1,233,468 results match your criteria Pulmonary Embolism


Ventilation/perfusion SPECT/CT in patients with severe and rigid scoliosis: An evaluation by relationship to spinal deformity and lung function.

Clin Neurol Neurosurg 2018 Dec 6;176:97-102. Epub 2018 Dec 6.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 37 Guoxue Rd, Chengdu, 610041, China. Electronic address:

Objective: Structural changes of the spine and chest wall associated with SRS result in poor cardiopulmonary function. Comprehensive assessment of pulmonary function is extremely important for patients with SRS before a correction operation. We explore the changes of distribution of lung ventilation and perfusion function in patients with SRS using SPECT/CT and describe the relation between these changes with Cobb angle and FVC%. Read More

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December 2018

Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism.

Thromb Res 2018 Dec 6;174:40-47. Epub 2018 Dec 6.

Center for Molecular Cardiology, Laboratory for Platelet Research, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland. Electronic address:

Introduction: Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events including myocardial infarction and stroke, and mortality. However, the association of TMAO with recurrent venous thromboembolism (VTE) and mortality remains unknown.

Methods: TMAO plasma levels were assessed by high performance liquid chromatography in 859 patients aged ≥65 years with acute VTE and categorized into low (<2. Read More

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December 2018
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Prescription patterns of direct oral anticoagulants in pulmonary embolism: A prospective multicenter French registry.

Thromb Res 2018 Dec 8;174:27-33. Epub 2018 Dec 8.

Department of Cardiology, EA3920, University Hospital Besançon, Boulevard Fleming, 25030 Besançon, France. Electronic address:

Background: Data regarding the use of direct oral anticoagulants (DOACs) for the treatment of acute pulmonary embolism (PE) are sparse. We conducted a prospective multicentre registry study to describe patterns of DOAC prescription for the treatment of acute PE, and the associated risk of 6-month adverse events in daily practice.

Methods: We included all PE patients discharged since the availability of DOACs for the dedicated indication of acute PE treatment. Read More

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December 2018

Bubble-free rapid microfluidic PCR.

Biosens Bioelectron 2018 Oct 11;126:725-733. Epub 2018 Oct 11.

Department of Bioengineering, University of California Berkeley, CA 94720, USA; Berkeley Sensor and Actuator Center, University of California Berkeley, CA 94720, USA; UC Berkeley and UCSF Joint Graduate Program in Bioengineering, Berkeley/San Francisco, USA; Department of Electrical Engineering and Computer Science, University of California Berkeley, CA 94720, USA; Biophysics Graduate Program, University of California Berkeley, CA 94720, USA. Electronic address:

Microfluidic polymerase chain reaction (PCR) has been of great interest owing to its ability to perform rapid and specific nucleic acid amplification and analysis on small volumes of samples. One of the major drawbacks of microfluidic PCR is bubble generation and reagent evaporation, which can cause malfunctions. Here, through theoretical modeling and characterization of bubble behavior, we propose a bubble-free microfluidic PCR device via controlled fluid transfer. Read More

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October 2018
1 Read

Triphenyltin(IV) acylhydrazone compounds: Synthesis, structure and bioactivity.

J Inorg Biochem 2018 Nov 24;191:194-202. Epub 2018 Nov 24.

Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China. Electronic address:

Four new triphenyltin(IV) acylhydrazone compounds of the type PhSnCHCHCONHN=R (where Ph = phenyl; R = isopropyl, isobutyl, cyclopentyl and cyclooctyl) were synthesized and characterized by elemental analysis, infrared spectrum (IR), nuclear magnetic resonance spectrum (NMR) and mass spectrum (MS). The crystal structures were determined and showed that tin atoms were four-coordinated and adopted a pseudo-tetrahedron configuration. Tin(IV) compounds show excellent bovine serum albumin (BSA) binding properties, and can oxidize nicotinamide-adenine dinucleotid (NADH) to generate reactive oxygen species (ROS), which inducing apoptosis effectively. Read More

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November 2018

Detection of engraftment of donor-derived antibody producing cells in a lung transplant recipient by anti-cytomegalovirus IgG avidity test.

Transpl Immunol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima 960-1295, Japan.

Transplant recipients become immunocompromised through the use of immunosuppressive therapy to prevent allograft rejection. These recipients readily experience human cytomegalovirus (CMV) infection or reactivation. Therefore, CMV represents a life-threatening pathogen in transplant recipients. Read More

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December 2018

Anthriscus sylvestris root extract reduces allergic lung inflammation by regulating interferon regulatory factor 4-mediated Th2 cell activation.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Korea; Department of Pathology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, 26339, Korea. Electronic address:

Ethnopharmacological Relevance: Anthriscus sylvestris L. Hoffmann (AS) is a perennial plant that grows in Asia and Eastern Europe. Its dried root is used to treat conditions such as asthma, bronchitis, and cough. Read More

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December 2018
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The Microbiome in Asthma: Role in pathogenesis, phenotype, and response to treatment.

Ann Allergy Asthma Immunol 2018 Dec 12. Epub 2018 Dec 12.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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December 2018

The clinicopathologic impacts and prognostic significance of GLUT1 expression in patients with lung cancer: A meta-analysis.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Department of Thoracic Oncology, First Affiliated Hospital of Xi'an Medical College, Xi'an 710032, Shaanxi Province, PR China. Electronic address:

Background: Accumulating studies have reported that GLUT1 is aberrantly expressed in lung cancer; nevertheless, the clinicopathologic significance and the prognostic role of GLUT1 still remain controversial. The aim of this meta-analysis was to identify the clinicopathologic and prognostic implications of the GLUT1 expression in lung cancer patients.

Materials And Methods: Databases with literature published in English, including Cochrane Library, Embase, Web of Science, and PubMed, and the China National Knowledge Infrastructure (CNKI) and WanFang database in Chinese were searched comprehensively for relevant studies in August 2017. Read More

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December 2018

Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring in- and out-of-field.

Int J Radiat Oncol Biol Phys 2018 Dec 12. Epub 2018 Dec 12.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland, UK.

Purpose: The aim of this study was to define the dose and dose-volume relationship of radiation induced pulmonary toxicities occurring in and out-of-field in mouse models of early inflammatory and late fibrotic response.

Materials And Methods: Early radiation induced inflammation and fibrosis were investigated in C3H/NeJ and C57BL/6J mice respectively. Animals were irradiated with 20 Gy delivered to the upper region of the right lung as a single fraction or as three consecutive fractions using the Small Animal Radiation Research Platform (SARRP, Xstrahl Inc. Read More

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December 2018

Superparamagnetic Iron Oxides as MPI Tracers: A Primer and Review of early applications.

Authors:
J W M Bulte

Adv Drug Deliv Rev 2018 Dec 12. Epub 2018 Dec 12.

Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Department of Chemical & Biomolecular Engineering, Department of Biomedical Engineering, and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Magnetic particle imaging (MPI) has recently emerged as a non-invasive, whole body imaging technique that detects superparamagnetic iron oxide (SPIO) nanoparticles similar as those used in magnetic resonance imaging (MRI). Based on tracer "hot spot" detection instead of providing contrast on MRI scans, MPI has already proven to be truly quantitative. Without the presence of endogenous background signal, MPI can also be used in certain tissues where the endogenous MRI signal is too low to provide contrast. Read More

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December 2018

Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: the effect of NOD2/CARD15 mutations in a Tunisian population.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Immunogenetic Applied to Cells Therapy Research Unit, Immuno-Haematology and HLA-Typing Department, National Blood Transfusion Centre of Tunis, Tunis, Tunisia.

Bronchiolitis obliterans (BO) is a serious lung complication that can develop after allogenic stem cell transplantation. It has been suggested that single nucleotide polymorphisms (SNPs) that affect the NOD2/CARD15 gene impair its function and result in an uncontrolled innate immune response in the recipient, thereby leading to BO. One hundred eighty-one donor-recipient pairs were analyzed for the association between NOD2 gene variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) and the occurrence of BO. Read More

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December 2018

Open Thoracoabdominal Aortic Aneurysm Repair: Contemporary Outcomes for 393 Elective Cases.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Japan.

Background: The purpose of this study was to reveal the mid- and long-term mortality rates among patients with thoracoabdominal aortic aneurysm (TAAA) following open TAAA repair (TAAAR) and to clarify the impact of aneurysm type on mortality.

Methods: We retrospectively analyzed data for 393 patients (290 males; age, 63.2 ± 12. Read More

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December 2018
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Darpp-32 and t-Darpp protein products of PPP1R1B: old dogs with new tricks.

Biochem Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry and Biochemistry, California State University, Los Angeles, CA, USA. Electronic address:

The PPP1R1B gene is located on chromosome 17q12 (39,626,208-39,636,626[GRCh38/hg38]), which codes for multiple transcripts and two experimentally-documented proteins Darpp-32 and t-Darpp. Darpp-32 (Dopamine and cAMP Regulated Phosphoprotein), discovered in the early 1980s, is a protein whose phosphorylation is upregulated in response to cAMP in dopamine-responsive tissues in the brain. It's phosphorylation profile modulates its ability to bind and inhibit Protein Phosphatase 1 activity, which, in turn, controls the activity of hundreds of phosphorylated proteins. Read More

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December 2018
2 Reads

Performance, Long Term Management, and Coding for Percutaneous Dilational Tracheostomy.

Chest 2018 Dec 12. Epub 2018 Dec 12.

Trauma, Critical Care and Surgery, Carolinas Medical Center, Charlotte, NC 28203.

Percutaneous dilatational tracheotomy (PDT) has become increasingly popular and gained widespread acceptance. The modern PDT procedure has also evolved to whereby it can be safely performed by surgeons and non-surgeons in the intensive care unit (ICU). Moreover, bedside PDT has proven clinical outcomes and can save hospital resources. Read More

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December 2018

First report of two consecutive respiratory syncytial virus outbreaks by the novel genotypes ON-1 and NA-2 in a neonatal intensive care unit.

J Pediatr (Rio J) 2018 Dec 12. Epub 2018 Dec 12.

Santa Casa de São Paulo, Unidade de Doenças Infecciosas Pediátricas, São Paulo, SP, Brazil.

Objective: Respiratory syncytial virus is a pathogen frequently involved in nosocomial outbreaks. Although several studies have reported nosocomial outbreaks in neonatal intensive care units, molecular epidemiology data are scarce. Here, the authors describe two consecutive respiratory syncytial virus outbreaks caused by genotypes ON-1 and NA-2 in a neonatal intensive care unit in São Paulo, Brazil. Read More

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December 2018

Effects of proton pump inhibitors on severe haematotoxicity induced after first course of pemetrexed/carboplatin combination chemotherapy.

J Clin Pharm Ther 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Applied Therapeutics, Center for Education & Research on Clinical Pharmacy, Showa Pharmaceutical University, Tokyo, Japan.

What Is Known And Objective: Pemetrexed/carboplatin combination chemotherapy has shown efficacy as a first-line treatment for advanced non-small-cell lung cancer. However, severe haematotoxicity is often observed during this combination chemotherapy. Some studies have suggested that concomitant drugs may be the risk factors for severe adverse events. Read More

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December 2018
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Diagnostic diversity - an indicator of institutional and regional healthcare quality.

Swiss Med Wkly 2018 Dec 15;148:w14691. Epub 2018 Dec 15.

Lung Centre, Cantonal Hospital St Gallen, Switzerland.

Aim: Our aim was to estimate the diagnostic performance of institutions and healthcare regions from a nationwide hospitalisation database.

Methods: The Shannon diversity index was used as an indicator of diagnostic performance based on the International Classification of Disease, 10th revision, German Modification (ICD-10-GM codes). The dataset included a total of 9,325,326 hospitalisation cases from 2009 to 2015 and was provided by the Swiss Federal Office for Statistics. Read More

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December 2018

Ulnar Artery Occlusion and severity markers of vasculopathy in Systemic sclerosis: a multicenter cross-sectional study.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Internal Medicine and Clinical Immunology, CHU Rennes, Univ Rennes, France.

Objective: to evaluate the association of ulnar artery occlusion (UAO) assessed by Doppler Ultrasonography (dUS) with the severity markers of systemic sclerosis (SSc) METHODS: 204 unselected patients fulfilling 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional multicenter study. All patients benefit from bilateral hand dUS evaluating the presence of UAO and clinical/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were conducted, grading the severity of UAO as "no UAO", "only one UAO" and "UAO on both hands" and assessing its association with clinical features of SSc. Read More

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December 2018
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Comparative risk of venous thromboembolism with tofacitinib versus tumor necrosis factor inhibitors: A cohort study of rheumatoid arthritis patients.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

Objective: To evaluate the risk of venous thromboembolism (VTE) with tofacitinib versus tumor necrosis factor (TNF)-inhibitors in rheumatoid arthritis (RA) patients.

Methods: RA patients initiating tofacitinib or a TNF inhibitor without use of any biologic or tofacitinib any time prior were identified from Truven MarketScan (2012-2016) or Medicare claims (parts A, B, and D, 2012-2015) and followed until treatment discontinuation, treatment switch, insurance disenrollment, or administrative censoring. The outcome of VTE was identified using inpatient claims for pulmonary embolism or deep vein thrombosis. Read More

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December 2018

SIRT4 Depletion Promotes HCC Tumorigenesis through Regulating AMPKα/mTOR Axis.

Hepatology 2018 Dec 15. Epub 2018 Dec 15.

Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, Berkeley, California, USA.

Sirtuin 4 (SIRT4) has been reported to play a vital role in the maintenance of glutamine catabolism and ATP homeostasis, but its character in hepatocellular carcinomas (HCCs) remains obscure. In this study, we observed low expression of SIRT4 in both HCC cell lines and HCCs from patients. Decreased disease-free survival time is associated with low tumor levels of SIRT4 in patients. Read More

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December 2018

Cytohistological correlation, immunohistochemistry and Murine Double Minute Clone 2 amplification of pulmonary artery intimal sarcoma: A case report with review of literature.

Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.

Pulmonary artery intimal sarcoma is a rare aggressive intraluminal tumor often misdiagnosed as acute or chronic pulmonary thromboembolism due to its clinical presentation and radiological findings. Thus early diagnosis is very crucial and may improve patient outcome. There is limited literature on diagnosis of pulmonary artery sarcoma by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Read More

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December 2018

FDA jeopardizes the lives of lung transplant recipients and in the process severely increases the cost to develop new immunosuppression.

Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Duke University, Durham, NC, USA.

On January 1, 2018, Medicare Part D insurers implemented a new rule that seriously affects immunosuppression in lung transplant recipients. The program is now following the directive of the US Food and Drug Administration (FDA) that no drug should be dispensed or be covered by insurance for any indications other than those approved by the FDA (1, 2). That excludes the use of mycophenolate (CellCept and Myfortic) and azathioprine (Imuran) for lung transplant recipients. Read More

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December 2018

Dose prescription with spatial uncertainty for peripheral lung SBRT.

J Appl Clin Med Phys 2018 Dec 14. Epub 2018 Dec 14.

Joint Department of Physics, The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, London, UK.

Current clinical practice is to prescribe to 95% of the planning target volume (PTV) in 4D stereotactic body radiotherapy (SBRT) for lung. Frequently the PTV margin has a very low physical density so that the internal target volume (ITV) receives an unnecessarily high dose. This study investigates the alternative of prescribing to the ITV while including the effects of positional uncertainties. Read More

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December 2018

Periventricular Microglial Cells Interact with Dividing Precursor Cells in the Nonhuman Primate and Rodent Prenatal Cerebral Cortex.

J Comp Neurol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, School of Medicine, UC Davis, Davis, CA.

Cortical proliferative zones have been studied for over 100 years, yet recent data has revealed that microglial cells constitute a sizeable proportion of ventricular zone cells during late stages of cortical neurogenesis. Microglia begin colonizing the forebrain after neural tube closure and during later stages of neurogenesis populate regions of the developing cortex that include the proliferative zones. We previously showed that microglia regulate the production of cortical cells by phagocytosing neural precursor cells (NPCs), but how microglia interact with NPCs remains poorly understood. Read More

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December 2018

Specific features of immune complexes in patients with sarcoidosis and pulmonary tuberculosis.

Immunol Res 2018 Dec 14. Epub 2018 Dec 14.

FGBU "St. Petersburg Scientific Research Institute of Phthisiopulmonology" of the Ministry of Health of Russia, St. Petersburg, Russia.

Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of tuberculosis. Read More

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December 2018
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Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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December 2018

Radiologic types of Mycobacterium xenopi pulmonary disease: different patients with similar short-term outcomes.

Eur J Clin Microbiol Infect Dis 2018 Dec 14. Epub 2018 Dec 14.

Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Mycobacterium xenopi pulmonary disease (Mxe-PD) is common among nontuberculous mycobacterial infections in Europe and Canada. Associations between radiological pattern and clinical features and outcomes are inadequately studied in Mxe-PD. We sought to investigate clinical characteristics and outcomes according to the dominant radiological pattern among patients with Mxe-PD. Read More

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December 2018

Role of Antigen Type in Survival in Chronic Hypersensitivity Pneumonitis.

Lung 2018 Dec 14. Epub 2018 Dec 14.

Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA.

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December 2018

[Image-based screening].

Authors:
G Layer

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Zentralinstitut für Diagnostische und Interventionelle Radiologie, Klinikum Ludwigshafen gGmbH, Bremserstraße 79, 67063, Ludwigshafen, Deutschland.

Screening is a special issue in medical questions concerning disease prevention. Preconditions for screening are clearly defined by the World Health Organization. High prevalence, effectiveness of therapy, availability of accepted test procedure and consensus concerning the economic concerns are necessary for successful implementation of a screening program. Read More

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December 2018

[Mimics of lung cancer].

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Institut für Röntgendiagnostik, Otto-Wagner-Spital, Baumgartner Höhe 1, 1140, Wien, Österreich.

Lung cancer is a histologically, immunologically and therefore morphologically and functionally very heterogeneous group of neoplasms with the highest cancer mortality worldwide. Therefore, the range of diseases mimicking lung cancer is also very broad and includes congenital, infectious and inflammatory changes as well as other benign space-occupying lesions and other primary and secondary pulmonary neoplasms. The difficulty in radiology lies in the ability to diagnose lung cancer with a high degree of certainty. Read More

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December 2018

Time-series hyperpolarized xenon-129 MRI of lobar lung ventilation of COPD in comparison to V/Q-SPECT/CT and CT.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, OX3 7DQ, Oxford, UK.

Purpose: To derive lobar ventilation in patients with chronic obstructive pulmonary disease (COPD) using a rapid time-series hyperpolarized xenon-129 (HPX) magnetic resonance imaging (MRI) technique and compare this to ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT), correlating the results with high-resolution computed tomography (CT) and pulmonary function tests (PFTs).

Materials And Methods: Twelve COPD subjects (GOLD stages I-IV) participated in this study and underwent HPX-MRI, V/Q-SPECT/CT, high-resolution CT, and PFTs. HPX-MRI was performed using a novel time-series spiral k-space sampling approach. Read More

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December 2018

Longitudinal airway remodeling in active and past smokers in a lung cancer screening population.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Objectives: To longitudinally investigate smoking cessation-related changes of quantitative computed tomography (QCT)-based airway metrics in a group of heavy smokers.

Methods: CT scans were acquired in a lung cancer screening population over 4 years at 12-month intervals in 284 long-term ex-smokers (ES), 405 continuously active smokers (CS), and 31 subjects who quitted smoking within 2 years after baseline CT (recent quitters, RQ). Total diameter (TD), lumen area (LA), and wall percentage (WP) of 1st-8th generation airways were computed using airway analysis software. Read More

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December 2018

Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Exposure to environmental chemicals has been shown to have an impact on the epigenome. One example is a known human carcinogen 1,3-butadiene which acts primarily by a genotoxic mechanism, but also disrupts the chromatin structure by altering patterns of cytosine DNA methylation and histone modifications. Sex-specific differences in 1,3-butadiene-induced genotoxicity and carcinogenicity are well established; however, it remains unknown whether 1,3-butadiene-associated epigenetic alterations are also sex dependent. Read More

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December 2018

Refining AML outcome prediction.

Leukemia 2018 Dec 14. Epub 2018 Dec 14.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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December 2018

Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury.

Sci Rep 2018 Dec 14;8(1):17870. Epub 2018 Dec 14.

UW Medicine South Lake Union, University of Washington, Seattle, WA, 98109, USA.

Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late phases of a pathologic continuum of interconnected disease states. Although changes in gene expression patterns have recently been elucidated for the transition of AKI to CKD, the epigenetic regulation of key kidney injury related genes remains poorly understood. We used multiplex RT-qPCR, ChIP-qPCR and integrative analysis to compare transcriptional and epigenetic changes at renal disease-associated genes across mouse AKI and CKD models. Read More

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December 2018

miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs.

Lab Invest 2018 Dec 14. Epub 2018 Dec 14.

Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.

Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptors (EGFR) significantly prolong the survival of lung adenocarcinoma patients with sensitizing EGFR mutations. Unfortunately, 10-30% patients do not show objective responses to EGFR-TKIs, and undergo rapid disease progression during the EGFR-TKIs therapy. Single nucleotide polymorphisms (SNPs) in mature microRNA (miRNA) sequences may influence target site interactions and modulate downstream pathways, such as the EGFR pathway. Read More

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December 2018

Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.

Nat Commun 2018 Dec 14;9(1):5331. Epub 2018 Dec 14.

Posttranscriptional Gene Regulation, Cancer Research and Experimental Haemostasis, University Medical Centre Mainz, Mainz, 55131, Germany.

Diversification at the transcriptome 3'end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3'end-alterations in neuroblastoma, a tumour entity with a paucity of recurrent somatic mutations and an unusually high frequency of spontaneous regression. Utilising extensive RNAi-screening we reveal the landscape and drivers of transcriptome 3'end-diversification, discovering PCF11 as critical regulator, directing alternative polyadenylation (APA) of hundreds of transcripts including a differentiation RNA-operon. Read More

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December 2018

Risk factors for opioid-induced respiratory depression in surgical patients: a systematic review and meta-analyses.

BMJ Open 2018 Dec 14;8(12):e024086. Epub 2018 Dec 14.

Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: This systematic review and meta-analysis aim to evaluate the risk factors associated with postoperative opioid-induced respiratory depression (OIRD).

Design: Systematic review and meta-analysis.

Data Sources: PubMed-MEDLINE, MEDLINE in-process, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, PubMed and Clinicaltrials. Read More

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December 2018
2.063 Impact Factor

Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study.

BMJ Open 2018 Dec 14;8(12):e023853. Epub 2018 Dec 14.

Surgery, School of Medicine, University of Edinburgh, Edinburgh, UK.

Introduction: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.

Objective: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP.

Design: Cohort study. Read More

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December 2018

CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.

Mol Cancer Res 2018 Dec 14. Epub 2018 Dec 14.

Institute of Physiology, University of Zurich

Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation; but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Read More

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December 2018

The key protein of endosomal mRNP transport Rrm4 binds translational landmark sites of cargo mRNAs.

EMBO Rep 2018 Dec 14. Epub 2018 Dec 14.

Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University Frankfurt, Frankfurt am Main, Germany

RNA-binding proteins (RBPs) determine spatiotemporal gene expression by mediating active transport and local translation of cargo mRNAs. Here, we cast a transcriptome-wide view on the transported mRNAs and cognate RBP binding sites during endosomal messenger ribonucleoprotein (mRNP) transport in Using individual-nucleotide resolution UV crosslinking and immunoprecipitation (iCLIP), we compare the key transport RBP Rrm4 and the newly identified endosomal mRNP component Grp1 that is crucial to coordinate hyphal growth. Both RBPs bind predominantly in the 3' untranslated region of thousands of shared cargo mRNAs, often in close proximity. Read More

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December 2018

Understanding the principle biophysics concepts of pulmonary surfactant in health and disease.

Arch Dis Child Fetal Neonatal Ed 2018 Dec 14. Epub 2018 Dec 14.

Department of Biochemistry and Molecular Biology, Faculty of Biology, Complutense University, Madrid, Spain.

Pulmonary surfactant (PS) is a lipid-protein complex essential to stabilise the delicate structure of mammalian alveoli along with successive compression-expansion respiratory cycles. To do so, surfactant reduces dramatically surface tension at the air-liquid interface, an activity that depends critically on a proper lipid composition and the presence of some specific surfactant proteins. Lack or dysfunction of this system is associated with severe respiratory pathologies, which are in some cases treated by supplementation with exogenous surfactant materials. Read More

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December 2018

An overview of the 6th World Symposium on Pulmonary Hypertension.

Eur Respir J 2018 Dec 14. Epub 2018 Dec 14.

Univ. Paris-Sud, AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Service de Pneumologie, Département Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Hôpital de Bicêtre, Le Kremlin Bicêtre, France.

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December 2018

Smaller erector spinae muscle size is associated with inability to recover activities of daily living after pneumonia treatment.

Respir Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address:

Background: Elderly patients who are hospitalized due to pneumonia experience deterioration of their activities of daily living (ADL) during this period; in some cases, this loss of ADL is not recovered at the end of antibiotic treatment. In this study, we examined whether erector spinae muscle cross-sectional area (ESMCSA) measured by computed tomography (CT) could predict a low level of ADL at the end of antibiotic treatment for pneumonia.

Methods: Eighty patients (mean age 74. Read More

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December 2018

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Lancet Respir Med 2018 Dec 11. Epub 2018 Dec 11.

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address:

Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.

Methods: In this genome-wide association study, we used a two-stage case-control design. Read More

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December 2018

Early onset children's interstitial lung diseases: Discrete entities or manifestations of pulmonary dysmaturity?

Paediatr Respir Rev 2018 Oct 9. Epub 2018 Oct 9.

Department of Histopathology, Royal Brompton & Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.

Interstitial lung diseases in children (chILD) are rare and diverse. The current classifications include a group of early onset chILD specific to infancy, namely neuro-endocrine cell hyperplasia of infancy (NEHI), pulmonary interstitial glycogenosis (PIG) and the alveolar capillary-congenital acinar dysplasia (ACD-CAD) spectrum, as well as alveolar growth disorders. NEHI and PIG cells are seen in the normal developing foetal lung. Read More

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October 2018

Optimization of patient-specific inhaler regimens with the use of the aerosol inhalation monitor.

J Am Pharm Assoc (2003) 2018 Dec 11. Epub 2018 Dec 11.

Objectives: To describe the addition of a Vitalograph Aerosol Inhalation Monitor (AIM) assessment to a pharmacy bundle to optimize inhaler devices in patients with asthma and chronic obstructive pulmonary disease (COPD).

Setting: Hospital-based outpatient pulmonary clinic.

Practice Description: Ambulatory pharmacy service for underserved pulmonary patients in Detroit, MI. Read More

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December 2018

Towards a tailored cryo-pulmonary vein isolation. Lessons learned from second-generation cryoballoon ablation.

Trends Cardiovasc Med 2018 Nov 16. Epub 2018 Nov 16.

Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, Belgium.

Second-generation cryoballoon ablation has emerged as an effective and practical approach for the treatment of atrial fibrillation. It gained the overall interest of the electrophysiology community due to its excellent success rates, and reproducible clinical outcomes comparable to the point-by-point radiofrequency technique. This technology offers several advantages including a fast learning curve and shorter procedure times making this device widely adopted in many EP-laboratories as an alternative strategy to conventional point-by-point radiofrequency ablation. Read More

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November 2018

Characterization of Right Ventricular Deformation in Pulmonary Arterial Hypertension Using Three-Dimensional Principal Strain Analysis.

J Am Soc Echocardiogr 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada. Electronic address:

Background: Pulmonary arterial hypertension (PAH) can cause maladaptive right ventricular (RV) functional changes associated with adverse prognosis that are challenging to accurately quantify noninvasively. The aim of this study was to explore principal strain (PS) with contraction angle analysis using three-dimensional echocardiography to characterize RV deformation changes in patients with PAH.

Methods: Three-dimensional echocardiography was performed in 37 patients with PAH and 20 healthy control subjects with two-component (primary and secondary) PS and principal contraction angle analysis. Read More

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December 2018
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