26,937 results match your criteria Pulmonary Disease and Pregnancy


Fetal double outlet right ventricle without heterotaxy syndrome: diagnostic spectrum, associated extracardiac pathology and clinical outcomes.

Prenat Diagn 2021 Jun 12. Epub 2021 Jun 12.

Fetal & Neonatal Cardiology Program, Division of Pediatric Cardiology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To document the clinical spectrum and outcomes of fetal DORV without heterotaxy in a recent diagnostic era.

Methods: Prenatal cases of DORV consecutively diagnosed from 2007-2018 were retrospectively identified. Clinical records, including details regarding genetic testing and pre and postnatal imaging were reviewed. Read More

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Differences in coronavirus disease 2019 screening, diagnosis, and hospitalization rates among U.S. pregnant women with and without a substance use disorder.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Gynecology & Reproductive Sciences Magee-Womens Research Institute University of Pittsburgh Pittsburgh, Pennsylvania.

Objective: Pregnant women are at increased risk for severe morbidity and mortality due to respiratory infections like SARS-CoV-2 (COVID-19) during pregnancy. Those with substance use disorders (SUD) may be especially vulnerable due to high rates of smoked tobacco, cannabis and methamphetamine use which adversely affect pulmonary function. However, little is known about differential effects of COVID-19 on pregnant women with and without SUD. Read More

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Spontaneous pneumomediastinum associated with Covid-19 pneumonia in a pregnant woman.

Rev Soc Bras Med Trop 2021 2;54:e01852021. Epub 2021 Jun 2.

Ondokuz Mayis University, Faculty of Medicine, Obstetrics and Gynecology, Samsun, Turkey.

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COVID-19 and mental health of pregnant women in Ceará, Brazil.

Rev Saude Publica 2021 2;55:37. Epub 2021 Jun 2.

Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Saúde Coletiva. Fortaleza, CE, Brasil.

Objective: To assess the perceptions of pregnant women about COVID-19 and the prevalence of common mental disorders during the implemented social distancing period.

Methods: This was an observational, cross-sectional study using digital media, of pregnant women exposed to social distancing due to the COVID-19 pandemic, in Fortaleza, Ceará, Northeastern Brazil. Common mental disorders were estimated using the modified Self-Report Questionnaire-20 (SRQ-20) scale, and the feelings towards COVID-19 were assessed using the Fear of COVID-19 scale through telephone calls made in May 2020. Read More

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Pulmonary arterial hypertension in pregnancy-a systematic review of outcomes in the modern era.

Pulm Circ 2021 Apr-Jun;11(2):20458940211013671. Epub 2021 May 14.

Division of Cardiology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.

Pregnancy is hazardous with pulmonary arterial hypertension, but maternal mortality may have fallen in recent years. We sought to systematically evaluate pulmonary arterial hypertension and pregnancy-related outcomes in the last decade. We searched for articles describing outcomes in pregnancy cohorts published between 2008 and 2018. Read More

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Which ethical values underpin England's National Health Service reset of paediatric and maternity services following COVID-19: a rapid review.

BMJ Open 2021 06 8;11(6):e049214. Epub 2021 Jun 8.

Law and Philosophy, Faculty of Humanities and Social Sciences, University of Liverpool, Liverpool, UK.

Objective: To identify ethical values guiding decision making in resetting non-COVID-19 paediatric surgery and maternity services in the National Health Service (NHS).

Design: A rapid review of academic and grey literature sources from 29 April to 31 December 2020, covering non-urgent, non-COVID-19 healthcare. Sources were thematically synthesised against an adapted version of the UK Government's Pandemic Flu Ethical Framework to identify underpinning ethical principles. Read More

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Nosocomial SARS-CoV-2 transmission in a neonatal unit in Botswana: chronic overcrowding meets a novel pathogen.

BMJ Case Rep 2021 Jun 7;14(6). Epub 2021 Jun 7.

Department of Paediatric and Adolescent Health, University of Botswana, Gaborone, Botswana.

We describe a cluster of six SARS-CoV-2 infections occurring in a crowded neonatal unit in Botswana, including presumed transmission among mothers, postnatal mother-to-neonate transmission and three neonate-to-healthcare worker transmissions. The affected neonate, born at 25 weeks' gestation weighing 785 g, had a positive SARS-CoV-2 test at 3 weeks of age which coincided with new onset of hypoxaemia and worsening respiratory distress. Because no isolation facility could accommodate both patient and mother, they were separated for 10 days, during which time the patient was switched from breastmilk to formula. Read More

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A 19-Year-Old Pregnant Woman With Pulmonary Hypertension With Progressive Dyspnea.

Chest 2021 Jun;159(6):e371-e375

Department of Cardiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Case Presentation: A 19-year-old pregnant woman at week 32 of gestation was referred to our clinic with progressive shortness of breath for the further evaluation and treatment of high-risk pregnancy. Her complaints had been existing since her childhood. Two years prior to her admission, she had been diagnosed with heart failure with preserved ejection fraction due to cardiomyopathy and associated pulmonary hypertension. Read More

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Contemporary Outcomes in Tetralogy of Fallot With Absent Pulmonary Valve After Fetal Diagnosis.

J Am Heart Assoc 2021 Jun 8:e019713. Epub 2021 Jun 8.

Division of Cardiology Children's National HospitalDepartment of PediatricsGeorge Washington University School of Medicine and Health Sciences Washington DC.

Background Tetralogy of Fallot with absent pulmonary valve is associated with high mortality, but it remains difficult to predict outcomes prenatally. We aimed to identify risk factors for mortality in a large multicenter cohort. Methods and Results Fetal echocardiograms and clinical data from 19 centers over a 10-year period were collected. Read More

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Modified lung ultrasound scoring system to evaluate the feasibility of pregnant women with COVID-19 pneumonia.

J Matern Fetal Neonatal Med 2021 Jun 6:1-6. Epub 2021 Jun 6.

Department of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

Objective: To investigate whether physicians with short-term training can use a modified lung ultrasound scoring system for coronavirus disease 2019 (COVID-19) pneumonia to assess lung damage in pregnant women.

Methods: Sixteen consecutively hospitalized third-trimester pregnant women with pregnancy-induced hypertension, preeclampsia, rheumatoid arthritis or connective tissue disease were selected as the study subjects for the simulation of COVID-19 pneumonia. Two physicians (imaging and internal medicine) without ultrasonic experience performed lung examinations on pregnant women after six days of lung ultrasound training, and their consistency with examinations by the expert was assessed. Read More

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Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study.

Environ Int 2021 Jun 3;155:106673. Epub 2021 Jun 3.

Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States. Electronic address:

Prenatal arsenic exposure is associated with an increased risk of lung cancer along with multiple non-carcinogenic outcomes, including respiratory diseases in arsenic-contaminated areas. Limited epidemiologic data exist on whether in utero arsenic exposure influences lung development and subsequent respiratory health. We investigated the association between gestational arsenic exposure and childhood lung function in the New Hampshire Birth Cohort Study. Read More

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Intrapulmonary artery Doppler to predict mortality and morbidity in fetuses with mild and moderate left-sided congenital diaphragmatic hernia.

Ultrasound Obstet Gynecol 2021 Jun 5. Epub 2021 Jun 5.

Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu),, Institut Clínic de Ginecologia, Obstetricia i Neonatologia, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.

Objective: In fetuses with left-sided isolated congenital diaphragmatic hernia (LCDH), prenatal detection of severe pulmonary hypoplasia is relevant since fetal therapy can improve survival. Moderate and mild hypoplasia still carry a considerable mortality and morbidity risk, but there has been less interest in the accurate prediction of these. In this study on fetuses with moderate or mild CDH, we aimed to investigate: (1) the correlation between intra-pulmonary-artery Doppler (IPaD) findings and mortality, (2) whether adding these improves prediction of mortality based on lung size and liver herniation; and (3) whether the IPaD correlates with early neonatal morbidity. Read More

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Vertical transmission of SARS-CoV-2: A prospective cross-sectional study from a tertiary center.

J Med Virol 2021 Jun 3. Epub 2021 Jun 3.

Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.

The aim was to investigate the association of the delivery mode and vertical transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) through the samples of vaginal secretions, placenta, cord blood, or amniotic fluid as well as the neonatal outcomes. This cross-sectional study presents an analysis of prospectively gathered data collected at a single tertiary hospital. Sixty-three pregnant women with confirmed coronavirus disease 2019 (COVID-19) participated in the study. Read More

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Use of Electronic Medical Records to Estimate Changes in Pregnancy and Birth Rates During the COVID-19 Pandemic.

JAMA Netw Open 2021 06 1;4(6):e2111621. Epub 2021 Jun 1.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor.

Importance: The influence of the COVID-19 pandemic on fertility rates has been suggested in the lay press and anticipated based on documented decreases in fertility and pregnancy rates during previous major societal and economic shifts. Anticipatory planning for birth rates is important for health care systems and government agencies to accurately estimate size of economy and model working and/or aging populations.

Objective: To use projection modeling based on electronic health care records in a large US university medical center to estimate changes in pregnancy and birth rates prior to and after the COVID-19 pandemic societal lockdowns. Read More

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The Differences in Clinical Presentation, Management, and Prognosis of Laboratory-Confirmed COVID-19 between Pregnant and Non-Pregnant Women: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 05 24;18(11). Epub 2021 May 24.

Robinson Research Institute, University of Adelaide, Adelaide 5005, Australia.

Background: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people across the globe. Previous coronavirus outbreaks led to worsened symptoms amongst pregnant women, suggesting that pregnant women are at greater risk.

Objectives: Our aim is to investigate the differences in clinical presentation, management, and prognosis of COVID-19 infection in pregnant and non-pregnant women. Read More

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Is the First of the Two Born Saved? A Rare and Dramatic Case of Double Placental Damage from SARS-CoV-2.

Viruses 2021 05 26;13(6). Epub 2021 May 26.

Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.

The current coronavirus pandemic has affected, in a short time, various and different areas of medicine. Among these, the obstetric field has certainly been touched in full, and the knowledge of the mechanisms potentially responsible for placental damage from SARS-CoV-2 occupy a certain importance. Here we present here a rare case of dichorionic twins born at 30 weeks and 4 days of amenorrhea, one of whom died in the first few hours of life after placental damages potentially related to SARS-CoV-2. Read More

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Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy.

Int J Environ Res Public Health 2021 May 26;18(11). Epub 2021 May 26.

Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea.

There are reports that pregnant women infected with SARS-CoV-2 not only have increased morbidity but also increased complications and evidence of maternal and fetal vascular malperfusion on placental pathology. This was a retrospective study of pregnant women diagnosed with SARS-CoV-2 infection after March 2020. The results of reverse transcription polymerase chain reaction testing and IgM and IgG antibody testing of the amniotic fluid, cord blood, placenta, and maternal blood were confirmed at delivery. Read More

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Consequences of Early Separation of Maternal-Newborn Dyad in Neonates Born to SARS-CoV-2 Positive Mothers: An Observational Study.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Roma, Italy.

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues its spread all over the world, data on perinatal management of the maternal-infant dyad are urgent. We performed an observational study to describe the effects of the early separation of the maternal-infant dyad, in case of maternal SARS-CoV-2 infection. We reported the medical records for 37 neonates born to 37 SARS-CoV-2 positive mothers in a setting of separation of the dyad after birth. Read More

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Wellbeing of Breastfeeding Women in Australia and New Zealand during the COVID-19 Pandemic: A Cross-Sectional Study.

Nutrients 2021 May 27;13(6). Epub 2021 May 27.

School of Molecular Sciences, University of Western Australia, Perth, WA 6009, Australia.

During the COVID-19 pandemic, breastfeeding women have experienced restricted access to support, placing them at increased risk of mental health concerns and limited breastfeeding assistance. This study investigated the effect of the pandemic on feeding choices and maternal wellbeing amongst breastfeeding mothers living in Australian and New Zealand. We conducted a cross-sectional online survey that examined feeding methods, maternal mental wellbeing, worries, challenges, and positive experiences during the pandemic. Read More

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Pregnancy and COVID-19 Pandemic Perception in Malaysia: A Cross-Sectional Study.

Int J Environ Res Public Health 2021 May 27;18(11). Epub 2021 May 27.

Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Malaysia, Universiti Kebangsaan Malaysia Medical Center, Cheras 56000, Malaysia.

Pregnant women are susceptible to COVID-19 complications due to gestation-related physiological changes. We aimed to evaluate the level of maternal knowledge, perception, and practice during the pandemic. A cross-sectional study was conducted during the Malaysian Movement Control Order (MCO) between April and June 2020. Read More

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Breast Milk and COVID-19: From Conventional Data to "Omics" Technologies to Investigate Changes Occurring in SARS-CoV-2 Positive Mothers.

Int J Environ Res Public Health 2021 May 25;18(11). Epub 2021 May 25.

Neonatal Intensive Care Unit, Department of Surgical Sciences, AOU and University of Cagliari, SS 554 km 4500, 09042 Monserrato, Italy.

In this context of COVID-19 pandemic, great interest has been aroused by the potential maternal transmission of SARS-CoV-2 by transplacental route, during delivery, and, subsequently, through breastfeeding. Some open questions still remain, especially regarding the possibility of finding viable SARS-CoV-2 in breast milk (BM), although this is not considered a worrying route of transmission. However, in BM, it was pointed out the presence of antibodies against SARS-CoV-2 and other bioactive components that could protect the infant from infection. Read More

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SARS-CoV-2 Infection Susceptibility of Pregnant Patients at Term Regarding ABO and Rh Blood Groups: A Cohort Study.

Medicina (Kaunas) 2021 May 14;57(5). Epub 2021 May 14.

Department of Obstetrics and Gynecology, Elena Doamna Obstetrics and Gynecology University Hospital, 700398 Iasi, Romania.

: The susceptibility of pregnant patients at term to SARS-CoV-2 infection regarding the ABO and Rh blood group polymorphism was analyzed in this study. In this prospective study, 457 patients admitted for delivery at term in our hospital, between 1 April 2020 and 31 December 2020 were studied. There were 46 positive and 411 SARS-CoV-2 negative patients. Read More

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A New Multiplatform Model for Outpatient Prenatal and Postpartum Care in a Cohort of COVID-19-Affected Obstetric Patients.

Int J Environ Res Public Health 2021 05 12;18(10). Epub 2021 May 12.

Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.

Spain was one of the epicenters of the first wave of the COVID-19 pandemic. We describe in this article the design and results of a new telephone-and-telematic multiplatform model of systematic prenatal and postpartum follow-up for COVID-19-affected women implemented in a tertiary reference hospital in Madrid. We included patients with RT-PCR-confirmed COVID-19 during pregnancy or delivery from 10 March 2020 to 15 December 2020. Read More

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Influence of Socioeconomic Status on SARS-CoV-2 Infection in Spanish Pregnant Women. The MOACC-19 Cohort.

Int J Environ Res Public Health 2021 05 12;18(10). Epub 2021 May 12.

Faculty of Medicine, Universidad de Cantabria, 39011 Santander, Spain.

Little is known on socio-economic factors associated with SARS-CoV-2 infection in pregnant women. Here, we analyze the relationship between educational, occupational, and housing variables with SARS-CoV-2 infection in a cohort of 988 pregnant women in Spain. Pregnant women were recruited at the University Hospital Marques de Valdecilla, Santander, Spain, among those delivering from 23 March 2020 onwards or consulting for their 12th week of pregnancy from 26 May 2020 onwards. Read More

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Intimate Partners Violence against Women during a COVID-19 Lockdown Period: Results of an Online Survey in 7 Provinces of the Democratic Republic of Congo.

Int J Environ Res Public Health 2021 05 12;18(10). Epub 2021 May 12.

Global Health Institute, University of Antwerp, 2000 Antwerp, Belgium.

Intimate Partners' Violence (IPV) is a public health problem with long-lasting mental and physical health consequences for victims and their families. As evidence has been increasing that COVID-19 lockdown measures may exacerbate IPV, our study sought to describe the magnitude of IPV in women and identify associated determinants. An online survey was conducted in the Democratic Republic of Congo (DRC) from 24 August to 8 September 2020. Read More

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Outpatient Telehealth Implementation in the United States during the COVID-19 Global Pandemic: A Systematic Review.

Medicina (Kaunas) 2021 May 9;57(5). Epub 2021 May 9.

The School of Community and Rural Health, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.

Ambulatory (outpatient) health care organizations continue to respond to the COVID-19 global pandemic using an array of initiatives to provide a continuity of care and related patient outcomes. Telehealth has quickly become an advantageous tool in assisting outpatient providers in this challenge, which has also come with an adaptation of U.S. Read More

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Air Pollution, Neonatal Immune Responses, and Potential Joint Effects of Maternal Depression.

Int J Environ Res Public Health 2021 May 11;18(10). Epub 2021 May 11.

Department of Social and Behavioral Sciences, The Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Prenatal maternal exposure to air pollution may cause adverse health effects in offspring, potentially through altered immune responses. Maternal psychosocial distress can also alter immune function and may increase gestational vulnerability to air pollution exposure. We investigated whether prenatal exposure to air pollution is associated with altered immune responses in cord blood mononuclear cells (CBMCs) and potential modification by maternal depression in 463 women recruited in early pregnancy (1999-2001) into the Project Viva longitudinal cohort. Read More

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Universal screening for SARS-CoV-2 in pregnant women using a combination of antigen and RT-PCR testing.

Infez Med 2021 Jun;29(2):294-296

Department of Infectious Disease, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Ponekkara, Kochi, India.

Not available. Read More

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The role of nebivolol in the management of hypertensive patients: from pharmacological profile to treatment guidelines.

Authors:
Claudio Ferri

Future Cardiol 2021 Jun 1. Epub 2021 Jun 1.

Department of Life, Health & Environmental Sciences, University of L'Aquila, San Salvatore Hospital, L'Aquila, Italy.

According to the most recent international guidelines, β-blockers maintain a central role in the management of hypertension, being recommended at any treatment step when there is a specific indication, such as heart failure, angina, postacute myocardial infarction, atrial fibrillation or pregnancy. However, β-blockers are not a homogeneous class: individual molecules differ in terms of pharmacological and clinical profile and are therefore suitable for different patient subtypes. In particular nebivolol, a third generation β-selective β-blocker with vasodilating properties, neutral metabolic effects and good tolerability, proved to have advantages over other β-blockers, which makes the drug suitable in a wide variety of hypertensive patients with or without comorbidities. Read More

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