232,912 results match your criteria Pulmonary Function Testing


EXERCISE CAPACITY IN CHILDREN AND ADOLESCENTS WITH POST-INFECTIOUS BRONCHIOLITIS OBLITERANS: A SYSTEMATIC REVIEW.

Rev Paul Pediatr 2019 Mar 18. Epub 2019 Mar 18.

Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objective: To evaluate exercise capacity in children and adolescents with post-infectious bronchiolitis obliterans.

Data Source: This is a systematic review based on data from PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), and Physiotherapy Evidence Database (PEDro). We used the following search strategy: "Exercise capacity OR Exercise Test OR Physical fitness OR Functional capacity OR Six-minute walk test OR Shuttle walk test OR Cardiopulmonary exercise test AND Bronchiolitis obliterans. Read More

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http://dx.doi.org/10.1590/1984-0462/;2019;37;2;00017DOI Listing

Use of Symptoms Scores, Spirometry, and Other Pulmonary Function Testing for Asthma Monitoring.

Front Pediatr 2019 5;7:54. Epub 2019 Mar 5.

Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), University of Bologna, Alma Mater Studiorum, Bologna, Italy.

Asthma is a global problem affecting millions of people all over the world. Monitoring of asthma both in children and in adulthood is an indispensable tool for the optimal disease management and for the maintenance of clinical stability. To date, several resources are available to assess the asthma control, first is the monitoring of symptoms, both through periodic follow-up visits and through specific quality of life measures addressed to the patient in first person or to parents. Read More

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http://dx.doi.org/10.3389/fped.2019.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413670PMC

Comparison of the Forced and Slow Vital Capacity Maneuvers in Defining Airway Obstruction.

Respir Care 2019 Mar 19. Epub 2019 Mar 19.

Graduate Medical Education, Brooke Army Medical Center, JBSA Fort Sam Houston, Texas.

Background: Obstructive lung disease is diagnosed by a decreased ratio of FEV to the vital capacity (VC). Although the most commonly used VC is FVC, American Thoracic Society guidelines suggest alternative VCs, for example, slow VC (SVC), may offer a more-accurate evaluation of breathing capacity. There is recent evidence that using only FEV/FVC underrecognizes obstruction in subjects at high risk and who are symptomatic. Read More

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http://dx.doi.org/10.4187/respcare.06419DOI Listing

Quality of Pulmonary Function Tests in Participants with Down Syndrome.

Arch Bronconeumol 2019 Mar 16. Epub 2019 Mar 16.

Department of Epidemiology and Social Science in Health, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address:

Introduction: People with Down syndrome (DS) have high respiratory morbidity, evaluating their respiratory health with standardized, objective tests is desirable. Thus, the objective of this study was to evaluate the technical quality of Pulmonary Function Tests (PFTs) to determine which ones are most suitable for this population.

Methods: Participants included children, teenagers and adults with DS, 5 years of age or older (n=302). Read More

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http://dx.doi.org/10.1016/j.arbres.2019.02.010DOI Listing

Serum KL-6 is associated with the severity of interstitial lung disease in Chinese patients with polymyositis and dermatomyositis.

Clin Rheumatol 2019 Mar 19. Epub 2019 Mar 19.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College &Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, Beijing, 100730, China.

Objective: This cross-sectional study was designed to assess the clinical significance of the serum KL-6 in the diagnosis of interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathy (IIM).

Methods: We measured serum KL-6 levels in 184 patients with IIM using a chemiluminescent enzyme immunoassay and compared KL-6 levels between patients with and without ILD, according to other clinical features.

Results: IIM patients with ILD had significantly higher serum KL-6 levels than those without ILD (776. Read More

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http://dx.doi.org/10.1007/s10067-019-04501-9DOI Listing

Physical Inactivity in Pulmonary Sarcoidosis.

Lung 2019 Mar 19. Epub 2019 Mar 19.

Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, King's College London, London, UK.

Purpose: Reduced physical activity in many chronic diseases is consistently associated with increased morbidity. Little is known about physical activity in sarcoidosis. The aim of this study was to objectively assess physical activity in patients with pulmonary sarcoidosis and investigate its relationship with lung function, exercise capacity, symptom burden, and health status. Read More

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http://dx.doi.org/10.1007/s00408-019-00215-6DOI Listing

Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Telethon Kids Institute, Nedlands, Western Australia, Australia.

Rationale: Increasing evidence suggests the forced oscillation technique (FOT) has the capacity to provide non-invasive monitoring and diagnosis of respiratory disease in young children. However, which FOT outcomes provide the most pertinent clinical information is currently unknown. The aim of this study was to determine which FOT outcomes were most sensitive for differentiating between health and specific childhood respiratory disease. Read More

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http://dx.doi.org/10.1002/ppul.24286DOI Listing
March 2019
1 Read

[Pulmonary involvement in rheumatoid arthritis].

Z Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Klinik für Rheumatologie, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Pulmonary involvement in patients with rheumatoid arthritis, in particular interstitial lung diseases (RA-ILD) is of great clinical importance. Patients should be asked about symptoms of pulmonary involvement and the lungs should be clinically examined even during the diagnostic procedure and regularly during the course of the disease. Before initiation of a basic pharmacological treatment an X‑ray examination of thoracic organs is obligatory. Read More

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http://dx.doi.org/10.1007/s00393-019-0611-1DOI Listing

Respiratory dysfunction following initiation of mirabegron: A case report.

Respir Med Case Rep 2019 16;26:304-306. Epub 2019 Feb 16.

Northwestern University Feinberg School of Medicine, Division of Pulmonary and Critical Care Medicine, 240 East Huron Street, McGaw Pavilion, Suite M-349 Chicago, Illinois 60611, USA.

Background: Mirabegron, a β3 adrenergic receptor agonist, is FDA approved for treatment of overactive bladder. Approved in 2012 in the US, there have been no reports of any effects of mirabegron on pulmonary function.

Case Presentation: We report the case of a 65 year old male with a history of Parkinson's disease, OSA, and aspiration pneumonia presenting with subacute worsening dyspnea and found to have worsening restrictive ventilatory defect with a pattern consistent with neuromuscular weakness. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402286PMC
February 2019

Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis.

RMD Open 2019 14;5(1):e000820. Epub 2019 Feb 14.

Department of Medicine and Surgery (DiMeC), Unit of Surgical Sciences, Section of Radiology, University of Parma, Parma, Italy.

Objectives: This multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease-ILD, emphysema or neither).

Methods: Chest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397433PMC
February 2019

Experimental and quantitative imaging techniques in interstitial lung disease.

Thorax 2019 Mar 18. Epub 2019 Mar 18.

Academic Unit of Academic Radiology, University of Sheffield, Sheffield, UK.

Interstitial lung diseases (ILDs) are a heterogeneous group of conditions, with a wide and complex variety of imaging features. Difficulty in monitoring, treating and exploring novel therapies for these conditions is in part due to the lack of robust, readily available biomarkers. Radiological studies are vital in the assessment and follow-up of ILD, but currently CT analysis in clinical practice is qualitative and therefore somewhat subjective. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-211779DOI Listing

Can the Sarcoidosis Health Questionnaire predict the long-term outcomes in Japanese sarcoidosis patients?

Respir Med 2019 Mar 11;149:1-8. Epub 2019 Jan 11.

Kyoto Central Clinic, Clinical Research Center, Kyoto, Japan. Electronic address:

Rationale: The Sarcoidosis Health Questionnaire (SHQ) is the first sarcoidosis-specific health status questionnaire ever developed. Worse health status, as evaluated by the SHQ, may indicate higher risk for deterioration in the following 5 years.

Objectives: To evaluate the association between SHQ scores and deterioration defined clinically at 5-year follow-up. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.001DOI Listing

Case report: new development of fibrosing interstitial lung disease triggered by HIV-related pneumocystis pneumonia.

BMC Pulm Med 2019 Mar 18;19(1):65. Epub 2019 Mar 18.

AIDS Clinical Center, National Center of Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Fibrosing interstitial lung disease is the poor prognostic non-infectious lung disease by unknown etiology. Here, we present one case developing interstitial pneumonia with fibrosis after treatment of pneumocystis pneumonia (PCP) in newly diagnosed HIV-1 infected case.

Case Presentation: A previously healthy 63-year old male was referred to our institute because of protracted dyspnea on effort in 2 weeks after pneumocystis pneumonia treatment. Read More

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http://dx.doi.org/10.1186/s12890-019-0831-9DOI Listing

Acute Exacerbation of Idiopathic Pulmonary Fibrosis.

Authors:
Tomoo Kishaba

Medicina (Kaunas) 2019 Mar 16;55(3). Epub 2019 Mar 16.

Department of Respiratory Medicine, Okinawa Chubu Hospital, 904-2293 Miyazato 281, Uruma City, Okinawa, Japan.

Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia. Idiopathic pulmonary fibrosis is often seen in elderly men who smoke. A diagnosis of IPF is based on a combination of a detailed clinical history, specific physical examination, laboratory findings, pulmonary function tests, high-resolution computed tomography (HRCT) of the chest, and histopathology. Read More

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http://dx.doi.org/10.3390/medicina55030070DOI Listing

A coupled approach for identification of nonlinear and compressible material models for soft tissue based on different experimental setups - Exemplified and detailed for lung parenchyma.

J Mech Behav Biomed Mater 2019 Feb 20;94:126-143. Epub 2019 Feb 20.

Institute for Computational Mechanics, Technical University of Munich, Boltzmannstr. 15, 85747 Garching b. München, Germany.

In this paper, a coupled inverse analysis is proposed to identify nonlinear compressible hyperelastic material models described by two sets of experiments. While the overall approach is applicable for different materials, here it will be presented for viable lung parenchyma. Characterizing the material properties of lung parenchyma is essential to describe and predict the mechanical behavior of the respiratory system in health and disease. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.019DOI Listing
February 2019

A Rare Case of Pulmonary Coinfection by Lichtheimia ramosa and Aspergillus fumigatus in a Patient With Delayed Graft Function After Renal Transplantation.

Transplant Proc 2019 Mar 12;51(2):551-555. Epub 2018 Dec 12.

Institute of Organ Transplantation, General Hospital of Chinese People's Armed Police Force, Beijing, China; Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin, China.

Pulmonary coinfection with Mucor and Aspergillus species has not been reported in organ transplant recipients. Here, we report a rare case of pulmonary coinfection with invasive fungal species in a renal transplant recipient with delayed graft function. The patient was first treated with a regime containing voriconazole, but the infection only worsened. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.006DOI Listing

What are the best indicators to assess malnutrition in idiopathic pulmonary fibrosis patients? A cross-sectional study in a referral center.

Nutrition 2018 Dec 19;62:115-121. Epub 2018 Dec 19.

Unité de Nutrition, CHU Rennes, Rennes University Hospital, Rennes, France; INRA, INSERM, Univ Rennes, Nutrition Metabolisms and Cancer, NuMeCan, Rennes, France. Electronic address:

Objectives: Little is known about the indicators to assess malnutrition in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to determine the following: 1) the prevalence of malnutrition in IPF patients; 2) the nutritional indicators predictive of low fat-free mass (FFM) as measured by bioimpedance analysis; 3) the IPF patients' characteristics associated with low FFM.

Methods: The IPF patients were consecutively recruited in a referral center for rare pulmonary diseases. Read More

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http://dx.doi.org/10.1016/j.nut.2018.12.008DOI Listing
December 2018

Left Atrial Dynamics During Exercise in Mitral Regurgitation of Primary and Secondary Origin: Pathophysiological Insights by Exercise Echocardiography Combined With Gas Exchange Analysis.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Cardiology University Department, Heart Failure Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy; Department for Biomedical Sciences for Health, University of Milano, Milan, Italy. Electronic address:

Objectives: The aim of this study was to identify the pattern of exercise left atrial (LA) dynamics, its gas exchange correlates, and prognosis in mitral regurgitation (MR) of primary and secondary origin.

Background: The adaptive response and clinical significance of LA function during exercise in MR is undefined.

Methods: A total of 196 patients with MR (81 with primary MR, 115 with secondary MR) and 54 control subjects underwent exercise stress echocardiography and cardiopulmonary exercise testing with LA function assessment. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.031DOI Listing

Long-term medical and psychosocial outcomes in congenital diaphragmatic hernia survivors.

Arch Dis Child 2019 Mar 15. Epub 2019 Mar 15.

Division of Obstetrics and Gynaecology, University of Western Australia Faculty of Health and Medical Sciences, Perth, Western Australia, Australia.

Objective: Survival rates for congenital diaphragmatic hernia (CDH) are increasing. The long-term outcomes of CDH survivors were compared with a healthy control group to assess the morbidity for guidance of antenatal counselling and long-term follow-up programmes.

Participants And Design: Participants born with CDH in Western Australia 1993-2008 were eligible with matched controls from the general population. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316091DOI Listing

Korean childhood asthma study (KAS): a prospective, observational cohort of Korean asthmatic children.

BMC Pulm Med 2019 Mar 15;19(1):64. Epub 2019 Mar 15.

Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea.

Background: Asthma is a syndrome composed of heterogeneous disease entities. Although it is agreed that proper asthma endo-typing and appropriate type-specific interventions are crucial in the management of asthma, little data are available regarding pediatric asthma.

Methods: We designed a cluster-based, prospective, observational cohort study of asthmatic children in Korea (Korean childhood Asthma Study [KAS]). Read More

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http://dx.doi.org/10.1186/s12890-019-0829-3DOI Listing

An Atypical Case of Idiopathic Pulmonary Fibrosis in a Patient from Africa.

Medicina (Kaunas) 2019 Mar 14;55(3). Epub 2019 Mar 14.

Department of Respiratory Medicine and Allergy, Section of Respiratory Disease and Allergy, B4:09, Karolinska University Hospital, 171 76 Stockholm, Sweden.

A 39 years old African man presented with fatigue, loss of weight and night sweats; radiology showed a possible usual interstitial pneumonia pattern. The patient missed follow-up visits, and presented again after 3 years with productive cough and general illness. Pulmonary function tests showed a decline of FVC compared to a previous investigation. Read More

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https://www.mdpi.com/1010-660X/55/3/67
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http://dx.doi.org/10.3390/medicina55030067DOI Listing
March 2019
2 Reads

Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome.

Anesthesiology 2019 Apr;130(4):572-580

From the Department of Anesthesia, Critical Care, and Emergency, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda - Ospedale Maggiore Policlinico, Milan (MI), Italy (G.G., V.S., D.T., R.R., A.P.) Department of Pathophysiology and Transplantation, University of Milan, Milan (MI), Italy (G.G., F.C., F.B., L.C.M., E.S., A.P.) Department of Preventive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda - Ospedale Maggiore Policlinico, Milan (MI), Italy (L.P.) Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany (L.G.) Department of Health Sciences, University of Milan, Milan (MI), Italy (D.C.).

What We Already Know About This Topic: Extracorporeal membrane oxygenation is used in severe acute respiratory distress syndrome; whereas the long-term complications among survivors of acute respiratory distress syndrome treated without extracorporeal membrane oxygenation are well described, the status of extracorporeal membrane oxygenation survivors is poorly understood WHAT THIS ARTICLE TELLS US THAT IS NEW: In a single-center cohort of acute respiratory distress syndrome survivors, management with (vs. without) extracorporeal membrane oxygenation resulted in similar survival at 1 yr, pulmonary function, and computed tomography lung imaging, but less impairment in quality of life BACKGROUND:: Survivors of acute respiratory distress syndrome (ARDS) have long-term impairment of pulmonary function and health-related quality of life, but little is known of outcomes of ARDS survivors treated with extracorporeal membrane oxygenation. The aim of this study was to compare long-term outcomes of ARDS patients treated with or without extracorporeal membrane oxygenation. Read More

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http://Insights.ovid.com/crossref?an=00000542-201904000-0001
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http://dx.doi.org/10.1097/ALN.0000000000002624DOI Listing
April 2019
10 Reads

SVC Is a Marker of Respiratory Decline Function, Similar to FVC, in Patients With ALS.

Front Neurol 2019 28;10:109. Epub 2019 Feb 28.

Faculdade de Medicina, Instituto de Fisiologia e Instituto de Medicina Molecular, Universidade de Lisboa, Lisbon, Portugal.

Respiratory function is a critical predictor of survival in amyotrophic lateral sclerosis (ALS). We aimed to determine if slow vital capacity (SVC) is a predictor of functional loss in ALS as compared to forced vital capacity (FVC). Consecutive ALS patients in whom respiratory tests were performed at baseline and 6 months later were included. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00109
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http://dx.doi.org/10.3389/fneur.2019.00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403463PMC
February 2019
1 Read

Surgical complication and postoperative pulmonary function in patients undergoing tumor surgery with thoracic wall resection.

Oncol Lett 2019 Mar 31;17(3):3446-3456. Epub 2019 Jan 31.

Department of Orthopedic Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan.

Postoperative complications of thoracic wall resection include respiratory complications, skin necrosis and infection. The aim of the present study was to examine postoperative complications in patients who required combined thoracic wall resection during the surgical removal of a tumor. The present study included 68 patients; there were 50 patients with lung tumors and 18 patients with musculoskeletal tumors. Read More

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http://dx.doi.org/10.3892/ol.2019.9997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396184PMC

Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study.

Respir Res 2019 Mar 12;20(1):56. Epub 2019 Mar 12.

Department of Medicine, University of British Columbia, Vancouver, Canada.

Background: Patients with fibrotic interstitial lung disease (ILD) are frequently physically inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the importance of body composition, muscle strength, and physical performance in this population is largely unknown.

Methods: Patients were prospectively recruited from a specialized ILD clinic, baseline characteristics were collected from the clinical record, pulmonary function tests were performed per established protocols, and dyspnea was measured using the University of California San Diego Shortness of Breath Questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to assess body composition; handgrip strength to determine muscle strength, and 4-m gait speed to measure physical performance. Read More

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http://dx.doi.org/10.1186/s12931-019-1019-9DOI Listing
March 2019
1 Read

Maternal and neonatal 25-hydroxyvitamin D concentrations and school age lung function, asthma and allergy. The Generation R Study.

Clin Exp Allergy 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Division of Respiratory Medicine and Allergology.

Background: Vitamin D deficiency in early life might affect the developing lung and immune system, and subsequently influence the risk of asthma and allergy in later life.

Objective: We examined the associations of 25-hydroxyvitamin D concentrations in mid-gestation and at birth with lung function, asthma, inhalant allergic sensitization and inhalant allergy at school age.

Methods: This study among 4,951 children and their mothers was embedded in a population-based prospective cohort in Rotterdam, the Netherlands. Read More

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http://dx.doi.org/10.1111/cea.13384DOI Listing

Genetic causes of surfactant protein abnormalities.

Authors:
Lawrence M Nogee

Curr Opin Pediatr 2019 Mar 6. Epub 2019 Mar 6.

Eudowood Neonatal Pulmonary Division, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: Mutations in genes encoding proteins critical for the production and function of pulmonary surfactant cause diffuse lung disease. Timely recognition and diagnosis of affected individuals is important for proper counseling concerning prognosis and recurrence risk.

Recent Findings: Involved genes include those encoding for surfactant proteins A, B, and C, member A3 of the ATP-binding cassette family, and for thyroid transcription factor 1. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000751DOI Listing
March 2019
1 Read

Pulmonary Densitovolumetry Using Computed Tomography in Patients with Nontuberculous Mycobacteria: Correlation with Pulmonary Function Tests.

Pulm Med 2019 3;2019:5942783. Epub 2019 Feb 3.

Post-Graduate Program in Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Since nontuberculous mycobacterial pulmonary disease (NTM-PD) is a condition with increasing morbidity, a more detailed knowledge of radiological aspects and pulmonary function plays a relevant role in the diagnosis and appropriate therapeutic management of these patients.

Objectives: The purpose of this study was to evaluate changes in lung parenchyma through computed tomography (CT) densitometry and, secondarily, to analyze its correlation with pulmonary function testing (PFT) in patients with NTM-PD.

Methods: This is a cross-sectional study in which 31 patients with NTM-PD and 27 controls matched by sex, age, and body mass index underwent CT pulmonary densitovolumetry and pulmonary function tests including spirometry and body plethysmograph. Read More

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http://dx.doi.org/10.1155/2019/5942783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377979PMC
February 2019
1 Read

Effect of changing reference equations for spirometry interpretation in Thai people.

J Thorac Dis 2019 Jan;11(1):113-122

Division of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Use of different spirometry reference equations can lead to misinterpretation of spirometry results. Currently, no study has been carried out to determine if there is any discordance between the interpretation of spirometry data using the Global Lungs Initiative (GLI) 2012, the Third National Health and Nutrition Examination Survey (NHANES III), the Knudson, and the Siriraj reference equations in Thai people. Therefore, this study aimed to determine differences and agreements regarding spirometry results using the GLI2012, NHANES III, Knudson, and Siriraj reference equations in a Thai population. Read More

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http://dx.doi.org/10.21037/jtd.2018.11.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384371PMC
January 2019

Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.

Nutrients 2019 Mar 9;11(3). Epub 2019 Mar 9.

Departamento de Biomedicina-Unidade de Bioquímica, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal.

Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Read More

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https://www.mdpi.com/2072-6643/11/3/583
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http://dx.doi.org/10.3390/nu11030583DOI Listing
March 2019
2 Reads

Comparison of laryngeal mask airway supremeTM as non-inflatable cuff device and self-pressurized air-QTM in children: Randomized controlled non-inferiority study.

Medicine (Baltimore) 2019 Mar;98(10):e14746

Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.

Background: Supraglottic airway (SGA) device with non-inflatable cuff reduce the airway complications associated with cuff hyperinflation. The aim of the study is to determine whether the default setting of Supreme is as effective as the non-inflatable cuff devices. The oropharyngeal leak pressure was measured and compared between the Supreme and Air-Q, a typical non-inflatable cuff device. Read More

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http://dx.doi.org/10.1097/MD.0000000000014746DOI Listing
March 2019
1 Read

Perioperatively Acquired Weakness.

Anesth Analg 2019 Mar 4. Epub 2019 Mar 4.

From the Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Skeletal muscle failure in critical illness (intensive care unit-acquired weakness) is a well-known complication developing early during intensive care unit stay. However, muscle weakness during the perioperative setting has not yet been investigated.

Methods: We performed a subgroup investigation of a prospective observational trial to investigate perioperative muscle weakness. Read More

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http://Insights.ovid.com/crossref?an=00000539-900000000-9625
Publisher Site
http://dx.doi.org/10.1213/ANE.0000000000004068DOI Listing
March 2019
7 Reads

Clinical Characteristics of Relapsing Polychondritis: A Report of 8 Cases in Japan.

Kurume Med J 2019 Mar 11. Epub 2019 Mar 11.

Division of Respirology, Neurology and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine.

Objectives: Relapsing polychondritis (RP) is a very rare autoimmune disorder characterized by recurrent episodes of inflammation and destruction of cartilaginous tissues. We examined the clinical characteristics, management, and outcomes of Japanese RP patients.

Methods: We identified 8 RP cases in our department between 2003 and 2017. Read More

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https://www.jstage.jst.go.jp/article/kurumemedj/advpub/0/adv
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http://dx.doi.org/10.2739/kurumemedj.MS652006DOI Listing
March 2019
2 Reads

Assessment of breath volatile organic compounds in acute cardiorespiratory breathlessness: a protocol describing a prospective real-world observational study.

BMJ Open 2019 Mar 8;9(3):e025486. Epub 2019 Mar 8.

Department of Respiratory Sciences, College of Life Sciences, University of Leicester, Leicester, UK.

Introduction: Patients presenting with acute undifferentiated breathlessness are commonly encountered in admissions units across the UK. Existing blood biomarkers have clinical utility in distinguishing patients with single organ pathologies but have poor discriminatory power in multifactorial presentations. Evaluation of volatile organic compounds (VOCs) in exhaled breath offers the potential to develop biomarkers of disease states that underpin acute cardiorespiratory breathlessness, owing to their proximity to the cardiorespiratory system. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02548
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-025486DOI Listing
March 2019
3 Reads

Extended criteria donor lungs do not impact recipient outcomes in pediatric transplantation.

J Heart Lung Transplant 2019 Feb 27. Epub 2019 Feb 27.

Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; German Centre for Lung Research, BREATH site, Hannover, Germany. Electronic address:

Background: Pediatric lung transplantation remains the only curative treatment option for some end-stage lung diseases in childhood. Recipient numbers outnumber potential donor organs, and therefore a broader group of donor organs must be considered for pediatric lung transplantation. Herein we describe the outcome of utilizing extended criteria donor organs in pediatric lung transplantation. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.012DOI Listing
February 2019
1 Read

Histological, Ultrastructural, and Physiological Evaluation of a Rat Model of Obstructive Sleep Apnea Syndrome.

Med Sci Monit 2019 Mar 9;25:1806-1813. Epub 2019 Mar 9.

The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China (mainland).

BACKGROUND Patients with obstructive sleep apnea syndrome (OSAS) are at an increased risk of cardiovascular disease. The aims of this study were to develop a rat model of OSAS and to validate the use of the model by investigating respiratory and cardiovascular physiological parameters and morphological changes by light microscopy and electron microscopy. MATERIAL AND METHODS Sixty 3-month-old Sprague-Dawley rats were assigned to the model group (n=30) and the control group (n=30). Read More

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http://dx.doi.org/10.12659/MSM.913056DOI Listing
March 2019
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Diaphragmatic Neurophysiology and Respiratory Markers in ALS.

Front Neurol 2019 21;10:143. Epub 2019 Feb 21.

Instituto de Fisiologia-Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

The main reason for short survival in amyotrophic lateral sclerosis (ALS) is involvement of respiratory muscles. Severe compromise of diaphragmatic function due to marked loss of motor units causes poor inspiratory strength leading to symptomatic respiratory fatigue, and hypercapnia and hypoxemia, often firstly detected while sleeping supine. Weakness of expiratory muscles leads to cough weakness and poor bronchial clearance, increasing the risk of respiratory infection. Read More

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http://dx.doi.org/10.3389/fneur.2019.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393326PMC
February 2019
1 Read

Respiratory resistance and reactance in adults with sickle cell anemia: Part 2-Fractional-order modeling and a clinical decision support system for the diagnosis of respiratory disorders.

PLoS One 2019 7;14(3):e0213257. Epub 2019 Mar 7.

Biomedical Instrumentation Laboratory-Institute of Biology and Faculty of Engineering, and BioVasc Research Laboratory-Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: A better understanding of sickle cell anemia (SCA) and improvements in drug therapy and health policy have contributed to the emergence of a large population of adults living with this disease. The mechanisms by which SCA produces adverse effects on the respiratory system of these patients are largely unknown. Fractional-order (FrOr) models have a high potential to improve pulmonary clinical science and could be useful for diagnostic purposes, offering accurate models with an improved ability to mimic nature. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213257PLOS
March 2019
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Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis.

Int J Infect Dis 2019 Mar 4. Epub 2019 Mar 4.

Division of Infectious Diseases Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Background: Post-treatment morbidity among subjects withdrug-resistant tuberculosis (DR-TB) is unclear.

Methods: A cross-sectionalstudyof cavitary DR-TB subjects with an outcome of cure from Tbilisi, Georgia. Participants had a chest x-ray (CXR), St. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.039DOI Listing
March 2019
2 Reads

Acute Respiratory Failure Survivors' Physical, Cognitive and Mental Health Outcomes: Quantitative Measures vs. Semi-structured Interviews.

Ann Am Thorac Soc 2019 Mar 7. Epub 2019 Mar 7.

Johns Hopkins University, Pulmonary & Critical Care Medicine, Baltimore, Maryland, United States.

Rationale: Increasingly, patients are surviving acute respiratory failure (ARF), prompting the need to better understand standardized outcome measures commonly used during ARF follow-up studies.

Objectives: Investigate standardized outcome measures (patient-reported physical and mental health measures, and cognitive testing) compared to findings from semi-structured, qualitative interviews.

Methods: As part of two ARF multi-center follow-up studies, standardized outcome measures were obtained, followed by qualitative evaluation via an in-depth, semi-structured interview conducted and coded by two independent researchers. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201812-851OCDOI Listing
March 2019
2 Reads

Cardiorespiratory parameters in infants cardiopathy: variations during feeding.

Codas 2019 Mar 7;31(2):e20180153. Epub 2019 Mar 7.

Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA - Porto Alegre (RS), Brasil.

Purpose: To evaluate the variation of cardiorespiratory parameters in the feeding of cardiopathy infants.

Methods: A cross-sectional, controlled study was performed on infants from 0 to 6 months of age, both genders, at a referral hospital for pediatric cardiac surgery. They were divided into a group study of infants with a medical diagnosis of congenital heart disease, post-cardiac surgery and in a control group composed of infants with no co-morbidities pre-established as risk factors for dysphagia. Read More

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http://dx.doi.org/10.1590/2317-1782/20182018153DOI Listing
March 2019
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Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe MR.

NMR Biomed 2019 Mar 7:e4068. Epub 2019 Mar 7.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China.

Pulmonary diseases usually result in changes of the blood-gas exchange function in the early stages. Gas exchange across the respiratory membrane and gas diffusion in the alveoli can be quantified using hyperpolarized Xe MR via chemical shift saturation recovery (CSSR) and diffusion-weighted imaging (DWI), respectively. Generally, CSSR and DWI data have been collected in separate breaths in humans. Read More

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http://dx.doi.org/10.1002/nbm.4068DOI Listing
March 2019
2 Reads

Age-Dependent Pulmonary Reactivity to House Dust Mite Allergen: A Model of Adult-Onset Asthma?

Am J Physiol Lung Cell Mol Physiol 2019 Mar 6. Epub 2019 Mar 6.

Center for Health and the Environment, University of California, Davis, United States.

Asthma is a heterogeneous disease differentiated by factors like allergen sensitivity, inflammation, sex, and onset age. The mouse model is widely used for studying the early life development of allergic asthma. However, age-dependent allergen responses later in life remain relatively understudied and lack a widely accepted model. Read More

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http://dx.doi.org/10.1152/ajplung.00468.2018DOI Listing
March 2019
2 Reads

Endoscopic Lung Volume Reduction: An Expert Panel Recommendation - Update 2019.

Respiration 2019 Mar 5:1-10. Epub 2019 Mar 5.

Division of Pulmonary and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Endoscopic lung volume reduction (ELVR) therapies are gaining prominence as a treatment option with guideline recommendations by COPD GOLD and NICE and the recent FDA approval for endobronchial valves. The transition from an experiment-based therapy only to clinical care comes with new challenges. A significant volume of evidence-based data has been published; all data demonstrate consistent improvements in several aspects of patient outcomes. Read More

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http://dx.doi.org/10.1159/000496122DOI Listing
March 2019
3 Reads

Changes in persistent asthma care and outcomes from 2006 to 2016 in France.

J Allergy Clin Immunol Pract 2019 Mar 2. Epub 2019 Mar 2.

PELyon, PharmacoEpidemiology Lyon, Lyon, France; Respiratory Medicine, Croix Rousse University Hospital, and EA7426 University Claude Bernard Lyon-1, Lyon, France; HESPER 7425, Health Services and Performance Research, University Claude Bernard Lyon 1, Lyon, France.

Background: Changes in asthma care need to be documented at arrival of biotherapies.

Objectives: To characterize changes in asthma care and outcomes in patients with persistent asthma.

Methods: Repeated transversal analyses were conducted on a historical cohort using the French national claims data over 10 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193020
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http://dx.doi.org/10.1016/j.jaip.2019.02.025DOI Listing
March 2019
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Pulmonary function abnormalities are common in patients with multiple myeloma and are independently associated with worse outcome.

Ann Hematol 2019 Mar 5. Epub 2019 Mar 5.

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 80 Vasilissis Sofias, 11258, Athens, Greece.

Pre-existing pulmonary disease may affect treatment choices, toxicity, and survival of patients with multiple myeloma (MM). However, data on the prognostic value of pulmonary function tests (PFTs) in myeloma patients' outcome, at the time of initial assessment of newly diagnosed patients, are scarce. Here, we prospectively performed PFTs in 121 newly diagnosed MM patients, before initiation of treatment, and we evaluated possible associations of lung function with their outcomes. Read More

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http://dx.doi.org/10.1007/s00277-019-03641-xDOI Listing
March 2019
3 Reads

Clinical characteristics and outcome in patients with antisynthetase syndrome associated interstitial lung disease: a retrospective cohort study.

Eur Clin Respir J 2019 27;6(1):1583516. Epub 2019 Feb 27.

Department of Respiratory Diseases, Sydvestjydsk Regional Hospital, Esbjerg, Denmark.

: To describe the clinical characteristics including the bronchoalveolar lavage fluid (BALF) characteristics of patients with antisynthetase syndrome (AS) associated interstitial lung disease (ILD) in a tertiary ILD outpatient clinic, their medical therapy and outcome. : Retrospective cohort study of patients with AS-ILD. All available data of clinical characteristics, pulmonary function tests, laboratory parameters, BALF analysis, histology, high-resolution computed tomography (HRCT) and treatment were collected from the patient files. Read More

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http://dx.doi.org/10.1080/20018525.2019.1583516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394310PMC
February 2019
3 Reads

Application of the forced oscillation technique in diagnosing and monitoring asthma in preschool children.

Adv Respir Med 2019 Mar 4. Epub 2019 Mar 4.

Centrum Medyczne LA Dymek, ul. Parafialna 1, 47-100 Strzelce Opolskie, Poland.

The measurement of lung function in preschool children for the diagnosis of asthma is not routinely used. The need to perform forced expiratory manoeuvres requires active cooperation and thus limits the use of spirometry in this age group. The forced oscillation technique (FOT) is a simple and noninvasive method of assessing the mechanical properties of the respiratory system during tidal breathing. Read More

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https://journals.viamedica.pl/advances_in_respiratory_medici
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http://dx.doi.org/10.5603/ARM.a2019.0005DOI Listing
March 2019
5 Reads

Determining the optimal time to assess the reversibility of airway obstruction.

Lung India 2019 Mar-Apr;36(2):123-130

Department of Pulmonary, Internal Security Forces Hospital, La Marsa, Tunisia.

Context: The optimal time to interpret bronchodilator reversibility remains controversial. This time may affect a positive diagnosis and manage asthma and chronic obstructive pulmonary disease (COPD).

Aims: We sought to document the time when maximum respiratory function is reached after inhalation of salbutamol and to define the optimal time of bronchodilator response to assess the reversibility or non reversibility of airway obstruction. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_184_18DOI Listing
March 2019
2 Reads

Correlation of spirometry and body plethysmography during exercise-induced bronchial obstruction.

Respir Med 2019 Mar 29;148:54-59. Epub 2019 Jan 29.

Department for Children and Adolescents, Allergy, Pulmonology, and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, Germany. Electronic address:

Background: The exercise challenge is the gold standard for diagnosing exercise-induced bronchoconstriction (EIB). Airway obstructions appear up to 30 min after the challenge, with a maximum decrease in spirometry and a maximum increase in airway resistance. There is evidence that changes in body plethysmography parameters are more sensitive to the exercise challenge and precede those in spirometry. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.011DOI Listing
March 2019
1 Read