22,871 results match your criteria Pulmonary Disease and Pregnancy


Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism.

N Engl J Med 2019 Mar;380(12):1139-1149

From the Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden (L.M.P., T.H., F.A.K., M.V.H.), the Department of Internal Medicine, Haga Teaching Hospital (L.M.P., A.T.A.M.), and the Department of Internal Medicine, Haaglanden Medical Center (H.M.A.H.), the Department of Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam (I.M.B., S.M.), the Department of Internal Medicine, Flevo Hospital, Almere (I.M.B., M.W.), the Department of Internal Medicine, Gelre Hospital, Apeldoorn (T.B.), the Department of Pulmonology, Groene Hart Hospital, Gouda (Y.P.A.D.), the Department of Internal Medicine, Red Cross Hospital, Beverwijk (L.M.F.), the Department of Hematology, Erasmus University Medical Center, Rotterdam (M.J.H.A.K.), and the Department of Internal Medicine, University Medical Center Utrecht, Utrecht (M.N.), all of which are part of the Dutch Thrombosis Network (DTN) - all in the Netherlands; the Department of Internal Medicine and Chest Diseases, Brest Hospital Center, Groupe d'Etude de Thrombose de Bretagne Occidentale, University of Brest, EA 3878, CIC-INSERM 1412, University of Brest, Brest (C.T., F.C.), Service de médecine vasculaire et thérapeutique, Centre Hospitalier Universitaire (CHU) Saint Etienne, INSERM CIC-1408, INSERM Unité 1059, Equipe Dysfonction Vasculaire et Hémostase, Université Jean-Monnet, Saint Etienne (L.B.), the Department of Vascular Medicine, Sainte Musse Hospital, Toulon (A.E.), the Emergency Department, CHU Grenoble-Alpes, Hypoxy-Physiopathology laboratory HP2 INSERM 1042, Grenoble (M.M.), the Emergency Department, CHU d'Angers, UFR Santé, Université d'Angers, Institut Mitovasc, UMR CNRS 6015 UMR INSERM 1083, Angers (P.-M.R.), the Department of Pulmonary Disease and Intensive Care Unit, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Faculté de Médecine, Université Sorbonne Paris Cité, INSERM UMR S 1140, Paris (O.S.), and the Emergency Department, CHU de Clermont-Ferrand, Clermont-Ferrand (J.S.), all of which are part of the French Clinical Research Infrastructure Network-Investigation Network on Venous Thrombo-Embolism (F-CRIN INNOVTE Network, Saint Etienne) - all in France; and the School of Medicine, University College Dublin, and the Department of Haematology, Rotunda Hospital Dublin, INViTE Network, Dublin (F.N.A.).

Background: Pulmonary embolism is one of the leading causes of maternal death in the Western world. Because of the low specificity and sensitivity of the d-dimer test, all pregnant women with suspected pulmonary embolism undergo computed tomographic (CT) pulmonary angiography or ventilation-perfusion scanning, both of which involve radiation exposure to the mother and fetus. Whether a pregnancy-adapted algorithm could be used to safely avoid diagnostic imaging in pregnant women with suspected pulmonary embolism is unknown. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1813865
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http://dx.doi.org/10.1056/NEJMoa1813865DOI Listing
March 2019
1 Read

Use of benzodiazepine medications during pregnancy and potential risk for birth defects, National Birth Defects Prevention Study, 1997-2011.

Birth Defects Res 2019 Mar 19. Epub 2019 Mar 19.

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Benzodiazepine medications can be used to treat anxiety, a condition affecting 15% of women of childbearing age in the United States. Studies have shown conflicting results for the association between benzodiazepine use during pregnancy and birth defects.

Methods: We analyzed 1997-2011 data from the National Birth Defects Prevention Study, a multisite, population-based case-control study. Read More

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http://dx.doi.org/10.1002/bdr2.1497DOI Listing
March 2019
1 Read

High risk twin pregnancy complicated with severe rachiterata and huge dorsal mass suffering from refractory infection: A case report.

Medicine (Baltimore) 2019 Mar;98(11):e14462

Department of Obstetrics & Gynaecology, West China Second Hospital.

Rationale: Severe rachiterata is rarely described as a complication of pregnancy, and it was assumed as a contraindication to pregnancy. We first report a case of severe spinal deformity associated both with scoliosis and kyphosis in pregnancy.

Patient Concerns: A 38-year-old pregnant woman [28+1 weeks of twin pregnancy, gravida 3, para 2 (G3P2)] was admitted to the emergency department with complaints of persistent productive cough, with increased expectoration, dyspnea, dizziness, fatigue, and irregular abdominal pain. Read More

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http://dx.doi.org/10.1097/MD.0000000000014462DOI Listing

Outcome of pregnancies in women with Pulmonary Hypertension: A Single Centre Experience from South India.

BJOG 2019 Mar 14. Epub 2019 Mar 14.

Anaesthesiology& Critical Care, Jawaharlal Institute of Post-graduate Medical Education & Research (JIPMER), Puducherry, India, 605006.

Objective: To study maternal complications and pregnancy outcome in women with pulmonary hypertension, attending a tertiary centre in south India.

Study Design: Retrospective Observational study.

Setting: Tertiary centre in south India. Read More

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http://dx.doi.org/10.1111/1471-0528.15681DOI Listing
March 2019
1 Read

Revefenacin (Yupelri) for COPD.

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Med Lett Drugs Ther 2019 Jan;61(1564):14-15

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January 2019

Maternal and Perinatal Outcomes in Pregnant Women with Cystic Fibrosis.

Rev Bras Ginecol Obstet 2019 Mar 7. Epub 2019 Mar 7.

Faculty of Medicine, Division of Obstetrics, Department of Obstetrics and Gynecology, Hospital das Clínicas da Universidade de São Paulo, SP, Brazil.

Objectives:  To assess the perinatal and maternal outcomes of pregnant women with cystic fibrosis (CF) and severe lung impairment.

Methods:  This was a series of cases aiming to review the maternal and fetal outcomes in cases of singleton pregnant women with a diagnosis of CF. We have included all of the cases of singleton pregnancy in patients with CF who were followed-up at the obstetrics department of the Medical School of the Universidade de São Paulo, between 2003 and 2016. Read More

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http://dx.doi.org/10.1055/s-0039-1678613DOI Listing
March 2019
1 Read

Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide.

World J Clin Oncol 2019 Feb;10(2):28-37

Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College London, London W6 8RF, United Kingdom.

Gestational trophoblastic neoplasia (GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma (CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor (PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic cases. The diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics (FIGO) 2000 criteria: four or more plateaued human chorionic gonadotropin (hCG) concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. Read More

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http://dx.doi.org/10.5306/wjco.v10.i2.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390119PMC
February 2019
2 Reads

Obstetrical and perinatal outcome in pregnant women with extrapulmonary tuberculosis.

Indian J Tuberc 2019 Jan 10;66(1):158-162. Epub 2018 Nov 10.

Department of Obstetrics and Gynecology, AIIMS, New Delhi, India.

Tuberculosis (TB) is a major health problem and a leading cause of illness and death from infectious disease. Tuberculosis in pregnancy has been associated with increased risks of prematurity and small for gestational age (SGA)infants.The present study is aimed to examine obstetrical and perinatal outcomes among women who had extra-pulmonary tuberculosis. Read More

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http://dx.doi.org/10.1016/j.ijtb.2018.10.010DOI Listing
January 2019
1 Read

Interprofessional provider educational needs and preferences regarding the provision of sexual and reproductive health care in cystic fibrosis.

J Cyst Fibros 2019 Feb 19. Epub 2019 Feb 19.

Division of Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States of America.

Background: Sexual and reproductive health (SRH) is an important disease-specific concern for adolescent and young adult (AYA) women that is not consistently addressed in cystic fibrosis (CF) centers. This study identifies educational needs and preferences of interprofessional CF providers regarding SRH in AYA women with CF.

Methods: Interprofessional CF providers participated in an anonymous survey regarding general and CF-specific SRH knowledge and skills, factors for optimizing SRH care, and preferred approaches for SRH training. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.01.015DOI Listing
February 2019
1 Read

Requirement for etoposide in the treatment of pregnancy related hemophagocytic lymphohistiocytosis: a multicenter retrospective study.

Orphanet J Rare Dis 2019 02 18;14(1):50. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, China.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare severe clinical syndrome. HLH manifesting during pregnancy has been paid much attention in recent years. Despite the specificity of pregnancy-related HLH, there has not been any consensus regarding its treatment. Read More

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http://dx.doi.org/10.1186/s13023-019-1033-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380007PMC
February 2019
1 Read

Maternal and Neonatal Complications of Pregnant Women with Mitral Stenosis.

Isr Med Assoc J 2019 Feb;21(2):88-93

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.

Background: Rheumatic mitral stenosis (MS) is a relatively rare diagnosis in the developed countries and its treatment during pregnancy is challenging due to hemodynamic changes. With the demographic changes due to recent waves of immigration an increase in the prevalence of rheumatic heart disease is expected.

Objectives: To evaluate maternal and neonatal complications in patients with mitral stenosis. Read More

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February 2019
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Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats.

Reprod Toxicol 2019 Feb 13;85:34-41. Epub 2019 Feb 13.

Department of pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China. Electronic address:

Hepatic and pulmonary toxicity in fetal rats induced by pyrrolizidine alkaloids (PAs) was investigated. Retrorsine (RTS) or monocrotaline (MCT) was intragastrically administered during pregnancy. The reduction of body and tail lengths was consistent with body weight loss in PA-exposed fetuses, and pathological lesions in liver and lung were observed only in fetuses. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.006DOI Listing
February 2019
2 Reads

High-risk pregnancy in a patient with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) with temporary shunt inversion and deoxygenation.

Pulm Circ 2019 Apr-Jun;9(2):2045894019835649

2 Center for Grown-ups with Congenital Heart Disease (GUCH), Department III of Internal Medicine, Heart Center, University Hospital of Cologne, Cologne, Germany.

Atrial septal defect (ASD) is one of the most frequent congenital heart diseases (CHD). Up to 10% of adults with an ASD develop pulmonary arterial hypertension (PAH, PAH-CHD) in their lifetime. Despite improved therapy options, gravidity remains a substantial risk for both maternal and neonatal mortality in PAH-CHD patients. Read More

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http://dx.doi.org/10.1177/2045894019835649DOI Listing
February 2019
1 Read

Inflammatory Syndrome as the Initial Manifestation of Retroperitoneal Tuberculosis in a Pregnant Woman.

Eur J Case Rep Intern Med 2018 26;5(7):000865. Epub 2018 Jul 26.

Division of Pulmonary Diseases, Department of Internal Medicine Specialties, University Hospitals of Geneva, Switzerland.

A 20-year-old asylum seeker presented with vomiting and left thigh pain, with a biological inflammatory syndrome. Pregnancy was diagnosed. Investigations revealed a pseudo-cystic, 20-cm-long retroperitoneal abscess, biopsy of which confirmed the diagnosis of tuberculosis. Read More

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http://dx.doi.org/10.12890/2018_000865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346775PMC
July 2018
1 Read

Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases.

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.

Background: Allergies are a serious public health issue, and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- and post-natal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). Read More

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http://doi.wiley.com/10.1111/pai.13039
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http://dx.doi.org/10.1111/pai.13039DOI Listing
February 2019
13 Reads

Simultaneous targeting of linked loci in mouse embryos using base editing.

Sci Rep 2019 Feb 7;9(1):1662. Epub 2019 Feb 7.

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, 20892, USA.

A particular challenge in genome engineering has been the simultaneous introduction of mutations into linked (located on the same chromosome) loci. Although CRISPR/Cas9 has been widely used to mutate individual sites, its application in simultaneously targeting of linked loci is limited as multiple nearby double-stranded DNA breaks created by Cas9 routinely result in the deletion of sequences between the cleavage sites. Base editing is a newer form of genome editing that directly converts C∙G-to-T∙A, or A∙T-to-G∙C, base pairs without introducing double-stranded breaks, thus opening the possibility to generate linked mutations without disrupting the entire locus. Read More

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http://www.nature.com/articles/s41598-018-33533-5
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http://dx.doi.org/10.1038/s41598-018-33533-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367434PMC
February 2019
8 Reads
5.078 Impact Factor

Time and age trends in smoking cessation in Europe.

PLoS One 2019 7;14(2):e0211976. Epub 2019 Feb 7.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

Background: Smoking is the main risk factor for most of the leading causes of death. Cessation is the single most important step that smokers can take to improve their health. With the aim of informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation in Europe between 1980 and 2010. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211976PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366773PMC
February 2019
2 Reads

Accuracy of risk prediction scores in pregnant women with congenital heart disease.

Congenit Heart Dis 2019 Feb 6. Epub 2019 Feb 6.

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine Philadelphia, Pennsylvania.

Objective: To assess performance of risk stratification schemes in predicting adverse cardiac outcomes in pregnant women with congenital heart disease (CHD) and to compare these schemes to clinical factors alone.

Design: Single-center retrospective study.

Setting: Tertiary care academic hospital. Read More

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http://dx.doi.org/10.1111/chd.12750DOI Listing
February 2019
3 Reads

Pregnancy still contraindicated in pulmonary arterial hypertension related to congenital heart disease: True or false?

Eur J Prev Cardiol 2019 Feb 4:2047487318825347. Epub 2019 Feb 4.

Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.

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http://dx.doi.org/10.1177/2047487318825347DOI Listing
February 2019
2 Reads

IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age.

Front Immunol 2018 18;9:3166. Epub 2019 Jan 18.

Department of Pediatrics, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.

Preterm infants acquire reduced amounts of Immunoglobulin G (IgG) via trans-placental transfer as compared to term infants which might explain their high susceptibility for infections. The reduced amount of IgG antibodies also results in a lower amount of anti-inflammatory Fc N-galactosylated and -sialylated IgG antibodies. This reduction or, even more, a qualitative shift in the type of IgG Fc glycosylation might contribute to the increased risk for sustained inflammatory diseases in preterm infants. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346593PMC
January 2019
2 Reads

Extrauterine epithelioid trophoblastic tumors presenting as lung mass: A case report and literature review.

Medicine (Baltimore) 2019 Feb;98(5):e14010

Department of Obstetrics and Gynecology.

Rationale: Extrauterine epithelioid trophoblastic tumors (ETT) is a rare variant of gestational trophoblastic neoplasms. Here we aim to learn more clinical and pathological characteristics of ETT patient with an isolated pulmonary mass without uterine lesions, through a rare case of extra-uterine ETT and 7 cases published in English periodicals literature.

Patient Concerns: A 31-year-old Chinese woman, presented with low-level elevation of serum human chorionic gonadotropin (HCG) for more than 2 years without abnormal symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000014010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380824PMC
February 2019
1 Read

Impact of influenza on hospitalization rates in children with a range of chronic lung diseases.

Influenza Other Respir Viruses 2019 Jan 30. Epub 2019 Jan 30.

Faculty of Medicine, Discipline of Pediatrics, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.

Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited.

Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Read More

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http://doi.wiley.com/10.1111/irv.12633
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http://dx.doi.org/10.1111/irv.12633DOI Listing
January 2019
9 Reads

Mood and quality of life changes in pregnancy and postpartum and the effect of a behavioral intervention targeting excess gestational weight gain in women with overweight and obesity: a parallel-arm randomized controlled pilot trial.

BMC Pregnancy Childbirth 2019 Jan 29;19(1):50. Epub 2019 Jan 29.

Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

Background: Intensive lifestyle interventions in pregnancy have shown success in limiting gestational weight gain, but the effects on mood and quality of life in pregnancy and postpartum are less known. The purpose was to quantify changes in mental and physical quality of life and depressive symptoms across pregnancy and the postpartum period, to determine the association between gestational weight gain and change in mood and quality of life, and to assess the effect of a behavioral intervention targeting excess gestational weight gain on these outcomes.

Methods: A three group parallel-arm randomized controlled pilot trial of 54 pregnant women who were overweight or obese was conducted to test whether the SmartMoms® intervention decreased the proportion of women with excess gestational weight gain. Read More

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http://dx.doi.org/10.1186/s12884-019-2196-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352352PMC
January 2019
1 Read

Invasive Pulmonary Adenocarcinoma with Lepidic Growth Pattern in a Pregnant Patient.

Case Rep Oncol 2018 Sep-Dec;11(3):822-834. Epub 2018 Dec 11.

University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, The Netherlands.

Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. Read More

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http://dx.doi.org/10.1159/000495460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341323PMC
December 2018
8 Reads

Dupilumab (Dupixent) for asthma.

Authors:

Med Lett Drugs Ther 2019 Jan;61(1563):6-8

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January 2019
2 Reads

Intake of sucrose-sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in offspring: a Norwegian pregnancy cohort study.

Eur J Epidemiol 2019 Jan 19. Epub 2019 Jan 19.

Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.

Studies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened soft beverages during pregnancy and risk of CHD. Prospective cohort data with 88,514 pregnant women participating in the Norwegian Mother and Child Cohort Study was linked with information on infant CHD diagnoses from national health registers and the Cardiovascular Diseases in Norway Project. Read More

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http://link.springer.com/10.1007/s10654-019-00480-y
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http://dx.doi.org/10.1007/s10654-019-00480-yDOI Listing
January 2019
15 Reads

Outcomes of self-induced late pregnancy termination in women presenting to a tertiary hospital in the Eastern Cape Province, South Africa.

S Afr Med J 2018 Oct 26;108(11):965-971. Epub 2018 Oct 26.

Walter Sisulu University and Eastern Cape Department of Health, East London, South Africa.

Background: Little is known about the outcomes of self-induced pregnancy termination after 24 weeks' gestation, as previous studies have concentrated on outcomes before 24 weeks.

Objectives: To investigate the gestational age, misoprostol dosage, source of information on misoprostol, reasons for termination and outcomes of self-induced pregnancy termination after 24 weeks' gestation.

Methods: A quantitative, retrospective case series observational research design was utilised. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v108i11.12979DOI Listing
October 2018
4 Reads

Proximal, Distal, and Contralateral Effects of Blood Flow Restriction Training on the Lower Extremities: A Randomized Controlled Trial.

Sports Health 2019 Mar/Apr;11(2):149-156. Epub 2019 Jan 14.

Kerlan Jobe Institute, Los Angeles, California.

Background:: Blood flow restriction (BFR) training involves low-weight exercises performed under vascular occlusion via an inflatable cuff. For patients who cannot tolerate high-load exercises, BFR training reportedly provides the benefits of high-load regimens, with the advantage of less tissue and joint stress.

Hypothesis:: Low-load BFR training is safe and efficacious for strengthening muscle groups proximal, distal, and contralateral to tourniquet placement in the lower extremities. Read More

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http://dx.doi.org/10.1177/1941738118821929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391554PMC
January 2019
1 Read

An Versus Toxicogenomic Investigation of Prenatal Exposures to Tobacco Smoke.

Appl In Vitro Toxicol 2018 Dec 18;4(4):379-388. Epub 2017 May 18.

School of Biosciences, Cardiff University, Museum Avenue, Cardiff, United Kingdom.

Approximately 1 million women smoke during pregnancy despite evidence demonstrating serious juvenile and/or adult diseases being linked to early-life exposure to cigarette smoke. Susceptibility could be determined by factors in previous generations, that is, prenatal or "maternal" exposures to toxins. Prenatal exposure to airborne pollutants such as mainstream cigarette smoke has been shown to induce early-life insults (i. Read More

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http://dx.doi.org/10.1089/aivt.2016.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326191PMC
December 2018
1 Read

Associated Factors and Outcome of Babies Born Through Meconium Stained Amniotic Fluid.

Kathmandu Univ Med J (KUMJ) 2018 Jan.-Mar;16(61):65-68

Department of Community Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.

Background Neonates born through meconium stained amniotic fluid (MSAF) are associated with significant morbidity and mortality. Objective To study the incidence, associated factors and outcome of meconium stained amniotic fluid babies born in Dhulikhel hospital. Method Prospective, cross-sectional study conducted in Obstetric ward and Neonatal Intensive Care Unit (NICU) from 15 December 2015 to 15 December 2016. Read More

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February 2019
13 Reads

Three cases of multi-generational Gaucher disease and colon cancer from an Ashkenazi Jewish family: A lesson for cascade screening.

Mol Genet Metab Rep 2019 Mar 4;18:19-21. Epub 2019 Jan 4.

Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Gaucher disease (GD) is one of the commonest lysosomal storage diseases that is inherited in an autosomal recessive manner and affects 1 in 50,000 to 100,000 people in the general population. The frequency is much higher (1 in 500 to 1000) in people of Ashkenazi Jewish heritage due to a founder effect. GD is caused by decreased or absent activity of β-glucosidase with subsequent accumulation of the substrate glucosylceramide in macrophages due to genetic alterations in the gene. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321950PMC
March 2019
8 Reads

Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.

Can J Public Health 2019 Apr 7;110(2):149-158. Epub 2019 Jan 7.

Air Quality Research Division, Environment and Climate Change Canada, 4905 Dufferin St, 4th Floor, Office 4S310, Toronto, ON, M3H 5T4, Canada.

Objectives: To estimate the proportion of the Canadian population that is more susceptible to adverse effects of ozone (O) and fine particle (PM) air pollution exposure and how this varies by health region alongside ambient concentrations of O and PM.

Methods: Using data from the census, the Canadian Community Health Survey, vital statistics and published literature, we generated cross-sectional estimates for 2014 of the proportions of the Canadian population considered more susceptible due to age, chronic disease, pregnancy, outdoor work, socio-economic status, and diet. We also estimated 2010-2012 average concentrations of O and PM. Read More

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http://link.springer.com/10.17269/s41997-018-0169-8
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http://dx.doi.org/10.17269/s41997-018-0169-8DOI Listing
April 2019
10 Reads

Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia.

Ital J Pediatr 2019 Jan 7;45(1). Epub 2019 Jan 7.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Background: Prematurity accounts about 1 million neonatal deaths worldwide and the second causes of both neonatal and under five-child mortality. Neonatal mortality accounts for 43% of under-five child mortality in Ethiopia. From this preterm is the second leading cause of death and is steadily increased in low-income countries. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
Publisher Site
http://dx.doi.org/10.1186/s13052-018-0597-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322326PMC
January 2019
4 Reads
1.236 Impact Factor

Potential nutraceutical and food additive properties and risks of coffee: a comprehensive overview.

Crit Rev Food Sci Nutr 2019 Jan 7:1-27. Epub 2019 Jan 7.

a Department of Animal Nutrition, College of Animal Sciences and Technology , Northwest A & F University , Yangling , Shaanxi Province , P.R. China.

Coffee is a composite mixture of more than a thousand diverse phytochemicals like alkaloids, phenolic compounds, vitamins, carbohydrates, lipids, minerals and nitrogenous compounds. Coffee has multifunctional properties as a food additive and nutraceutical. As a nutraceutical, coffee has anti-inflammatory, anti-oxidant, antidyslipidemic, anti-obesity, type-2 diabetes mellitus (DM), and cardiovascular diseases (CVD), which can serve for the treatment and prevention of metabolic syndrome and associated disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408398.2018.1
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http://dx.doi.org/10.1080/10408398.2018.1489368DOI Listing
January 2019
6 Reads
5.176 Impact Factor

Vitamin D and childhood asthma: causation and contribution to disease activity.

Curr Opin Allergy Clin Immunol 2019 Apr;19(2):126-131

Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York, USA.

Purpose Of Review: To review the literature of the past 18 months (April 2017 through September, 2018) relating to vitamin D and childhood asthma.

Recent Findings: A combined analysis of two clinical trials of maternal vitamin D supplementation trials showed a significant protective effect of vitamin D supplementation trials in the primary prevention of asthma and recurrent wheeze up to age 3 years. Secondary analyses from these trials have also suggested that initial maternal vitamin D status could affect the response to supplementation during pregnancy, with the biggest protective effect in children born to mothers with initial 25hydroxyvitamin D (25OHD) levels of at least 30 ng/ml. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395509PMC
April 2019
9 Reads

What is safe enough - asthma in pregnancy - a review of current literature and recommendations.

Asthma Res Pract 2018 27;4:11. Epub 2018 Dec 27.

1Faculty of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia.

Background: Although asthma is one of the most serious diseases causing complications during pregnancy, half of the women discontinue therapy thus diminishing the control of the disease, mostly due to the inadequate education and fear of adverse events. Sadly, this is sometimes encouraged by insufficiently educated physicians. Since the incidence and the prevalence of asthma is increasing, it is important to arouse the importance of proper asthma therapy during pregnancy. Read More

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http://dx.doi.org/10.1186/s40733-018-0046-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307305PMC
December 2018
2 Reads

[Clinical characteristics and risk factors in pregnancy with severe community-acquired pneumonia].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):842-848

Department of Intensive Care Unit, Foshan Woman and Children Hospital, Southern Medical University, Foshan 528000, China.

To analyze clinical characteristics of severe community-acquired pneumonia during pregnancy and its outcomes, and to explore the relevant risk factors. From September 2012 to September 2017, 324 398 pregnancies admitted in 7 tertiary hospitals were included. Clinical data of 33 cases of pregnancies with severe community-acquired pneumonia (severe pneumonia group) and 214 cases of pregnancies with common community-acquired pneumonia (control group) were reviewed retrospectively, including the clinical information, manifestations, laboratory examinations and pregnancy outcomes. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.008DOI Listing
December 2018
5 Reads

Beating the Odds: A Full-Term Delivery After Liver Transplantation of a Pregnant Hyperthyroid Patient at 19 Weeks' Gestation for Propylthiouracil-Induced Acute Liver Failure.

Transplant Proc 2018 Dec 30;50(10):3995-3999. Epub 2018 Jun 30.

Division of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia; Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia; Division of Gastroenterology and Hepatology, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

Liver transplantation (LT) for acute liver failure is an uncommon occurrence in the setting of pregnancy given the risk of fetal demise, and rarely is it undertaken with a viable fetus. Maternal hyperthyroidism increases fetal risk in the setting of LT, particularly in the setting of thyrotoxicosis. We report the first case of propylthiouracil-induced acute liver failure in a hyperthyroid patient in her second trimester resulting in LT. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.06.046DOI Listing
December 2018
1 Read

Neonatal and Maternal Outcomes in Pregnant Women With Cardiac Disease.

J Am Heart Assoc 2018 Nov;7(21):e009395

1 Division of Cardiovascular Medicine Department of Medicine State University of New York Stony Brook University Medical Center Stony Brook NY.

Background Pregnant women with underlying heart disease ( HD ) are at increased risk for adverse maternal, obstetric, and neonatal outcomes. Methods and Results Inpatient maternal delivery admissions and linked neonatal stays for women with cardiomyopathy, adult congenital HD, pulmonary hypertension ( PH ), and valvular HD were explored utilizing the Statewide Planning and Research Cooperative System (New York), January 1, 2000, through December 31, 2014, with the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). Maternal major adverse cardiac events, neonatal adverse clinical events ( NACE ), and obstetric complications were recorded. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009395
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http://dx.doi.org/10.1161/JAHA.118.009395DOI Listing
November 2018
2 Reads
2.882 Impact Factor

Prenatally Diagnosed Ventricular Inversion, Restrictive Ventricular Septal Defect, Pulmonary Stenosis, Hypertensive Left Ventricle and Double Outlet Right Ventricle: Case Report and Literature Review.

Pediatr Cardiol 2019 Jan 19;40(1):234-236. Epub 2018 Dec 19.

Division of Pediatric Cardiology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

We herein describe, for the first time, the fetal presentation of a case of ventricular inversion, restrictive ventricular septal defect, pulmonary stenosis, hypertensive left ventricle and double outlet right ventricle at 34 weeks of gestational age. Postnatal echocardiography confirmed the prenatal diagnosis. The patient was subsequently successfully palliated with a left ventricle to pulmonary artery conduit. Read More

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http://dx.doi.org/10.1007/s00246-018-2048-8DOI Listing
January 2019
1 Read

Pregnancy unmasking symptoms of undiagnosed lymphangioleiomyomatosis: Case report and review of literature.

Respir Med Case Rep 2019 23;26:63-67. Epub 2018 Nov 23.

Centegra Health Care System, USA.

Cystic lung diseases are a group of disorders that appear similar on radiological studies on chest computed tomography. Each disorder is characterized by its own etiology, pathophysiology, course of progression and manifestation. Lymphangioleiomyomatosis (LAM) is one of the cystic lung diseases that can either be hereditary or sporadic. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277247PMC
November 2018
2 Reads

Using the emergency department to investigate smoking in young adults.

Ann Epidemiol 2019 Feb 24;30:44-49.e1. Epub 2018 Nov 24.

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA.

Purpose: Smoking in young adults identifies the population at risk for future tobacco-related disease. We investigated smoking in a young adult population and within high-risk groups using emergency department (ED) data in a metropolitan area.

Methods: Using the electronic health record, we performed a retrospective study of smoking in adults aged 18-30 years presenting to the ED. Read More

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http://dx.doi.org/10.1016/j.annepidem.2018.11.007DOI Listing
February 2019
3 Reads
2.000 Impact Factor

[Pulmonary glial heterotopia: Unique lesion in an infant with anencephalic twin].

Ann Pathol 2019 Feb 12;39(1):24-28. Epub 2018 Dec 12.

Service de pathologie, hôpital universitaire Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Université Diderot Paris 7 - SPC, 16, rue Huchard, 75018 Paris, France.

Pulmonary glial heterotopia is an extremely rare entity whose pathophysiology remains unclear. We report for the first time one case of pulmonary glial heterotopia occured in a one-month baby free from any malformation. She has the particularity of being born from monozygotic monochorionic twin pregnancy where her anencephalic exencephalic sister suffered a medical termination of pregnancy. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.08.006DOI Listing
February 2019
3 Reads

Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2019 Feb;23(2):277-284

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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http://link.springer.com/10.1007/s10995-018-2652-5
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http://dx.doi.org/10.1007/s10995-018-2652-5DOI Listing
February 2019
8 Reads

Postpartum flare up of systemic lupus erythematosus: Pulmonary diffused alveolar hemorrhage.

Taiwan J Obstet Gynecol 2018 Dec;57(6):906-907

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.tjog.2018.10.027DOI Listing
December 2018

Repeated pulmonary embolism with cardiac arrest after uterine artery embolization for uterine arteriovenous malformation: A case report and literature review.

Taiwan J Obstet Gynecol 2018 Dec;57(6):890-893

Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, Astana, 010000, Kazakhstan.

Objective: Uterine arteriovenous malformation (AVM) is an abnormal and nonfunctional communication between uterine arteries and veins, currently managed by uterine artery embolization (UAE). Pulmonary embolism (PE) is the most severe and life-threatening complication of this procedure.

Case Report: We report a case of 27 year-old woman with heavy vaginal bleeding and abdominal pain caused by AVM. Read More

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http://dx.doi.org/10.1016/j.tjog.2018.10.021DOI Listing
December 2018

The Differences Between Childhood and Adult Onset Antiphospholipid Syndrome.

Front Pediatr 2018 27;6:362. Epub 2018 Nov 27.

Department of Rheumatology, University College London, London, United Kingdom.

Antiphospholipid syndrome (APS) is a rare autoimmune disease of unknown etiology that represents a leading cause of acquired thromboembolism and recurrent miscarriage. It is characterized by the persistent elevated presence of pathogenic antiphospholipid auto-antibodies directed against cardiolipin, ß2-glycoprotein-I, and/or a positive lupus anticoagulant test. As with many autoimmune disorders, the pathogenesis of APS is believed to be the result of a complex interaction between environmental triggers and genetic predisposition. Read More

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http://dx.doi.org/10.3389/fped.2018.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277799PMC
November 2018
1 Read

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
26 Reads

Lifetime Spousal Violence Victimization and Perpetration, Physical Illness, and Health Risk Behaviours among Women in India.

Int J Environ Res Public Health 2018 12 4;15(12). Epub 2018 Dec 4.

Department of Research & Innovation, University of Limpopo, Turfloop 0727, South Africa.

The aim of this study was to assess the association between lifetime spousal violence victimization, spousal violence perpetration, and physical health outcomes and behaviours among women in India. In the 2015⁻2016 National Family Health Survey, a sample of ever-married women (15⁻49 years) ( = 66,013) were interviewed about spousal violence. Results indicate that 29. Read More

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http://dx.doi.org/10.3390/ijerph15122737DOI Listing
December 2018
2 Reads