22,732 results match your criteria Pulmonary Disease and Pregnancy


Outcomes of self-induced late pregnancy termination in women presenting to a tertiary hospital in the Eastern Cape Province, South Africa.

S Afr Med J 2018 Oct 26;108(11):965-971. Epub 2018 Oct 26.

Walter Sisulu University and Eastern Cape Department of Health, East London, South Africa.

Background: Little is known about the outcomes of self-induced pregnancy termination after 24 weeks' gestation, as previous studies have concentrated on outcomes before 24 weeks.

Objectives: To investigate the gestational age, misoprostol dosage, source of information on misoprostol, reasons for termination and outcomes of self-induced pregnancy termination after 24 weeks' gestation.

Methods: A quantitative, retrospective case series observational research design was utilised. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v108i11.12979DOI Listing
October 2018
1 Read

Proximal, Distal, and Contralateral Effects of Blood Flow Restriction Training on the Lower Extremities: A Randomized Controlled Trial.

Sports Health 2019 Jan 14:1941738118821929. Epub 2019 Jan 14.

Kerlan Jobe Institute, Los Angeles, California.

Background:: Blood flow restriction (BFR) training involves low-weight exercises performed under vascular occlusion via an inflatable cuff. For patients who cannot tolerate high-load exercises, BFR training reportedly provides the benefits of high-load regimens, with the advantage of less tissue and joint stress.

Hypothesis:: Low-load BFR training is safe and efficacious for strengthening muscle groups proximal, distal, and contralateral to tourniquet placement in the lower extremities. Read More

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http://dx.doi.org/10.1177/1941738118821929DOI Listing
January 2019

An Versus Toxicogenomic Investigation of Prenatal Exposures to Tobacco Smoke.

Appl In Vitro Toxicol 2018 Dec 18;4(4):379-388. Epub 2017 May 18.

School of Biosciences, Cardiff University, Museum Avenue, Cardiff, United Kingdom.

Approximately 1 million women smoke during pregnancy despite evidence demonstrating serious juvenile and/or adult diseases being linked to early-life exposure to cigarette smoke. Susceptibility could be determined by factors in previous generations, that is, prenatal or "maternal" exposures to toxins. Prenatal exposure to airborne pollutants such as mainstream cigarette smoke has been shown to induce early-life insults (i. Read More

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http://dx.doi.org/10.1089/aivt.2016.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326191PMC
December 2018

Three cases of multi-generational Gaucher disease and colon cancer from an Ashkenazi Jewish family: A lesson for cascade screening.

Mol Genet Metab Rep 2019 Mar 4;18:19-21. Epub 2019 Jan 4.

Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Gaucher disease (GD) is one of the commonest lysosomal storage diseases that is inherited in an autosomal recessive manner and affects 1 in 50,000 to 100,000 people in the general population. The frequency is much higher (1 in 500 to 1000) in people of Ashkenazi Jewish heritage due to a founder effect. GD is caused by decreased or absent activity of β-glucosidase with subsequent accumulation of the substrate glucosylceramide in macrophages due to genetic alterations in the gene. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321950PMC

Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.

Can J Public Health 2019 Jan 7. Epub 2019 Jan 7.

Air Quality Research Division, Environment and Climate Change Canada, 4905 Dufferin St, 4th Floor, Office 4S310, Toronto, ON, M3H 5T4, Canada.

Objectives: To estimate the proportion of the Canadian population that is more susceptible to adverse effects of ozone (O) and fine particle (PM) air pollution exposure and how this varies by health region alongside ambient concentrations of O and PM.

Methods: Using data from the census, the Canadian Community Health Survey, vital statistics and published literature, we generated cross-sectional estimates for 2014 of the proportions of the Canadian population considered more susceptible due to age, chronic disease, pregnancy, outdoor work, socio-economic status, and diet. We also estimated 2010-2012 average concentrations of O and PM. Read More

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http://link.springer.com/10.17269/s41997-018-0169-8
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http://dx.doi.org/10.17269/s41997-018-0169-8DOI Listing
January 2019
3 Reads

Potential nutraceutical and food additive properties and risks of coffee: a comprehensive overview.

Crit Rev Food Sci Nutr 2019 Jan 7:1-27. Epub 2019 Jan 7.

a Department of Animal Nutrition, College of Animal Sciences and Technology , Northwest A & F University , Yangling , Shaanxi Province , P.R. China.

Coffee is a composite mixture of more than a thousand diverse phytochemicals like alkaloids, phenolic compounds, vitamins, carbohydrates, lipids, minerals and nitrogenous compounds. Coffee has multifunctional properties as a food additive and nutraceutical. As a nutraceutical, coffee has anti-inflammatory, anti-oxidant, antidyslipidemic, anti-obesity, type-2 diabetes mellitus (DM), and cardiovascular diseases (CVD), which can serve for the treatment and prevention of metabolic syndrome and associated disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408398.2018.1
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http://dx.doi.org/10.1080/10408398.2018.1489368DOI Listing
January 2019
2 Reads

Vitamin D and childhood asthma: causation and contribution to disease activity.

Curr Opin Allergy Clin Immunol 2019 Jan 2. Epub 2019 Jan 2.

Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York, USA.

Purpose Of Review: To review the literature of the past 18 months (April 2017 through September, 2018) relating to vitamin D and childhood asthma.

Recent Findings: A combined analysis of two clinical trials of maternal vitamin D supplementation trials showed a significant protective effect of vitamin D supplementation trials in the primary prevention of asthma and recurrent wheeze up to age 3 years. Secondary analyses from these trials have also suggested that initial maternal vitamin D status could affect the response to supplementation during pregnancy, with the biggest protective effect in children born to mothers with initial 25hydroxyvitamin D (25OHD) levels of at least 30 ng/ml. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000509DOI Listing
January 2019
2 Reads

What is safe enough - asthma in pregnancy - a review of current literature and recommendations.

Asthma Res Pract 2018 27;4:11. Epub 2018 Dec 27.

1Faculty of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia.

Background: Although asthma is one of the most serious diseases causing complications during pregnancy, half of the women discontinue therapy thus diminishing the control of the disease, mostly due to the inadequate education and fear of adverse events. Sadly, this is sometimes encouraged by insufficiently educated physicians. Since the incidence and the prevalence of asthma is increasing, it is important to arouse the importance of proper asthma therapy during pregnancy. Read More

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http://dx.doi.org/10.1186/s40733-018-0046-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307305PMC
December 2018
1 Read

[Clinical characteristics and risk factors in pregnancy with severe community-acquired pneumonia].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):842-848

Department of Intensive Care Unit, Foshan Woman and Children Hospital, Southern Medical University, Foshan 528000, China.

To analyze clinical characteristics of severe community-acquired pneumonia during pregnancy and its outcomes, and to explore the relevant risk factors. From September 2012 to September 2017, 324 398 pregnancies admitted in 7 tertiary hospitals were included. Clinical data of 33 cases of pregnancies with severe community-acquired pneumonia (severe pneumonia group) and 214 cases of pregnancies with common community-acquired pneumonia (control group) were reviewed retrospectively, including the clinical information, manifestations, laboratory examinations and pregnancy outcomes. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.008DOI Listing
December 2018
2 Reads

Neonatal and Maternal Outcomes in Pregnant Women With Cardiac Disease.

J Am Heart Assoc 2018 Nov;7(21):e009395

1 Division of Cardiovascular Medicine Department of Medicine State University of New York Stony Brook University Medical Center Stony Brook NY.

Background Pregnant women with underlying heart disease ( HD ) are at increased risk for adverse maternal, obstetric, and neonatal outcomes. Methods and Results Inpatient maternal delivery admissions and linked neonatal stays for women with cardiomyopathy, adult congenital HD, pulmonary hypertension ( PH ), and valvular HD were explored utilizing the Statewide Planning and Research Cooperative System (New York), January 1, 2000, through December 31, 2014, with the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). Maternal major adverse cardiac events, neonatal adverse clinical events ( NACE ), and obstetric complications were recorded. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009395
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http://dx.doi.org/10.1161/JAHA.118.009395DOI Listing
November 2018
2 Reads
2.882 Impact Factor

Pregnancy unmasking symptoms of undiagnosed lymphangioleiomyomatosis: Case report and review of literature.

Respir Med Case Rep 2019 23;26:63-67. Epub 2018 Nov 23.

Centegra Health Care System, USA.

Cystic lung diseases are a group of disorders that appear similar on radiological studies on chest computed tomography. Each disorder is characterized by its own etiology, pathophysiology, course of progression and manifestation. Lymphangioleiomyomatosis (LAM) is one of the cystic lung diseases that can either be hereditary or sporadic. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277247PMC
November 2018
1 Read

Using the emergency department to investigate smoking in young adults.

Ann Epidemiol 2018 Nov 24. Epub 2018 Nov 24.

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA.

Purpose: Smoking in young adults identifies the population at risk for future tobacco-related disease. We investigated smoking in a young adult population and within high-risk groups using emergency department (ED) data in a metropolitan area.

Methods: Using the electronic health record, we performed a retrospective study of smoking in adults aged 18-30 years presenting to the ED. Read More

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http://dx.doi.org/10.1016/j.annepidem.2018.11.007DOI Listing
November 2018
2.000 Impact Factor

[Pulmonary glial heterotopia: Unique lesion in an infant with anencephalic twin].

Ann Pathol 2018 Dec 12. Epub 2018 Dec 12.

Service de pathologie, hôpital universitaire Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Université Diderot Paris 7 - SPC, 16, rue Huchard, 75018 Paris, France.

Pulmonary glial heterotopia is an extremely rare entity whose pathophysiology remains unclear. We report for the first time one case of pulmonary glial heterotopia occured in a one-month baby free from any malformation. She has the particularity of being born from monozygotic monochorionic twin pregnancy where her anencephalic exencephalic sister suffered a medical termination of pregnancy. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.08.006DOI Listing
December 2018

Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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http://link.springer.com/10.1007/s10995-018-2652-5
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http://dx.doi.org/10.1007/s10995-018-2652-5DOI Listing
December 2018
4 Reads

The Differences Between Childhood and Adult Onset Antiphospholipid Syndrome.

Front Pediatr 2018 27;6:362. Epub 2018 Nov 27.

Department of Rheumatology, University College London, London, United Kingdom.

Antiphospholipid syndrome (APS) is a rare autoimmune disease of unknown etiology that represents a leading cause of acquired thromboembolism and recurrent miscarriage. It is characterized by the persistent elevated presence of pathogenic antiphospholipid auto-antibodies directed against cardiolipin, ß2-glycoprotein-I, and/or a positive lupus anticoagulant test. As with many autoimmune disorders, the pathogenesis of APS is believed to be the result of a complex interaction between environmental triggers and genetic predisposition. Read More

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http://dx.doi.org/10.3389/fped.2018.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277799PMC
November 2018
1 Read

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
12 Reads

The toxicology of air pollution predicts its epidemiology.

Inhal Toxicol 2018 Dec 5:1-8. Epub 2018 Dec 5.

a The National Health and Environmental Effects Research Laboratory , Environmental Protection Agency , Chapel Hill , NC , USA.

The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures. Humic-like substances (HULIS) have been identified as a chemical component common to cigarette smoke and air pollution particles. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1530316DOI Listing
December 2018
17 Reads

Maternal/Perinatal Outcome in Women with Sickle Cell Disease: A Comparison of Two Time Periods.

South Med J 2018 Dec;111(12):742-745

From the Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, the Department of Obstetrics and Gynecology of the University of Mississippi Medical Center, Jackson, and Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City.

Objective: To compare pregnancy outcomes in women with sickle cell disease from recent deliveries with a similar group delivered earlier.

Methods: During a 12-year period (2005-2016), data from pregnant women with hemoglobin SS or SC were collected from three university medical centers and compared with earlier studies (1979-2003) involving similar patients. The primary endpoints were maternal complications during pregnancy and newborn outcomes. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000900DOI Listing
December 2018
1 Read

A case-control study on pregnancy in Italian Cystic Fibrosis women. Data from the Italian Registry.

Respir Med 2018 Dec 13;145:200-205. Epub 2018 Nov 13.

Centro di supporto per la fibrosi cistica, Regione Lombardia, Brescia, Italy.

Background: Pregnancy in CF women is no longer an exceptional event, but few information on its effect on clinical status in European CF patients are available. This study describes Italian CF pregnant population, to investigate its effect on CF woman.

Methods: Data were collected (2010-2015) by the Italian CF Registry. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.11.009DOI Listing
December 2018

Endocrine regulation of lung disease and inflammation.

Exp Biol Med (Maywood) 2018 Dec 3:1535370218816653. Epub 2018 Dec 3.

1 Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Impact Statement: Sex-differences in the incidence and severity of inflammatory lung diseases have been recognized for years. Women of reproductive age are more likely to suffer from chronic lung disease, with higher mortality rates than men. Physiological changes in hormone levels such as those occurring during the menstrual cycle, pregnancy, and menopause have been associated with lung function changes and asthma symptoms. Read More

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http://dx.doi.org/10.1177/1535370218816653DOI Listing
December 2018
2 Reads

Prenatal exposure to PM and Congenital Heart Diseases in Taiwan.

Sci Total Environ 2019 Mar 20;655:880-886. Epub 2018 Nov 20.

Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan. Electronic address:

Gestational exposure to ambient air pollution has been associated with Congenital Heart Diseases (CHDs). However, only a few studies, with inconsistent results, have investigated the effects of PM exposure during early pregnancy. This study aims to evaluate the association between prenatal exposure to PM and CHDs occurrence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697183464
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http://dx.doi.org/10.1016/j.scitotenv.2018.11.284DOI Listing
March 2019
7 Reads

Detecting pulmonary edema in multiple pregnancy through point-of-care lung ultrasonography.

Authors:
J Gu L L Luo

Int J Obstet Anesth 2018 Oct 24. Epub 2018 Oct 24.

Department of Anesthesiology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijoa.2018.10.008DOI Listing
October 2018

Risk of adverse maternal and fetal outcomes during pregnancy in living kidney donors: A matched cohort study.

Clin Transplant 2018 Nov 25:e13453. Epub 2018 Nov 25.

Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado.

Background: We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls.

Methods: Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery system. Adverse pregnancy outcomes were defined as preterm delivery (delivery <37 weeks), delivery via cesarean section, gestational hypertension, preeclampsia/eclampsia, gestational diabetes, length of stay in the hospital >3 days, infant death/transfer to acute facility and low birthweight (<2500 g). Read More

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http://dx.doi.org/10.1111/ctr.13453DOI Listing
November 2018
1 Read

Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD.

Respir Res 2018 Nov 21;19(1):229. Epub 2018 Nov 21.

Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, 575 Children's Cross Road, Columbus, OH, USA.

Background: Hyperoxia is a frequently employed therapy for prematurely born infants, induces lung injury and contributes to development of bronchopulmonary dysplasia (BPD). BPD is characterized by decreased cellular proliferation, cellular migration, and failure of injury repair systems. Actin binding proteins (ABPs) such as VASP, cofilin1, and profilin1 regulate cell proliferation and migration via modulation of actin dynamics. Read More

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http://dx.doi.org/10.1186/s12931-018-0938-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249974PMC
November 2018
7 Reads

Caring for adults with congenital heart disease in a regional setting.

Aust J Rural Health 2018 Dec 19;26(6):441-446. Epub 2018 Nov 19.

Coffs Harbour Health Campus, Coffs Harbour, New South Wales, Australia.

Objective: The number of adults with congenital heart disease has increased with improvements in surgical and medical management, posing a challenge for regional and rural settings, which might have difficulties accessing specialised professionals with congenital heart disease services. This study aims to ascertain the demographics and management of adults with congenital heart disease seen by a cardiology practice in regional Australia to better understand the needs of regional adults with congenital heart disease.

Design: A descriptive study using data from clinical notes collected between April 2013 and April 2016. Read More

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http://doi.wiley.com/10.1111/ajr.12446
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http://dx.doi.org/10.1111/ajr.12446DOI Listing
December 2018
10 Reads

Autosomal recessive polycystic kidney disease (ARPKD) in a Nigerian newborn: a case report.

Pan Afr Med J 2018 25;30:172. Epub 2018 Jun 25.

Department of Paediatrics and Child Health, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Nigeria.

Autosomal recessive polycystic kidney disease (ARPKD) is a rare genetic disorder but even rarer in Africans and it is one of the causes of nephropathies in childhood. Although isolated cases of adult PKD have been reported in Nigerians; to the best of our knowledge, this case is the first to be reported in the paediatric age group in Nigeria. A case of autosomal recessive polycystic kidney disease presenting with severe perinatal asphyxia and severe respiratory distressis here by presented. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.172.15202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235478PMC
December 2018
2 Reads

Pulmonary Hypertension in Women.

Heart Fail Clin 2019 Jan 24;15(1):137-145. Epub 2018 Oct 24.

Division of Cardiovascular Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.

Prevalence of pulmonary arterial hypertension (PAH) is higher in women, and the mechanism remains unclear. Prognosis is overall better for female compared with male patients with PAH. Pregnancy is associated with significant risk, mortality, and morbidity in patients with PAH; consensus guidelines recommend against pregnancy and counsel about early termination in these patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15517136183007
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http://dx.doi.org/10.1016/j.hfc.2018.08.013DOI Listing
January 2019
8 Reads
1.408 Impact Factor

Successful pregnancy in a patient with pulmonary renal syndrome double-positive for anti-GBM antibodies and p-ANCA
.

Clin Nephrol 2018 Nov 15. Epub 2018 Nov 15.

Background: Antiglomerular basement membrane (anti-GBM) antibody disease is a rare condition causing pulmonary hemorrhage and necrotizing glomerulonephritis (pulmonary renal syndrome).

Case: We report a 30-year-old woman who presented with life-threatening pulmonary hemorrhage and an active urinary sediment, with normal glomerular filtration rate in the 13th week of pregnancy. Anti-GBM antibodies in serum were negative, but perinuclear antineutrophil cytoplasmatic antibodies (p--ANCA) were detected. Read More

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http://dx.doi.org/10.5414/CN109584DOI Listing
November 2018
2 Reads

Early fetal echocardiography.

Birth Defects Res 2018 Nov 14. Epub 2018 Nov 14.

Fetal & Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, Stollery Children's Hospital, Edmonton, Alberta, Canada.

Objectives: To explore the technical aspects and clinical utility of early fetal echocardiography and screening of the fetal heart in early pregnancy. Also, to document differences in cardiac structure and function which can be demonstrated in the late first/early second trimesters.

Methods: In addition to summarizing our own experiences of late first/early second trimester fetal echocardiography, we reviewed the literature to explore clinical indications for, technical aspects, safety, accuracy, strengths and weaknesses of early fetal echocardiography. Read More

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http://doi.wiley.com/10.1002/bdr2.1414
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http://dx.doi.org/10.1002/bdr2.1414DOI Listing
November 2018
8 Reads

Use of tumor necrosis factor-alpha inhibitors during pregnancy among women who delivered live born infants.

Pharmacoepidemiol Drug Saf 2018 Nov 14. Epub 2018 Nov 14.

Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Purpose: To describe the use of tumor necrosis factor-alpha inhibitors (TNFis) among pregnancies ending in a live birth and with a diagnosis of ankylosing spondylitis (AS), Crohn's disease (CD), juvenile idiopathic arthritis (JIA), psoriasis (PsO), psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ulcerative colitis (UC).

Methods: We identified pregnancies among women aged 15 to 54 years between 01/01/2004 and 09/30/2015 from 16 health plans participating in Sentinel. We inferred indication using ICD-9-CM codes in the 183-day period before conception. Read More

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http://dx.doi.org/10.1002/pds.4695DOI Listing
November 2018
2 Reads

Cardiogenic Shock after Nifedipine Administration in a Pregnant Patient: A Case Report and Review of the Literature.

J Transl Int Med 2018 09 9;6(3):152-156. Epub 2018 Oct 9.

Department of Intensive Care Medicine, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

We present a case of a 21-year-old Caucasian woman at 27 weeks of pregnancy who was admitted to the obstetric department for pre-term labor. She received 10 mg of nifedipine 4 times in 1 h, according to the internal protocol. Shortly after, she brutally deteriorated with pulmonary edema and hypoxemia requiring transfer to the intensive care unit (ICU) for mechanical ventilation. Read More

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http://content.sciendo.com/view/journals/jtim/6/3/article-p1
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http://dx.doi.org/10.2478/jtim-2018-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231299PMC
September 2018
11 Reads

Obstetric anesthesia management of the patient with cardiac disease.

Int J Obstet Anesth 2018 Sep 27. Epub 2018 Sep 27.

Cardiovascular Division, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Cardiovascular disease is the leading cause of maternal mortality in much of the developed world. Risk stratification models can predict which patients are at greatest risk for maternal or fetal morbidity or mortality. Particular cardiac diseases hold significant risk of mortality during pregnancy including pulmonary hypertension, aortic aneurysm, left-ventricular outflow tract obstruction, and severe cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.ijoa.2018.09.011DOI Listing
September 2018
2 Reads

Successful low-dosage thrombolysis of massive pulmonary embolism in primigravida: A case report.

Medicine (Baltimore) 2018 Oct;97(43):e12985

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine.

Rational: Thrombolysis in primigravida with hemodynamic instability is controversial, especially treatment with low-dosage recombinant tissue plasminogen activator (rtPA), and related studies are extremely rare. Here, we report the case of a 26-year-old primigravida diagnosed with an acute massive pulmonary embolism (PE) that prompted initiation of thrombolysis with low-dose alteplase.

Patient Concerns: The patient was admitted to the Emergency Department with chief complaints of a sudden onset of extremely dyspnea, chest tightness, and confusion over a 6-hour period. Read More

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http://dx.doi.org/10.1097/MD.0000000000012985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221663PMC
October 2018
9 Reads

Maternal immunization downregulates offspring TCD4 regulatory cells (Tregs) thymic maturation without implications for allergy inhibition.

Scand J Immunol 2018 Dec 28;88(6):e12721. Epub 2018 Oct 28.

Division of Dermatology, Laboratory of Medical Investigation LIM 56, Medical School, University of Sao Paulo, Sao Paulo, Brazil.

The regulation of offspring allergy development mediated by maternal immunization was evidenced by several groups, and this mechanism seems to involve the induction of regulatory T cells (Tregs) on offspring. Here, we aimed to evaluate whether the effect of maternal immunization on offspring Tregs occurs as a result of peripheral or central modulation. Briefly, C57BL/6 female mice were immunized with OVA in Alum or Alum alone and boosted with OVA in saline or saline only after 10 and 20 days. Read More

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http://doi.wiley.com/10.1111/sji.12721
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http://dx.doi.org/10.1111/sji.12721DOI Listing
December 2018
10 Reads

Magnetic resonance imaging for evaluation of foetal multicystic dysplastic kidney.

Authors:
Hui Ji Su-Zhen Dong

Eur J Radiol 2018 Nov 24;108:128-132. Epub 2018 Sep 24.

Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. Electronic address:

We sought to evaluate the diagnostic value of foetal magnetic resonance imaging (MRI) for multicystic dysplastic kidney (MCDK) disease. We retrospectively identified 55 foetuses with MCDK diagnosed (51 unilateral; 4 bilateral) by foetal MRI. We analysed the anatomical findings by prenatal MRI and compared them with the prenatal ultrasound (US) and postnatal findings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183033
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http://dx.doi.org/10.1016/j.ejrad.2018.09.025DOI Listing
November 2018
7 Reads

Crisscross heart with situs invesus in pregnancy: A rare case report and literature review.

Echocardiography 2018 11;35(11):1885-1888

Shengjing Hospital of China Medical University, Shenyang, China.

Crisscross heart(CCH) is a rare congenital anomaly. CCH is always with rare complex congenital heart malformations, and for this reason it is difficult to diagnose. We present an asymptomatic 29-year-old pregant woman with history of cardiac murmur at 28 weeks of gestation. Read More

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http://doi.wiley.com/10.1111/echo.14155
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http://dx.doi.org/10.1111/echo.14155DOI Listing
November 2018
6 Reads

[Comparison of risk factors and short-term and long-term prognosis of pulmonary embolism between the Tibetan and Han people].

Zhonghua Yi Xue Za Zhi 2018 Oct;98(40):3249-3252

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.

To compare the differences of risk factors and prognosis of pulmonary embolism (PE) between the Tibetans and the Hans. Patients over 18 years old with confirmed PE and complete clinical data from West China Hospital of Sichuan University from January 2010 to January 2016 were prospectively enrolled and divided into Tibetan group and Han group. Clinical data were collected to compare risk factors and short-term prognosis between Han group and Tibetan group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.40.007DOI Listing
October 2018
1 Read

Moderate-intensity endurance-exercise training in patients with sickle-cell disease without severe chronic complications (EXDRE): an open-label randomised controlled trial.

Lancet Haematol 2018 Nov;5(11):e554-e562

Sickle-Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital-UPEC/Assistance Publique-Hôpitaux de Paris (APHP), Créteil, France; Department of Public Health, Henri-Mondor University Hospital-UPEC/Assistance Publique-Hôpitaux de Paris (APHP), Créteil, France. Electronic address:

Background: Exercise could be a triggering factor for vaso-occlusive crises in patients with sickle-cell disease. We aimed to investigate whether a patient-adapted training programme of moderate endurance exercise could be safe and beneficial for patients with sickle-cell disease.

Methods: We did a multicentre, prospective, open-label, randomised controlled trial at four university hospitals in France. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523026183016
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http://dx.doi.org/10.1016/S2352-3026(18)30163-7DOI Listing
November 2018
17 Reads

Pregnancy and pulmonary hypertension: An exploratory analysis of risk factors and outcomes.

Medicine (Baltimore) 2018 Nov;97(44):e13035

Department of Respiratory Medicine.

Pregnancy is usually contraindicated in patients with pulmonary hypertension (PH). Risk factors associated with the outcome of this rare disease have not been specifically explored before.Medical records were retrospectively reviewed to identify patients with coexisting PH and pregnancy or delivery at Peking Union Medical College Hospital between January 2009 and June 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000013035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221755PMC
November 2018
1 Read

Melatonin treatment in fetal and neonatal diseases.

Pathol Res Pract 2018 Dec 23;214(12):1940-1951. Epub 2018 Oct 23.

Discipline of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. Electronic address:

This literature review aims to address the main scientific findings on oxidative stress activity in different gestational disorders, as well as the function and application of melatonin in the treatment of fetal and neonatal changes. Oxidative stress has been associated with the etiopathogenesis of recurrent miscarriages, preeclampsia, intrauterine growth restriction, and stillbirth. Both, the exacerbated consumption of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, and the increased synthesis of reactive oxygen species, such as superoxide, peroxynitrite, and hydrogen peroxide, induce phospholipid peroxidation and endothelial dysfunction, impaired invasion and death of trophoblast cells, impaired decidualization, and remodeling of maternal spiral arteries. Read More

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http://dx.doi.org/10.1016/j.prp.2018.10.016DOI Listing
December 2018
1 Read

CT features of lung agenesis - a case series (6 cases).

BMC Med Imaging 2018 10 30;18(1):37. Epub 2018 Oct 30.

Department of Radiology, French Medical Institute for Mothers & Children (FMIC), behind Kabul Medical University, Jamal mina, P.O. Box: 472, Kabul, Afghanistan.

Back Ground: Lung agenesis is a rare congenital anomaly. The main etiology of the disease is unknown whereas genetic, iatrogenic and viral factors as well as vitamin A deficiency during early pregnancy may result in developmental failure of primitive lung bud causing unilateral pulmonary agenesis. Affected patients usually present with variable respiratory symptoms and recurrent chest infection at any age. Read More

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https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12880-018-0281-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208179PMC
October 2018
3 Reads
0.983 Impact Factor

Diagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study.

Ann Intern Med 2018 Dec 23;169(11):766-773. Epub 2018 Oct 23.

Université de Brest, Brest, France, and Ottawa Health Research Institute, Ottawa, Ontario, Canada (G.L.).

Background: Data on the optimal diagnostic management of pregnant women with suspected pulmonary embolism (PE) are limited, and guidelines provide inconsistent recommendations on use of diagnostic tests.

Objective: To prospectively validate a diagnostic strategy in pregnant women with suspected PE.

Design: Multicenter, multinational, prospective diagnostic management outcome study involving pretest clinical probability assessment, high-sensitivity D-dimer testing, bilateral lower limb compression ultrasonography (CUS), and computed tomography pulmonary angiography (CTPA). Read More

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http://annals.org/article.aspx?doi=10.7326/M18-1670
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http://dx.doi.org/10.7326/M18-1670DOI Listing
December 2018
11 Reads

Maternal sickle cell disease and twin pregnancy: a case series and review of the literature.

Hematology 2019 Dec 21;24(1):148-158. Epub 2018 Oct 21.

d Women's Health, St. Thomas' Hospital, King's Health Partners, Guy's and St Thomas' NHS Foundation Trust , London , UK.

Objectives: Maternal sickle cell disease (SCD) and multiple gestations are well known separately as causes of high-risk pregnancies, however, there is sparse information available on maternal and perinatal outcome when both conditions occur together. This case series describes the outcomes of women with maternal SCD and twin pregnancy in the largest single-center case series to date.

Methods: Retrospective identification of all twin pregnancies in maternal SCD patients between 2006 and 2016 at Guy's and St. Read More

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http://dx.doi.org/10.1080/10245332.2018.1535534DOI Listing
December 2019
2 Reads

[A case of systemic lupus erythematosus in pregnancy complicated by pulmonary hypertension].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Oct;50(5):928-931

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

To investigate the pathophysiology, screening, diagnosis and treatment of the systemic lupus erythematosus (SLE) in pregnancy complicated with pulmonary hypertension. Retrospective analysis was made of one case of SLE in pregnancy complicated with pulmonary hypertension in Peking University Third Hospital. Literature was reviewed to investigate the pathophysiology, screening, diagnosis and treatment of the SLE in pregnancy complicated with pulmonary hypertension. Read More

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October 2018
8 Reads

Tezacaftor/Ivacaftor (Symdeko) for cystic fibrosis.

Authors:

Med Lett Drugs Ther 2018 Oct;60(1558):174-176

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October 2018
6 Reads

Rapid Titration of Intravenous Treprostinil to Treat Severe Pulmonary Arterial Hypertension Postpartum: A Retrospective Observational Case Series Study.

Anesth Analg 2018 Oct 12. Epub 2018 Oct 12.

From the Departments of Surgical Intensive Care Medicine.

Background: Pulmonary hypertension during pregnancy carries high mortality rate. The relatively long-acting, specific pulmonary vasodilator treprostinil has been used to improve survival in these parturients. Slow uptitration is performed in most cases, and rapid titration has not been reported in the postpartum period. Read More

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http://Insights.ovid.com/crossref?an=00000539-900000000-9643
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http://dx.doi.org/10.1213/ANE.0000000000003827DOI Listing
October 2018
4 Reads
3.472 Impact Factor

[Risk factors for thromboembolic disease in young women-the role of hormones].

Rev Mal Respir 2018 Oct 11. Epub 2018 Oct 11.

EA 3878, CIC Inserm 1412, département de médecine interne et pneumologie, université de Bretagne Occidentale, centre hospitalo universitaire de Brest, 29609 Brest cedex, France. Electronic address:

Hormonal exposure in young women increases the risk of venous thromboembolic disease (VTE). Thrombophilia testing is often proposed in women of childbearing age before the initiation of contraception. However, the presence of a familial history of VTE has the potential to be more accurate than the presence of inherited thrombophilia. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.05.013DOI Listing
October 2018
1 Read

Pregnancy in adults with repaired/unrepaired atrial septal defect.

J Thorac Dis 2018 Sep;10(Suppl 24):S2945-S2952

Adult Congenital Heart Centre, Montreal Heart Institute, CHUS Ste-Justine, Université de Montréal, Montreal, Canada.

Atrial septal defect (ASD) is the most common form of congenital heart disease. Left-to-right shunting leads to right ventricular (RV) volume overload with excessive pulmonary blood flow. Complications include exercise intolerance, pulmonary vascular disease, RV dysfunction, paradoxical thromboemboli, and atrial arrhythmias. Read More

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http://jtd.amegroups.com/article/view/17362/18015
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http://dx.doi.org/10.21037/jtd.2017.10.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174140PMC
September 2018
2 Reads

The challenge of cardiomyopathies and heart failure in pregnancy.

Curr Opin Obstet Gynecol 2018 Dec;30(6):378-384

Heart Failure Unit, AORN Colli, Naples, Italy.

Purpose Of Review: To discuss the risk preexisting or new onset cardiomyopathy/heart failure (CMP/heart failure) in pregnant woman, and recent insights regarding their management and therapy.

Recent Findings: Recent data from the European Registry on Pregnancy and Heart disease of the European Society of Cardiology (ROPAC) suggest that, after an adequate prepregnancy evaluation in specialized centres, the vast majority of pregnancies are safe for both mother and foetus. A tailored approach is required according to cardiac phenotype (i. Read More

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http://Insights.ovid.com/crossref?an=00001703-900000000-9928
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http://dx.doi.org/10.1097/GCO.0000000000000496DOI Listing
December 2018
2 Reads

Venous Thromboembolism in Women Undergoing Assisted Reproductive Technologies: Data from the RIETE Registry.

Thromb Haemost 2018 Nov 8;118(11):1962-1968. Epub 2018 Oct 8.

Department of Internal Medicine, Hospital Universitario Germans Trias i Pujol de Badalona, Universidad Católica de Murcia, Barcelona, Spain.

Venous thromboembolism (VTE) during or after assisted reproductive technologies (ART) is predicted to rise due to the increased number of women undergoing this technique. We present data collected in the RIETE registry up to October 2016. Overall, 41 (0. Read More

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http://dx.doi.org/10.1055/s-0038-1673402DOI Listing
November 2018
7 Reads