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    Proximal Femoral Fractures and Anticoagulation Therapy - When Is Surgery Safe?
    Acta Chir Orthop Traumatol Cech 2017 ;84(5):323-329
    Klinik für Unfallchirurgie, Orthopädie und Handchirurgie, Klinikum Wolfsburg, Wolfsburg, Germany.
    Patients presenting with proximal femur fractures are at high risk of developing DVT and pulmonary embolism. Many of these patients suffer from additional anticoagulant treatment. Patients on anticoagulation treatment are complex to manage, especially regarding timing of surgery due to implemented quality control recommendations. Read More

    Fatal Sickling Triggered by Massive Foreign Particle Embolism: A Case Report of Unrecognized Indwelling Venous Catheter Drug Abuse in Sickle Cell Disease.
    Am J Forensic Med Pathol 2018 Jan 18. Epub 2018 Jan 18.
    From the Arkadi M. Rywlin, MD, Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL.
    Sickle cell disease (SCD) manifests itself with vaso-occlusive episodes leading to infarction. Placement of intravascular catheters provides a useful route for management of pain crises as well as other complications. However, catheter misuse is a commonly unrecognized problem, which can have lethal consequences. Read More

    Commentary to 18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots-Are We Getting There?
    Mol Imaging 2018 Jan-Dec;17:1536012117749052
    1 Piramal Imaging GmbH, Berlin, Germany.
    Thrombus formation can lead to heart attacks, stroke and pulmonary embolism, which are major causes of mortality. Current standard diagnostic imaging methods detect anatomic abnormalities such as vascular flow impairment but have limitations. By using a targeted molecular imaging approach critical components of a pathology can be selectively visualized and exploited for an improved diagnosis and patient management. Read More

    [Percutaneous vertebroplasty and open vertebroplasty for metastatic spinal tumor].
    Zhongguo Gu Shang 2017 Feb;30(2):115-120
    Department of Orthopaedics, the Affiliated Hospital of Jiangnan University, the 4th People's Hospital of Wuxi, Wuxi 214062, Jiangsu, China.
    Objective: To explore the clinical application and therapeutic effect of percutaneous vertebroplasty(PVP) and open vertebroplasty for metastatic spinal tumor.

    Methods: The clinical data of 126 patients with metastatic spinal tumor underwent surgery and obtained follow-up from January 2012 to March 2016 were retrospectively analyzed. These 126 cases were divided into two groups according to different operative methods. Read More

    [Effects of tranexamic acid combined with temporary drain clamping on postoperative blood loss in total knee arthroplasty].
    Zhongguo Gu Shang 2017 Apr;30(4):329-333
    Department of Orthopaedics, the Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang, China.
    Objective: To evaluate the efficacy and safety of one dose tranexamic acid combined with temporary drain lamping in primary unilateral total knee arthroplasty.

    Methods: Total 160 patients undergoing unilateral primary total knee arthroplasty between January 2012 and December 2013 were randomly divided into four groups(40 cases in each group):group A (the drain was clamped for 2 hours after the operation and the patients received 20 ml physiological saline), group B(the drain was clamped for 2 hours after the operation and the patients received 10 ml tranexamic acid and 10 ml physiological saline), group C (the drain was clamped for 4 hours after the operation and the patients received 20 ml physiological saline) and group D(the drain was clamped for 4 hours after the operation and the patients received 10 ml tranexamic acid and 10 ml physiological saline). The postoperative hemoglobin level, maximum hemoglobin loss, wound drainage, blood loss, the volume of blood transfusion, the number of patients inquiring blood transfusion, venous thrombo embolism rate, and ecchymosis rate were recorded and compared among the four groups. Read More

    [Capsular-enhanced repair with suture anchors in bipolar hemiarthroplasty for the treatment of femoral neck fractures in elderly patients].
    Zhongguo Gu Shang 2017 Apr;30(4):313-317
    Department of Orthopaedics, Mianyang Central Hospital, Mianyang 621000, Sichuan, China.
    Objective: To evaluate the efficacy of capsular-enhanced repair with suture anchors in bipolar hemiarthroplasty for the treatment of femoral neck fractures in elderly patients.

    Methods: A retrospective study was designed. From June 2009 to June 2016, 53 senile patients (54 hips)with femoral neck fracture were treated operatively in Mianyang central hospital (Sichuan, China). Read More

    Outcomes in syncope research: a systematic review and critical appraisal.
    Intern Emerg Med 2018 Jan 18. Epub 2018 Jan 18.
    Dipartimento di Medicina Interna, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
    Syncope is the common clinical manifestation of different diseases, and this makes it difficult to define what outcomes should be considered in prognostic studies. The aim of this study is to critically analyze the outcomes considered in syncope studies through systematic review and expert consensus. We performed a systematic review of the literature to identify prospective studies enrolling consecutive patients presenting to the Emergency Department with syncope, with data on the characteristics and incidence of short-term outcomes. Read More

    Value of CT pulmonary angiography to predict short-term outcome in patient with pulmonary embolism.
    Int J Cardiovasc Imaging 2018 Jan 18. Epub 2018 Jan 18.
    Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    To evaluate the role of CT pulmonary angiography (CTPA) in the assessment of pulmonary embolism (PE) severity and the related CT cardiac changes, reflecting the clinical status of the patients and predicting the outcome. A prospective study of 184 patients presented with suspicious acute PE. All patients underwent CTPA followed by ECHO. Read More

    Single-session total endovascular iliocaval reconstruction with stent grafting for the treatment of inferior vena cava agenesis and concurrent iliac venous aneurysm rupture.
    J Vasc Surg Cases Innov Tech 2017 Sep 18;3(3):132-135. Epub 2017 Jul 18.
    Division of Vascular and Interventional Radiology, Department of Radiology, University of Michigan Health System, Ann Arbor, Mich.
    Iliac venous aneurysms are rare vascular abnormalities that may be manifested by abdominal masses, pelvic tenderness, or hypovolemia and may lead to rupture, thrombosis, pulmonary embolism, paradoxical embolism, or death. Inferior vena cava agenesis, like venous aneurysm, is an uncommon condition that may present with deep venous thrombosis. This report describes a patient with inferior vena cava agenesis and iliac venous aneurysm rupture treated with emergent iliocaval reconstruction and endovascular stent graft placement. Read More

    Budd-Chiari syndrome: a rare and life-threatening complication of Crohn's disease.
    BMJ Case Rep 2018 Jan 17;2018. Epub 2018 Jan 17.
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
    Budd-Chiari syndrome (BCS) is characterised by obstruction of hepatic venous outflow and may be triggered by the prothrombotic state associated with inflammatory bowel disease (IBD). We reported a case of Crohn's disease (CD) that presented with anasarca, ascites, symptomatic hepatomegaly, elevated liver enzymes, increased prothrombin time and low albumin. Oesophagogastroduodenoscopy and colonoscopy confirmed active CD. Read More

    Rash associated with rivaroxaban use.
    Am J Health Syst Pharm 2018 Jan 18. Epub 2018 Jan 18.
    Departments of Hematology/Oncology and Medicine, Bassett Medical Center, Cooperstown, NY.
    Purpose: A case of a patient who developed a hypersensitivity reaction to rivaroxaban in the form of a diffuse, exanthematous rash is reported.

    Summary: After starting rivaroxaban for treatment of cancer-associated deep vein thrombosis (DVT) with pulmonary embolism (PE), a 69-year-old Caucasian woman arrived at an oncology clinic with a diffuse, exanthematous (morbilliform) rash on her neck and torso, spreading to her upper and lower extremities. She reported that the symptoms started to develop about 48 hours after transitioning from subcutaneous enoxaparin to oral rivaroxaban. Read More

    Effectiveness of a Patient Education Plan on Knowledge ofPost-Op Venous Thromboembolism Survival Skills.
    J Clin Nurs 2018 Jan 18. Epub 2018 Jan 18.
    Office of Nursing Research and Innovation, Cleveland Clinic, 9500 Euclid Avenue P33, Cleveland, OH44195.
    Aims And Objectives: To investigate the effectiveness of a multi-method venous thromboembolism prevention patient education plan on participants' knowledge retention.

    Background: A potential complication of surgery requiring general anesthesia, worldwide, is the development of life-threatening venous thromboembolism. Patients need education on preventing, recognizing, and immediately responding to a suspected thromboembolism. Read More

    Investigation of perioperative safety and clinical results of one-stage bilateral total knee arthroplasty in selected low-risk patients.
    J Orthop Surg Res 2018 Jan 17;13(1):14. Epub 2018 Jan 17.
    Department of Orthopaedic Surgery, Ichihara Hospital, 3681 Ozone, Tsukuba, Ibaraki, 300-3295, Japan.
    Background: An increased perioperative complication rate has been a concern with one-stage bilateral total knee arthroplasty (TKA). The purpose of this study was to retrospectively investigate the perioperative safety and clinical results of one-stage bilateral TKA in selected low-risk patients.

    Methods: Sixty-seven patients who received one-stage bilateral TKAs for osteoarthritis who were American Society of Anesthesiology (ASA) class 1 or 2 were included in this study. Read More

    An unusual case of symptomatic deep vein thrombosis and pulmonary embolism after arthroscopic meniscus surgery.
    BMC Musculoskelet Disord 2018 Jan 17;19(1):19. Epub 2018 Jan 17.
    Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, No.88 Jiefang Road, Hangzhou, 310009, People's Republic of China.
    Background: Although thrombosis complication is rare after arthroscopic meniscus surgery, deep vein thrombosis and pulmonary embolism can be fatal. The associated risk factors and whether anticoagulant prevention after arthroscopic knee surgery is necessary have not reach consensus. Here we present a case of deep vein thrombosis and pulmonary embolism after a common arthroscopic meniscectomy. Read More

    Age Adjusted D-Dimer for exclusion of Pulmonary Embolism: a retrospective cohort study.
    Ir Med J 2017 Aug 8;110(7):599. Epub 2017 Aug 8.
    St. Vincent's University Hospital, Elm Park, Donnybrook, D4, Ireland.
    D-Dimer (DD) will increase with age and recent studies have shown the upper limit of normal can be raised in those who are low risk and over 50. We studied age adjusted D-dimer (AADD) levels to assess whether pulmonary embolism (PE) could be safely excluded. This study analysed the Emergency Department (ED) Computed Tomographic Pulmonary Angiography (CTPA) requests. Read More

    Clinical Value of Ultrasonography in Diagnosis of Pulmonary Embolism in Critically Ill Patients.
    J Transl Int Med 2017 Dec 29;5(4):200-204. Epub 2017 Dec 29.
    Department of Critical Care Medicine, the First Affiliated Hospital of China Medical University, Shenyang110001, Liaoning Province, China.
    Pulmonary embolism (PE) is a clinical emergency that will increase the mortality if complicated with unstable hemodynamics. Because of its nonspecific clinical symptoms, it's a great challenge to make a PE diagnosis. The golden standard to diagnose PE is computed tomography of pulmonary artery (CTPA), but a diagnosis of PE also composed of evaluation of PE risk factors, possibilities, and risk stratification. Read More

    Family history of venous thromboembolism predicts the diagnosis of acute pulmonary embolism in the emergency department.
    Am J Emerg Med 2018 Jan 6. Epub 2018 Jan 6.
    Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States. Electronic address:
    Background: Pulmonary embolism (PE) clinical decision rules do not consider a patient's family history of venous thromboembolism (VTE). We evaluated whether a family history of VTE predicts acute PE in the emergency department (ED).

    Methods: Over a 5. Read More

    Accidental Rivaroxaban Intoxication in a Boy: Some Lessons in Managing New Oral Anticoagulants in Children.
    Pediatr Emerg Care 2018 Jan 15. Epub 2018 Jan 15.
    Novel oral anticoagulants offer equivalent or improved therapeutic profiles compared with warfarin, with less risk of bleeding, no interactions with food, and no need for routine laboratory monitoring. Caution must be exercised in using these drugs in certain patient populations, for example, renal insufficiency, those receiving additional antithrombotic therapy, those with questionable compliance, children, and those with a high risk of gastrointestinal bleeding. One of the novel oral anticoagulants, rivaroxaban, is a direct Factor Xa inhibitor, used to reduce risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Read More

    A Clinically Meaningful Interpretation of the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) II and III Data.
    Acad Radiol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Radiology, University of Michigan Health System, B1 132G Taubman Center/5302, 1500 East Medical Center, Ann Arbor, MI 48109; Nuclear Medicine Service, VA Ann Arbor Health Care System, Ann Arbor, Michigan.
    Rationale And Objectives: This study aimed to calculate the multiple-level likelihood ratios (LRs) and posttest probabilities for a positive, indeterminate, or negative test result for multidetector computed tomography pulmonary angiography (MDCTPA) ± computed tomography venography (CTV) and magnetic resonance pulmonary angiography (MRPA) ± magnetic resonance venography (MRV) for each clinical probability level (two-, three-, and four-level) for the nine most commonly used clinical prediction rules (CPRs) (Wells, Geneva, Miniati, and Charlotte). The study design is a review of observational studies with critical review of multiple cohort studies. The settings are acute care, emergency room care, and ambulatory care (inpatients and outpatients). Read More

    Endovascular recanalization for nonmalignant obstruction of the inferior vena cava.
    J Vasc Surg Venous Lymphat Disord 2018 Jan 11. Epub 2018 Jan 11.
    Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minn.
    Objective: The aim of this study was to evaluate outcomes of endovascular recanalization of the inferior vena cava (IVC) and iliac veins with long-standing chronic venous obstruction caused by nonmalignant disease.

    Methods: Medical records for 66 patients who underwent endovascular recanalization of the IVC with or without iliac veins from January 2001 to December 2014 at our medical center were retrospectively reviewed. Primary outcomes included morbidity and mortality; secondary outcomes included primary, primary assisted, and secondary patency and resolution of symptoms. Read More

    The role of extended venous thromboembolism prophylaxis following urologic pelvic surgery.
    Urol Oncol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY.
    With the emergence of evidence that venous thromboembolisms (VTE) typically occurs following discharge after urologic pelvic surgery, the focus on extended VTE prophylaxis has intensified. Urologists should have a comprehensive understanding of various VTE risk factors in order to weigh the risk of postoperative hemorrhage with the possibility of fatal pulmonary embolus. Risk factors such as advanced age, obesity, and active malignancy are especially common in patient's undergoing urologic pelvic surgery, and thus this issue becomes particularly relevant to the practicing urologist. Read More

    Impact of medication adherence on risk of ischemic stroke, major bleeding, and deep vein thrombosis in atrial fibrillation patients using novel oral anticoagulants.
    Curr Med Res Opin 2018 Jan 16:1-17. Epub 2018 Jan 16.
    a Department of Pharmacy Practice , College of Pharmacy, University of Rhode Island , Kingston , RI , US.
    Objectives: Our study examined the impact of adherence to Novel Oral Anticoagulants (dabigatran and rivaroxaban) [NOACs] on ischemic-stroke (IS), major-bleeding (MB), deep-vein-thrombosis and pulmonary-embolism (DVTPE) risk in a large, nationwide, propensity-matched sample.

    Methods: A retrospective cohort study utilized data from a US commercial insurance database (2010-2012). Adults patients with ≥1 diagnosis of atrial fibrillation/flutter (ICD-9 427. Read More

    Lung Cancer Complicated With Asymptomatic Pulmonary Embolism: Clinical Analysis of 84 Patients.
    Technol Cancer Res Treat 2017 Dec 1;16(6):1130-1135. Epub 2017 Nov 1.
    1 Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China.
    Background And Objective: Pulmonary embolism is potentially life-threatening in patients with lung cancer, but the clinical studies on patients with lung cancer having asymptomatic pulmonary embolism were barely reported.

    Methods: Clinical data of patients with lung cancer were obtained from the Department of Respiratory and Critical Care Medicine of Tianjin Chest Hospital during July 2012 and June 2015 and were reviewed retrospectively. A total of 28 patients with lung cancer having pulmonary embolism (LP group) were enrolled, and another 56 cases with lung cancer alone (LC group) were enrolled as controls. Read More

    Quantitative CT Evaluation of Small Pulmonary Vessels in Patients with Acute Pulmonary Embolism.
    Acad Radiol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Radiology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki City, Kanagawa 216-8511, Japan.
    Rationale And Objectives: The objective of this study was to investigate the correlation between the computed tomography (CT) cross-sectional area (CSA) of small pulmonary vessels and the CT obstruction index in patients with acute pulmonary embolism (PE) and the correlation between the changes in these measurements after anticoagulant therapy.

    Materials And Methods: Fifty-two patients with acute PE were selected for this study. We measured the CSA less than 5 mm2 on coronal reconstructed images to obtain the percentage of the CSA (%CSA < 5). Read More

    Impact of Thrombus Sidedness on Presentation and Outcomes of Patients with Proximal Lower Extremity Deep Vein Thrombosis.
    Semin Thromb Hemost 2018 Jan 12. Epub 2018 Jan 12.
    Department of Internal Medicine, Universidad Católica de Murcia, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
    Small studies have suggested differences in demographics and outcomes between left- and right-sided deep vein thrombosis (DVT), and also unilateral versus bilateral DVT. We investigated the clinical presentation and outcomes of patients with DVT based on thrombus sidedness. The authors used the data from the Registro Informatizado Enfermedad TromboEmbólica (RIETE) database (2001-2016) to identify patients with symptomatic proximal lower-extremity DVT. Read More

    Association between ACE2/ACE balance and pneumocyte apoptosis in a porcine model of acute pulmonary thromboembolism with cardiac arrest.
    Mol Med Rep 2018 Jan 12. Epub 2018 Jan 12.
    Department of Emergency Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
    Acute pulmonary embolism (APE) is frequently reported in patients with cardiac arrest (CA) in emergency care. Pneumocyte apoptosis is commonly observed in the lungs following an APE. An important pathological mechanism evoking apoptosis during a lipopolysaccharide‑induced acute lung injury is the angiotensin‑converting enzyme 2 (ACE2)/ACE imbalance. Read More

    Catheter Assisted Management of Massive Pulmonary Embolism.
    J Assoc Physicians India 2017 Dec;65(12):105
    Professor and HOD, Department of Cardiology, Superspecialty Hospital, Nagpur, Maharashtra.
    Pulmonary thromboembolism is common and missed by clinicians. We report a case of massive pulmonary embolism which was life threatening treated by the catheter assisted technique. Anticoagulation is the mainstay of therapy for most patients, with thrombolytic therapy reserved for some patients. Read More

    Management of cancer-associated venous thromboembolism - a case-based practical approach.
    Vasa 2018 Jan 12:1-13. Epub 2018 Jan 12.
    1 Universitätsklinikum Eppendorf, Hamburg, Germany.
    In patients with solid tumours or haematological malignancies, venous thromboembolism (VTE) is a leading cause of death and significantly contributes to morbidity and healthcare resource utilization. Current practice guidelines recommend long-term anticoagulation with low-molecular-weight heparin (LMWH) as the treatment of choice for cancer-associated VTE, based on clinical trial data showing an overall improved safety and efficacy profile of LMWH compared to vitamin K antagonists. However, several open questions remain, e. Read More

    The impact of lung perfusion scintigraphy in the emergency management of patients with suspected pulmonary embolism.
    Hell J Nucl Med 2017 Sep-Dec;20 Suppl:166
    Nuclear Medicine Unit, D.I.M.-University of Bari "Aldo Moro", Bari, Italy.
    Objective: Pulmonary Embolism (PE) is an emergency condition that requires immediate treatment. As the symptoms and the risk factors are nonspecific, PE differential diagnosis is often required. Even if angio-CT is considered the gold standard for PE diagnosis, the frequent allergic condition and/or chronic renal failure of patients make, in most cases, not possible the use of contrast enhancement in emergency with even more increasing use of Lung Perfusion Scintigraphy (LPS), as a simple and fast examination with no preparation/contraindication. Read More

    Pulmonary embolism in the hospitalized patients 65+ in relation to presence of diabetes in 2007-2015.
    Adv Gerontol 2017 ;30(5):703-708
    Department of Internal Medicine,Geriatrics and Practical Medicine, Faculty Hospital Brno and Masaryk University, Jihlavska 20, Brno, 625 00, Czech Republic;
    The aim was to compare an occurrence of acute PE in hospitalized patients 65+ years old with diabetes mellitus (DM) with those without any DM. It was a retrospective analysis of data collected in documentation of patients who were hospitalized at the geriatric department in the years 2007-2015. In this period we had 11 947 patients of an average age of 79,9±8,5 years (min - 65, max - 103 years). Read More

    Catheter-directed, ultrasound-facilitated fibrinolysis in obese patients with massive and submassive pulmonary embolism.
    J Thromb Thrombolysis 2018 Jan 10. Epub 2018 Jan 10.
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
    Obesity is a well-established risk factor for pulmonary embolism (PE). However, treatment of PE in obese patients is challenging because of limited outcomes data, especially with advanced therapies such as catheter-based fibrinolysis. We assessed the efficacy and safety of ultrasound-facilitated, catheter-directed fibrinolysis in obese patients with submassive and massive PE enrolled in the SEATTLE II Trial. Read More

    Tenecteplase compared with streptokinase and heparin in the treatment of pulmonary embolism: an observational study.
    J Drug Assess 2017 3;6(1):33-37. Epub 2017 Jan 3.
    Department of Cardiology, Krishna Institute of Medical ScienceHyderabadIndia.
    Background: Thrombolytics are recommended in high risk patients with massive pulmonary embolism (PE). However, clinical practice seems to be far different and questions related to its utility in less severely affected patients remain the subject of investigation. The objective of this observational study was to compare the efficacy and safety of tenecteplase with streptokinase and heparin. Read More

    Pulmonary Embolism Caused by Intravenous Leiomyosarcoma of the Lower Limb.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Internal Medicine, Kitaibaraki City Hospital, Japan.
    Pulmonary embolism (PE) is usually caused by thrombosis or tumor. We report the long-term survival of a patient with PE due to a leiomyosarcoma in the deep vein. A 71-year-old woman complained of dyspnea and swelling of the left lower limb. Read More

    Factor V Leiden paradox in a middle-aged Swedish population: A prospective study.
    Vasc Med 2018 Jan 1:1358863X17745591. Epub 2018 Jan 1.
    2 Department of Clinical Sciences, Lund University, Malmö, Sweden.
    Few prospective studies have examined the factor V paradox: factor V Leiden (FVL) is a stronger risk factor for deep venous thrombosis (DVT) than for pulmonary embolism (PE). The present study, to the best of our knowledge, is the first population-based study aimed to examine the relationship between FVL and incidence of venous thromboembolism (VTE), DVT and PE in a prospective cohort study of middle-aged Swedish individuals. FVL was determined in 4890 subjects (aged 46-68 years, 57% women) from the general population without previous VTE or cancer, who participated in the Malmö Diet and Cancer study between 1991 and 1994. Read More

    Prevalence and Risk Factors of Acute Pulmonary Embolism in Patients with Lung Cancer Surgery.
    Semin Thromb Hemost 2018 Jan 10. Epub 2018 Jan 10.
    Department of General Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
    Acute pulmonary embolism (PE) is one of the serious complications with high mortality after thoracic surgery. The authors aimed to determine the prevalence of PE events and evaluate additional risk factors for PE in patients with lung cancer surgery. Patients underwent lung cancer resections during January 2012 to July 2015 and had 30-day postoperative follow-up were included. Read More

    The prognostic value of mid-regional pro-adrenomedullin in the evaluation of acute dyspnea.
    Expert Rev Mol Diagn 2018 Jan 19:1-7. Epub 2018 Jan 19.
    b Weill Cornell Medical College, Division of General Internal Medicine , New York-Presbyterian Hospital , New York , NY , USA.
    Introduction: Acute dyspnea is a common chief complaint among patients who visit an emergency room and presents diagnostic challenges for clinicians in both identifying the etiology and determining the clinical severity. The study of biomarkers in the prognostication and risk stratification of these patients has been increasing, including the investigation of the prognostic value for mid-regional pro-adrenomedullin (MR-proADM). Areas covered: In this review, the authors cover what is known about MR-proADM testing in patients presenting with acute dyspnea and the supporting evidence of its prognostic value in common conditions in medical patients with acute dyspnea, including acute heart failure, community acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease, and acute pulmonary embolism. Read More

    Venous Thromboembolism Within Professional American Sport Leagues.
    Orthop J Sports Med 2017 Dec 19;5(12):2325967117745530. Epub 2017 Dec 19.
    The Rothman Institute, Philadelphia, Pennsylvania, USA.
    Background: Numerous reports have described players in professional American sports leagues who have been sidelined with a deep vein thrombosis (DVT) or a pulmonary embolism (PE), but little is known about the clinical implications of these events in professional athletes.

    Purpose: To conduct a retrospective review of injury reports from the National Hockey League (NHL), Major League Baseball (MLB), the National Basketball Association (NBA), and the National Football League (NFL) to take a closer look at the incidence of DVT/PE, current treatment approaches, and estimated time to return to play in professional athletes.

    Study Design: Descriptive epidemiology study. Read More

    Safety Profile of Biosimilar Filgrastim (Zarzio/Zarxio): A Combined Analysis of Phase III Studies.
    Oncologist 2018 Jan 9. Epub 2018 Jan 9.
    Duke Cancer Institute, Durham, North Carolina, USA.
    Background: Evaluation of adverse events (AEs) in pivotal registration trials and ongoing postmarketing surveillance is important for all biologics, including biosimilars. A combined analysis of two pivotal registration studies was performed to strengthen evidence on safety for biosimilar filgrastim EP2006 in patients with breast cancer receiving myelosuppressive chemotherapy, a sensitive clinical setting to confirm biosimilarity of filgrastim.

    Materials And Methods: Data were combined from two phase III studies of biosimilar filgrastim EP2006. Read More

    Oxidized low density lipoprotein in inflammation-driven thrombosis.
    J Thromb Haemost 2018 Jan 6. Epub 2018 Jan 6.
    Dept. of Laboratory Medicine, Medical University of Vienna, Research Center for Molecular Medicine of the Austrian Academy of Sciences.
    Thrombosis is the defining feature of the most prevalent causes of cardiovascular mortality, such as myocardial infarction, stroke and pulmonary artery embolism. While platelet activation as well as activation of the plasmatic coagulation system are the hallmarks of thrombus formation, inflammatory processes and the cellular responses involved are increasingly recognized as critical modulators of thrombosis. In the context of many chronic inflammatory diseases that are associated with a high thrombotic risk, oxidized lipoproteins represent a prominent sterile trigger of inflammation. Read More

    Home versus in-patient treatment for deep vein thrombosis.
    Cochrane Database Syst Rev 2018 Jan 9;1:CD003076. Epub 2018 Jan 9.
    NHS Lothian, Directorate of Public Health and Health Policy, Waverly Gate, 2-4 Waterloo Place, Edinburgh, UK, EH1 3EG.
    Background: Deep vein thrombosis (DVT) occurs when a blood clot blocks blood flow through a vein, which can occur after surgery, after trauma, or when a person has been immobile for a long time. Clots can dislodge and block blood flow to the lungs (pulmonary embolism (PE)), causing death. DVT and PE are known by the term venous thromboembolism (VTE). Read More

    Ambulatory management of pulmonary embolism.
    Br J Hosp Med (Lond) 2018 Jan;79(1):18-25
    Consultant Physician and Clinical Director for Acute Medicine, Department of Acute Medicine, James Cook University Hospital, Middlesbrough TS4 3BW.
    The diagnosis of pulmonary embolism can be very difficult and elusive. It depends greatly on the use of diagnostic tests, which are in turn interpreted according to a pre-test clinical probability. These include non-specific tests such as the chest X-ray and electrocardiograph, which help exclude other conditions such as pneumonia or myocardial infarction. Read More

    Pathway and application value of exploration of the pulmonary artery by endobronchial ultrasound.
    J Thorac Dis 2017 Dec;9(12):5345-5351
    The 1st Department of Respiratory Medicine and Medical Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang 110004, China.
    Background: The current standard methods for detecting pulmonary artery diseases are pulmonary artery enhanced computed tomography (CT) scan and pulmonary arteriography. However, some patients cannot tolerate these procedures for various reasons. The present study aimed to investigate the feasibility and operation process of endobronchial ultrasound (EBUS) in exploring the pulmonary artery. Read More

    Retrospective review of the diagnosis and treatment of pulmonary sequestration in 28 patients: surgery or endovascular techniques?
    J Thorac Dis 2017 Dec;9(12):5153-5160
    Cardiothoracic Surgery Department, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
    Background: Pulmonary sequestration (PS) is a rare congenital pulmonary malformation. In this study, we aimed to retrospect and evaluate the diagnosis, treatment, and outcomes of PS in 28 patients at our institute.

    Methods: The files of 28 patients with PS who were treated with surgery (21 cases) or endovascular intervention (7 cases) between May 2005 and June 2016 from a single institute were retrospectively reviewed. Read More

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