24,148 results match your criteria Pulmonary Disease and Pregnancy


CT characteristics and diagnostic value of COVID-19 in pregnancy.

PLoS One 2020 2;15(7):e0235134. Epub 2020 Jul 2.

Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Objective: To investigate the computed tomography (CT) characteristics and diagnostic value of novel coronavirus pneumonia (NCP or COVID-19) in pregnancy.

Methods: This study included ten pregnant women infected with COVID-19, treated in the Zhongnan Hospital of Wuhan University from January 20, 2020 to February 6, 2020. Clinical and chest CT data were collected and clinical symptoms, laboratory indicators, and CT images were analyzed to explore CT characteristics and diagnostic value for COVID-19 during pregnancy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235134PLOS

Acute Fatty Liver Disease of Pregnancy in the Second Trimester.

Case Rep Crit Care 2020 15;2020:6705784. Epub 2020 Jun 15.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, College of Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100225, Gainesville, FL 32610-0225, USA.

Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically presents in the third trimester. We report a case of a 21-year-old woman with a history of intrauterine fetal demise at 19 weeks' gestation who developed fulminant liver failure 1 week after the fetal demise. She was diagnosed with AFLP as per the Swansea criteria. Read More

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http://dx.doi.org/10.1155/2020/6705784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315284PMC

No evidence of vertical transmission of SARS-CoV-2 after induction of labour in an immune-suppressed SARS-CoV-2-positive patient.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, Zuid-Holland, The Netherlands

We present a case of a 38+1 weeks pregnant patient (G1P0) with a proven COVID-19 infection, who was planned for induction of labour because of pre-existent hypertension, systemic lupus erythematosus, respiratory problem of coughing and mild dyspnoea without fever during the COVID-19 pandemic in March 2020. To estimate the risk of vertical transmission of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) during labour and delivery, we collected oropharyngeal, vaginal, urinary, placental and neonatal PCRs for SARS-CoV-2 during the period of admission. All PCRs, except for the oropharyngeal, were negative and vertical transmission was not observed. Read More

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http://dx.doi.org/10.1136/bcr-2020-235581DOI Listing

Prediction of adverse cardiac events in pregnant women with valvular rheumatic heart disease.

Heart 2020 Jun 29. Epub 2020 Jun 29.

Anaesthesiology & Critical Care, Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER), Puducherry, India.

Objective: To assess the incidence of adverse cardiac events in pregnant women with rheumatic valvular heart disease (RHD) and to derive a clinical risk scoring for predicting it.

Methods: This is an observational study involving pregnant women with RHD, attending a tertiary centre in south India. Data regarding obstetric history, medical history, maternal complications and perinatal outcome till discharge were collected. Read More

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http://dx.doi.org/10.1136/heartjnl-2020-316648DOI Listing

Diagnosis of deep vein thrombosis.

Rev Clin Esp 2020 Jun 26. Epub 2020 Jun 26.

Departamento de Medicina Interna, Hospital de Mollet, Barcelona, España. Electronic address:

Deep vein thrombosis (DVT) is part of the clinical spectrum of venous thromboembolism disease (VTE), whose estimated annual incidence rate is 1-2 episodes per 1000 individuals and represents the third leading cause of cardiovascular mortality in developed countries. Establishing an accurate diagnosis of DVT is essential for preventing acute complications (such as pulmonary embolism) and chronic complications associated with post-thrombotic syndrome. Currently, there are well-established diagnostic algorithms for lower extremity DVT, which include clinical probability models that help establish the risk of experiencing the disease based on the patients' history, clinical findings, D dimer measurements, fibrin degradation product tests with a high negative predictive value and imaging tests to confirm the diagnosis. Read More

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http://dx.doi.org/10.1016/j.rce.2020.03.009DOI Listing

Percutaneous mitral commissurotomy in women with asymptomatic severe mitral stenosis before pregnancy.

Acta Cardiol 2020 Jun 29:1-6. Epub 2020 Jun 29.

Department of Cardiology, Yüzüncü Yıl University, Van, Turkey.

Performing percutaneous mitral commissurotomy (PMC) in the women with asymptomatic severe mitral stenosis (MS) who plan a pregnancy is recommended. However the data regarding this recommendation is limited in the literature. We aimed to investigate maternal and fetal outcomes of women with asymptomatic severe MS who underwent PMC before a planned pregnancy. Read More

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http://dx.doi.org/10.1080/00015385.2020.1783778DOI Listing

Triiodothyronine for the treatment of critically ill patients with COVID-19 infection: A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 26;21(1):573. Epub 2020 Jun 26.

Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Ave.,11527 Goudi, Athens, Greece.

Objectives: Tissue hypoxia is the main cause of multi-organ dysfunction in sepsis. However, effective pharmacological treatments to combat sepsis-induced tissue hypoxia are not available. Emerging experimental and clinical evidence reveals an evolutionary conserved action of thyroid hormone (TH) to adapt injured tissue to hypoxic conditions via its action on p38 MAPK, Akt signaling pathways. Read More

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http://dx.doi.org/10.1186/s13063-020-04474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316579PMC

Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020.

MMWR Morb Mortal Wkly Rep 2020 Jun 26;69(25):769-775. Epub 2020 Jun 26.

CDC COVID-19 Emergency Response.

As of June 16, 2020, the coronavirus disease 2019 (COVID-19) pandemic has resulted in 2,104,346 cases and 116,140 deaths in the United States.* During pregnancy, women experience immunologic and physiologic changes that could increase their risk for more severe illness from respiratory infections (1,2). To date, data to assess the prevalence and severity of COVID-19 among pregnant U. Read More

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http://dx.doi.org/10.15585/mmwr.mm6925a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316319PMC

IMPACT OF COMORBIDITIES IN MEXICAN SARS-COV-2-POSITIVE PATIENTS: A RETROSPECTIVE ANALYSIS IN A NATIONAL COHORT.

Rev Invest Clin 2020 ;72(3):151-158

Deparment of Biochemistry and Foods, Faculty of Chemical Sciences, Benemérita Universidad Autónoma de Puebla, Pue., Mexico.

Background: The coronavirus disease 2019 outbreak is a significant challenge for health-care systems around the world.

Objective: The objective of the study was to assess the impact of comorbidities on the case fatality rate (CFR) and the development of adverse events in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Mexican population.

Materials And Methods: We analyzed the data from 13,842 laboratory-confirmed SARS-CoV-2 patients in Mexico between January 1, 2020, and April 25, 2020. Read More

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http://dx.doi.org/10.24875/RIC.20000207DOI Listing

Pregnant, uninfected, stressed, and confined in the COVID-19 period: what can we expect in the near future?

Rev Assoc Med Bras (1992) 2020 04;66(4):386-387

. Departamento de Obstetrícia, Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/1806-9282.66.4.386DOI Listing

Real-world in-hospital outcomes and potential predictors of heart failure in primigravid women with heart disease in Southwestern China.

BMC Pregnancy Childbirth 2020 Jun 23;20(1):372. Epub 2020 Jun 23.

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Little is known about the status of maternal, obstetric, and neonatal complications and the potential predictors of developing heart failure (HF) in mothers with underlying heart disease (HD) in Southwestern China.

Methods: The eligible records from the YiduCloud database from December 1, 2010 to December 31, 2019 were screened. The maternal clinical characteristics and the in-hospital outcomes were collected and compared in primigravid women with and without HD. Read More

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http://dx.doi.org/10.1186/s12884-020-03058-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310540PMC

Clinical Presentation and Outcomes of Pregnant Women with COVID-19: A Systematic Review and Meta-Analysis.

Clin Infect Dis 2020 Jun 23. Epub 2020 Jun 23.

The Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Rochester MN, USA.

Introduction: Descriptions of coronavirus disease-2019 (COVID-19) have focused on the non-pregnant adult population. This study aims to describe the clinical characteristics and perinatal outcomes of COVID-19 in pregnancy.

Methods: We searched databases from December 2019 to April 30th, 2020. Read More

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http://dx.doi.org/10.1093/cid/ciaa828DOI Listing
June 2020
8.886 Impact Factor

Excluding pregnancy from COVID-19 trials: Protection from harm or the harm of protection?

CMAJ 2020 06;192(23):E634

Maternal-fetal medicine physician, Mount Sinai Hospital (Sinai Health System), University of Toronto, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.75807DOI Listing

Variation in Patient Smoking Cessation Rates among Health Care Providers: An Observational Study.

Chest 2020 Jun 16. Epub 2020 Jun 16.

Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA; Center for Value-Based Care Research, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA. Electronic address:

Background: Physicians play a crucial role in providing smoking cessation counseling and medications. However, it is unknown whether individual physicians' approaches impact whether patients quit. We assessed patient quit rates within a national quality-improvement learning collaborative to document variation in quit rates at the physician, practice and health system level. Read More

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http://dx.doi.org/10.1016/j.chest.2020.05.599DOI Listing

Letter to the editor: efficacy of different methods of combination regimen administrations including dexamethasone, intravenous immunoglobulin, and interferon-beta to treat critically ill COVID-19 patients: a structured summary of a study protocol for a randomized controlled trial.

Trials 2020 Jun 19;21(1):549. Epub 2020 Jun 19.

Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.

Objectives: There is little information about Coronavirus Disease 2019 (COVID-19) management for critically ill patients. Most of these patients develop acute respiratory distress syndrome (ARDS) due to excessive inflammatory response and the ensuing cytokine storm. Anti-inflammatory drugs including corticosteroids can be used to effectively reduce the effect of this cytokine storm and lung damage. Read More

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http://dx.doi.org/10.1186/s13063-020-04499-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303932PMC

Explaining the experience of prenatal care and investigating the association between psychological factors with self-care in pregnant women during COVID-19 pandemic: a mixed method study protocol.

Reprod Health 2020 Jun 18;17(1):98. Epub 2020 Jun 18.

Department of Midwifery, Faculty of Nursing and Midwifery Islamic Azad University, Tabriz branch, Tabriz, Iran.

Background: Coronavirus disease 2019 (COVID-19) is a novel global public health emergency. Prenatal care (PNC) providing institutes should identify the needs and demands of pregnant women by optimizing the means of PNC services during the COVID-19 pandemic. The present study aims to: a) explain prenatal care experiences; b) assess the factors affecting self-care, and c) present a prenatal care guideline and Strategies to improve the PNC. Read More

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http://dx.doi.org/10.1186/s12978-020-00949-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301351PMC

Solely MRI-Guided Cardiac Catheterization for Assessment of Pulmonary Hypertension in a Pregnant Lady with Undiagnosed Congenital Heart Disease.

Case Rep Cardiol 2020 26;2020:3072869. Epub 2020 May 26.

Department of Radiology, Mitera Children's Hospital, Athens, Greece.

Pregnancy in women with complex congenital heart disease (CHD) can be poorly tolerated. Amongst pregnant women with CHD and pulmonary hypertension (PH), the mortality rate can be as high as 30%. Cardiac catheterization procedures for assessment of haemodynamics and pulmonary vascular resistance (PVR) are often required in this patient population for risk stratification. Read More

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http://dx.doi.org/10.1155/2020/3072869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277057PMC

Tunisian Recommendations for resumption of Reproductive Medicine activity in the Covid-19 pandemic.

Tunis Med 2020 May;98(5):343-347

The activity of the Reproductive Medicine poses a dilemma in this pandemic Covid-19. In fact, this is a theoretically non-emergency activity except for fertility preservation with oncological reasons. The majority of fertility societies in the world such as the American Society for Reproductive Medicine (ASRM) and the European Society of Human Reproduction and Embryology (ESHRE) recommended stopping the inclusion of new patients and continuing only the In Vitro Fertilization (IVF) cycles that have already been initiated by promoting Freeze-all as much as possible. Read More

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Routine vaccination during covid-19 pandemic response.

BMJ 2020 06 16;369:m2392. Epub 2020 Jun 16.

UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1136/bmj.m2392DOI Listing

Effects of COVID-19 Infection during Pregnancy and Neonatal Prognosis: What Is the Evidence?

Int J Environ Res Public Health 2020 Jun 11;17(11). Epub 2020 Jun 11.

Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal.

Background: This study's aims are to assess the current evidence presented in the literature regarding the potential risks of COVID-19 infection among pregnant women and consequent fetal transmission.

Methods: a systematic literature review assessing papers published in the most comprehensive databases in the field of health intended to answer the question, "What are the effects of COVID-19 infection during pregnancy, and what is the neonatal prognosis?"

Results: 49 papers published in 2020 were eligible, presenting low levels of evidence. A total of 755 pregnant women and 598 infants were assessed; more than half of pregnant women had C-sections (379/65%). Read More

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http://dx.doi.org/10.3390/ijerph17114176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313049PMC

Combating sars-cov-2 through lipoxins, proteasome, caveolin and nuclear factor-κb pathways in non-pregnant and pregnant populations.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):221-229. Epub 2020 Jun 5.

Department of Internal Medicine Firat University School of Medicine, Elazig, Turkey.

It can be misleading to think that the new severe acute respiratory syndrome coronavirus (SARS-CoV2) which has a very strong mutation and adaptation capabilities, uses only the angiotensin-converting enzyme II (ACE2) pathway to reach target cells. Despite all the precautions taken, the pandemic attack continues and the rapid increase in the number of deaths suggest that this virus has entered the cell through different pathways and caused damage through different mechanisms. The main reason why the ACE2 pathway comes to the fore in all scientific studies is that this receptor is located at the entry point of basic mechanisms that provide alveolo-capillary homeostasis. Read More

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Impact of COVID-19 as a vertical infection in late pregnancy.

Authors:
J S M Leung

Hong Kong Med J 2020 06 5;26(3):271-272. Epub 2020 Jun 5.

Cardiothoracic Surgery, St Paul's Hospital, Hong Kong.

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http://dx.doi.org/10.12809/hkmj208655DOI Listing

Asthma-like Symptoms in Young Children Increase the Risk of COPD.

J Allergy Clin Immunol 2020 Jun 11. Epub 2020 Jun 11.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This remains unexplored due to the lack of long-term prospective studies from infancy to the onset of COPD.

Objective: We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.05.043DOI Listing

COVID-19 and pregnancy: a review of current knowledge.

Infez Med 2020 Jun;28(suppl 1):46-51

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.

Background: Since December 2019, coronavirus disease 2019 (COVID-19) has become a major health problem that is spreading all over the world. Several viral infections such as SARS, MERS, and influenza have been associated with adverse pregnancy outcomes. The question arises whether pregnant women are at greater risk of complications related to COVID-19 compared to other people What complications should we expect in the fetuses whose mothers were infected?

Aims: This review aims to provide a summary of studies on symptoms of COVID-19 and the possible risks of COVID-19 among pregnant women, as well as complications in fetuses and neonates whose mothers were infected with COVID-19. Read More

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Emerging coronaviruses: first SARS, second MERS and third SARS-CoV-2: epidemiological updates of COVID-19.

Infez Med 2020 Jun;28(suppl 1):6-17

Halal Research Center of IRI, FDA, Tehran, Iran.

Since December 2019, the emergence of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection has been reported unexpectedly in Wuhan, China, with staggering infection speed across China and around the world. To date, seven known strains of HCoVs belonging to four genera (i.e. Read More

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Collateral damage of the covid-19 pandemic: a Dutch perinatal perspective.

BMJ 2020 06 12;369:m2326. Epub 2020 Jun 12.

Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Postbus 2060, 3000 CB Rotterdam, Netherlands.

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http://dx.doi.org/10.1136/bmj.m2326DOI Listing

Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II).

Trials 2020 Jun 12;21(1):520. Epub 2020 Jun 12.

Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, Hubei, China.

Objectives: To assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.

Trial Design: This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.

Participants: Twenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Read More

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http://dx.doi.org/10.1186/s13063-020-04380-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290137PMC
June 2020
2.117 Impact Factor

Dietary factors during pregnancy and atopic outcomes in childhood: a systematic review from the European Academy of Allergy and Clinical Immunology.

Pediatr Allergy Immunol 2020 Jun 10. Epub 2020 Jun 10.

Depts of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.

Rationale: Allergic diseases are an increasing public health concern and early life environment is critical to immune development. Maternal diet during pregnancy has been linked to offspring allergy risk. In turn, maternal diet is a potentially modifiable factor, which could be targeted as an allergy prevention strategy. Read More

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http://dx.doi.org/10.1111/pai.13303DOI Listing

Neglected Pulmonary Arterial Hypertension in Sickle Cell Anaemia during Prenatal Care.

Eur J Case Rep Intern Med 2020 8;7(6):001532. Epub 2020 Apr 8.

Department of Gynecology, Iran University of Medical Sciences, Tehran, Iran.

Pulmonary arterial hypertension (PAH) is one of the main complications of sickle cell disease (SCD) and imparts significant risk during pregnancy. Here, we report the outcome of undetected PAH in a pregnant woman with SCD. The patient presented with severe progressive dyspnoea with echocardiographic findings of high pressure in the pulmonary artery in the 37th week of pregnancy. Read More

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http://dx.doi.org/10.12890/2020_001532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279914PMC

"Women and children last"-effects of the covid-19 pandemic on reproductive, perinatal, and paediatric health.

BMJ 2020 06 10;369:m2287. Epub 2020 Jun 10.

Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.

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http://dx.doi.org/10.1136/bmj.m2287DOI Listing

Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 10;21(1):513. Epub 2020 Jun 10.

Section of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital University of Copenhagen, Hellerup, Denmark.

Objectives: The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and pre-emptive treatment of supra-infections can shorten hospitalisation duration for patients with COVID-19 (measured as "days alive and out of hospital" as the primary outcome), reduce the risk of non- invasive ventilation, treatment in the intensive care unit and death.

Trial Design: This is a multi-centre, randomised, Placebo-controlled, 2-arm ratio 1:1, parallel group double-blind study.

Participants: 226 participants are recruited at the trial sites/hospitals, where the study will take place in Denmark: Aalborg, Bispebjerg, Gentofte, Herlev, Hillerød, Hvidovre, Odense and Slagelse hospitals. Read More

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http://dx.doi.org/10.1186/s13063-020-04409-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284668PMC

Nonimmune Hydrops Fetalis-Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review.

J Clin Med 2020 Jun 8;9(6). Epub 2020 Jun 8.

Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland.

The aim of this paper is to review the outcomes and discuss the genetic and non-genetic aetiology of nonimmune hydrops fetalis in order to support differential ultrasound and genetic evaluations and family counselling. This single-centre study includes all cases of nonimmune hydrops fetalis diagnosed prenatally from 2009 to 2019. Two sources of data were used for this study (prenatal and neonatal) to compare and summarise the findings. Read More

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http://dx.doi.org/10.3390/jcm9061789DOI Listing

Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases.

Adv Rheumatol 2020 06 9;60(1):32. Epub 2020 Jun 9.

Pontifícia Universidade Católica de Campinas, Campinas, Brazil.

Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chronic immune-mediated inflammatory rheumatic diseases for decades. It is an appropriate time to review their immunomodulatory and anti-inflammatory mechanisms impact on disease activity and survival of systemic lupus erythematosus patient, including antiplatelet effect, metabolic and lipid benefits. Read More

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http://dx.doi.org/10.1186/s42358-020-00134-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282202PMC

Prone Positioning for Pregnant Women With Hypoxemia Due to Coronavirus Disease 2019 (COVID-19).

Obstet Gynecol 2020 Jun 9. Epub 2020 Jun 9.

Divisions of Maternal-Fetal Medicine and Pulmonary and Critical Care Medicine, Baylor College of Medicine, and the Division of Anesthesiology, Critical Care, and Pain Medicine, Department of Critical Care and Respiratory Care, the University of Texas MD Anderson Cancer Center, Houston, Texas.

The coronavirus disease 2019 (COVID-19) pandemic has prompted expanded use of prone positioning for refractory hypoxemia. Clinical trials have demonstrated beneficial effects of early prone positioning for acute respiratory distress syndrome (ARDS), including decreased mortality. However, pregnant women were excluded from these trials. Read More

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http://dx.doi.org/10.1097/AOG.0000000000004012DOI Listing

Obstetrics and COVID-19.

J Pak Med Assoc 2020 May;70(Suppl 3)(5):S104-S107

Senior Research Fellow, Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome corona virus 2 (SARS-Cov-2), an RNA virus which has caused pandemic in the whole world. It has put an unprecedented burden on healthcare system globally, and neither obstetricians nor labour rooms are spared as deliveries and caesarean sections cannot be postponed. There is a threat of collapse of healthcare system in maternity wards and labour rooms due to risk for transmission to healthy patients, obstetricians, midwives and other staff. Read More

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http://dx.doi.org/10.5455/JPMA.24DOI Listing

Maternal Predictors of Disparate Outcomes in Children With Single Ventricle Congenital Heart Disease.

J Am Heart Assoc 2020 Jun 9;9(12):e014363. Epub 2020 Jun 9.

Division of Pediatric Cardiology Department of Pediatrics University of Utah Salt Lake City UT.

Background Significant variability in morbidity and mortality persists for children with functionally single ventricle congenital heart disease (SV-CHD) despite standardization in medical and surgical care. We hypothesized that maternal health factors may be associated with an increased risk of poor outcomes in children with SV-CHD. Methods and Results This retrospective, observational, cohort study included term maternal-infant pairs with a diagnosis of SV-CHD who underwent surgical palliation from 2006 to 2015 at Primary Children's Hospital. Read More

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http://dx.doi.org/10.1161/JAHA.119.014363DOI Listing

Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study.

BMJ 2020 06 8;369:m2107. Epub 2020 Jun 8.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Objectives: To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants.

Design: Prospective national population based cohort study using the UK Obstetric Surveillance System (UKOSS).

Setting: All 194 obstetric units in the UK. Read More

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http://dx.doi.org/10.1136/bmj.m2107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277610PMC

Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: A structured summary of a study protocol for a randomized controlled trial.

Trials 2020 06 8;21(1):499. Epub 2020 Jun 8.

Columbia University Medical Center, New York, USA.

Objectives: The aim of this study is to evaluate the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in hospitalized adults with severe SARS-CoV-2 infection.

Trial Design: This is a prospective, single-center, phase 2, randomized, controlled trial that is blinded to participants and clinical outcome assessor.

Participants: Eligible participants include adults (≥ 18 years) with evidence of SARS-CoV-2 infection by PCR test of nasopharyngeal or oropharyngeal swab within 14 days of randomization, evidence of infiltrates on chest radiography, peripheral capillary oxygen saturation (SpO2) ≤ 94% on room air, and/or need for supplemental oxygen, non-invasive mechanical ventilation, or invasive mechanical ventilation, who are willing and able to provide written informed consent prior to performing study procedures or who have a legally authorized representative available to do so. Read More

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http://dx.doi.org/10.1186/s13063-020-04422-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276974PMC

The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial.

Trials 2020 Jun 8;21(1):498. Epub 2020 Jun 8.

Instituto de Salud Global de Barcelona, Barcelona, Spain.

Objectives: The primary objective is to determine the efficacy of a single dose of ivermectin, administered to low risk, non-severe COVID-19 patients in the first 48 hours after symptom onset to reduce the proportion of patients with detectable SARS-CoV-2 RNA by Polymerase Chain Reaction (PCR) test from nasopharyngeal swab at day 7 post-treatment. The secondary objectives are: 1.To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab at day 7 post treatment. Read More

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http://dx.doi.org/10.1186/s13063-020-04421-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276958PMC

Acute Respiratory Decompensation Requiring Intubation in Pregnant Women with SARS-CoV-2 (COVID-19).

AJP Rep 2020 Apr 4;10(2):e169-e175. Epub 2020 Jun 4.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, New York.

There is a current paucity of information about the obstetric and perinatal outcomes of pregnant novel coronavirus disease 2019 (COVID-19) patients in North America. Data from China suggest that pregnant women with COVID-19 have favorable maternal and neonatal outcomes, with rare cases of critical illness or respiratory compromise. However, we report two cases of pregnant women diagnosed with COVID-19 in the late preterm period admitted to tertiary care hospitals in New York City for respiratory indications. Read More

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http://dx.doi.org/10.1055/s-0040-1712925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272216PMC

Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 5;21(1):485. Epub 2020 Jun 5.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Objectives: The hypothesis of the study is that treatment with hydroxychloroquine sulphate in hospitalised patients with coronavirus disease 2019 (Covid-19) is safe and will accelerate the virological clearance rate for patients with moderately severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) when compared to standard care. Furthermore, we hypothesize that early treatment with hydroxychloroquine sulphate is associated with more rapid resolve of clinical symptoms as assessed by the National Early Warning Score 2 (NEWS2), decreased admission rate to intensive care units and mortality, and improvement in protein biomarker profiles (C-reactive protein, markers of renal and hepatic injury, and established cardiac biomarkers like cardiac troponin and B-type natriuretic peptide).

Trial Design: The study is a two-arm, open label, pragmatic randomised controlled group sequential adaptive trial designed to assess the effect on viral loads and clinical outcome of hydroxychloroquine sulphate therapy in addition to standard care compared to standard care alone in patients with established Covid-19. Read More

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http://dx.doi.org/10.1186/s13063-020-04420-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273378PMC

Vertical Transmission of SARS-CoV-2: What is the Optimal Definition?

Am J Perinatol 2020 06 5;37(8):769-772. Epub 2020 Jun 5.

Department of Pediatrics, University of California Davis Children's Hospital, Sacramento, California.

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http://dx.doi.org/10.1055/s-0040-1712457DOI Listing

Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review.

PLoS One 2020 4;15(6):e0234187. Epub 2020 Jun 4.

Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Background: COVID-19 has created an extraordinary global health crisis. However, with limited understanding of the effects of COVID-19 during pregnancy, clinicians and patients are forced to make uninformed decisions.

Objectives: To systematically evaluate the literature and report the maternal and neonatal outcomes associated with COVID-19. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234187PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272020PMC

Congenital cutaneous candidiasis associated with maternal peripartum candidemia.

Rev Iberoam Micol 2020 May 31. Epub 2020 May 31.

Instituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain; Unit of Pediatric Infectious Diseases, Department of Pediatrics, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre (imas12), School of Medicine, Universidad Complutense, Madrid, Spain; Spanish Translational Research Network in Pediatric Infectious Diseases (RITIP), Spain.

Background: Cutaneous congenital candidiasis (CCC) is a rare condition consisting of invasive fungal infection of the epidermis and dermis that mostly affects preterm infants. Maternal vaginal candidiasis is present in half of the cases, although the occurrence of invasive candidiasis during pregnancy or peripartum period is exceptional.

Case Report: We present the case of a full-term infant that was born by vacuum-assisted vaginal delivery to an apparently healthy 33 year-old woman with no history of intravenous drug use or vaginal candidiasis during pregnancy. Read More

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http://dx.doi.org/10.1016/j.riam.2020.02.002DOI Listing

A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):470. Epub 2020 Jun 3.

Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.

Objectives: SARS-CoV2 infection leads to a concomitant pulmonary inflammation. This inflammation is supposed to be the main driver in the pathogenesis of lung failure (Acute Respiratory Distress Syndrome) in COVID-19. Objective of this study is to evaluate the efficacy and safety of a single dose treatment with Tocilizumab in patients with severe COVID-19. Read More

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http://dx.doi.org/10.1186/s13063-020-04447-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267747PMC

Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):472. Epub 2020 Jun 3.

Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, School of Medicine, University of Cantabria, Av. Valdecilla, 25, 39008, Santander, Cantabria, Spain.

Background: SARS-CoV-2 infection presents a high transmission in the group of health professionals in Spain (12-15% infected). Currently there is no accepted chemoprophylaxis but hydroxychloroquine (HDQ) is known to inhibit the coronavirus in vitro. Our hypothesis is that oral administration of hydroxychloroquine to healthcare professionals can reduce the incidence and prevalence of infection as well as its severity in this group. Read More

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http://dx.doi.org/10.1186/s13063-020-04400-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268173PMC

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):466. Epub 2020 Jun 3.

Clinical Pharmacology Department, Clinical Trial Unit, La Paz University Hospital - IdiPAZ, Paseo de la Castellana, 261, 28046, Madrid, Spain.

Objectives: Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial. Read More

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http://dx.doi.org/10.1186/s13063-020-04436-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267766PMC

High Burden of Cardiac Disease in Pregnancy at a National Referral Hospital in Western Kenya.

Glob Heart 2020 Feb 7;15(1):10. Epub 2020 Feb 7.

Directorate of Reproductive Health, Moi Teaching and Referral Hospital, Eldoret, KE.

Background: Cardiac disease is a leading cause of non-obstetric maternal death worldwide, but little is known about its burden in sub-Saharan Africa.

Objectives And Methods: We conducted a retrospective case-control study of pregnant women admitted to a national referral hospital in western Kenya between 2011-2016. Its purpose was to define the burden and spectrum of cardiac disease in pregnancy and assess the utility of the CARPREG I and modified WHO (mWHO) clinical risk prediction tools in this population. Read More

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http://dx.doi.org/10.5334/gh.404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218778PMC
February 2020