241,645 results match your criteria Pulmonary Function Testing


Machine learning for automatic identification of thoracoabdominal asynchrony in children.

Pediatr Res 2020 Jul 3. Epub 2020 Jul 3.

Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

Background: The current methods for assessment of thoracoabdominal asynchrony (TAA) require offline analysis on the part of physicians (respiratory inductance plethysmography (RIP)) or require experts for interpretation of the data (sleep apnea detection).

Methods: To assess synchrony between the thorax and abdomen, the movements of the two compartments during quiet breathing were measured using pneuRIP. Fifty-one recordings were obtained: 20 were used to train a machine-learning (ML) model with elastic-net regularization, and 31 were used to test the model's performance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-020-1032-1DOI Listing

ANTENATAL CORTICOSTEROIDS DECREASE FORCED VITAL CAPACITY IN INFANTS BORN FULLTERM.

Pediatr Pulmonol 2020 Jul 3. Epub 2020 Jul 3.

Departments of Pediatrics-Division of Pulmonology, Indiana University School of Medicine, Indianapolis, Indiana.

Antenatal corticosteroids (ACS) administration to pregnant women for threatened preterm labor is standard obstetric care to reduce neonatal respiratory distress syndrome and the associated respiratory morbidity. While ACS stimulates surfactant production in the fetal lung, the effects of ACS upon the subsequent growth and development of the lung are unclear. Follow-up studies outside of the neonatal period have been primarily limited to spirometry, and most subjects evaluated were born prematurely. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24941DOI Listing

Negative Impact of Obesity on Ventricular Size and Function and Exercise Performance in Children and Adolescents with Repaired Tetralogy of Fallot.

Can J Cardiol 2020 Jun 29. Epub 2020 Jun 29.

Division of Cardiology, Department of Pediatrics, University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, , Toronto, Ontario, Canada. Electronic address:

Background: Up to 25% of children with congenital heart disease are obese, which may have negative physiologic consequences for patients with repaired tetralogy of Fallot (rTOF).

Methods: Patients with rTOF who underwent cardiac magnetic resonance (CMR) and cardiopulmonary exercise testing from 2007-2018 were reviewed. Complex rTOF patients were excluded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2020.06.015DOI Listing

Mechanisms of exercise limitation and prevalence of pulmonary hypertension in pulmonary Langerhans cell histiocytosis.

Chest 2020 Jun 29. Epub 2020 Jun 29.

Divisão de Pneumologia, Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Background: Pulmonary Langerhans cell histiocytosis (PLCH) determines reduced exercise capacity. The speculated mechanisms of exercise impairment in PLCH are ventilatory and cardiocirculatory limitations, including pulmonary hypertension (PH).

Research Question: What are the mechanisms of exercise limitation, the exercise capacity and the prevalence of dynamic hyperinflation (DH) and PH in PLCH?

Study Design And Methods: In a cross-sectional study, PLCH patients underwent an incremental treadmill cardiopulmonary exercise test with an evaluation of DH, pulmonary function tests, and transthoracic echocardiography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2020.05.609DOI Listing

Respiratory effects of road pollution in recreational cyclists: a pilot study.

Arch Environ Occup Health 2020 Jul 2:1-9. Epub 2020 Jul 2.

School of Community Health Sciences, University of Nevada, Reno, NV, USA.

We sought to measure bicyclists' roadway exposures to particulate matter and assess whether those exposures are associated with reduced pulmonary function. Thirty-one (31) volunteer participants riding bicycles on selected routes were tracked using the Global Positioning System. Personal exposures to particulate matter (PM-10) were measured during the rides and pulmonary function tests were administered at baseline, immediately after the ride, and 2 and 6-24 hours later. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19338244.2020.1787316DOI Listing

Skin prick reactivity among asthmatics in East Africa.

World Allergy Organ J 2020 Jun 23;13(6):100130. Epub 2020 Jun 23.

Makerere University Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: The burden of asthma in Africa is high, and yet the disease is not universally prioritised. Data on allergic asthma and its impact on asthma morbidity are limited in Africa. Our aim was to describe the distribution of skin prick positivity among asthmatics in Eastern Africa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.waojou.2020.100130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322185PMC

Auditory Function of Patients with Obstructive Sleep Apnea Syndrome: A Study.

Eurasian J Med 2020 Jun 4;52(2):176-179. Epub 2020 Jun 4.

Department of Otorhinolaryngology, Ataturk University School of Medicine, Erzurum, Turkey.

Objective: Obstructive sleep apnea syndrome (OSAS) is a respiratory syndrome that manifests during sleep. For the auditory system to be able to function normally, the inner ear and cochlear nerve require healthy oxygen support. The purpose of this study was to assess the hearing function of patients with OSAS and to reveal the relationship between polysomnographic parameters and hearing test results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/eurasianjmed.2019.18373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311141PMC

Comparison of Functional Capacity and Symptoms of COPD Patients with and without Pulmonary Hypertension.

Eurasian J Med 2020 Jun 2;52(2):166-170. Epub 2020 Jun 2.

Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Turkey.

Objective: Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD) associated with a decrease in the survival rate of patients with COPD. Our aim was to investigate whether PH impairs the functional capacity and symptoms in patients with COPD. In addition, we aimed to evaluate the correlation between the functional capacity and symptoms score in patients with COPD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/eurasianjmed.2020.19391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311132PMC

Differences Between Central Airway Obstruction and Chronic Obstructive Pulmonary Disease Detected with the Forced Oscillation Technique.

Int J Chron Obstruct Pulmon Dis 2020 19;15:1425-1434. Epub 2020 Jun 19.

The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Background: Obstructive ventilatory disturbances occur in both chronic obstructive pulmonary disease (COPD), a typical disease representative of peripheral airway obstruction, and central airway obstruction (CAO). Pulmonary function tests (PFTs), which depend on patient effort, are traditionally used to evaluate lung function. The forced oscillation technique (FOT) is an effort-independent method for examining lung function during tidal breathing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S246126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310967PMC

COPD Overdiagnosis and Its Effect on 30-Day Hospital Readmission Rates.

Respir Care 2020 Jun 30. Epub 2020 Jun 30.

Respiratory Institute, Cleveland Clinic Main Campus, Cleveland, Ohio.

Background: Although specific guidelines exist for diagnosing COPD on the basis of spirometry testing data (FEV/FVC < 0.70 or above the lower limit of normal), the literature suggests that overdiagnosis is common. Whether overdiagnosis increases 30-d readmission rates has not yet been explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4187/respcare.07536DOI Listing

Successful treatment of coronavirus disease 2019 in a patient with asthma.

Allergy Asthma Proc 2020 Jul;41(4):296-300

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Underlying lung disease, especially asthma, has recently been found to be associated with a higher risk of hospitalization with coronavirus disease 2019 (COVID-19) infection. Inhaled corticosteroids (ICS) are the most commonly used controller medications in patients with asthma. It is unclear whether ICS use increases the risk for severe COVID-19 infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2500/aap.2020.41.200044DOI Listing

Short-term effect of osteopathic manual techniques (OMT) on respiratory function in healthy individuals.

PLoS One 2020 30;15(6):e0235308. Epub 2020 Jun 30.

Department of Health Sciences, Physiotherapy Unit, University of Medical Science, Poznań, Poland.

Background: Respiratory system diseases are some of the most common pathologies worldwide. Although osteopathic manual therapy (OMT) is used predominantly to treat other pathologies, certain OMT techniques have been shown to improve patients' respiratory function.

Objectives: The aim of this study was to assess the influence of osteopathic techniques on breathing. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235308PLOS

Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis.

Allergol Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.

Background: Condition of asthma in patients with asthma and concomitant seasonal allergic rhinitis (SAR) deteriorates during the Japanese cedar pollen (JCP) season. However, the underlying mechanisms remain unclear.

Methods: We analyzed seasonal variations in eicosanoid levels in the airways of patients with asthma and concomitant SAR sensitized to JCP (N = 29, BA-SAR-JCP group) and those not sensitized (N = 13, BA-AR-non-JCP group) during the JCP season. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2020.04.014DOI Listing

Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase.

Respir Res 2020 Jun 29;21(1):163. Epub 2020 Jun 29.

Department of Pulmonary and Critical Care Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 52 East Meihua Rd, Zhuhai City, 519000, China.

Objective: This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase.

Methods: A retrospective study of COVID-19 patients at the Fifth Affiliated Hospital of Sun Yat-sen University were conducted, with serial assessments including lung volumes (TLC), spirometry (FVC, FEV1), lung diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-min walking distance (6MWD) and high resolution CT being collected at 30 days after discharged.

Results: Fifty-seven patients completed the serial assessments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-020-01429-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323373PMC

Lung Function Testing and Prediction Equations in Adult Population from Maputo, Mozambique.

Int J Environ Res Public Health 2020 Jun 24;17(12). Epub 2020 Jun 24.

Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), 80802 Munich, Germany.

Local spirometric prediction equations are of great importance for interpreting lung function results and deciding on the management strategies for respiratory patients, yet available data from African countries are scarce. The aim of this study was to collect lung function data using spirometry in healthy adults living in Maputo, Mozambique and to derive first spirometric prediction equations for this population. We applied a cross-sectional study design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17124535DOI Listing

Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study.

Lancet Respir Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; Beijing Chao-Yang Hospital, Department of Respiratory Medicine, Capital Medical University, Beijing, China. Electronic address:

Background: Small airway dysfunction is a common but neglected respiratory abnormality. Little is known about its prevalence, risk factors, and prognostic factors in China or anywhere else in the world. We aimed to estimate the prevalence of small airway dysfunction using spirometry before and after bronchodilation, both overall and in specific population subgroups; assess its association with a range of lifestyle and environmental factors (particularly smoking); and estimate the burden of small airway dysfunction in China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(20)30155-7DOI Listing

Integrated Analysis of a Gene Correlation Network Identifies Critical Regulation of Fibrosis by lncRNAs and TFs in Idiopathic Pulmonary Fibrosis.

Biomed Res Int 2020 2;2020:6537462. Epub 2020 Jun 2.

Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University & National Clinical Research Base of Traditional Chinese Medicine, Urumqi, Xinjiang 830000, China.

Idiopathic pulmonary fibrosis (IPF), the most frequent form of irreversible interstitial pneumonia with unknown etiology, is characterized by massive remodeling of lung architecture and followed by progressive loss of lung function. However, the key regulatory genes and the specific signaling pathways involved in the onset and progression of IPF still remain unclear. The present study is aimed at investigating the key role of long noncoding RNAs (lncRNAs) and transcription factors (TFs) involved in the pathogenesis of IPF through the integrated analysis of three gene expression profiles from the GEO dataset (GSE2052, GSE44723, and GSE24206). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/6537462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290873PMC

Exhaled carbon monoxide levels in infants and toddlers with episodic asthma.

Fukushima J Med Sci 2020 Jun 27. Epub 2020 Jun 27.

Department of Pediatrics, Fukushima Medical University.

Objective: There are few lung function tests available to evaluate bronchial asthma in infants and toddlers. The objective of this study was to test the hypothesis that the measurement of exhaled carbon monoxide (eCO) levels is applicable to evaluate infants and toddlers with stable asthma and during acute asthma attack.

Methods: A one-way valve breath sampling bag was developed to collect the exhaled air of infants and toddlers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5387/fms.2019-02DOI Listing

Health Effects of Trimellitic Anhydride Occupational Exposure: Insights from Animal Models and Immunosurveillance Programs.

Clin Rev Allergy Immunol 2020 Jun 27. Epub 2020 Jun 27.

Division of Immunology, Allergy Section, Department of Internal Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.

Acid anhydrides are used by chemical industries as plasticizers. Trimellitic acid (TMA) is an acid anhydride widely utilized in factories to produce paints, varnishes, and plastics. In addition to causing direct irritant effects, TMA can augment antibody responses in exposed factory workers leading to occupational asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-020-08801-wDOI Listing

Single ventricle systolic function and cardiopulmonary exercise performance in adult patients with Fontan circulation.

Int J Cardiol 2020 Jun 25. Epub 2020 Jun 25.

Adult Congenital Heart Disease Department, Institute of Cardiology, Warsaw, Poland.

Objective: We employed echocardiographic tissue characterization for the assessment of single ventricle systolic function and examined its relationship with cardiopulmonary exercise testing (CPET) performance in the Fontan circulation.

Methods: 40 consecutive adult Fontan patients (16 female, 24 male; mean age 26.3 ± 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2020.06.024DOI Listing

Preoperative Evaluation for Thoracic Surgery.

Thorac Surg Clin 2020 Aug 22;30(3):241-247. Epub 2020 May 22.

Boston University School of Medicine, Boston, MA, USA.

Preoperative evaluation before thoracic surgery aims to separate those patients who will tolerate surgery and those who are not surgical candidates. Predicted postoperative pulmonary function testing helps make this distinction. The preoperative period represents a time for patient engagement and physical optimization to improve postoperative outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thorsurg.2020.04.003DOI Listing

Is population's cardiorespiratory fitness really declining?

Cent Eur J Public Health 2020 Jun;28(2):120-123

Department of Respiratory Medicine, Faculty of Medicine, Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.

Objective: Cardiorespiratory fitness (CRF) is defined as the capacity of the cardiovascular and pulmonary systems to meet the oxygen demands of the body during physical work. Poor CRF is connected with a higher risk for the development of various noninfectious diseases such as cardiovascular disease or malignancies. The standard test for the assessment of CRF is exercise testing with the measurement of maximal oxygen consumption (VO max). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21101/cejph.a5912DOI Listing

Technical validity and usability of a novel smartphone connected spirometry device for pediatric patients with asthma and cystic fibrosis.

Pediatr Pulmonol 2020 Jun 27. Epub 2020 Jun 27.

Juliana Children's Hospital, HAGA teaching Hospital, the Hague, the Netherlands.

Background: Diagnosis and follow-up of respiratory diseases traditionally rely on pulmonary function tests (PFT), which are currently performed in hospitals and require trained personnel. Smartphone connected spirometers, like the Air Next spirometer, have been developed to aid in the home-monitoring of patients with pulmonary disease. The aim of this study was to investigate the technical validity and usability of the Air Next spirometer in pediatric patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24932DOI Listing

Clinical features and risk factors in patients with asthma complicated with obstructive sleep apnea-hypopnea syndrome: a hospital-based study.

Sleep Breath 2020 Jun 27. Epub 2020 Jun 27.

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongti South Road, Chaoyang District, Beijing, 100020, China.

Purpose: The current study was conducted to explore the clinical features and risk factors of patients with asthma complicated by obstructive sleep apnea-hypopnea syndrome (OSAHS).

Methods: Patients with asthma who underwent polysomnography in our hospital from August 2017 to December 2019 were enrolled in the study. Data on demographics, pulmonary function testing, polysomnography, blood gases, mean pulmonary artery pressure, and vascular endothelial growth factor (VEGF) were compared between the two groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11325-020-02127-9DOI Listing

Decreased Pulmonary Function Over 5 Years in US Firefighters.

J Occup Environ Med 2020 Jun 24. Epub 2020 Jun 24.

Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, NY 12866, USA (Dr Mathias, Dr Graham, Dr Smith); Public Safety Occupational Health Center, 12099 Government Center Parkway, Fairfax, VA 22030, USA (Dr Stewart) and Illinois Fire Service Institute, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA (Dr Smith).

Objective: To examine changes in pulmonary function over a 5-year period in US firefighters.

Methods: Spirometry values from occupational medical exams separated by 5 years (2009-2016) were examined from 662 career firefighters in Virginia. Predicted values and expected 5-year changes in one-second forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC were estimated using reference equations generated from NHANES III data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JOM.0000000000001944DOI Listing

The Remaining Barriers to Normalcy in CF: Advances in Assessment of CF Lung Disease.

Pediatr Pulmonol 2020 Jun 26. Epub 2020 Jun 26.

Division of Pediatric Pulmonology, Allergy, and Sleep Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Despite early diagnosis of cystic fibrosis (CF) through newborn screening, a substantial proportion of infants and young children with CF still demonstrate physiologic and structural evidence of lung disease progression, such as obstructive airway disease and bronchiectasis. The growing availability of highly effective CF transmembrane conductance regulatory modulator therapy to the vast majority of people with CF has led to the potential to alter the natural history of CF lung disease, but in order to assess the full impact of these therapies on CF lung disease and to help guide treatment, sensitive measures of early and mild disease are needed. Chest imaging using computed tomography or magnetic resonance imaging is one approach, but technologic barriers and/or concern about exposure to ionizing radiation may limit its use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24929DOI Listing

Fatal course of clofazimine-induced pulmonary crystal deposition in a patient with Melkersson-Rosenthal syndrome
.

Int J Clin Pharmacol Ther 2020 Jun 26. Epub 2020 Jun 26.

A wide variety of drugs and substances have the potential to damage the respiratory system by different mechanisms. Clofazimine is an anti-leprosy drug that is normally only prescribed for a few years. It has a very long half-life, and crystalline deposition of the drug in various tissues has been documented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5414/CP203784DOI Listing

Turkish Thoracic Society Experts Consensus Report: Recommendations for Pulmonary Function Tests During and After COVID 19 Pandemic.

Turk Thorac J 2020 May;21(3):193-200

Department of Pulmonary Diseases, Ankara University School of Medicine, Ankara Turkey.

The recommendation of conducting pulmonary function tests (PFTs) from different societies during and after the coronavirus disease (COVID-19) pandemic was rated by the experts of the Turkish Thoracic Society (TTS) and presented as the TTS experts consensus report. Information about the topic has been provided.Globally, as of mid-May 2020, there have been over 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/TurkThoracJ.2020.20107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311158PMC

Alternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective.

Front Bioeng Biotechnol 2020 3;8:549. Epub 2020 Jun 3.

Laboratory for Biological Characterisation of Advanced Materials (LBCAM), Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, The University of Dublin, Dublin, Ireland.

When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation. Inhalation is a major exposure route for humans, and the respiratory epithelium is the first tissue that inhaled substances directly interact with. Acute inhalation toxicity testing for regulatory purposes is currently performed only in rats and/or mice according to OECD TG403, TG436, and TG433 test guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fbioe.2020.00549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284111PMC

A case of torsades de pointes induced by the third-generation EGFR-TKI, osimertinib combined with moxifloxacin.

BMC Pulm Med 2020 Jun 24;20(1):181. Epub 2020 Jun 24.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.

Background: Torsade de pointes (TdP) is a malignant arrhythmia that can be induced by QT internal prolongation due to a variety of factors. Here we report an elderly patient with advanced non-small cell lung cancer (NSCLC) had sudden TdP during hospitalization, which was caused by multiple factors such as osimertinib, moxifloxacin and patient self-factors.

Case Presentation: An 85-year-old man with advanced NSCLC with brain andbone metastasis was initially treated with gefitinib targeted therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01217-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313192PMC

FACTORS ASSOCIATED TO QUALITY OF LIFE IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS.

Rev Paul Pediatr 2020 19;38:e2018397. Epub 2020 Jun 19.

Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Rio de Janeiro, RJ, Brasil.

Objective: To verify the association between quality of life, functional capacity and clinical and nutritional status in children and adolescents with cystic fibrosis (CF).

Methods: Cross-sectional study, including patients from eight to 18 years old with CF. Quality of life, functional capacity, nutritional status and clinical status were evaluated with the Cystic Fibrosis Questionnaire; the 6-minute walk test (6MWT) and manual gripping force (MGF); the height percentiles for age and body mass index for age and respiratory function test, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1984-0462/2020/38/2018397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307721PMC

Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea.

Pulm Circ 2020 Jul-Sep;10(3). Epub 2020 Jun 11.

DRK Kliniken Berlin, Department Cardiology, Berlin, Germany.

This prospective study compared exercise test and intravenous fluid challenge in a single right heart catheter procedure to detect latent diastolic heart failure in patients with echocardiographic heart failure with preserved ejection function. We included 49 patients (73% female) with heart failure with preserved ejection function and pulmonary artery wedge pressure ≤15 mmHg. A subgroup of 26 patients had precapillary pulmonary hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2045894020917887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290273PMC

Can Pulmonary Function Testing Predict the Functional Outcomes of Post-stroke Patients? An Observational Study.

Am J Phys Med Rehabil 2020 Jun 22. Epub 2020 Jun 22.

Department of Rehabilitation Medicine, Bundang Jesaeng General Hospital, 20, Seohyeon-ro 180 beon-gil, Bundang-gu, Seoungnam-si 13590, Gyeonggi-do, Republic of Korea.

Objective: Patients with stroke may experience pulmonary dysfunction that reduces movement of the muscles involved in postural control and respiration. This study aimed to evaluate the relationship between postural control and respiratory muscle strength using pulmonary function testing. We sought to identify the respiratory function parameters that predict the functional outcomes patients with stroke at discharge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PHM.0000000000001507DOI Listing

Pre-capillary pulmonary hypertension in elderly patients: a descriptive study.

Geriatr Psychol Neuropsychiatr Vieil 2020 Jun 23. Epub 2020 Jun 23.

Département de médecine interne, Hôpital civil, Clinique médicale B, Hôpitaux universitaires de Strasbourg, France.

Introduction: Pulmonary hypertension (PH) is a serious medical condition subsequently complicating many other common diseases. PH seems to be increasing in the elderly; however, it has been poorly studied in this group. The aim of this study was to determine the diagnostic and prognosis features as well as management of pre-capillary PH in the elderly compared to young subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/pnv.2020.0849DOI Listing

Lung clearance index-triggered intervention in children with cystic fibrosis - A randomised pilot study.

J Cyst Fibros 2020 Jun 20. Epub 2020 Jun 20.

CF Centre Copenhagen, Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark. Electronic address:

Hypothesis: Using increase in the lung clearance index (LCI) as a trigger for bronchoalveolar lavage (BAL) and associated antimicrobial treatment might benefit clinical outcomes in children with cystic fibrosis (CF).

Methods: A 2-year, longitudinal, interventional, randomized, controlled pilot study with quarterly visits in 5-18 years old children with CF. LCI and z-scores for the forced expired volume in 1 s (zFEV) and body mass index (zBMI) were obtained at every visit, CF Questionnaire-revised (CFQ-R) yearly and BAL and chest computed tomography at first and last visit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2020.06.010DOI Listing

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation.

Cell Commun Signal 2020 Jun 23;18(1):98. Epub 2020 Jun 23.

Department of Respiratory and Critical Care Medicine, Yangpu Hospital, Tongji Universtiy School Of Medicine, Shanghai, China.

Background And Purpose: Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal. It is important to exploit new potential of molecularly targeted therapies. High-frequency somatic mutations in KEAP1/NRF2 (27. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00568-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310414PMC
June 2020
3.378 Impact Factor

Will the COVID-19 pandemic decrease the FatMax?

J Appl Physiol (1985) 2020 07;129(1)

Université Clermont Auvergne, CNRS, INSERM, GReD, Translational Approach to Epithelial Injury and Repair, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Ophthalmology, Clermont-Ferrand, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00380.2020DOI Listing

Hyperbaric oxygen therapy may be effective to improve hypoxemia in patients with severe COVID-2019 pneumonia: two case reports.

Undersea Hyperb Med 2020 Second Quarter;47(2):181-187

Department of Neurosurgery, Changhai Hospital, Navy Military Medical University, Shanghai China.

Objectives: To determine whether hyperbaric oxygen (HBO2) therapy be effective to improve hypoxemia for severe COVID-19 pneumonia patients.

Methods: Two male patients ages 57 and 64 years old were treated. Each met at least one of the following criteria: shortness of breath; respiratory rate (RR) ≥30 breaths/minute; finger pulse oxygen saturation (SpO2) ≤93% at rest; and oxygen index (P/F ratio: PaO2/FiO2 ≤300 mmHg). Read More

View Article

Download full-text PDF

Source

Hyperbaric oxygen as a treatment for COVID-19 infection?

Undersea Hyperb Med 2020 Second Quarter;47(2):177-179

Medical Director and Division Chief, Hyperbaric Medicine, University of Utah School of Medicine, LDS Hospital, Salt Lake City, UtahU.S.

Recently the internet has been abuzz with new ideas to treat COVID-19, including hyperbaric oxygen (HBO2) therapy, undoubtedly driven by the fact that until recently there have been few therapeutic options for this highly contagious and often lethal infection. . . Read More

View Article

Download full-text PDF

Source

Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score.

PLoS One 2020 23;15(6):e0234972. Epub 2020 Jun 23.

Department Rheumatology, University Hospital of Nancy, Nancy, France.

Objective: To evaluate prevalence of structural lesions, synovitis and bone marrow lesions (BMLs) on MRI performed with a 0.3T imaging system in patients with erosive hand osteoarthritis (EHOA) and to compare them to the anatomic radiographic Verbruggen-Veys score (VV).

Design: For this Cross-sectional study, fifty-five EHOA patients were studied with 0. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234972PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310719PMC

Quality of life was similar in children with congenital diaphragmatic hernia and oesophageal atresia and related to respiratory morbidity.

Acta Paediatr 2020 Jun 21. Epub 2020 Jun 21.

Univ. Lille, CHU Lille, Paediatric Pulmonology and Allergy Unit, Hôpital Jeanne de Flandre, F-59000, Lille, France.

Aim: To assess quality of life (QoL) in children with congenital diaphragmatic hernia (CDH) and to compare it with oesophageal atresia (OA).

Methods: A cross-sectional study in CDH children (≥ 7 years) was conducted in Lille University Hospital, France, from January 2013 to April 2014. History, lung function (rest, exercise), Pediatric Quality of Life Inventory questionnaires (PedsQoL 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15426DOI Listing

Exploration and correlation analysis of changes in Krebs von den Lungen-6 levels in COVID-19 patients with different types in China.

Biosci Trends 2020 Jun 21. Epub 2020 Jun 21.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

This study aimed to determine the clinical significance of Krebs von den Lungen-6 (KL-6) in patients with COVID-19, so as to find a marker with high sensitivity, specificity and easy detection to evaluate the lung injury and inflammation of COVID-19. Sixty-three COVID-19 patients and 43 non-COVID-19 patients with similar clinical phenotypes and/or imaging findings were enrolled to test the levels of KL-6 using chemiluminescent immunoassay. In addition, the blood gas, imaging and lymphocyte factors tests were collected from all participants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5582/bst.2020.03197DOI Listing

Artificial Stone Silicosis: Rapid Progression Following Exposure Cessation.

Chest 2020 Jun 2. Epub 2020 Jun 2.

Public Health Service, Regional Directorate of the Department of Health and Families of Andalusia in Cádiz, Cádiz, Spain.

Background: Silicosis is rapidly emerging in high-income countries in relation to the replacement of natural stone with artificial stone, especially in the manufacturing and installation of kitchen and bathroom countertops. Progression of this form of silicosis following the cessation of exposure is unknown.

Research Question: The objective of this study was to determine the radiologic progression and lung function in individuals with artificial stone silicosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2020.03.026DOI Listing

Retrospective evaluation of childhood paraphenylenediamine intoxication due to black henna.

Turk J Pediatr 2020 ;62(3):387-393

Department of Pediatrics, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Background And Objectives: Paraphenylenediamine (PPD) is a toxic substance in henna. Oral intake of this substance causes severe systemic toxicity. To the best of our knowledge there are no studies in the literature conducted only on children exposed to henna intoxication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24953/turkjped.2020.03.005DOI Listing
January 2020

[Autopneumonectomie. A Forgotten Disease].

Pneumologie 2020 Jun 17;74(6):371-373. Epub 2020 Jun 17.

Abteilung für Kardiologie, Rhythmologie und konservative Intensivmedizin, Augusta-Krankenhaus Düsseldorf, Akademisches Lehrkrankenhaus der Heinrich-Heine-Universität Düsseldorf.

History:  An 80-year old female was referred to our hospital with left internal carotid artery stenosis and a childhood history of hemoptysis.

Investigations And Diagnosis:  The ECG showed 2nd degree Mobitz atrio-ventricular block. The chest x-ray and computerized tomography identified a shift of the mediastinum and the heart to the left. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1148-8770DOI Listing

Association between sleep disordered breathing, neurocognitive impairment and diastolic function in acute heart failure patients: an insight after the vulnerable phase of the hospitalization.

Intern Emerg Med 2020 Jun 15. Epub 2020 Jun 15.

Cardiovascular Department, ASST Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.

Sleep disordered breathing (SDB) and neurocognitive impairment (NI) are a typical feature of HF (heart failure), especially with preserved ejection fraction (HFpEF). So far, very few data exist regarding changes in the severity of SDB, the degree of NI, and the diastolic function in acute HF (AHF) patients and during follow up. In a population of 24 AHF patients (12 with reduced ejection fraction-HFrEF- and 12 HFpEF) with SDB a complete echocardiogram, a set of NI tests, and a polysomnography were performed in the acute phase and after 90 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11739-020-02397-xDOI Listing

Obesity: how pulmonary function tests may let us down.

J Bras Pneumol 2020 Jun 15;46(3):e20200116. Epub 2020 Jun 15.

. Pulmonary Function Laboratory and Respiratory Investigation Unit, Division of Respirology and Sleep Medicine, Kingston Health Science Center & Queen's University, Kingston (ON) Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.36416/1806-3756/e20200116DOI Listing

Tracking disease progression in COPD with pulmonary function tests.

Int J Tuberc Lung Dis 2020 Jun;24(6):553-555

Respiratory Physiology Unit, Department of Respiratory Medicine, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université de Paris, Paris, France, , Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/ijtld.20.0269DOI Listing

Serology-positive but minimally symptomatic COVID-19 may still cause lung injury and lung function impairment.

Int J Tuberc Lung Dis 2020 Jun;24(6):568-569

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/ijtld.20.0197DOI Listing