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    Surgical Treatment of Recurrent Rectal Prolapse in an Adult Female Black-crested Mangabey () by Colopexy.
    Comp Med 2018 Feb;68(1):80-83
    Chicago Zoological Society, Brookfield Zoo, Brookfield, Illinois.
    A 13-y-old, multiparous female black-crested mangabey (Lophocebus aterrimus) underwent surgical treatment for chronically recurring rectal prolapse by laparotomy and subsequent colopexy. Initially, a laparoscopic approach was attempted but was converted to an open approach after intraabdominal adhesions were noted. The colopexy was performed through a ventral midline incision, with no complications intraoperatively or postoperatively. Read More

    Epidemiological profile of spinal cord injuries at a tertiary rehabilitation center in Kuwait.
    Spinal Cord Ser Cases 2018 22;4. Epub 2018 Jan 22.
    Physical Medicine and Rehabilitation Department, Al Razi Hospital, Shuwaikh, Kuwait.
    Study Design: Retrospective, descriptive study.

    Objective: To describe the epidemiological profile of patients with spinal cord injury (SCI) in Kuwait.

    Setting: Physical Medicine and Rehabilitation Hospital, Kuwait. Read More

    Prolapsed ureterocele in an adult woman after endoscopic incision.
    Urol Ann 2018 Jan-Mar;10(1):100-102
    Department of Surgery, Urology OU, Civil Hospital of Guastalla, AUSL of Reggio Emilia, Guastalla 42016 (RE), Italy.
    A 44-year-old woman underwent endoscopic incision of a right simple ureterocele with hydronephrosis discovered during gynecological assessment for stress urinary incontinence with Stage I cystocele. At the postoperative visits, she has reported a persistent flap of mucosa coming out from her urethra protruding in the vagina despite manual reduction. An endoscopic resection of the mucosa flap was programmed. Read More

    Occipital lobe infarction: a rare presentation of bilateral giant cavernous carotid aneurysms: a case report.
    BMC Ophthalmol 2018 Feb 2;18(1):25. Epub 2018 Feb 2.
    Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.
    Background: Cavernous carotid aneurysm (CCA) represents 2-9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bilateral CCAs account for 11-29% of patients and are commonly associated with structural weaknesses in the ICA wall, secondary to systemic hypertension. CCAs are considered benign lesions, given the low risk for developing major neurologic morbidities (i. Read More

    Dexmedetomidine-based monitored conscious sedation combined local anesthesia for levator resection in a 10-year-old child with Marcus Gunn jaw-winking synkinesis: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9369
    Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
    Rationale: Levator resection has become a routine procedure for patients with severe Marcus Gunn jaw-winking synkinesis (MGJWS). To optimize the surgical outcome, adult patients need to be kept awake, or easily aroused and responsive to verbal commands during the operation. However, levator resection is commonly performed under general anesthesia in pediatric patients. Read More

    Ptosis induced by topical steroid eye drops: Two cases reports.
    Medicine (Baltimore) 2017 Dec;96(51):e9288
    Eye Center, 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.
    Rationale: Ptosis is a rare complication of periocular steroid use. Studies report that local injections of steroids produce ptosis. We describe the first 2 cases of ptosis because of long-term treatment with topical steroid eye drops. Read More

    Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: A case report and literature review.
    Medicine (Baltimore) 2017 Dec;96(50):e9262
    Department of Neurology.
    Rationale: Immune checkpoint inhibitors have led to the development of new approaches for cancer treatment with positive outcomes. However, checkpoint blockade is associated with a unique spectrum of immune-related adverse events (irAEs), which may cause irreversible neurological deficits and even death.

    Patient Concerns: We presented a case of a 57-year-old man with non-small-cell lung cancer. Read More

    Primary vaginal squamous cell carcinoma with bladder involvement in uterine prolapsed patient: Case report.
    Medicine (Baltimore) 2017 Dec;96(50):e8993
    Institute of Obstetrics and Emergency Medicine, Medical Faculty, University of Rzeszow, Rzeszow, Poland.
    Rationale: Primary vaginal squamous cell carcinoma (SCC) is a rare disease. Primary SCC in prolapsed vagina is extremely rare. In the presented case additional bladder involvement was found. Read More

    Invited Commentary: Evaluation of Horner Syndrome in the MRI Era.
    J Neuroophthalmol 2018 Mar;38(1):52-53
    Department of Neuro-Ophthalmology, University of Lausanne, Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland.
    This Invited Commentary discusses the following article: BACKGROUND:: To identify the etiologies of adult Horner syndrome (HS) in the MRI era using a targeted evaluation approach and to assess the value and yield of targeted imaging.

    Methods: A retrospective chart review was performed of 200 adult outpatients with HS, confirmed with cocaine eyedrop testing. Patients were divided into subgroups based on the presence or absence of symptoms and those who did or did not receive additional testing with hydroxyamphetamine drops. Read More

    Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease.
    PLoS One 2018 9;13(1):e0188617. Epub 2018 Jan 9.
    Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America.
    Canine myxomatous mitral valve disease (MMVD) resembles the early stages of myxomatous pathology seen in human non-syndromic mitral valve prolapse, a common valvular heart disease in the adult human population. Canine MMVD is seen in older subjects, suggesting age-related epigenetic dysregulation leading to derangements in valvular cell populations and matrix synthesis or degradation. We hypothesized that valvular interstitial cells (VICs) undergo disease-relevant changes in miRNA expression. Read More

    Preparation of laminin/nidogen adsorbed urinary bladder decellularized materials via a mussel-inspired polydopamine coating for pelvic reconstruction.
    Am J Transl Res 2017 15;9(12):5289-5298. Epub 2017 Dec 15.
    Key Laboratory of Pig Industry Sciences, Ministry of AgricultureChongqing, China.
    Pelvic organ prolapse (POP) is a serious health issue that affects many adult women. A common strategy for POP reconstruction is to use scaffold materials to reconstruct the prolapsed pelvic organ. However, the existing materials for pelvic reconstruction do not meet the clinical requirements for biocompatibility, mechanics and immunological rejection. Read More

    Horner syndrome as a postoperative complication after minimally invasive video-assisted thyroidectomy: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8888
    Department of Endocrinology.
    Rationale: Horner syndrome is an unusual complication after thyroidectomy.

    Patient Concerns: We report a case of Horner syndrome in a 34-year-old female patient with Graves disease associated with papillary thyroid carcinoma who underwent left-side minimally invasive video-assisted thyroidectomy and neck dissection.

    Diagnosis: Horner syndrome was diagnosed based on left myosis, eyelid ptosis, and mild enophthalmos, which developed in the patient on postoperative day 2. Read More

    Mitochondrial mutations in 12S rRNA and 16S rRNA presenting as chronic progressive external ophthalmoplegia (CPEO) plus: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8869
    Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong, People's Republic of China.
    Rationale: Chronic progressive external ophthalmoplegia (CPEO) is a classical mitochondrial ocular disorder characterized by bilateral progressive ptosis and ophthalmoplegia. Kearns -Sayre syndrome (KSS) is a multisystem disorder with PEO, cardiac conduction block, and pigmentary retinopathy. A few individuals with CPEO have other manifestations of KSS, but do not meet all the clinical diagnosis criteria, and this is called "CPEO plus. Read More

    Cardiac arrest and ventricular arrhythmia in adults with Ebstein anomaly and left ventricular non-compaction.
    J Cardiol 2018 Jan 2. Epub 2018 Jan 2.
    Institute of Cardiology, Department of Congenital Heart Disease, Warsaw, Poland.
    Background: Ebstein anomaly is a complex, congenital heart defect that is associated with a variety of cardiac abnormalities. Studies found a similar sarcomere gene mutation in patients with Ebstein anomaly (EA) and patients with isolated left ventricular non-compaction (LVNC).

    Aim: We aimed to show the prevalence of LVNC and its potential relationship with severe cardiac events (VT - ventricular tachycardia, cardiac arrest) in adult patients with EA. Read More

    Extending knowledge of the clinical picture of Balkan adder (Vipera berus bosniensis) envenoming: The first photographically-documented neurotoxic case from South-Western Hungary.
    Toxicon 2018 Mar 2;143:29-35. Epub 2018 Jan 2.
    "Moritz Kaposi" General Hospital, Department of Surgery, Tallián Gyula u. 20-32, H-7400 Kaposvár, Hungary.
    We report a severe envenoming associated with minimal local symptoms following a Balkan adder (Vipera berus bosniensis) bite in South-Western Hungary. A 63-year-old male with a history of hypertension and sinus bradycardia (45/min) was bitten by a sub-adult specimen of V. b. Read More

    Outcome reporting for surgical treatment of degenerative mitral valve disease: a systematic review and critical appraisal.
    Interact Cardiovasc Thorac Surg 2017 Dec 8. Epub 2017 Dec 8.
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands.
    Objectives: Standardized outcome reporting is of critical importance for performance monitoring, improvement of existing techniques and introduction of novel technologies. Whether outcome reporting for surgical treatment of degenerative mitral valve disease complies with the guidelines has not been assessed to date.

    Methods: A systematic review of PubMed, EMBASE, Web of Science and the Cochrane Library was conducted for articles published between 1 January 2009 and 7 March 2016. Read More

    Two-Year Results of Burch Compared With Midurethral Sling With Sacrocolpopexy: A Randomized Controlled Trial.
    Obstet Gynecol 2018 Jan;131(1):31-38
    Divisions of Gynecologic Surgery and Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota; and the Department of Obstetrics and Gynecology, University of Missouri, Kansas City, Missouri.
    Objective: To evaluate 1- and 2-year urinary continence rates after Burch retropubic urethropexy compared with a retropubic midurethral sling for women with urinary incontinence undergoing sacrocolpopexy.

    Methods: We conducted a planned secondary analysis of a multicenter, randomized, single-blind trial comparing Burch with a sling that enrolled participants from June 2009 to August 2013. Objective outcome measures of continence were assessed at 1- and 2-year follow-up through office visits and validated questionnaires. Read More

    Liposomal Bupivacaine During Robotic Colpopexy and Posterior Repair: A Randomized Controlled Trial.
    Obstet Gynecol 2018 Jan;131(1):39-46
    Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, TriHealth Good Samaritan Hospital, Cincinnati, Ohio.
    Objective: To evaluate the effect of liposomal bupivacaine on postoperative pain among patients undergoing robotic sacrocolpopexy with posterior repair.

    Methods: This was a randomized, patient-blinded, placebo-controlled trial of women undergoing robotic sacrocolpopexy with posterior repair. Liposomal bupivacaine or normal saline placebo was injected into laparoscopic and vaginal incisions at completion of surgery. Read More

    Clinical features of visual disturbances secondary to isolated sphenoid sinus inflammatory diseases.
    BMC Ophthalmol 2017 Dec 6;17(1):237. Epub 2017 Dec 6.
    Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
    Background: Visual disturbances associated with isolated sphenoid sinus inflammatory diseases (ISSIDs) are easily misdiagnosed due to the nonspecific symptoms and undetectable anatomical location. The main objective of this retrospective case series is to investigate the clinical features of visual disturbances secondary to ISSIDs.

    Methods: Clinical data of 23 patients with unilateral or bilateral visual disturbances secondary to ISSIDs from 2004 to 2014 with new symptoms were collected. Read More

    Botulinum toxin for treating unilateral apraxia of eyelid opening in a patient with congenital myotonia.
    Arq Bras Oftalmol 2017 Sep-Oct;80(5):330-331
    Department of Ophthalmology, Rio Hortega University Hospital, Dulzaina St, Valladolid, Spain.
    A 37-year-old female presented with severe apraxia of lid opening (ALO) affecting the right upper lid associated with Becker congenital myotonia (MC). The patient had a history of right upper lid ptosis for 25 years that was exacerbated over the previous month with severe incapacity to open her right eye. No other associated neurological or ophthalmic symptoms were observed. Read More

    Umbilical Cord Prolapse in a Labouring Patient: A Multidisciplinary and Interprofessional Simulation Scenario.
    Cureus 2017 Sep 16;9(9):e1692. Epub 2017 Sep 16.
    Department of Innovation in Medical Education, University of Ottawa.
    This case is one of an eight-case multidisciplinary curriculum designed and implemented at the University of Ottawa by simulation educators with specialty training in obstetrics and gynecology (OB/GYN) and anesthesiology. Consultation from a nurse educator maintained quality and relevance of objectives for nursing participants. The curriculum was prepared to train OB/GYN and anesthesiology residents and nurses to hone crisis resource management skills and to recognize and manage rare/critical medical events in an obstetrical setting. Read More

    New onset of myasthenia gravis after intravesical Bacillus Calmette-Guerin: A case report and literature review.
    Medicine (Baltimore) 2017 Nov;96(46):e8757
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
    Rationale: Recently, drug-related myasthenia gravis (MG) has received attention, because the number of reported cases involving MG associated with immune checkpoint inhibitors, a new immunotherapy, is increasing. We present a case involving the new onset of MG, in which the symptoms started shortly after intravesical Bacillus Calmette-Guerin (BCG) for bladder cancer.

    Patient Concerns: A 69-year-old male with bladder cancer developed ptosis and diplopia 4 days after the completion of a treatment regimen with intravesical BCG weekly for 6 weeks. Read More

    Ptosis as the only manifestation of diabetic superior division oculomotor nerve palsy: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8739
    aDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University bDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung cPhD Program in Translational Medicine, Kaohsiung Medical University and Academia Sinica dDepartment of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Rationale: Diabetic oculomotor nerve palsies, also called ischemic third nerve palsies, are the most common etiologic subset of oculomotor nerve palsy in adults. Diabetic oculomotor nerve palsies typically present with ptosis and diplopia, but pupillary function is often spared. The oculomotor nerve separates into superior division and inferior division, with the superior division innervating the superior rectus and levator palpebrae superioris. Read More

    Is the distance from punctum a factor in the anatomical and functional success of canalicular laceration repairs?
    Indian J Ophthalmol 2017 Nov;65(11):1114-1119
    Department of Ophthalmology, Sankara Eye Hospital, Ludhiana, Punjab, India.
    Purpose: The aim is to analyze the influence of the location of lacrimal canalicular laceration over the eventual anatomical and functional success after surgery.

    Methods: Retrospective, observational study of proximal canalicular laceration (PCL) and distal canalicular laceration (DCL) repairs by a single surgeon (MS). The distance between lacrimal punctum and the lateral canalicular lacerated end was defined as proximal (<6 mm) and distal (≥6 mm). Read More

    Therapeutic Plasma Exchange in a rare case myasthenic crisis after Botox injection.
    Atheroscler Suppl 2017 Nov 31;30:283-285. Epub 2017 May 31.
    Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Hemmat Highway, Tehran, Iran. Electronic address:
    Background And Aims: Botulinum toxin (Botox) injections are used as a cosmetic treatment to decrease wrinkles in face and chin. Being a neurotoxic agent it minimizes muscle activity, while side effects are usually rare. This article subsequently presents one case of these rare effects. Read More

    No. 351-Transvaginal Mesh Procedures for Pelvic Organ Prolapse.
    J Obstet Gynaecol Can 2017 Nov;39(11):1085-1097
    Montréal, QC.
    Objective: This guideline reviews the evidence related to the risks and benefits of using transvaginal mesh in pelvic organ prolapse repairs in order to update recommendations initially made in 2011.

    Intended Users: Gynaecologists, residents, urologists, urogynaecologists, and other health care providers who assess, counsel, and care for women with pelvic organ prolapse.

    Target Population: Adult women with symptomatic pelvic organ prolapse considering surgery and those who have previously undergone transvaginal mesh procedures for the treatment of pelvic organ prolapse. Read More

    Perioperative Behavioral Therapy and Pelvic Muscle Strengthening Do Not Enhance Quality of Life After Pelvic Surgery: Secondary Report of a Randomized Controlled Trial.
    Phys Ther 2017 Nov;97(11):1075-1083
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Gynecologic Health and Disease Branch, Bethesda, Maryland.
    Background: There is significant need for trials evaluating the long-term effectiveness of a rigorous program of perioperative behavioral therapy with pelvic floor muscle training (BPMT) in women undergoing transvaginal reconstructive surgery for prolapse.

    Objective: The purpose of this study was to evaluate the effect of perioperative BPMT on health-related quality of life (HRQOL) and sexual function following vaginal surgery for pelvic organ prolapse (POP) and stress urinary incontinence (SUI).

    Design: This study is a secondary report of a 2 × 2 factorial randomized controlled trial. Read More

    Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement.
    Ophthal Plast Reconstr Surg 2018 Jan/Feb;34(1):e27-e29
    Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Aichi, Japan.
    A 69-year-old Japanese male presented with a 3-month history of bilateral ptosis with lacrimal gland bulge. He came from western Japan, an area endemic for human T-lymphotropic virus Type 1 infection. Physical examination and imaging revealed bilaterally enlarged lacrimal glands. Read More

    Aromatase Inhibitors Are Associated With Low Sexual Desire Causing Distress and Fecal Incontinence in Women: An Observational Study.
    J Sex Med 2017 Dec 21;14(12):1566-1574. Epub 2017 Oct 21.
    Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. Electronic address:
    Background: Little is known of the impact of aromatase inhibitor (AI) therapy on sexual and pelvic floor function.

    Aim: To document the prevalence of, and factors associated with, low desire, sexually related personal distress, hypoactive sexual desire dysfunction (HSDD), and pelvic floor dysfunction in women 10 years after breast cancer diagnosis.

    Methods: This was a prospective, observational, community-based cohort study of Australian women with invasive breast cancer recruited within 12 months of diagnosis. Read More

    Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients.
    Invest Ophthalmol Vis Sci 2017 Oct;58(12):5452-5459
    Department of Ophthalmology, Ninth People's Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Purpose: To evaluate the prognosis in Chinese patients with conjunctival melanoma and determine its predictors. Further, to explore the racial differences in clinical characteristics and outcomes between Chinese and Caucasian patients.

    Methods: This cohort study included 57 eyes of 57 consecutive patients with pathologically verified conjunctival melanoma between 1996 and 2016. Read More

    Perineal colostomy prolapse: a novel application of mesh sacral pexy.
    Ann R Coll Surg Engl 2018 Jan 19;100(1):e7-e9. Epub 2017 Oct 19.
    Louvain University Medical School , Brussels , Belgium.
    Full thickness colonic prolapse following pseudocontinent perineal colostomy has not been previously reported. Possible contributing factors include a large skin aperture at the site of the perineal stoma, the absence of anal sphincters and mesorectal attachments and the presence of a perineal hernia. A novel application of sacral pexy combined with perineal hernia repair using two prosthetic meshes is described. Read More

    Contralateral eye surgery with adjustable suture for management of third nerve palsy with aberrant regeneration.
    Indian J Ophthalmol 2017 Oct;65(10):1058-1061
    Department of Pediatric Ophthalmology and Strabismus, Dr. Shroff's Charity Eye Hospital, New Delhi, India.
    Aberrant regeneration of the third nerve following its palsy is commonly seen after trauma and compressive lesions. This phenomenon is thought to result due to misdirection of the regenerating axons. Surgical management is a great challenge in the third nerve palsy owing to multiple muscle involvement and is often accompanied by ptosis and poor Bell's phenomenon. Read More

    Female-to-Male Gender Affirming Top Surgery: A Single Surgeon's 15-Year Retrospective Review and Treatment Algorithm.
    Aesthet Surg J 2017 Dec;38(1):49-57
    Private practice, Mississauga, Ontario, Canada.
    Background: Mastectomy, referred to here as "Top Surgery," is an important surgical step for female-to-male (FTM) transgender patients. The goal is to excise breast tissue and create a masculine chest contour. Despite the rising demand for Top Surgery, debate still exists regarding how to select the most appropriate surgical technique to optimize aesthetic outcomes safely. Read More

    Fatigable ptosis as an initial presentation of adult-onset Leigh syndrome.
    Neurology 2017 Oct;89(16):1754
    From the Departments of Neurology (E.H.O., S.-H.C., J.-W.C., J.-H.C.) and Radiology (S.K.B.), Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital; and Department of Neurology (S.-Y.C., K.-D.C.), Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.

    In-Office Sutureless Correction of Prolapsed Subconjunctival Orbital Fat.
    Ophthal Plast Reconstr Surg 2018 Jan/Feb;34(1):79-81
    Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY, U.S.A.
    Purpose: To describe a minimally invasive, sutureless, small incision surgical technique for the treatment of subconjunctival orbital fat prolapse (SOFP) performed using local anesthesia in an office setting.

    Methods: Retrospective study of the surgical outcome of 45 patients with either bilateral or unilateral SOFP treated by a single surgeon (R.S. Read More

    Acute intractable headache and oculomotor nerve palsy associated with nicorandil: A case report.
    Am J Emerg Med 2017 Dec 5;35(12):1988.e3-1988.e5. Epub 2017 Oct 5.
    Department of Emergency Medicine, Department of Medicine, Chungbuk National University, Cheongju, Republic of Korea. Electronic address:
    Acute non-traumatic headaches with neurological deficits alarm emergency department (ED) physicians. Typically, a sudden headache with oculomotor nerve palsy involving a pupil indicates the possibility of a subarachnoid hemorrhage (SAH) due to an aneurysm originating from the posterior communicating artery. For the ED physician, thinking beyond the possibility of an SAH can be crucial. Read More

    Does a missed obstetric anal sphincter injury at time of delivery affect short-term functional outcome?
    Ann R Coll Surg Engl 2018 Jan 15;100(1):26-32. Epub 2017 Sep 15.
    Department of Surgery and Cancer, Chelsea and Westminster Hospital, Imperial College London NHS Trust , London , UK.
    Introduction This study aimed to ascertain whether missed obstetric anal sphincter injury at delivery had worse functional and quality of life outcomes than primary repair immediately following delivery. Materials and methods Two to one propensity matching was undertaken of patients presenting to a tertiary pelvic floor unit with ultrasound evidence of missed obstetric anal sphincter injury within 24 months of delivery with patients who underwent primary repair at the time of delivery by parity, grade of injury and time to assessment. Outcomes compared included Birmingham Bowel, Bladder and Urinary Symptom Questionnaire (BBUSQ), Wexner Incontinence Score, Short Form-36, Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire and anorectal physiology results. Read More

    A Gartner Duct Cyst Masquerading as Anterior Vaginal Prolapse.
    Obstet Gynecol 2017 Nov;130(5):1039-1041
    Cleveland Clinic, Cleveland, Ohio; and Duke University, Durham, North Carolina.
    Background: Gartner duct cysts are embryologic remnants of the mesonephric ducts that may present as a vaginal mass or cyst.

    Case: A patient was referred for surgical management of prolapse whose bulging anterior vagina was actually a Gartner duct cyst that required excision as a result of symptoms. Preoperative magnetic resonance imaging helped confirm the diagnosis. Read More

    Heritability of Mitral Regurgitation: Observations From the Framingham Heart Study and Swedish Population.
    Circ Cardiovasc Genet 2017 Oct;10(5)
    From the Boston University's and National Heart, Lung and Blood Institute's Framingham Heart Study, MA (F.N.D., B.T.L., E.W.O., P.S., E.J.B., R.S.V.); Cardiovascular Division, Department of Medicine, University of California San Francisco (F.N.D.); Center for Primary Health Care Research, Lund University, Malmö, Sweden (X.L., B.Z., K.S.); Department of Biostatistics (S.L., Q.Y., V.X.), Department of Epidemiology (V.X., E.J.B., R.S.V.), and Cardiology and Preventive Medicine Sections, Department of Medicine (E.J.B., R.S.V.), Boston University School of Medicine, MA; Department of Cardiology, Clinical Sciences, Lund University, Sweden (A.M., P.A., J.G.S.); and Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.).
    Background: Familial aggregation has been described for primary mitral regurgitation (MR) caused by mitral valve prolapse. We hypothesized that heritability of MR exists across different MR subtypes including nonprimary MR.

    Methods And Results: Study participants were FHS (Framingham Heart Study) Generation 3 (Gen 3) and Gen 2 cohort participants and all adult Swedish siblings born after 1932 identified in 1997 and followed through 2010. Read More

    Robot-Assisted Ventral Mesh Rectopexy for Rectal Prolapse: A 5-Year Experience at a Tertiary Referral Center.
    Dis Colon Rectum 2017 Nov;60(11):1215-1223
    1 Department of Surgery, Meander Medical Centre, Amersfoort, the Netherlands 2 Faculty of Science and Technology, Institute of Technical Medicine, Twente University, Enschede, the Netherlands.
    Background: Laparoscopic ventral mesh rectopexy is being increasingly performed internationally to treat rectal prolapse syndromes. Robotic assistance appears advantageous for this procedure, but literature regarding robot-assisted ventral mesh rectopexy is limited.

    Objective: The primary objective of this study was to assess the safety and effectiveness of robot-assisted ventral mesh rectopexy in the largest consecutive series of patients to date. Read More

    Validity of utility measures for women with pelvic organ prolapse.
    Am J Obstet Gynecol 2018 01 6;218(1):119.e1-119.e8. Epub 2017 Oct 6.
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
    Background: Pelvic organ prolapse is a common condition that frequently coexists with urinary and fecal incontinence. The impact of prolapse on quality of life is typically measured through condition-specific quality-of-life instruments. Utility preference scores are a standardized generic health-related quality-of-life measure that summarizes morbidity on a scale from 0 (death) to 1 (optimum health). Read More

    Anti-Ma2-associated limbic encephalitis with coexisting chronic inflammatory demyelinating polyneuropathy in a patient with non-Hodgkin lymphoma: A case report.
    Medicine (Baltimore) 2017 Oct;96(40):e8228
    aDepartment of Neurology bDepartment of Orthopedic Trauma, the First Hospital of Jilin University, Changchun, Jilin, China.
    Rationale: We report the rare case of a 74-year-old man with anti-Ma2-associated paraneoplastic neurologic syndrome (PNS), and review and analyze the clinical manifestations, diagnosis, and treatment of the disease.

    Patient Concerns: The patient presented with a 5-month history of muscle weakness, progressive body aches, and weakness and numbness in both lower extremities. Before his hospitalization, he had experienced cognitive function decline; ptosis, inward gaze, and vertical gaze palsy in the right eye; and occasional visual hallucinations. Read More

    Isolated aortic root dilation in homocystinuria.
    J Inherit Metab Dis 2018 Jan 4;41(1):109-115. Epub 2017 Oct 4.
    Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
    Background: Vascular complications in homocystinuria have been known for many years, but there have been no reports to date on involvement of the ascending aorta.

    Methods: We conducted a cross-sectional study of patients with homocystinuria, known to a single metabolic centre, and evaluated in 2016 with a transthoracic echocardiogram. Aortic root dilation was defined as Z-score ≥ 2. Read More

    Pathological findings in explanted vaginal mesh.
    Hum Pathol 2017 11 29;69:46-54. Epub 2017 Sep 29.
    Department of Pathology, Shandong University, School of Medicine, Jinan, Shandong, 250012, PR China; Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, 85724, USA; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390, TX. Electronic address:
    In light of the legal issues and the shortage of data on histopathological findings, we summarized our experience on how explanted vaginal mesh specimens were managed in a surgical pathology practice during the last 5 years. Clinical history and pathology reports were collected from 155 women undergoing transvaginal tape excision. The degree of chronic inflammation, fibrosis, foreign-body giant cell reactions, the number of capillary vessels and nerve fibers, and the presence or absence of adipose tissue were recorded. Read More

    Diskogenic Reactivation of Herpes Zoster.
    World Neurosurg 2018 Jan 27;109:138-139. Epub 2017 Sep 27.
    Department of Neurosurgery, St. Vincent's Hospital, Melbourne, Australia; Centre for Clinical Neuroscience and Neurological Research, Melbourne, Australia; Department of Surgery, University of Melbourne, Melbourne, Australia.
    Varicella zoster virus remains dormant in the dorsal root ganglia after childhood exposure to chickenpox. Its reactivation results in herpes zoster, otherwise known as shingles, which is a painful vesicular rash in a dermatomal distribution. We present a case of foraminal disk extrusion that resulted in radicular pain in a dermatomal distribution. Read More

    Surgical management of female pelvic organ prolapse with and without urinary incontinence: A single center experience.
    Medicine (Baltimore) 2017 Sep;96(39):e7914
    Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.
    The study reports a single center experience with surgical management of female pelvic organ prolapse (POP) with and without urinary incontinence.Between January 2006 and July 2016, 93 consecutive patients with anterior and/or apical symptomatic POP underwent abdominal sacrocolpopexy (ASC) or laparoscopic sacrocolpopexy (LSC) or pubovaginal cystocele sling (PCS); 25 patients had concomitant stress urinary incontinence (SUI). Subjective outcome was assessed by the Pelvic Floor Impact Questionnaire (short form) (PFIQ-7) investigating bladder, bowel and vaginal functions, sexual activity, and daily life. Read More

    Association of Vulvar Symptoms With Pelvic Organ Prolapse and Urinary Incontinence.
    J Low Genit Tract Dis 2017 Oct;21(4):315-318
    1Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA; and 2Partners in Obstetrics and Gynecology, Waterloo, IA.
    Objective: The aim of this study was to compare vulvar symptoms between urogynecology patients diagnosed with urinary incontinence (UI) and/or pelvic organ prolapse to women presenting for annual gynecological care.

    Methods: This is a retrospective cross-sectional study. Vulvar symptoms (burning, pain, itching, dyspareunia, and discharge) were measured by asking respondents to rate the severity of each symptom from 0 (none) to 10 (most severe). Read More

    Prolapse recurrence following sacrocolpopexy vs uterosacral ligament suspension: a comparison stratified by Pelvic Organ Prolapse Quantification stage.
    Am J Obstet Gynecol 2018 01 23;218(1):116.e1-116.e5. Epub 2017 Sep 23.
    St Francis Hospital and Medical Center, Hartford, CT.
    Background: Insufficient evidence evaluates which pelvic organ prolapse surgery is best suited to an individual woman based on the stage of her prolapse.

    Objective: We sought to compare prolapse recurrence rates following sacrocolpopexy and uterosacral ligament suspension after stratifying by preoperative Pelvic Organ Prolapse Quantification stage.

    Study Design: We compared all women who underwent minimally invasive sacrocolpopexy or vaginal or minimally invasive uterosacral ligament suspension from 2009 through 2015 at a large academic center. Read More

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