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J Assoc Physicians India 2022 May;70(5):11-12

Resident, SKIMS, Srinagar, Jammu and Kashmir.

Aims And Objectives: Patients with pulmonary thromboembolism (PTE) are commonly admitted to hospital and generally have a prolonged hospital stay in this part of the world. We aimed to determine different clinical and laboratory parameters that are associated with prolonged hospital stay in our set-up and to analyse effectiveness of Pulmonary Embolism Severity Index (PESI) score as a predictor of prolonged hospital stay in patients with PTE.

Materials And Methods: It was a hospital based observational prospective study. Read More

J Obstet Gynaecol Res 2022 May 20. Epub 2022 May 20.

Department of Gynecologic Oncology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

Objective: To evaluate the open abdomen technique (laparostomy) used in complications of major gynecological oncology surgery.

Methods: We analyzed retrospectively the surgical database of all patients who had undergone major open surgery by the same gynecologic oncologist over a 5-year period. All patients who had had open abdomen procedure were identified; demographic data and indications of primary surgery, temporary abdominal closure procedure details, fascia closure and morbidity, mortality rates were evaluated. Read More

Thromb Res 2022 May 17;215:19-29. Epub 2022 May 17.

Nottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, NG7 2UH, UK. Electronic address:

Background And Aims: Historically, bleeding was thought to be a frequent and fatal complication of liver disease. However, thrombosis due to coagulation disorders in cirrhosis remains a real risk. We aim to systematically analyse published articles to evaluate epidemiology of venous thromboembolism (VTE) in chronic liver disease (CLD). Read More

J Exp Orthop 2022 May 20;9(1):47. Epub 2022 May 20.

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Purpose: Patients undergoing knee surgery are at high risk for deep vein thrombosis (DVT), which is infrequent but potentially life-threatening. It has not been identified how to efficiently detect high-risk DVT while minimizing bleeding complications from anticoagulation. We hypothesized that the degree of activation of thrombotic markers may correlate with the size of the thrombus. Read More

Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221102940

Internal Medicine Department, 150244Hospital Universitario La Samaritana, Bogota, Colombia.

Objective: To evaluate the discriminative ability and the calibration of the Pulmonary Embolism Severity Index (PESI) to predict in-hospital mortality in patients with Pulmonary Embolism (PE) secondary to COVID 19 in two hospitals in Bogotá.

Methods: External validation study of a prediction model based on a retrospective cohort of patients with PE secondary to COVID-19 treated at Hospital Universitario San Ignacio and Hospital universitario La Samaritana, between March 2020 and August 2021. Calibration of the scale was evaluated using the Hosmer-Lemeshow test and a calibration belt diagram. Read More

Front Pediatr 2022 3;10:877637. Epub 2022 May 3.

Division of Cardiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, United States.

The purpose of this study was to describe the demographics and in-hospital mortality of children (<18 years) from 2007 to 2018 supported by Extracorporeal Membrane Oxygenation (ECMO) for a primary diagnosis of pulmonary embolism and reported to the Extracorporeal Life Support Organization database. Fifty-six patients were identified and 54 were included in this analysis. A total of 33 patients (61%) survived. Read More

Clin Case Rep 2022 May 12;10(5):e05821. Epub 2022 May 12.

Department of Cardiovascular Medicine School of Medicine Shiraz University of Medical Sciences Shiraz Iran.

Aside from typical pneumonia, the coronavirus disease 2019 (COVID-19) has shown several extra-pulmonary manifestations. This study was done on a 66-year-old male patient who concomitantly had endogenous endophthalmitis and left ventricular thrombosis one month after being hospitalized due to COVID-19. Read More

Eur Spine J 2022 May 19. Epub 2022 May 19.

Department of Neurological Surgery, Division of Spine, Duke University, Box 3087, Durham, NC, USA.

Purpose: Prone transpsoas fusion (PTP) is a minimally invasive technique that maximizes the benefit of lateral access interbody surgery and the prone positioning for surgically significant adjacent segment disease. The authors describe the feasibility, reproducibility and radiographic efficacy of PTP when performed for cases of lumbar ASD.

Methods: Adult patients undergoing PTP for treatment of lumbar ASD at three institutions were retrospectively enrolled. Read More

Surgeon 2022 May 16. Epub 2022 May 16.

Department of Vascular Surgery, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.

Objective: A systematic review and meta-analysis was performed to determine the role of thromboprophylaxis in the prevention of venous thromboembolism in patients undergoing varicose vein interventions.

Methods: PUBMED, EMBASE and Web of Science were searched for comparative studies of patients undergoing varicose vein interventions and received either thromboprophylaxis or no thromboprophylaxis. Data were collected on the number of thrombotic events including deep vein thrombosis (DVT), pulmonary embolism (PE) and endothermal heat-induced thrombosis (EHIT) as well as bleeding events. Read More

Int J Spine Surg 2022 May 19. Epub 2022 May 19.

Department of Neurosurgery, Medical Trust Hospital, Kochi, Kerala, India.

Objective: In this article, the authors systematically evaluated the efficacy and safety of tranexamic acid (TXA) in surgeries for spinal trauma.

Methods: Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE, PubMed, and Google Scholar. Secondary sources were identified from the references of the included literature. Read More

Am Heart J 2022 May 16. Epub 2022 May 16.

Center for Thrombosis and Heamostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Department of Cardiology, Democritus University of Thrace, Greece. Electronic address:

Background: Due to the bleeding risk of full-dose systemic thrombolysis and the lack of major trials focusing on the clinical benefits of catheter-directed treatment, heparin antiocoagulation remains the standard of care for patients with intermediate-high-risk pulmonary embolism (PE).

Methods: The Higher-Risk Pulmonary Embolism Thrombolysis (HI-PEITHO) study (ClinicalTrials.gov Identifier: NCT04790370) is a multinational multicenter randomized controlled parallel-group comparison trial. Read More

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Department of Pathology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, China. Electronic address:

Background: Deep venous thrombosis (DVT) is a thrombus formed in the deep venous cavity and can cause a fatal pulmonary embolism. Since circulating miRNAs are used as molecular markers for the early warning and diagnosis of various diseases, such as tumors and cardiovascular diseases, the purpose of the present study was initially to identify differential expression circulating miRNAs in plasma, and then explore potential biomarkers for DVT.

Methods: The plasma of 30 patients with DVT before and after DVT related endovascular interventions constituted 6 sample pools for miRNA sequencing, and the levels of 22 plasma miRNAs were significantly changed. Read More

J Thromb Haemost 2022 May 19. Epub 2022 May 19.

Division of Internal Medicine, Department of Medicine, McGill University, Montreal, QC, Canada.

Background: Patients with cancer-associated thrombosis (CAT) are treated with full-dose anticoagulation for at least three months, but optimal dosing thereafter is unknown.

Aim: We explored the feasibility of extended prophylactic-dose low-molecular-weight heparin (LMWH) treatment following a minimum of three months of full-dose LMWH.

Methods: We conducted a multicenter prospective pilot study of patients with CAT who completed at least three months of therapeutic-dose LMWH. Read More

Cureus 2022 Apr 15;14(4):e24162. Epub 2022 Apr 15.

Internal Medicine, University of Hawaii, Honolulu, USA.

Introduction: Cirrhosis is a significant cause of mortality and morbidity worldwide. Recent studies suggested that cirrhosis is associated with an increased risk of venous thromboembolism (VTE), which disproves the old belief that chronic liver disease coagulopathy is considered protective against VTE. We conducted a retrospective study which is to our knowledge the first of its kind to assess clinical characteristics and outcomes of decompensated cirrhosis (DC) patients admitted with acute pulmonary embolism (APE). Read More

J Saudi Heart Assoc 2022 18;34(2):70-71. Epub 2022 Apr 18.

Department of Cardiology, Bahrain Defence Force Royal Medical Service, Mohammed Bin Khalifa Cardiac Centre (MKCC), Riffa, Kingdom of Bahrain.

J Perinat Med 2022 May 19. Epub 2022 May 19.

Department for Gynecology, Obstetrics and Gynecological Endocrinology, Kepler University Hospital Linz, Johannes Kepler University Linz, Linz, Austria.

Venous thromboembolism (VTE) is one of the leading causes of direct maternal deaths. It has been estimated that approximately 50% of these deaths are potentially preventable. The UK Confidential Enquiries into Maternal Deaths and the National Partnership for Maternal Safety have proposed strategies for the prevention of maternal deaths from VTE based on current guideline recommendations. Read More

Eur J Intern Med 2022 May 15. Epub 2022 May 15.

Emergency Department, Hospital Clínic, IDIBAPS, Barcelona, Catalonia, Spain.

Clin Med (Lond) 2022 May;22(3):290

Dr DY Patil University, Pune, India.

Int Angiol 2022 May 18. Epub 2022 May 18.

Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de S. João, Porto, Portugal.

Introduction: Venous Thromboembolism (VTE) is a possible complication after varicose vein surgery, reported after both open and endovascular interventions. Nonetheless, there are no internationally accepted recommendations regarding postoperative VTE prevention strategies, with some authors advocating for its use, while others recommend against it. This study aims to systematically review current evidence on the efficacy and safety of chemothromboprophylactic strategies after varicose vein surgery. Read More

Eur Heart J 2022 May 18. Epub 2022 May 18.

Sorbonne Université, ACTION Group, INSERM UMRS 1166, Hôpital Pitié-Salpêtrière (AP-HP), Institut de Cardiologie, Paris 75013, France.

Aims: The respective roles of oral anticoagulation or antiplatelet therapy following transcatheter aortic valve implantation (TAVI) remain debated. ATLANTIS is an international, randomized, open-label, superiority trial comparing apixaban to the standard of care.

Methods And Results: After successful TAVI, 1500 patients were randomized (1:1) to receive apixaban 5 mg (2. Read More

Pol J Radiol 2022 5;87:e207-e214. Epub 2022 Apr 5.

Department of Cardiology, Pamukkale University, Denizli, Turkey.

Purpose: To evaluate the prevalence and significance of incidental non-cardiac findings (NCFs) on cardiac magnetic resonance imaging (MRI). We also aimed to assess the unreported rate and clinical significance of NCFs in official radiological reports.

Material And Methods: Consecutive cardiac MRI examinations of 400 patients were retrospectively analysed and MR images reviewed by 2 observers blinded to official radiology reports. Read More

J Cardiol Cases 2022 May 20;25(5):289-291. Epub 2021 Dec 20.

Section of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, Calgary, Alberta, Canada.

Primary tumors of the heart are rare where nearly half of the benign cardiac masses are myxomas. Clinical features of myxoma are determined by their location, size, and mobility. Most patients present with one or more of the triad of embolism, intracardiac obstruction, and constitutional symptoms. Read More

Med Clin (Barc) 2022 May 14. Epub 2022 May 14.

Servicio de Cardiología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.

Support Care Cancer 2022 May 17. Epub 2022 May 17.

Medical Oncology Department, Hospital Clinic Barcelona, Barcelona, Spain.

Pulmonary embolism (PE) is a leading cause of morbidity and mortality in patients with cancer. The clinical presentation and outcomes of PE range from an acute life-threatening condition requiring intensive care to a mild symptomatic condition associated with favorable outcomes and potentially candidate for early hospital discharge. The wide clinical spectrum of PE has led to the development of risk stratification models aimed at the triage of patients in emergency care departments and optimizing the utilization of health care resources. Read More

G Ital Cardiol (Rome) 2022 05;23(5)

Malattie dell'apparato Cardiovascolare, Università degli studi di Ferrara.

J Cardiothorac Vasc Anesth 2022 Mar 31. Epub 2022 Mar 31.

Columbia University College of Physicians and Surgeons, New York, NY, United States; Center for Acute Respiratory Failure, New York Presbyterian Hospital, New York, NY, United States.

Extracorporeal membrane oxygenation (ECMO) is an established part of the treatment algorithm for coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. An intense inflammatory response may cause an imbalance in the coagulation cascade making both thrombosis and bleeding common and notable features of the clinical management of these patients. Large observational and retrospective studies provide a better understanding of the pathophysiology and management of bleeding and thrombosis in COVID-19 patients requiring ECMO. Read More

CMAJ 2022 May;194(19):E689-E690

Département de médecine interne, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Inde

J Thorac Imaging 2022 May 9. Epub 2022 May 9.

Department of Radiology, University of Washington, Seattle, WA.

Purpose: Coronary artery calcium (CAC) is a frequent incidental finding on computed tomography pulmonary angiogram (CTPA) in the evaluation of pulmonary embolism (PE) in the emergency department (ED); however, its prognostic value is unclear. In this study, we interrogate the prognostic value of CAC identified on CTPA in predicting adverse outcomes in the evaluation of PE in the ED.

Materials And Methods: In this retrospective cohort study, we identified 610 patients presenting to the ED in 2013 and evaluated with CTPA for suspected PE. Read More

Blood 2022 May 16. Epub 2022 May 16.

NHLBI / NIH, Bethesda, Maryland, United States.

Polymerization of deoxygenated hemoglobin S (HbS) underlies the pathophysiology of sickle cell disease (SCD). In activating red blood cell pyruvate kinase and glycolysis, mitapivat (AG-348) increases adenosine triphosphate (ATP) levels and decreases the 2,3-diphosphoglycerate (2,3-DPG) concentration, an upstream precursor in glycolysis. Both changes have therapeutic potential for patients with SCD. Read More

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):369-374

King Fahad Medical City, Riyadh, Saudi Arabia.

The COVID-19 infection has spread rampantly, attaining pandemic status within three months of its first appearance. It has been classically associated with respiratory signs and symptoms. However, unusual presentations have also been reported in multiple literatures. Read More