1,224 results match your criteria Pulmonary Edema High-Altitude

Preliminary Evidence-Based Method of Medical Kit Design for Wilderness Expeditions Modeled by a High-Altitude Expedition to Mount Kilimanjaro.

J Emerg Med 2022 May 10. Epub 2022 May 10.

Department of Emergency Medicine, Columbia University Irving Medical Center, New York, New York.

Background: Wilderness expeditions require extensive planning and the correct medical supplies to ensure clinical care is possible in the event of illness or injury. There are gaps in the literature regarding evidence-based methods for medical kit design.

Objectives: This report describes a preliminary method for predicting medical events to determine medical supply requirements for a wilderness expedition. Read More

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Effects of acetazolamide on pulmonary artery pressure and prevention of high altitude pulmonary edema after rapid active ascent to 4,559 m.

J Appl Physiol (1985) 2022 May 5. Epub 2022 May 5.

Pulmonary, Critical Care and Sleep Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, WA, United States.

Acetazolamide prevents acute mountain sickness (AMS) by inhibition of carbonic anhydrase. Since it reduces acute hypoxic pulmonary vasoconstriction (HPV), it may also prevent high-altitude pulmonary edema (HAPE) by lowering pulmonary artery pressure. We tested this hypothesis in a randomized, placebo-controlled, double-blind study. Read More

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High Altitude Pulmonary Edema, High Altitude Cerebral Edema, and Acute Mountain Sickness: an enhanced opinion from the High Andes - La Paz, Bolivia 3,500 m.

Rev Environ Health 2022 May 2. Epub 2022 May 2.

High Altitude Pulmonary and Pathology Institute (HAPPI-IPPA), La Paz, Bolivia.

Traveling to high altitudes for entertainment or work is sometimes associated with acute high altitude pathologies. In the past, scientific literature from the lowlander point of view was primarily based on mountain climbing. Sea level scientists developed all guidelines, but they need modifications for medical care in high altitude cities. Read More

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A novel nonlinear analysis of blood flow dynamics applied to the human lung.

J Appl Physiol (1985) 2022 Apr 14. Epub 2022 Apr 14.

Department of Radiology, University of California San Diego.

The spatial/temporal dynamics of blood flow in the human lung can be measured noninvasively with magnetic resonance imaging (MRI) using arterial spin labeling (ASL). We report a novel data analysis method using nonlinear prediction to identify dynamic interactions between blood flow units (image voxels), potentially providing a probe of underlying vascular control mechanisms. The approach first estimates the linear relationship (predictability) of one voxel time series with another using correlation analysis, and after removing the linear component estimates the nonlinear relationship with a numerical mutual information approach. Read More

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An Unusual Presentation of Pulmonary Edema During an Ice Dive at Altitude.

Mil Med 2022 Apr 8. Epub 2022 Apr 8.

Navy Experimental Dive Unit, Panama City Beach, FL 32407, USA.

Military diving operations occur in a wide range of austere environments, including high-altitude environments and cold weather environments; however, rarely do both conditions combine. Ice diving at altitude combines the physiologic risks of diving, a hypothermic environment, and a high-altitude environment all in one. Careful planning and consideration of the potential injuries and disease processes affiliated with the aforementioned physiologic risks must be considered. Read More

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High-Altitude Pulmonary Edema in Colorado Children: A Cross-Sectional Survey and Retrospective Review.

High Alt Med Biol 2022 Apr 5. Epub 2022 Apr 5.

Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.

Kelly, Timothy D., Maxene Meier, Jason P. Weinman, Dunbar Ivy, John T. Read More

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MIR17HG polymorphisms contribute to high-altitude pulmonary edema susceptibility in the Chinese population.

Sci Rep 2022 03 14;12(1):4346. Epub 2022 Mar 14.

Medical College, Qinghai University, No. 29 Tongren Road, Xining, 810001, Qinghai, China.

High-altitude pulmonary edema (HAPE) is a common acute altitude sickness. This study was designed to investigate the effect of MIR17HG polymorphisms on HAPE risk in the Chinese population. The Agena MassARRAY platform was used to genotype six single-nucleotide polymorphisms (SNPs) in the MIR17HG gene in 244 HAPE patients and 243 non-HAPE controls. Read More

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High Altitude Pulmonary Edema in a Chronic Kidney Disease Patient-Is Peritoneal Dialysis A Risk Factor?

High Alt Med Biol 2022 Mar 28;23(1):96-99. Epub 2022 Feb 28.

Faculty of Medicine, Altiplano University, Puno, Peru.

Vizcarra-Vizcarra, Cristhian A. and Angélica L. Alcos-Mamani. Read More

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Association of variants m.T16172C and m.T16519C in whole mtDNA sequences with high altitude pulmonary edema in Han Chinese lowlanders.

BMC Pulm Med 2022 Feb 25;22(1):72. Epub 2022 Feb 25.

BaYi Children's Hospital, The Seventh Medical Center of PLA General Hospital, No.5 Nan Men Cang, Dong Cheng District, Beijing, 100700, China.

Background: High altitude pulmonary edema (HAPE) is a hypoxia-induced non-cardiogenic pulmonary edema that typically occurred in un-acclimatized lowlanders, which inevitably leads to life-threatening consequences. Apart from multiple factors involved, the genetic factors also play an important role in the pathogenesis of HAPE. So far, researchers have put more energy into the nuclear genome and HAPE, and ignored the relationship between the mitochondrion DNA (mtDNA) variants and HAPE susceptibility. Read More

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February 2022

Oxidative Stress and Diseases Associated with High-Altitude Exposure.

Antioxidants (Basel) 2022 Jan 28;11(2). Epub 2022 Jan 28.

Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.

Several diseases associated with high-altitude exposure affect unacclimated individuals. These diseases include acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and, notably, high-altitude pulmonary hypertension (HAPH), which can eventually lead to right ventricle hypertrophy and heart failure. The development of these pathologies involves different molecules and molecular pathways that might be related to oxidative stress. Read More

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January 2022

High Altitude-Induced Testicular Infarct: a Rare Occupational Hazard.

Indian J Surg 2022 Feb 2:1-3. Epub 2022 Feb 2.

SNM Hospital, Leh, Ladakh 194101 India.

Visit to high altitude with its hypoxic hypobaric environment poses various physiological and biochemical challenges to a human body. If the body is not able to cope up to this changed environment, it leads to various maladies of high altitude like high altitude cerebral oedema, high altitude pulmonary oedema and spontaneous vascular thrombosis. There are reports of high altitude-induced deep venous thrombosis, pulmonary embolism, mesenteric ischemia etc. Read More

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February 2022

Association Between the Polymorphism of Steroid Hormone Metabolism Genes and High-Altitude Pulmonary Edema in the Chinese Han Population.

Int J Gen Med 2022 20;15:787-794. Epub 2022 Jan 20.

Research Center for High Altitude Medical Sciences, School of Medicine, Qinghai University, Qinghai, People's Republic of China.

Purpose: Steroid hormone metabolism plays an essential role in high-altitude pulmonary edema (HAPE) progression. This study aimed to investigate the association between polymorphism in seven steroid hormone metabolism genes (, and ) and HAPE susceptibility among Han Chinese.

Patients And Methods: A total of 41 tagSNPs in the seven genes were genotyped using Sequenom MassARRAY SNP assays from 169 HAPE patients (HAPE-p) and 309 matched Han Chinese individuals resistant to HAPE (HAPE-r). Read More

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January 2022

Medical Conditions and High-Altitude Travel.

N Engl J Med 2022 Jan;386(4):364-373

From the Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle (A.M.L.); and the Altitude Research Center, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora (P.H.H.).

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January 2022

Rescue Emergencies Due to High-Altitude Illnesses Are Rare in Switzerland.

Int J Environ Res Public Health 2022 01 13;19(2). Epub 2022 Jan 13.

Departement fuer Sport, Bewegung und Gesundheit, University of Basel, 4001 Basel, Switzerland.

Background: Despite a potential high risk of acute mountain sickness (AMS) in the Swiss Alps, there is a lack of analyses concerning its relevance over longer periods. In consequence, the aim of this study is to analyze the prevalence of AMS in comparison to other causes of mountain emergencies in recent years in Switzerland.

Material And Methods: Based on the central registry of mountain emergencies of the Swiss Alpine Club (SAC), all cases in the period between 2009 and 2020 were analyzed for AMS including the most severe forms of high-altitude pulmonary edema (HAPE) and high-altitude cerebral edema (HACE). Read More

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January 2022

Implications of a patent foramen ovale for environmental physiology and pathophysiology: do we know the 'hole' story?

J Physiol 2022 04 17;600(7):1541-1553. Epub 2022 Feb 17.

Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA.

The foramen ovale is an essential component of the fetal circulation contributing to oxygenation and carbon dioxide elimination that remains patent under certain circumstances in ∼30% of the healthy adult population, without major negative sequelae in most. Adults with a patent foramen ovale (PFO) have a greater tendency to develop symptoms of acute mountain sickness and high-altitude pulmonary oedema upon ascent to high altitude, and PFO presence is associated with worse cardiopulmonary function in chronic mountain sickness. This increase in altitude illness prevalence may be related to dysregulated cerebral blood flow associated with altered respiratory chemoreflex sensitivity; however, the mechanisms remain to be elucidated. Read More

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High Altitude Pulmonary Edema in a Healthy Pediatric Patient Traveling from Denver to Breckenridge.

Open Access Emerg Med 2022 4;14:1-4. Epub 2022 Jan 4.

Department of Emergency Medicine, Mercy Health St. Elizabeth Boardman Hospital, Boardman, OH, USA.

A healthy 11-year-old boy presented with headache, nausea, and cough to a clinic at 2926 meters of altitude one day after ascending from his home altitude of 1578 meters. The patient had made multiple trips to the same altitude without any symptoms or sequelae throughout his childhood. Physical examination was significant for rales, tachycardia, and pulse oximetry level of 86% on room air. Read More

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January 2022

Respiratory physiology at high altitude and considerations for pediatric patients.

Paediatr Anaesth 2022 Feb;32(2):118-125

Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.

Over 150 million people, including many children, live at high altitude (>2500 m) with the majority residing in Asia and South America. With increases in elevation, the partial pressure of oxygen (pO2) is reduced, resulting in a hypobaric hypoxic environment. Fortunately, humans have evolved adaptive processes which serve to acclimate the body to such conditions. Read More

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February 2022

No effect of patent foramen ovale on acute mountain sickness and pulmonary pressure in normobaric hypoxia.

Exp Physiol 2022 02 10;107(2):122-132. Epub 2022 Jan 10.

Department of Human Physiology, University of Oregon, Eugene, OR, USA.

New Findings: What is the central question to this study? Is there a relationship between a patent foramen ovale and the development of acute mountain sickness and an exaggerated increase in pulmonary pressure in response to 7-10 h of normobaric hypoxia? What is the main finding and its importance? Patent foramen ovale presence did not increase susceptibility to acute mountain sickness or result in an exaggerated increase in pulmonary artery systolic pressure with normobaric hypoxia. This suggests hypobaric hypoxia is integral to the increased susceptibility to acute mountain sickness previously reported in those with patent foramen ovale, and patent foramen ovale presence alone does not contribute to the hypoxic pulmonary pressor response.

Abstract: Acute mountain sickness (AMS) develops following rapid ascent to altitude, but its exact causes remain unknown. Read More

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February 2022

Post-exercise accumulation of interstitial lung water is greater in hypobaric than normobaric hypoxia in adults born prematurely.

Respir Physiol Neurobiol 2022 03 7;297:103828. Epub 2021 Dec 7.

Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.

We aimed to gauge the interstitial lung water accumulation following moderate-intensity exercise under normobaric and hypobaric hypoxic conditions in a group of preterm born but otherwise healthy young adults. Sixteen pre-term-born individuals (age = 21±2yrs.; gestational age = 29±3wk. Read More

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Mitochondrial ribosomal stress in lung diseases.

Am J Physiol Lung Cell Mol Physiol 2022 04 7;322(4):L507-L517. Epub 2021 Dec 7.

Center for Inflammation and Lung Research, Temple University, Philadelphia, Pennsylvania.

Mitochondria are involved in a variety of critical cellular functions, and their impairment drives cell injury. The mitochondrial ribosome (mitoribosome) is responsible for the protein synthesis of mitochondrial DNA-encoded genes. These proteins are involved in oxidative phosphorylation, respiration, and ATP production required in the cell. Read More

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Humans at extreme altitudes.

BJA Educ 2021 Dec 23;21(12):455-461. Epub 2021 Sep 23.

Swiss Sportclinic, Berne, Switzerland.

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December 2021

[Physiological and pathological responses to altitude].

S Doutreleau

Rev Mal Respir 2021 Dec 12;38(10):1013-1024. Epub 2021 Nov 12.

Inserm, UM sports et pathologies, laboratoire HP2, CHU Grenoble-Alpes, université Grenoble Alpes, EXALT - centre d'expertise sur l'altitude, 38000 Grenoble, France. Electronic address:

Hypobaric hypoxia, the hallmark of a high altitude environment, has important physiological effects on both the cardiovascular and respiratory systems in order to maintain a balance between oxygen demand and supply. This dynamic of acclimatization is influenced both by the level of altitude and the speed of progression, but is also very individual with a wide spectrum of responses and sensitivities. This wide range of responses is associated with nonspecific symptoms characterising acute mountain sickness and high-altitude cerebral or pulmonary oedema. Read More

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December 2021

A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss.

Mikkel Bo Brent

Bone 2022 01 13;154:116258. Epub 2021 Nov 13.

Department of Biomedicine, Aarhus University, Aarhus, Denmark. Electronic address:

Mountaineering and exposure to high altitude result in physiological adaptations to the reduced inspiratory oxygen availability. Acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE) are well-described harmful effects of exposure to high altitude. Common to AMS, HAPE, and HACE are distinct clinical signs and symptoms of impaired function. Read More

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January 2022

Pannexin 1-a novel regulator of acute hypoxic pulmonary vasoconstriction.

Cardiovasc Res 2021 Oct 20. Epub 2021 Oct 20.

Institute of Physiology, Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.

Aims: Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated to better aerated lung areas to optimize ventilation-perfusion matching. Yet, the exact sensory and signaling mechanisms by which hypoxia triggers pulmonary vasoconstriction remain incompletely understood. Recently, ATP release via pannexin 1 (Panx1) and subsequent signaling via purinergic P2Y receptors has been identified as regulator of vasoconstriction in systemic arterioles. Read More

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October 2021

Acetazolamide prevents hypoxia-induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle.

Pulm Circ 2021 Oct-Dec;11(4):20458940211049948. Epub 2021 Oct 5.

Division of Pulmonary and Critical Care Medicine, VA Puget Sound Health Care System and University of Washington School of Medicine, St. Louis, MO, USA.

Upon sensing a reduction in local oxygen partial pressure, pulmonary vessels constrict, a phenomenon known as hypoxic pulmonary vasoconstriction. Excessive hypoxic pulmonary vasoconstriction can occur with ascent to high altitude and is a contributing factor to the development of high-altitude pulmonary edema. The carbonic anhydrase inhibitor, acetazolamide, attenuates hypoxic pulmonary vasoconstriction through stimulation of alveolar ventilation via modulation of acid-base homeostasis and by direct effects on pulmonary vascular smooth muscle. Read More

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October 2021

Validity of Peripheral Oxygen Saturation Measurements with the Garmin Fēnix 5X Plus Wearable Device at 4559 m.

Sensors (Basel) 2021 Sep 23;21(19). Epub 2021 Sep 23.

Ludwig Boltzmann Institute for Digital Health and Prevention, 5020 Salzburg, Austria.

Decreased oxygen saturation (SO) at high altitude is associated with potentially life-threatening diseases, e.g., high-altitude pulmonary edema. Read More

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September 2021

Gravitational ischemia in the brain - may be exacerbated by high altitude and reduced partial pressure of oxygen, inducing lung changes mimicking neurogenic pulmonary edema.

Int J Cardiol 2021 11 21;343:105. Epub 2021 Sep 21.

Anatomic Pathology, Lino Rossi Research Center, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20122 Milan, Italy. Electronic address:

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November 2021

Hypobaric hypoxia deteriorates bone mass and strength in mice.

Bone 2022 01 16;154:116203. Epub 2021 Sep 16.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Mountaineers at high altitude are at increased risk of acute mountain sickness as well as high altitude pulmonary and cerebral edema. A densitometric study in mountaineers has suggested that expeditions at high altitude decrease bone mineral density. Surprisingly, the in vivo skeletal effects of hypobaric hypoxia are largely unknown, and have not been studied using advanced contemporary methods to assess bone microstructure. Read More

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January 2022

Retraction notice to "Acute Mountain Sickness, High Altitude Pulmonary Edema, and High Altitude Cerebral Edema: A view from the High Andes" [Respir. Physiol. Neurobiol. (2021) 103628].

Respir Physiol Neurobiol 2021 12 3;294:103778. Epub 2021 Sep 3.

High Altitude Pulmonary and Pathology Institute (HAPPI-IPPA), Av. Copacabana - Prolongación # 55, La Paz, Bolivia.

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December 2021

Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers.

Am J Physiol Cell Physiol 2021 10 1;321(4):C671-C680. Epub 2021 Sep 1.

State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, People's Republic of China.

Hypoxia-induced pulmonary microvascular endothelial cell (PMVEC) monolayers hyperpermeability is vital for vascular leakage, which participates in vascular diseases, such as acute lung injury (ALI) and high-altitude pulmonary edema (HAPE). We previously observed that PMVEC permeability was markedly elevated in hypoxia when cocultured with primary type II alveolar epithelial cells (AECII) in which isthmin1 (ISM1) was highly upregulated. However, whether the upregulation of ISM1 plays a role in hypoxia-induced PMVEC hyperpermeability is unclear. Read More

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October 2021