27,215 results match your criteria Psychopharmacology Bulletin[Journal]


Contribution of monoaminergic mechanisms to the discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) in Sprague-Dawley rats.

Psychopharmacology (Berl) 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, Western Michigan University, Kalamazoo, MI, 49008, USA.

Rationale: 3,4-Methylenedioxypyrovalerone (MDPV) is a popular synthetic cathinone reported to have a high abuse potential. Recent preclinical research indicates the psychopharmacology of MDPV is comparable to cocaine. Despite a recent influx of research on the psychopharmacology of MDPV, few studies have employed preclinical drug discrimination methods to discern the neurochemical mechanisms involved in its interoceptive stimulus effects. Read More

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December 2018

Cannabis induced increase in striatal glutamate associated with loss of functional corticostriatal connectivity.

Eur Neuropsychopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Cannabis is the most commonly used illicit drug and is known to alter state of consciousness and impair neurocognitive function. However, the mechanisms underlying these effects have yet to be fully elucidated. Rodent studies suggest that Δ9-tetrahydrocannabinol (THC) activates dopaminergic neurons in the limbic system, subsequently enhancing dopamine, which is implicated in the rewarding effects of cannabis. Read More

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December 2018

Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with a extract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity.

BMJ Open 2018 Dec 14;8(12):e022195. Epub 2018 Dec 14.

Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia.

Introduction: Hyperlipidaemia, hyperglycaemia and chronic inflammation are risk factors for chronic diseases cardiovascular disease and type 2 diabetes. Polyphenols are bioactive compounds found in marine algae with potential antihyperlipidaemic, antihyperglycaemic and anti-inflammatory effects. The modulation of these risk factors using bioactive polyphenols may represent a useful strategy for disease prevention and management; research in humans, however, remains limited. Read More

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December 2018
1 Read

Recent Changes in Drug Abuse Scenarios: The New/Novel Psychoactive Substances (NPS) Phenomenon.

Brain Sci 2018 Dec 13;8(12). Epub 2018 Dec 13.

Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, University of Hertfordshire, Hertfordshire AL10 9AB, UK.

Over the last decade, the emergence of a vast range of new/novel/emerging psychoactive substances (NPS) has progressively changed drug market scenarios, which have shifted from the 'street' to a 'virtual'/online environment. [.. Read More

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December 2018

Pharmacogenomic assessment of herbal drugs in affective disorders.

Biomed Pharmacother 2019 Jan 6;109:1148-1162. Epub 2018 Nov 6.

Sunandan Divatia School of Science, NMIMS (Deemed-to-be University), Vile Parle (W), Mumbai, 400 056, Maharashtra, India. Electronic address:

Anxiety and depression, the most prevalent psychiatric disorders are co-morbid in nature affecting several people across the world. There is an increase in demand for complementary and alternative medicines, specifically herbal botanicals due to various side effects exhibited by conventional drugs. Herbal drugs mentioned in traditional medicines, face acceptance issues by the medical community due to lack of scientific data regarding their neurochemical pathways. Read More

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January 2019
1 Read

How to Read a Research Paper: An Exercise in Critical Thinking in the Context of an Epidemiologic Study on Tamsulosin and the Risk of Dementia.

J Clin Psychiatry 2018 Dec 11;79(6). Epub 2018 Dec 11.

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.

A recent study of the relationship between tamsulosin and dementia found that, in propensity score-matched analyses that adjusted for measured risk factors for dementia, the use of tamsulosin to treat benign prostatic hyperplasia (BPH) was associated with a small but significant increase in the risk of incident dementia relative to untreated BPH, BPH treated with the 5α-reductase inhibitors dutasteride and finasteride, and BPH treated with the α adrenoceptor blockers doxazosin, terazosin, and alfuzosin. The choice of control groups addressed confounding by indication, confounding by disease severity, and confounding by pharmacologic drug class. The authors of the study provided a wealth of detail in their main paper and in supplementary materials, allowing an almost forensic examination of the findings. Read More

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December 2018

Why Odds Ratios Can Be Tricky Statistics: The Case of Finasteride, Dutasteride, and Sexual Dysfunction.

J Clin Psychiatry 2018 Nov 27;79(6). Epub 2018 Nov 27.

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Finasteride and dutasteride are 5α-reductase inhibitor drugs that are used to treat benign prostatic hyperplasia (BPH). Randomized controlled trials (RCTs) conducted in men with BPH show that these drugs impair libido and cause erectile dysfunction. Meta-analyses of the RCTs confirm the findings, estimating odds ratio (OR) values for these adverse effects at around 1. Read More

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November 2018

Neuronal cell adhesion molecule regulating neural systems underlying addiction.

Neuropsychopharmacol Rep 2018 Dec 13. Epub 2018 Dec 13.

Department of Biology, William Paterson University, Wayne, New Jersey.

Aims: The human NRCAM gene is associated with polysubstance use. Nrcam knockout mice do not acquire a preference for addictive substances. We aimed to elucidate the role of Nrcam in specific neural circuits underlying congenital preference for substances and the acquisition of addiction. Read More

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December 2018

Guidelines for the Treatment of PTSD Using Clinical EFT (Emotional Freedom Techniques).

Healthcare (Basel) 2018 Dec 12;6(4). Epub 2018 Dec 12.

School of Psychology, Faculty of Society and Design, Bond University, Robina, Gold Coast, QLD 4229, Australia.

Clinical EFT (Emotional Freedom Techniques) is an evidence-based method that combines acupressure with elements drawn from cognitive and exposure therapies. The approach has been validated in more than 100 clinical trials. Its efficacy for post-traumatic stress disorder (PTSD) has been investigated in a variety of demographic groups including war veterans, victims of sexual violence, the spouses of PTSD sufferers, motor accident survivors, prisoners, hospital patients, adolescents, and survivors of natural and human-caused disasters. Read More

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December 2018

Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder.

Front Psychiatry 2018 27;9:637. Epub 2018 Nov 27.

Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.

Posttraumatic stress disorder (PTSD) is a trauma and stressor related disorder that may develop after exposure to an event that involved the actual or possible threat of death, violence or serious injury. Its molecular underpinning is still not clear. Brain-derived neurotrophic factor (BDNF) modulates neuronal processes such as the response to stress, but also weight control, energy and glucose homeostasis. Read More

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November 2018

Running-down phenomenon captured with chronic electrocorticography.

Epilepsia Open 2018 Dec 19;3(4):528-534. Epub 2018 Oct 19.

Department of Neurology NYU School of Medicine New York New York U.S.A.

The running-down phenomenon refers to 2 analogous but distinct entities that may be seen after epilepsy surgery. The first is clinical, and denotes a progressive diminution in seizures after epilepsy surgery in which the epileptogenic zone could not be completely removed (Modern Problems of Psychopharmacology 1970;4:306, Brain 1996:989). The second is electrographic, and refers to a progressive deactivation of a secondary seizure focus after removal of the primary epileptogenic zone. Read More

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December 2018

Anti-cytokine agents for anhedonia: targeting inflammation and the immune system to treat dimensional disturbances in depression.

Ther Adv Psychopharmacol 2018 Dec 19;8(12):337-348. Epub 2018 Nov 19.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada Brain and Cognition Discovery Foundation, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Psychiatry, University of Toronto, Toronto, ON, Canada Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

The etiology of mood disorders is mechanistically heterogeneous, underscoring the need for a dimensional approach to identify and develop targeted treatments in psychiatry. Accumulating evidence implicates inflammation as an important contributor to the pathophysiology of depression and presents the immune system as a viable therapeutic target that may be more proximate to the pathogenic nexus of brain-based disorders in specific subpopulations. Anhedonia is a transdiagnostic (e. Read More

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December 2018
1 Read

Novel developments in .

Ther Adv Psychopharmacol 2018 Dec 19;8(12):329-331. Epub 2018 Nov 19.

Editor-in-Chief, Therapeutic Advances in Psychopharmacology, Maudsley Hospital, London, UK.

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December 2018

Screening for ADHD-Related Symptoms in Preschoolers Should Be Considered-Results From a Representative Sample of 5-Year-Olds From a German Metropolitan Region.

Front Psychiatry 2018 20;9:612. Epub 2018 Nov 20.

Pediatric Psychopharmacology, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Early assessment and intervention are crucial to alleviate symptoms and prevent long-term negative outcomes in children suffering from Attention-deficit/hyperactivity disorder (ADHD). In Germany, at present, no standardized screening for ADHD is routinely administered. This study aims to evaluate a potential screening measure in a study population that is representative for a primary school entrance exam population in a German metropolitan region. Read More

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November 2018

Substantial differences in serum concentrations of psychoactive drugs measured in samples stored for two days or more on standard serum tubes versus serum tubes containing gel separators.

Ther Drug Monit 2018 Dec 11. Epub 2018 Dec 11.

Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.

Background: Drugs may potentially adsorb to blood collection tubes containing gel separators in the pre-analytical phase of therapeutic drug monitoring (TDM). The aim of this study was to compare measured concentrations of 28 psychoactive drugs and 13 metabolites in spiked serum samples stored on standard (plain) tubes vs. barrier gel tubes during a 2-6 days period at room temperature. Read More

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December 2018

Activation of somatodendritic 5-HT autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test.

Psychopharmacology (Berl) 2018 Dec 12. Epub 2018 Dec 12.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Rationale: Fear conditioning is an important factor in the etiology of anxiety disorders. Previous studies have demonstrated a role for serotonin (5-HT) receptors in fear conditioning. However, the relative contribution of somatodendritic 5-HT autoreceptors and post-synaptic 5-HT heteroreceptors in fear conditioning is still unclear. Read More

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December 2018

No effect of sex on ethanol intake and preference after dopamine transporter (DAT) knockdown in adult mice.

Psychopharmacology (Berl) 2018 Dec 12. Epub 2018 Dec 12.

Division of Biochemistry, Department of Medicine, University of Fribourg, 1700, Fribourg, Switzerland.

Rationale: Dopamine levels are controlled in part by transport across the cell membrane by the dopamine transporter (DAT), and recent evidence showed that a polymorphism in the gene encoding DAT is associated with alcoholism. However, research in animal models using DAT knockout mice has yielded conflicting results.

Objectives: The present study was planned to evaluate the effects of DAT knockdown in the nucleus accumbens (Nacc) on voluntary ethanol consumption and preference in male and female C57BL/6J mice. Read More

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December 2018
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Neuronal nitric oxide synthase activity mediates Lycium barbarum polysaccharides-enhanced sexual performance without stimulating noncontact erection in rats.

Psychopharmacology (Berl) 2018 Dec 11. Epub 2018 Dec 11.

Department of Physical Therapy, Hung Kuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung, 43302, Taiwan.

Rationale: Lycium barbarum polysaccharide (LBP) is known to promote reproductive functions. However, its role in noncontact erection (NCE) of penis initiated by brain regions including medial preoptic area (MPOA) and paraventricular nucleus (PVN) regions responsible for sexual behavior has not been investigated.

Objectives: Therefore, this study initially investigated the effects of LBP on male sexual function, and subsequently, the mechanistic insight was investigated through assessing the expression of neuronal nitric oxide synthase (nNOS) in the MPOA and PVN. Read More

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December 2018

Randomized, double-blind, placebo-controlled, crossover study of the effects of repeated-dose caffeine on neurobehavioral performance during 48 h of total sleep deprivation.

Psychopharmacology (Berl) 2018 Dec 11. Epub 2018 Dec 11.

Sleep and Performance Research Center and Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.

Rationale: Caffeine is widely used as a countermeasure against neurobehavioral impairment during sleep deprivation. However, little is known about the pharmacodynamic profile of caffeine administered repeatedly during total sleep deprivation.

Objectives: To investigate the effects of repeated caffeine dosing on neurobehavioral performance during sleep deprivation, we conducted a laboratory-based, randomized, double-blind, placebo-controlled, crossover, multi-dose study of repeated caffeine administration during 48 h of sleep deprivation. Read More

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December 2018

Brain structural networks and connectomes: the brain-obesity interface and its impact on mental health.

Neuropsychiatr Dis Treat 2018 26;14:3199-3208. Epub 2018 Nov 26.

Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan,

Purpose: Obesity is a complex and multifactorial disease identified as a global epidemic. Convergent evidence indicates that obesity differentially influences patients with neuropsychiatric disorders providing a basis for hypothesizing that obesity alters brain structure and function associated with the brain's propensity toward disturbances in mood and cognition. Herein, we characterize alterations in brain structures and networks among obese subjects (ie, body mass index [BMI] ≥30 kg/m) when compared with non-obese controls. Read More

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November 2018

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018
3 Reads

Age-related differences in task-induced brain activation is not task specific: Multivariate pattern generalization between metacognition, cognition and perception.

Neuroimage 2018 Dec 8. Epub 2018 Dec 8.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands.

Adolescence is associated with widespread maturation of brain structures and functional connectivity profiles that shift from local to more distributed and better integrated networks, which are active during a variety of cognitive tasks. Nevertheless, the approach to examine task-induced developmental brain changes is function-specific, leaving the question open whether functional maturation is specific to the particular cognitive demands of the task used, or generalizes across different tasks. In the present study we examine the hypothesis that functional brain maturation is driven by global changes in how the brain handles cognitive demands. Read More

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December 2018
2 Reads

An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients.

Psychopharmacology (Berl) 2018 Dec 8. Epub 2018 Dec 8.

Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, SE5 8AF, UK.

Rationale: Schizophrenia is associated with impairments in cognitive functioning yet there are no approved drugs to treat these deficits.

Objectives: Based on animal models, we investigated the potential for roflumilast, a selective inhibitor of phosphodiesterase type 4 (PDE4), to improve cognition, which may act by increasing intracellular cyclic adenosine monophosphate in brain regions underlying cognitive deficits in schizophrenia.

Methods: This study consisted of a randomised, double-blind, placebo-controlled, crossover design involving 15 schizophrenia patients. Read More

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December 2018

Nucleus accumbens dopamine increases sexual motivation in sexually satiated male rats.

Psychopharmacology (Berl) 2018 Dec 8. Epub 2018 Dec 8.

Departamento de Farmacobiologia, Cinvestav Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, Ciudad de México, 14330, México.

Rationale: The influence of the main dopaminergic brain regions controlling copulation, the medial preoptic area (mPOA) and the nucleus accumbens (NAcc), on male rat sexual behavior expression has not been fully established.

Objective: This work analyzes the sexual effects of dopamine (DA) receptor activation in the mPOA or the NAcc of sexually active male rats, with an intact (sexually experienced) or a reduced (sexually exhausted) sexual motivation.

Methods: The non-specific DA receptor agonist apomorphine and the D2-like receptor agonist quinpirole were infused into the mPOA or the NAcc of sexually experienced or sexually exhausted male rats and their sexual behavior recorded. Read More

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December 2018

Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats.

Psychopharmacology (Berl) 2018 Dec 10. Epub 2018 Dec 10.

School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

Rationale: Social withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e. Read More

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December 2018
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How to Read a Research Paper: An Exercise Using a Study on Continuation vs. Discontinuation of Antidepressants during Pregnancy.

Indian J Psychol Med 2018 Nov-Dec;40(6):600-601

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

The ability to critically read a research paper is a skill that all postgraduate students and academicians require because the findings of a study must be interpreted in the context of its strengths and limitations. This article summarizes a recent study on continuation vs. discontinuation of antidepressants during pregnancy; preterm birth and low-birth weight were the outcomes of interest. Read More

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December 2018

Comments on "Screening for Mental Health Disorders among Pregnant Women Availing Antenatal Care at a Government Maternity Hospital in Bengaluru City".

Indian J Psychol Med 2018 Nov-Dec;40(6):598-599

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

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December 2018

Author's Response to Comments on "Prenatal Depression and Infant Health: The Importance of Inadequately Measured, Unmeasured and Unknown Confounds".

Indian J Psychol Med 2018 Nov-Dec;40(6):594-595

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

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December 2018

Internal, External, and Ecological Validity in the Context of Studies on Advance Directives.

Indian J Psychol Med 2018 Nov-Dec;40(6):589-590

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

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December 2018

Revisiting the International Physical Activity Questionnaire (IPAQ): Assessing sitting time among individuals with schizophrenia.

Psychiatry Res 2018 Nov 27;271:311-318. Epub 2018 Nov 27.

School of Kinesiology, University of British Columbia, 2148 Health Sciences Mall, Room 4008, Vancouver, BC V6T 1Z8, Canada.

While moderate to vigorous physical activity may be one method of addressing common physical morbidities in schizophrenia, reducing sedentary time may be a low intensity adjunct. In order to determine whether sedentary behaviour is associated with health outcomes, valid and reliable tools for assessing sedentary time are necessary. In order to characterize the validity and reliability of the International Physical Activity Questionnaire (IPAQ) for assessing sitting (sedentary) time, participants completed the IPAQ at baseline and 4 weeks later and wore accelerometers for 7 days before the final assessment. Read More

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November 2018

Theranostic pharmacology in PTSD: Neurobiology and timing.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Olive View Medical Center, Sylmar, CA, USA.

Recent reviews and treatment guidelines regard trauma-focused cognitive-behavior therapies as the treatments of choice for chronic post-traumatic stress disorder (PTSD). However, many patients do not engage in this treatment when it is available, drop out before completion, or do not respond. Medications remain widely used, alone and in conjunction with psychotherapy, although the limitations of traditional monoamine-based pharmacotherapy are increasingly recognized. Read More

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December 2018

Age-dependent differences in the impact of paediatric traumatic brain injury on executive functions: A prospective study using susceptibility-weighted imaging.

Neuropsychologia 2018 Dec 5. Epub 2018 Dec 5.

Australian Centre for Child Neuropsychological Studies, Murdoch Children's Research Institute, Flemington Road, Parkville, 3052 Melbourne, Australia; Department of Psychology, Royal Children's Hospital, Melbourne, Australia; Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia. Electronic address:

Childhood and adolescence represent sensitive developmental periods for brain networks implicated in a range of complex skills, including executive functions (EF; inhibitory control, working memory, and cognitive flexibility). As a consequence, these skills may be particularly vulnerable to injuries sustained during these sensitive developmental periods. The present study investigated 1) whether age at injury differentially affects EF 6 months and 2 years after TBI in children aged 5-15 years, and 2) whether the association between brain lesions and EF depend on age at injury. Read More

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December 2018

Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition.

Br J Psychiatry 2018 Dec 6:1-9. Epub 2018 Dec 6.

Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.

Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More

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December 2018
5 Reads

Response to the Letter from Dr. Jacob Peedicayil.

Psychopharmacology (Berl) 2018 Dec 5. Epub 2018 Dec 5.

Department of Psychiatry, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

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December 2018
1 Read

Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial.

Psychopharmacology (Berl) 2018 Dec 5. Epub 2018 Dec 5.

Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Rationale: Individuals with schizophrenia are at increased risk of developing metabolic syndrome (MetS) due to their lifestyle and antipsychotic treatment. Our previous study showed that patients with both schizophrenia and MetS present an increased expression and production of tumor necrosis factor-alpha (TNF-alpha). Omega-3 fatty acids have a documented role in suppressing TNF-alpha; therefore, we hypothesized that they may be of value in relieving inflammation and improving metabolic disturbance in patients with both schizophrenia and MetS. Read More

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December 2018
2 Reads
3.875 Impact Factor

Thirty-year cardiovascular risk score in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives.

Aust N Z J Psychiatry 2018 Dec 5:4867418815987. Epub 2018 Dec 5.

1 The Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Objectives:: Bipolar disorder is associated with a decreased life expectancy of 8-12 years. Cardiovascular disease is the leading cause of excess mortality. For the first time, we investigated the Framingham 30-year risk score of cardiovascular disease in patients with newly diagnosed/first-episode bipolar disorder, their unaffected first-degree relatives and healthy individuals. Read More

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December 2018

Anxiolytic-like effects of the new arylpiperazine derivatives containing isonicotinic and picolinic nucleus: behavioral and biochemical studies.

Fundam Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.

Anxiety disorder is a great challenge for modern psychopharmacology. Although a variety of single drugs are used in the treatment of anxiety, it is important to search for new therapeutics with faster onset of action, fewer side effects and higher efficacy. In this work, we studied the possible anxiolytic action mechanism of two new arylpiperazine derivatives: compounds 4p N-(3-(4-(piperonyl)piperazin-1-yl)propyl)isonicotinamide and 3o N-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)picolinamide, focusing on their effects on the GABA-ergic and 5-HT systems. Read More

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December 2018

The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals.

Clin Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.

General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Italy.

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. Read More

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December 2018
4 Reads
7.903 Impact Factor

Maximizing response to first-line antipsychotics in schizophrenia: a review focused on finding from meta-analysis.

Psychopharmacology (Berl) 2018 Nov 30. Epub 2018 Nov 30.

Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Rationale: There are many psychotropic drugs available for treatment of schizophrenia. The clinician's choice of the most effective first-line antipsychotic treatment for patients with schizophrenia should balance considerations of differential efficacy of antipsychotics against the relative risk of different side effects.

Method: We reviewed recent studies using meta-analytic techniques and additional studies of new antipsychotics which quantitatively evaluate the efficacy of side effects of first- and second-generation antipsychotics and studies of the efficacy on add-on secondary medications. Read More

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November 2018
1 Read

Increased cocaine reward in offspring of females exposed to morphine during adolescence.

Psychopharmacology (Berl) 2018 Nov 30. Epub 2018 Nov 30.

Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA, 01536, USA.

Rationale: A growing body of evidence demonstrates that environmental exposures can impact the physiology and behavior of subsequent generations. We have previously demonstrated reduced morphine self-administration in the F1 and F2 offspring of female rats exposed to morphine during adolescence.

Objectives: The current study was designed to determine whether attenuated self-administration for a substance not in the opioid class is also observed in the F1 progeny of adolescent morphine exposed females. Read More

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November 2018
3 Reads

Neuroepigenetic mechanisms underlying fear extinction: emerging concepts.

Psychopharmacology (Berl) 2018 Nov 30. Epub 2018 Nov 30.

Cognitive Neuroepigenetics Laboratory, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.

An understanding of how memory is acquired and how it can be modified in fear-related anxiety disorders, with the enhancement of failing memories on one side and a reduction or elimination of traumatic memories on the other, is a key unmet challenge in the fields of neuroscience and neuropsychiatry. The latter process depends on an important form of learning called fear extinction, where a previously acquired fear-related memory is decoupled from its ability to control behaviour through repeated non-reinforced exposure to the original fear-inducing cue. Although simple in description, fear extinction relies on a complex pattern of brain region and cell-type specific processes, some of which are unique to this form of learning and, for better or worse, contribute to the inherent instability of fear extinction memory. Read More

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November 2018
1 Read

The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies.

Sleep Med Rev 2018 Nov 8;43:37-46. Epub 2018 Nov 8.

"Vita-Salute" San Raffaele University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology - Sleep Disorders Centre, Milan, Italy. Electronic address:

Several studies report an association between REM Sleep Behavior Disorder (RBD) and neurodegenerative diseases, in particular synucleinopathies. Interestingly, the onset of RBD precedes the development of neurodegeneration by several years. This review and meta-analysis aims to establish the rate of conversion of RBD into neurodegenerative diseases. Read More

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November 2018
1 Read

An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses.

J Anal Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Department of Forensic Sciences,Oslo University Hospital Nydalen, Oslo, Norway.

Benzodiazepines are commonly seen in samples submitted for drug testing of patients, people involved in child welfare cases, work-place drug testing, as well as in drug-facilitated assaults. Limited previous experimental studies are available regarding the excretion of benzodiazepines in urine and oral fluid. The aim of this study was to investigate the concentrations of diazepam and alprazolam in oral fluid and urine for up to 2 weeks after ingestion of a single oral dose in healthy volunteers. Read More

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December 2018
2 Reads

Clinical Psychopharmacology in Switzerland.

Authors:
Pierre Baumann

J Clin Psychopharmacol 2018 Dec 3. Epub 2018 Dec 3.

From the Département de Psychiatrie (DP-CHUV) Université de Lausanne, Prilly-Lausanne, Switzerland.

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December 2018
4 Reads

A clinical trial on the acute effects of methadone and buprenorphine on actual driving and cognitive function of healthy volunteers.

Br J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, University of Maastricht, Maastricht, The Netherlands.

Aims: The present study assessed the acute effects of methadone and buprenorphine on actual on-road driving performance and neurocognitive function.

Methods: Methadone (5 and 10 mg per oral) and buprenorphine (0.2 and 0. Read More

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December 2018
1 Read

Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer's disease.

Psychopharmacology (Berl) 2018 Dec 4. Epub 2018 Dec 4.

Drug Applied Research Center, Tabriz University of Medical Sciences, P.O. Box 51656-65811, Tabriz, Iran.

Rationale: Considerable clinical and experimental studies have shown that depression-related disorders are the most common neuropsychiatric symptoms in Alzheimer's disease (AD), affecting as many as 20-40% of patients. An increasing amount of evidence shows that monoamine-based antidepressant treatments are not completely effective for depression treatment in patients with dementia. Minocycline, a second-generation tetracycline antibiotic, has been gaining research and clinical attention for the treatment of different neuropsychiatric disorders, and more recently depression symptom in humans. Read More

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December 2018
1 Read

The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia.

A diet rich in B-group vitamins is essential for optimal body and brain function, and insufficient amounts of such vitamins have been associated with higher levels of neural inflammation and oxidative stress, as marked by increased blood plasma homocysteine. Neural biomarkers of oxidative stress quantified through proton magnetic spectroscopy (1H-MRS) are not well understood, and the relationship between such neural and blood biomarkers is seldom studied. The current study addresses this gap by investigating the direct effect of 6-month high-dose B-group vitamin supplementation on neural and blood biomarkers of metabolism. Read More

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December 2018

Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology.

Acta Neuropathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

TAR DNA-binding protein 43 (TDP-43) aggregation is the most common pathological hallmark in frontotemporal dementia (FTD) and characterizes nearly all patients with motor neuron disease (MND). The earliest stages of TDP-43 pathobiology are not well-characterized, and whether neurodegeneration results from TDP-43 loss-of-function or aggregation remains unclear. In the behavioral variant of FTD (bvFTD), patients undergo selective dropout of von Economo neurons (VENs) and fork cells within the frontoinsular (FI) and anterior cingulate cortices. Read More

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December 2018
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Mental Health Treatment Quality, Access, and Satisfaction: Optimizing Staffing in an Era of Fiscal Accountability.

Psychiatr Serv 2018 Nov 30:appips201800229. Epub 2018 Nov 30.

Program Evaluation and Resource Center, Veterans Health Administration (VHA) Office of Mental Health and Suicide Prevention, Menlo Park, California (Boden, Trafton); Center for Innovation to Implementation, VHA Palo Alto Health Care System, Palo Alto, California (Boden); Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California (Trafton); VHA Office of Mental Health and Suicide Prevention, Washington, D.C. (Smith, Klocek).

Objective:: Mental health treatment access and quality are influenced by the interplay of structural, organizational, and performance factors-including the number of mental health staff providing direct clinical care relative to patients treated (i.e., staffing ratio), mental health staff productivity, and wait times for scheduled mental health appointments. Read More

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November 2018