2,187 results match your criteria Pulmonary Edema Cardiogenic

Bayesian adaptive clinical trial designs for respiratory medicine.

Respirology 2022 Aug 2. Epub 2022 Aug 2.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

The use of Bayesian adaptive designs for clinical trials has increased in recent years, particularly during the COVID-19 pandemic. Bayesian adaptive designs offer a flexible and efficient framework for conducting clinical trials and may provide results that are more useful and natural to interpret for clinicians, compared to traditional approaches. In this review, we provide an introduction to Bayesian adaptive designs and discuss its use in recent clinical trials conducted in respiratory medicine. Read More

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Left ventricular venting in veno-arterial extracorporeal membrane oxygenation: A computer simulation study.

Int J Artif Organs 2022 Jul 28:3913988221115444. Epub 2022 Jul 28.

Advanced Heart Failure and Transplantation Programme, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia.

Introduction: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is the fastest way to restore circulation in refractory cardiogenic shock, however it cannot unload the failing left ventricle. There is a lack of consensus regarding optimal approach to left ventricular venting in V-A ECMO patients with severely depressed or absent left ventricular function.

Methods: A computer model was developed in Matlab Simulink R20016b (MathWorks, Inc. Read More

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Lung Ultrasound Signs to Diagnose and Discriminate Interstitial Syndromes in ICU Patients: A Diagnostic Accuracy Study in Two Cohorts.

Crit Care Med 2022 Jul 22. Epub 2022 Jul 22.

Department of Intensive Care Medicine, Amsterdam University Medical Centers, VUmc, Amsterdam, The Netherlands.

Objectives: To determine the diagnostic accuracy of lung ultrasound signs for both the diagnosis of interstitial syndrome and for the discrimination of noncardiogenic interstitial syndrome (NCIS) from cardiogenic pulmonary edema (CPE) in a mixed ICU population.

Design: A prospective diagnostic accuracy study with derivation and validation cohorts.

Setting: Three academic mixed ICUs in the Netherlands. Read More

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Transfusion-Related Acute Lung Injury Type I Immediately after Open Surgical Repair for Abdominal Aortic Aneurysm.

Ann Vasc Dis 2022 Jun;15(2):146-149

Department of Surgery, Tohoku University Hospital, Sendai, Miyagi, Japan.

A 68-year-old man underwent open surgical repair for an abdominal aortic aneurysm. The intraoperative period had no adverse events until postoperative extubation. His SpO rapidly dropped, and severe acute lung edema developed. Read More

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One-Year Follow up of Noninvasive Respiratory Support in General Wards.

Respir Care 2022 Jul 19. Epub 2022 Jul 19.

Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale, Novara, Italy.

Background: Noninvasive respiratory support (NRS) has been used to treat acute respiratory failure outside the ICU, but existing data have left many knowledge gaps for managing NRS in general wards. The primary objective of this study was to describe indications, duration of treatment, and outcomes of subjects treated with NRS outside the ICU. The secondary objective was to compare outcomes based on age < 80 or ≥ 80 y. Read More

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Parallel-group, randomised, controlled, non-inferiority trial of high-flow nasal cannula versus non-invasive ventilation for emergency patients with acute cardiogenic pulmonary oedema: study protocol.

BMJ Open 2022 07 7;12(7):e052761. Epub 2022 Jul 7.

Department of Emergency Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Introduction: High-flow nasal cannula (HFNC) is an innovative oxygen-delivering technique, which has been shown to effectively decrease the intubation risk in patients with hypoxaemic respiratory failure of various aetiologies compared with conventional oxygen therapy. Also, it has proved to be non-inferior to non-invasive positive pressure ventilation (NIPPV) in patients with hypoxaemic respiratory failure primarily due to pneumonia. Evidence on its benefits compared with NIPPV, which is the standard of care for patients with acute cardiogenic pulmonary oedema (ACPE) with hypoxaemic respiratory distress, is limited. Read More

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An updated HACOR score for predicting the failure of noninvasive ventilation: a multicenter prospective observational study.

Crit Care 2022 07 3;26(1):196. Epub 2022 Jul 3.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwell Health, Lenox Hill Hospital, New York, NY, USA.

Background: Heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) have been used to predict noninvasive ventilation (NIV) failure. However, the HACOR score fails to consider baseline data. Here, we aimed to update the HACOR score to take into account baseline data and test its predictive power for NIV failure primarily after 1-2 h of NIV. Read More

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Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial.

Eur J Heart Fail 2022 Jul 3. Epub 2022 Jul 3.

Emergency Department, Hospital Clinic, Barcelona, Institut d'Investigació Biomèdica August Pi iSunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Aims: Benzodiazepines have been used as safe anxiolytic drugs for decades and some authors have suggested they could be an alternative for morphine for treating acute cardiogenic pulmonary oedema (ACPE). We compared the efficacy and safety of midazolam and morphine in patients with ACPE.

Methods And Results: A randomized, multicentre, open-label, blinded endpoint clinical trial was performed in seven Spanish emergency departments (EDs). Read More

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Happy Heart Syndrome: Frequency, Characteristics, and Outcome of Takotsubo Syndrome Triggered by Positive Life Events.

JACC Heart Fail 2022 Jul 4;10(7):459-466. Epub 2022 May 4.

Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany; German Center for Cardiovascular Research, Partner Site Hamburg-Kiel-Lübeck, Lübeck, Germany.

Background: The association with a preceding stressor is a characteristic feature of takotsubo syndrome (TTS). Negative emotions before TTS are common and led to the popular term "broken heart syndrome." In contrast, pleasant triggers ("happy heart syndrome") are rare and are scarcely investigated. Read More

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Cardiovascular Toxicities with Chimeric Antigen Receptor T-cell Therapy.

Jashan Gill

Curr Cardiol Rev 2022 Jun 23. Epub 2022 Jun 23.

Department of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in treating highly refractory and relapsing hematological malignancies in pediatric and adult patients. However, this promising therapy is limited by severe and potentially life-threatening toxicities. Cytokine release syndrome (CRS) is the most commonly observed of these toxicities. Read More

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Lung Sonography in Critical Care Medicine.

Diagnostics (Basel) 2022 Jun 6;12(6). Epub 2022 Jun 6.

Department of Anaesthesiology and Intensive Care Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.

During the last five decades, lung sonography has developed into a core competency of intensive care medicine. It is a highly accurate bedside tool, with clear diagnostic criteria for most causes of respiratory failure (pneumothorax, pulmonary edema, pneumonia, pulmonary embolism, chronic obstructive pulmonary disease, asthma, and pleural effusion). It helps in distinguishing a hypovolemic from a cardiogenic, obstructive, or distributive shock. Read More

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Prevalence of Reticulocytosis in the Absence of Anemia in Dogs with Cardiogenic Pulmonary Edema Due to Myxomatous Mitral Valve Disease: A Retrospective Study.

Vet Sci 2022 Jun 14;9(6). Epub 2022 Jun 14.

Department of Veterinary Clinical Pathology and Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju 54596, Korea.

Myxomatous mitral valve disease (MMVD) is the most common heart disease in small breed dogs. Dogs with MMVD commonly show clinical signs of dyspnea due to cardiogenic pulmonary edema (CPE). Reticulocytosis in the absence of anemia (RAA) is a hematological finding in hypoxic conditions. Read More

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Mitral valve repair in papillary muscle rupture.

Ann Cardiothorac Surg 2022 May;11(3):281-289

Department of Cardiothoracic Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.

Papillary muscle rupture (PMR) is a significant mechanical complication following myocardial infarction (MI), a condition associated with a high mortality. It results in severe mitral valve regurgitation (MR), often accompanied by cardiogenic shock and pulmonary edema, requiring both emergent medical treatment and surgical intervention. Surgical treatment includes either chordal sparing mitral valve replacement or mitral valve repair, which is associated with a high mortality. Read More

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Risk factors associated with peri-intubation cardiac arrest in the emergency department.

Am J Emerg Med 2022 08 11;58:229-234. Epub 2022 Jun 11.

Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Peri-intubation cardiac arrest is an uncommon, serious complication following endotracheal intubation in the emergency department. Although several risk factors have been previously identified, this study aimed to comprehensively identify risk factors associated with peri-intubation cardiac arrest.

Methods: This retrospective, nested case-control study conducted from January 1, 2016 to December 31, 2020 analyzed variables including demographic characteristics, triage, and pre-intubation vital signs, medications, and laboratory data. Read More

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Atypical pulmonary presentation of hyperinfection in a patient with philadelphia chromosome-positive acute lymphoblastic leukemia: Case report.

IDCases 2022 6;29:e01530. Epub 2022 Jun 6.

University of Missouri, Department of Pathology and Anatomical Sciences, Columbia, MO, USA.

is a soil-transmitted helminth endemic to tropical and subtropical regions and can be acquired due to parasite penetration through the skin. It can remain dormant in the gastrointestinal system for decades after the primary infection. In immunocompromised patients, this parasite can cause autoinfection with progression to hyperinfection syndrome. Read More

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Development and Internal Validation of a Risk Prediction Model for Acute Cardiovascular Morbidity in Preeclampsia.

Can J Cardiol 2022 Jun 13. Epub 2022 Jun 13.

Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, Rhode Island, USA; Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.

Background: Women with preeclampsia are at increased short-term risk of adverse cardiovascular outcomes during pregnancy and the early postpartum period. We aimed to develop and internally validate a risk assessment tool to predict acute cardiovascular morbidity in preeclampsia.

Methods: The study was conducted at an academic obstetrics hospital. Read More

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The role of landiolol in the management of atrial tachyarrhythmias in patients with acute heart failure and cardiogenic shock: case reports and review of literature.

Eur Heart J Suppl 2022 Jun 13;24(Suppl D):D22-D33. Epub 2022 Jun 13.

Emergency Medicine Department, Attikon University Hospital, Rimini 1, Chaidari 12462, Athens, Greece.

Atrial tachyarrhythmias and worsening heart failure frequently coexist and potentially progress to a life threatening condition. Therapeutic approach requires simultaneous management of rapid ventricular response and heart failure symptom relief in order to improve haemodynamic stability and cardiac function. Landiolol is an ultra-short-acting b-adrenergic receptor blocker with high b1 selectivity incorporated in 2020 European Society of Cardiology guidelines for the management of atrial fibrillation. Read More

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Obesity Influences on Patients With Non-valvular Cardiomyopathy in Relation to Early In-Hospital Outcomes and Health System Burden.

Cureus 2022 May 9;14(5):e24859. Epub 2022 May 9.

Cardiology, Banha University, Banha, EGY.

Background Our study aimed to assess the burden of obesity on the health system and outcomes in patients with non-valvular cardiomyopathy. Methods A retrospective analytical cohort, single-center study was conducted at King Abdullah Medical City (KAMC), Makkah, from June 2019 to June 2020, and includes all non-valvular cardiomyopathy (NVCM) patients. The patients were divided into two groups, obese (BMI30) and non-obese (BMI<30). Read More

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[Features of the course of non-ST elevation myocardial infarction in patients with a history of COVID-19].

Kardiologiia 2022 May 31;62(5):18-26. Epub 2022 May 31.

Demikhov Municipal Clinical Hospital, Moscow; Evdokimov Moscow State University of Medicine and Dentistry, Moscow.

Aim      To study the clinical course of non-ST segment elevation myocardial infarction (NSTEMI) in hospitalized patients after COVID-19 and to evaluate the effect of baseline characteristics of patients on the risk of complications.Material and methods  The study included 209 patients with NSTEMI; 104 of them had had COVID-19. The course of myocardial infarction (MI) was analyzed at the hospital stage, including evaluation of the incidence rate of complications (fatal outcome, recurrent MI, life-threatening arrhythmias and conduction disorders, pulmonary edema, cardiogenic shock, ischemic stroke, gastrointestinal bleeding). Read More

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Unique mutations in mitochondrial DNA and associated pathways involved in high altitude pulmonary edema susceptibility in Indian lowlanders.

J Biomol Struct Dyn 2022 Jun 6:1-16. Epub 2022 Jun 6.

Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Timarpur, Delhi, India.

High altitude pulmonary edema (HAPE) is a life threatening non-cardiogenic pulmonary edema that occurs in an otherwise healthy individuals travelling to altitude above 2500 m. Earlier studies have reported association of mutations in nuclear (nDNA) and mitochondrial DNA (mtDNA) with HAPE susceptibility. However, the molecular mechanisms involved in the pathobiology of HAPE have not been fully understood. Read More

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Are we missing reverse TRALI? - A real world experience from a tertiary care oncology centre in India.

Transfus Apher Sci 2022 May 25:103466. Epub 2022 May 25.

Department of Transfusion Medicine, Tata Medical Center, Kolkata, India. Electronic address:

Transfusion related acute lung injury (TRALI) is a rare but potentially fatal pulmonary complication of transfusion that presents as acute hypoxemia and non-cardiogenic pulmonary oedema, developing during or within six hours of transfusion. Majority of the cases reported are due to transfusion of plasma rich blood components containing antibodies to human leukocyte antigen (anti-HLA) or human neutrophil antigen (anti-HNA). Rarely, anti-HLA or anti-HNA in recipients against transfused donor leukocyte antigens, cause TRALI by a reverse mechanism. Read More

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Naloxone-associated pulmonary edema in a 3-year-old with opioid overdose.

J Am Coll Emerg Physicians Open 2022 Jun 23;3(3):e12740. Epub 2022 May 23.

Division of Pediatric Emergency Medicine Department of Emergency Medicine Indiana University School of Medicine Indianapolis Indiana USA.

Background: Annually, close to 5000 children under age 6 years are treated in emergency departments or admitted for care due to opioid exposures. Naloxone is effectively used to treat opioid overdose in both children and adults. Non-cardiogenic pulmonary edema is a rare but serious adverse effect of naloxone administration that has been reported in adults. Read More

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Re-Expansion Pulmonary Edema in Children - A Rare Complication After Pneumothorax Drainage: A Case Report.

Int Med Case Rep J 2022 9;15:239-243. Epub 2022 May 9.

St Paul's Hospital Millennium Medical College, Department of Pediatrics and Child Health, Addis Ababa, Ethiopia.

Background: Re-expansion Pulmonary Edema (RPE) is a non-cardiogenic form of pulmonary edema which occurs following rapid lung expansion after drainage of significant pneumothorax or pleural effusion, and rarely following resection of obstructive mediastinal mass. RPE is a rare but potentially fatal phenomenon with only few case reports in the pediatric literature.

Methods: We are reporting a case of RPE in a 5-year-old girl following drainage of pneumothorax who succumbed to worsening hypoxemia despite therapy with mechanical ventilation and other supportive care. Read More

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Respiratory-Cardiovascular Interactions During Mechanical Ventilation: Physiology and Clinical Implications.

John Kreit

Compr Physiol 2022 04 26;12(3):3425-3448. Epub 2022 Apr 26.

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Positive-pressure inspiration and positive end-expiratory pressure (PEEP) increase pleural, alveolar, lung transmural, and intra-abdominal pressure, which decrease right and left ventricular (RV; LV) preload and LV afterload and increase RV afterload. The magnitude and clinical significance of the resulting changes in ventricular function are determined by the delivered tidal volume, the total level of PEEP, the compliance of the lungs and chest wall, intravascular volume, baseline RV and LV function, and intra-abdominal pressure. In mechanically ventilated patients, the most important, adverse consequences of respiratory-cardiovascular interactions are a PEEP-induced reduction in cardiac output, systemic oxygen delivery, and blood pressure; RV dysfunction in patients with ARDS; and acute hemodynamic collapse in patients with pulmonary hypertension. Read More

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Reduced risk of arterial thromboembolism in cats with pleural effusion due to congestive heart failure.

J Feline Med Surg 2022 Aug 13;24(8):e142-e152. Epub 2022 May 13.

Division of Internal Medicine, San Marco Veterinary Clinic, Veggiano (PD), Italy.

Objectives: The aim of the study was to determine whether cardiogenic pleural effusion in cats is associated with a lower risk of arterial thromboembolism (ATE) compared with cats with cardiac disease without evidence of pleural effusion.

Methods: A cross-sectional study was conducted on owned cats with natural occurring cardiac diseases. Cats included were classified in three groups: those with cardiac disease but no evidence of congestive heart failure (CHF); those with evidence of cardiogenic pulmonary oedema; and those with evidence of cardiogenic pleural effusion. Read More

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Handheld ultrasound as an adjunct to physical examination in the diagnosis of cardiopulmonary disease.

Robert J Henning

Future Cardiol 2022 Jul 11;18(7):585-600. Epub 2022 May 11.

University of South Florida, Tampa, FL 33612, USA.

Handheld 2D ultrasound devices (HUDs) have become available as an adjunct to physical examinations, visualizing the heart and lungs in real time and facilitating prompt patient diagnosis and treatment of cardiopulmonar.y disorders. These devices provide simple and rapid bedside alternatives to repetitive chest x-rays, standard ultrasound examinations and thoracic CT scans. Read More

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Left Atrial Decompression in Pediatric Patients Supported With Extracorporeal Membrane Oxygenation for Failure to Wean From Cardiopulmonary Bypass: A Propensity-Weighted Analysis.

J Am Heart Assoc 2022 May 10:e023963. Epub 2022 May 10.

Department of Cardiology Boston Children's HospitalHarvard Medical School Boston MA.

Background Left atrial (LA) decompression on extracorporeal membrane oxygenation (ECMO) can reduce left ventricular distension, allowing myocardial rest and recovery, and protect from lung injury secondary to cardiogenic pulmonary edema. However, clinical benefits remain unknown. We sought to evaluate the association between LA decompression and in-hospital adverse outcome (mortality, transplant on ECMO, or conversion to ventricular assist device) in patients who failed to wean from cardiopulmonary bypass using a propensity score to adjust for baseline differences. Read More

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Cardiomyopathy and heart failure secondary to anabolic-androgen steroid abuse.

Proc (Bayl Univ Med Cent) 2022 17;35(3):363-365. Epub 2022 Mar 17.

Department of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, Alabama.

Bodybuilders often use anabolic-androgenic steroids to improve performance. We report a case of a 30-year-old male bodybuilder with anabolic-androgen steroid abuse while getting ready for a bodybuilding contest. He had New York Heart Association class IV heart failure, severe nonischemic dilated cardiomyopathy, new-onset atrial fibrillation, cardiogenic pulmonary edema, and acute respiratory distress requiring mechanical ventilation. Read More

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Meta-Analysis of Point-of-Care Lung Ultrasonography Versus Chest Radiography in Adults With Symptoms of Acute Decompensated Heart Failure.

Am J Cardiol 2022 07 2;174:89-95. Epub 2022 May 2.

New York Presbyterian Hospital/Columbia University Irving Medical Center, Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, New York. Electronic address:

Acute decompensated heart failure (ADHF) is a primary cause of older adults presenting to the emergency department with acute dyspnea. Point-of-care lung ultrasound (LUS) has shown comparable or superior diagnostic accuracy in comparison with a chest x-ray (CXR) in patients presenting with symptoms of ADHF. The systematic review and meta-analysis aimed to elucidate the sensitivity and specificity of LUS in comparison with CXR for diagnosing ADHF and summarize the rapidly growing body of evidence in this domain. Read More

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Partial anomalous pulmonary venous connection with portosystemic shunt in a cat.

J Vet Cardiol 2022 Jun 4;41:220-226. Epub 2022 Apr 4.

Elle Animal Clinic, 1-5-12 Tokiwadai, Kitakami, 024-0012, Japan.

A nine-month-old castrated male domestic shorthair presented for evaluation with a three-month history of hematuria. Portosystemic shunts and calculi within the bladder were suspected, and computed tomography angiography was performed. Computed tomography angiography identified an extrahepatic portosystemic shunt and a partial anomalous pulmonary venous connection, with the lobar vein of the right caudal lobe draining into the caudal vena cava. Read More

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