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    Umbilical Cord Prolapse in a Labouring Patient: A Multidisciplinary and Interprofessional Simulation Scenario.
    Cureus 2017 Sep 16;9(9):e1692. Epub 2017 Sep 16.
    Department of Innovation in Medical Education, University of Ottawa.
    This case is one of an eight-case multidisciplinary curriculum designed and implemented at the University of Ottawa by simulation educators with specialty training in obstetrics and gynecology (OB/GYN) and anesthesiology. Consultation from a nurse educator maintained quality and relevance of objectives for nursing participants. The curriculum was prepared to train OB/GYN and anesthesiology residents and nurses to hone crisis resource management skills and to recognize and manage rare/critical medical events in an obstetrical setting. Read More

    No. 351-Transvaginal Mesh Procedures for Pelvic Organ Prolapse.
    J Obstet Gynaecol Can 2017 Nov;39(11):1085-1097
    Montréal, QC.
    Objective: This guideline reviews the evidence related to the risks and benefits of using transvaginal mesh in pelvic organ prolapse repairs in order to update recommendations initially made in 2011.

    Intended Users: Gynaecologists, residents, urologists, urogynaecologists, and other health care providers who assess, counsel, and care for women with pelvic organ prolapse.

    Target Population: Adult women with symptomatic pelvic organ prolapse considering surgery and those who have previously undergone transvaginal mesh procedures for the treatment of pelvic organ prolapse. Read More

    Perioperative Behavioral Therapy and Pelvic Muscle Strengthening Do Not Enhance Quality of Life After Pelvic Surgery: Secondary Report of a Randomized Controlled Trial.
    Phys Ther 2017 Nov;97(11):1075-1083
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Gynecologic Health and Disease Branch, Bethesda, Maryland.
    Background: There is significant need for trials evaluating the long-term effectiveness of a rigorous program of perioperative behavioral therapy with pelvic floor muscle training (BPMT) in women undergoing transvaginal reconstructive surgery for prolapse.

    Objective: The purpose of this study was to evaluate the effect of perioperative BPMT on health-related quality of life (HRQOL) and sexual function following vaginal surgery for pelvic organ prolapse (POP) and stress urinary incontinence (SUI).

    Design: This study is a secondary report of a 2 × 2 factorial randomized controlled trial. Read More

    Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement.
    Ophthal Plast Reconstr Surg 2017 Oct 20. Epub 2017 Oct 20.
    Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Aichi, Japan.
    A 69-year-old Japanese male presented with a 3-month history of bilateral ptosis with lacrimal gland bulge. He came from western Japan, an area endemic for human T-lymphotropic virus Type 1 infection. Physical examination and imaging revealed bilaterally enlarged lacrimal glands. Read More

    Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients.
    Invest Ophthalmol Vis Sci 2017 Oct;58(12):5452-5459
    Department of Ophthalmology, Ninth People's Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Purpose: To evaluate the prognosis in Chinese patients with conjunctival melanoma and determine its predictors. Further, to explore the racial differences in clinical characteristics and outcomes between Chinese and Caucasian patients.

    Methods: This cohort study included 57 eyes of 57 consecutive patients with pathologically verified conjunctival melanoma between 1996 and 2016. Read More

    Fatigable ptosis as an initial presentation of adult-onset Leigh syndrome.
    Neurology 2017 Oct;89(16):1754
    From the Departments of Neurology (E.H.O., S.-H.C., J.-W.C., J.-H.C.) and Radiology (S.K.B.), Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital; and Department of Neurology (S.-Y.C., K.-D.C.), Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.

    A Gartner Duct Cyst Masquerading as Anterior Vaginal Prolapse.
    Obstet Gynecol 2017 Nov;130(5):1039-1041
    Cleveland Clinic, Cleveland, Ohio; and Duke University, Durham, North Carolina.
    Background: Gartner duct cysts are embryologic remnants of the mesonephric ducts that may present as a vaginal mass or cyst.

    Case: A patient was referred for surgical management of prolapse whose bulging anterior vagina was actually a Gartner duct cyst that required excision as a result of symptoms. Preoperative magnetic resonance imaging helped confirm the diagnosis. Read More

    Heritability of Mitral Regurgitation: Observations From the Framingham Heart Study and Swedish Population.
    Circ Cardiovasc Genet 2017 Oct;10(5)
    From the Boston University's and National Heart, Lung and Blood Institute's Framingham Heart Study, MA (F.N.D., B.T.L., E.W.O., P.S., E.J.B., R.S.V.); Cardiovascular Division, Department of Medicine, University of California San Francisco (F.N.D.); Center for Primary Health Care Research, Lund University, Malmö, Sweden (X.L., B.Z., K.S.); Department of Biostatistics (S.L., Q.Y., V.X.), Department of Epidemiology (V.X., E.J.B., R.S.V.), and Cardiology and Preventive Medicine Sections, Department of Medicine (E.J.B., R.S.V.), Boston University School of Medicine, MA; Department of Cardiology, Clinical Sciences, Lund University, Sweden (A.M., P.A., J.G.S.); and Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.).
    Background: Familial aggregation has been described for primary mitral regurgitation (MR) caused by mitral valve prolapse. We hypothesized that heritability of MR exists across different MR subtypes including nonprimary MR.

    Methods And Results: Study participants were FHS (Framingham Heart Study) Generation 3 (Gen 3) and Gen 2 cohort participants and all adult Swedish siblings born after 1932 identified in 1997 and followed through 2010. Read More

    Robot-Assisted Ventral Mesh Rectopexy for Rectal Prolapse: A 5-Year Experience at a Tertiary Referral Center.
    Dis Colon Rectum 2017 Nov;60(11):1215-1223
    1 Department of Surgery, Meander Medical Centre, Amersfoort, the Netherlands 2 Faculty of Science and Technology, Institute of Technical Medicine, Twente University, Enschede, the Netherlands.
    Background: Laparoscopic ventral mesh rectopexy is being increasingly performed internationally to treat rectal prolapse syndromes. Robotic assistance appears advantageous for this procedure, but literature regarding robot-assisted ventral mesh rectopexy is limited.

    Objective: The primary objective of this study was to assess the safety and effectiveness of robot-assisted ventral mesh rectopexy in the largest consecutive series of patients to date. Read More

    Anti-Ma2-associated limbic encephalitis with coexisting chronic inflammatory demyelinating polyneuropathy in a patient with non-Hodgkin lymphoma: A case report.
    Medicine (Baltimore) 2017 Oct;96(40):e8228
    aDepartment of Neurology bDepartment of Orthopedic Trauma, the First Hospital of Jilin University, Changchun, Jilin, China.
    Rationale: We report the rare case of a 74-year-old man with anti-Ma2-associated paraneoplastic neurologic syndrome (PNS), and review and analyze the clinical manifestations, diagnosis, and treatment of the disease.

    Patient Concerns: The patient presented with a 5-month history of muscle weakness, progressive body aches, and weakness and numbness in both lower extremities. Before his hospitalization, he had experienced cognitive function decline; ptosis, inward gaze, and vertical gaze palsy in the right eye; and occasional visual hallucinations. Read More

    Isolated aortic root dilation in homocystinuria.
    J Inherit Metab Dis 2017 Oct 4. Epub 2017 Oct 4.
    Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
    Background: Vascular complications in homocystinuria have been known for many years, but there have been no reports to date on involvement of the ascending aorta.

    Methods: We conducted a cross-sectional study of patients with homocystinuria, known to a single metabolic centre, and evaluated in 2016 with a transthoracic echocardiogram. Aortic root dilation was defined as Z-score ≥ 2. Read More

    Surgical management of female pelvic organ prolapse with and without urinary incontinence: A single center experience.
    Medicine (Baltimore) 2017 Sep;96(39):e7914
    Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.
    The study reports a single center experience with surgical management of female pelvic organ prolapse (POP) with and without urinary incontinence.Between January 2006 and July 2016, 93 consecutive patients with anterior and/or apical symptomatic POP underwent abdominal sacrocolpopexy (ASC) or laparoscopic sacrocolpopexy (LSC) or pubovaginal cystocele sling (PCS); 25 patients had concomitant stress urinary incontinence (SUI). Subjective outcome was assessed by the Pelvic Floor Impact Questionnaire (short form) (PFIQ-7) investigating bladder, bowel and vaginal functions, sexual activity, and daily life. Read More

    Recurrent Painful Ophthalmoplegic Neuropathy with Residual Mydriasis in an Adult: Should it Be Classified as Ophthalmoplegic Migraine?
    Intern Med 2017 Oct 15;56(20):2769-2772. Epub 2017 Sep 15.
    Komoro Kosei General Hospital, Japan.
    Recurrent painful ophthalmoplegic neuropathy (RPON) is a rare condition that manifests as headache and ophthalmoplegia. It typically occurs in children. Although migraine or neuropathy have been suggested as etiologies, the precise etiology remains unclear. Read More

    Expanding the Phenotypic and Genotypic Landscape of Autoimmune Polyendocrine Syndrome Type 1.
    J Clin Endocrinol Metab 2017 Sep;102(9):3546-3556
    Department of Clinical Science, University of Bergen, Bergen 5020, Norway.
    Context: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare monogenic autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene and characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and primary adrenal insufficiency. Comprehensive characterizations of large patient cohorts are rare.

    Objective: To perform an extensive clinical, immunological, and genetic characterization of a large nationwide Russian APS-1 cohort. Read More

    Aetiology of acquired blepharoptosis in young adults.
    Orbit 2017 Sep 6:1-6. Epub 2017 Sep 6.
    a Royal Victorian Eye and Ear Hospital , East Melbourne , Victoria , Australia.
    Purpose: To identify the causes of blepharoptosis in young adults, and explore cases that do not fit into current diagnostic categories.

    Methods: A retrospective cohort study of all patients aged 18-40 years ("young adults") with acquired blepharoptosis that presented to two specialist ocular plastics practices and a paediatric ophthalmologist over a period of up to 25 years. Each patient was classified according to diagnosis. Read More

    Expression of Mitochondrial Respiratory Chain Complexes in the Vaginal Wall in Postmenopausal Women with Pelvic Organ Prolapse.
    Gynecol Obstet Invest 2017 Aug 30. Epub 2017 Aug 30.
    Clinical Department of Gynecology and Obstetrics, Split University Hospital, Split, Croatia.
    Background/aims: Pelvic organ prolapse (POP) is a common disease affecting adult women. It is a result of the vaginal wall disorder as well as damage of the supportive structures contributing to the integrity of the pelvic floor. Mitochondrial disorders may have an important role in the vaginal wall degeneration leading to POP. Read More

    Surgical Indications and Outcomes of Mastectomy in Transmen: A Prospective Study of Technical and Self-Reported Measures.
    Plast Reconstr Surg 2017 Sep;140(3):415e-424e
    Amsterdam, The Netherlands From the Department of Plastic, Reconstructive, and Hand Surgery and the Department of Medical Psychology, Center of Expertise on Gender Dysphoria, VU University Medical Center.
    Background: Although transgender surgery constitutes a growing field within plastic surgery, prospective studies on masculinizing mastectomies are lacking. The objectives of the present study were to prospectively follow a cohort of transmen undergoing mastectomy to assess technical and self-reported outcomes and to evaluate surgical decision-making.

    Methods: Fifty-four transmen were recruited during a 10-month period at the Department of Plastic Surgery of the Centre of Expertise on Gender Dysphoria. Read More

    Transabdominal Breast Augmentation: A Review of 114 Cases Performed over 14 Years.
    Plast Reconstr Surg 2017 Sep;140(3):476-487
    Providence, R.I. From the Division of Plastic Surgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University.
    Background: Abdominoplasty patients are frequently candidates for breast rejuvenation as well. Transabdominal breast augmentation permits insertion of breast implants through the abdominoplasty incision. This combined procedure is preferentially performed in an outpatient setting under monitored anesthesia care and nerve blocks. Read More

    Adult Orbital and Adnexal Xanthogranulomatous Disease.
    Asia Pac J Ophthalmol (Phila) 2017 Sep-Oct;6(5):435-443. Epub 2017 Aug 22.
    Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
    Purpose: Adult xanthogranulomatous disease of the orbit and ocular adnexa is a rare disease that can cause serious morbidity and mortality. Ophthalmologists are commonly the first clinicians to come in contact with affected patients and an understanding of the clinical features is essential.

    Design: We present a retrospective case series of patients seen in the oculoplastic unit of a large tertiary referral hospital over a 20-year period. Read More

    A severed IP ligament as a cause for trans-vaginal uterine bleeding post termination of pregnancy: a case report.
    Pan Afr Med J 2017 7;27:95. Epub 2017 Jun 7.
    Royal Hospital for Women, Department of Obstetrics and Gynaecology, Randwick, Australia.
    Uterine perforation is an uncommon yet serious complication of surgical management of first and second trimester termination of pregnancies. The rate of uterine perforation is under reported, as patients are usually asymptomatic. Although uncommon, uterine perforation can cause life-threatening complications for some patients. Read More

    Hedrocele Associated With Full-Thickness Rectal Prolapse: A Very Rare Condition Treated by Ambulatory Laparoscopic Anterior Rectopexy.
    Dis Colon Rectum 2017 Sep;60(9):992-993
    1 Colorectal Unit, Department of Surgery, Michallon University Hospital, Grenoble, France 2 University Grenoble Alps, UMR 5525, CNRS, TIMC-IMAG, Grenoble, France 3 Ambulatory Unit, Department of Surgery, Michallon University Hospital, Grenoble, France.

    The role of GPX1 in the pathogenesis of female pelvic organ prolapse.
    PLoS One 2017 7;12(8):e0181896. Epub 2017 Aug 7.
    Department of Obstetrics and Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
    Gestation and delivery can increase intra-abdominal pressure, which are well-known risk factors for Pelvic Organ Prolapse (POP). But the pathogenesis mechanism of POP remains unclear. Our previous research showed that the expression of glutathione peroxidase type 1 (GPX1) decreased in pelvic floor ligaments from POP patients, implying that oxidative stress (OS) may be related to POP. Read More

    Anterior vaginal repair for urinary incontinence in women.
    Cochrane Database Syst Rev 2017 07 31;7:CD001755. Epub 2017 Jul 31.
    Health Services Research Unit, University of Aberdeen, 3rd Floor, Health Sciences Building, Foresterhill, Aberdeen, Scotland, UK, AB25 2ZD.
    Background: Anterior vaginal repair (anterior colporrhaphy) is an operation traditionally used for moderate or severe stress urinary incontinence (SUI) in women. About a third of adult women experience urinary incontinence. SUI imposes significant health and economic burden to the society and the women affected. Read More

    Conjunctival lymphoma during pregnancy: a case report.
    BMC Ophthalmol 2017 Jul 27;17(1):131. Epub 2017 Jul 27.
    Department of Ophthalmology, Chang Gung Memorial Hospital and University, #5, Fu-Hsing Street, Kweishan, Taoyuan, 333, Taiwan.
    Background: To present a case of conjunctival lymphoma in a young woman complicated by pregnancy.

    Case Presentation: A 38-year-old previously healthy woman presented with a 2-year history of progressive right blepharoptosis. Giant papillomatous sessile masses were identified in the upper and lower fornix bilaterally and involved the tarsus of the right upper lid. Read More

    Complications Following Enucleations and Subsequent Oculoplastic Surgeries.
    Ophthal Plast Reconstr Surg 2017 Jul 26. Epub 2017 Jul 26.
    *The Rotterdam Eye Hospital, Rotterdam; †Erasmus University Medical Centre, Rotterdam; ‡St. Antonius Hospital, Nieuwegein; and §Medisch Centrum Alkmaar, The Netherlands.
    Purpose: To analyze the complications and subsequent type and frequency of oculoplastic surgeries after enucleation in adult patients.

    Methods: The authors conducted a retrospective case note review of adult patients who underwent enucleation followed by placement of an alloplastic implant wrapped in donor sclera between 2001 and 2013. The data collected included patient demographics, surgical indication, implant size, postoperative complications, and subsequent oculoplastic surgical procedures. Read More

    Laparoscopic sacrocolpopexy versus vaginal sacrospinous fixation for vaginal vault prolapse, a randomized controlled trial: SALTO-2 trial, study protocol.
    BMC Womens Health 2017 Jul 26;17(1):52. Epub 2017 Jul 26.
    Department of Obstetrics and Gynaecology, Máxima Medical Centre Veldhoven, De Run, 4600 5500, MB, Veldhoven, The Netherlands.
    Background: Hysterectomy is one of the most performed surgical procedures during lifetime. Almost 10 % of women who have had a hysterectomy because of prolapse symptoms, will visit a gynaecologist for a surgical correction of a vaginal vault prolapse thereafter. Vaginal vault prolapse can be corrected by many different surgical procedures. Read More

    Laparoscopic pectopexy: initial experience of single center with a new technique for apical prolapse surgery.
    Int Braz J Urol 2017 Sep-Oct;43(5):903-909
    Department of Biochemistry, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.
    Objective: To share our first experience with laparoscopic pectopexy, a new technique for apical prolapse surgery, and to evaluate the feasibility of this technique.

    Materials And Methods: Seven patients with apical prolapse underwent surgery with laparoscopic pectopexy. The lateral parts of the iliopectineal ligament were used for a bilateral mesh fixation of the descended structures. Read More

    PREPL deficiency: delineation of the phenotype and development of a functional blood assay.
    Genet Med 2017 Jul 20. Epub 2017 Jul 20.
    Laboratory of Biochemical Neuroendocrinology, Department of Human Genetics, University of Leuven, Leuven, Belgium.
    PurposePREPL deficiency causes neonatal hypotonia, ptosis, neonatal feeding difficulties, childhood obesity, xerostomia, and growth hormone deficiency. Different recessive contiguous gene deletion syndromes involving PREPL and a variable combination of SLC3A1 (hypotonia-cystinuria syndrome), CAMKMT (atypical hypotonia-cystinuria syndrome), and PPM1B (2p21 deletion syndrome) have been described. In isolated PREPL deficiency, previously described only once, the absence of cystinuria complicates the diagnosis. Read More

    Comprehensive comparing percutaneous endoscopic lumbar discectomy with posterior lumbar internal fixation for treatment of adjacent segment lumbar disc prolapse with stable retrolisthesis: A retrospective case-control study.
    Medicine (Baltimore) 2017 Jul;96(29):e7471
    aDepartment of Spine Surgery bDepartment of Pharmacy, the Third Hospital of Hebei Medical University, Shijiazhuang, China.
    The study was to comprehensively compare the postoperative outcome and imaging parameter characters in a short/middle period between the percutaneous endoscopic lumbar discectomy (PELD) and the internal fixation of bone graft fusion (the most common form is posterior lumbar interbody fusion [PLIF]) for the treatment of adjacent segment lumbar disc prolapse with stable retrolisthesis after a previous lumbar internal fixation surgery.In this retrospective case-control study, we collected the medical records from 11 patients who received PELD operation (defined as PELD group) for and from 13 patients who received the internal fixation of bone graft fusion of lumbar posterior vertebral lamina decompression (defined as control group) for the treatment of the lumbar disc prolapse combined with stable retrolisthesis at Department of Spine Surgery, the Third Hospital of Hebei Medical University (Shijiazhuang, China) from May 2010 to December 2015. The operation time, the bleeding volume of perioperation, and the rehabilitation days of postoperation were compared between 2 groups. Read More

    Bungarus multicinctus multicinctus Snakebite in Taiwan.
    Am J Trop Med Hyg 2017 Jun;96(6):1497-1504
    Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
    AbstractAlthough specific antivenom is available in Taiwan, respiratory failure and general pain frequently accompany Bungarus multicinctus envenomation and there have been few reports on the management of B. multicinctus envenomation. We retrospectively analyzed 44 cases of B. Read More

    A retrospective analysis of the effectiveness of anterior pelvic organ prolapse repair with Prolift versus Elevate vaginal mesh.
    Int J Gynaecol Obstet 2017 Nov 23;139(2):192-196. Epub 2017 Aug 23.
    Clínica Universitária de Obstetrícia e Ginecologia, Centro Hospitalar Lisboa Norte - Hospital Universitário de Santa Maria, Lisbon, Portugal.
    Objective: To compare the effectiveness of anterior pelvic organ prolapse (POP) repair using Prolift (Ethicon, Somerville, NJ, USA) or Elevate (American Medical Systems, Minnetonka, MN, USA) vaginal mesh at 12 months of follow-up.

    Methods: A retrospective study was undertaken using the records for the first 50 Prolift procedures in 2007-2009 and the first 50 Elevate procedures in 2013-2015 performed at a tertiary urogynecology unit in Lisbon, Portugal. Postoperative follow-up occurred at 3, 6, and 12 months. Read More

    Utilization of apical vaginal support procedures at time of inpatient hysterectomy performed for benign conditions: a national estimate.
    Am J Obstet Gynecol 2017 Oct 14;217(4):436.e1-436.e8. Epub 2017 Jul 14.
    Obstetrics and Gynecology, Washington University in St Louis, St Louis, MO.
    Background: Apical vaginal support is considered the keystone of pelvic organ support. Level I evidence supports reestablishment of apical support at time of hysterectomy, regardless of whether the hysterectomy is performed for prolapse. National rates of apical support procedure performance at time of inpatient hysterectomy have not been well described. Read More

    Periorbital changes associated with prostaglandin analogs in Korean patients.
    BMC Ophthalmol 2017 Jul 17;17(1):126. Epub 2017 Jul 17.
    Department of Ophthalmology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 896 Pyeongchon-dong, Dongan-gu, Anyang, Gyeonggi-do, 431-070, South Korea.
    Background: Prostaglandin analogs (PGAs) are commonly used to treat glaucoma because of their powerful intraocular pressure lowering effect. However, various periorbital changes associated with the use of PGAs have been reported. We investigated the incidence of periorbital changes in Korean patients who were treated with PGAs, and analyzed clinical factors associated with superior sulcus deepening. Read More

    Anterior lumbar discectomy and fusion for acute cauda equina syndrome caused by recurrent disc prolapse: report of 3 cases.
    J Neurosurg Spine 2017 Oct 14;27(4):352-356. Epub 2017 Jul 14.
    Exeter Spine Unit, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom; and.
    There is a lack of information and consensus regarding the optimal treatment for recurrent disc herniation previously treated by posterior discectomy, and no reports have described an anterior approach for recurrent disc herniation causing cauda equina syndrome (CES). Revision posterior decompression, irrespective of the presence of CES, has been reported to be associated with significantly higher rates of dural tears, hematomas, and iatrogenic nerve root damage. The authors describe treatment and outcomes in 3 consecutive cases of patients who underwent anterior lumbar discectomy and fusion (ALDF) for CES caused by recurrent disc herniations that had been previously treated with posterior discectomy. Read More


    Assessment of Mitral Valve Repair With Exercise Echocardiography: Artificial Chordae vs Leaflet Resection.
    Semin Thorac Cardiovasc Surg 2017 Spring;29(1):25-32. Epub 2017 Jan 10.
    Department of Cardiothoracic Surgery, Skane University Hospital, Lund University, Lund, Sweden.
    Mitral valve (MV) repair with artificial chordae (AC) or leaflet resection (LR) is associated with good hemodynamics at rest. The aim of this study was to compare these techniques in terms of exercise capacity and echocardiographic parameters of hemodynamics at rest and peak exercise. We conducted a study in 2015 of 56 patients, who had undergone surgery for degenerative posterior mitral leaflet prolapse between 2005 and 2014 using either AC (n = 24) or LR (n = 32). Read More

    Nivolumab-induced myasthenia gravis in a patient with squamous cell lung carcinoma: Case report.
    Medicine (Baltimore) 2017 Jul;96(27):e7350
    aDivision of Rheumatology/Immunology/Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center bDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center cDivision of Pulmonary Medicine, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
    Rationale: Nivolumab (Nivo) is an immune checkpoint inhibitor that has been used to treat advanced melanoma, nonsmall cell lung carcinoma, and renal cell carcinoma since 2015. Nivo is associated with several side effects, including hepatitis, pneumonitis, acute renal failure, endocrine disorder, and other immune-related adverse events. Here, we describe the case of a 65-year-old man with squamous cell lung carcinoma who developed myasthenia gravis (MG) after a third Nivo infusion. Read More

    Factors associated with aortic root dilatation after surgically repaired ventricular septal defect.
    Echocardiography 2017 Aug 6;34(8):1203-1209. Epub 2017 Jul 6.
    Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
    Background: Aortic root dilatation (ARD) in congenital heart disease is related to aortic aneurysm, rupture, and dissection. This study aimed to investigate the factors associated with ARD in patients with surgically repaired ventricular septal defect (VSD).

    Methods: This cross-sectional study included 152 patients with surgically repaired VSD. Read More

    Iatrogenic Pelvic Pain: Surgical and Mesh Complications.
    Phys Med Rehabil Clin N Am 2017 Aug 27;28(3):603-619. Epub 2017 May 27.
    Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9110, USA. Electronic address:
    Female stress urinary incontinence and pelvic organ prolapse are prevalent conditions in adult women. Among treatment alternatives, more traditional methods of surgical intervention have been supplanted by synthetic polypropylene mesh kits. However, novel complications with mesh-related exposure, pelvic pain alone or with dyspareunia, and increased incidence of revision surgeries, resulted in 2 FDA warnings on transvaginal mesh use for prolapse repair. Read More

    A case of myasthenia gravis and myositis induced by nivolumab.
    Rinsho Shinkeigaku 2017 07 30;57(7):373-377. Epub 2017 Jul 30.
    Department of Neurology, Saiseikai Central Hospital.
    A 74-year-old woman, who developed advanced colon cancer with focal recurrence, received two courses of a low dose of nivolumab. Five days after the second course she noticed bilateral ptosis. Her symptoms rapidly progressed to generalized manifestations including limb and neck weakness, dyspnea, and myalgia within the following two weeks. Read More

    Cervical cerclage placement decreases local levels of proinflammatory cytokines in patients with cervical insufficiency.
    Am J Obstet Gynecol 2017 Oct 30;217(4):455.e1-455.e8. Epub 2017 Jun 30.
    Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. Electronic address:
    Background: Cervical insufficiency is characterized by premature, progressive dilation and shortening of the cervix during pregnancy. If left unattended, this can lead to the prolapse and rupture of the amniotic membrane, which usually results in midtrimester pregnancy loss or preterm birth. Previous studies have shown that proinflammatory cytokines such as interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor alpha are up-regulated in normal parturition but are also associated with preterm birth. Read More

    Bilateral ptosis as first presentation of cytophagic histiocytic panniculitis: a case report.
    BMC Ophthalmol 2017 Jul 1;17(1):112. Epub 2017 Jul 1.
    Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, China.
    Background: Cytophagic histiocytic panniculitis (CHP) is a rare form of nodular panniculitis that may progress to panniculitis-like T-cell lymphoma. We report a case of CHP that first manifested as bilateral ptosis, which is the first reported case of this presentation.

    Case Presentation: A 25-year-old woman without medical history was referred to the neurology department of our hospital for evaluation of bilateral ptosis. Read More

    The Classification and Prognosis of Periocular Complications Related to Blindness following Cosmetic Filler Injection.
    Plast Reconstr Surg 2017 Jul;140(1):61-64
    Seongnam-si, Gyeonggi-do, Republic of Korea From the Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University.
    Common side effects during hyaluronic acid filler injections are typically mild and reversible, but several reports of blindness have received attention. The present study focused on orbital symptoms combined with blindness, aiming to classify affected patients and predict their disease course and prognosis. From September of 2012 to August of 2015, nine patients with vision loss after filler injection were retrospectively reviewed. Read More

    [Re-treatments of recurrence after pelvic floor repair surgery].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jun;52(6):374-378
    Department of Obstetrics and Gynecology, Fuzhou General Hospital of the Chinese People's Liberation Army, Fuzhou 350025, China.
    Objective: To analyze re-treatments of recurrence after the pelvic floor repair surgery. Methods: The protocol and the effect of re-treatments were investigated by reviewing and analyzing the clinical data of 81 recurrent patients (grade Ⅱ and above), who had received the pelvic floor repair surgery from January 2011 to January 2016. Pelvic organ prolapse quantitation system (POP-Q) and two questionnaires about quality of life [pelvic floor distress inventory-short form 20 (PFDI-20) and pelvic floor impact questionnaire short form (PFIQ-7)] were used to evaluate objective and subjective efficacy, respectively. Read More

    [Prospective cohort study on the outcomes of sacrospinous ligament fixation using conventional instruments in treating stage Ⅲ-Ⅳ pelvic organ prolapse].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jun;52(6):369-373
    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: To evaluate the medium and long term safety and efficacy of sacrospinous ligament fixation (SSLF) performed with conventional instruments in treating stage Ⅲ-Ⅳ pelvic organ prolapse (POP). Methods: A prospective cohort analysis was conducted in the Peking Union Medical College Hospital, between May 2007 and June 2015, enrolling 55 women with stage Ⅲ-Ⅳ POP who intended to receive SSLF. Primary end points were objective success rates using pelvic organ prolapse quantitation system (POP-Q) and subjective satisfaction rates with questionnaires after surgery according to vaginal examination and related questionnaires for all patients who received SSLF eventually. Read More

    [Long-term effectiveness of transvaginal high uterosacral ligament suspension].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jun;52(6):363-368
    Department of Obstetrics and Gynecology, First Affiliated Hospital, General Hospital of People's Liberation Army, Beijing 100048, China.
    Objective: To assess the long-term effectiveness of the transvaginal high uterosacral ligament suspension (HUS) in women suffering from advanced pelvic organ prolapse (POP). Methods: A retrospective review of records identified 118 women who underwent transvaginal HUS with or without additional concomitant anterior and (or) posterior repairs from June 2003 to August 2009 in the First Affiliated Hospital, General Hospital of People's Liberation Army. Of 118 women, 104 women completed the follow-up during study period; these 104 women were analysed. Read More

    Strangulated gastric prolapse through a gastrostomy site requiring emergent partial gastrectomy.
    BMJ Case Rep 2017 Jun 22;2017. Epub 2017 Jun 22.
    Department of Surgery, St Joseph Mercy Ann Arbor, Ann Arbor, Michigan, USA.
    Strangulated gastric prolapse through a percutaneous endoscopic gastrostomy tract is a rare and potentially life-threatening complication that requires surgical intervention. We describe a case of a 74-year-old woman who was debilitated and ventilator-dependent and who presented with acute gastric prolapse with resultant ischaemic necrosis. The patient underwent an emergent exploratory laparotomy, partial gastrectomy, repair of gastrostomy defect and placement of a gastrojejunostomy feeding tube remote to the previous location. Read More

    Postoperative pain and perceptions of recuperation after suture- and mesh-based apical sacrospinous ligament suspension.
    Int J Gynaecol Obstet 2017 Oct 11;139(1):95-99. Epub 2017 Jul 11.
    Division of Urogynecology, NorthShore University Health System, Skokie, IL, USA.
    Objective: To compare the incidence of postoperative pain after suture- or mesh-based sacrospinous ligament suspension (SSLS).

    Methods: In a retrospective study, data were reviewed from patients who underwent suture- or mesh-based SSLS at a center in Skokie, IL, USA, between 2006 and 2011. The primary outcome was self-reported postoperative pain scores (range 0-10) on the day of surgery (day 0) and 1 day later (day 1). Read More

    Transforming Growth Factor Beta-2 Mutations in Barlow's Disease and Aortic Dilatation.
    Ann Thorac Surg 2017 Jul;104(1):e19-e21
    Department of Cardiac Surgery, Central Hospital Bad Berka, Bad Berka, Germany; Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.
    We report on a patient operated on for degenerative myxomatous mitral and tricuspid valve disease (Barlow's disease) and aortic root dilatation. A valve repair operation and the postoperative course were uneventful. Multigenerational genetic analyses revealed two different mutations in the transforming growth factor beta-2 gene in the same patient. Read More

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