1,993 results match your criteria Pulmonary Edema Cardiogenic


Neutrophil/lymphocyte ratio predicts in-hospital complications in Takotsubo syndrome. Results from a prospective multi-center registry.

Clin Cardiol 2020 Aug 8. Epub 2020 Aug 8.

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Background: Several hematological indices including subtypes of leukocytes populations have been associated with cardiovascular outcome. Takotsubo syndrome (TTS) is a form of acute heart failure syndrome featured by several in-hospital complications (IHCs).

Hypothesis: Hematological indices at admission may predict IHCs in TTS patients. Read More

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http://dx.doi.org/10.1002/clc.23442DOI Listing

Uncommon presentation of scorpion sting at teaching hospital.

J Family Med Prim Care 2020 May 31;9(5):2562-2565. Epub 2020 May 31.

Department of Medicine, AIIMS, Rishikesh, Uttarakhand, India.

Scorpion envenomation is a major public health problem in tropical and sub-tropical countries, especially in Africa, Middle East, Latin America, and India. Even though most of the scorpion envenomation are harmless, it is generally seen with a set of clinical features, such as pain, edema, numbness, and tenderness in the area of the sting but rarely have serious clinical sequelae with involvement of vital organ systems like cardiovascular system and respiratory system leading to fatal manifestations like acute pulmonary edema, acute heart failure, and acute respiratory distress syndrome (ARDS). Here we present a case of a 19-year-old village boy who developed myocarditis and cardiogenic shock following scorpion envenomation, which was successfully treated with vasopressors, non invasive ventilation, and other supportive care. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_310_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380751PMC

Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction.

Open Heart 2020 Aug;7(2)

Institut Hospital del Mar d' Investigacions Mediques, Barcelona, Spain.

Objective: Primary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI than younger patients despite their higher in-hospital morbimortality. The objective of this analysis was to determine the effectiveness of P-PCI in patients with STEMI ≥75 years. Read More

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http://dx.doi.org/10.1136/openhrt-2019-001169DOI Listing

Early Left Ventricular Thrombus Formation in a COVID-19 Patient with ST-Elevation Myocardial Infarction.

Case Rep Cardiol 2020 18;2020:8882463. Epub 2020 Jul 18.

University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham B15 2TH, UK.

Background: Left ventricular thrombus (LVT) is a complication of acute myocardial infarction (AMI) due to localised haemostasis. LVT is typically seen 3-12 days following AMI and is seldom seen within the first 24 hours. LVT increases the risk of mortality due to systemic thromboembolism. Read More

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http://dx.doi.org/10.1155/2020/8882463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369661PMC

Systemic Markers of Monocyte Activation in Acute Pulmonary Oedema.

Heart Lung Circ 2020 Jul 16. Epub 2020 Jul 16.

Intensive and Critical Care Unit, Flinders Medical Centre, Adelaide, SA, Australia; Department of Critical Care Medicine, Flinders University, Adelaide, SA, Australia.

Background: Hydrostatic lung injury followed by pulmonary remodelling variably complicates cardiogenic acute pulmonary oedema (APO). Pulmonary remodelling may be regulated by the balance between distinct phenotypes of pulmonary macrophages; activated/inflammatory (M1), and reparative/anti-inflammatory (M2), derived from circulating monocyte populations. The aim of this study was to identify biomarkers in peripheral blood that are consistent with hydrostatic lung injury and pulmonary remodelling in APO and which follow the variable clinical course. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.06.011DOI Listing

Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury.

Naunyn Schmiedebergs Arch Pharmacol 2020 Jul 21. Epub 2020 Jul 21.

Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.

Vascular endothelial growth factor (VEGF) is a prime regulator of vascular permeability. Acute lung injury (ALI) is characterized by high-permeability pulmonary edema in addition to refractory hypoxemia and diffuse pulmonary infiltrates. In this study, we examined whether VEGF can be implicated as a pulmonary vascular permeability factor in sepsis-associated ALI. Read More

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http://dx.doi.org/10.1007/s00210-020-01947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371837PMC

[Morphofunctional characteristic of the microvasculature of the lung tissue in acute fatal ethanol poisoning].

Sud Med Ekspert 2020 ;63(4):17-21

N.P. Bekhterev Institute of Human Brain of RAS, St. Petersburg, Russia.

The purpose of this work is an in-depth study of main morphological features and pathogenesis of acute lung injury in cases of acute fatal poisoning with ethanol; assessment of microcirculation disorders in the respiratory system; details of the mechanisms of development of non-cardiogenic pulmonary edema. An analysis of 160 deaths of men and women aged 19 to 85 years from acute ethanol poisoning was made. Histological preparations were colored with hematoxylin and eosin according to the Van Gieson method, elastic fibers - according to Weigert. Read More

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http://dx.doi.org/10.17116/sudmed20206304117DOI Listing
January 2020

Differences in 30-day complications and 1-year mortality by sex in patients with a first STEMI managed by the Codi IAM network between 2010 and 2016.

Rev Esp Cardiol (Engl Ed) 2020 Jul 10. Epub 2020 Jul 10.

Servicio de Cardiología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain; Departament de Salut, Generalitat de Catalunya, Barcelona, Spain.

Introduction And Objectives: ST-segment elevation myocardial infarction (STEMI) emergency care networks aim to increase reperfusion rates and reduce ischemic times. The influence of sex on prognosis is still being debated. Our objective was to analyze prognosis according to sex after a first STEMI. Read More

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http://dx.doi.org/10.1016/j.rec.2020.06.002DOI Listing

Crosstalk between brain, lung and heart in critical care.

Anaesth Crit Care Pain Med 2020 Jul 10. Epub 2020 Jul 10.

Department of anaesthesia and critical care, university hospital of Toulouse, university Toulouse 3 Paul Sabatier, Toulouse, France.

Extracerebral complications, especially pulmonary and cardiovascular, are frequent in brain-injured patients and are major outcome determinants. Two major pathways have been described: brain-lung and brain-heart interactions. Lung injuries after acute brain damages include ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS) and neurogenic pulmonary œdema (NPE), whereas heart injuries can range from cardiac enzymes release, ECG abnormalities to left ventricle dysfunction or cardiogenic shock. Read More

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http://dx.doi.org/10.1016/j.accpm.2020.06.016DOI Listing

Persistent cardiac arrest caused by profound hypokalaemia after large-dose insulin injection in a young man with type 1 diabetes mellitus: successful rescue with extracorporeal membrane oxygenation and subsequent ventricular assist device.

Cardiovasc J Afr 2020 Jul 6;31:1-4. Epub 2020 Jul 6.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Email:

A 28-year-old man who had a history of type 1 diabetes mellitus with poor medication compliance was referred to the emergency department of our institute with suspected diabetic ketoacidosis. The patient developed sudden cardiac arrest following continuous insulin administration. Laboratory data revealed severe hypokalaemia. Read More

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http://dx.doi.org/10.5830/CVJA-2020-018DOI Listing

Benefits of High-Flow Nasal Cannula Therapy for Acute Pulmonary Edema in Patients with Heart Failure in the Emergency Department: A Prospective Multi-Center Randomized Controlled Trial.

J Clin Med 2020 Jun 21;9(6). Epub 2020 Jun 21.

Department of Emergency Medicine, Yonsei University College of Medicine, Seoul 06273, Korea.

Heart failure patients with pulmonary edema presenting to the emergency department (ED) require an effective approach to deliver sufficient oxygen and reduce the rate of intubation and mechanical ventilation in the ED; conventional oxygen therapy has proven ineffective in delivering enough oxygen to the tissues. We aimed to identify whether high-flow nasal cannula (HFNC) therapy over time improved the respiratory rate (RR), lactate clearance, and certain arterial blood gas (ABG) parameters, in comparison with conventional oxygen therapy, in patients with cardiogenic pulmonary edema. This prospective, multi-institutional, and interventional study (clinical trial, reference KCT0004578) conducted between 2016 and 2019 included adult patients diagnosed with heart failure within the previous year and pulmonary edema confirmed at admission. Read More

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http://dx.doi.org/10.3390/jcm9061937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355695PMC

Effect of chest ultrasound on diagnostic workup in elderly patients with acute respiratory failure in the emergency department: a prospective study.

Eur J Emerg Med 2020 Jun 17. Epub 2020 Jun 17.

Emergency Department.

Diagnostic assessment of acute respiratory failure in elderly patients is often challenging, and initial misdiagnosis is associated with poorer outcomes. Chest ultrasound could help to improve diagnostic performance in this population. The objective of our study was to assess chest ultrasound (i. Read More

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http://dx.doi.org/10.1097/MEJ.0000000000000732DOI Listing

Non-Invasive Ventilatory Support In the Elderly.

Curr Geriatr Rep 2019 Sep 13;8(3):153-159. Epub 2019 Jun 13.

Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Mail Location 0558, Cincinnati, Ohio 45267-0558.

Purpose Of Review: The first description of non-invasive ventilation use began in the 1920s. Since then, its role in patient care has evolved through increased clinical knowledge and scientific advancements. The utilization of non-invasive ventilation has broadened from initial application in acute in-hospital ICU settings to now include the outpatient settings. Read More

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http://dx.doi.org/10.1007/s13670-019-00287-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274080PMC
September 2019

Noninvasive Positive Pressure Ventilation for Acute Decompensated Heart Failure.

Authors:
Michinari Hieda

Heart Fail Clin 2020 Jul;16(3):271-282

University of Texas Southwestern Medical Center, Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Avenue, Dallas, TX 75231, USA; Kyushu University, School of Medicine, Department of Medicine and Biosystemic Science, Division of Cardiology, 3-1-1 Maidashi Higashi-ku Fukuoka City, Clinical Research Building B6F Fukuoka, Zip:812-8582, Japan. Electronic address:

Noninvasive positive pressure ventilation (NIPPV), which can be applied without endotracheal airway or tracheostomy, has been used as the first-line device for patients with acute decompensated heart failure (ADHF) and cardiogenic pulmonary edema. Positive airway pressure (PAP) devices include continuous PAP, bilevel PAP, and adaptive servoventilation. NIPPV can provide favorable physiologic benefits, including improving oxygenation, respiratory mechanics, and pulmonary and systemic hemodynamics. Read More

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http://dx.doi.org/10.1016/j.hfc.2020.02.005DOI Listing

Flow-safe disposable CPAP efficiency in cardiogenic pulmonary oedema.

Am J Emerg Med 2020 Aug 28;38(8):1684. Epub 2020 Apr 28.

Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.

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http://dx.doi.org/10.1016/j.ajem.2020.04.073DOI Listing

Indications for non-invasive ventilation in respiratory failure.

Rev Recent Clin Trials 2020 Jun 3. Epub 2020 Jun 3.

Department of Anesthesiology and Intensive Care, Fondazione Policlinico Universitario "A Gemelli" IRCCS - Università Cattolica del Sacro Cuore, Rome. Italy.

Background: Non-invasive ventilation (NIV) is increasingly being used to treat episodes of acute respiratory failure not only in critical care and respiratory wards, but also in emergency departments. The aim of this review is to summarize the current indications for the management of NIV for respiratory failure.

Methods: Current literature about the topic was reviewed and critically reported to describe the rationale and physiologic advantages of NIV in various situations of respiratory failure. Read More

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http://dx.doi.org/10.2174/1574887115666200603151838DOI Listing

Disparities of demographics, clinical characteristics, and hospital outcomes of AMI pilgrims vs non-pilgrims-tertiary center experience.

Egypt Heart J 2020 May 29;72(1):31. Epub 2020 May 29.

King Abdullah Medical City, Muzdallfa Road, Makkah, Saudi Arabia.

Background: Acute myocardial infarction (AMI) is usually caused by rupture of an atherosclerotic plaque leading to thrombotic occlusion of a coronary artery. Cardiovascular disease has recently emerged as the leading cause of death during hajj. Our aim is to demonstrate the AMI pilgrim's related disparities and comparing them to non-pilgrim patients. Read More

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http://dx.doi.org/10.1186/s43044-020-00068-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260330PMC

Acute Myocardial Ischemia Following Bee Sting in an Adolescent Male: A Case Report.

Am J Case Rep 2020 May 29;21:e922120. Epub 2020 May 29.

Division of Pediatric Critical Care, Children's Hospital of Illinois, Peoria, IL, USA.

BACKGROUND Epinephrine for anaphylactic shock is the standard life-saving treatment in the emergency department. Cardiac symptoms after epinephrine administration in a child with no prior cardiac history are often not suspected. We describe a presentation of diastolic cardiac dysfunction after anaphylaxis from a bee sting in an adolescent male. Read More

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http://dx.doi.org/10.12659/AJCR.922120DOI Listing

The Impact of Severity of Acute Respiratory Distress Syndrome Following Cardiac Arrest on Neurologic Outcomes.

Ther Hypothermia Temp Manag 2020 May 22. Epub 2020 May 22.

Department of Emergency Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.

The aim of this study was to evaluate the incidence and determinants of acute respiratory distress syndrome (ARDS) after cardiac arrest (CA). We conducted an observational, retrospective cohort study with consecutive adult out-of-hospital and in-hospital (occurred only in the emergency department, ED) CA survivors from our ED. Development of ARDS was identified by results of arterial blood gases, chest images, and transthoracic echocardiography according to the Berlin definition. Read More

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http://dx.doi.org/10.1089/ther.2019.0047DOI Listing

Endotracheal Surfactant Combined With Budesonide for Neonatal ARDS.

Front Pediatr 2020 5;8:210. Epub 2020 May 5.

Division of Neonatology, Department of Pediatrics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Acute respiratory distress syndrome (ARDS) is a clinical condition characterized by acute diffuse inflammatory lung injury and severe hypoxemia. In 2017, the Montreux Consensus defined diagnostic criteria for ARDS in the neonatal period. The management of ARDS includes strict adherence to lung-protective ventilation strategies and therapeutic agents to improve gas exchange. Read More

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http://dx.doi.org/10.3389/fped.2020.00210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214613PMC

The Physiologic Basis and Clinical Outcomes of Combined Impella and Veno-Arterial Extracorporeal Membrane Oxygenation Support in Cardiogenic Shock.

Authors:
Hoong Sern Lim

Cardiol Ther 2020 May 18. Epub 2020 May 18.

University Hospital Birmingham, Edgbaston, Birmingham, UK.

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides effective hemodynamic support in cardiogenic shock, but in some cases may be complicated by left ventricular (LV) distension and pulmonary edema. The Impella, a catheter-mounted microaxial pump has been used to unload the LV. Recent studies have compared the clinical outcomes of VA-ECMO to the combination of Impella and VA-ECMO. Read More

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http://dx.doi.org/10.1007/s40119-020-00175-6DOI Listing

Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs.

Front Vet Sci 2020 28;7:151. Epub 2020 Apr 28.

R&D, Ceva Santé Animale, Libourne, France.

Torasemide is a loop diuretic licensed in dogs for cardiogenic pulmonary oedema. The aim of this pharmacokinetic-pharmacodynamic (PK/PD) study was to define an optimally effective dosage regimen based on preclinical data. In a first study, 5 dogs received once-daily oral torasemide (0, 0. Read More

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http://dx.doi.org/10.3389/fvets.2020.00151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199743PMC

The GRACE Scale in the Prognosis of Patients with Takotsubo Syndrome.

J Interv Cardiol 2020 24;2020:4340930. Epub 2020 Apr 24.

Department of Invasive Cardiology, Medical University of Bialystok, Białystok, Poland.

Background: The prognosis of Takotsubo syndrome (TTS) is comparable to that of the non-ST-elevation myocardial infarction (NSTEMI). The GRACE scale is used to assess the risk of premature and long-term mortality in patients with NSTEMI in order to select the most favorable treatment strategy.

Methods: 101 patients with TTS hospitalized in four centers of invasive cardiology in Podlaskie Voivodeship during the period 2008-2012 were included in the study. Read More

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http://dx.doi.org/10.1155/2020/4340930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197005PMC

Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach.

Am J Physiol Lung Cell Mol Physiol 2020 06 13;318(6):L1239-L1243. Epub 2020 May 13.

Department of Anesthesiology, Duke University, Durham, North Carolina.

Lethality of coronavirus disease (COVID-19) during the 2020 pandemic, currently still in the exponentially accelerating phase in most countries, is critically driven by disruption of the alveolo-capillary barrier of the lung, leading to lung edema as a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We argue for inhibition of the transient receptor potential vanilloid 4 (TRPV4) calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. We believe that TRPV4 inhibition has a powerful prospect at protecting this vital barrier in COVID-19 patients, even to rescue a damaged barrier. Read More

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http://dx.doi.org/10.1152/ajplung.00161.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276984PMC

Flow-safe disposable CPAP efficiency in cardiogenic pulmonary oedema.

Am J Emerg Med 2020 Aug 29;38(8):1683-1684. Epub 2020 Apr 29.

Intensive Care Unit, Hospital Morales Meseguer, Avenida Marqués de Los Velez s/n, 30500 Murcia, Spain.

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http://dx.doi.org/10.1016/j.ajem.2020.04.081DOI Listing

[A review of studies on the pathogenesis and preclinical drug therapy of acute respiratory distress syndrome].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Mar;32(3):378-381

Department of Respiratory Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China. Corresponding author: Zhang Xianming, Email:

Acute respiratory distress syndrome (ARDS) is a serious disease with high mortality, which is characterized by non-cardiogenic pulmonary edema and hypoxemia. In recent years, the development of supportive therapy has reduced the mortality to some extent, however, the high cost of treatment, side effects and the high mortality of moderate and severe ARDS limit its efficacy. So it is necessary to strengthen the research on specific drugs. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20200107-00111DOI Listing

Pulmonary complications following cardiac surgery.

Arch Med Sci Atheroscler Dis 2019 31;4:e280-e285. Epub 2019 Dec 31.

Department of Cardiology, Yazd Cardiovascular Research Centre, Shahid Sadoughi University of Medical sciences, Yazd, Iran.

Coronary heart disease is a common diseases of atherosclerosis. Despite the development of noninvasive therapies and the advancement of pharmacological methods and extensive drug regimens, coronary artery bypass grafting surgery is still the ultimate treatment option in many patients. Among the various complications following open heart surgery, one of the common difficulties is pulmonary complications associated with subsequent morbidity and mortality, which should be studied according to preoperative, perioperative, and postoperative factors. Read More

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http://dx.doi.org/10.5114/amsad.2019.91432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191937PMC
December 2019

Noninvasive oxygenation strategies in adult patients with acute respiratory failure: a protocol for a systematic review and network meta-analysis.

Syst Rev 2020 Apr 26;9(1):95. Epub 2020 Apr 26.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

Background: Acute hypoxemic respiratory failure is one of the leading causes of intensive care unit admission and is associated with high mortality. Noninvasive oxygenation strategies such as high-flow nasal cannula, standard oxygen therapy, and noninvasive ventilation (delivered by either face mask or helmet interface) are widely available interventions applied in these patients. It remains unclear which of these interventions are more effective in decreasing rates of invasive mechanical ventilation and mortality. Read More

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http://dx.doi.org/10.1186/s13643-020-01363-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184712PMC

Comparison of cardiac output and cardiac index values measured by critical care echocardiography with the values measured by pulse index continuous cardiac output (PiCCO) in the pediatric intensive care unit:a preliminary study.

Ital J Pediatr 2020 Apr 16;46(1):47. Epub 2020 Apr 16.

Department of Biostatistics, Çukurova University Faculty of Medicine, Adana, Turkey.

Background: Planning optimal fluid and inotrope-vasopressor-inodilator therapy is essential in critically ill children. Pulse index Contour Cardiac Output (PiCCO) monitoring is an invasive, hemodynamic monitor that provides parameter measurements such as cardiac output (CO), cardiac index (CI). Use of ultrasonography and critical care echocardiography by the pediatric intensivists has increased in recent years. Read More

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http://dx.doi.org/10.1186/s13052-020-0803-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161263PMC

Noninvasive Positive Pressure Ventilation for Cardiogenic Pulmonary Edema.

Acad Emerg Med 2020 Apr 16. Epub 2020 Apr 16.

From the , Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1111/acem.13986DOI Listing

High-Flow Nasal Cannula in Early Emergency Department Management of Acute Hypercapnic Respiratory Failure Due to Cardiogenic Pulmonary Edema.

Respir Care 2020 Apr 14. Epub 2020 Apr 14.

Department of Emergency Medicine and Prehospital Care, Montpellier University Hospital, Montpellier, France.

Background: Noninvasive ventilation (NIV) is the recommended ventilatory support for acute cardiogenic pulmonary edema (CPE) associated with acute respiratory failure or hypercapnia. High-flow nasal cannula (HFNC) has emerged as an alternative to NIV in acute hypoxemic respiratory failure. We aimed to assess the efficacy of HFNC on early changes in P and respiratory parameters in patients in the emergency department with acute hypercapnic CPE and to compare it to NIV. Read More

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http://dx.doi.org/10.4187/respcare.07278DOI Listing

Validation of the diagnosis and triage algorithm for acute myocardial infarction in the setting of left bundle branch block.

Am J Emerg Med 2020 Mar 19. Epub 2020 Mar 19.

Department of Emergency Medicine, Chang Gung Memorial Hospital, No.6, W. Sec., Jiapu Rd., Puzih City, Chiayi County 613, Taiwan; Chang Gung University College of Medicine, No.5, Fusing St., Gueishan Township, Taoyuan County 333, Taiwan. Electronic address:

Background: Detecting acute ST-segment elevation myocardial infarction (STEMI) in the setting of left bundle branch block (LBBB) remains a challenge to clinicians. Several diagnostic and triage algorithms have been proposed to accurately identify LBBB patients with an acute culprit vessel. We aimed to validate the algorithm proposed by Cai et al. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.03.024DOI Listing

Should Noninvasive Ventilation Be Used for Treatment of Acute Cardiogenic Pulmonary Edema? A Cochrane Review Summary With Commentary.

Authors:
Dean R Hess

Respir Care 2020 04;65(4):573-574

Massachusetts General Hospital and Northeastern University, Boston, MA. He is also Managing Editor of Respiratory Care.

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http://dx.doi.org/10.4187/respcare.07685DOI Listing

ISCCM Guidelines for the Use of Non-invasive Ventilation in Acute Respiratory Failure in Adult ICUs.

Indian J Crit Care Med 2020 Jan;24(Suppl 1):S61-S81

Department of Division of Critical Care Medicine, Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India, , e-mail:

A. ACUTE HYPERCAPNIC RESPIRATORY FAILURE A1. Acute Exacerbation of COPD: Recommendations: NIV should be used in management of acute exacerbation of COPD in patients with acute or acute-on-chronic respiratory acidosis (pH = 7. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-G23186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085817PMC
January 2020

Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation.

Toxins (Basel) 2020 03 5;12(3). Epub 2020 Mar 5.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo 14040-903, Brazil.

causes numerous scorpion envenomation accidents and deaths worldwide. The symptoms vary from local to systemic manifestations, culminating in pulmonary edema and cardiogenic shock. Among these events, transitory hyperglycemia is a severe manifestation that influences pulmonary edema, hemodynamic alterations, and cardiac disturbances. Read More

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http://dx.doi.org/10.3390/toxins12030163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150851PMC

Hydrochlorothiazide-induced systemic capillary leak.

Authors:
Peter Vadas

Am J Emerg Med 2020 06 19;38(6):1299.e1-1299.e2. Epub 2020 Feb 19.

Division of Clinical Immunology and Allergy, Department of Medicine, St. Michael's Hospital, University of Toronto, Canada. Electronic address:

Hypersensitivity reactions to drugs may cause very rapid physiologic derangements that can be fatal in the absence of adequate compensatory mechanisms or definitive treatment. For the most part, adverse drug reactions that progress over the course of minutes are mediated either by mast cell or complement activation. If a patient survives the acute event, appropriate long-term management requires the identification and future avoidance of the inciting drug. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.02.029DOI Listing

Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE).

Acta Physiol (Oxf) 2020 Jun 16;229(2):e13461. Epub 2020 Mar 16.

Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.

Aim: High-altitude pulmonary oedema (HAPE) is a non-cardiogenic pulmonary oedema that can occur during rapid ascent to a high-altitude environment. Classically, HAPE has been described as a condition resulting from a combination of pulmonary vasoconstriction and hypertension. Inflammation has been described as important in HAPE, although as a side effect of pulmonary oedema rather than as a causative factor. Read More

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http://dx.doi.org/10.1111/apha.13461DOI Listing

Scorpion envenomation: state of the art.

Intensive Care Med 2020 03 3;46(3):401-410. Epub 2020 Mar 3.

Research Lab, Cardiopulmonary Research in Intensive Care and Toxicology, LR12SP15, Monastir, Tunisia.

Scorpion envenomation is common in the tropical and subtropical regions. It poses a major public health problem with some patients having serious clinical manifestations and severe complications including death. Old World and New World scorpions are usually contrasted because of differences in venom composition, clinical presentation and severity, and, accordingly, different therapeutic approaches. Read More

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http://dx.doi.org/10.1007/s00134-020-05924-8DOI Listing
March 2020
7.214 Impact Factor

The unknown known: non-cardiogenic pulmonary edema in amlodipine poisoning, a cohort study.

Clin Toxicol (Phila) 2020 Mar 2:1-8. Epub 2020 Mar 2.

Swedish Poisons Information Center, Stockholm, Sweden.

Amlodipine is the most common calcium channel blocker (CCB) on the Swedish market, and poison center (PC) consultations for amlodipine overdoses are increasing. The clinical picture is dominated by vasodilation with relative preservation of cardiac function. CCBs selectively dilate vessels on the afferent side of the capillary network which, in states of preserved or increased blood flow may lead to edema formation, including non-cardiogenic pulmonary edema (NCPE). Read More

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http://dx.doi.org/10.1080/15563650.2020.1725034DOI Listing

Remote wireless vital signs monitoring on the ward for early detection of deteriorating patients: A case series.

Int J Nurs Stud 2020 Apr 3;104:103515. Epub 2020 Jan 3.

Department of Anaesthesiology, Amsterdam UMC, location AMC, H1-148, Amsterdam UMC, location AMC, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. Electronic address:

Introduction: Remote wireless monitoring is a new technology that allows the continuous recording of ward patients' vital signs, supporting nurses by measuring vital signs frequently and accurately. A case series is presented to illustrate how these systems might contribute to improved patient surveillance.

Methods And Results: Five hospitals in three European countries installed a remote wireless vital signs monitoring system on medical or surgical wards. Read More

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http://dx.doi.org/10.1016/j.ijnurstu.2019.103515DOI Listing

Usefulness of pericardial lung ultrasonography for the diagnosis of cardiogenic pulmonary edema in dogs.

Am J Vet Res 2020 Mar;81(3):227-232

Objective: To investigate whether lung ultrasonography (LUS) performed around the heart, where the lungs are in contact with the pericardium (ie, pericardial LUS), could be used for the diagnosis of cardiogenic pulmonary edema (CPE) in dogs with degenerative mitral valve disease (DMVD).

Animals: 15 control dogs with healthy hearts and 26 dogs with DMVD.

Procedures: In a prospective multicenter study design, dogs with DMVD were assigned to 2 groups: those with CPE (n = 11) and those without CPE (15). Read More

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http://dx.doi.org/10.2460/ajvr.81.3.227DOI Listing

Breaking hearts and taking names: A case of sarcoidosis related effusive-constrictive pericarditis.

Respir Med 2020 03 23;163:105879. Epub 2020 Jan 23.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Introduction: Pericardial involvement of sarcoidosis is a rare cause for acute heart failure, and usually occurs as a result of the development of a pericardial effusion leading to cardiac tamponade. Even rarer still, is the manifestation of constrictive pericarditis. We report a case of sarcoidosis with lung, pleural, and pericardial involvement with effusive-constrictive pericarditis leading to cardiac tamponade. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105879DOI Listing

Positive Pressure Ventilation in Cardiogenic Shock: Review of the Evidence and Practical Advice for Patients With Mechanical Circulatory Support.

Can J Cardiol 2020 02 12;36(2):300-312. Epub 2019 Dec 12.

Department of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Cardiogenic shock (CS) is often complicated by respiratory failure, and more than 80% of patients with CS require respiratory support. Elevated filling pressures from left-ventricular (LV) dysfunction lead to alveolar pulmonary edema, which impairs both oxygenation and ventilation. The implementation of positive pressure ventilation (PPV) improves gas exchange and can improve cardiovascular hemodynamics by reducing preload and afterload of the LV, reducing mitral regurgitation and decreasing myocardial oxygen demand, all of which can help augment cardiac output and improve tissue perfusion. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.11.038DOI Listing
February 2020

Differences in presentation and clinical outcomes between left or right bundle branch block and ST segment elevation in patients with acute myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2020 Feb 7:2048872620905101. Epub 2020 Feb 7.

Division of Cardiology, Triemli Hospital Zurich, Switzerland.

Background: In patients with acute myocardial infarction, the presence of a left bundle branch block or right bundle branch block may be associated with worse prognosis compared to isolated ST segment elevation. However, specificities in clinical presentation and outcomes of acute myocardial infarction patients with left bundle branch block or right bundle branch block are poorly characterized.

Methods: We analysed acute myocardial infarction patients with left bundle branch block (=880), right bundle branch block (=732) or ST segment elevation without bundle branch block (=15,852) included in the Acute Myocardial Infarction in Switzerland-Plus registry between 2008-2019. Read More

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http://dx.doi.org/10.1177/2048872620905101DOI Listing
February 2020

The evolution of radiographic edema in ARDS and its association with clinical outcomes: A prospective cohort study in adult patients.

J Crit Care 2020 Apr 13;56:222-228. Epub 2020 Jan 13.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Center for Medicine and the Microbiome, University of Pittsburgh, USA. Electronic address:

Purpose: To assess the longitudinal evolution of radiographic edema using chest X-rays (CXR) in patients with Acute Respiratory Distress Syndrome (ARDS) and to examine its association with prognostic biomarkers, ARDS subphenotypes and outcomes.

Materials And Methods: We quantified radiographic edema on CXRs from patients with ARDS or cardiogenic pulmonary edema (controls) using the Radiographic Assessment of Lung Edema (RALE) score on day of intubation and up to 10 days after. We measured baseline plasma biomarkers and recorded clinical variables. Read More

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http://dx.doi.org/10.1016/j.jcrc.2020.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136845PMC

From bedside to bench: lung ultrasound for the assessment of pulmonary edema in animal models.

Cell Tissue Res 2020 May 3;380(2):379-392. Epub 2020 Feb 3.

Institute of Physiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Traditionally, the lung has been excluded from the ultrasound organ repertoire and, hence, the application of lung ultrasound (LUS) was largely limited to a few enthusiastic clinicians. Yet, in the last decades, the recognition of the previously untapped diagnostic potential of LUS in intensive care medicine has fueled its widespread use as a rapid, non-invasive and radiation-free bedside approach with excellent diagnostic accuracy for many of the most common causes of acute respiratory failure, e.g. Read More

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http://dx.doi.org/10.1007/s00441-020-03172-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210222PMC

Benefit and harm of intravenous vasodilators across the clinical profile spectrum in acute cardiogenic pulmonary oedema patients.

Eur Heart J Acute Cardiovasc Care 2020 Jan 29:2048872619891075. Epub 2020 Jan 29.

Tokyo CCU Network Scientific Committee, Japan.

Background: The absence of high quality, large-scale data that indicates definitive mortality benefits does not allow for firm conclusions on the role of intravenous vasodilators in acute heart failure. We aimed to investigate the associations between intravenous vasodilators and clinical outcomes in acute heart failure patients, with a specific focus on patient profiles and type of vasodilators.

Methods: Data of 26,212 consecutive patients urgently hospitalised for a primary diagnosis of acute heart failure between 2009 and 2015 were extracted from a government-funded multicentre data registration system. Read More

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http://dx.doi.org/10.1177/2048872619891075DOI Listing
January 2020

Comparison of high-flow nasal cannula oxygen therapy and non-invasive ventilation as first-line therapy in respiratory failure: a multicenter retrospective study.

Acute Med Surg 2020 Jan-Dec;7(1):e461. Epub 2019 Sep 27.

Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital Ube Yamaguchi Japan.

Aim: To identify which subgroups of respiratory failure could benefit more from high-flow nasal cannula oxygen therapy (HFNC) or non-invasive ventilation (NIV).

Methods: We undertook a multicenter retrospective study of patients with acute respiratory failure (ARF) who received HFNC or NIV as first-line respiratory support between January 2012 and December 2017. The adjusted odds ratios (OR) with 95% confidence intervals (CI) for HFNC versus NIV were calculated for treatment failure and 30-day mortality in the overall cohort and in patient subgroups. Read More

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http://dx.doi.org/10.1002/ams2.461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971449PMC
September 2019