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    The importance of post thrombotic syndrome as an outcome after deep venous thrombosis: A survey of Canadian thrombosis clinicians.
    Thromb Res 2017 Sep 15;159:13-15. Epub 2017 Sep 15.
    Internal Medicine, Research in Hematology Department, Hospital Privado de la Comunidad, Mar del Plata, Buenos Aires, Argentina.
    Objectives: The development of post thrombotic syndrome (PTS) is a major source of morbidity and reduced quality of life. We sought to determine the value assigned by clinicians to post thrombotic syndrome and whether clinicians believe that any post thrombotic syndrome or severe post thrombotic syndrome are important outcomes to assess after deep vein thrombosis (DVT) as compared to other outcomes.

    Design: The design of the study was a self-responded electronic survey. Read More

    [Fibrates and risk of venous thromboembolism: Case/no-case study in French pharmacovigilance database].
    Therapie 2017 Aug 1. Epub 2017 Aug 1.
    Service de pharmacologie clinique, centre régional de pharmacovigilance de Basse Normandie, CHU Côte-de-Nacre, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France.
    Introduction: Several studies have investigated the occurrence of venous thromboembolic events (phlebitis and pulmonary embolism) [VTE] and fibrates. Fibrates could be associated with VTE although published data are contradictory. The objective of this study is to confirm the link between VTE and fibrates. Read More

    Continuous Aspiration Mechanical Thrombectomy for the Management of Submassive Pulmonary Embolism: A Single-Center Experience.
    J Vasc Interv Radiol 2017 Oct;28(10):1348-1352
    Miami Cardiac & Vascular Institute, Baptist Hospital of Miami, 8900 North Kendall Drive, Miami, FL 33176.
    The Indigo Mechanical Thrombectomy System (Penumbra, Inc, Alameda, California) was used to treat 6 patients with submassive pulmonary embolism (PE) and a contraindication to thrombolysis. Systolic pulmonary artery pressure (58.2 mm Hg vs 43. Read More

    No added value of the age-adjusted D-dimer cut-off to the YEARS algorithm in patients with suspected pulmonary embolism.
    J Thromb Haemost 2017 Sep 22. Epub 2017 Sep 22.
    Department of Medicine, Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The YEARS algorithm was designed to simplify the diagnostic work-up of pulmonary embolism (PE) and to reduce the number of necessary computed tomography pulmonary angiography (CTPA) scans. An alternative strategy to reduce the number of CTPAs is the age-adjusted D-dimer cut-off (ADJUST) in patients aged 50 years or older. We aimed to investigate whether a combination of both diagnostic strategies might save additional CTPAs. Read More

    Lung function, functional capacity, and respiratory symptoms at discharge from hospital in patients with acute pulmonary embolism: A cross-sectional study.
    Physiother Theory Pract 2017 Sep 22:1-8. Epub 2017 Sep 22.
    c Department of Health and Rehabilitation, Unit of Physiotherapy , Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
    Background: Acute pulmonary embolism (PE) is a cardiovascular disease with symptoms including respiratory associated chest pain (RACP) and dyspnea. No previous studies exist focusing on lung function, functional capacity, and respiratory symptoms at discharge after PE.

    Objectives: The aim was to examine and describe lung function, functional capacity, and respiratory symptoms at discharge in patients with PE and compare to reference values. Read More

    Venous thromboembolism due to hyperhomocysteinaemia and tuberculosis.
    Natl Med J India 2017 May-Jun;30(3):139-141
    Department of Pulmonary Medicine, T.N. Medical College and B.Y.L. Nair Hospital, Mumbai 400008, Maharashtra, India.
    An 18-year-old male presented to our hospital with complaints of episodic abdominal pain, dry cough and right pleuritic chest pain. He was diagnosed as a case of right tuberculous pleural effusion on the basis of the pleural fluid Genexpert report of Mycobacterium tuberculosis detected sensitive to rifampicin and was started on antituberculous therapy. Forty-five days later, he presented with acute onset breathlessness, swelling of the right leg, streaky haemoptysis and a fresh left-sided pleural effusion. Read More

    [A case of large pulmonary embolism in trunk and branches with main manifestation of syncope, vomiting and shock].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Sep;29(9):844-847
    Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China (Wen RB, He LF); Department of Emergency Medical, Affiliated Changzheng Hospital of Second Military Medical University, Shanghai 200003, China (Zhang S, Zhou QX, Qu JL, Guan J, Lin ZF); Department of Ultrasonic Diagnosis, Affiliated Changzheng Hospital of Second Military Medical University, Shanghai 200003, China (Ji XF); Department of Imaging Diagnosis, Affiliated Changzheng Hospital of Second Military Medical University, Shanghai 200003, China (Wang P). Corresponding author: Lin Zhaofen, Email:
    Objective: Pulmonary embolism (PE) refers to the endogenous or exogenous emboli blocking pulmonary trunk or branches, causing clinical and pathophysiological syndrome of pulmonary circulation disorder, the incidence rate is high. Sometimes PE patients were lack of specific symptoms and signs, or without any symptoms, which often result in misdiagnosis, un-timely diagnosis, and the delay of treatment. A PE case with syncope, vomiting and shock, which was proved to be pulmonary artery trunk and branch wide embolism later, was presented so as to improve the understanding of the disease. Read More

    Favorable results from a prospective evaluation of 200 patients with large hiatal hernias undergoing LINX magnetic sphincter augmentation.
    Surg Endosc 2017 Sep 21. Epub 2017 Sep 21.
    SurgOne Foregut Institute, 401 W Hampden Place Suite 230, Englewood, CO, 80110, USA.
    Introduction: Magnetic sphincter augmentation (MSA) of the lower esophageal sphincter restores the antireflux barrier in patients with hiatal hernias ≤3 cm. We performed a prospective study in patients undergoing MSA with the LINX device during repair of paraesophageal and hernias over 3 cm axial component.

    Methods And Procedures: Multicenter, prospective study of consecutive patients treated with MSA at the time of repair of hiatal hernias >3 cm. Read More

    The risk of venous thromboembolism associated with peripherally inserted central catheters in ambulant cancer patients.
    Thromb J 2017 19;15:25. Epub 2017 Sep 19.
    Queen's Centre for Oncology and Haematology, Castle Hill Hospital, Hull and East Yorkshire Hospitals Trust, Hull, UK.
    Background: Deep vein thrombosis (DVT) is a common complication of peripherally inserted central catheters (PICCs). PICCs are increasingly utilised in the management of cancer patients, a group which carries both additional risks for vascular thromboembolism as well as for complex morbidity. We analysed a cohort of cancer patients subjected to PICC insertion in a single cancer centre for the incidence of all-type vascular thromboembolism (VTE) and investigated relative risk factors. Read More

    Diagnosis of venous thromboembolism in pregnancy.
    Thromb Res 2017 Sep 5. Epub 2017 Sep 5.
    BC Women's Hospital and Health Centre, University of British Columbia, 4500 Oak Street, Vancouver, British Columbia V6H 3N1, Canada. Electronic address:
    The diagnosis of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy still relies on objective imaging. Ancillary testing such as clinical prediction rules and D-dimer testing may have a role in excluding both DVT and PE in these pregnant patients even as we await results from prospective management studies. The anatomical distribution of DVT in pregnancy differs from those in non-pregnant patient with a greater propensity for proximal iliac vein thrombosis. Read More

    Inferior Vena Cava Filters to Prevent Pulmonary Embolism: Systematic Review and Meta-Analysis.
    J Am Coll Cardiol 2017 Sep;70(13):1587-1597
    Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut.
    Background: Inferior vena cava (IVC) filters are widely used for prevention of pulmonary embolism (PE). However, uncertainty persists about their efficacy and safety.

    Objectives: The authors conducted a systematic review and meta-analysis of the published reports on the efficacy and safety of IVC filters. Read More

    Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer: Rationale and Design of the CASSINI Trial. Rationale and Design of the CASSINI Trial.
    Thromb Haemost 2017 Sep 21;117(11). Epub 2017 Sep 21.
    Alok A. Khorana, MD, FACP, Cleveland Clinic, 9500 Euclid Avenue/R35, Cleveland, OH 44195, United States
    Venous thromboembolism (VTE) is a frequent complication of cancer associated with morbidity, mortality, increased hospitalizations and higher health care costs. Cancer patients at increased risk for VTE can be identified using a validated risk assessment score, and the incidence of VTE can be reduced in high-risk settings using anticoagulation. Rivaroxaban is a potent, oral, direct, factor Xa inhibitor approved for the prevention and treatment of thromboembolic events, including VTE. Read More

    [Venous thromboembolism (VTE) - current diagnosis and therapy, with special attention towards oncologic patients].
    Magy Onkol 2017 Sep 17;61(3):267-274. Epub 2017 Jul 17.
    Ritka Betegségek Szakértõi Központ és Belgyógyászati Intézet, Debreceni Egyetem Klinikai Központ, Ritka Betegségek Részleg, Debrecen, Hungary.
    Deep vein thrombosis (DVT), pulmonary embolism (PE), or with the common name venous thromboembolism (VTE) are frequent manifestations of pathologic hemostasis in malignancies, thereby contributing to the large number of patients despite recent developments in thrombosis prevention. In the present paper up-to-date practice of diagnosis and therapy will be discussed partly based on the author's previous publications on epidemiology and prophylaxis of VTE in oncological patients. Read More

    Military use of tranexamic acid in combat trauma: Does it matter?
    J Trauma Acute Care Surg 2017 Oct;83(4):579-588
    United States Army Institute of Surgical Research (J.T.H., A.P.C., K.R.G.), Battlefield Health and Trauma Center for Human Integrative Physiology (J.T.H.), Department of Defense Joint Trauma System (Z.T.S.), Joint Base San Antonio-Fort Sam Houston, Texas; Bureau of Medicine and Surgery (Z.T.S.), US Navy, Falls Church, Virginia; Department of Surgery (J.A.B.), Uniformed Services University of the Health Sciences (J.A.B.); and Walter Reed National Military Medical Center (J.A.B.), Bethesda, Maryland.
    Background: Tranexamic acid (TXA) has been previously reported to have a mortality benefit in civilian and combat-related trauma, and was thus added to the Joint Theater Trauma System Damage Control Resuscitation Clinical Practice Guideline. As part of ongoing system-wide performance improvement, the use of TXA has been closely monitored. The goal was to evaluate the efficacy and safety of TXA use in military casualties and provide additional guidance for continued use. Read More

    Venous Thromboembolism in Gynecological Malignancy.
    Int J Gynecol Cancer 2017 Sep 19. Epub 2017 Sep 19.
    Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, United Kingdom.
    Objective: Venous thromboembolism (VTE) is a recognized complication of gynecological malignancy and represents a leading cause of morbidity and mortality in these patients. The review aimed to discuss the incidence, risk factors, and clinical presentation of VTE before examining the literature on the diagnosis, prevention, and management in the context of uterine, cervical, ovarian, and vulval cancers.

    Methods/materials: A literature search was performed using Ovid Medline and Embase with the following words: "gynecological malignancy," "pelvic tumor," "venous thromboembolism," "deep vein thrombosis" and "pulmonary embolism. Read More

    Venous thromboembolism in obese pregnant women: approach to diagnosis and management.
    Ginekol Pol 2017 ;88(8):453-459
    Department of Obstetrics & Gynecology, Division of Maternal Fetal Medicine Mount Sinai Hospital,, 600 University Ave, ON M5G 1X5, Toronto, Canada.
    Venous thromboembolism (VTE) remains among the leading causes of maternal mortality in the developed world, presenting variably as deep vein thrombosis (DVT), pulmonary embolism (PE) or cerebral vein thrombosis (CVT), among others. Obesity in particular has been recognized as the principal contributing factor to the risk of VTE in pregnancy and with the global increase in the rates of obesity affecting reproductive age women, heightened awareness of the risk and consequences of VTE in this population are vital. Thus, prophylaxis, diagnosis and treatment of VTE in the obese gravida are discussed. Read More

    Frequency of venous thromboembolism events during acute inpatient rehabilitation in a comprehensive cancer centre.
    J Rehabil Med 2017 Sep 20. Epub 2017 Sep 20.
    Department of Palliative Rehabilitation and Integrative Medicine , University of Texas MD Anderson Cancer Center, 77030 Houston, USA.
    Objective: To determine the frequency of venous thromboembolism, possible predictors, and the association between venous thromboembolism and Functional Independence Measure (FIM) scores and length of stay among cancer patients admitted to the inpatient rehabilitation unit at a cancer centre.

    Design: Retrospective analysis of patients admitted to acute inpatient rehabilitation from September 2011 to June 2013. Subject/patients: Cancer patients in the acute inpatient rehabilitation unit within a tertiary cancer centre. Read More

    Edoxaban is effective in reducing the incidence of asymptomatic phlebographic events following closed-wedge high tibial osteotomy.
    Orthop Traumatol Surg Res 2017 Sep 16. Epub 2017 Sep 16.
    Department of Orthopaedic Surgery, Yokohama City University School of Medicine.
    Introduction: The purpose of this study was twofold:1) to investigate whether edoxaban significantly decreases the rate of venous thromboembolism (VTE) following closed-wedge high tibial osteotomy (CWHTO), in terms of phlebographic event, and 2) to determine whether edoxaban is safe or increases the rate of hemorrhagic complications.We hypothesized that edoxaban would decrease the incidence of VTE and would not increase the rate of hemorrhagic complications.

    Materials And Methods: We randomly enrolled 60 patients undergoing CWHTO. Read More


    Factors Associated with Pulmonary Embolism Recurrence and the Benefits of Long-term Anticoagulant Therapy.
    Cardiovasc Hematol Disord Drug Targets 2017 Sep 18. Epub 2017 Sep 18.
    Complejo Hospitalario de Navarra - Medicina Interna. Sección A Pamplona, Navarra. Spain.
    Background: Venous thromboemboli tend to recur. However, the causative factors underlying pulmonary embolism recurrence are not well defined.

    Aims: To explore the factors associated with pulmonary embolism recurrence. Read More

    Pleuritic Chest Pain: Sorting Through the Differential Diagnosis.
    Am Fam Physician 2017 Sep;96(5):306-312
    Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
    Pleuritic chest pain is characterized by sudden and intense sharp, stabbing, or burning pain in the chest when inhaling and exhaling. Pulmonary embolism is the most common serious cause, found in 5% to 21% of patients who present to an emergency department with pleuritic chest pain. A validated clinical decision rule for pulmonary embolism should be employed to guide the use of additional tests such as d-dimer assays, ventilation-perfusion scans, or computed tomography angiography. Read More

    A Case of Tracheobronchomalacia Mimicking Acute Pulmonary Embolism.
    Am J Case Rep 2017 Sep 19;18:1005-1008. Epub 2017 Sep 19.
    Department of Anesthesiology and Perioperative Medicine, Pennsylvania State College of Medicine/ Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
    BACKGROUND Pulmonary embolism is a common acute postoperative complication and is associated with 100,000 deaths per year in the USA. Tracheobronchomalacia is an uncommon condition, which presents with similar symptoms to pulmonary embolism, including hypoxemia, tachycardia, and shortness of breath. We describe a case of a patient who presented with postoperative pulmonary symptoms that were initially thought to be due to pulmonary embolism. Read More

    Treatment of a mobile intracardiac thrombus using ultra-slow low-dose tissue plasminogen activator in combination with heparin.
    J Clin Pharm Ther 2017 Sep 17. Epub 2017 Sep 17.
    Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
    What Is Known And Objective: Free-floating thrombi in the right heart occur in a subset of patients with pulmonary embolism with high rates of mortality if untreated. Treatment of choice is controversial and likely patient specific as studies have failed to consistently show a significant difference in mortality between options.

    Case Summary: We present a case of a 45-year-old female with a mobile right heart thrombus treated with ultra-slow, low-dose t-PA infusion in combination with heparin. Read More

    A Pulmonary Embolism Response Team's initial 20 month experience treating 87 patients with submassive and massive pulmonary embolism.
    Vasc Med 2017 Sep 1:1358863X17730430. Epub 2017 Sep 1.
    6 Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, NY, USA.
    Pulmonary Embolism Response Teams (PERTs) have emerged to provide rapid multidisciplinary assessment and treatment of PE patients. However, descriptive institutional experience and preliminary outcomes data from such teams are sparse. PERT activations were identified through a retrospective review. Read More

    Reversible Causes in Cardiovascular Collapse at the Emergency Department Using Ultrasonography (REVIVE-US).
    Ann Acad Med Singapore 2017 Aug;46(8):310-316
    Emergency Medicine Department, National University Hospital, Singapore.
    Introduction: Ultrasonographic evaluation of patients in cardiac arrest is currently not protocolised in the advanced cardiac life support (ACLS) algorithm. Potentially reversible causes may be identified using bedside ultrasonography that is ubiquitous in most emergency departments (EDs). This study aimed to evaluate the incidence of sonographically detectable reversible causes of cardiac arrest by incorporating an ultrasonography protocol into the ACLS algorithm. Read More

    Modern diagnosis of chronic thromboembolic pulmonary hypertension.
    Thromb Res 2017 Sep 9. Epub 2017 Sep 9.
    Division of Pneumology, University Hospitals of Geneva, Geneva, Switzerland; Pulmonary Hypertension Program, University Hospitals of Geneva, Geneva, Switzerland; Geneva University, Faculty of Medicine, Switzerland. Electronic address:
    Chronic thromboembolic pulmonary hypertension (CTEPH) should be suspected in patients presenting persistent dyspnea three months after a pulmonary embolism or in patients presenting with acute pulmonary embolism and suggestive images on the CT-scan. For these patients, a specific diagnostic work-up should be performed. First step consists of the ventilation/perfusion (V/Q) scan which is a good screening test due to its high sensitivity and high negative predictive value. Read More

    [Circular tracheal resection for cicatrical stenosis and functioning tracheostomy].
    Khirurgiia (Mosk) 2017 (9):23-32
    Sechenov First Moscow State Medical University, Moscow, Russia, Burdenko Clinic of Faculty Surgery, Moscow, Russia.
    Aim: To analyze the results of tracheal resection for cicatricial stenosis depending on the presence of tracheostomy.

    Material And Methods: 1128 patients with tracheal cicatricial stenosis were treated for the period 1963-2015. The first group consisted of 297 patients for the period 1963-2000, the second group - 831 patients for the period 2001-2015. Read More

    Emergency Neurological Life Support: Resuscitation Following Cardiac Arrest.
    Neurocrit Care 2017 Sep 14. Epub 2017 Sep 14.
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Cardiac arrest is the most common cause of death in North America. An organized bundle of neurocritical care interventions can improve chances of survival and neurological recovery in patients who are successfully resuscitated from cardiac arrest. Therefore, resuscitation following cardiac arrest was chosen as an Emergency Neurological Life Support protocol. Read More

    Challenges of Anticoagulation Therapy in Pregnancy.
    Curr Treat Options Cardiovasc Med 2017 Sep 14;19(10):76. Epub 2017 Sep 14.
    Massachusetts General Hospital, 55 Fruit Street, POB 224, Boston, MA, 02114, USA.
    Opinion Statement: Thrombotic complications in pregnancy represent a major cause of morbidity and mortality. Pregnancy is a primary hypercoagulable state due to enhanced production of clotting factors, a decrease in protein S activity, and inhibition of fibrinolysis. These physiologic changes will yield a collective rate of venous thromboembolism (VTE) of about 1-2 in 1000 pregnancies for the general obstetric population, which represents a five- to tenfold increased risk in pregnancy compared to age-matched non-pregnant peers. Read More

    Eosinophilic biomarkers for detection of acute exacerbation of chronic obstructive pulmonary disease with or without pulmonary embolism.
    Exp Ther Med 2017 Oct 2;14(4):3198-3206. Epub 2017 Aug 2.
    Department of Respiratory Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, P.R. China.
    Eosinophilia has been implicated in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the role of eosinophil activation in the development of AECOPD remains unclear. In the present study, the reliability of plasma levels of eosinophil activation markers, including eosinophil cationic protein (ECP), major basic protein (MBP), eosinophil-derived neurotoxin (EDN) and eosinophil peroxidase (EPX), were measured and used as diagnostic biomarkers of AECOPD with or without pulmonary embolism (PE). Read More

    Heart-type fatty acid-binding protein in cardiovascular disease: A systemic review.
    Clin Chim Acta 2017 Sep 11. Epub 2017 Sep 11.
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
    Fatty acid-binding proteins, whose clinical applications have been studied, are a family of proteins that reflect tissue injury. Heart-type fatty acid-binding protein (H-FABP) is a marker of ongoing myocardial damage and useful for early diagnosis of acute myocardial infarction (AMI). In the past decade, compared to other cardiac enzymes, H-FABP has shown more promise as an early detection marker for AMI. Read More

    Pulmonary embolism severity assessment and prognostication.
    Thromb Res 2017 Sep 8. Epub 2017 Sep 8.
    Respiratory Department, Ramón y Cajal Hospital, IRYCIS, Alcala de Henares University, Madrid, Spain. Electronic address:
    For patients who have acute symptomatic pulmonary embolism (PE), risk of short-term death and adverse outcomes should drive the initial treatment decisions. Practice guidelines recommend that patients who have a high-risk of PE-related death and adverse outcomes, determined by the presence of haemodynamic instability (i.e. Read More

    [Percutaneous catheterization for extracorporeal membrane oxygenation: a retrospective case series].
    Zhonghua Jie He He Hu Xi Za Zhi 2017 Sep;49(9):678-682
    Beijing Institute of Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
    Objective: To review the experience of percutaneous catheterization for extracorporeal membrane oxygenation (ECMO) by respiratory intensivists at a single institution. Methods: A retrospective review of 87 patients undergoing percutaneous catheterization for ECMO in Department of Respiratory and Critical Care Medicine of Beijing Chaoyang Hospital from November 2009 to January 2017. Subject demographics, type of support, cannulation configuration, types of cannulas, use of imaging modalities, and complications were recorded and summarized. Read More

    Retrospective cause analysis of troponin I elevation in non-CAD patients: Special emphasis on sepsis.
    Medicine (Baltimore) 2017 Sep;96(37):e8027
    aDepartment of Internal Medicine, The Wright Center for Graduate Medical Education (WCGME), Scranton bHematology & Oncology Associates of Northeast Pennsylvania cDepartment of Epidemiology, Harvard T.H. Chan School of Public Health dCommonwealth Health Physician Network Great Valley Cardiology eDepartment of Family Medicine, WCGME fDepartment of Science, Marywood University, Scranton, PA gFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
    Background: Troponin I is one of the most commonly tested biochemical markers in the emergency room (ER) and in the hospital setting. Besides coronary artery disease (CAD), demand ischemia with underlying tachycardia, anemia, hypertensive emergency, congestive heart failure, kidney disease, sepsis, and pulmonary embolism have also been reported to cause troponin I elevations. Few reports have excluded patients with CAD, and no study has summarized the proportion of these factors relative to an increased troponin I level. Read More

    Predictive value of insufficient contrast medium filling in pulmonary veins in patients with acute pulmonary embolism.
    Medicine (Baltimore) 2017 Sep;96(37):e7926
    Radiological Department, Tianjin Chest Hospital, Tianjin, P.R. China.
    This study is to investigate the predictive value of insufficient contrast medium filling (ICMF) in patients with acute pulmonary embolism (PE).A total of 108 PE patients were enrolled and divided into group A and group B according to the presence of ICMF. PE index and ventricul araxial lengths were measured. Read More

    VV-ECMO-Assisted High-Risk Endobronchial Stenting as Rescue for Asphyxiating Mediastinal Mass.
    J Bronchology Interv Pulmonol 2017 Sep 12. Epub 2017 Sep 12.
    Departments of *Internal Medicine ‡Cardiothoracic Surgery †Division of Pulmonary Medicine, Mayo Clinic, Phoenix, AZ.
    The use of venovenous extracorporeal membrane oxygenation (VV-ECMO) has traditionally been limited to a narrow set of clinical circumstances, such as acute hypoxic respiratory failure, submassive pulmonary embolism, and cardiopulmonary collapse. Within the pediatric population, there have been cases of VV-ECMO in the context of extrinsic airway compression by a mediastinal mass, typically in the setting of either a lymphoma or germ cell tumors. However, the use of VV-ECMO for adults with extrinsic airway compression is comparatively limited. Read More

    [Pulmonary embolism at the University Hospital Campus of Lome (Togo): a retrospective study about 51 cases].
    Pan Afr Med J 2017 18;27:129. Epub 2017 Jun 18.
    Service de Cardiologie du CHU Campus, Lomé, Togo.
    Introduction: This study provides an analysis of the evolutionary, clinical and epidemiological aspects of pulmonary embolism at the University Hospital Campus of Lome.

    Methods: We conducted a retrospective, analytic and descriptive study over a period of 39 months (November 1 , 2011- January 31, 2015). All the medical records of patients hospitalized for PE in the Department of Cardiology at the University Hospital Campus were analyzed. Read More

    [Anticoagulant therapy of venous thromboembolic complications: balancing between risks].
    Angiol Sosud Khir 2017 ;23(3):9-17
    Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia; Institute of Surgery named after A.V. Vishnevsky under the RF Ministry of Public Health, Moscow, Russia.
    This article is a review of the literature, related to the problem of recurrence of venous thromboembolic complications and the possibilities of their secondary prevention. The problems of determining the rational duration of anticoagulant therapy on the basis of an individual assessment of its benefit and risk are considered. The information on modern prognostic models allowing quantitative assessment of the probability of hemorrhagic and thrombotic events occurrence is presented (Vienna prediction model, DASH, HAS-BLED, stratification according to ACCP 2016). Read More

    Anticoagulant therapy for acute venous thromboembolism.
    Turk Kardiyol Dern Ars 2017 Sep;45(6):563-571
    Department of Cardiology, İnönü University Faculty of Medicine, Malatya, Turkey.
    Deep vein thrombosis (DVT) and pulmonary embolism (PE) are currently defined as venous thromboembolism (VTE) since they share pathophysiological features and the treatment is similar in many respects. It has been determined that more than 90% of PE cases originate from DVT in the legs. PE, which is difficult to diagnose, has a mortality rate of 12% when untreated. Read More

    Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.
    N Engl J Med 2017 09;377(11):1022-1032
    From the University of California, Los Angeles (UCLA), Ronald Reagan UCLA Medical Center, Los Angeles (J.L.S.); University of Colorado, Denver, and University of Colorado Hospital, Aurora (J.D.C.), and South Denver Cardiology, Swedish Medical Center, Littleton (L.A.M.) - all in Colorado; Tufts University, Tufts Medical Center, Boston (D.E.T.); University of Texas, Memorial Hermann Heart and Vascular Institute, Houston (R.W.S.); Medical College of Wisconsin, Milwaukee (D.S.M.); and University of Washington, Seattle (D.L.T.).
    Background: Whether closure of a patent foramen ovale reduces the risk of recurrence of ischemic stroke in patients who have had a cryptogenic ischemic stroke is unknown.

    Methods: In a multicenter, randomized, open-label trial, with blinded adjudication of end-point events, we randomly assigned patients 18 to 60 years of age who had a patent foramen ovale (PFO) and had had a cryptogenic ischemic stroke to undergo closure of the PFO (PFO closure group) or to receive medical therapy alone (aspirin, warfarin, clopidogrel, or aspirin combined with extended-release dipyridamole; medical-therapy group). The primary efficacy end point was a composite of recurrent nonfatal ischemic stroke, fatal ischemic stroke, or early death after randomization. Read More

    High level of venous thromboembolism in critically ill trauma patients despite early and well-driven thromboprophylaxis protocol.
    Ann Intensive Care 2017 Sep 12;7(1):97. Epub 2017 Sep 12.
    Department of Anaesthesia and Critical Care, AP-HP, Hôpital Bicêtre, Hôpitaux Universitaires Paris Sud, University Paris-Sud, 78 rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
    Background: Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venous thrombosis (DVT) and pulmonary embolism (PE) in critically ill trauma patients, in the setting of a mature and early mechanical and pharmacological thromboprophylaxis protocol.

    Methods: This was a prospective observational study on a cohort of patients from a surgical intensive care unit of a university level 1 trauma centre. Read More

    A case of Legionella pneumophila evaluated with CT and ultrasound.
    J Ultrasound 2017 Sep 24;20(3):243-245. Epub 2017 Feb 24.
    UOSD Ecografia Internistica, Università degli studi G. d'Annunzio Chieti-Pescara, Chieti, Italy.
    A 36-year-old man was admitted to the emergency department of "SS Annunziata" hospital in Chieti complaining of a sharp chest pain arisen some hours before admission. On examination, the patient looked sweaty; his vital signs showed tachycardia and augmented breath rate; sinus tachycardia and normal ventricular repolarization were observed on ECG, and no abnormalities were observed in the echoscan of the hearth. According to the clinical and electrocardiographic findings, and to previous episode of DVT in anamnesis, a thorax CT scan was performed in order to rule out pulmonary embolism. Read More

    Acute Pulmonary Embolism: Retrospective Cohort Study of the Predictive Value of Perfusion Defect Volume Measured With Dual-Energy CT.
    AJR Am J Roentgenol 2017 Sep 12:1-8. Epub 2017 Sep 12.
    1 Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.
    Objective: The purposes of this study were to investigate dual-energy CT findings predictive of clinical outcome and to determine the incremental risk stratification benefit of dual-energy CT findings compared with CT ventricular diameter ratio in patients with acute pulmonary embolism.

    Materials And Methods: A retrospective evaluation was conducted of the cases of 172 patients with acute pulmonary embolism who underwent dual-energy CT. Ventricular diameter ratio and relative perfusion defect volume were measured. Read More

    Cancer-Associated Venous Thromboembolism: A Practical Review Beyond Low-Molecular-Weight Heparins.
    Front Med (Lausanne) 2017 28;4:142. Epub 2017 Aug 28.
    Department of Medicine, McMaster University, Hamilton, ON, Canada.
    Patients with cancer are at significantly higher risk of developing, and dying from, venous thromboembolism (VTE). The CLOT trial demonstrated superiority of low-molecular-weight heparins (LMWH) over warfarin for recurrent VTE and established LMWH as the standard of care for cancer-associated VTE. However, with patients living longer with metastatic cancer, long-term injections are associated with significant cost and injection fatigue. Read More

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