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Med Sci (Basel) 2022 Jun 15;10(2). Epub 2022 Jun 15.

Allegheny Health Network, Pittsburgh, PA 15212, USA.

Valvular heart disease is a rapidly growing cause of global cardiovascular morbidity and mortality with diverse and evolving geographic distribution. The prevalence of rheumatic heart disease, the most common valvular heart disease (affecting approximately 41 million people), has been rising in developing nations, likely due to the expansion of the young adult population and the decrease in premature mortality that has resulted from improved access to antibiotics, microbiological testing, and echocardiography. Rheumatic heart disease has also been rising among the impoverished and, often, indigenous populations of developed nations, spurring public health initiatives that are aimed at alleviating healthcare disparities. Read More

Methodist Debakey Cardiovasc J 2022 3;18(3):87-88. Epub 2022 Jun 3.

Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, US.

A 73-year-old male with a history of dilated cardiomyopathy and paroxysmal atrial fibrillation underwent transthoracic echocardiography (TTE) to evaluate for endocarditis due to fever and gram-positive cocci in chains on blood cultures. TTE revealed a 3 × 8 mm mass on the ventricular aspect of the tricuspid valve ( ). Subsequent transesophageal echocardiography (TEE) showed that the mass in question was actually myxomatous degeneration of the tricuspid valve (TV) and redundant chordae with significant valve prolapse. Read More

Adv Gerontol 2022 ;35(2):308-314

I.P.Pavlov First Saint-Petersburg State Medical University, 6-8 L. Tolstoy str., St. Petersburg 197022, Russian Federation, e-mail:

Population aging, increasing in duration of active life dictate to keep the level of health and create conditions for prolongation and preservation of ability to work. An otorhinolaryngologist often has to deal with age-related changes occurring in the nasal cavity and paranasal sinuses. The study of age-related features occurring in the nasal cavity and paranasal sinuses at the level of not only function, but also structures providing maintenance of mucous membrane protective mechanisms, preserving nasal architectonics, becomes a topical issue. Read More

Middle East Afr J Ophthalmol 2021 Oct-Dec;28(4):216-220. Epub 2022 Apr 30.

Centre for Ocular Regeneration, LV Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To present the outcomes of levator plication (levatorpexy) surgery by posterior approach for correction of ptosis of different aetiologies in Indian eyes.

Methods: Retrospective review of clinical notes and clinical photos of consecutive ptosis patients who underwent levatorpexy from January 2017 to September 2018. Surgery was considered successful if the following four criteria were simultaneously met: a postoperative MRD1 of ≥2 mm and ≤4. Read More

Front Genet 2022 31;13:906667. Epub 2022 May 31.

Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Mitochondrial DNA (mtDNA) maintenance disorders embrace a broad range of clinical syndromes distinguished by the evidence of mtDNA depletion and/or deletions in affected tissues. Among the nuclear genes associated with mtDNA maintenance disorders, mutations produce a homogeneous phenotype, with progressive external ophthalmoplegia (PEO), ptosis, limb weakness, cerebellar ataxia, and dysphagia. The encoded enzyme, ribonuclease H1, is involved in mtDNA replication, whose impairment leads to an increase in replication intermediates resulting from mtDNA replication slowdown. Read More

BMC Geriatr 2022 Jun 14;22(1):503. Epub 2022 Jun 14.

Department of Maxillofacial and Oral Surgery, Faculty of Medicine, University of Ljubljana, Hrvatski trg 6, 1000, Ljubljana, Slovenia.

Background: Facial ageing is a result of superficial wrinkling combined with changes to the underlying soft tissues and skeleton. The influence of tooth loss, as a geriatric characteristic, on facial appearance is still poorly explained. The aim was to evaluate the facial characteristics of older adults, correlate these characteristics with the dentition and make comparisons with young adults using a non-invasive 3D methodology. Read More

Sci Rep 2022 Jun 14;12(1):9878. Epub 2022 Jun 14.

Institute for Clinical and Translational Science, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 31674 PFP, Iowa City, IA, 42240, USA.

Determine the prevalence of pelvic floor disorders (PFD) stratified by age, race, body mass index (BMI), and parity in adult women attending family medicine and general internal medicine clinics at an academic health system. The medical records of 25,425 adult women attending primary care clinics were queried using International Classification of Diseases-10th Revision codes (ICD-10 codes) for PFD [urinary incontinence (UI), pelvic organ prolapse (POP), and bowel dysfunction (anal incontinence (AI) and difficult defecation)]. Prevalence and odds ratios were calculated using univariate and multivariate analysis for age, race, BMI, and parity when available. Read More

Ann Neurol 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, 350005, China.

Objective: Oculopharyngodistal myopathy (OPDM) is an adult-onset neuromuscular disease characterized by progressive ptosis, dysarthria, ophthalmoplegia, and distal muscle weakness. Recent studies revealed GGC repeat expansions in 5'-UTR of LRP12, GIPC1, and NOTCH2NLC are associated with OPDM. Despite these advances, around 30% of OPDM patients remain genetically undiagnosed. Read More

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(6):566-572

Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences.

A 55-year-old man presented with vomiting and upper abdominal pain. Two months later, computed tomography revealed jejunal wall thickening and contrast enhancement. Double-balloon endoscopy revealed severe jejunal stenosis and mucosal prolapse. Read More

Med Trop Sante Int 2021 12 11;1(4). Epub 2021 Nov 11.

CHU Yalgado Ouédraogo de Ouagadougou, Unité de formation et de recherches des sciences de la santé, Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.

Introduction: Certain differences in the epidemiological, clinical, paraclinical and evolution profiles of autoimmune myasthenia gravis (AIMG) are increasingly described in patients according to geographic origins. The present study was carried out in order to help characterize the socio-demographic, clinical and paraclinical profile of AIMG in Ouagadougou, Burkina Faso.

Patients And Methods: This was a cross-sectional, descriptive, multicenter, hospital study carried out in Ouagadougou (Burkina Faso), over a period of 5 years 6 months, from March 2015 to September 2019. Read More

Pan Afr Med J 2022 6;42:10. Epub 2022 May 6.

1 Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.

Vaginal cysts are rare, benign, predominantly cystic lesions of the anterior vaginal wall, with a prevalence of 1 in 200 women. Large vaginal cysts can occasionally present as symptomatic genital prolapse; these cases may be challenging to diagnose due to their rare clinical appearance. In symptomatic large vaginal cysts, surgical excision via vaginal approach is the recommended management with good anatomical results and patient satisfaction. Read More

Pan Afr Med J 2022 14;41:206. Epub 2022 Mar 14.

Cardiac Surgery Department, Mohammed VI University of Health Sciences, Casablanca, Morocco.

Cardiac papillary fibroelastoma is a rare, benign tumour, arising from the valvular endocardium, which could lead to life-threatening complications as myocardial ischemia. We report a case of a 54-year-old male patient who presented in the emergency room with an acute coronary syndrome with transient ST segment elevation. After ruling out coronary artery disease by coronarography, we established the diagnosis of papillary fibroelastoma by performing echocardiogram completed by computed tomography angiography. Read More

BMC Ophthalmol 2022 Jun 8;22(1):256. Epub 2022 Jun 8.

Department of Ocular Plastic, Hebei Provincial Key Laboratory of Ophthalmology, Hebei Provincial Eye Institute, Hebei Eye Hospital, Xingtai, 054001, Hebei, China.

Background: To investigate the expression of elastin in the conjoint facial sheath (CFS) in patients with severe unilateral congenital blepharoptosis in different age groups.

Methods: Twenty-seven cases of severe unilateral congenital blepharoptosis (27 eyes) were treated with CFS + LM complex suspension from January 2020 to July 2020. Within that sample, 9 patients were over 18 years old, 9 patients were 13 to 17 years old and 9 patients were 5 to 12 years old. Read More

J Med Case Rep 2022 May 29;16(1):211. Epub 2022 May 29.

Department of Cardiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Background: Hereditary hemorrhagic telangiectasia, also known as Osler-Weber-Rendu disease, induces arteriovenous malformations in visceral organs. Arteriovenous malformations increase the risk of severe infections and are a common complication associated with hemorrhagic telangiectasia. However, cases of endocarditis associated with hemorrhagic telangiectasia are rarely reported. Read More

Aesthet Surg J 2022 May 26. Epub 2022 May 26.

Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Background: Debate exists surrounding the morphological evolution of the submandibular gland (SMG) with aging, and due to the inconclusive influence of patient demographics, there remains hesitancy to incorporate targeted interventions of the SMG into clinical practice.

Objectives: To determine whether SMG ptosis, hypertrophy, or both is the primary etiology behind increased submandibular volume as one ages.

Methods: MRI segmentation was used to calculate the total and inframandibular (IM) volume and height of the SMG. Read More

Bone Joint J 2022 Jun;104-B(6):715-720

Department of Neuroscience, Leeds General Infirmary, Leeds, UK.

Aims: The aim of the study was to determine if there was a direct correlation between the pain and disability experienced by patients and size of their disc prolapse, measured by the disc's cross-sectional area on T2 axial MRI scans.

Methods: Patients were asked to prospectively complete visual analogue scale (VAS) and Oswestry Disability Index (ODI) scores on the day of their MRI scan. All patients with primary disc herniation were included. Read More

Niger J Clin Pract 2022 May;25(5):653-663

Department of Anatomy, College of Medicine, Faculty of Basic Medical Sciences, University of Nigeria, Nsukka, Enugu Campus, Nigeria.

Background: The female breast is a symbol of femininity and aesthetics having a great psychosocial impact on the woman's sense of wellbeing and self-esteem. To optimize satisfaction of patients in cosmetic and reconstructive breast surgeries, there is a need to define the dominant breast size and shape that connotes feminine attractiveness. This necessitates the knowledge of ideal data for normal nulliparous female breast parameters and volume for various body sizes in the particular population, nationality, and race. Read More

Niger J Clin Pract 2022 May;25(5):597-604

Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakır, Turkey.

Background: Treatment of total genital prolapse in elderly patients is still controversial in terms of postoperative objective and subjective results.

Aim: The present study aimed to compare the long-term objective and subjective cure rates of sacrospinous ligament fixation and Le Fort operation for treatment of total genital prolapse.

Patients And Methods: Patients over the age of 60 with stage 3 or 4 pelvic organ prolapse that presented to the Obstetrics and Gynaecology Clinic of the Faculty of Medicine of *** University. Read More

Tech Coloproctol 2022 May 19. Epub 2022 May 19.

Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Background: The effectiveness of laparoscopic ventral mesh rectopexy (LVMR) in patients with defecatory disorders secondary to internal rectal prolapse is poorly evidenced. A UK-based multicenter randomized controlled trial was designed to determine the clinical efficacy of LVMR compared to controls at medium-term follow-up.

Methods: The randomized controlled trial was conducted from March 1, 2015 TO January 31, 2019. Read More

J Med Case Rep 2022 May 17;16(1):210. Epub 2022 May 17.

Obstetrics and Gynecology Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Timely diagnosis of uterine torsion can lead to acceptable maternal and fetal outcomes. This article presents the case of a 42-year-old pregnant woman, diagnosed with a rare 270° uterine torsion, in whom proper management led to good maternal outcomes but, unfortunately, severe prematurity and metabolic acidosis led to neonatal death. Moreover, the mother was clinically suspected for Ehlers-Danlos syndrome. Read More

Obstet Gynecol 2022 May 5;139(5):788-796. Epub 2022 Apr 5.

Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Hartford Hospital, Hartford, Connecticut; and the Department of Obstetrics and Gynecology, Division of Urogynecology and Pelvic Reconstructive Surgery, Perelman School of Medicine, and The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: To assess the cost effectiveness of performing routine concurrent apical support procedures at the time of hysterectomy for benign indications.

Methods: We developed a Markov decision model from the health care sector perspective to compare concurrent apical support (ie, McCall culdoplasty) at the time of hysterectomy for benign indications compared with hysterectomy alone. We modeled Markov transitions between asymptomatic, prolapse without treatment, and treated prolapse states for 3 years. Read More

Int J Environ Res Public Health 2022 05 5;19(9). Epub 2022 May 5.

Department of Obstetrics and Gynecology, Peking University People's Hospital, No. 11, Xi-Zhi-Men South Street, Xi Cheng District, Beijing 100044, China.

Introduction: The incidence of urinary incontinence (UI) increases with age. Mild and moderate UI have little impact on women and are easily ignored. This study reports the characteristics of non-severe UI and quality of life (QOL) in elderly women using data from a Development and Evaluation of a Senile UI Alert System study. Read More

Biomater Sci 2022 Jun 14;10(12):3110-3121. Epub 2022 Jun 14.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Pelvic organ prolapse (POP) harms the quality of life of elderly patients. Transvaginal polypropylene mesh repair for POP was a frequently reported complication and was banned by the FDA in 2019. New therapeutic strategies are urgently required, and tissue engineering technology could be a novel therapy. Read More

Neurol India 2022 Mar-Apr;70(2):510-514

Department of Spine Surgery Bumin Hospital, Busan, South Korea.

Background And Introduction: Minimally invasive spine surgery (MISS) is a set of techniques and procedures that reduces the local tissue injury while achieving the same results through traditional open surgery. The techniques for the treatment of lumbar disc herniation and degenerative canal stenosis have evolved from tubular discectomy to endoscopic discectomy. This helps in preserving spine function. Read More

Arch Soc Esp Oftalmol (Engl Ed) 2022 May 11;97(5):281-285. Epub 2022 Mar 11.

Departamento de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, Spain; Departamento de Oftalmología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain.

We present a clinical situation where a 47-year old female patient consulted with left partial ptosis and miosis that started, two weeks before, with an episode of glandular fever secondary to Epstein-Barr infection. Apraclonidine 0.5% and Phenylephrine 1% drop testing was performed with results consistent with suspected left Horner Syndrome (HS), with a probable postganglionic location. Read More

Medicine (Baltimore) 2022 Apr 29;101(17):e29225. Epub 2022 Apr 29.

Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea.

Rationale: Transvaginal evisceration of the small bowel is an extremely rare condition after hysterectomy, which requires urgent surgical intervention to prevent serious bowel morbidity and mortality.

Patient Concerns: A 65-year-old woman presented with sudden-onset severe abdominal pain and a mass protruding through the vagina. The past surgical history was significant, with an abdominal hysterectomy for cervical cancer performed 11 weeks prior to presentation. Read More

BMC Surg 2022 May 4;22(1):157. Epub 2022 May 4.

Department of General Surgery, Unit of Gastrointestinal, Hepato-Biliary and Pancreatic Surgery, University Hospital "Alexandrovska", Sofia, Medical University of Sofia, 1 G.Sofiiski Str., 1431, Sofia, Bulgaria.

Background: Transvaginal intestinal evisceration is an extremely rare surgical emergency with potentially fatal consequences. Only a few more than 100 cases with this pathology have been described in the literature. Aetiology is also unclear and multifactoral. Read More

BMC Gastroenterol 2022 May 4;22(1):220. Epub 2022 May 4.

The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Biliary dilatation is a rare disease involving intrahepatic and extrahepatic biliary tract abnormalities. With the development of imaging technology, an increasing number of special cases have been diagnosed, which poses a challenge to the traditional classification method.

Case Presentation: A 50-year-old woman was admitted to the hospital due to right upper quadrant pain for more than 10 days. Read More

Prague Med Rep 2022 ;123(2):113-119

Department of Radiotherapy, Iran University of Medical Sciences, 7Tir Hospital, Tehran, Iran.

Eosinophilic angiocentric fibrosis (EAF) is a rare progressive fibrosing lesion involving the nasal cavity, paranasal sinuses, and the upper respiratory tract. There are few reports that it rarely involves the orbit; however, there is no report of intracranial involvement. Here, we report and share our experience with a rare case of primary intracranial EAF. Read More

BMC Neurol 2022 May 3;22(1):168. Epub 2022 May 3.

Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: HINT1 mutations cause an autosomal recessive axonal neuropathy with neuromyotonia. This is a first case report of coexistence of myasthenia gravis (MG) and HINT1-related motor axonal neuropathy without neuromyotonia.

Case Presentation: A 32-year-old woman presented with recurrent ptosis for 8 years, diplopia for 2 years and limb weakness for 1 year and a half. Read More