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Biol Res Nurs 2022 Jun 27:10998004221109925. Epub 2022 Jun 27.

Division of Pulmonary, Critical Care and Sleep Medicine, 205280University of Washington, Seattle, WA, USA.

: Survivors of acute respiratory failure (ARF) experience long-term cognitive impairment and circadian rhythm disturbance after hospital discharge. Although prior studies in aging and neurodegenerative diseases indicate actigraphy-estimated rest-activity circadian rhythm disturbances are risk factors for cognitive impairment, it is unclear if this applies to ARF survivors. This study explored the relationships of actigraphy-estimated rest-activity circadian rhythms with cognitive functioning in ARF survivors at 3 months after discharge. Read More

Front Nutr 2022 9;9:884104. Epub 2022 Jun 9.

Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Background: Children with cystic fibrosis (CF) are expected to have suboptimal serum vitamin D status and altered gut microbiota. The altered gut microbiota is hypothesized to have a pro-inflammatory effect that further complicates the existing respiratory inflammation. Emerging evidence suggests an association between vitamin D and gut microbiota. Read More

Respir Med Case Rep 2022 13;38:101685. Epub 2022 Jun 13.

Department of Respiratory Medicine, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjuku-Ku, Tokyo, 162-8655, Japan.

Bronchial thermoplasty (BT) is a type of bronchoscopic treatment specifically used for patients with severe asthma. Most severe asthmatics receive systemic steroids and are at risk of being immunocompromised. This raises the clinical question of whether or not BT can be effectively and safely performed in such patients. Read More

Transpl Int 2022 9;35:10546. Epub 2022 Jun 9.

Department of Medical Sciences, University of Turin, Turin, Italy.

Despite advances in immunosuppression therapy, acute rejection remains the leading cause of graft dysfunction in lung transplant recipients. Donor-derived cell-free DNA is increasingly being considered as a valuable biomarker of acute rejection in several solid organ transplants. We present a technically improved molecular method based on digital PCR that targets the mismatch between the recipient and donor at the locus. Read More

BMC Pulm Med 2022 Jun 25;22(1):249. Epub 2022 Jun 25.

Department of Pulmonary Function Test, School of Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, China.

Background And Objective: End-tidal PCO (PetCO) patterns during exercise testing as well as ventilatory equivalents for CO have been reported for different pulmonary vascular diseases but seldomly for the significant differences in exercise response depending on the etiology of pulmonary hypertension. We aimed to compare PetCO change pattern in IPAH and CTEPH with varying severity during incremental cardiopulmonary exercise testing (CPET).

Methods: 164 IPAH patients and 135 CTEPH patients referred to Shanghai Pulmonary Hospital between 2012 and 2019 were retrospectively recruited into the study. Read More

Lung 2022 Jun 25. Epub 2022 Jun 25.

Department of Radiology, University of Florida, Gainesville, FL, USA.

Quantitative computed tomography (QCT) has recently gained an important role in the functional assessment of chronic lung disease. Its capacity in diagnostic, staging, and prognostic evaluation in this setting is similar to that of traditional pulmonary function testing. Furthermore, it can demonstrate lung injury before the alteration of pulmonary function test parameters, and it enables the classification of disease phenotypes, contributing to the customization of therapy and performance of comparative studies without the intra- and inter-observer variation that occurs with qualitative analysis. Read More

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Respiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon, UK.

A man in his 70s presents with 12 months of progressive dyspnoea, sicca symptoms and Raynaud's phenomenon. Serological testing and tear duct biopsy confirm Sjögren's syndrome (SS). Bilateral nodular-cystic appearances highly suggestive of lymphoid interstitial pneumonia (LIP) are noted on high-resolution computed tomography (HRCT), supported by a 40% lymphocytosis on bronchoalveolar lavage. Read More

Laryngoscope 2022 Jun 24. Epub 2022 Jun 24.

Department of Otolaryngology-Head & Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.

Objective: We aimed to assess the relationship between patient-performed and patient-reported peak flow meter (PFM) measurements with pulmonary function testing (PFT) and Dyspnea Index (DI) scores as a tool for monitoring Subglottic stenosis (SGS) disease progression remotely.

Methods: Thirty-five SGS patients were prospectively enrolled. Patients were given PFMs to report serial measurements from home. Read More

Front Biosci (Landmark Ed) 2022 Jun;27(6):178

Department of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, 155, 00161 Rome, Italy.

Background: Coronavirus pandemic has influenced our society with social distancing and management of chronic disease such as cystic fibrosis (CF). During the Italian lockdown from March to May 2020, CF patients reduced the number of outpatient visits, limited social interactions and spent more time at home. The aim of this study is to evaluate the impact of the lockdown on body mass index (BMI) and lung function tests on CF patients. Read More

Front Biosci (Landmark Ed) 2022 May;27(6):168

University Children's Hospital Bonn, 53127 Bonn, Germany.

Background: Recently, we provided evidence that a single nucleotide polymorphism (SNP), rs41266431, on the gap junction protein alpha 4 (GJA4) gene, acts as a modifier for clinical disease severity in patients with cystic fibrosis (CF). These features are very similar to those of variants of the mannose-binding lectin (MBL). This study aimed to clarify whether the clinical disease phenotype associated with GJA4 variants is independent of MBL variants. Read More

Medicina (Kaunas) 2022 Jun 16;58(6). Epub 2022 Jun 16.

Medical I Department, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

: Functional capacity (FC) assessed via cardiopulmonary exercise testing (CPET) is a novel, independent prognostic marker for patients with coronary artery disease (CAD). Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are two readily available predictors of systemic inflammation and cardiovascular event risk, which could be used as cost-effective predictors of poor FC. The purpose of this study was to evaluate the utility of NLR and PLR in predicting poor FC in patients with CAD and recent elective percutaneous coronary intervention (PCI). Read More

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

School of Public Health, Fudan University, Shanghai 200032, China.

Physical fitness measures overall physical health. It is the ability of the body to work effectively and stay healthy during leisure and emergencies. Given the progressive integration of 2-3-year-olds into preschool, physical fitness testing of these children has become increasingly important. Read More

Int J Environ Res Public Health 2022 Jun 19;19(12). Epub 2022 Jun 19.

Center for Liberal Arts, Fukuoka Institute of Technology, Fukuoka 811-0295, Japan.

This study aimed to compare the degree of exhaustion and trophic effects between continuous exercise (CE) and intermittent exercise (IE) at lactate threshold (LT) intensity. Seven healthy men (age: 43-69 years) performed the following three experimental tests in a randomized crossover order: (1) control; (2) CE, performed as a 20-min of cycling at LT intensity; and (3) IE, performed as 20 sets of a one-min bout of cycling at LT intensity with a 30-s rest between every two sets. Heart rate (HR), blood lactate concentration (LA), rating of perceived exertion (RPE), catecholamines, cortisol, growth hormone, insulin-like growth factor (IGF)-1, and brain-derived neurotrophic factor (BDNF) were measured. Read More

Int J Environ Res Public Health 2022 Jun 17;19(12). Epub 2022 Jun 17.

Research Group for Occupational and Environmental Medicine, Department of Global Public and Primary Care, University of Bergen, 5020 Bergen, Norway.

Background: Pesticide use in Ethiopia has become a common practice in which large-scale flower farms are the main consumers. Workers on flower farms might be exposed to pesticides while spraying or while performing other tasks related to pesticide use and management. It is unclear whether working as a flower farm sprayer is associated with respiratory health problems. Read More

Int J Environ Res Public Health 2022 Jun 16;19(12). Epub 2022 Jun 16.

Dipartimento di Scienze Motorie e del Benessere, Università degli Studi di Napoli Parthenope, 80133 Naples, Italy.

Background: Physical fitness (PF) levels correlate with health hallmarks at all ages. In this study, w aimed to determine the PF level of schoolchildren from the Campania Region (Italy) through health-related PF (HRPF) components, taking into account body weight and sport practice (SP).

Methods: PF level was determined in 565 schoolchildren aged 10-13 (11. Read More

Int J Environ Res Public Health 2022 Jun 16;19(12). Epub 2022 Jun 16.

Applied Sports Technology Exercise and Medicine Research Centre (A-STEM), Swansea University, Swansea SA1 8EN, UK.

Whilst participation in regular exercise and sport has generally increased over recent decades globally, fundamental questions remain regarding the influence of growth, maturation, and sex on the magnitude of training response throughout adolescence. Trained (108 participants, 43 girls; age: 14.3 ± 1. Read More

Int J Environ Res Public Health 2022 Jun 10;19(12). Epub 2022 Jun 10.

Institute of Health Sciences, Collegium Medicum, Jan Kochanowski University, 5 Żeromskiego Str., 25-369 Kielce, Poland.

The data regarding somatic and physiological effects of sport-related physical activities in youth are limited. Moreover, whether exercise training is capable of increasing cardio-respiratory fitness remains a disputable issue. The study undertook to assess the effect of swimming training on cardio-respiratory fitness (CRF) and the development of physical traits in prepubertal boys, and to determine which of the traits is the best predictor of their CRF. Read More

Int J Environ Res Public Health 2022 Jun 7;19(12). Epub 2022 Jun 7.

Department of Health Science, Wuhan Sports University, Wuhan 430079, China.

The occurrence of sports injury has been proven to be highly associated with injury history. (1) Background: This study aimed to validate the feasibility and effectiveness of the Functional Movement Screen (FMS) as a predictor of sports injury risk for Chinese police staff by exploring the optimal cut-off value of the FMS total score for the identification of previous injury. (2) Methods: More than 160 Chinese police staff were recruited and completed the FMS and interviews. Read More

Healthcare (Basel) 2022 Jun 17;10(6). Epub 2022 Jun 17.

Centre Hospitalier Universitaire (CHU) de Bordeaux, Pediatrics Department, Pediatric Pulmonology, CEDEX, 33076 Bordeaux, France.

Background: The ability to perceive bronchial obstruction is variable in asthma. This is one of the main causes of inaccurate asthma control assessment, on which therapeutic strategies are based.

Objective: Primary: To evaluate the ability of physicians to characterize the bronchial obstruction perception profile in asthmatic children using a clinical and spiro-metric telemonitoring device. Read More

Diagnostics (Basel) 2022 Jun 20;12(6). Epub 2022 Jun 20.

Department of Medicine and Surgery, Section of Radiology, University of Parma, Maggiore Hospital, Via Gramsci 14, 43125 Parma, Italy.

Background: Chest Computed Tomography (CT) imaging has played a central role in the diagnosis of interstitial pneumonia in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can be used to obtain the extent of lung involvement in COVID-19 pneumonia patients either qualitatively, via visual inspection, or quantitatively, via AI-based software. This study aims to compare the qualitative/quantitative pathological lung extension data on COVID-19 patients. Secondly, the quantitative data obtained were compared to verify their concordance since they were derived from three different lung segmentation software. Read More

Diagnostics (Basel) 2022 Jun 10;12(6). Epub 2022 Jun 10.

National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Williams-Beuren syndrome (WS) results from the deletion of 25-27 coding genes, including elastin (), on human chromosome 7q11.23. Elastin provides recoil to tissues; emphysema and chronic obstructive pulmonary disease have been linked to its destruction. Read More

Biomedicines 2022 Jun 19;10(6). Epub 2022 Jun 19.

Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.

Sensitization to fungal allergens is one of the proposed phenotypes in asthma. An association between fungal sensitization and worse clinical outcomes is apparent. Moreover, fungal sensitization in asthma that is associated with different type of immunological mechanism has been reported. Read More

Sci Rep 2022 Jun 23;12(1):10633. Epub 2022 Jun 23.

Department of Motor Performance, Faculty of Physical Education and Mountain Sports, Transilvania University of Braşov, 500068, Braşov, Romania.

The present study aimed to determine the influence of force-power-velocity, vertical and horizontal jumps, and repeated sprint ability on the sprinting performance of adult women soccer players. Eighteen women soccer players from one team participating in the first female national Spanish soccer league were analyzed. Fitness assessments were performed twice in a period of three months. Read More

Sci Rep 2022 Jun 23;12(1):10607. Epub 2022 Jun 23.

Department of Environmental Health, Harvard University T.H Chan School of Public Health, Boston, MA, USA.

There are knowledge gaps regarding healthy lifestyle (HLS) interventions in fire academy settings and also concerning the impacts of the pandemic on training. We enrolled fire recruits from two fire academies (A and B) in New England in early 2019 as the historical control group, and recruits from academies in New England (B) and Florida (C), respectively, during the pandemic as the intervention group. The three academies have similar training environments and curricula. Read More

JAMA Netw Open 2022 Jun 1;5(6):e2218367. Epub 2022 Jun 1.

Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Metabolites 2022 Jun 18;12(6). Epub 2022 Jun 18.

Department of Kinesiology, University of Texas at San Antonio, San Antonio, TX 78249, USA.

Cardiac mitochondrial dysfunction contributes to obesity-associated heart disease. Maternal and postnatal diet plays an important role in cardiac function, yet the impacts of a mismatch between prenatal and postweaning diet on cardiometabolic function are not well understood. We tested the hypothesis that switching to a standard chow diet after weaning would attenuate systemic metabolic disorders and cardiac and mitochondrial dysfunction associated with maternal and postnatal high-fat/high-sucrose (HFHS) diet in mice. Read More

Andes Pediatr 2022 Apr;93(2):281

Escuela de Kinesiología, Universidad de Valparaíso, Valparaíso, Chile.

Andes Pediatr 2022 Apr;93(2):279-280

Facultad de Salud, Universidad del Desarrollo, Santiago, Chile.

ERJ Open Res 2022 Apr 13;8(2). Epub 2022 Jun 13.

Dept of Respiratory Medicine, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium.

Background: Over the past decade, the Global Lung Function Initiative (GLI) Network has published all-age reference equations on spirometry, diffusing capacity of the lung for carbon monoxide ( ) and lung volumes.

Methods: We evaluated the appropriateness of these equations in an adult Caucasian population. Retrospective lung function data on subjects who performed tests prior to a diagnostic sleep investigation were analysed. Read More

Surg Endosc 2022 Jun 22. Epub 2022 Jun 22.

Esophagogastric Surgery Unit, Haut Lévêque Hospital, CHU Bordeaux, Bordeaux, France.

Background: Dyspnoea in patients with a para-oesophageal hernia (PEH) occurs in 7% to 32% of cases and is very disabling, especially in elderly patients, and its origin is not well defined. The present study aims to assess the impact of PEH repair on dyspnoea and respiratory function.

Methods: From January 2019 to May 2021, all consecutive patients scheduled for PEH repair presenting with a modified Medical Research Council (mMRC) score ≥ 2 for dyspnoea were included. Read More