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    Neurolymphomatosis in non-Hodgkin lymphoma with cranial multineuritis: A case report.
    Medicine (Baltimore) 2018 Apr;97(15):e0303
    Department of Hematology.
    Rationale: Neurolymphomatosis (NL) is a rare syndrome of lymphoma and leukemic infiltration of cranial or peripheral nerves.

    Patient Concerns: We report a case of non-Hodgkin Lymphoma (NHL) in a 24-year-old man presented with difficulty in swallowing, hypersalivation, hoarseness, ptosis, facial paralysis, and facial hypoesthesia associated with NL.

    Diagnosis: NL was diagnosed based upon cranial magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) examination. Read More

    Immunohistochemical expression of hypoxia-inducible factor-1α in stromal cells of vaginal tissue in post-menopausal women with pelvic organ prolapse.
    Indian J Med Res 2017 11;146(Suppl):S63-S67
    Clinical Department of Pathology, Split University Hospital Center, Split, Croatia.
    Background & Objectives: Pelvic organ prolapse (POP) is a common medical condition that affects adult women of different ages. The support of a normal pelvic floor is the result of complex interactions between ligaments, muscles, connective tissue and vaginal walls. Hypoxia and oxidative stress can reduce protein synthesis in the pelvic muscles that may contribute to muscular atrophy. Read More

    Additional treatments, satisfaction, symptoms and quality of life in women 1 year after vaginal and abdominal pelvic organ prolapse repair.
    Int Urol Nephrol 2018 Mar 16. Epub 2018 Mar 16.
    Beaumont Health, 3535 W. 13 Mile Road, Room 428, Urology Administration, Royal Oak, MI, 48067, USA.
    Objectives: To evaluate additional treatments, symptoms, satisfaction and quality of life 1 year after vaginal and abdominal pelvic organ prolapse (POP) repair.

    Methods: Adult women enrolled in a prospective POP database were reviewed. Baseline and outcomes data 1 year after surgery were collected including the Pelvic Floor Distress Inventory (PFDI) and mailed surveys. Read More

    Quantitative Assessment of Dry Eye Parameters After Muller's Muscle-Conjunctival Resection.
    Ophthal Plast Reconstr Surg 2018 Mar 14. Epub 2018 Mar 14.
    Department of Ophthalmology.
    Purpose: Muller's muscle-conjunctival resection (MMCR) is a highly effective technique to correct upper eyelid ptosis. However, several authorities have raised concerns about the possibility of postoperative ocular surface dryness. This study was performed to assess the impact of MMCR on clinically meaningful parameters of the ocular surface. Read More

    Surgically induced weight loss results in a rapid and consistent improvement of female pelvic floor symptoms.
    Scand J Urol 2018 Mar 13:1-6. Epub 2018 Mar 13.
    b E. Wolfson Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
    Objective: The aim of this study was to evaluate the effect over time of bariatric surgery on female pelvic floor symptoms.

    Methods: In total, 160 consecutive adult women were requested to complete four anonymous questionnaires [International Consultation on Incontinence Questionnaire (ICIQ), Bristol Female Lower Urinary Tract Symptoms (BFLUTS), Pelvic Floor Distress Inventory (PFDI-20) and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12)] before bariatric surgery and at 3-6 months and 12-24 months postoperatively. Strict criteria were used to define clinically significant urinary incontinence (UI), pelvic organ prolapse (POP) and colorectal-anal (CRA) symptoms. Read More

    Complications of non-continent cutaneous urinary diversion in adults with spinal cord injury: a retrospective study.
    Spinal Cord 2018 Mar 7. Epub 2018 Mar 7.
    Department of Urology, Pitié-Salpêtrière Academic Hospital, Assistance Publique-Hôpitaux de Paris, Pierre and Marie Curie Medical School, Sorbonne Universités, Paris 6 University, Paris, France.
    Study Design: Retrospective cohort study.

    Objectives: To report the long-term complications of non-continent cutaneous urinary diversion (NCCUD) in adult patients with spinal cord injury (SCI).

    Setting: Hospital in Paris, France. Read More

    Pelvic Organ Prolapse and Pregnancy in the Female Bladder Exstrophy Patient.
    Curr Urol Rep 2018 Feb 26;19(3):18. Epub 2018 Feb 26.
    Department of Urologic Surgery, Vanderbilt University Medical Center, A-1302 Medical Center North, Nashville, TN, 37232-2765, USA.
    Purpose Of Review: Classic bladder exstrophy (BE) remains one of the most demanding reconstructive challenges encountered in urology. In female BE patients, the long-term sequela of both primary and revision genitoplasty, as well as intrinsic pelvic floor deficits, predispose adult women to significant issues with sexual function, pelvic organ prolapse (POP), and complexities with reproductive health.

    Recent Findings: Contemporary data suggest 30-50% of women with BE develop prolapse at a mean age of 16 years. Read More

    FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells.
    Endocrinology 2018 Apr;159(4):1690-1703
    Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California.
    Germline knockout studies in female mice demonstrated an essential role for forkhead box L2 (FOXL2) in early follicle development, whereas an inducible granulosa cell (GC)-specific deletion of Foxl2 in adults has shown ovary-to-testis somatic sex reprogramming. In women, over 120 different germline mutations in the FOXL2 gene have been shown to cause blepharophimosis/ptosis/epicantus inversus syndrome associated with or without primary ovarian insufficiency. By contrast, a single somatic mutation (FOXL2C134W) accounts for almost all adult-type GC tumors (aGCTs). Read More

    Surgical Treatment of Recurrent Rectal Prolapse in an Adult Female Black-crested Mangabey () by Colopexy.
    Comp Med 2018 Feb;68(1):80-83
    Chicago Zoological Society, Brookfield Zoo, Brookfield, Illinois.
    A 13-y-old, multiparous female black-crested mangabey (Lophocebus aterrimus) underwent surgical treatment for chronically recurring rectal prolapse by laparotomy and subsequent colopexy. Initially, a laparoscopic approach was attempted but was converted to an open approach after intraabdominal adhesions were noted. The colopexy was performed through a ventral midline incision, with no complications intraoperatively or postoperatively. Read More

    Epidemiological profile of spinal cord injuries at a tertiary rehabilitation center in Kuwait.
    Spinal Cord Ser Cases 2018 22;4. Epub 2018 Jan 22.
    Physical Medicine and Rehabilitation Department, Al Razi Hospital, Shuwaikh, Kuwait.
    Study Design: Retrospective, descriptive study.

    Objective: To describe the epidemiological profile of patients with spinal cord injury (SCI) in Kuwait.

    Setting: Physical Medicine and Rehabilitation Hospital, Kuwait. Read More

    Prolapsed ureterocele in an adult woman after endoscopic incision.
    Urol Ann 2018 Jan-Mar;10(1):100-102
    Department of Surgery, Urology OU, Civil Hospital of Guastalla, AUSL of Reggio Emilia, Guastalla 42016 (RE), Italy.
    A 44-year-old woman underwent endoscopic incision of a right simple ureterocele with hydronephrosis discovered during gynecological assessment for stress urinary incontinence with Stage I cystocele. At the postoperative visits, she has reported a persistent flap of mucosa coming out from her urethra protruding in the vagina despite manual reduction. An endoscopic resection of the mucosa flap was programmed. Read More

    Occipital lobe infarction: a rare presentation of bilateral giant cavernous carotid aneurysms: a case report.
    BMC Ophthalmol 2018 Feb 2;18(1):25. Epub 2018 Feb 2.
    Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.
    Background: Cavernous carotid aneurysm (CCA) represents 2-9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bilateral CCAs account for 11-29% of patients and are commonly associated with structural weaknesses in the ICA wall, secondary to systemic hypertension. CCAs are considered benign lesions, given the low risk for developing major neurologic morbidities (i. Read More

    Dexmedetomidine-based monitored conscious sedation combined local anesthesia for levator resection in a 10-year-old child with Marcus Gunn jaw-winking synkinesis: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9369
    Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
    Rationale: Levator resection has become a routine procedure for patients with severe Marcus Gunn jaw-winking synkinesis (MGJWS). To optimize the surgical outcome, adult patients need to be kept awake, or easily aroused and responsive to verbal commands during the operation. However, levator resection is commonly performed under general anesthesia in pediatric patients. Read More

    Ptosis induced by topical steroid eye drops: Two cases reports.
    Medicine (Baltimore) 2017 Dec;96(51):e9288
    Eye Center, 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.
    Rationale: Ptosis is a rare complication of periocular steroid use. Studies report that local injections of steroids produce ptosis. We describe the first 2 cases of ptosis because of long-term treatment with topical steroid eye drops. Read More

    Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: A case report and literature review.
    Medicine (Baltimore) 2017 Dec;96(50):e9262
    Department of Neurology.
    Rationale: Immune checkpoint inhibitors have led to the development of new approaches for cancer treatment with positive outcomes. However, checkpoint blockade is associated with a unique spectrum of immune-related adverse events (irAEs), which may cause irreversible neurological deficits and even death.

    Patient Concerns: We presented a case of a 57-year-old man with non-small-cell lung cancer. Read More

    Primary vaginal squamous cell carcinoma with bladder involvement in uterine prolapsed patient: Case report.
    Medicine (Baltimore) 2017 Dec;96(50):e8993
    Institute of Obstetrics and Emergency Medicine, Medical Faculty, University of Rzeszow, Rzeszow, Poland.
    Rationale: Primary vaginal squamous cell carcinoma (SCC) is a rare disease. Primary SCC in prolapsed vagina is extremely rare. In the presented case additional bladder involvement was found. Read More

    [Association of polymorphism of 1800255 COL3A1 gene with pelvic organ prolapse and urinary incontinence in women: preliminary data].
    Urologiia 2017 Dec(6):30-33
    Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
    Relevance: Collagen type I and III have a significant role in the development of pelvic organ prolapse (POP) and urinary incontinence in women. The role of the COL3A1 gene polymorphism remains debatable. Some studies and meta-analyzes have found a direct correlation between genetic defects and POP, while other researchers have not confirmed this association. Read More

    [Multiple Resections for Metastases from Colorectal Cancer].
    Gan To Kagaku Ryoho 2018 Jan;45(1):100-102
    Dept. of Surgery, Tokyo Women's Medical University Medical Center East.
    Purpose: We analyzed to clarify an outcome of multiple resections of metastases from colorectal cancer.

    Patients And Method: Total 7 cases who underwent several resections for metastases from colorectal cancer in Saiseikai Kurihashi Hospital after 2010 were enrolled for analysis.

    Result: Age of patients at the time of the primary site resection was 67(45-78)year-old, including 4males and 3 females. Read More

    Invited Commentary: Evaluation of Horner Syndrome in the MRI Era.
    J Neuroophthalmol 2018 Mar;38(1):52-53
    Department of Neuro-Ophthalmology, University of Lausanne, Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland.
    This Invited Commentary discusses the following article: BACKGROUND:: To identify the etiologies of adult Horner syndrome (HS) in the MRI era using a targeted evaluation approach and to assess the value and yield of targeted imaging.

    Methods: A retrospective chart review was performed of 200 adult outpatients with HS, confirmed with cocaine eyedrop testing. Patients were divided into subgroups based on the presence or absence of symptoms and those who did or did not receive additional testing with hydroxyamphetamine drops. Read More

    [A modified implant for upper eyelid ptosis correction in frontalis suspension surgery].
    Vestn Oftalmol 2017;133(6):69-75
    Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogriazskaya St., Moscow, Russian Federation, 105062.
    Aim: to develop a modified implant to correct ptosis through brow suspension and to evaluate its effectiveness.

    Material And Methods: The clinical group consisted of 20 patients (29 eyes) aged 23 to 69 years (45±5.3 years on the average) and the comparison group - of 20 patients (33 eyes) aged 19 to 77 years (47±9. Read More

    Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease.
    PLoS One 2018 9;13(1):e0188617. Epub 2018 Jan 9.
    Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America.
    Canine myxomatous mitral valve disease (MMVD) resembles the early stages of myxomatous pathology seen in human non-syndromic mitral valve prolapse, a common valvular heart disease in the adult human population. Canine MMVD is seen in older subjects, suggesting age-related epigenetic dysregulation leading to derangements in valvular cell populations and matrix synthesis or degradation. We hypothesized that valvular interstitial cells (VICs) undergo disease-relevant changes in miRNA expression. Read More

    Preparation of laminin/nidogen adsorbed urinary bladder decellularized materials via a mussel-inspired polydopamine coating for pelvic reconstruction.
    Am J Transl Res 2017 15;9(12):5289-5298. Epub 2017 Dec 15.
    Key Laboratory of Pig Industry Sciences, Ministry of AgricultureChongqing, China.
    Pelvic organ prolapse (POP) is a serious health issue that affects many adult women. A common strategy for POP reconstruction is to use scaffold materials to reconstruct the prolapsed pelvic organ. However, the existing materials for pelvic reconstruction do not meet the clinical requirements for biocompatibility, mechanics and immunological rejection. Read More

    Horner syndrome as a postoperative complication after minimally invasive video-assisted thyroidectomy: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8888
    Department of Endocrinology.
    Rationale: Horner syndrome is an unusual complication after thyroidectomy.

    Patient Concerns: We report a case of Horner syndrome in a 34-year-old female patient with Graves disease associated with papillary thyroid carcinoma who underwent left-side minimally invasive video-assisted thyroidectomy and neck dissection.

    Diagnosis: Horner syndrome was diagnosed based on left myosis, eyelid ptosis, and mild enophthalmos, which developed in the patient on postoperative day 2. Read More

    Mitochondrial mutations in 12S rRNA and 16S rRNA presenting as chronic progressive external ophthalmoplegia (CPEO) plus: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8869
    Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong, People's Republic of China.
    Rationale: Chronic progressive external ophthalmoplegia (CPEO) is a classical mitochondrial ocular disorder characterized by bilateral progressive ptosis and ophthalmoplegia. Kearns -Sayre syndrome (KSS) is a multisystem disorder with PEO, cardiac conduction block, and pigmentary retinopathy. A few individuals with CPEO have other manifestations of KSS, but do not meet all the clinical diagnosis criteria, and this is called "CPEO plus. Read More

    Cardiac arrest and ventricular arrhythmia in adults with Ebstein anomaly and left ventricular non-compaction.
    J Cardiol 2018 May 2;71(5):484-487. Epub 2018 Jan 2.
    Institute of Cardiology, Department of Congenital Heart Disease, Warsaw, Poland.
    Background: Ebstein anomaly is a complex, congenital heart defect that is associated with a variety of cardiac abnormalities. Studies found a similar sarcomere gene mutation in patients with Ebstein anomaly (EA) and patients with isolated left ventricular non-compaction (LVNC).

    Aim: We aimed to show the prevalence of LVNC and its potential relationship with severe cardiac events (VT - ventricular tachycardia, cardiac arrest) in adult patients with EA. Read More

    Extending knowledge of the clinical picture of Balkan adder (Vipera berus bosniensis) envenoming: The first photographically-documented neurotoxic case from South-Western Hungary.
    Toxicon 2018 Mar 2;143:29-35. Epub 2018 Jan 2.
    "Moritz Kaposi" General Hospital, Department of Surgery, Tallián Gyula u. 20-32, H-7400 Kaposvár, Hungary.
    We report a severe envenoming associated with minimal local symptoms following a Balkan adder (Vipera berus bosniensis) bite in South-Western Hungary. A 63-year-old male with a history of hypertension and sinus bradycardia (45/min) was bitten by a sub-adult specimen of V. b. Read More

    Comprehension of Pelvic Organ Prolapse and Urinary Incontinence in Southern Appalachian Women.
    South Med J 2018 01;111(1):18-22
    From the Departments of Obstetrics/Gynecology and Family Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City.
    Objectives: Despite their growing prevalence, pelvic floor disorders (PFDs) remain undertreated and not well understood by patients, with treatment disparities noted in specific subgroups of women. The goal of the present study was to determine the basic understanding of PFDs of women in the southern Appalachian region of the United States, to determine factors that predict knowledge, and to explore the possible disparities in seeking access to care among women in this region who reported symptoms.

    Methods: A survey of patient knowledge of PFDs, specifically urinary incontinence (UI) and pelvic organ prolapse (POP), was conducted in Johnson City, Tennessee, and involved 305 female patients from this city and the surrounding region. Read More

    [A case of myasthenia-like symptoms induced by cibenzoline overdosage].
    Rinsho Shinkeigaku 2018 Jan 22;58(1):41-44. Epub 2017 Dec 22.
    Department of Neurology, Kumamoto Saishunso National Hospital.
    The present patient was an 87-year-old man who had been taking cibenzoline for tachyarrhythmia. Five years after initiation of administration, he was referred to our hospital for ptosis that worsened from midday, as well as weakness of the facial and limb muscles. He tested negative for anti-acetylcholine receptor antibody but positive in the edrophonium test, suggesting that he had myasthenia gravis. Read More

    The Effect of Screen-to-Screen Versus Face-to-Face Consultation on Doctor-Patient Communication: An Experimental Study with Simulated Patients.
    J Med Internet Res 2017 Dec 20;19(12):e421. Epub 2017 Dec 20.
    Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, Netherlands.
    Background: Despite the emergence of Web-based patient-provider contact, it is still unclear how the quality of Web-based doctor-patient interactions differs from face-to-face interactions.

    Objective: This study aimed to examine (1) the impact of a consultation medium on doctors' and patients' communicative behavior in terms of information exchange, interpersonal relationship building, and shared decision making and (2) the mediating role of doctors' and patients' communicative behavior on satisfaction with both types of consultation medium.

    Methods: Doctor-patient consultations on pelvic organ prolapse were simulated, both in a face-to-face and in a screen-to-screen (video) setting. Read More

    Pelvic Organ Prolapse in a Fighter Pilot with Alpha-1 Antitrypsin Deficiency.
    Aerosp Med Hum Perform 2018 Jan;89(1):66-69
    Background: Few researchers have studied symptomatic younger to middle-aged women with pelvic organ prolapse. The association between highly strenuous activity and prolapse symptoms is largely theoretical. It is also known that a genetic component likely contributes to early-onset pelvic organ prolapse, but prevention and treatment with respect to this has not been explored. Read More

    Two-Year Results of Burch Compared With Midurethral Sling With Sacrocolpopexy: A Randomized Controlled Trial.
    Obstet Gynecol 2018 Jan;131(1):31-38
    Divisions of Gynecologic Surgery and Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota; and the Department of Obstetrics and Gynecology, University of Missouri, Kansas City, Missouri.
    Objective: To evaluate 1- and 2-year urinary continence rates after Burch retropubic urethropexy compared with a retropubic midurethral sling for women with urinary incontinence undergoing sacrocolpopexy.

    Methods: We conducted a planned secondary analysis of a multicenter, randomized, single-blind trial comparing Burch with a sling that enrolled participants from June 2009 to August 2013. Objective outcome measures of continence were assessed at 1- and 2-year follow-up through office visits and validated questionnaires. Read More

    Liposomal Bupivacaine During Robotic Colpopexy and Posterior Repair: A Randomized Controlled Trial.
    Obstet Gynecol 2018 Jan;131(1):39-46
    Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, TriHealth Good Samaritan Hospital, Cincinnati, Ohio.
    Objective: To evaluate the effect of liposomal bupivacaine on postoperative pain among patients undergoing robotic sacrocolpopexy with posterior repair.

    Methods: This was a randomized, patient-blinded, placebo-controlled trial of women undergoing robotic sacrocolpopexy with posterior repair. Liposomal bupivacaine or normal saline placebo was injected into laparoscopic and vaginal incisions at completion of surgery. Read More

    Clinical features of visual disturbances secondary to isolated sphenoid sinus inflammatory diseases.
    BMC Ophthalmol 2017 Dec 6;17(1):237. Epub 2017 Dec 6.
    Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
    Background: Visual disturbances associated with isolated sphenoid sinus inflammatory diseases (ISSIDs) are easily misdiagnosed due to the nonspecific symptoms and undetectable anatomical location. The main objective of this retrospective case series is to investigate the clinical features of visual disturbances secondary to ISSIDs.

    Methods: Clinical data of 23 patients with unilateral or bilateral visual disturbances secondary to ISSIDs from 2004 to 2014 with new symptoms were collected. Read More

    [Surgical treatment of purulent corneal ulcers in eyes with neurotrophic keratitis and paralytic lagophthalmos].
    Vestn Oftalmol 2017;133(5):32-37
    Research Institute of Eye Diseases, 11A, B, Rossolimo St., Moscow, Russian Federation, 119021.
    Aim: to develop a surgical approach to the treatment of purulent corneal ulcer in eyes with neurotrophic keratitis with lagophthalmos after auditory neuroma removal or stroke.

    Material And Methods: A total of 12 patients (13 eyes) have been managed. All received combined surgery that included simultaneous keratoplasty, autoconjunctivoplasty, and permanent partial tarsorrhaphy. Read More

    Botulinum toxin for treating unilateral apraxia of eyelid opening in a patient with congenital myotonia.
    Arq Bras Oftalmol 2017 Sep-Oct;80(5):330-331
    Department of Ophthalmology, Rio Hortega University Hospital, Dulzaina St, Valladolid, Spain.
    A 37-year-old female presented with severe apraxia of lid opening (ALO) affecting the right upper lid associated with Becker congenital myotonia (MC). The patient had a history of right upper lid ptosis for 25 years that was exacerbated over the previous month with severe incapacity to open her right eye. No other associated neurological or ophthalmic symptoms were observed. Read More

    Umbilical Cord Prolapse in a Labouring Patient: A Multidisciplinary and Interprofessional Simulation Scenario.
    Cureus 2017 Sep 16;9(9):e1692. Epub 2017 Sep 16.
    Department of Innovation in Medical Education, University of Ottawa.
    This case is one of an eight-case multidisciplinary curriculum designed and implemented at the University of Ottawa by simulation educators with specialty training in obstetrics and gynecology (OB/GYN) and anesthesiology. Consultation from a nurse educator maintained quality and relevance of objectives for nursing participants. The curriculum was prepared to train OB/GYN and anesthesiology residents and nurses to hone crisis resource management skills and to recognize and manage rare/critical medical events in an obstetrical setting. Read More

    New onset of myasthenia gravis after intravesical Bacillus Calmette-Guerin: A case report and literature review.
    Medicine (Baltimore) 2017 Nov;96(46):e8757
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
    Rationale: Recently, drug-related myasthenia gravis (MG) has received attention, because the number of reported cases involving MG associated with immune checkpoint inhibitors, a new immunotherapy, is increasing. We present a case involving the new onset of MG, in which the symptoms started shortly after intravesical Bacillus Calmette-Guerin (BCG) for bladder cancer.

    Patient Concerns: A 69-year-old male with bladder cancer developed ptosis and diplopia 4 days after the completion of a treatment regimen with intravesical BCG weekly for 6 weeks. Read More

    Ptosis as the only manifestation of diabetic superior division oculomotor nerve palsy: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8739
    aDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University bDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung cPhD Program in Translational Medicine, Kaohsiung Medical University and Academia Sinica dDepartment of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Rationale: Diabetic oculomotor nerve palsies, also called ischemic third nerve palsies, are the most common etiologic subset of oculomotor nerve palsy in adults. Diabetic oculomotor nerve palsies typically present with ptosis and diplopia, but pupillary function is often spared. The oculomotor nerve separates into superior division and inferior division, with the superior division innervating the superior rectus and levator palpebrae superioris. Read More

    Is the distance from punctum a factor in the anatomical and functional success of canalicular laceration repairs?
    Indian J Ophthalmol 2017 Nov;65(11):1114-1119
    Department of Ophthalmology, Sankara Eye Hospital, Ludhiana, Punjab, India.
    Purpose: The aim is to analyze the influence of the location of lacrimal canalicular laceration over the eventual anatomical and functional success after surgery.

    Methods: Retrospective, observational study of proximal canalicular laceration (PCL) and distal canalicular laceration (DCL) repairs by a single surgeon (MS). The distance between lacrimal punctum and the lateral canalicular lacerated end was defined as proximal (<6 mm) and distal (≥6 mm). Read More

    Therapeutic Plasma Exchange in a rare case myasthenic crisis after Botox injection.
    Atheroscler Suppl 2017 Nov 31;30:283-285. Epub 2017 May 31.
    Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Hemmat Highway, Tehran, Iran. Electronic address:
    Background And Aims: Botulinum toxin (Botox) injections are used as a cosmetic treatment to decrease wrinkles in face and chin. Being a neurotoxic agent it minimizes muscle activity, while side effects are usually rare. This article subsequently presents one case of these rare effects. Read More

    Post-Coital Acute Rupture of a Fenestrated Aortic Valve.
    J Heart Valve Dis 2017 05;26(3):358-360
    Cardiovascular Surgery Department, University Hospital of Lausanne, Lausanne, Switzerland.
    Fenestrated aortic valve is a frequent condition which is, for most of the time, asymptomatic and generally has no influence on aortic valve competence. However, aortic valve regurgitation could occur, especially in the case of fibrous strand rupture. In this situation, acute aortic regurgitation is poorly tolerated and requires urgent surgical correction. Read More

    Bileaflet Foldoplasty in Barlow’s Disease.
    J Heart Valve Dis 2017 05;26(3):355-357
    Banner University Medical Center - Tucson, Tucson, AZ, USA.
    Mitral valve repair is a feasible and preferable option for the treatment of Barlow's disease. Complex valve repair techniques, in contrast, often lead to increased cross-clamp times and low cardiac output syndrome. A simple, fast, and reproducible foldoplasty technique to reduce anterior and posterior mitral leaflet heights may improve coaptation and reduce mitral regurgitation. Read More

    No. 351-Transvaginal Mesh Procedures for Pelvic Organ Prolapse.
    J Obstet Gynaecol Can 2017 Nov;39(11):1085-1097
    Montréal, QC.
    Objective: This guideline reviews the evidence related to the risks and benefits of using transvaginal mesh in pelvic organ prolapse repairs in order to update recommendations initially made in 2011.

    Intended Users: Gynaecologists, residents, urologists, urogynaecologists, and other health care providers who assess, counsel, and care for women with pelvic organ prolapse.

    Target Population: Adult women with symptomatic pelvic organ prolapse considering surgery and those who have previously undergone transvaginal mesh procedures for the treatment of pelvic organ prolapse. Read More

    Perioperative Behavioral Therapy and Pelvic Muscle Strengthening Do Not Enhance Quality of Life After Pelvic Surgery: Secondary Report of a Randomized Controlled Trial.
    Phys Ther 2017 Nov;97(11):1075-1083
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Gynecologic Health and Disease Branch, Bethesda, Maryland.
    Background: There is significant need for trials evaluating the long-term effectiveness of a rigorous program of perioperative behavioral therapy with pelvic floor muscle training (BPMT) in women undergoing transvaginal reconstructive surgery for prolapse.

    Objective: The purpose of this study was to evaluate the effect of perioperative BPMT on health-related quality of life (HRQOL) and sexual function following vaginal surgery for pelvic organ prolapse (POP) and stress urinary incontinence (SUI).

    Design: This study is a secondary report of a 2 × 2 factorial randomized controlled trial. Read More

    Effective and rapid treatment of wound botulism, a case report.
    BMC Surg 2017 Oct 26;17(1):103. Epub 2017 Oct 26.
    Chirurgische Universitäts- und Poliklinik, BG-Klinikum Bergmannsheil GmbH, Universitätsklinikum der Ruhr-Universität, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
    Background: The latest news shows several cases of contaminated heroin that is found in different parts all over Europe. This information can be helpful for the emergency doctors to find the correct diagnosis of wound botulism in patients who are intravenous drug users.

    Case Presentation: We describe a case of a 40-year-old man who presented to the emergency department in 2016. Read More

    Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement.
    Ophthal Plast Reconstr Surg 2018 Jan/Feb;34(1):e27-e29
    Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Aichi, Japan.
    A 69-year-old Japanese male presented with a 3-month history of bilateral ptosis with lacrimal gland bulge. He came from western Japan, an area endemic for human T-lymphotropic virus Type 1 infection. Physical examination and imaging revealed bilaterally enlarged lacrimal glands. Read More

    Aromatase Inhibitors Are Associated With Low Sexual Desire Causing Distress and Fecal Incontinence in Women: An Observational Study.
    J Sex Med 2017 Dec 21;14(12):1566-1574. Epub 2017 Oct 21.
    Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. Electronic address:
    Background: Little is known of the impact of aromatase inhibitor (AI) therapy on sexual and pelvic floor function.

    Aim: To document the prevalence of, and factors associated with, low desire, sexually related personal distress, hypoactive sexual desire dysfunction (HSDD), and pelvic floor dysfunction in women 10 years after breast cancer diagnosis.

    Methods: This was a prospective, observational, community-based cohort study of Australian women with invasive breast cancer recruited within 12 months of diagnosis. Read More

    Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients.
    Invest Ophthalmol Vis Sci 2017 10;58(12):5452-5459
    Department of Ophthalmology, Ninth People's Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Purpose: To evaluate the prognosis in Chinese patients with conjunctival melanoma and determine its predictors. Further, to explore the racial differences in clinical characteristics and outcomes between Chinese and Caucasian patients.

    Methods: This cohort study included 57 eyes of 57 consecutive patients with pathologically verified conjunctival melanoma between 1996 and 2016. Read More

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