13,528 results match your criteria Pulmonary Artery Catheterization


Pulmonary hypertension with massive megalosplenia: A case report.

Medicine (Baltimore) 2019 Mar;98(12):e14594

Department of Cardiology.

Rationale: Pulmonary hypertension (PH) is a complicated disease which has complex causes and poor outcome. Many factors are involved in the increase of pulmonary artery pressure. It is often difficult to identify the specific cause of a particular patient. Read More

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http://dx.doi.org/10.1097/MD.0000000000014594DOI Listing

Right-heart catheterization using antecubital venous access in patients with complex congenital heart defects and Glenn anastomosis.

Turk Kardiyol Dern Ars 2019 Mar;47(2):103-110

Department of Pediatric Cardiology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey.

Objective: Right-heart catheterization using the antecubital veins has recently regained attention, and studies demonstrating the feasibility and safety of antecubital access in adults have been published. However, no changes have been observed in the preferred entrance sites in right-heart catheterizations in children with congenital heart diseases. This article is a description of the technique and features of the antecubital venous approach in pediatric patients with complex congenital heart defects and a Glenn anastomosis. Read More

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http://dx.doi.org/10.5543/tkda.2019.70558DOI Listing
March 2019
1 Read

Acute Vasoreactivity Testing during Cardiac Catheterization of Neonates with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.

J Pediatr 2019 Mar 11. Epub 2019 Mar 11.

Section of Cardiology, Department of Pediatrics, University of Colorado Denver School of Medicine, Denver, CO.

Objectives: To assess whether better baseline pulmonary hemodynamics or positive acute vasoreactivity testing (AVT) during cardiac catheterization are associated with improved outcomes in infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH).

Study Design: This retrospective, single-center study included 26 premature neonates with BPD who underwent catheterization to evaluate PH. AVT was assessed with exposure to 100% fractional inspired oxygen with or without inhaled nitric oxide. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.004DOI Listing
March 2019
1 Read

Enhanced Recovery Pathways for Cardiac Surgery.

Curr Pain Headache Rep 2019 Mar 14;23(4):28. Epub 2019 Mar 14.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Purpose Of Review: Enhanced recovery after surgery (ERAS) has become a widespread topic in perioperative medicine over the past 20 years. The goals of ERAS are to improve patient outcomes and perioperative experience, reduce length of hospital stay, minimize complications, and reduce cost. Interventions and factors before, during, and after surgery all potentially play a role with the cumulative effect being superior quality of patient care. Read More

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http://link.springer.com/10.1007/s11916-019-0764-2
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http://dx.doi.org/10.1007/s11916-019-0764-2DOI Listing
March 2019
3 Reads

Echocardiographic assessment of left ventricular diastolic pressure.

Authors:
Anthony S McLean

Curr Opin Crit Care 2019 Mar 5. Epub 2019 Mar 5.

Department of Intensive Care Medicine, Nepean Hospital, The University of Sydney, Sydney, New South Wales, Australia.

Purpose Of Review: Knowledge of the left ventricular pressures throughout the cardiac cycle is of considerable assistance in managing a haemodynamically unstable patient. Invasive pressure measurement is the only accurate way to analyze ventricular diastolic pressures but this is not feasible outside the catheterization laboratory, whereas the use of a pulmonary artery catheter or Doppler echocardiography, using surrogate measurements, is available at the bedside. The ever-increasing trend toward noninvasive monitoring puts echocardiography at the forefront and considerable effort has been made to define its role in this setting. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000601DOI Listing
March 2019
1 Read

Computational Fluid Dynamics Characterization of Two Patient-Specific Systemic-to-Pulmonary Shunts before and after Operation.

Comput Math Methods Med 2019 3;2019:1502318. Epub 2019 Feb 3.

Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China.

Studying the haemodynamics of the central shunt (CS) and modified Blalock-Taussig shunt (MBTS) benefits the improvement of postoperative recovery for patients with an aorta-pulmonary shunt. Shunt configurations, including CS and MBTS, are virtually reconstructed for infants A and B based on preoperative CT data, and three-dimensional models of A, 11 months after CS, and B, 8 months after MBTS, are reconstructed based on postoperative CT data. A series of parameters including energy loss, wall shear stress, and shunt ratio are computed from simulation to analyse the haemodynamics of CS and MBTS. Read More

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http://dx.doi.org/10.1155/2019/1502318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378018PMC
February 2019
1 Read

Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension.

Sci Rep 2019 Mar 11;9(1):4061. Epub 2019 Mar 11.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

The presence of pulmonary hypertension (PH) significantly worsens outcomes in patients with advanced sarcoidosis, but its optimal management is unknown. We aimed to characterize a large sarcoidosis-associated pulmonary hypertension (SAPH) cohort to better understand patient characteristics, clinical outcomes, and management strategies including treatment with PH therapies. Patients at Duke University Medical Center with biopsy-proven sarcoidosis and SAPH confirmed by right heart catheterization (RHC) were identified from 1990-2010. Read More

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http://www.nature.com/articles/s41598-019-40030-w
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http://dx.doi.org/10.1038/s41598-019-40030-wDOI Listing
March 2019
2 Reads

Trends in Utilization and Outcomes of Pulmonary Artery Catheterization in Heart Failure With and Without Cardiogenic Shock.

J Card Fail 2019 Mar 8. Epub 2019 Mar 8.

Division of Advanced Heart Failure and Transplant Cardiology, Vanderbilt University Medical Center, Nashville, TN.

Background: The pulmonary artery catheter (PAC) has been used in a wide-range of critically ill patients. It is not indicated for routine care of heart failure (HF) but its role in cardiogenic shock (CS) has not been clarified.

Methods And Results: We conducted a retrospective cohort study using the National Inpatient Sample and identified a total of 9,431,944 adult patients between 2004 and 2014 admitted with the primary diagnosis of HF (n=8,516,528) or who developed CS (n= 915,416) during the index hospitalization. Read More

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http://dx.doi.org/10.1016/j.cardfail.2019.03.004DOI Listing

Preoperative balloon pulmonary angioplasty enabled noncardiac surgery of a patient with chronic thromboembolic pulmonary hypertension (CTEPH): A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14807

Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo.

Rationale: Chronic thromboembolic pulmonary hypertension (CTEPH) is a disease with a poor prognosis, characterized by chronic thromboembolic obstruction of the pulmonary arteries and pulmonary hypertension. Balloon pulmonary angioplasty (BPA) is a newly emergent treatment for CTEPH, which may substitute pulmonary endarterectomy, the standard but more invasive treatment for CTEPH. Here, we report the case of a CTEPH patient who underwent 2 noncardiac surgeries without complications after preoperative intervention of BPA. Read More

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http://Insights.ovid.com/crossref?an=00005792-201903080-0006
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http://dx.doi.org/10.1097/MD.0000000000014807DOI Listing
March 2019
1 Read

Total Anomalous Pulmonary Venous Connection Beyond the First Decade of Life.

World J Pediatr Congenit Heart Surg 2019 Mar;10(2):185-191

1 Departments of Cardiothoracic and Vascular Surgery, Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Objective:: We report our experience with surgery for total anomalous pulmonary venous connection (TAPVC) beyond first decade of life.

Methods:: Between January 1987 and July 2017, 98 patients ≥ten years underwent TAPVC repair. Their detailed case-records were analyzed. Read More

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http://journals.sagepub.com/doi/10.1177/2150135118822792
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http://dx.doi.org/10.1177/2150135118822792DOI Listing
March 2019
2 Reads

Catheterization Performed in the Early Postoperative Period After Congenital Heart Surgery in Children.

Pediatr Cardiol 2019 Mar 4. Epub 2019 Mar 4.

Universidad Pontificia Bolivariana, Medellín, Colombia.

The aim of this study was to describe pediatric patients who underwent early postoperative cardiac catheterization after congenital heart surgery, their clinical indications, findings, interventions, and complications in a cardiovascular center. A descriptive retrospective study was performed. All catheterizations performed within 6 weeks after congenital heart surgery between January 2004 and December 2014 were reviewed. Read More

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http://link.springer.com/10.1007/s00246-019-02078-3
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http://dx.doi.org/10.1007/s00246-019-02078-3DOI Listing
March 2019
3 Reads

A prospective evaluation of the diagnostic accuracy of the physical examination for pulmonary hypertension.

Chest 2019 Feb 28. Epub 2019 Feb 28.

Section of Respirology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada. Electronic address:

Background: The utility of physical examination findings for pulmonary hypertension (PH) is not well established. The purpose of this study was to prospectively evaluate the diagnostic performance of the physical examination for detecting PH.

Methods: Consecutive patients undergoing right heart catheterization (n=116) were examined by an attending physician, medical resident and medical student in a blinded fashion. Read More

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http://dx.doi.org/10.1016/j.chest.2019.01.035DOI Listing
February 2019
1 Read

Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension.

Arterioscler Thromb Vasc Biol 2019 Feb 28:ATVBAHA118311992. Epub 2019 Feb 28.

Heart Center and Shanghai Institution of Pediatric Congenital Heart Diseases, Shanghai Children's Medical Center, National Children's Medical Center, China (H.Z.).

Objective- Pulmonary arterial hypertension is characterized by progressive pulmonary vascular remodeling and persistently elevated mean pulmonary artery pressures and pulmonary vascular resistance. We aimed to investigate whether transthoracic pulmonary artery denervation (TPADN) attenuated pulmonary artery (PA) remodeling, improved right ventricular (RV) function, and affected underlying mechanisms. We also explored the distributions of sympathetic nerves (SNs) around human PAs for clinical translation. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311992DOI Listing
February 2019
1 Read
6.000 Impact Factor

Hemodynamic Support Using Percutaneous Transfemoral Impella 5.0 and Impella RP for Refractory Cardiogenic Shock.

Case Rep Cardiol 2019 23;2019:4591250. Epub 2019 Jan 23.

Department of Cardiovascular Medicine, Beaumont Health System, Royal Oak, MI, USA.

Acute myocardial infarction (AMI) resulting in cardiogenic shock continues to be a substantial source of morbidity and mortality despite advances in recognition and treatment. Prior to the advent of percutaneous and more durable left ventricular support devices, prompt revascularization with the addition of vasopressors and inotropes were the standard of care in the management of this critical population. Recent published studies have shown that in addition to prompt revascularization, unloading of the left ventricle with the placement of the Impella percutaneous axillary flow pump can lead to improvement in mortality. Read More

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http://dx.doi.org/10.1155/2019/4591250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364115PMC
January 2019
1 Read

Unilateral absence of the pulmonary veins: an unusual diagnosis with characteristic imaging findings.

Clin Imaging 2019 Jan 30;55:107-111. Epub 2019 Jan 30.

Department of Radiology, Helen DeVos Children's Hospital and Spectrum Health, Advanced Radiology Services, Grand Rapids, MI, United States of America; New York Medical College, Valhalla, NY, United States of America.

Background: Congenital unilateral absence of the pulmonary vein (UCAPV) is a rare entity with characteristic clinical and imaging findings. Despite its congenital nature, the radiographic findings and symptoms of UCAPV may not be recognized at birth and patients may present in childhood or early adulthood with findings that may mimic other diagnoses.

Methods: The evolution of imaging findings in UCAPV is presented through two cases, one of which demonstrates the progression of findings over several years. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.022DOI Listing
January 2019
3 Reads

IMPACT Registry and National Pediatric Cardiology Quality Improvement Collaborative: Contributions to Quality in Congenital Heart Disease.

World J Pediatr Congenit Heart Surg 2019 01;10(1):72-80

3 Division of Pediatric Cardiology, Children's Healthcare of Atlanta-Emory University, Atlanta, GA, USA.

The IMproving Pediatric and Adult Congenital Treatments (IMPACT) Registry and the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) are two efforts initiated to improve outcomes in the congenital heart disease field. The IMPACT Registry is focused on evaluating the use, risks, adverse events (AEs), and outcomes associated with diagnostic and common interventional catheterization procedures in all children and adults with congenital heart disease. Utilizing a modular approach, the common procedures include diagnostic cardiac catheterization, atrial septal defect device closure, patent ductus arteriosus device closure, pulmonary valvuloplasty, aortic valvuloplasty, balloon and stent angioplasty of coarctation of the aorta, pulmonary artery balloon stent angioplasty, transcatheter pulmonary valve replacement, and electrophysiology procedures including radiofrequency ablation. Read More

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http://dx.doi.org/10.1177/2150135118815059DOI Listing
January 2019
1 Read

Classification scheme for ductal morphology in cyanotic patients with ductal dependent pulmonary blood flow and association with outcomes of patent ductus arteriosus stenting.

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.

Objectives: To devise a classification scheme for ductal morphology in patients with ductal dependent pulmonary blood flow (PBF) that can be used to assess outcomes.

Background: The impact of ductal morphology on outcomes following patent ductus arteriosus (PDA) stenting is not well defined.

Methods: Patients <1 year of age who underwent PDA stenting for ductal dependent PBF at the four centers comprising the Congenital Catheterization Research Collaborative (CCRC) were included. Read More

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http://doi.wiley.com/10.1002/ccd.28125
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http://dx.doi.org/10.1002/ccd.28125DOI Listing
February 2019
4 Reads

Predictors of operability in children with severe pulmonary hypertension associated with congenital heart disease.

Chin Med J (Engl) 2019 Apr;132(7):811-818

Department of Pediatric Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Science/Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510080, China.

Background: Pulmonary artery hypertension associated with congenital heart disease (PAH-CHD) occurs predominantly among patients with uncorrected CHD. Treatment of severe pediatric PAH-CHD remains a major intractability. This study evaluated the predictors and prognoses of children with PAH-CHD who underwent surgical correction. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000145DOI Listing

A dramatic learning curve of extracardiac Fontan operation in the modern era.

Asian Cardiovasc Thorac Ann 2019 Mar;27(3):172-179

1 Pediatric Cardiac Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Turkey.

Background: This study aimed to describe the learning curve of the extracardiac Fontan procedure in a single center and to analyze the changes in clinical applications and outcomes.

Methods: A retrospective chart review of all extracardiac Fontan patients in a single tertiary care center was undertaken. Patients with a diagnosis of hypoplastic left heart syndrome and those who had undergone a lateral tunnel modification, intra/extracardiac Fontan, Kawashima procedure, or inferior vena cava-to-azygous vein connection were excluded from the analysis. Read More

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http://dx.doi.org/10.1177/0218492319831832DOI Listing
March 2019
1 Read

Lung diffusion capacity in advanced heart failure: relation to central haemodynamics and outcome.

ESC Heart Fail 2019 Feb 19. Epub 2019 Feb 19.

Department of Cardiology, Rigshospitalet, 2142, 9 Blegdamsvej, DK-2100, Copenhagen, Denmark.

Aims: Patients with heart failure (HF) are known to have a reduced pulmonary diffusion capacity for carbon monoxide (D ), but little is known about how lung function relates to central haemodynamics. The aim of this study was to investigate the association between haemodynamic variables and pulmonary diffusion capacity adjusted for alveolar volume in congestive HF patients and to analyse how predicted D /V affects mortality in relation to the haemodynamic status.

Methods And Results: We retrospectively studied right heart catheterization (RHC) and lung function data on 262 HF patients (mean age 51 ± 13 years) with a left ventricular ejection fraction < 45% referred non-urgently for evaluation for heart transplantation (HTX) or left ventricular assist device (LVAD). Read More

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http://dx.doi.org/10.1002/ehf2.12401DOI Listing
February 2019
1 Read

The role of diagnostic cardiac catheterization for children with congenital heart diseases: local experience.

Authors:
Reham Wagdy

Arch Med Sci Atheroscler Dis 2018 28;3:e72-e79. Epub 2018 Jun 28.

Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Introduction: Despite the development of non-invasive tools of investigations for congenital heart diseases (CHDs), still the role of diagnostic cardiac catheterization (DCC) cannot be undermined. The study aimed to analyze the clinical profile of indicated CHDs cases at our center for DCC to evaluate the contribution of DCC in patients' management plans.

Material And Methods: The study checked files of cases performed DCC between 2011 and 2012 at the pediatric catheterization unit of Alexandria University Children's Hospital by the same operator. Read More

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http://dx.doi.org/10.5114/amsad.2018.76824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374569PMC
June 2018
1 Read

Novel Left Heart Catheterization Ramp Protocol to Guide Hemodynamic Optimization in Patients Supported With Left Ventricular Assist Device Therapy.

J Am Heart Assoc 2019 Feb;8(4):e010232

1 Department of Cardiovascular Diseases Mayo Clinic Rochester MN.

Background Left ventricular (LV) hemodynamic assessment has been sparsely performed in patients supported on continuous-flow LV assist devices (cf LVADs ). Insight into dynamic changes of left heart parameters during ramp studies may improve LV assist device optimization and evaluate pathology. Methods and Results To complement right heart catheterization, a novel technique for left heart catheterization in patients with a cf LVAD was developed. Read More

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http://dx.doi.org/10.1161/JAHA.118.010232DOI Listing
February 2019
1 Read

Pulmonary arterial hypertension in Saudi patients with systemic sclerosis: Clinical and hemodynamic characteristics and mortality.

Ann Thorac Med 2019 Jan-Mar;14(1):83-89

Department of Medicine, Division of Rheumatology, King Saud University, Riyadh, Saudi Arabia.

Background: Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality in patients with systemic sclerosis (SSc). The objective of this study is to describe the clinical characteristics, mortality, and predictors of SSc-PAH in Saudi patients.

Methods: Retrospective chart review study of SSc patients who were followed for at least 1 year in three tertiary care centers in Saudi Arabia was conducted. Read More

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http://dx.doi.org/10.4103/atm.ATM_33_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341865PMC
February 2019
1 Read

Higher Diuretic Requirements in Acute Heart Failure With Admission Hyponatraemia Versus Normonatraemia.

Heart Lung Circ 2019 Jan 28. Epub 2019 Jan 28.

Division of Cardiovascular Medicine, Linda and Jack Gill Heart Institute, University of Kentucky, Lexington, KY, USA.

Background: Diuretic requirements in patients with acute decompensated heart failure (ADHF) and hyponatraemia versus normonatraemia on admission has not been previously explored.

Methods: The Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial dataset was utilised to examine the characteristics and diuretic requirements of patients with ADHF with hyponatraemia or normonatraemia on admission.

Results: Patients with ADHF and admission hyponatraemia (n = 103, average Na 130. Read More

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http://dx.doi.org/10.1016/j.hlc.2018.12.014DOI Listing
January 2019
2 Reads

Comparison of arterial and venous blood-gas values in anesthetized Dorset cross-bred lambs (Ovis aries) using a point-of-care analyzer.

Vet Anaesth Analg 2019 Mar 21;46(2):209-213. Epub 2019 Jan 21.

Department of Comparative Medicine, Penn State Milton S Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.

Objective: To determine the degree of agreement between arterial and venous blood gases in anesthetized lambs using a point-of-care analyzer.

Study Design: Prospective experimental study.

Animals: A group of 12 female Dorset cross-bred lambs, weighing 37. Read More

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http://dx.doi.org/10.1016/j.vaa.2018.12.003DOI Listing
March 2019
1 Read

Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.

Front Cardiovasc Med 2018 25;5:195. Epub 2019 Jan 25.

Department of Medicine, Queen's University, Kingston, ON, Canada.

Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die from right ventricular failure (RVF). Alterations in mitochondrial metabolism, notably impaired glucose oxidation, and increased mitochondrial fission, contribute to right ventricle (RV) dysfunction in PH. We hypothesized that the impairment of RV and left ventricular (LV) function in group 2 PH results in part from a proglycolytic isoform switch from pyruvate kinase muscle (PKM) isoform 1 to 2 and from increased mitochondrial fission, due either to upregulation of expression of dynamin-related protein 1 (Drp1) or its binding partners, mitochondrial dynamics protein of 49 or 51 kDa (MiD49 or 51). Read More

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http://dx.doi.org/10.3389/fcvm.2018.00195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355690PMC
January 2019
2 Reads

Harvest of Endothelial Cells from the Balloon Tips of Swan-Ganz Catheters after Right Heart Catheterization.

J Vis Exp 2019 Jan 23(143). Epub 2019 Jan 23.

Cardiovascular Institute, Allegheny Health Network.

A variety of pathologies lead to pulmonary hypertension (PH), which is defined as a mean pulmonary artery pressure exceeding 25 mmHg at rest. To further diagnose and manage PH, patients undergo repeated right heart catheterizations (RHC) wherein a Swan-Ganz catheter is advanced into a branch of the pulmonary artery and a balloon is inflated to wedge the catheter tip. This article illustrates a protocol whereby pulmonary artery endothelial cells (PAECs) may be harvested from the balloon tips of Swan-Ganz catheters after RHC, and purified with an anti- CD146 affinity column technique to purify putative PAECs. Read More

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http://dx.doi.org/10.3791/58353DOI Listing
January 2019
1 Read

Intraesophageal aortopulmonary collateral artery occlusion in an infant with Tetralogy of Fallot and flow-dependent major aortopulmonary collateral arteries.

Cardiovasc Pathol 2019 Mar - Apr;39:74-76. Epub 2019 Jan 9.

Patients with flow-dependent aortopulmonary collateral arteries often exhibit tenuous clinical statuses. Here we present an infant with Tetralogy of Fallot with pulmonary atresia (TOF-PA) and major aortopulmonary collateral arteries (MAPCAs) who experienced clinically significant oxygen desaturations during feedings. These frequent episodes were attributed to gastroesophageal reflux. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.009DOI Listing
January 2019
2 Reads

Working backward: Retrograde balloon angioplasty of atretic arteries in chronic thromboembolic pulmonary hypertension.

Catheter Cardiovasc Interv 2019 Feb 5. Epub 2019 Feb 5.

Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.

We describe a patient with chronic thromboembolic pulmonary hypertension who presented to the pediatric cardiac catheterization laboratory for peripheral pulmonary artery recanalization and angioplasty. This case report outlines serial pulmonary arterial rehabilitation via a retrograde approach through intrapulmonary collateral arterial connections. Read More

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http://dx.doi.org/10.1002/ccd.28115DOI Listing
February 2019
1 Read

Clinical implication of right-sided augmentation pressure in patients with pulmonary hypertension.

Pulm Circ 2019 Jan-Mar;9(1):2045894019833352

Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Similar to left ventricular and aortic pressure waveforms, augmentation pressure (AugPr) in the right ventricular (RV) pressure waveform is also frequent in patients with pulmonary hypertension (PH). This study sought to evaluate whether the degree of AugPr in RV pressure waveform has prognostic value. Forty-one patients (13 men; mean age = 50. Read More

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http://dx.doi.org/10.1177/2045894019833352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388450PMC
February 2019

Acute Iloprost Inhalation Improves Right Ventricle Function in Pulmonary Artery Hypertension: A Cardiac Magnetic Resonance Study.

Front Pharmacol 2018 21;9:1550. Epub 2019 Jan 21.

Tianjin Medical University General Hospital, Tianjin, China.

Right ventricle (RV) function is among the most important prognostic factors for pulmonary arterial hypertension (PAH) patients. Inhaled iloprost, an inhaled member of the prostacyclin family, is effective for the treatment of severe PAH and acute RV failure. However, the acute effects of iloprost on RV physiology have not been thoroughly explored in the past. Read More

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http://dx.doi.org/10.3389/fphar.2018.01550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348276PMC
January 2019
5 Reads

DAN plays important compensatory roles in systemic-to-pulmonary shunt associated pulmonary arterial hypertension.

Acta Physiol (Oxf) 2019 Feb 4:e13263. Epub 2019 Feb 4.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Aim: Proteins mainly expressed in normal lungs and significantly changed in lungs exposed to systemic-to-pulmonary shunts might be promising targets for pulmonary arterial hypertension induced by congenital heart diseases (PAH/CHD). This study aimed to investigate the potential role of differential screening-selected gene aberrative in neuroblastoma (DAN) in PAH/CHD.

Methods: PAH was surgically induced by the combined surgery (right pulmonary artery ligation and left cervical systemic-to-pulmonary shunt) in Sprague-Dawley (SD) rats. Read More

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http://dx.doi.org/10.1111/apha.13263DOI Listing
February 2019
1 Read
4.382 Impact Factor

Plasma levels of melatonin in dilated cardiomyopathy.

J Pineal Res 2019 Feb 4:e12564. Epub 2019 Feb 4.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Background: Melatonin is a multifunctional indolamine and has a cardioprotective role in a variety of cardiovascular processes via antioxidant, anti-inflammatory, antihypertensive, antithrombotic, and antilipemic effects. It has been reported that lower levels of circulating melatonin are significantly associated with a higher risk of acute myocardial infarction (AMI) and later cardiac remodeling. However, levels of melatonin in patients with dilated cardiomyopathy (DCM) and associations between melatonin levels and cardiac function remain unclear. Read More

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http://dx.doi.org/10.1111/jpi.12564DOI Listing
February 2019
1 Read

Computed tomography-measured pulmonary artery to aorta ratio and EUTOS score for detecting dasatinib-induced pulmonary arterial hypertension.

Int J Cardiovasc Imaging 2019 Feb 4. Epub 2019 Feb 4.

Division of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan.

Background: Periodic echo-based screening to detect early stages of a rare complication of dasatinib, pulmonary arterial hypertension (PAH), is inefficient and weakens the potential benefit of dasatinib as a potent drug for chronic myelogenous leukemia (CML). This study aimed to identify the predisposing factors of DASA-PAH to stratify high-risk patients for dasatinib-induced PAH (DASA-PAH).

Methods: Sixty consecutive adult patients who received dasatinib were enrolled in this case-control study. Read More

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http://dx.doi.org/10.1007/s10554-019-01548-2DOI Listing
February 2019
2 Reads

Perspectives of using pulmonary arterial stiffness indicators to evaluate the prognosis  of patients with pulmonary arterial hypertension.

Ter Arkh 2018 Feb;90(1):86-92

Almazov National Medical Research Centre.

Aim: The aim of the study was to characterize the mechanical properties of the pulmonary arterial wall (PA) in patients with pulmonary arterial hypertension (PAH) using magnetic resonance imaging (MRI) of the heart, and to determine their diagnostic and prognostic value.

Materials And Methods: 57 patients with PAH were examined. The diagnosis of PAH was verified according to the recommendations of the ERS/ESC from 2015. Read More

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http://dx.doi.org/10.26442/terarkh201890186-92DOI Listing
February 2018
1 Read

Multicenter Analysis of Early Childhood Outcomes After Repair of Truncus Arteriosus.

Ann Thorac Surg 2019 Feb 26;107(2):553-559. Epub 2018 Oct 26.

Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, Indiana.

Background: Literature describing morbidity and mortality after truncus arteriosus repair is predominated by single-center reports. We created and analyzed a multicenter dataset to identify risk factors for late mortality and right ventricle-to-pulmonary artery (RV-PA) conduit reintervention for this patient population.

Methods: We retrospectively collected data on children who underwent repair of truncus arteriosus without concomitant arch obstruction at 15 centers between 2009 and 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183152
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http://dx.doi.org/10.1016/j.athoracsur.2018.08.094DOI Listing
February 2019
6 Reads

Pump Speed Optimization in Patients Implanted With the HeartMate 3 Device.

Transplant Proc 2019 Jan - Feb;51(1):206-209. Epub 2018 Jun 30.

Department Cardiac Surgery and Heart Transplantation, San Camillo Hospital, Rome, Italy.

Background: Pump speed optimization in patients implanted with a ventricular assist device represents a major challenge during the follow-up period. We present our findings on whether combined invasive hemodynamic ramp tests and cardiopulmonary exercise testing (CPX) can help optimize patient management.

Methods: Eighteen patients implanted with a HeartMate 3 (HM3) device underwent ramp tests with right heart catheterization (including central venous pressure [CVP], pulmonary artery pressure, pulmonary capillary wedge pressure [PCWP], and blood pressure) and echocardiography. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.210DOI Listing
June 2018
3 Reads

Soluble neprilysin does not correlate with prognosis in pulmonary hypertension.

ESC Heart Fail 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiovascular Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Aims: It has been reported that circulating soluble neprilysin (sNEP), which catalyses the degradation of several vasodilator peptides such as natriuretic peptides, predicts prognosis in heart failure patients with reduced ejection fraction. Hypoxia-induced decrease in NEP expression in lungs has been reported. However, the associations between sNEP and haemodynamic parameters, as well as the prognostic impact of sNEP in pulmonary hypertension (PH), remain unclear. Read More

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http://doi.wiley.com/10.1002/ehf2.12404
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http://dx.doi.org/10.1002/ehf2.12404DOI Listing
January 2019
8 Reads

Pulmonary Artery Banding in Post-tricuspid Congenital Cardiac Shunting Defects with High Pulmonary Vascular Resistance.

Pediatr Cardiol 2019 Jan 23. Epub 2019 Jan 23.

Division of Cardiac Critical Care, and the Pulmonary Hypertension Program, Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.

Reports of "treat and repair" of cardiac shunting lesions with inoperably high pulmonary vascular resistance (PVR) mostly concern pre-tricuspid defects; post-tricuspid lesions are different. We report our experience with pulmonary artery (PA) banding ± targeted pulmonary hypertension medications in five patients with a large VSD and inoperably high PVR, and review previous reports of PA banding with post-tricuspid defects. Three of our 5 patients had mean PAP > 50 mmHg after banding and no or only a transient fall in PVR. Read More

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http://dx.doi.org/10.1007/s00246-019-02054-xDOI Listing
January 2019
1 Read

Double-arterial cannulation during aortic arch reconstruction in pediatric patients.

Multimed Man Cardiothorac Surg 2018 Dec 17;2018. Epub 2018 Dec 17.

Division of Pediatric Cardiac Surgery Children's Heart Center Linz Linz, Austria.

Aortic arch reconstruction is a highly demanding procedure in congenital heart surgery. The 2 conventional options for cardiopulmonary bypass - deep hypothermic circulatory arrest or antegrade cerebral perfusion - both result in lack of perfusion of the entire or lower body.  In 2003, the Children's Heart Center Linz started to use a double-arterial cannulation technique for aortic arch reconstructions in order to provide whole body perfusion during the entire operation. Read More

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http://dx.doi.org/10.1510/mmcts.2018.040DOI Listing
December 2018
5 Reads

Idiopathic, heritable and veno-occlusive pulmonary arterial hypertension in childhood: computed tomography angiography features in the initial assessment of the disease.

Pediatr Radiol 2019 Jan 16. Epub 2019 Jan 16.

M3C-Necker, Congenital and Pediatric Cardiology, Hôpital Universitaire Necker-Enfants malades, Paris, France.

Background: In children, idiopathic and heritable pulmonary arterial hypertension present echocardiographic and heart catheterization findings similar to findings in pulmonary veno-occlusive disease.

Objective: To provide a systematic analysis of CT angiography anomalies in children with idiopathic or heritable pulmonary arterial hypertension, or pulmonary veno-occlusive disease. We also sought to identify correlations between CT findings and patients' baseline characteristics. Read More

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http://dx.doi.org/10.1007/s00247-018-04331-yDOI Listing
January 2019
1 Read

Unusual Sequence of Events in a Case of Takotsubo Syndrome.

Case Rep Cardiol 2018 13;2018:5498052. Epub 2018 Dec 13.

Department of Cardiology, Maimonides Medical Center, Brooklyn, NY 11219, USA.

A 73-year-old female with multiple comorbidities including coronary artery disease was admitted for an elective PCI of a lesion detected in the RCA. On the day of the planned PCI, shortly after right femoral artery cannulation, the patient developed a sudden complete heart block requiring the administration atropine and insertion of a temporary pacemaker. Concomitantly, the patient developed acute pulmonary edema, hypotension, and hypoxia requiring intubation for mechanical ventilation. Read More

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http://dx.doi.org/10.1155/2018/5498052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311793PMC
December 2018
2 Reads

Evolution of hemodynamic forces in the pulmonary tree with progressively worsening pulmonary arterial hypertension in pediatric patients.

Biomech Model Mechanobiol 2019 Jan 12. Epub 2019 Jan 12.

Departments of Pediatrics and Bioengineering, Stanford University, Stanford, CA, USA.

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling resulting in right ventricular (RV) dysfunction and ultimately RV failure. Mechanical stimuli acting on the vessel walls of the full pulmonary tree have not previously been comprehensively characterized. The goal of this study is to characterize wall shear stress (WSS) and strain in pediatric PAH patients at different stages of disease severity using computational patient-specific modeling. Read More

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http://dx.doi.org/10.1007/s10237-018-01114-0DOI Listing
January 2019
3 Reads

Gasometric gradients between blood obtained from the pulmonary artery wedge and pulmonary artery positions in pulmonary arterial hypertension.

Respir Res 2019 Jan 8;20(1). Epub 2019 Jan 8.

Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue A-90, Cleveland, OH, 44195, USA.

Introduction: Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their association with disease severity and survival.

Methods: During right heart catheterization (RHC) we obtained blood from pulmonary artery (PA) and pulmonary artery wedge (PAW) positions and used co-oximetry to test their gasometric differences. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s12931-018-0969-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325872PMC
January 2019
5 Reads

Reduced right ventricular output reserve in patients with systemic sclerosis and mildly elevated pulmonary arterial pressures.

Arthritis Rheumatol 2019 Jan 7. Epub 2019 Jan 7.

Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany.

Objective: The objective of this prospective study was to evaluate right ventricular function and pulmonary arterial compliance (PAC=stroke volume/pulse pressure) at rest and during exercise in patients with systemic sclerosis (SSc) with normal mean pulmonary artery pressures (mPAP) at rest, mildly elevated mPAP (mPAP 21-24mmHg) and manifest pulmonary hypertension (mPAP≥25mmHg).

Methods: Patients with SSc (n=112) underwent clinical assessment and right heart catheterization at rest and during exercise and were divided into three groups according to their resting mPAP values: normal mPAP (≤20mmHg), mildly elevated mPAP (21-24mmHg) and pulmonary hypertension (PH, mPAP ≥25mmHg). Results were compared between groups by ANOVA followed by post-hoc student's t-test. Read More

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http://dx.doi.org/10.1002/art.40814DOI Listing
January 2019
2 Reads

Electrocardiogram signs of right ventricular hypertrophy may help identify pulmonary hypertension in patients with dilated cardiomyopathy.

Int J Cardiol Heart Vasc 2019 Mar 27;22:61-66. Epub 2018 Dec 27.

Department of Cardiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.

Objective: To the authors' knowledge, limited data are available regarding the association between Electrocardiogram (ECG) signs of right ventricular hypertrophy (RVH) and pulmonary hypertension (PH) in patients with dilated cardiomyopathy (DCM). We aimed to assess the accuracy of the recommended ECG criteria of RVH for predicting PH in patients with DCM.

Methods: According to the definition of PH (mPAP ≥ 25 mm Hg), 35 patients with DCM were divided into 2 groups: DCM with PH (n = 22) and DCM without PH (n = 13). Read More

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http://dx.doi.org/10.1016/j.ijcha.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307311PMC
March 2019
13 Reads

Cardiac CT to assess the risk of coronary compression in patients evaluated for percutaneous pulmonary valve implantation.

Eur J Radiol 2019 Jan 22;110:88-96. Epub 2018 Nov 22.

Department of Radiology, Erasmus Medical Center, 's Gravendijkwal 230, 3015, CE Rotterdam, The Netherlands; Department of Cardiology, Erasmus Medical Center, 's Gravendijkwal 230, 3015, CE Rotterdam, The Netherlands.

Background: Coronary compression (CC) is a life threatening complication that can occur during percutaneous pulmonary valve implantation (PPVI). We describe our experience using cardiac CT prior to PPVI to identify patients at high CC-risk due to a close relationship between the coronary arteries and pulmonary trunk (PT).

Methods: A retrospective evaluation of candidates for PPVI who underwent CT prior to the procedure was done. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.11.018DOI Listing
January 2019
2 Reads

Common Arterial Trunk: Physiology, Imaging, and Management.

Semin Cardiothorac Vasc Anesth 2018 Dec 29:1089253218821382. Epub 2018 Dec 29.

3 Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Common arterial trunk (CAT), or truncus arteriosus, is a rare form of cyanotic congenital heart disease and is highly associated with DiGeorge syndrome (microdeletion 22q11.2). Prenatal diagnosis is highly feasible, allowing proper delivery planning and postnatal management. Read More

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http://journals.sagepub.com/doi/10.1177/1089253218821382
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http://dx.doi.org/10.1177/1089253218821382DOI Listing
December 2018
17 Reads

Surgical repair of Tetralogy of Fallot following primary palliation: Right ventricular outflow track stenting versus modified Blalock-Taussig shunt.

Indian Heart J 2018 Dec 24;70 Suppl 3:S394-S398. Epub 2018 Jun 24.

Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Tetralogy of Fallot (TOF) is a cyanotic disease requiring early intervention. We assessed the effect of right ventricular outflow tract (RVOT) stenting versus modified Blalock-Taussig shunt (mBTS) on outcomes of surgical repair of TOF.

Methods: Fifteen palliated TOF infants underwent complete repair surgery. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309724PMC
December 2018
2 Reads

EFFECTS OF A SUPPLEMENTAL ETORPHINE DOSE ON PULMONARY ARTERY PRESSURE AND CARDIAC OUTPUT IN IMMOBILIZED, BOMA-HABITUATED WHITE RHINOCEROS ( CERATOTHERIUM SIMUM): A PRELIMINARY STUDY.

J Zoo Wildl Med 2018 Dec;49(4):849-855

The effects of etorphine on the pulmonary vascular system of white rhinoceros ( Ceratotherium simum) have not been described and could play a role in the severe hypoxemia that develops after immobilization with etorphine-based drug combinations. Characterization of these effects requires measurement of pulmonary vascular pressures and cardiac output (CO). To refine a technique for pulmonary arterial catheterization, five boma-habituated white rhinoceros (three females and two males weighing 1,012-1,572 kg) were immobilized by remote injection with etorphine plus azaperone followed by butorphanol. Read More

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http://www.bioone.org/doi/10.1638/2017-0120.1
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http://dx.doi.org/10.1638/2017-0120.1DOI Listing
December 2018
8 Reads