow for evaluation of clinical outcomes in this patient population. The right atrial to RV axis provides insights to RV diastolic function that has been poorly understood in pediatrics. Read More

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http://dx.doi.org/10.1007/s11936-019-0710-yDOI Listing
February 2019

Impacts of non-recovery of trastuzumab-induced cardiomyopathy on clinical outcomes in patients with breast cancer.

Clin Res Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, South Korea.

Objectives: The impacts of non-recovery of trastuzumab-induced left ventricular dysfunction (LVD) on clinical outcomes in breast cancer have been poorly studied. We investigated the predictors of LV-functional non-recovery and its impacts on clinical outcomes in breast cancer patients with trastuzumab-induced LVD.

Methods And Results: A total of 243 patients with trastuzumab-induced LVD were divided into the recovered LVD group (n = 195) and non-recovered LVD group (n = 48). Read More

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http://dx.doi.org/10.1007/s00392-019-01417-xDOI Listing
February 2019
4.560 Impact Factor

Exercise cardiovascular magnetic resonance imaging allows differentiation of low-risk pulmonary arterial hypertension.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

Background: Patients with pulmonary arterial hypertension (PAH) have a decreased ability to compensate for demands on increased cardiac output, such as during exercise. In this study we aimed to differentiate cardiac exercise responses in patients with PAH, stratified according to known measurements of disease severity.

Methods: Right and left ventricular end-diastolic volume and end-systolic volume, stroke volume (SV), and cardiac output were measured in 20 patients with PAH and a lower risk of mortality with 6-month intervals using cardiovascular magnetic resonance (CMR) imaging during rest and during ergometer exercise (totaling 44 scans). Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1305DOI Listing
January 2019
1 Read

Galectin-3 is Expressed in Vascular Smooth Muscle Cells and Promotes Pulmonary Hypertension through changes in Proliferation, Apoptosis and Fibrosis.

Am J Physiol Lung Cell Mol Physiol 2019 Feb 6. Epub 2019 Feb 6.

Augusta University, United States.

A defining characteristic of Pulmonary Hypertension (PH) is the extensive remodeling of pulmonary arteries (PA) that results in progressive increases in vascular resistance and stiffness and eventual failure of the right ventricle. There is no cure for PH and identification of novel molecular mechanisms that underlie increased proliferation, reduced apoptosis and excessive extracellular matrix production in pulmonary artery smooth muscle cells (PASMC) is a vital objective. Galectin-3 (Gal-3) is a chimeric lectin and potent driver of many aspects of fibrosis, but its role in regulating PASMC behavior in PH remains poorly understood. Read More

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http://dx.doi.org/10.1152/ajplung.00186.2018DOI Listing
February 2019
2 Reads

Acute Iloprost Inhalation Improves Right Ventricle Function in Pulmonary Artery Hypertension: A Cardiac Magnetic Resonance Study.

Front Pharmacol 2018 21;9:1550. Epub 2019 Jan 21.

Tianjin Medical University General Hospital, Tianjin, China.

Right ventricle (RV) function is among the most important prognostic factors for pulmonary arterial hypertension (PAH) patients. Inhaled iloprost, an inhaled member of the prostacyclin family, is effective for the treatment of severe PAH and acute RV failure. However, the acute effects of iloprost on RV physiology have not been thoroughly explored in the past. Read More

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http://dx.doi.org/10.3389/fphar.2018.01550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348276PMC
January 2019
1 Read

Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy.

ACS Nano 2019 Feb 8. Epub 2019 Feb 8.

School of Biomedical Sciences, Faculty of Biological Sciences , University of Leeds , Leeds LS2 9JT , United Kingdom.

Nanodomains are intracellular foci which transduce signals between major cellular compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) calcium channel, is tightly clustered within these nanodomains. Super-resolution microscopy has previously been used to visualize RyR clusters near the cell surface. Read More

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http://dx.doi.org/10.1021/acsnano.8b08742DOI Listing
February 2019
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Computed tomography-measured pulmonary artery to aorta ratio and EUTOS score for detecting dasatinib-induced pulmonary arterial hypertension.

Int J Cardiovasc Imaging 2019 Feb 4. Epub 2019 Feb 4.

Division of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan.

Background: Periodic echo-based screening to detect early stages of a rare complication of dasatinib, pulmonary arterial hypertension (PAH), is inefficient and weakens the potential benefit of dasatinib as a potent drug for chronic myelogenous leukemia (CML). This study aimed to identify the predisposing factors of DASA-PAH to stratify high-risk patients for dasatinib-induced PAH (DASA-PAH).

Methods: Sixty consecutive adult patients who received dasatinib were enrolled in this case-control study. Read More

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http://dx.doi.org/10.1007/s10554-019-01548-2DOI Listing
February 2019
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A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.

Br J Pharmacol 2019 Feb 2. Epub 2019 Feb 2.

Experimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.

Background And Purpose: Apelin is an endogenous vasodilatory and inotropic peptide that is down-regulated in human pulmonary arterial hypertension, however, the density of the apelin receptor is not significantly attenuated. We hypothesised that a G protein-biased apelin analogue MM07, which is more stable than the endogenous apelin peptide, may be beneficial in this condition with the advantage of reduced β-arrestin mediated receptor internalisation with chronic use.

Experimental Approach: Male Sprague-Dawley rats received either monocrotaline to induce pulmonary arterial hypertension or saline and then daily intraperitoneal injections of either MM07 or saline for 21 days. Read More

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http://doi.wiley.com/10.1111/bph.14603
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http://dx.doi.org/10.1111/bph.14603DOI Listing
February 2019
3 Reads

Perspectives of using pulmonary arterial stiffness indicators to evaluate the prognosis  of patients with pulmonary arterial hypertension.

Ter Arkh 2018 Feb;90(1):86-92

Almazov National Medical Research Centre.

Aim: The aim of the study was to characterize the mechanical properties of the pulmonary arterial wall (PA) in patients with pulmonary arterial hypertension (PAH) using magnetic resonance imaging (MRI) of the heart, and to determine their diagnostic and prognostic value.

Materials And Methods: 57 patients with PAH were examined. The diagnosis of PAH was verified according to the recommendations of the ERS/ESC from 2015. Read More

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http://dx.doi.org/10.26442/terarkh201890186-92DOI Listing
February 2018

Normal values of the pulmonary artery acceleration time (PAAT) and the right ventricular ejection time (RVET) in children and adolescents and the impact of the PAAT/RVET-index in the assessment of pulmonary hypertension.

Int J Cardiovasc Imaging 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatric Cardiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuernberg, Erlangen, Germany.

New echocardiographic modalities including pulmonary artery acceleration time (PAAT) and right ventricular ejection time (RVET) are evolving to facilitate an early non-invasive diagnosis for pulmonary hypertension (PH) in adults. In children, PAAT depends on age, body surface area (BSA) and heart rate (HR) and is used to predict PH. Normal values of RVET and their role to predict PH in children are still missing. Read More

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http://dx.doi.org/10.1007/s10554-019-01540-wDOI Listing
January 2019

A Large Animal Model of Right Ventricular Failure due to Chronic Thromboembolic Pulmonary Hypertension: A Focus on Function.

Front Cardiovasc Med 2018 9;5:189. Epub 2019 Jan 9.

Department of Biomedical Engineering, Univeristy of Wisconsin-Madison, Madison, WI, United States.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a debilitating disease that progresses to right ventricular (RV) failure and death if left untreated. Little is known regarding the progression of RV failure in this disease, greatly limiting effective prognoses, and therapeutic interventions. Large animal models enable the use of clinical techniques and technologies to assess progression and diagnose failure, but the existing large animal models of CTEPH have not been shown to replicate the functional consequences of the RV, i. Read More

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http://dx.doi.org/10.3389/fcvm.2018.00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333696PMC
January 2019
1 Read

Isolated partial right lower lobe pulmonary venous drainage into the right atrium as a cause of pulmonary hypertension in a middle-aged woman.

J Clin Ultrasound 2019 Jan 25. Epub 2019 Jan 25.

Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Partial anomalous pulmonary venous connection is a rare congenital disease characterized by drainage of one or several pulmonary veins into the systemic venous system. It is extremely rare as an isolated anomaly. We report the case of a middle-aged woman with isolated drainage of an enormously enlarged right lower pulmonary vein into the right atrium with significant left-to-right shunt, severe right ventricular enlargement, and pulmonary hypertension. Read More

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http://dx.doi.org/10.1002/jcu.22691DOI Listing
January 2019

Automatic 3D bi-ventricular segmentation of cardiac images by a shape-refined multi-task deep learning approach.

IEEE Trans Med Imaging 2019 Jan 23. Epub 2019 Jan 23.

Deep learning approaches have achieved state-of-the-art performance in cardiac magnetic resonance (CMR) image segmentation. However, most approaches have focused on learning image intensity features for segmentation, whereas the incorporation of anatomical shape priors has received less attention. In this paper, we combine a multi-task deep learning approach with atlas propagation to develop a shape-refined bi-ventricular segmentation pipeline for short-axis CMR volumetric images. Read More

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http://dx.doi.org/10.1109/TMI.2019.2894322DOI Listing
January 2019
1 Read

Nicotine dependence as an independent risk factor for atherosclerosis in the National Lung Screening Trial.

BMC Public Health 2019 Jan 22;19(1):103. Epub 2019 Jan 22.

Penn State College of Medicine, Department of Public Health Sciences, Pennsylvania State University, MC CH69, 500 University Drive, P.O. Box 850, Hershey, PA, 17033, USA.

Background: Atherosclerosis and COPD are systemic inflammatory diseases that share common risk factors including cigarette smoking. A high level of nicotine dependence is emerging as a recently identified risk factor for pulmonary impairment, chronic obstructive pulmonary disease and tobacco-related cancers. We hypothesized that nicotine dependence is associated with the risk of atherosclerosis in long-term cigarette smokers. Read More

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http://dx.doi.org/10.1186/s12889-019-6419-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343324PMC
January 2019
3 Reads

Echocardiographic evaluation of left ventricular filling pressures in patients with pulmonary hypertension.

Int J Cardiovasc Imaging 2019 Jan 21. Epub 2019 Jan 21.

Department of Internal Medicine II, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Echocardiographic assessment of diastolic dysfunction depends on surrogate parameters. In recent years, guideline committees attempted to combine these parameters to diagnostic flowcharts allowing for correct classification of left ventricular filling pressures (LVFP). The value of these diagnostic tools is limited if the applied surrogate parameters are elevated due to other reasons as is the case with maximal tricuspid regurgitation velocity. Read More

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http://link.springer.com/10.1007/s10554-019-01528-6
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http://dx.doi.org/10.1007/s10554-019-01528-6DOI Listing
January 2019
3 Reads

Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis.

Case Rep Endocrinol 2018 19;2018:9564737. Epub 2018 Dec 19.

Pediatric Endocrinology Unit, Department of Pediatrics, Centro Materno Infantil do Norte-Centro Hospitalar Universitário do Porto, Oporto, Portugal.

Fetal goiter is a rare disorder not expected to be found during a healthy woman's pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks' gestation of a healthy primigravida. Read More

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http://dx.doi.org/10.1155/2018/9564737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313984PMC
December 2018
2 Reads

A 26-year-old man with severe right ventricular hypertrophy.

Heart 2019 Jan 19. Epub 2019 Jan 19.

Division of Pediatric Cardiology, Duke University, Durham, North Carolina, USA.

Question: The aetiology of his cMRI findings is most likely:Pulmonary hypertension from chronic left-to-right shunting.Infundibular obstruction from anterior deviation of the conal septum.Subinfundibular obstruction from hypertrophied muscle bundles. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314123DOI Listing
January 2019
1 Read

CT-measured pulmonary artery diameter as an independent predictor of pulmonary hypertension in cystic fibrosis.

Pol J Radiol 2018 23;83:e401-e406. Epub 2018 Aug 23.

Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: The role of computed tomography (CT) scan, as a promising prognostic imaging modality in cystic fibrosis (CF), has been widely investigated, focusing on parenchymal abnormalities. The aim of the present study was to evaluate the diagnostic performance of thoracic vascular parameters on CT to detect pulmonary hypertension (PH).

Material And Methods: CF patients who contemporaneously underwent CT and echocardiography were retrospectively enrolled. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.79204
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http://dx.doi.org/10.5114/pjr.2018.79204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334125PMC
August 2018
7 Reads

Rate of instrumentation changes on postoperative and follow-up radiographs after primary complex spinal fusion (five or more levels) for adult deformity correction.

J Neurosurg Spine 2019 Jan 11:1-6. Epub 2019 Jan 11.

2Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.

OBJECTIVEIn the United States, healthcare expenditures have been soaring at a concerning rate. There has been an excessive use of postoperative radiographs after spine surgery and this has been a target for hospitals to reduce unnecessary costs. However, there are only limited data identifying the rate of instrumentation changes on radiographs after complex spine surgery involving ≥ 5-level fusions. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18686DOI Listing
January 2019
5 Reads

Evolution of hemodynamic forces in the pulmonary tree with progressively worsening pulmonary arterial hypertension in pediatric patients.

Biomech Model Mechanobiol 2019 Jan 12. Epub 2019 Jan 12.

Departments of Pediatrics and Bioengineering, Stanford University, Stanford, CA, USA.

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling resulting in right ventricular (RV) dysfunction and ultimately RV failure. Mechanical stimuli acting on the vessel walls of the full pulmonary tree have not previously been comprehensively characterized. The goal of this study is to characterize wall shear stress (WSS) and strain in pediatric PAH patients at different stages of disease severity using computational patient-specific modeling. Read More

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http://dx.doi.org/10.1007/s10237-018-01114-0DOI Listing
January 2019
2 Reads

Effect of pulmonary artery denervation in postcapillary pulmonary hypertension: results of a randomized controlled translational study.

Basic Res Cardiol 2019 Jan 11;114(2). Epub 2019 Jan 11.

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

There is scarce evidence for pulmonary artery denervation (PADN) as a potential treatment for chronic postcapillary pulmonary hypertension (PH). We aimed to perform a proof-of-concept of PADN in a translational model of chronic PH. Nineteen pigs with chronic postcapillary PH (secondary to pulmonary vein banding) were randomized to surgical-PADN (using bipolar radiofrequency clamps) or sham procedure. Read More

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http://dx.doi.org/10.1007/s00395-018-0714-xDOI Listing
January 2019
3 Reads

Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes.

Pediatr Radiol 2019 Jan 11. Epub 2019 Jan 11.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: The presence of a hernia sac in congenital diaphragmatic hernia (CDH) has been reported to be associated with higher lung volumes and better postnatal outcomes.

Objective: To compare prenatal imaging (ultrasound and MRI) prognostic measurements and postnatal outcomes of CDH with and without hernia sac.

Materials And Methods: We performed database searches from January 2008 to March 2017 for surgically proven cases of CDH with and without hernia sac. Read More

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http://dx.doi.org/10.1007/s00247-018-04334-9DOI Listing
January 2019
1 Read

Right Ventricular-Arterial Coupling Ratio Derived From 3-Dimensional Echocardiography Predicts Outcomes in Pediatric Pulmonary Hypertension.

Circ Cardiovasc Imaging 2019 Dec;12(1):e008176

Department of Pediatrics, Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (P.-N.J., M.S., D.D.I.).

Background: Right ventricular (RV) function is an important determinant of outcomes in pulmonary hypertension (PH). RV-arterial coupling ratio using stroke volume (SV) to end-systolic volume (ESV) has been shown to be an independent predictor of outcome in adults with PH. SV/ESV has not been used in pediatrics to predict outcomes. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336104PMC
December 2019

Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.

Arterioscler Thromb Vasc Biol 2019 Jan 10:ATVBAHA118312280. Epub 2019 Jan 10.

From the Department of Pathophysiology, School of Basic Medicine (L.Z., R.X., X.Z., Y.Lang, F.L., Z.Y., S.L., Q.H.).

Objective- This study aims to determine whether and how the enriched metabolites of endothelial extracellular vesicles (eEVs) are critical for cigarette smoke-induced direct injury of endothelial cells and the development of pulmonary hypertension, rarely explored in contrast to long-investigated mechanisms secondary to chronic hypoxemia. Approach and Results- Metabonomic screen of eEVs from cigarette-smoking human subjects reveals prominent elevation of spermine-a polyamine metabolite with potent agonist activity for the extracellular CaSR (calcium-sensing receptor). CaSR inhibition with the negative allosteric modulator Calhex231 or CaSR knockdown attenuates cigarette smoke-induced pulmonary hypertension in rats without emphysematous changes in lungs or chronic hypoxemia. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312280DOI Listing
January 2019
8 Reads

Visceral artery anomalies in patients with Alagille syndrome.

Pediatr Transplant 2019 Jan 9:e13352. Epub 2019 Jan 9.

Department of Transplant Surgery, Jichi Medical University, Shimotsuke City, Tochigi, Japan.

Background: Intracranial and pulmonary vascular anomalies are well-known complications and causes of mortality in AGS; however, visceral artery anomalies are less commonly recognized. Herein, we present a retrospective analysis of our experience with pediatric LDLT that focuses on the current problems with and treatments for visceral artery anomalies in AGS after LDLT.

Methods: Between May 2001 and December 2017, 294 LDLTs were performed for 285 pediatric recipients. Read More

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http://dx.doi.org/10.1111/petr.13352DOI Listing
January 2019
3 Reads

Prevalence, determinants, and prognostic significance of exercise-induced pulmonary hypertension in patients with hypertrophic cardiomyopathy.

Int J Cardiovasc Imaging 2019 Jan 8. Epub 2019 Jan 8.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.

Exercise-induced pulmonary hypertension (EIPH) is associated with worse outcomes in patients with heart failure or valvular heart disease. However, little is known regarding the implications of EIPH in hypertrophic cardiomyopathy (HCM) patients. We retrospectively reviewed data of consecutive HCM patients who underwent clinically indicated exercise echocardiography using a semi-supine bicycle ergometer at our hospital. Read More

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http://link.springer.com/10.1007/s10554-018-01522-4
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http://dx.doi.org/10.1007/s10554-018-01522-4DOI Listing
January 2019
3 Reads

Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies.

Pulm Circ 2019 Jan-Mar;9(1):2045894018819781. Epub 2018 Dec 3.

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM), end-diastolic volume (RVEDV), end-systolic volume (RVESV), stroke volume (RVSV), and ejection fraction (RVEF) were assessed using cardiac magnetic resonance imaging (MRI) scans of 4204 participants without clinical cardiovascular disease at the baseline examination; retinal photography was obtained at the second examination. Read More

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http://dx.doi.org/10.1177/2045894018819781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304712PMC
December 2018
5 Reads

Perfusion Scintigraphy in Diagnosis and Management of Thromboembolic Pulmonary Hypertension.

Radiographics 2019 Jan-Feb;39(1):169-185

From the Department of Radiology, Division of Nuclear Medicine (F.M., C.K.H.); and Division of Pulmonary, Critical Care, and Sleep Medicine (T.A.M.), University of California, San Diego, San Diego, Calif.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication of acute pulmonary embolism (PE). Because the treatment of CTEPH is markedly different from that of other types of pulmonary hypertension, lung ventilation-perfusion (V/Q) scintigraphy is recommended for the workup of patients with unexplained pulmonary hypertension. Lung V/Q scintigraphy is superior to CT pulmonary angiography for detecting CTEPH. Read More

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http://dx.doi.org/10.1148/rg.2019180074DOI Listing
January 2019
4 Reads

Reserve of Right Ventricular-Arterial Coupling in the Setting of Chronic Overload.

Circ Heart Fail 2019 Jan;12(1):e005512

Department of Internal Medicine (K.T., A.D., J.A., H.A.G., W.S., N.S., J.W., H.G., M.J.R.).

Background: Right ventricular (RV) maladaptation and failure determine outcome in pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial coupling) is defined by a ratio of end-systolic to arterial elastances (Ees/Ea). How RV-pulmonary arterial coupling relates to pulmonary hypertension severity and onset of RV failure (defined by excessive volume increase and ejection fraction [EF] decrease) is not exactly known. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005512DOI Listing
January 2019
2 Reads

Assessment of Right Ventricular Function in Pulmonary Hypertension with Multimodality Imaging.

J Cardiovasc Imaging 2018 Dec 21;26(4):189-200. Epub 2018 Dec 21.

Department of Radiology, Soonchunhyang University Hospital, Bucheon, Korea.

Pulmonary hypertension (PH) is defined as resting mean pulmonary artery pressure ≥ 25 mmHg and is caused by multiple etiologies including heart, lung or other systemic diseases. Evaluation of right ventricular (RV) function in PH is very important to plan treatment and determine prognosis. However, quantification of volume and function of the RV remains difficult due to complicated RV geometry. Read More

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http://dx.doi.org/10.4250/jcvi.2018.26.e28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310752PMC
December 2018
1 Read

Decreased biventricular longitudinal strain in patients with systemic sclerosis is mainly caused by pulmonary hypertension and not by systemic sclerosis per se.

Clin Physiol Funct Imaging 2018 Dec 31. Epub 2018 Dec 31.

Department of Clinical Sciences Lund, Clinical Physiology, Skåne University Hospital, Lund University, Lund, Sweden.

Purpose: Patients with pulmonary arterial hypertension (PAH) due to systemic sclerosis (SSc) have high mortality. Left ventricular (LV) peak global longitudinal strain (GLS) is decreased in SSc. It is unknown whether low GLS is due to SSc or PAH. Read More

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http://doi.wiley.com/10.1111/cpf.12561
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http://dx.doi.org/10.1111/cpf.12561DOI Listing
December 2018
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The Right Ventricle During Selective Lung Ventilation for Thoracic Surgery.

J Cardiothorac Vasc Anesth 2018 Nov 22. Epub 2018 Nov 22.

University Hospitals Birmingham National Health Service Foundation Trust, Department of Critical Care Medicine, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, Centre of Translational Inflammation Research, University of Birmingham, Birmingham, UK.

The right ventricle (RV) has been an area of evolving interest after decades of being ignored and considered less important than the left ventricle. Right ventricular dysfunction/failure is an independent predictor of mortality and morbidity in cardiac surgery; however, very little is known about the incidence or impact of RV dysfunction/failure in thoracic surgery. The pathophysiology of RV dysfunction/failure has been studied in the context of acute respiratory distress syndrome (ARDS), cardiac surgery, pulmonary hypertension, and left ventricular failure, but limited data exist in literature addressing the issue of RV dysfunction/failure in the context of thoracic surgery and one-lung ventilation (OLV). Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.030DOI Listing
November 2018
2 Reads

Immediate and late clinical outcomes of balloon mitral valvotomy based on immediate postballoon mitral valvotomy mitral valve area & percentage gain in mitral valve area-A tertiary centre study.

Indian Heart J 2018 Dec 6;70 Suppl 3:S338-S346. Epub 2018 Oct 6.

Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, 695011, India. Electronic address:

Aim: The aim of the study was to compare the immediate and late clinical outcomes of balloon mitral valvotomy (BMV), based on the immediate post-BMV valve area and percentage gain in mitral valve area (MVA).

Methods: Clinical data of 818 consecutive patients who underwent BMV in our institute from 2000 to 2008 were analyzed retrospectively. They were categorized into three groups based on the postprocedural MVA and percentage gain in valve area-(1) 50% gain with final MVA <1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00194832183037
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http://dx.doi.org/10.1016/j.ihj.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309712PMC
December 2018
5 Reads

Reliability of Doppler echocardiography in the assessment of high pulmonary vascular resistance in patients with severe pulmonary arterial hypertension.

Indian Heart J 2018 Dec 2;70 Suppl 3:S241-S244. Epub 2018 Nov 2.

Department of Cardiology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, 500082 India. Electronic address:

Background: The objective is to assess whether the squaring of tricuspid regurgitation velocity (TRV) gives an improved estimate of pulmonary vascular resistance (PVR) or is equivalent to the ratio of TRV and time velocity integral of right ventricular outflow tract (TVI) (TRV/TVI) for assessing PVR in patients with high PVR values.

Methods: Thirty patients predicted to have PVR >6 WU by Doppler were included in the present study. TRV and TVI were measured by echo Doppler. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00194832183064
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http://dx.doi.org/10.1016/j.ihj.2018.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310071PMC
December 2018
5 Reads

Whole-exome sequencing reveals a novel mutation of MT-ND5 gene in a mitochondrial cardiomyopathy pedigree: Patients who show biventricular hypertrophy, hyperlactacidemia, pulmonary hypertension, and decreased exercise tolerance.

Anatol J Cardiol 2019 Jan;21(1):18-24

Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Disease, Shanghai Institute of Medical Imaging; Shanghai-China.

Objective: The aim of the present study was to determine whether pathogenic mutations were present in families with mitochondrial cardiomyopathy that presented during adolescence.

Methods: The proband was a 21-year-old man who presented clinically with palpitations, chest tightness, pulmonary hypertension, and limited exercise tolerance. Cardiac magnetic resonance imaging studies showed biventricular cardiac hypertrophy. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2018.53258DOI Listing
January 2019
5 Reads

ERS statement on exercise training and rehabilitation in patients with severe chronic pulmonary hypertension.

Eur Respir J 2018 Dec 21. Epub 2018 Dec 21.

Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom.

Objectives of this ERS Task Force were to summarise current studies, to develop strategies for future research and to increase availability and awareness of exercise training for pulmonary hypertension (PH) patients.An evidence-based approach with clinical expertise of the Task Force members, based on both literature search and face-to-face meetings was conducted. The statement summarises current knowledge and open questions regarding clinical effects of exercise training in PH, training modalities, implementation strategies and pathophysiologic mechanisms. Read More

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00332
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http://dx.doi.org/10.1183/13993003.00332-2018DOI Listing
December 2018
6 Reads

MRI assessment of aortic flow in patients with pulmonary arterial hypertension in response to exercise.

BMC Med Imaging 2018 Dec 22;18(1):55. Epub 2018 Dec 22.

Department of Medical Physics, University of Wisconsin, 1111 Highland Avenue, Room 1005, Madison, WI, 53705, USA.

Background: While primarily a right heart disease, pulmonary arterial hypertension (PAH) can impact left heart function and aortic flow through a shifted interventricular septum from right ventricular pressure overload and reduced left ventricular preload, among other mechanisms. In this study, we used phase contrast (PC) MRI and a modest exercise challenge to examine the effects of PAH on systemic circulation. While exercise challenges are typically performed with ultrasound in the clinic, MRI exercise studies allow for more reproducible image alignment, more accurate flow quantification, and improved tissue contrast. Read More

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https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12880-018-0298-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303959PMC
December 2018
8 Reads

Chronic thromboembolic pulmonary hypertension.

Swiss Med Wkly 2018 12 21;148:w14702. Epub 2018 Dec 21.

CTEPH Programme University Hospital Zurich, Switzerland.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a potentially fatal disease, which may occur as a rare complication after acute pulmonary embolism, although the exact epidemiology of CTEPH is unknown. The mechanisms involved in nonresolution of thrombotic material and scarring of large and/or small pulmonary arteries are unknown; some risk factors have been identified. To date, CTEPH is still underdiagnosed and undertreated. Read More

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http://dx.doi.org/10.4414/smw.2018.14702DOI Listing
December 2018
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[Value of four-dimensional echocardiography combined with speckle tracking technique on the assessment of right heart function and prognosis in patients with pulmonary arterial hypertension].

Zhonghua Xin Xue Guan Bing Za Zhi 2018 Dec;46(12):965-971

Department of Cardiology, Renji Hospital (South), Shanghai Jiaotong University School ofMedicine, Shanghai 201112, China.

To investigate the value of four-dimensional echocardiography combined with speckle tracking technique on the assessment of right heart function and prognosis in patients with pulmonary arterial hypertension (PAH). In this prospective study, 51 patients with PAH diagnosed by right heart catheterization in east hospital and south hospital of Renji hospital affiliated to school of medicine of Shanghai Jiaotong University from September 2015 to July 2017 were enrolled as PAH group from July to November 2017. Meanwhile, 26 healthy volunteers with age and sex matched with pulmonary hypertension patients were recruited as control group. Read More

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http://doi.med.wanfangdata.com.cn/10.3760/cma.j.issn.0253-37
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http://dx.doi.org/10.3760/cma.j.issn.0253-3758.2018.12.007DOI Listing
December 2018
2 Reads

Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension.

Circ Cardiovasc Imaging 2018 Nov;11(11):e006984

Division of Cardiology, Department of Medicine (F.A., A.M., E.J.V., P.S.D., Z.S., S.R.), Duke University Medical Center, Durham, NC.

Background Although right atrial (RA) enlargement is an established marker for adverse outcomes, the prognostic importance of RA dysfunction independent of RA size in pulmonary arterial hypertension is not known. Methods and Results Study subjects with pulmonary arterial hypertension were prospectively enrolled from 2010 to 2014. RA function was measured using RA speckle-tracking longitudinal strain and strain rate (SR) during each phase of the cardiac cycle: (1) RA reservoir (peak longitudinal strain, peak systolic SR), (2) RA conduit (peak early diastolic SR), and (3) RA active contraction (peak active contraction strain, peak contraction SR). Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.117.006984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309911PMC
November 2018
1 Read

Carotid Flow Augmentation, Arterial Aging, and Cerebral White Matter Hyperintensities.

Arterioscler Thromb Vasc Biol 2018 Dec;38(12):2843-2853

Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (J.H., S.I.).

Objective- Aortic stiffness and pressure wave reflection are associated with age-related cerebral microvascular disease, but the underlying mechanism remains obscure. We hypothesized that cerebral (carotid) flow alterations potentially mediate these associations. Approach and Results- Doppler waveforms were recorded in 286 patients with hypertension to measure the carotid flow augmentation index (FAIx) as the late/early-systolic velocity amplitude ratio. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311873DOI Listing
December 2018
1 Read