10,614 results match your criteria Pulmonary Hypertension Imaging


Study design of a randomised, placebo-controlled trial of nintedanib in children and adolescents with fibrosing interstitial lung disease.

ERJ Open Res 2021 Apr 21;7(2). Epub 2021 Jun 21.

Division of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Childhood interstitial lung disease (chILD) comprises >200 rare respiratory disorders, with no currently approved therapies and variable prognosis. Nintedanib reduces the rate of forced vital capacity (FVC) decline in adults with progressive fibrosing interstitial lung diseases (ILDs). We present the design of a multicentre, prospective, double-blind, randomised, placebo-controlled clinical trial of nintedanib in patients with fibrosing chILD (1199-0337 or InPedILD; ClinicalTrials. Read More

View Article and Full-Text PDF

Back to basics: a rare and aggressive case of endocarditis.

Oxf Med Case Reports 2021 Jun 18;2021(6):omab043. Epub 2021 Jun 18.

Department of Cardiology, Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton & Harefield NHS Trust, National Heart & Lung Institute, Imperial College, London, UK.

We present the case of a 25-year-old with a history of bicuspid aortic valve and ascending aortopathy who was successfully treated for infective endocarditis (IE) due to . His clinical course was complicated by a large aortic root abscess not initially visualised on transthoracic echocardiography or computerised tomography. The cardinal feature of progressive prolongation of the PR interval on serial electrocardiograms was the only sign associated with clinical deterioration and was the trigger for rapid investigation and urgent management. Read More

View Article and Full-Text PDF

Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Down Regulation of sGC and Contributes to Exercise-Induced Pulmonary Hypertension in HFpEF.

Circulation 2021 Jun 23. Epub 2021 Jun 23.

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Many patients with heart failure with preserved ejection fraction (HFpEF) have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with HFpEF portend a poor prognosis; this phenotype is referred to as combined pre-and post-capillary PH (CpcPH). Therapeutic trials for EIPH and CpcPH have been disappointing, suggesting the need for strategies that target upstream mechanisms of disease. Read More

View Article and Full-Text PDF

A case of gadobenate dimeglumine-induced anaphylactic shock: a case report.

Ann Palliat Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Pharmacy, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

A 70-year-old man was admitted to our hospital due to "liver cirrhosis; grade 3 hypertension; pulmonary infection". On May 27, 2019, during upper abdomen plain and enhanced magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP), the patient experienced anaphylactic shock, manifested as sudden unconsciousness and lack of response, after intravenous administration of gadobenate dimeglumine (Multihance®). Gadobenate dimeglumine is a paramagnetic contrast used during diagnostic MRI. Read More

View Article and Full-Text PDF

Diverse Right Ventricular Remodeling Evaluated by MRI and Prognosis in Eisenmenger Syndrome With Different Shunt Locations.

J Magn Reson Imaging 2021 Jun 21. Epub 2021 Jun 21.

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR China.

Background: Congenital shunt location is related to Eisenmenger syndrome (ES) survival. Moreover, right ventricular (RV) remodeling is associated with poor survival in pulmonary hypertension.

Purpose: To investigate RV remodeling using comprehensive magnetic resonance imaging (MRI) techniques and identify its relationship with prognosis in ES subgroups classified by shunt location. Read More

View Article and Full-Text PDF

Current and new imaging techniques in risk stratification of asymptomatic severe aortic stenosis.

Acta Cardiol 2021 Jun 21:1-9. Epub 2021 Jun 21.

Cardiology Department, Abderrahmane Mami's Hospital, Ariana, Tunisia.

Aortic stenosis (AS) is one of the most common valvular diseases in clinical practice. The prevalence of calcified AS with moderate or severe stenosis exceeds 2% after 75 years. The optimal timing of intervention for asymptomatic severe AS is uncertain and controversial. Read More

View Article and Full-Text PDF

Accuracy of echocardiographic estimates of pulmonary artery pressures in pulmonary hypertension: insights from the KARUM hemodynamic database.

Int J Cardiovasc Imaging 2021 Jun 19. Epub 2021 Jun 19.

Department of Clinical Physiology, Surgical & Perioperative Sciences, Umeå University, Umeå, Sweden.

Accurate assessment of pulmonary artery (PA) pressures is integral to diagnosis, follow-up and therapy selection in pulmonary hypertension (PH). Despite wide utilization, the accuracy of echocardiography to estimate PA pressures has been debated. We aimed to evaluate echocardiographic accuracy to estimate right heart catheterization (RHC) based PA pressures in a large, dual-centre hemodynamic database. Read More

View Article and Full-Text PDF

The tailor-made treatment in a particular case of pulmonary hypertension in thalassaemia intermedia: a case report.

Eur Heart J Case Rep 2021 Jun 16;5(6):ytab193. Epub 2021 Jun 16.

Dyspnea Lab, Department Clinical Sciences and Community Health, University of Milan, Italy.

Background: Pulmonary hypertension (PH) is a haemodynamic condition, secondary to different causes. Thalassaemia may lead to PH of different origin and needs a comprehensive analysis to be correctly characterized and possibly treated.

Case Summary: We present a case study of a patient with a non-transfusion-dependent thalassaemia and a previous diagnosis of group 5 PH. Read More

View Article and Full-Text PDF

Evaluation of Diagnostic Accuracy and Radiation Exposure of Dual-Energy Computed Tomography (DECT) in the Course of Chronic Thromboembolic Pulmonary Hypertension (CTEPH).

Rofo 2021 Jun 17. Epub 2021 Jun 17.

Department of Diagnostic and Interventional Radiology, University Hospital Gießen, Justus Liebig University, Gießen, Germany.

Purpose:  The purpose of this study was to assess the diagnostic accuracy of computed tomography pulmonary angiogram (CTPA) including dual energy and reconstruction of iodine maps for diagnosing CTEPH. This method for detecting embolisms and perfusion failures was compared with V/Q-SPECT. An additional purpose was to compare the applied radiation dose of both techniques. Read More

View Article and Full-Text PDF

Comparison of dual-energy computer tomography and dynamic contrast-enhanced MRI for evaluating lung perfusion defects in chronic thromboembolic pulmonary hypertension.

PLoS One 2021 17;16(6):e0251740. Epub 2021 Jun 17.

Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.

Objectives: To evaluate the agreement in detecting pulmonary perfusion defects in patients with chronic thromboembolic pulmonary hypertension using dual-energy CT and dynamic contrast-enhanced MRI. Second, to compare both imaging modalities in monitoring lung perfusion changes in these patients after undergoing pulmonary endarterectomy.

Methods: 20 patients were examined with CT and MRI before and/or after pulmonary endarterectomy. Read More

View Article and Full-Text PDF

Postpulmonary embolism syndrome.

Curr Opin Pulm Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Pulmonary/Sleep and Critical Care Medicine, Walter Reed National Military Medical Center (WRNMMC), Bethesda, Maryland, USA.

Purpose Of Review: It is now recognized that more than half of patients with acute pulmonary embolism (APE) will have persistent symptoms beyond 3 months after their initial event. Persistent symptoms are referred to as post-PE syndrome, an umbrella term that covers a spectrum of patient complaints and underlying pathologies. Data published over the last 5 years have added significantly to our understanding of this syndrome and its management. Read More

View Article and Full-Text PDF

Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension.

Front Physiol 2021 28;12:641310. Epub 2021 May 28.

Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.

Pulmonary arterial hypertension (PAH) is a disease resulting in increased right ventricular (RV) afterload and RV remodeling. PAH results in altered RV structure and function at different scales from organ-level hemodynamics to tissue-level biomechanical properties, fiber-level architecture, and cardiomyocyte-level contractility. Biomechanical analysis of RV pathophysiology has drawn significant attention over the past years and recent work has found a close link between RV biomechanics and physiological function. Read More

View Article and Full-Text PDF

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.

Circulation 2021 Jun 11. Epub 2021 Jun 11.

Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Pulmonary hypertension (PH) is a common complication in patients with Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with mutations in the gene. While the loss of alveolar microvasculature causes PH in ACDMPV patients, it is unknown whether increasing neonatal lung angiogenesis could prevent PH and right ventricular (RV) hypertrophy. We used echocardiography, RV catheterization, immunostaining and biochemical methods to examine lung and heart remodeling and RV output in mice carrying the mutation (identified in ACDMPV patients). Read More

View Article and Full-Text PDF

Current advances in cardiac magnetic resonance imaging in systemic sclerosis.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3718-3736

Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Systemic sclerosis (SSc) is a systemic autoimmune disorder characterized by inflammation, fibroproliferative vasculopathy, and progressive fibrosis. Cardiac involvement is common in SSc and may affect the myocardium, pericardium, heart valves, conduction system, as well as coronary arteries. However, it remains asymptomatic for a long time, which leads to delayed diagnosis and poor prognosis. Read More

View Article and Full-Text PDF

Optimizing the diagnosis and assessment of chronic thromboembolic pulmonary hypertension with advancing imaging modalities.

Pulm Circ 2021 Apr-Jun;11(2):20458940211007375. Epub 2021 May 24.

Cardiothoracic Imaging, University of California San Diego, La Jolla, CA, USA.

Imaging is key to nearly all aspects of chronic thromboembolic pulmonary hypertension including management for screening, assessing eligibility for pulmonary endarterectomy, and post-operative follow-up. While ventilation/perfusion scintigraphy, the gold standard technique for chronic thromboembolic pulmonary hypertension screening, can have excellent sensitivity, it can be confounded by other etiologies of pulmonary malperfusion, and does not provide structural information to guide operability assessment. Conventional computed tomography pulmonary angiography has high specificity, though findings of chronic thromboembolic pulmonary hypertension can be visually subtle and unrecognized. Read More

View Article and Full-Text PDF

Analysis of Risk Factors for Rectus Sheath Hematoma.

J Coll Physicians Surg Pak 2021 Jun;30(6):633-637

Department of General Surgery, Medical School, Hitit University, Corum, Turkey.

Objective: To evaluate the risk factors for developing rectus sheath hematoma (RSH).

Study Design: An observational study.

Place And Duration Of Study: Department of General Surgery, Hitit University School of Medicine, Erol Olcok Training and Research Hospital, Turkey; from January 2018 to April 2020. Read More

View Article and Full-Text PDF

Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study.

Osong Public Health Res Perspect 2021 May 26. Epub 2021 May 26.

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran.

Objectives: Coronavirus disease 2019 (COVID-19) is a novel pandemic. Considerable differences in disease severity and the mortality rate have been observed in different parts of the world. The present study investigated the characteristics and outcomes of patients hospitalized with COVID-19 in Iran. Read More

View Article and Full-Text PDF

Intravascular ultrasound-guided catheter-based aspiration thrombectomy in patients with acute submassive pulmonary embolism: A case series.

Cardiovasc Revasc Med 2021 May 19. Epub 2021 May 19.

Division of Cardiology, Atlanta VA Medical Center, Decatur, GA, United States of America. Electronic address:

Contrast pulmonary angiography by hand injection or power injection is widely used during catheter-based therapies for acute submassive and massive pulmonary embolism (PE). Particularly, in patients with pre-existing chronic kidney disease, this approach may present a prognostic challenge owing to a double-contrast load, initially during computed tomographic pulmonary angiography (CTPA), and during percutaneous treatment. Intravascular ultrasound (IVUS) has been used as an adjunctive imaging modality in the percutaneous treatment of chronic thromboembolic pulmonary hypertension, and in coronary and peripheral vascular interventions. Read More

View Article and Full-Text PDF

Two-dimensional transthoracic echocardiography at rest for the diagnosis, screening and management of pulmonary hypertension.

Swiss Med Wkly 2021 May 7;151:w20486. Epub 2021 Jun 7.

Cardiology Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Doppler echocardiography is widely used in everyday clinical practice for the detection of pulmonary hypertension (PH) in symptomatic patients and in populations particularly at risk of pulmonary arterial hypertension (PAH). It allows accurate estimation of systolic pulmonary arterial pressure but may lack precision in particular situations. In addition, echocardiography can help to distinguish between pre- and post-capillary PH and is a very good tool to evaluate right ventricular systolic function, which is of great prognostic interest in PAH. Read More

View Article and Full-Text PDF

Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience.

Eur Heart J Cardiovasc Imaging 2021 Jun 7. Epub 2021 Jun 7.

Bluhm Cardiovascular Institute, Northwestern University, 676 N Saint Clair, Chicago Illinois 60611 USA.

Aims: There is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease.

Methods And Results: Echocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. Read More

View Article and Full-Text PDF

Modified lung ultrasound scoring system to evaluate the feasibility of pregnant women with COVID-19 pneumonia.

J Matern Fetal Neonatal Med 2021 Jun 6:1-6. Epub 2021 Jun 6.

Department of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

Objective: To investigate whether physicians with short-term training can use a modified lung ultrasound scoring system for coronavirus disease 2019 (COVID-19) pneumonia to assess lung damage in pregnant women.

Methods: Sixteen consecutively hospitalized third-trimester pregnant women with pregnancy-induced hypertension, preeclampsia, rheumatoid arthritis or connective tissue disease were selected as the study subjects for the simulation of COVID-19 pneumonia. Two physicians (imaging and internal medicine) without ultrasonic experience performed lung examinations on pregnant women after six days of lung ultrasound training, and their consistency with examinations by the expert was assessed. Read More

View Article and Full-Text PDF

Experimental design of the Effects of Dehydroepiandrosterone in Pulmonary Hypertension (EDIPHY) trial.

Pulm Circ 2021 Apr-Jun;11(2):2045894021989554. Epub 2021 May 21.

Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.

Pulmonary arterial hypertension (PAH) remains life-limiting despite numerous approved vasodilator therapies. Right ventricular (RV) function determines outcome in PAH but no treatments directly target RV adaptation. PAH is more common in women, yet women have better RV function and survival as compared to men with PAH. Read More

View Article and Full-Text PDF

Pulmonary Manifestations of GATA2 Deficiency.

Chest 2021 Jun 3. Epub 2021 Jun 3.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: GATA2 deficiency is a genetic disorder of hematopoiesis, lymphatics, and immunity caused by autosomal dominant or sporadic mutations in GATA2. The disease has a broad phenotype encompassing immunodeficiency, myelodysplasia, leukemia, and vascular or lymphatic dysfunction as well as prominent pulmonary manifestations.

Research Question: What are the pulmonary manifestations of GATA2 deficiency?

Study Design And Methods: A retrospective review was conducted of clinical medical records, diagnostic imaging, pulmonary pathologic specimens, and tests of pulmonary function. Read More

View Article and Full-Text PDF

Clinical outcomes of asymptomatic cardiac involvement in systemic sclerosis patients after a 2-year follow-up (extended study).

Am J Med Sci 2021 Jun 1. Epub 2021 Jun 1.

Division of Rheumatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Background: Asymptomatic cardiac involvement in systemic sclerosis (SSc) has been reported. Long-term follow-up might elucidate the clinical implications of these abnormalities. The aim was to identify the clinical outcomes of asymptomatic cardiac involvement in SSc patients after 2 years of follow-up. Read More

View Article and Full-Text PDF

How to Determine Right Ventricular Dysfunction in Pulmonary Hypertension.

J Cardiovasc Imaging 2021 Apr 14. Epub 2021 Apr 14.

Department of Cardiovascular Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

View Article and Full-Text PDF

Speckle Tracking Imaging in Patients with Pulmonary Hypertension.

J Cardiovasc Imaging 2021 Mar 18. Epub 2021 Mar 18.

Division of Cardiology, Hospital of the Government of the City of Buenos Aires "Dr. Cosme Argerich", Buenos Aires, Argentina.

Background: Right ventricular (RV) systolic dysfunction is a strong predictor of mortality in pulmonary hypertension (PH). The goal of this study was to investigate whether right atrium (RA) and RV myocardial strain related to PH using speckle tracking echocardiography provide a superior estimation of RV systolic function than 2-dimensional (2D)-echo.

Methods: This cross-sectional study analyzed 22 patients with a diagnosis of PH stratified by right heart catheterization, and they were compared to a control group of 22 age- and sex-matched healthy subjects. Read More

View Article and Full-Text PDF

Predictors of subclinical systemic sclerosis primary heart involvement characterised by microvasculopathy and myocardial fibrosis.

Rheumatology (Oxford) 2021 Jun;60(6):2934-2945

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

Objectives: SSc primary heart involvement (SSc-pHI) is a significant cause of mortality. We aimed to characterize and identify predictors of subclinical SSc-pHI using cardiovascular MRI.

Methods: A total of 83 SSc patients with no history of cardiovascular disease or pulmonary arterial hypertension and 44 healthy controls (HCs) underwent 3 Tesla contrast-enhanced cardiovascular MRI, including T1 mapping and quantitative stress perfusion. Read More

View Article and Full-Text PDF

Hypertensive Heartbreak.

N Engl J Med 2021 06;384(22):2145-2152

From Brigham and Women's Hospital, Boston.

View Article and Full-Text PDF

Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?

J Enzyme Inhib Med Chem 2021 Dec;36(1):1230-1235

Department of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.

The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing, a clinically used drug, acetazolamide (a specific inhibitor of carbonic anhydrase, CA, EC 4. Read More

View Article and Full-Text PDF
December 2021

Extensive Left Ventricular Thrombosis with Concomitant Pulmonary Embolism.

Clin Pract 2021 May 18;11(2):303-308. Epub 2021 May 18.

George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș, 38 Gheorghe Marinescu Street, 540142 Târgu Mureș, Romania.

A 57-year-old non-obese female patient with a history of heavy smoking, chronic obstructive pulmonary disease and hypertension was admitted to the hospital as an emergency for acute hemoptysis and signs of congestive heart failure. To assess the source of hemoptysis, computed tomography (CT) pulmonary angiography was performed, which confirmed a bilateral pulmonary embolism of the apical branches. The routinely performed transthoracic echocardiography (TTE) revealed an enlarged left ventricle with severely reduced ejection fraction (EF = 25%) due to global hypokinesia and multiple, mobile, echogenic masses. Read More

View Article and Full-Text PDF