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    The effect of Angiojet rheolytic thrombectomy in the endovascular treatment of lower extremity deep venous thrombosis.
    Phlebology 2017 Jan 1:268355517711792. Epub 2017 Jan 1.
    2 Department of Cardiovascular Surgery, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
    Objective To evaluate the clinical safety and effectiveness of percutaneous rheolytic thrombectomy in patients with acute lower extremity deep venous thrombosis. Method Sixty-eight consecutive patients with acute massive lower extremity deep venous thrombosis were included in this retrospective study. A percutaneous rheolytic thrombectomy device (Angiojet ® Rheolytic thrombectomy catheter, Boston Scientific, Marlborough, MA, USA) was used in all patients in an angiography suite through ipsilateral popliteal vein access. Read More

    Platelet hyperactivation, apoptosis and hypercoagulability in patients with acute pulmonary embolism.
    Thromb Res 2017 May 13;155:106-115. Epub 2017 May 13.
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address:
    Changes in systemic redox balance can alter platelet activation and aggregation. Acute pulmonary embolism (PE) is a systematic inflammatory disease associated with mechanical shear stress, increased thrombin, catecholamines, serotonin and hemolysis, which cumulatively can hyperactivate platelets and accelerate their turnover. We tested the hypothesis that platelets from patients with moderately severe PE will show hyperstimulation and a pre-apoptotic phenotype associated with microparticles (MPs) in plasma. Read More

    Epidemiology and management of chronic thromboembolic pulmonary hypertension: Experience from two expert centers.
    Hellenic J Cardiol 2017 May 17. Epub 2017 May 17.
    First Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece. Electronic address:
    Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, distinct pulmonary vascular disease, and, therefore, there is lack of data regarding its clinical presentation, diagnosis and management at a national basis. Our objective was to describe the demographics and management of CTEPH patients in Northern Greece.

    Methods: We conducted a retrospective, observational study with a joint collaboration from two pulmonary hypertension expert centers in Greece and included patients diagnosed with CTEPH. Read More

    Recurrent Deep Vein Thrombosis After the First Venous Thromboembolism Event: A Single-Institution Experience.
    Med Sci Monit 2017 May 20;23:2391-2399. Epub 2017 May 20.
    Department of Surgery, Clinical Research, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
    BACKGROUND We investigated the frequency, clinical presentation, risk factors, and outcome after the first deep vein thrombosis (DVT) event. MATERIAL AND METHODS A retrospective study was conducted for patients with DVT between 2008 and 2012 with a 1-year follow-up. Patients were divided into 2 groups: single vs. Read More

    Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: Correlation with perfusion SPECT/CT.
    Int J Cardiol 2017 May 4. Epub 2017 May 4.
    Department of Radiology, Keio University School of Medicine, Tokyo, Japan. Electronic address:
    Background: For treatment of chronic thromboembolic pulmonary hypertension (CTEPH), the evaluation of segmental pulmonary perfusion is important. There are no previous reports about lung subtraction iodine mapping (LSIM) computed tomography (CT) for evaluation of segmental pulmonary perfusion in patients with CTEPH, using lung perfusion SPECT/CT (LPS) as the reference.

    Methods: 50 patients (age, 60. Read More

    Outpatient management of pulmonary embolism.
    Thromb Res 2017 May 4;155:92-100. Epub 2017 May 4.
    Department of Pneumology, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
    Despite clear potential benefits of outpatient care, most patients suffering from pulmonary embolism (PE) are currently hospitalized due to the fear of possible adverse events. Nevertheless, some teams have increased or envisage to increase outpatient treatment or early discharge. We performed a narrative systematic review of studies published on this topic. Read More

    An Unusual Case of Sudden Death: Is There a Relationship Between Thyroid Disorders and Fatal Pulmonary Thromboembolism? A Case Report and Review of Literature.
    Am J Forensic Med Pathol 2017 May 19. Epub 2017 May 19.
    From the *Institute of Legal Medicine, University "La Sapienza," Rome; and †Institute of Legal Medicine, University "Magna Graecia," Catanzaro, Italy.
    In adults, the most common cause of sudden death is coronary heart disease or defects in the cardiac conduction system; however, there are many cases of sudden death occurring from other causes such as fatal pulmonary thromboembolism. Several risk factors are recognized, including hospitalization, surgery, obesity, pregnancy, the use of oral contraceptives, traumatic fractures, and genetic conditions, which cause hypercoagulable states such as factor V Leiden mutations. Although many risk factors have been identified, the mortality rate is still high. Read More

    A chronic thromboembolic pulmonary hypertension catch-22 situation: inferior vena caval filter plays a pivotal role in an unlikely situation.
    J Thorac Dis 2017 Apr;9(4):E346-E348
    Department of Cardiovascular Surgery, Mount Sinai Medical Center, New York, NY, USA.
    Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare clinical entity that occurs in a small subset of acute pulmonary embolism (PE) cases and is surgically cured by pulmonary endarterectomy. We report a case of a 44-year-old female with a complex history of CTEPH treated by thromboendarterectomy who presented with a subdural hematoma while on warfarin. The patient eventually recovered by a multidisciplinary approach, use of inferior vena caval filter, and effective anticoagulation management. Read More

    Trends in socioeconomic costs of morbid obesity among Korean adults, 2009-2013: Data from National Health Insurance Service.
    Obes Res Clin Pract 2017 May 15. Epub 2017 May 15.
    Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang-si, Republic of Korea. Electronic address:
    As the prevalence of morbid obesity increased in Korea, the estimation of the accurate socioeconomic costs by morbid obesity was required; we analysed national medical costs through the big data. From 2009 year to 2013 year, Direct Costs (DC) for medical costs, transit costs and nursing costs and Indirect Costs (IC) for Future Income Loss (FIL) and Productivity Loss (PL) of morbid obesity (BMI≥30) were calculated, and socioeconomic costs were estimated by applying Population Attributable Risk (PAR) proportion according to obesity related diseases. From 10 year follow up research, Relative risk (RR) for morbid obesity related disease was analysed in comparison with control group. Read More

    Usefulness of D-dimer testing in predicting recurrence in elderly patients with unprovoked venous thromboembolism.
    Am J Med 2017 May 15. Epub 2017 May 15.
    Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Background: Whether post-anticoagulation D-dimer levels are useful in predicting recurrence in elderly patients with unprovoked venous thromboembolism is unknown.

    Methods: We followed-up 157 patients aged ≥65 years with acute symptomatic unprovoked venous thromboembolism in a prospective multicenter cohort study. All patients completed 3-12 months of anticoagulation and then underwent quantitative D-dimer testing (ELISA, VIDAS DD) 12 months after the index venous thromboembolism. Read More

    Cost-effectiveness analysis of rivaroxaban for treatment and secondary prevention of venous thromboembolism in the Netherlands.
    J Med Econ 2017 May 18:1-27. Epub 2017 May 18.
    d Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy , University of Groningen , Groningen , NL ; Department of Epidemiology , University Medical Center Groningen (UMCG), University of Groningen , Groningen , NL ; Institute of Science in Healthy Aging & healthcaRE (SHARE), UMCG, University of Groningen , Groningen , NL.
    Background: Until recently, standard treatment of venous thromboembolism (VTE) concerned a combination of short-term low-molecular-weight heparin (LMWH) and long-term vitamin-K antagonist (VKA). Risk of bleeding and the requirement for regular anticoagulation monitoring are, however, limiting their use. Rivaroxaban is a novel oral anticoagulant associated with a significantly lower risk of major bleeds (hazard ratio 0. Read More

    Economic evaluation of strategies for restarting anticoagulation therapy after a first event of unprovoked venous thromboembolism.
    J Thromb Haemost 2017 May 18. Epub 2017 May 18.
    University of Birmingham, Birmingham, UK.
    Background: Following at least three months of anticoagulation therapy after a first unprovoked Venous Thromboembolism (VTE), there is uncertainty about the duration of therapy. Further anticoagulation therapy reduces the risk of having a potentially fatal recurrent VTE but at the expense of a higher risk of bleeding which can also be fatal.

    Objective: An economic evaluation sought to estimate the long-term cost-effectiveness of using a decision rule for restarting anticoagulation therapy versus no extension of therapy in patients based on their risk of a further unprovoked VTE. Read More

    Single-incision totally extraperitoneal inguinal hernia repair is feasible and safe in patients on antithrombotic therapy: A single-center experience of 92 procedures.
    Asian J Endosc Surg 2017 May 17. Epub 2017 May 17.
    Department of Surgery, Osaka Police Hospital, Osaka, Japan.
    Introduction: The aim of this study was to evaluate the feasibility and safety of SILS for totally extraperitoneal inguinal hernia repair for patients on antithrombotic therapy.

    Methods: A total of 365 patients who underwent SILS for totally extraperitoneal inguinal hernia repair between January 2011 and November 2015 were analyzed retrospectively. Antithrombotic drugs were stopped preoperatively, and bridging intravenous heparin therapy was given according to the operative risk of each patient. Read More

    Cerebral air embolism associated with penetrating lung injury: a case report and review of the literature.
    Acute Med Surg 2017 Apr 10;4(2):213-216. Epub 2016 Nov 10.
    Department of Diagnostic RadiologySapporo Medical UniversitySapporoHokkaidoJapan.
    Case: A 44-year-old man intentionally stabbed himself in the anterior neck and left thorax with a fruit knife. Physical examination revealed two open wounds entering the thoracic cavity in the front chest, and a stab wound entering the trachea at the neck. Two chest tubes were initially inserted for the left lung injury with open hemopneumothorax. Read More

    Thromboembolic complications after an ankle joint open fracture in a patient with a history of deep vein thrombosis in the lower limbs.
    Kardiochir Torakochirurgia Pol 2017 Mar 31;14(1):47-49. Epub 2017 Mar 31.
    Department of Cardiac Surgery, Medinet Heart Center Ltd, Wrocław, Poland.
    A 55-year-old patient was admitted to the Department of Orthopedics due to an open fracture in the right ankle joint. On the seventh day of hospitalization the patient experienced a transient ischemic attack. During the next day, dyspnea, chest pain and a 'rider' type pulmonary embolism in the pulmonary trunk occluding both pulmonary arteries and its branches were diagnosed. Read More

    Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women.
    J Am Heart Assoc 2017 May 17;6(5). Epub 2017 May 17.
    Cancer Epidemiology Unit, University of Oxford, United Kingdom.
    Background: Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and with use of antidepressant drugs. We explored these associations in a large prospective study of UK women.

    Methods And Results: The Million Women Study recruited 1. Read More

    Predictive Factors for Developing Venous Thrombosis during Cisplatin-Based Chemotherapy in Testicular Cancer.
    Urol Int 2017 May 18. Epub 2017 May 18.
    Department of Urology, University Hospital Cologne, Cologne, Germany.
    Background: Malignancies and cisplatin-based chemotherapy are both known to correlate with a high risk of venous thrombotic events (VTT). In testicular cancer, the information regarding the incidence and reason of VTT in patients undergoing cisplatin-based chemotherapy is still discussed controversially. Moreover, no risk factors for developing a VTT during cisplatin-based chemotherapy have been elucidated so far. Read More

    Subacute pulmonary embolism in a hemodialysis patient, successfully treated with surgical thrombectomy.
    CEN Case Rep 2016 May 11;5(1):74-77. Epub 2016 Feb 11.
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    A 53-year-old woman was admitted to our hospital with a 1-month history of gradually progressive resting dyspnea and lumbar backache. For the preceding 6 years, she had received regular hemodialysis for end-stage renal disease caused by autosomal dominant polycystic kidney disease and had taken tamoxifen for 3 years as post-operative chemotherapy for breast cancer. Before admission, the patient's symptoms had been attributed to volume overload, based on right thoracic fluid and leg edema. Read More

    Direct oral anticoagulants for the treatment of cancer-associated venous thromboembolism. What do we know so far?
    Hamostaseologie 2017 May 16. Epub 2017 May 16.
    Priv.-Doz. Dr. med. Florian Langer, II. Medizinische Klinik und Poliklinik, Hubertus Wald Tumorzentrum - Universitäres Cancer Center Hamburg (UCCH), Universitätsklinikum Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany, Phone: +49-40-7410-52453/-50664, Fax: +49-40-7410-55193, E-Mail:
    Cancer patients with venous thromboembolism (VTE) are at increased risk for both bleeding and VTE recurrence. Anticoagulation with low-molecular-weight heparin (LMWH) is the standard of care during the initial and long-term treatment phase (i.e. Read More

    Admission D-dimer testing for differentiating acute aortic dissection from other causes of acute chest pain.
    Arch Med Sci 2017 Apr 20;13(3):591-596. Epub 2017 Apr 20.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Introduction: The present study aims to evaluate the utility of D-dimer testing for differentiating the causes of acute chest pain, including acute aortic dissection (AAD), pulmonary embolism (PE), acute myocardial infarction (AMI), unstable angina (UA), and other uncertain diagnoses of chest pain.

    Material And Methods: Consecutive patients admitted for acute chest pain within 24 h from symptom onset were enrolled prospectively, and plasma D-dimer levels were measured on admission. Diagnoses of AAD, PE, AMI, and UA were confirmed by standard methods. Read More

    [Sudden death in Versailles: A review of a cardiovascular treatrise by Dionis (1710)].
    Ann Cardiol Angeiol (Paris) 2017 May 12. Epub 2017 May 12.
    Équipe d'anthropologie médicale et médicolégale, UFR des sciences de la santé, UVSQ, EA 4569 Paris-Descartes, 78180 Montigny-Le-Bretonneux, France; CASH/IPES, 403, boulevard de la République, 92000 Nanterre, France. Electronic address:
    In 1710, the surgeon Pierre Dionis publishes a Dissertation on sudden death. Echoing and expanding the work of his Roman colleague Jean Marie Lancisi, he describes and analyzes dozens of cases of sudden death observed by him. A large number of cases was followed by autopsies allowing clinicopathological confrontation. Read More

    Successful Team-Based Management of Renal Cell Carcinoma With Caval Extension of Tumor Thrombus Above the Diaphragm.
    J Cardiothorac Vasc Anesth 2017 Feb 9. Epub 2017 Feb 9.
    Cardiovascular and Thoracic Section, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

    Is there a "July effect" in pediatric neurosurgery?
    Childs Nerv Syst 2017 May 13. Epub 2017 May 13.
    Division of Pediatric Neurosurgery, Texas Children's Hospital, 6701 Fannin St., Ste. 1230, Houston, TX, 77030, USA.
    Purpose: The belief that July, when resident physicians' training year begins, may be associated with increased risk of patient morbidity and mortality is known as the "July effect." This study aimed to compare complication rates after pediatric neurosurgical procedures in the first versus last academic quarters in two national datasets.

    Methods: Data were extracted from the National Surgical Quality Improvement Program-Pediatrics (NSQIP-P) database for year 2012 for 30-day complication events and the Kids' Inpatient Database (KID) for year 2012 for in-hospital complication events after pediatric neurosurgical procedures. Read More

    Different manifestations of pulmonary embolism in younger compared to older patients: Clinical presentation, prediction rules and long-term outcomes.
    Adv Med Sci 2017 May 11;62(2):254-258. Epub 2017 May 11.
    Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
    Purpose: Data concerning specific manifestations of pulmonary embolism (PE) among younger patients are scarce. We aimed to evaluate differences in clinical presentation, PE prediction rules, thrombolytic treatment use and PE outcomes in younger (<50 years of age) compared to older patients.

    Material/methods: We studied 238 consecutive patients with proven PE who were retrospectively categorized into three PE probability subgroups according to the revised Geneva score (RGS) and Wells score (WS). Read More

    An Unexpectedly High rate of Thrombophilia Disorders in Patients with Superficial Vein Thrombosis of the Lower Extremities.
    Ann Vasc Surg 2017 May 10. Epub 2017 May 10.
    Division of Vascular and Endovascular Surgery, Department of Surgery and Orthpedics - Botucatu Medical School -UNESP.
    Background: Superficial vein thrombosis is a common venous condition. Recent studies have shown that SVT is associated with high frequency of thromboembolic complications: from 22 to 37 % for deep venous thrombosis and up to 33% for pulmonary embolism.

    Objectives: To assess the prevalence of major hereditary and acquired thrombophilic factors in patients with SVT. Read More

    Systemic Thrombolytic Therapy and Catheter-directed Fragmentation with Local Thrombolytic Therapy in Patients with Pulmonary Embolism.
    Ann Vasc Surg 2017 May 10. Epub 2017 May 10.
    Academician E.N. Meshalkin Novosibirsk State Budget Research Institute of Circulation Pathology", Ministry for Public Health Care Russian Federation Novosibirsk, Russian Federation.
    The objective was to compare immediate and long-term results of systemic thrombolytic therapy (STT) and catheter-directed fragmentation (CDF) with local thrombolytic therapy (LTT) in patients with massive pulmonary embolism (PE).

    Methods: 209 patients with massive PE (the high risk of early death) were included in our study. From 2008 till 2010 in the first group (n=102) STT was performed. Read More

    Endovascular stenting for end-stage lung cancer patients with superior vena cava syndrome post first-line treatments - A single-center experience and literature review.
    J Chin Med Assoc 2017 May 10. Epub 2017 May 10.
    Division of Cardiovascular Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address:
    Background: Superior vena cava (SVC) syndrome is a major complication that occurs when a growing lung malignancy compresses the SVC extrinsically. Current treatment options include radiotherapy or chemotherapy to shrink the tumor or endovascular stenting of the SVC to restore flow. Herein, we report a case series treated in a single institution to demonstrate the safety, effectiveness, and outcomes of salvage and primary stenting for malignant SVC obstruction. Read More

    Association of folate metabolism gene polymorphisms and haplotype combination with pulmonary embolism risk in Chinese Han population.
    Mamm Genome 2017 May 12. Epub 2017 May 12.
    Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Yiyuan Street No. 37 of Nangang District, Harbin City, 150001, Heilongjiang Province, China.
    In this study, we aimed to investigate the association of four single nucleotide polymorphisms (SNPs) (MTHFR 677 C > T, MTHFR 1298 A > C, MTR 2756 A > G and MTRR 66 A > G), gene-gene interaction and haplotype combination with pulmonary embolism (PE) risk based on Chinese Han population. Logistic regression was performed to investigate association between four SNPs within folate metabolism gene and PE risk, and GMDR model was used to investigate the additional gene-gene interactions among the four SNPs. Logistic analysis showed that rs1801133 and rs1801131 in MTHFR gene were associated with increased PE risk in both additive and dominant models. Read More

    Association of elevated pulmonary artery systolic pressure with stroke and systemic embolic events in patients with hypertrophic cardiomyopathy.
    Int J Cardiol 2017 May 5. Epub 2017 May 5.
    Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
    Background: Echocardiographically estimated pulmonary artery systolic pressure (PASP) is a non-invasive widely available method that is used to estimate pulmonary arterial pressure. Although elevated PASP predicts mortality in patients with hypertrophic cardiomyopathy (HCM), the relationship between PASP and embolic events is unclear. This study aimed to determine whether elevated PASP is associated with stroke and systemic embolic events in a tertiary referral HCM cohort. Read More

    Ultrasound-assisted thrombolysis of an occluded transjugular portosystemic shunt.
    Diagn Interv Radiol 2017 May 12. Epub 2017 May 12.
    Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    Transjugular intrahepatic portosystemic shunt (TIPS) insertion is commonly performed for refractory ascites or variceal bleeding. However, TIPS dysfunction can be seen in both early and late settings, with shunt thrombosis a particular problem. Treatment of shunt dysfunction commonly involves angioplasty and re-lining, with or without embolectomy, mechanical thrombectomy, or thrombolysis. Read More

    Does Syncope Predict Mortality in Patients With Acute Pulmonary Embolism? A Retrospective Review.
    J Clin Med Res 2017 Jun 26;9(6):516-519. Epub 2017 Apr 26.
    Bassett Medical Center, One Atwell Road, Cooperstown, NY 13326, USA.
    Background: Acute pulmonary embolism (APE) is a potentially fatal disease with high mortality. Prior studies have shown an increased frequency of central localization of the clot, right ventricular dysfunction and elevated troponin in patients who present with syncope and APE. Existing evidence regarding mortality and length of hospital stay in these patients is unclear. Read More

    Venous thromboembolism in patients with pemphigus: A cohort study.
    J Am Acad Dermatol 2017 May 8. Epub 2017 May 8.
    Department of Dermatology, Beilinson Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Venous thromboembolism (VTE) has been reported to be a significant cause of death in patients with pemphigus.

    Objective: We sought to assess the incidence and characteristics of VTE in patients with pemphigus.

    Methods: A retrospective study following a cohort of 172 patients with newly diagnosed pemphigus for the development of VTE was conducted. Read More

    Transthoracic Echocardiography for Diagnosing Pulmonary Embolism: A Systematic Review and Meta-Analysis.
    J Am Soc Echocardiogr 2017 May 9. Epub 2017 May 9.
    Lister Hill Library, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
    Objective: Pulmonary embolism (PE) is a common diagnosis with significant mortality if not appropriately treated. The use of transthoracic echocardiography in patients with PE is common; however, its diagnostic capabilities in this use are unclear. With the increased use of ultrasonography in medical settings, it is important to understand the strengths and limitations of echocardiography for the diagnosis of PE. Read More

    Risk factors for pulmonary complication following operative fixation of spine fractures.
    Spine J 2017 May 8. Epub 2017 May 8.
    Department of Orthopaedic Surgery, MetroHealth Medical Center, 2500 MetroHealth Dr., Cleveland, Ohio, 44109. Electronic address:
    Background Context: Previous studies have suggested pulmonary complications are common among patients undergoing fixation for traumatic spine fractures. This leads to prolonged hospital stay, worse functional outcomes, and increased economic burden. However, only limited prognostic information exists regarding which patients are at greatest risk for pulmonary complications. Read More

    Idiopathic inflammatory myopathy and the risk of venous thromboembolism: a meta-analysis.
    Rheumatol Int 2017 May 10. Epub 2017 May 10.
    Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Korea.
    This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Read More

    Corrective osteotomies of the lower limb show a low intra- and perioperative complication rate-an analysis of 1003 patients.
    Knee Surg Sports Traumatol Arthrosc 2017 May 10. Epub 2017 May 10.
    , Buger Str. 80, 96049, Bamberg, Germany.
    Purpose: The purpose of corrective osteotomies in posttraumatic and congenital deformities is anatomic limb reconstruction and joint preservation. The aim of the present study was to analyse intra- and perioperative complications of osteotomies in the lower limb.

    Methods: One thousand and three unselected and prospectively registered osteotomies of the long bones of the lower limb, performed between 1995 and 2013, were analysed. Read More

    Pulmonary Embolism and Deep Venous Thrombosis in Patients Hospitalized With Syncope: A Multicenter Cross-sectional Study in Toronto, Ontario, Canada.
    JAMA Intern Med 2017 May 8. Epub 2017 May 8.
    Division of General Internal Medicine, Department of Medicine, University of Toronto, Toronto, Ontario Canada.5Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.6Division of General Internal Medicine, St. Michael's Hospital, Toronto, Ontario, Canada. 7Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.

    Vena Cava Filter Use in Trauma and Rates of Pulmonary Embolism, 2003-2015.
    JAMA Surg 2017 May 10. Epub 2017 May 10.
    Trauma and Acute Care Surgery, Penn Medicine Lancaster General Health, Lancaster, Pennsylvania.
    Importance: Vena cava filter (VCF) placement for pulmonary embolism (PE) prophylaxis in trauma is controversial. Limited research exists detailing trends in VCF use and occurrence of PE over time.

    Objective: To analyze state and nationwide temporal trends in VCF placement and PE occurrence from 2003 to 2015 using available data sets. Read More

    Accidental intravenous administration of paracetamol syrup in a child.
    Arch Pediatr 2016 Dec 27;23(12):1251-1253. Epub 2016 Oct 27.
    Department of life and reproduction sciences, pediatrics, university of Verona, Verona, Italy.
    Objective And Importance: Medication administration errors occur frequently in clinical practice.

    Clinical Presentation: An 18-month-old child presented with vomiting and diarrhea. Due to a rise in temperature, paracetamol syrup was prescribed, but a nurse inadvertently administered the drug IV through the peripheral venous access. Read More

    Referral Patterns and Diagnostic Yield of Lung Scintigraphy in the Diagnosis of Acute Pulmonary Embolism.
    Thrombosis 2017 11;2017:1623868. Epub 2017 Apr 11.
    Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6.
    Introduction. The purpose of this study is to assess referral patterns and the yield of ventilation-perfusion (V/Q) scintigraphy in patients referred for acute pulmonary embolism (PE). Methods. Read More

    Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription.
    SAGE Open Med Case Rep 2017 31;5:2050313X17695999. Epub 2017 Mar 31.
    Department of Psychological Medicine, King's College Hospital, South London and Maudsley NHS Foundation Trust, London, UK.
    Objectives: To describe a case of neuroleptic malignant syndrome following antipsychotic treatment of catatonia, highlighting the potentially serious complications of this rare adverse drug reaction.

    Methods: We present a case report of a patient who developed this syndrome with various sequelae.

    Results: The patient developed neuroleptic after being treated with lorazepam and olanzapine for catatonia. Read More

    [Syncope; suspect pulmonary embolism, especially in the elderly].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1365
    Nederlands Huisartsen Genootschap, afd. Richtlijnontwikkeling en Wetenschap, Utrecht.
    Syncope can be caused by a pulmonary embolism. This applies in particular to elderly patients admitted with syncope; in the general population, however, syncope is far more frequently caused by a vasovagal response or orthostatic hypotension. Syncope can be the symptom of a pulmonary embolism, even in the absence of any clinical manifestations of this diagnosis; it is, therefore, important to exclude pulmonary embolism in any syncope patient in the accident and emergency department by applying the Wells clinical decision rule. Read More

    Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism.
    Int J Mol Med 2017 Jun 26;39(6):1580-1588. Epub 2017 Apr 26.
    Department of ICU, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.
    The present study aimed to explore the influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism (APE) in rats. Our previous study found that CX3CL1/CX3CR1 was increased in APE. However, the effect of this signaling pathway on APE remains unclear. Read More

    Deriving literature-based benchmarks for surgical complications in high-income countries: a protocol for a systematic review and meta-analysis.
    BMJ Open 2017 May 9;7(5):e013780. Epub 2017 May 9.
    Ariadne Labs, Boston, Massachusetts, USA.
    Introduction: To improve surgical safety, health systems must identify preventable adverse outcomes and measure changes in these outcomes in response to quality improvement initiatives. This requires understanding of the scope and limitations of available population-level data. To derive literature-based summary estimates of benchmarks of care, we will systematically review and meta-analyse rates of postoperative complications associated with several common and/or high-risk operations performed in five high-income countries (HICs). Read More

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