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Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

Background:  Deep vein thrombosis (DVT) can lead to pulmonary embolism (PE), but the mechanisms responsible for this progression are unknown. Previously, we showed that inhibition of thrombin-mediated activation of factor (F) XIII promotes venous thrombus stability in a murine model.

Aim:  In this study, we investigate the consequence of attenuating fibrinolysis, using FXIII, α-antiplasmin (α-AP) or ε-aminocaproic acid (EACA) supplementation, on clot lysis and venous thrombus stability using the same mouse model. Read More

J Surg Res 2019 Apr 17;241:24-30. Epub 2019 Apr 17.

Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: Pulmonary air embolism (PAE)-induced acute lung injury (ALI) can be caused by massive air entry into the lung circulation. PAE can occur during diving, aviation, and some iatrogenic invasive procedures. PAE-induced ALI presents with severe inflammation, hypoxia, and pulmonary hypertension, and it is a serious complication resulting in significant morbidity and mortality. Read More

J Arthroplasty 2019 Apr 1. Epub 2019 Apr 1.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.

Introduction: The influence of patient gender on complications and healthcare utilization remains unexplored. The purpose of the present study was to determine if patient gender significantly affected outcomes following total hip arthroplasty (THA) and total knee arthroplasty (TKA).

Methods: Retrospective cohort study of THA and TKA patients was performed using the Nationwide Inpatient Sample from 2002 to 2011. Read More

Kardiologiia 2019 Apr 18;59(4):92-96. Epub 2019 Apr 18.

Central Clinical Hospital of the Management Affair of President RF, Moscow.

The article presents a clinical case of embolism with bone cement of the right ventricle of the heart and pulmonary artery after percutaneous vertebroplasty in a patient aged 63 years. According to the results of a comprehensive examination using ultrasound and x-ray methods, three foreign bodies were found: in the right ventricle cavity, in the trunk of the pulmonary artery, in the branches of the left pulmonary artery. Considering the stable condition, normal blood oxygen saturation, the lack of influence of formations on intracardiac hemodynamics, it was decided to refrain from surgery, since the risk of intervention exceeded the possible benefit. Read More

PLoS One 2019 18;14(4):e0214649. Epub 2019 Apr 18.

Bayer AG, Berlin, Germany.

Chronic thromboembolic pulmonary hypertension (CTEPH), a rare pulmonary vascular disease, is often misdiagnosed due to nonspecific symptoms. The objective of the study was to develop, refine and validate a case ascertainment algorithm to identify CTEPH patients within the French exhaustive hospital discharge database (PMSI), and to use it to estimate the annual number of hospitalized patients with CTEPH in France in 2015, as a proxy for disease prevalence. As ICD-10 coding specifically for CTEPH was not available at the time of the study, a case ascertainment algorithm was developed in close collaboration with an expert committee, using a two-step process (refinement and validation), based on matched data from PMSI and hospital medical records from 2 centres. Read More

Plast Reconstr Surg 2019 Apr 9. Epub 2019 Apr 9.

Department of Medical Education, Albany Medical College, Albany, NY, USA.

Objective: The deep intramuscular approach during buttock augmentation with fat grafting has been associated with a significantly increased risk for pulmonary fat embolism. This study was designed to provide guidance for the injection into the subcutaneous fat i.e. Read More

Respirol Case Rep 2019 Jul 5;7(5):e00423. Epub 2019 Apr 5.

Department of Radiology Charité Universitätsmedizin Berlin Berlin Germany.

A 21-year old female with diabetes mellitus type 1 presented to our hospital's emergency department having suffered from shortness of breath, mild chest pain, and vomiting following her arrival after a long-distance flight two days earlier. Symptoms had since subsided and physical examination was normal. Blood analysis revealed increased D-dimers and diabetic ketoacidosis. Read More

Clin Case Rep 2019 Apr 3;7(4):740-743. Epub 2019 Mar 3.

Cardiology Department of Shohaday-e-Tajrish Hospital Shahid Beheshti University of Medical Sciences (SBMU) Tehran Iran.

Buprenorphine is used to treat opioid addiction. The spectrum of complications of oral buprenorphine is not well known. We describe two cases and based on a hypothesis is proposed which suggests that the use of oral buprenorphine could be relevant to the increase of thrombotic risk. Read More

Vasc Specialist Int 2019 Mar;35(1):44-47

Department of Vascular Surgery, Nasser Institute for Research and Treatment, Cairo, Egypt.

Popliteal vein aneurysms (PVAs) represent a rare form of venous aneurysms and necessitate prompt management because of their well-established risk of pulmonary embolism (PE). Herein, we report a rare case of PVA without PE, successfully treated with open surgical repair. A 27-year-old man presented to our vascular clinic with chronic pain and swelling in his left lower limb. Read More

Dis Markers 2019 12;2019:2324515. Epub 2019 Mar 12.

Department of Cardiology, Shanghai Tenth People's Hospital, Shanghai 200072, China.

Objective: To investigate the value of the PTX-3 test in evaluating the prognosis of acute pulmonary embolism (APE).

Method: 117 APE patients were selected and divided into two groups according to plasma PTX-3 levels, including the group in which PTX - 3 ≥ 3.0 ng/mL ( = 42) and the group in which PTX - 3 < 3. Read More

F1000Res 2019 14;8:182. Epub 2019 Feb 14.

Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

A 24-year-old male was presented to us with sudden onset of chest pain and dyspnea for the past one hour. There was no history of calf pain, trauma, surgery, prolonged immobilization, long-haul air travel, bleeding diathesis or any other co-morbidity. The patient denied any addiction history. Read More

Med Princ Pract 2019 Apr 17. Epub 2019 Apr 17.

No Abstract. Read More

J Am Acad Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Klippel-Trenaunay Syndrome (KTS) is a vascular malformation overgrowth syndrome characterized by capillary malformation, venous malformation and limb overgrowth, +/- lymphatic malformation. Patients are at an increased risk of hemorrhage and venous thromboembolism (VTE). Consequently, women with this condition often are counseled to avoid pregnancy, but there is minimal data available on the relationship between pregnancy, VTE and bleeding risk. Read More

Radiology 2019 Apr 16:190175. Epub 2019 Apr 16.

From the Department of Radiology, Service de Radiologie A, Groupe Hospitalier Cochin Broca Hotel-Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France.

Hip Int 2019 Apr 16:1120700019841600. Epub 2019 Apr 16.

Department of Orthopaedic Surgery, Stanford Hospital and Clinics, Redwood City, CA, USA.

Introduction: Debate over the ideal agent for venous thromboembolism (VTE) prophylaxis after total hip arthroplasty (THA) has led to changes in prescribing trends of commonly used agents. We investigate variation in utilisation and the differences in VTE incidence and bleeding risk in primary THA after administration of aspirin, warfarin, enoxaparin, or factor Xa inhibitors.

Methods: 8829 patients were age/sex matched from a large database of primary THAs performed between 2007 and 2016. Read More

ANZ J Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Background: Patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) are at risk of venous thromboembolism (VTE). Australian orthopaedic guidelines recommend aspirin and low-molecular-weight heparin (e.g. Read More

QJM 2019 Apr 15. Epub 2019 Apr 15.

Medical Division Manchester Medical Society, Simon Building, Brunswick Street, Manchester.

J Endourol Case Rep 2019 18;5(1):25-27. Epub 2019 Mar 18.

Department of Urology, George Washington University Medical School, Washington, District of Columbia.

Hydrogen peroxide (HO) is a common antiseptic that is available without a prescription in the United States, and it is indicated for minor dermal abrasion; mouth, gum, or dental irritations; and removal of oral secretion. Several other medical uses have also been described, including clot dissolution during endoscopic gastrointestinal evaluation, cleansing of orthopedic surgical sites, and bladder irrigation. However, these uses of HO, as well as high-dose ingestion, have been associated with a wide variety of medical complications, including but not limited to air pulmonary embolism and stroke. Read More

Prostate Cancer Prostatic Dis 2019 Apr 15. Epub 2019 Apr 15.

VA San Diego Health Care System, La Jolla, CA, USA.

Background: There is conflicting evidence regarding the association between androgen deprivation therapy (ADT) for prostate cancer (PC) and the risk of developing stroke and thromboembolic events. Our study evaluated the association between ADT use and development of stroke, transient ischemic attack (TIA), deep vein thrombosis (DVT), and pulmonary embolism (PE) in a homogenous group of men with PC treated with definitive radiation therapy (RT) after controlling for multiple sources of confounding.

Methods: Observational cohort study of patients diagnosed with PC at the US Department of Veterans Affairs between 1 January 2001 and October 31, 2015 and treated with definitive RT. Read More

J Hosp Med 2019 Apr 8;14:E1-E5. Epub 2019 Apr 8.

Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Hospital medicine continues to grow in workforce, clinical scope, and academic inquiry. This article provides a summary of recent high-impact publications for busy clinicians who provide care to hospitalized adults.

Methods: Authors reviewed articles that were published between March 2017 and March 2018 for the Update in Hospital Medicine presentations at the 2018 Society of Hospital Medicine and Society of General Internal Medicine annual meetings. Read More

J Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

K.G. Jebsen - Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.

Background: Limited data exist on the relationship between physical activity and major complications after incident venous thromboembolism (VTE).

Objectives: To investigate whether physical activity was associated with risk of recurrence and mortality in VTE patients recruited from the general population.

Methods: Patients with incident VTE (n=786) derived from the Tromsø Study surveys 4-6 (1994-95, 2001-02 and 2007-08) were included, and data on physical activity was dichotomized according to the activity level reported in the survey preceding the incident VTE (inactive: <1h per week, active: ≥1h per week). Read More

J Am Acad Orthop Surg 2019 Apr 11. Epub 2019 Apr 11.

From the Department of Orthopaedics, Wexner Medical Center at The Ohio State University Columbus, OH.

Introduction: The Center for Medicare Services currently bundles all shoulder arthroplasties, total shoulder arthroplasty and reverse total shoulder arthroplasty, into one Diagnosis-Related Group on which bundled reimbursements are then further characterized. An arthroplasty performed for traumatic indications, such as fractures, may have a different postoperative course of care compared with the one being done for degenerative arthritis/osteoarthritis (OA), despite having the same Current Procedural Terminology (CPT) and Diagnosis-related Group code.

Methods: The 2012 to 2016 American College of Surgeons-National Surgical Quality Improvement Program databases were queried using CPT-23472 to retrieve records of patients undergoing total shoulder arthroplasty/reverse total shoulder arthroplasty for degenerative arthritis/OA or proximal humerus fracture. Read More

Am J Respir Crit Care Med 2019 Apr;199(8):P15-P16

Global Spine J 2019 Apr 31;9(2):138-142. Epub 2018 Jul 31.

University of Utah, Salt Lake City, UT, USA.

Study Design: Retrospective review.

Objective: To determine whether abnormal preoperative testing is associated with postoperative complications in patients undergoing a microdiscectomy.

Methods: Patients undergoing a microdiscectomy between 2006 and 2013 were identified in the National Surgical Quality Improvement Program database based on appropriate current procedural terminology coding. Read More

F1000Res 2019 25;8. Epub 2019 Mar 25.

Pulmonary Vascular Diseases Unit, Royal Papworth Hospital, Cambridge, CB23 3RE.

Acute pulmonary embolism (PE) is a disease frequently encountered in clinical practice. While the management of haemodynamically stable, low risk patients with acute PE is well established, managing intermediate disease often presents a therapeutic dilemma. In this review, we discuss the various therapeutic options available in this patient group. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):455-461

Department of Orthopedics, the Fourth People's Hospital of Zigong, Zigong Sichuan, 643000, P.R.China.

Objective: To evaluate the effectiveness of three-dimensional (3D) printing assisted internal fixation for unstable pelvic fractures.

Methods: The clinical data of 28 patients with unstable pelvic fractures admitted between March 2015 and December 2017 were retrospectively analyzed. The patients were divided into two groups according to different surgical methods. Read More

Turk Kardiyol Dern Ars 2019 Apr;47(3):191-197

Department of Cardiology, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

Objective: Acute pulmonary embolism (APE) is a serious clinical situation and atrial fibrillation (AF) is the most common arrhytmia in clinical practice. The Pulmonary Embolism Severity Index (PESI) is an accepted risk stratification tool used to predict short term mortality in APE. The aim of this study was to evaluate the relationship between the PESI score and new-onset AF in patients with APE. Read More

J Arthroplasty 2019 Mar 13. Epub 2019 Mar 13.

Consultant Orthopaedic Surgeon, Trauma and Orthopaedics, University Hospital of Leicester NHS Trust, Leicester, UK.

Background: Venous thromboembolism is a serious complication after total hip and knee arthroplasty. There is still no consensus regarding the best mode of thromboprophylaxis after lower limb arthroplasty. The aim of this study was to ascertain the efficacy, safety profile, and rate of adverse thromboembolic events of aspirin as extended out-of-hospital pharmacological anticoagulation for elective primary total hip and knee arthroplasty patients and whether these rates were comparable with published data for low-molecular-weight heparin (LMWH). Read More

Ann Vasc Surg 2019 Apr 27;56:17-23. Epub 2018 Oct 27.

Department of Surgery, New York University Langone Medical Center, New York, NY. Electronic address:

Background: Inferior vena cava thrombosis (IVCT), although rare, has a potential for significant morbidity and mortality. IVCT is often a result of IVC filter thrombosis, but it can also occur de novo. Although anticoagulation remains the standard of care, endovascular techniques to restore IVC patency have become key adjunctive therapies in recent years. Read More

Thromb Res 2019 Apr 7;178:59-62. Epub 2019 Apr 7.

Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.

The main objectives of therapeutic trials in venous thromboembolism (VTE) are to prevent recurrent VTE, major bleeding and death. While these outcomes are indeed highly relevant, they are also rare and do not fully capture the overall functional outcome of VTE patients. Importantly, functional limitations after VTE are prevalent after both deep vein thrombosis and pulmonary embolism occurring in up to 50% of patients. Read More

Int J Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK; Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

Background: The rates of readmission for serious cardiovascular events among patients admitted with a diagnosis of non-specific chest pain are unknown.

Methods: A national retrospective cohort study in the United States was undertaken to evaluate the rates, trends and predictors of readmission for serious cardiovascular events (acute coronary syndrome (ACS), pulmonary embolism (PE) and aortic dissection (AD)) after an inpatient episode with a primary diagnosis of non-specific chest pain.

Results: Among 1,172,430 patients with an index diagnosis of non-specific chest pain between 2010 and 2014, 2. Read More

Semin Perinatol 2019 Mar 9. Epub 2019 Mar 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6651 Main Street, Suite F420, Houston, Texas.

A sustained increase in the maternal death rate in the U.S. remains one of the most challenging issues of the twenty-first century. Read More

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Apr 12;54(4):295-300. Epub 2019 Apr 12.

A 46-year-old woman on oral contraceptives developed an intrahepatic hematoma due to a benign hepatic tumor. As an incidental finding, a computed tomography showed a pulmonary embolism. Unfractionated heparin was given in a prophylactic dosing in an attempt to balance the risk of further intrahepatic bleeding with that of thrombosis. Read More

Ir J Med Sci 2019 Apr 11. Epub 2019 Apr 11.

Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James's Hospital, Dublin, Ireland.

Hepatol Commun 2019 Apr 5;3(4):513-524. Epub 2019 Feb 5.

Katharine Dormandy Haemophilia and Thrombosis Centre Royal Free Hospital London United Kingdom.

Patients with liver disease frequently develop coagulopathy, and fresh frozen plasma is traditionally used for correction of coagulopathy to manage and prevent bleeding. Prothrombin complex concentrates (PCCs) offer an attractive alternative because they are more readily available and avoid large-volume transfusion. This retrospective, single-center study reviewed clinical use of PCC in patients with acute/chronic liver disease. Read More

J Orthop 2019 Jul-Aug;16(4):312-319. Epub 2019 Mar 26.

Hurley Medical Center, Department of Internal Medicine, Flint, MI, USA.

Background: Patients who undergo knee or hip arthroplasty are at a significant risk of venous thromboembolism (VTE) development (pulmonary embolism and/or deep-vein thrombosis). Many different thromboprophylactic strategies have been used for the prevention of VTE in these patients with different outcomes. Therefore, our aim was to evaluate the efficacy and safety of aspirin prophylaxis when compared with placebo or anticoagulants in this population of patients. Read More

J Orthop 2019 Jul-Aug;16(4):294-302. Epub 2019 Mar 21.

Hurley Medical Center, Department of Internal Medicine, Flint, MI, USA.

Background: Patients who undergo knee or hip arthroplasty are at a significant risk of venous thromboembolism (VTE) development (pulmonary embolism and/or deep-vein thrombosis). Many different thromboprophylactic strategies have been used for the prevention of VTE in these patients with different outcomes. Therefore, our aim was to evaluate the efficacy and safety of aspirin prophylaxis when compared with placebo or anticoagulants in this population of patients. Read More

Haematologica 2019 Apr 11. Epub 2019 Apr 11.

Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain;

Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). Read More

Heart Lung Circ 2019 Jan 30. Epub 2019 Jan 30.

Department of Cardiology, Concord Hospital, The University of Sydney, Sydney, NSW, Australia. Electronic address:

Background: Clinical features and outcomes of patients with hypoalbuminaemia in acute pulmonary embolism (PE) have never been studied. The present study investigated the incidence and determined the prognostic significance of hypoalbuminaemia in patients with confirmed acute PE.

Methods: From a dedicated tertiary-referral centre database involving 1,426 consecutive patients admitted with confirmed PE (2000-2012), 1,032 patients had serum albumin assessed on admission (day-1). Read More

Ann Am Thorac Soc 2019 Apr 11. Epub 2019 Apr 11.

University of Pennsylvania Perelman School of Medicine, 14640, Medicine , Philadelphia, Pennsylvania, United States.

J Clin Oncol 2019 Apr 11:JCO1801779. Epub 2019 Apr 11.

3 European Institute of Oncology IRCCS, Milan, Italy.

Purpose: Tamoxifen administered for 5 years at 20 mg/d is effective in breast cancer treatment and prevention, but toxicity has limited its broad use. Biomarker trials showed that 5 mg/d is not inferior to 20 mg/d in decreasing breast cancer proliferation. We hypothesized that a lower dose given for a shorter period could be as effective in preventing recurrence from breast intraepithelial neoplasia but have a lower toxicity than the standard dose. Read More

Surg Case Rep 2019 Apr 11;5(1):57. Epub 2019 Apr 11.

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Kawada 8-1, Shinjuku-ku, Tokyo, 162-0054, Japan.

Background: Hepatocellular carcinoma (HCC) with tumor thrombus (TT) in the right atrium is a critical condition. The general consensus is to perform hepatectomy prior to cavo-atrial thrombectomy because of the risk of uncontrollable bleeding during the liver transection after heparinization. However, sudden cardiac arrest due to the ball-valve effect and pulmonary embolism have been reported in cases of TT. Read More

Int J Legal Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, CH-8057, Zurich, Switzerland.

Purpose: Pulmonary fat embolism (PFE) is a relevant diagnosis playing a role as a sign of vitality or a cause of death. Its severity is assessed according to histological grading systems like that of Falzi. The aim of this study was to determine the utility of unenhanced postmortem computed tomography (PMCT) for PFE diagnosis based on the detection of fat layers. Read More

ERJ Open Res 2019 Apr 8;5(2). Epub 2019 Apr 8.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Pulmonary embolism (PE) is common and guidelines recommend outpatient care only for PE patients with low predicted mortality. Outcomes for patients with intermediate-to-high predicted mortality managed as outpatients are unknown. Electronic records were analysed for adults with PE managed on our ambulatory care unit over 2 years. Read More

Afr J Emerg Med 2019 26;9(Suppl):S61-S63. Epub 2018 Jul 26.

Trauma and Trauma Intensive Care Unit, Inkosi Albert Luthuli Central Hospital, 800 Vusi Mzimela Road, Cato Manor, Durban 4091, South Africa.

Introduction: Bullet emboli occur when bullets migrate from an entry point to an abnormal endpoint via blood vessels or bowel. Most result from low-velocity, small calibre civilian gunshots. Although rare, when it does occur, it commonly embolises to the arterial system. Read More

J Tehran Heart Cent 2018 Oct;13(4):186-190

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Iliofemoral deep vein thrombosis (IFDVT) is a potentially devastating condition comprising a quarter of all cases of lower extremity DVT. It can lead to serious consequences such as pulmonary embolism, limb malperfusion, and post-thrombotic syndrome (PTS), which is a chronic sequela of IFDVT. We herewith present 18 IFDVT cases managed with catheter-directed thrombolysis at our hospital. Read More

Ann Card Anaesth 2019 Apr-Jun;22(2):229-232

Department of Cardiology, DMCH, Ludhiana, Punjab, India.

Perioperative complications of prolonged surgery and prone positioning are well known. Changing the position from prone to supine in an anesthetized patient can result in aspiration and airway obstruction. The drop-in oxygen saturation and hemodynamic changes are warning signs and can cause acute cardiac decompensation leading to diagnostic dilemma. Read More

Arq Gastroenterol 2019 Apr 4. Epub 2019 Apr 4.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Gastroenterologia, Hospital das Clínicas, Serviço de Endoscopia Gastrointestinal, São Paulo, SP, Brasil.

Background: One of the most feared complications with the use of cyanoacrylate for treatment of gastric varices is the occurrence of potentially life-threatening systemic embolism. Thus, endoscopists are turning towards new techniques, including endoscopic coiling, as a potentially safer and more effective treatment option. However, no studies have been performed comparing the two techniques. Read More

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619841700

1 Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico.

The sticky platelet syndrome (SPS) is a common cause of both arterial and venous thrombosis, being a dominant autosomal disease with qualitative platelet alterations and familial occurrence. It is characterized by platelet hyperreactivity with increased platelet aggregability in response to low concentrations of platelet agonists: epinephrine, adenosine diphosphate, or both. The clinical manifestations involve venous or arterial thrombosis, recurrent pregnancy loss, and fetal growth retardation. Read More

Monaldi Arch Chest Dis 2019 Mar 20;89(1). Epub 2019 Mar 20.

Aristotle University of Thessaloniki, School of Dentistry.

Both periodontitis and chronic obstructive pulmonary disease (COPD) are among the most common diseases associated with smoking. These conditions frequently present alongside comorbidities including diabetes, coronary heart disease, duodenal ulcer, deep vein thrombosis, pulmonary embolism, osteoporosis and muscle atrophy. Chronic inflammation contributes to the pathology of both periodontitis and COPD, and in patients suffering from both conditions treatment of periodontitis may lead to relief from COPD symptoms as well. Read More