52,869 results match your criteria Pulmonary Embolism


Factor XIII Prevents Pulmonary Emboli in Mice by Stabilizing Deep Vein Thrombi.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

Background:  Deep vein thrombosis (DVT) can lead to pulmonary embolism (PE), but the mechanisms responsible for this progression are unknown. Previously, we showed that inhibition of thrombin-mediated activation of factor (F) XIII promotes venous thrombus stability in a murine model.

Aim:  In this study, we investigate the consequence of attenuating fibrinolysis, using FXIII, α-antiplasmin (α-AP) or ε-aminocaproic acid (EACA) supplementation, on clot lysis and venous thrombus stability using the same mouse model. Read More

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http://dx.doi.org/10.1055/s-0039-1685141DOI Listing
April 2019
1 Read

Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury.

J Surg Res 2019 Apr 17;241:24-30. Epub 2019 Apr 17.

Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: Pulmonary air embolism (PAE)-induced acute lung injury (ALI) can be caused by massive air entry into the lung circulation. PAE can occur during diving, aviation, and some iatrogenic invasive procedures. PAE-induced ALI presents with severe inflammation, hypoxia, and pulmonary hypertension, and it is a serious complication resulting in significant morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.028DOI Listing
April 2019
1 Read

Gender Differences for Hip and Knee Arthroplasty: Complications and Healthcare Utilization.

J Arthroplasty 2019 Apr 1. Epub 2019 Apr 1.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.

Introduction: The influence of patient gender on complications and healthcare utilization remains unexplored. The purpose of the present study was to determine if patient gender significantly affected outcomes following total hip arthroplasty (THA) and total knee arthroplasty (TKA).

Methods: Retrospective cohort study of THA and TKA patients was performed using the Nationwide Inpatient Sample from 2002 to 2011. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08835403193032
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http://dx.doi.org/10.1016/j.arth.2019.03.064DOI Listing
April 2019
1 Read

[Intracardiac and Pulmonary Cement Embolism after Percutaneous Vertebroplasty].

Kardiologiia 2019 Apr 18;59(4):92-96. Epub 2019 Apr 18.

Central Clinical Hospital of the Management Affair of President RF, Moscow.

The article presents a clinical case of embolism with bone cement of the right ventricle of the heart and pulmonary artery after percutaneous vertebroplasty in a patient aged 63 years. According to the results of a comprehensive examination using ultrasound and x-ray methods, three foreign bodies were found: in the right ventricle cavity, in the trunk of the pulmonary artery, in the branches of the left pulmonary artery. Considering the stable condition, normal blood oxygen saturation, the lack of influence of formations on intracardiac hemodynamics, it was decided to refrain from surgery, since the risk of intervention exceeded the possible benefit. Read More

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http://dx.doi.org/10.18087/cardio.2019.4.10255DOI Listing

Identifying chronic thromboembolic pulmonary hypertension through the French national hospital discharge database.

PLoS One 2019 18;14(4):e0214649. Epub 2019 Apr 18.

Bayer AG, Berlin, Germany.

Chronic thromboembolic pulmonary hypertension (CTEPH), a rare pulmonary vascular disease, is often misdiagnosed due to nonspecific symptoms. The objective of the study was to develop, refine and validate a case ascertainment algorithm to identify CTEPH patients within the French exhaustive hospital discharge database (PMSI), and to use it to estimate the annual number of hospitalized patients with CTEPH in France in 2015, as a proxy for disease prevalence. As ICD-10 coding specifically for CTEPH was not available at the time of the study, a case ascertainment algorithm was developed in close collaboration with an expert committee, using a two-step process (refinement and validation), based on matched data from PMSI and hospital medical records from 2 centres. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214649PLOS
April 2019
1 Read

Influence of Age, Gender and Body Mass Index on the Thickness of the Gluteal Subcutaneous Fat - Implications for Safe Buttock Augmentation Procedures.

Plast Reconstr Surg 2019 Apr 9. Epub 2019 Apr 9.

Department of Medical Education, Albany Medical College, Albany, NY, USA.

Objective: The deep intramuscular approach during buttock augmentation with fat grafting has been associated with a significantly increased risk for pulmonary fat embolism. This study was designed to provide guidance for the injection into the subcutaneous fat i.e. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005707DOI Listing
April 2019
1 Read

Mediastinal emphysema after long-distance flight with ketoacidosis and underlying diabetes mellitus type 1.

Respirol Case Rep 2019 Jul 5;7(5):e00423. Epub 2019 Apr 5.

Department of Radiology Charité Universitätsmedizin Berlin Berlin Germany.

A 21-year old female with diabetes mellitus type 1 presented to our hospital's emergency department having suffered from shortness of breath, mild chest pain, and vomiting following her arrival after a long-distance flight two days earlier. Symptoms had since subsided and physical examination was normal. Blood analysis revealed increased D-dimers and diabetic ketoacidosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rcr2.423
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http://dx.doi.org/10.1002/rcr2.423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451023PMC
July 2019
2 Reads

Is thrombotic event a side effect of oral buprenorphine abuse? Two case reports.

Clin Case Rep 2019 Apr 3;7(4):740-743. Epub 2019 Mar 3.

Cardiology Department of Shohaday-e-Tajrish Hospital Shahid Beheshti University of Medical Sciences (SBMU) Tehran Iran.

Buprenorphine is used to treat opioid addiction. The spectrum of complications of oral buprenorphine is not well known. We describe two cases and based on a hypothesis is proposed which suggests that the use of oral buprenorphine could be relevant to the increase of thrombotic risk. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2086
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http://dx.doi.org/10.1002/ccr3.2086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452464PMC
April 2019
1 Read

Popliteal Vein Aneurysm Associated with Varicose Veins, Hydrocele, and Multiple Congenital Osteomas: A Case Report and Review of the Literature.

Vasc Specialist Int 2019 Mar;35(1):44-47

Department of Vascular Surgery, Nasser Institute for Research and Treatment, Cairo, Egypt.

Popliteal vein aneurysms (PVAs) represent a rare form of venous aneurysms and necessitate prompt management because of their well-established risk of pulmonary embolism (PE). Herein, we report a rare case of PVA without PE, successfully treated with open surgical repair. A 27-year-old man presented to our vascular clinic with chronic pain and swelling in his left lower limb. Read More

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http://dx.doi.org/10.5758/vsi.2019.35.1.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453596PMC

Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism.

Dis Markers 2019 12;2019:2324515. Epub 2019 Mar 12.

Department of Cardiology, Shanghai Tenth People's Hospital, Shanghai 200072, China.

Objective: To investigate the value of the PTX-3 test in evaluating the prognosis of acute pulmonary embolism (APE).

Method: 117 APE patients were selected and divided into two groups according to plasma PTX-3 levels, including the group in which PTX - 3 ≥ 3.0 ng/mL ( = 42) and the group in which PTX - 3 < 3. Read More

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http://dx.doi.org/10.1155/2019/2324515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434296PMC

Case Report: Unprovoked venous thromboembolism in a young adult male.

F1000Res 2019 14;8:182. Epub 2019 Feb 14.

Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

A 24-year-old male was presented to us with sudden onset of chest pain and dyspnea for the past one hour. There was no history of calf pain, trauma, surgery, prolonged immobilization, long-haul air travel, bleeding diathesis or any other co-morbidity. The patient denied any addiction history. Read More

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https://f1000research.com/articles/8-182/v1
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http://dx.doi.org/10.12688/f1000research.18202.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446494PMC
February 2019
4 Reads

Venous thromboembolic and bleeding complications among pregnant women with Klippel-Trenaunay syndrome.

J Am Acad Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Klippel-Trenaunay Syndrome (KTS) is a vascular malformation overgrowth syndrome characterized by capillary malformation, venous malformation and limb overgrowth, +/- lymphatic malformation. Patients are at an increased risk of hemorrhage and venous thromboembolism (VTE). Consequently, women with this condition often are counseled to avoid pregnancy, but there is minimal data available on the relationship between pregnancy, VTE and bleeding risk. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.018DOI Listing
April 2019
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Acquired Systemic-to-Pulmonary Artery Transpleural Collateral Vessel Secondary to Pulmonary Embolism.

Radiology 2019 Apr 16:190175. Epub 2019 Apr 16.

From the Department of Radiology, Service de Radiologie A, Groupe Hospitalier Cochin Broca Hotel-Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France.

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http://dx.doi.org/10.1148/radiol.2019190175DOI Listing
April 2019
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Venous thromboprophylaxis after total hip arthroplasty: aspirin, warfarin, enoxaparin, or factor Xa inhibitors?

Hip Int 2019 Apr 16:1120700019841600. Epub 2019 Apr 16.

Department of Orthopaedic Surgery, Stanford Hospital and Clinics, Redwood City, CA, USA.

Introduction: Debate over the ideal agent for venous thromboembolism (VTE) prophylaxis after total hip arthroplasty (THA) has led to changes in prescribing trends of commonly used agents. We investigate variation in utilisation and the differences in VTE incidence and bleeding risk in primary THA after administration of aspirin, warfarin, enoxaparin, or factor Xa inhibitors.

Methods: 8829 patients were age/sex matched from a large database of primary THAs performed between 2007 and 2016. Read More

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http://dx.doi.org/10.1177/1120700019841600DOI Listing
April 2019
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Safety and effectiveness of aspirin and enoxaparin for venous thromboembolism prophylaxis after total hip and knee arthroplasty: a systematic review.

ANZ J Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Background: Patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) are at risk of venous thromboembolism (VTE). Australian orthopaedic guidelines recommend aspirin and low-molecular-weight heparin (e.g. Read More

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http://dx.doi.org/10.1111/ans.15122DOI Listing
April 2019
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Importance of accurate respiratory rate for triage of suspected pulmonary embolism.

Authors:
Oscar M P Jolobe

QJM 2019 Apr 15. Epub 2019 Apr 15.

Medical Division Manchester Medical Society, Simon Building, Brunswick Street, Manchester.

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http://dx.doi.org/10.1093/qjmed/hcz084DOI Listing
April 2019
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Oxygen Venous Embolism After Hydrogen Peroxide Use During Percutaneous Nephrolithotomy.

J Endourol Case Rep 2019 18;5(1):25-27. Epub 2019 Mar 18.

Department of Urology, George Washington University Medical School, Washington, District of Columbia.

Hydrogen peroxide (HO) is a common antiseptic that is available without a prescription in the United States, and it is indicated for minor dermal abrasion; mouth, gum, or dental irritations; and removal of oral secretion. Several other medical uses have also been described, including clot dissolution during endoscopic gastrointestinal evaluation, cleansing of orthopedic surgical sites, and bladder irrigation. However, these uses of HO, as well as high-dose ingestion, have been associated with a wide variety of medical complications, including but not limited to air pulmonary embolism and stroke. Read More

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https://www.liebertpub.com/doi/10.1089/cren.2018.0111
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http://dx.doi.org/10.1089/cren.2018.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461058PMC
March 2019
2 Reads

Stroke and thromboembolic events in men with prostate cancer treated with definitive radiation therapy with or without androgen deprivation therapy.

Prostate Cancer Prostatic Dis 2019 Apr 15. Epub 2019 Apr 15.

VA San Diego Health Care System, La Jolla, CA, USA.

Background: There is conflicting evidence regarding the association between androgen deprivation therapy (ADT) for prostate cancer (PC) and the risk of developing stroke and thromboembolic events. Our study evaluated the association between ADT use and development of stroke, transient ischemic attack (TIA), deep vein thrombosis (DVT), and pulmonary embolism (PE) in a homogenous group of men with PC treated with definitive radiation therapy (RT) after controlling for multiple sources of confounding.

Methods: Observational cohort study of patients diagnosed with PC at the US Department of Veterans Affairs between 1 January 2001 and October 31, 2015 and treated with definitive RT. Read More

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http://dx.doi.org/10.1038/s41391-019-0150-5DOI Listing
April 2019
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Update in Hospital Medicine: Practical Lessons from Current Literature.

J Hosp Med 2019 Apr 8;14:E1-E5. Epub 2019 Apr 8.

Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Hospital medicine continues to grow in workforce, clinical scope, and academic inquiry. This article provides a summary of recent high-impact publications for busy clinicians who provide care to hospitalized adults.

Methods: Authors reviewed articles that were published between March 2017 and March 2018 for the Update in Hospital Medicine presentations at the 2018 Society of Hospital Medicine and Society of General Internal Medicine annual meetings. Read More

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https://www.journalofhospitalmedicine.com/jhospmed/article/1
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http://dx.doi.org/10.12788/jhm.3206DOI Listing
April 2019
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Physical activity and risk of recurrence and mortality after incident venous thromboembolism.

J Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

K.G. Jebsen - Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.

Background: Limited data exist on the relationship between physical activity and major complications after incident venous thromboembolism (VTE).

Objectives: To investigate whether physical activity was associated with risk of recurrence and mortality in VTE patients recruited from the general population.

Methods: Patients with incident VTE (n=786) derived from the Tromsø Study surveys 4-6 (1994-95, 2001-02 and 2007-08) were included, and data on physical activity was dichotomized according to the activity level reported in the survey preceding the incident VTE (inactive: <1h per week, active: ≥1h per week). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.14449
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http://dx.doi.org/10.1111/jth.14449DOI Listing
April 2019
2 Reads

Shoulder Arthroplasty for a Fracture Is Not the Same as Shoulder Arthroplasty for Osteoarthritis: Implications for a Bundled Payment Model.

J Am Acad Orthop Surg 2019 Apr 11. Epub 2019 Apr 11.

From the Department of Orthopaedics, Wexner Medical Center at The Ohio State University Columbus, OH.

Introduction: The Center for Medicare Services currently bundles all shoulder arthroplasties, total shoulder arthroplasty and reverse total shoulder arthroplasty, into one Diagnosis-Related Group on which bundled reimbursements are then further characterized. An arthroplasty performed for traumatic indications, such as fractures, may have a different postoperative course of care compared with the one being done for degenerative arthritis/osteoarthritis (OA), despite having the same Current Procedural Terminology (CPT) and Diagnosis-related Group code.

Methods: The 2012 to 2016 American College of Surgeons-National Surgical Quality Improvement Program databases were queried using CPT-23472 to retrieve records of patients undergoing total shoulder arthroplasty/reverse total shoulder arthroplasty for degenerative arthritis/OA or proximal humerus fracture. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00268DOI Listing
April 2019
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Acute Treatment of Pulmonary Embolism: Part 2.

Am J Respir Crit Care Med 2019 Apr;199(8):P15-P16

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https://www.atsjournals.org/doi/10.1164/rccm.1998P15
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http://dx.doi.org/10.1164/rccm.1998P15DOI Listing
April 2019
2 Reads

Coagulation Laboratory Testing Is Predictive of Wound Complications Following Microdiscectomy.

Global Spine J 2019 Apr 31;9(2):138-142. Epub 2018 Jul 31.

University of Utah, Salt Lake City, UT, USA.

Study Design: Retrospective review.

Objective: To determine whether abnormal preoperative testing is associated with postoperative complications in patients undergoing a microdiscectomy.

Methods: Patients undergoing a microdiscectomy between 2006 and 2013 were identified in the National Surgical Quality Improvement Program database based on appropriate current procedural terminology coding. Read More

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http://dx.doi.org/10.1177/2192568218764677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448192PMC
April 2019
2 Reads

Lifting the fog in intermediate-risk (submassive) PE: full dose, low dose, or no thrombolysis?

F1000Res 2019 25;8. Epub 2019 Mar 25.

Pulmonary Vascular Diseases Unit, Royal Papworth Hospital, Cambridge, CB23 3RE.

Acute pulmonary embolism (PE) is a disease frequently encountered in clinical practice. While the management of haemodynamically stable, low risk patients with acute PE is well established, managing intermediate disease often presents a therapeutic dilemma. In this review, we discuss the various therapeutic options available in this patient group. Read More

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https://f1000research.com/articles/8-330/v1
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http://dx.doi.org/10.12688/f1000research.17861.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436190PMC
March 2019
2 Reads

[Effectiveness analysis of three-dimensional printing assisted surgery for unstable pelvic fracture].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):455-461

Department of Orthopedics, the Fourth People's Hospital of Zigong, Zigong Sichuan, 643000, P.R.China.

Objective: To evaluate the effectiveness of three-dimensional (3D) printing assisted internal fixation for unstable pelvic fractures.

Methods: The clinical data of 28 patients with unstable pelvic fractures admitted between March 2015 and December 2017 were retrospectively analyzed. The patients were divided into two groups according to different surgical methods. Read More

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http://dx.doi.org/10.7507/1002-1892.201806045DOI Listing
April 2019
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Prediction of new onset atrial fibrillation in patients with acute pulmonary embolism: The role of sPESI Score.

Turk Kardiyol Dern Ars 2019 Apr;47(3):191-197

Department of Cardiology, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

Objective: Acute pulmonary embolism (APE) is a serious clinical situation and atrial fibrillation (AF) is the most common arrhytmia in clinical practice. The Pulmonary Embolism Severity Index (PESI) is an accepted risk stratification tool used to predict short term mortality in APE. The aim of this study was to evaluate the relationship between the PESI score and new-onset AF in patients with APE. Read More

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http://archivestsc.com/jvi.aspx?un=TKDA-78241
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http://dx.doi.org/10.5543/tkda.2018.78241DOI Listing
April 2019
2 Reads

Clinical Effectiveness of Aspirin as Multimodal Thromboprophylaxis in Primary Total Hip and Knee Arthroplasty: A Review of 6078 Cases.

J Arthroplasty 2019 Mar 13. Epub 2019 Mar 13.

Consultant Orthopaedic Surgeon, Trauma and Orthopaedics, University Hospital of Leicester NHS Trust, Leicester, UK.

Background: Venous thromboembolism is a serious complication after total hip and knee arthroplasty. There is still no consensus regarding the best mode of thromboprophylaxis after lower limb arthroplasty. The aim of this study was to ascertain the efficacy, safety profile, and rate of adverse thromboembolic events of aspirin as extended out-of-hospital pharmacological anticoagulation for elective primary total hip and knee arthroplasty patients and whether these rates were comparable with published data for low-molecular-weight heparin (LMWH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08835403193024
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http://dx.doi.org/10.1016/j.arth.2019.03.021DOI Listing
March 2019
2 Reads

Presentation and Management of Inferior Vena Cava Thrombosis.

Ann Vasc Surg 2019 Apr 27;56:17-23. Epub 2018 Oct 27.

Department of Surgery, New York University Langone Medical Center, New York, NY. Electronic address:

Background: Inferior vena cava thrombosis (IVCT), although rare, has a potential for significant morbidity and mortality. IVCT is often a result of IVC filter thrombosis, but it can also occur de novo. Although anticoagulation remains the standard of care, endovascular techniques to restore IVC patency have become key adjunctive therapies in recent years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096183084
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http://dx.doi.org/10.1016/j.avsg.2018.08.082DOI Listing
April 2019
2 Reads

Measuring functional limitations after venous thromboembolism: A call to action.

Thromb Res 2019 Apr 7;178:59-62. Epub 2019 Apr 7.

Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.

The main objectives of therapeutic trials in venous thromboembolism (VTE) are to prevent recurrent VTE, major bleeding and death. While these outcomes are indeed highly relevant, they are also rare and do not fully capture the overall functional outcome of VTE patients. Importantly, functional limitations after VTE are prevalent after both deep vein thrombosis and pulmonary embolism occurring in up to 50% of patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193018
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http://dx.doi.org/10.1016/j.thromres.2019.04.003DOI Listing
April 2019
2 Reads

Non-specific chest pain and subsequent serious cardiovascular readmissions.

Int J Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK; Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

Background: The rates of readmission for serious cardiovascular events among patients admitted with a diagnosis of non-specific chest pain are unknown.

Methods: A national retrospective cohort study in the United States was undertaken to evaluate the rates, trends and predictors of readmission for serious cardiovascular events (acute coronary syndrome (ACS), pulmonary embolism (PE) and aortic dissection (AD)) after an inpatient episode with a primary diagnosis of non-specific chest pain.

Results: Among 1,172,430 patients with an index diagnosis of non-specific chest pain between 2010 and 2014, 2. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.04.001DOI Listing
April 2019
2 Reads

Opportunities for hospitals, hospital systems and leadership to improve VTE prophylaxis.

Semin Perinatol 2019 Mar 9. Epub 2019 Mar 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6651 Main Street, Suite F420, Houston, Texas.

A sustained increase in the maternal death rate in the U.S. remains one of the most challenging issues of the twenty-first century. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193003
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http://dx.doi.org/10.1053/j.semperi.2019.03.007DOI Listing
March 2019
2 Reads

[Intrahepatic Hematoma and Pulmonary Embolism in a Young Woman with Oral Contraceptives Complicated by Type II Heparin Induced Thrombocytopenia Requiring ECMO-Therapy: a Case Report].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Apr 12;54(4):295-300. Epub 2019 Apr 12.

A 46-year-old woman on oral contraceptives developed an intrahepatic hematoma due to a benign hepatic tumor. As an incidental finding, a computed tomography showed a pulmonary embolism. Unfractionated heparin was given in a prophylactic dosing in an attempt to balance the risk of further intrahepatic bleeding with that of thrombosis. Read More

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http://dx.doi.org/10.1055/a-0643-7877DOI Listing
April 2019
1 Read

No indication for CALR mutation analysis in Irish patients presenting with deep vein thrombosis or pulmonary embolism.

Ir J Med Sci 2019 Apr 11. Epub 2019 Apr 11.

Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1007/s11845-019-02018-3DOI Listing
April 2019
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Prothrombin Complex Concentrates for Coagulopathy in Liver Disease: Single-Center, Clinical Experience in 105 Patients.

Hepatol Commun 2019 Apr 5;3(4):513-524. Epub 2019 Feb 5.

Katharine Dormandy Haemophilia and Thrombosis Centre Royal Free Hospital London United Kingdom.

Patients with liver disease frequently develop coagulopathy, and fresh frozen plasma is traditionally used for correction of coagulopathy to manage and prevent bleeding. Prothrombin complex concentrates (PCCs) offer an attractive alternative because they are more readily available and avoid large-volume transfusion. This retrospective, single-center study reviewed clinical use of PCC in patients with acute/chronic liver disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep4.1293
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http://dx.doi.org/10.1002/hep4.1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442702PMC
April 2019
8 Reads

Aspirin for venous thromboembolism prophylaxis after hip or knee arthroplasty: An updated meta-analysis of randomized controlled trials.

J Orthop 2019 Jul-Aug;16(4):312-319. Epub 2019 Mar 26.

Hurley Medical Center, Department of Internal Medicine, Flint, MI, USA.

Background: Patients who undergo knee or hip arthroplasty are at a significant risk of venous thromboembolism (VTE) development (pulmonary embolism and/or deep-vein thrombosis). Many different thromboprophylactic strategies have been used for the prevention of VTE in these patients with different outcomes. Therefore, our aim was to evaluate the efficacy and safety of aspirin prophylaxis when compared with placebo or anticoagulants in this population of patients. Read More

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http://dx.doi.org/10.1016/j.jor.2019.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441713PMC
March 2019
1 Read

Aspirin for venous thromboembolism prophylaxis after hip or knee arthroplasty: An updated meta-analysis of randomized controlled trials.

J Orthop 2019 Jul-Aug;16(4):294-302. Epub 2019 Mar 21.

Hurley Medical Center, Department of Internal Medicine, Flint, MI, USA.

Background: Patients who undergo knee or hip arthroplasty are at a significant risk of venous thromboembolism (VTE) development (pulmonary embolism and/or deep-vein thrombosis). Many different thromboprophylactic strategies have been used for the prevention of VTE in these patients with different outcomes. Therefore, our aim was to evaluate the efficacy and safety of aspirin prophylaxis when compared with placebo or anticoagulants in this population of patients. Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441678PMC
March 2019
1 Read

Incidence and features of thrombosis in children with inherited antithrombin deficiency.

Haematologica 2019 Apr 11. Epub 2019 Apr 11.

Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain;

Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). Read More

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http://dx.doi.org/10.3324/haematol.2018.210666DOI Listing
April 2019
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Incidence and Impact of Hypoalbuminaemia on Outcomes Following Acute Pulmonary Embolism.

Heart Lung Circ 2019 Jan 30. Epub 2019 Jan 30.

Department of Cardiology, Concord Hospital, The University of Sydney, Sydney, NSW, Australia. Electronic address:

Background: Clinical features and outcomes of patients with hypoalbuminaemia in acute pulmonary embolism (PE) have never been studied. The present study investigated the incidence and determined the prognostic significance of hypoalbuminaemia in patients with confirmed acute PE.

Methods: From a dedicated tertiary-referral centre database involving 1,426 consecutive patients admitted with confirmed PE (2000-2012), 1,032 patients had serum albumin assessed on admission (day-1). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14439506193004
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http://dx.doi.org/10.1016/j.hlc.2019.01.007DOI Listing
January 2019
3 Reads

The Post Pulmonary Embolism Syndrome: Real or Ruse?

Ann Am Thorac Soc 2019 Apr 11. Epub 2019 Apr 11.

University of Pennsylvania Perelman School of Medicine, 14640, Medicine , Philadelphia, Pennsylvania, United States.

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https://www.atsjournals.org/doi/10.1513/AnnalsATS.201901-061
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http://dx.doi.org/10.1513/AnnalsATS.201901-061PSDOI Listing
April 2019
5 Reads

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.

J Clin Oncol 2019 Apr 11:JCO1801779. Epub 2019 Apr 11.

3 European Institute of Oncology IRCCS, Milan, Italy.

Purpose: Tamoxifen administered for 5 years at 20 mg/d is effective in breast cancer treatment and prevention, but toxicity has limited its broad use. Biomarker trials showed that 5 mg/d is not inferior to 20 mg/d in decreasing breast cancer proliferation. We hypothesized that a lower dose given for a shorter period could be as effective in preventing recurrence from breast intraepithelial neoplasia but have a lower toxicity than the standard dose. Read More

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http://dx.doi.org/10.1200/JCO.18.01779DOI Listing
April 2019
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Cavo-atrial thrombectomy prior to hepatectomy for hepatocellular carcinoma with tumor thrombus in the right atrium: a case report.

Surg Case Rep 2019 Apr 11;5(1):57. Epub 2019 Apr 11.

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Kawada 8-1, Shinjuku-ku, Tokyo, 162-0054, Japan.

Background: Hepatocellular carcinoma (HCC) with tumor thrombus (TT) in the right atrium is a critical condition. The general consensus is to perform hepatectomy prior to cavo-atrial thrombectomy because of the risk of uncontrollable bleeding during the liver transection after heparinization. However, sudden cardiac arrest due to the ball-valve effect and pulmonary embolism have been reported in cases of TT. Read More

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http://dx.doi.org/10.1186/s40792-019-0620-yDOI Listing
April 2019
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Approaching pulmonary fat embolism on postmortem computed tomography.

Int J Legal Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, CH-8057, Zurich, Switzerland.

Purpose: Pulmonary fat embolism (PFE) is a relevant diagnosis playing a role as a sign of vitality or a cause of death. Its severity is assessed according to histological grading systems like that of Falzi. The aim of this study was to determine the utility of unenhanced postmortem computed tomography (PMCT) for PFE diagnosis based on the detection of fat layers. Read More

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http://link.springer.com/10.1007/s00414-019-02055-8
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http://dx.doi.org/10.1007/s00414-019-02055-8DOI Listing
April 2019
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A retrospective analysis of outcomes in low- and intermediate-high-risk pulmonary embolism patients managed on an ambulatory medical unit in the UK.

ERJ Open Res 2019 Apr 8;5(2). Epub 2019 Apr 8.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Pulmonary embolism (PE) is common and guidelines recommend outpatient care only for PE patients with low predicted mortality. Outcomes for patients with intermediate-to-high predicted mortality managed as outpatients are unknown. Electronic records were analysed for adults with PE managed on our ambulatory care unit over 2 years. Read More

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http://openres.ersjournals.com/lookup/doi/10.1183/23120541.0
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http://dx.doi.org/10.1183/23120541.00184-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452043PMC
April 2019
4 Reads

Left pulmonary artery bullet embolism following a penetrating cardiac gunshot injury.

Afr J Emerg Med 2019 26;9(Suppl):S61-S63. Epub 2018 Jul 26.

Trauma and Trauma Intensive Care Unit, Inkosi Albert Luthuli Central Hospital, 800 Vusi Mzimela Road, Cato Manor, Durban 4091, South Africa.

Introduction: Bullet emboli occur when bullets migrate from an entry point to an abnormal endpoint via blood vessels or bowel. Most result from low-velocity, small calibre civilian gunshots. Although rare, when it does occur, it commonly embolises to the arterial system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2211419X183003
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http://dx.doi.org/10.1016/j.afjem.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437298PMC
July 2018
2 Reads

Catheter-Directed Thrombolysis in Acute Iliofemoral Deep Vein Thrombosis with or without Stenting: A Case Series.

J Tehran Heart Cent 2018 Oct;13(4):186-190

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Iliofemoral deep vein thrombosis (IFDVT) is a potentially devastating condition comprising a quarter of all cases of lower extremity DVT. It can lead to serious consequences such as pulmonary embolism, limb malperfusion, and post-thrombotic syndrome (PTS), which is a chronic sequela of IFDVT. We herewith present 18 IFDVT cases managed with catheter-directed thrombolysis at our hospital. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450815PMC
October 2018
2 Reads

Unusual case of intraoperative acute cor pulmonale during spine surgery.

Ann Card Anaesth 2019 Apr-Jun;22(2):229-232

Department of Cardiology, DMCH, Ludhiana, Punjab, India.

Perioperative complications of prolonged surgery and prone positioning are well known. Changing the position from prone to supine in an anesthetized patient can result in aspiration and airway obstruction. The drop-in oxygen saturation and hemodynamic changes are warning signs and can cause acute cardiac decompensation leading to diagnostic dilemma. Read More

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http://www.annals.in/text.asp?2019/22/2/229/255642
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http://dx.doi.org/10.4103/aca.ACA_128_18DOI Listing
April 2019
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SAFETY AND EFFICACY OF EUS-GUIDED COIL PLUS CYANOACRYLATE VERSUS CONVENTIONAL CYANOACRYLATE TECHNIQUE IN THE TREATMENT OF GASTRIC VARICES: A RANDOMIZED CONTROLLED TRIAL.

Arq Gastroenterol 2019 Apr 4. Epub 2019 Apr 4.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Gastroenterologia, Hospital das Clínicas, Serviço de Endoscopia Gastrointestinal, São Paulo, SP, Brasil.

Background: One of the most feared complications with the use of cyanoacrylate for treatment of gastric varices is the occurrence of potentially life-threatening systemic embolism. Thus, endoscopists are turning towards new techniques, including endoscopic coiling, as a potentially safer and more effective treatment option. However, no studies have been performed comparing the two techniques. Read More

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http://dx.doi.org/10.1590/S0004-2803.201900000-08DOI Listing
April 2019
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Primary Thrombophilia in Mexico XIII: Localization of the Thrombotic Events in Mexican Mestizos With the Sticky Platelet Syndrome.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619841700

1 Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico.

The sticky platelet syndrome (SPS) is a common cause of both arterial and venous thrombosis, being a dominant autosomal disease with qualitative platelet alterations and familial occurrence. It is characterized by platelet hyperreactivity with increased platelet aggregability in response to low concentrations of platelet agonists: epinephrine, adenosine diphosphate, or both. The clinical manifestations involve venous or arterial thrombosis, recurrent pregnancy loss, and fetal growth retardation. Read More

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http://dx.doi.org/10.1177/1076029619841700DOI Listing
April 2019
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Review of the association between periodontitis and chronic obstructive pulmonary disease in smokers.

Monaldi Arch Chest Dis 2019 Mar 20;89(1). Epub 2019 Mar 20.

Aristotle University of Thessaloniki, School of Dentistry.

Both periodontitis and chronic obstructive pulmonary disease (COPD) are among the most common diseases associated with smoking. These conditions frequently present alongside comorbidities including diabetes, coronary heart disease, duodenal ulcer, deep vein thrombosis, pulmonary embolism, osteoporosis and muscle atrophy. Chronic inflammation contributes to the pathology of both periodontitis and COPD, and in patients suffering from both conditions treatment of periodontitis may lead to relief from COPD symptoms as well. Read More

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http://dx.doi.org/10.4081/monaldi.2019.1018DOI Listing
March 2019
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