7,764 results match your criteria Psychogenic Nonepileptic Seizures


Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Departments of Medicine (S.S., Z.C., A.P., C.J.R., N.C.J., C.F., P.P., P.K., T.J.O.), Neurology (S.S., E.J.W., A.P., C.H., J.C., C.J.R., R.Y., C.F., P.P., P.K., T.J.O.), and Respiratory and Sleep Disorders Medicine (T.M., J.G.), The Royal Melbourne Hospital, The University of Melbourne, Parkville; Department of Neuroscience (S.S., Z.C., A.P., N.C.J., C.F., P.P., P.K., T.J.O.), Central Clinical School, Monash University; Department of Neurology (S.S., A.P., P.P., P.K., T.J.O.), The Alfred Hospital; and Neuropsychiatry Unit (S.F., D.V.), The Royal Melbourne Hospital and Melbourne Neuropsychiatry Centre, Australia.

Objective: To examine the prevalence and risk factors of sleep-disordered breathing (SDB) in individuals with epilepsy and psychogenic nonepileptic seizures (PNES).

Methods: We conducted a cross-sectional study of consecutive patients admitted for inpatient video-EEG monitoring at The Royal Melbourne Hospital, Australia, between December 1, 2011, and July 31, 2017. Participants underwent routine clinical investigations during their monitoring period including polysomnography, neurocognitive testing, and screening instruments of daytime somnolence, sleep quality, and quality of life. Read More

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December 2018

Diagnosis and Management of Delusional Parasitosis.

J Am Acad Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychiatry, Medical University of South Carolina.

Delusional parasitosis is a monosymptomatic hypochondriacal state that causes great suffering for the patient and those around them. Dermatologists are experts in the diagnosis of cutaneous disease and frequently encounter such patients. This review provides an overview of the diagnosis and management of delusional parasitosis as well as the differential diagnosis. Read More

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December 2018

Novel features for capturing temporal variations of rhythmic limb movement to distinguish convulsive epileptic and psychogenic nonepileptic seizures.

Epilepsia 2018 Dec 9. Epub 2018 Dec 9.

Department of Electrical and Electronic Engineering, The University of Melbourne, Melbourne, Victoria, Australia.

Objective: To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNES.

Methods: In this study, motor data were recorded using wrist-worn ACM-based devices. Read More

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December 2018

Neuroinflammation contributes to high salt intake-augmented neuronal activation and active coping responses to acute stress.

Int J Neuropsychopharmacol 2018 Dec 8. Epub 2018 Dec 8.

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

High dietary salt intake (HDSI) increases risk of stress-related neuropsychiatric disorders. Here, we explored the contribution of HDSI-induced neuroinflammation in key stress-responsive brain regions, the hypothalamic paraventricular nucleus (PVN) and basolateral amygdala (BLA), in promoting exaggerated neuronal activation and coping behaviors in response to acute psychogenic stress. Mice that underwent HDSI exhibited increased active stress coping behaviors during and after an acute swim stress, and these were reduced by concurrent administration of minocycline, an inhibitor of microglial activation, without affecting body fluid hyperosmolality caused by HDSI. Read More

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December 2018

Risk factors for the use of antiepileptic drugs in patients with psychogenic nonepileptic seizures.

Epilepsy Behav 2018 Dec 7;90:119-121. Epub 2018 Dec 7.

Neuroscience Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The aim of this study was to investigate the frequency of antiepileptic drug (AED) use in patients with psychogenic nonepileptic seizures (PNES) and to characterize the patients' historical risk factors that may be associated with such a practice.

Methods: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were studied. Patients with concomitant epilepsy or abnormal Electroencephalogram (EEG) were not included. Read More

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December 2018

Psychogenic nonepileptic seizures in children and adolescents: An international cross-cultural study.

Epilepsy Behav 2018 Dec 2;90:90-92. Epub 2018 Dec 2.

Children's Comprehensive Epilepsy Center, Alberta Children's Hospital, Calgary, Canada; Alberta Children's Hospital Research Institute, Calgary, Canada; Cumming School of Medicine, University of Calgary, Alberta, Canada. Electronic address:

Purpose: We compared various clinical characteristics of psychogenic nonepileptic seizures (PNES) between young patients from Iran, Saudi Arabia, and Canada, three nations with significantly different socioeconomic and demographic characteristics. This international cross-cultural comparative study may advance our knowledge and understanding of PNES in children and adolescents across the cultures and borders.

Methods: In this retrospective study, we investigated all patients 16 years of age or younger, with PNES admitted to the epilepsy monitoring units at one center in Iran, one center in Saudi Arabia, and one center in Canada. Read More

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December 2018
2 Reads

Functional Movement Disorders and Placebo: A Brief Review of the Placebo Effect in Movement Disorders and Ethical Considerations for Placebo Therapy.

Mov Disord Clin Pract 2018 Sep-Oct;5(5):471-478. Epub 2018 Oct 9.

Department of Neurology Johns Hopkins University School of Medicine Baltimore MD.

Background: Functional movement disorders are common and disabling neurologic conditions. Patients with functional neurologic disorders represent a large proportion of neurology clinic referrals, and limited availability of subspecialty care creates a considerable burden for the healthcare system. These conditions are currently treated with a combination of physical therapy and cognitive behavioral therapy, with variable success. Read More

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October 2018
1 Read

Temporally linked occurrences of epileptic and psychogenic nonepileptic seizures - Coincidental or pathogenically related?

Seizure 2018 Nov 28;64:20-22. Epub 2018 Nov 28.

Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA; Neurology Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA. Electronic address:

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November 2018

[Erectile dysfunction, an urologic and multidisciplinary approach].

Rev Med Suisse 2018 Nov;14(629):2172-2176

Service d'urologie, Département de chirurgie, HUG, 1211 Genève 14.

Erectile dysfunction (ED) is a common complaint, both in the general medicine and the urology out-patient clinic. The quite recent availability of effective treatments has profoundly changed the perception of sexual health in society, which has become more demanding. We should see erectile or sexual function as a health marker. Read More

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November 2018
2 Reads

Functional (psychogenic) gait disorder: diagnosis and management.

Authors:
Mark Edwards

Handb Clin Neurol 2018 ;159:417-423

Department of Neurology, St. George's, University of London, London, United Kingdom. Electronic address:

Functional (psychogenic) gait disorders are a common presentation of functional neurological disorder - one of the commonest diagnoses made in neurology practice. People with functional neurological disorder are as disabled and experience as poor a quality of life as patients with multiple sclerosis and Parkinson's disease. People with functional neurological disorder, including gait disorder, are often perceived as being challenging to diagnose and manage, and as a result attitudes of health professionals towards them are often negative. Read More

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January 2018

Neuroimaging Applications in Functional Movement Disorders.

Int Rev Neurobiol 2018 13;143:163-177. Epub 2018 Nov 13.

Neuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University of London, London, United Kingdom. Electronic address:

Functional (psychogenic) movement disorders are a subtype of functional neurological disorder, a common and disabling cause of neurological symptoms. Abnormal movement in people with functional movement disorders has specific characteristics (e.g. Read More

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November 2018
2 Reads

Abnormal postural behavior in patients with functional movement disorders during exposure to stress.

Psychoneuroendocrinology 2018 Nov 14;101:232-239. Epub 2018 Nov 14.

Department of Neurology, Inselspital, Bern University Hospital, Freiburgstrasse, CH-3010 Bern, Switzerland; Department of Neuroscience, Faculty of Medicine, University of Geneva, 24 rue du Général-Dufour, 1211 Geneva, Switzerland. Electronic address:

Background: Patients affected by functional (psychogenic) movement disorders (FMD) have abnormal processing of stress responses. However, little is known about the influence of this abnormal stress processing on automatic motor defense behavior, such as freeze response. Our aim was thus to investigate stress-induced postural motor responses in FMD. Read More

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November 2018
5 Reads

Stress-induced hyperthermia and hypothermia.

Authors:
Takakazu Oka

Handb Clin Neurol 2018 ;157:599-621

Department of Psychosomatic Medicine, International University of Health and Welfare Hospital, Tochigi-ken, Japan. Electronic address:

Stress affects core body temperature (T). Many kinds of stress induce transient, monophasic hyperthermia, which diminishes gradually if the stressor is terminated. Stronger stressors produce a longer-lasting effect. Read More

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January 2018
3 Reads

Emotional processing in functional neurological disorder: a review, biopsychosocial model and research agenda.

J Neurol Neurosurg Psychiatry 2018 Nov 19. Epub 2018 Nov 19.

Section of Cognitive Neuropsychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Functional neurological disorder (FND) is a common and highly disabling disorder, but its aetiology remains enigmatic. Conceptually, there has been reduced emphasis on the role of psychosocial stressors in recent years, with a corresponding increase in neurobiological explanations. However, a wealth of evidence supports the role of psychosocial adversities (eg, stressful life events, interpersonal difficulties) as important risk factors for FND. Read More

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November 2018
3 Reads

Improved Detection and Classification of Convulsive Epileptic and Psychogenic Non-epileptic Seizures Using FLDA and Bayesian Inference.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:3402-3405

A high number of patients with epileptic seizures (ES) are misdiagnosed due to prevalence of mimic conditions. The clinical characteristics of mimics are often similar to ES. The events mostly misdiagnosed are of psychogenic origin and are termed as psychogenic non-epileptic seizures (PNES). Read More

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A Systematic Review of the Reported Proportions of Diagnoses for Dizziness and Vertigo.

Otol Neurotol 2019 Jan;40(1):6-15

School of Allied Health, Australian Catholic University.

Objectives: To determine the typical proportions of diagnoses for patients presenting with dizziness or vertigo based on clinical speciality and to assess the change in proportions of diagnoses over time.

Data Sources: Following PRISMA guidelines, systematic searches of PubMed and CINAHL databases and follow-up reference searches were performed for articles published in English up to October 2016.

Study Selection: Analysis of searches yielded 42 studies meeting the criteria of case series of adult patients with dizziness and/or vertigo presenting to general practice, emergency departments or specialist outpatient clinics. Read More

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January 2019
1 Read

Malingering and factitious disorder.

Pract Neurol 2018 Nov 13. Epub 2018 Nov 13.

Nuffield Orthopaedic Hospital, Oxford Centre for Enablement, Oxford, UK.

Although exaggeration or amplification of symptoms is common in all illness, deliberate deception is rare. In settings associated with litigation/disability evaluation, the rate of malingering may be as high as 30%, but its frequency in clinical practice is not known. We describe the main characteristics of deliberate deception (factitious disorders and malingering) and ways that neurologists might detect symptom exaggeration. Read More

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November 2018
11 Reads

Arthrocentesis in the management of internal derangement of the temporomandibular joint.

Aust Dent J 2018 Nov 13. Epub 2018 Nov 13.

Emeritus Professor, Oral& Maxillofacial Surgery Unit, The University of Adelaide, Adelaide, Australia.

Background: Temporomandibular disorders (TMD) cover a wide spectrum of disorder; myalgic, arthralgic and psychogenic. The procedure of TMJ arthrocentesis has a role in managing patients with arthralgic pain and limitation if they fail to respond to non-surgical therapy.

Method: The patient records of a single private specialist OMS were searched over the nine year period of 2006-2014 to identify patients who had arthrocentesis as part of their multidisciplinary management. Read More

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November 2018
4 Reads

[Tourette Syndrome].

Brain Nerve 2018 Nov;70(11):1237-1245

Department of Child and Adolescent Psychiatry, Tokyo Metropolitan Children's Medical Center.

Tourette syndrome (TS) is a neurodevelopmental disorder. TS was formerly considered to be a psychogenic disease; however, TS has recently been thought to be a heterogeneous disease with neurological bases and involving environmental and genetic factors. For example, it has been suggested that neurotransmitters including dopamine and cortico-striato-thalamo-cortical circuits are suggested to be associated with TS pathogenesis. Read More

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November 2018
1 Read

Semiological characteristics of patients with psychogenic nonepileptic seizures: Gender-related differences.

Epilepsy Behav 2018 Dec 8;89:130-134. Epub 2018 Nov 8.

Department of Neurology, Karadeniz Technical University Medical Faculty, 61080 Trabzon, Turkey.

Psychogenic nonepileptic seizures (PNES) are more prevalent among women, and diagnosis may sometimes be delayed by as much as seven years. Understanding the effect of gender on the presentation of a PNES may assist with diagnosis based on semiological details in the clinical setting. Although video-EEG monitoring (VEM) is the gold standard for diagnosing PNES, determining gender-related seizure semiology through careful history may prevent diagnostic delay while waiting for VEM. Read More

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December 2018
3 Reads

[Transient loss of consciousness : Algorithm for the (differential) diagnosis of syncope at emergency department].

Med Klin Intensivmed Notfmed 2018 Nov 9. Epub 2018 Nov 9.

Interdisziplinäre Notaufnahme, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland.

Transient loss of consciousness (TLoC) is a common complaint leading to presentation at the emergency department. This comprises a heterogeneous group of disorders including cerebral events, metabolic disturbances, intoxication, psychogenic patterns or any form of syncope. While many causes are benign and self-limited not requiring extensive in-hospital evaluation, others are potentially severe. Read More

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November 2018
1 Read

Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients.

PLoS One 2018 7;13(11):e0205165. Epub 2018 Nov 7.

Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School, Tokyo, Japan.

Background: There was no available data concerning the clinical differentiation between the updated definition of early chronic pancreatitis (ECP) and anti-acid therapy-resistant functional dyspepsia (RFD).

Aims: We aimed to determine whether clinical symptoms, gastric motility, psychogenic factors and fat intake can help distinguish early chronic pancreatitis (ECP) from anti-acid therapy-resistant functional dyspepsia patients with pancreatic enzyme abnormalities (RFD-P) and anti-acid therapy-resistant functional dyspepsia (RFD) patients using endosonography.

Methods: We enrolled 102 consecutive patients presenting with typical symptoms of RFD patients (n = 52), ECP patients (n = 25) and RFD-P patients (n = 25). Read More

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November 2018
4 Reads

MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: A clinical update.

Eur J Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

R Stoving, Department of Endocrinology and Center for Eating Disorders, Odense University Hospital, Odense, Denmark.

Anorexia nervosa is a syndrome, i.e. collections of symptoms, which it is not defined by etiology. Read More

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October 2018
3 Reads

Optimal recording duration of ambulatory EEG (aEEG).

Epilepsy Res 2018 Aug 3;149:9-12. Epub 2018 Aug 3.

Adult Stanford Comprehensive Epilepsy Center, United States.

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Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy.

EBioMedicine 2018 Nov 2. Epub 2018 Nov 2.

Department of Physiology & Medical Physics, RCSI, Dublin, Ireland; FutureNeuro Research Centre, RCSI, Dublin, Ireland. Electronic address:

Background: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression, mechanistic links to brain excitability, and stable detection in biofluids. Altered levels of circulating microRNAs have been reported in human epilepsy, but most studies collected samples from one clinical site, used a single profiling platform or conducted minimal validation. Read More

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November 2018
4 Reads

ACR Appropriateness Criteria Chronic Dyspnea-Noncardiovascular Origin.

J Am Coll Radiol 2018 Nov;15(11S):S291-S301

Specialty Chair, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Chronic dyspnea may result from a variety of disorders of cardiovascular, pulmonary, gastrointestinal, neuromuscular, systemic, and psychogenic etiology. This article discusses guidelines for the initial imaging of six variants for chronic dyspnea of noncardiovascular origin: (1) Chronic dyspnea of unclear etiology; (2) Chronic dyspnea with suspected chronic obstructive pulmonary disease; (3) Chronic dyspnea with suspected central airways disease; (4) Chronic dyspnea with suspected interstitial lung disease; (5) Chronic dyspnea with suspected disease of the pleura or chest wall; and (6) Chronic dyspnea with suspected diaphragm dysfunction. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. Read More

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November 2018
4 Reads

Dual diagnosis of epilepsy and psychogenic nonepileptic seizures: Systematic review and meta-analysis of frequency, correlates, and outcomes.

Epilepsy Behav 2018 Dec 29;89:70-78. Epub 2018 Oct 29.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Comorbid epilepsy and psychogenic nonepileptic seizures (PNES) represent a serious challenge for the clinicians. However, the frequency, associations, and outcomes of dual diagnosis of epilepsy and PNES are unclear. The aim of the review was to determine the frequency, correlates, and outcomes of a dual diagnosis. Read More

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December 2018
2 Reads

Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders.

J Neuropsychiatry Clin Neurosci 2018 Oct 31:appineuropsych18040095. Epub 2018 Oct 31.

From the Department of Neurology, Functional Neurology Research Group, Cognitive Behavioral Neurology Unit, Massachusetts General Hospital, Harvard Medical School, Boston (BW, JPO, RJ, DLP); the Department of Psychiatry, Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston (GLF); and the Department of Psychiatry, Neuropsychiatry Unit, Massachusetts General Hospital, Harvard Medical School, Boston (DLP).

Insecure attachment is a predisposing risk factor for the development of functional neurological disorder (FND). There is limited research investigating connections between attachment styles, other predisposing vulnerabilities, and symptom severity in patients with motor FND. By using a within-group design with prospective data collection, the authors performed univariate tests followed by multivariate linear regressions to investigate neuropsychiatric factors associated with four attachment styles (secure, fearful, preoccupied, and dismissing) among 56 patients with motor FND (mean age=40. Read More

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October 2018
6 Reads

Multi-profile procedures for motor conversion disorders in children - a case report.

Psychiatr Pol 2018 Aug 24;52(4):685-695. Epub 2018 Aug 24.

Zakład Rehabilitacji, Wydział Medyczny Uniwersytetu Rzeszowskiego.

Objectives: The most common motor deficits in patients with conversion disorder are tremors, weakness of limbsand gait disturbance. The proper diagnosis and treatment aswell as the patient and their family's cooperation during therapy are essential to achieve fast recovery. The aim of this paper is to provide an overview of multidisciplinary interventions successfully applied in the treatment of conversion disorders in children, illustrated with an example of a case study. Read More

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August 2018
5 Reads

Benefits of additional cardiologic examination in patients admitted for differential diagnosis to the Epilepsy Center Bethel.

Epilepsy Res 2018 Dec 16;148:44-47. Epub 2018 Oct 16.

Epilepsy Center Bethel, Krankenhaus Mara, Bielefeld, Germany.

Additional cardiologic examination for syncope is used for patients admitted for diagnostic reasons in the Epilepsy Center Bethel if, after epileptologic examination, the etiology of seizures remains uncertain and a cardiologic etiology is suspected. Therefore, we retrospectively analyzed all patient data from the diagnostic department between 02/2011 and 07/2015 to evaluate the benefits to patients of additional cardiologic examination for syncope. 78 out of 1567 patients underwent additional cardiologic examination for syncope. Read More

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December 2018
1 Read

Complex regional pain syndrome and functional neurological disorders: time for reconciliation.

J Neurol Neurosurg Psychiatry 2018 Oct 24. Epub 2018 Oct 24.

Centre for Clinical Brain Sciences, Western General Hospital, NHS Lothian and University of Edinburgh, Edinburgh, UK

There have been many articles highlighting differences and similarities between complex regional pain syndrome (CRPS) and functional neurological disorders (FND) but until now the discussions have often been adversarial with an erroneous focus on malingering and a view of FND as 'all in the mind'. However, understanding of the nature, frequency and treatment of FND has changed dramatically in the last 10-15 years. FND is no longer assumed to be only the result of 'conversion' of psychological conflict but is understood as a complex interplay between physiological stimulus, expectation, learning and attention mediated through a Bayesian framework, with biopsychosocial predisposing, triggering and perpetuating inputs. Read More

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October 2018
5 Reads

Postseizure aphasia in Wernicke's encephalopathy: a case report and review of literature.

Neuropsychiatr Dis Treat 2018 8;14:2593-2598. Epub 2018 Oct 8.

Department of Psychiatry, Consultation-Liaison Psychiatry, Loyola University Medical Center, Maywood, IL 60153, USA,

This case discusses the course of a woman with a history of epilepsy, alcohol use disorder, herpes simplex virus (HSV) encephalitis, and Wernicke encephalopathy (WE) who presented with altered mental status following approximately 48 hours of vomiting. After experiencing a tonic-clonic seizure in the emergency department, she developed a fluent aphasia. Aphasias are ordinarily attributed to structural changes in the brain parenchyma, often from stroke, neoplasm, or infection. Read More

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October 2018
9 Reads

The effectiveness and acceptability of a guided self-help Acceptance and Commitment Therapy (ACT) intervention for psychogenic nonepileptic seizures.

Epilepsy Behav 2018 Nov 17;88:332-340. Epub 2018 Oct 17.

Trent Doctorate in Clinical Psychology, University of Lincoln, Brayford Wharf East, Lincoln LN5 7AY, UK.

This study utilized a nonconcurrent case-series design to examine the effectiveness and acceptability of a guided self-help Acceptance and Commitment Therapy (ACT) intervention for people with psychogenic nonepileptic seizures. A key aim of the study was to investigate the relationship between psychological flexibility (a key process within ACT), psychological health, quality of life, and seizure frequency. Six participants completed the study, with reliable and clinically significant changes in psychological flexibility, quality of life, and psychological health observed in the majority of participants. Read More

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November 2018
3 Reads

Secure Attachment and Depression Predict 6-Month Outcome in Motor Functional Neurological Disorders: A Prospective Pilot Study.

Psychosomatics 2018 Aug 29. Epub 2018 Aug 29.

Department of Neurology, Functional Neurology Research Group, Cognitive Behavioral Neurology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry, Neuropsychiatry Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:

Background: The relationships between baseline neuropsychiatric factors and clinical outcome in patients with functional neurological disorder (FND)/conversion disorder remain poorly understood.

Objective: This prospective, naturalistic pilot study investigated links between predisposing vulnerabilities (risk factors) and clinical outcome in patients with motor FND engaged in usual care within a subspecialty FND clinic.

Methods: Thirty-four patients with motor FND were enrolled and completed baseline and 6-month follow-up psychometric questionnaires. Read More

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August 2018
1 Read

Cardiovascular Autonomic Profile in Women With Premenstrual Syndrome.

Front Physiol 2018 1;9:1384. Epub 2018 Oct 1.

Department of Internal Medicine F, J. Recanati Autonomic Dysfunction Center, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

The premenstrual syndrome (PMS) is a constellation of somatic and psychogenic symptoms that appear during late luteal (LL) phase of the menstrual cycle. Since many symptoms could be related to the autonomic nervous system, we hypothesized that the sympathetic nervous system is perturbed in PMS. The cardiovascular autonomic profile of nine women with PMS (30. Read More

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October 2018
5 Reads

Consensus on diagnosis and management of psychogenic non-epileptic seizures: a wide view of a challenging condition.

Authors:
F Brigo S Lattanzi

Eur J Neurol 2018 Oct 16. Epub 2018 Oct 16.

Neurological Clinic, Marche Polytechnic University, Ancona, Italy.

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October 2018
12 Reads

Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats.

Neuroscience 2018 Nov 12;393:273-283. Epub 2018 Oct 12.

Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, Brazil. Electronic address:

Chronic psychogenic stress can increase neuronal calcium influx and generate the intracellular accumulation of oxidative (ROS) and nitrosative (RNS) reactive species, disrupting synaptic transmission in the brain. These molecules impair the Na,K-ATPase (NKA) activity, whose malfunction has been related to neuropsychiatric disorders, including anxiety, depression, schizophrenia, and neurodegenerative diseases. In this study, we assessed how 14 days of restraint stress in rats affect NKA activity via oxidative/nitrosative damage in the frontal cortex (FCx), a crucial region for emotional and cognitive control. Read More

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November 2018
3.360 Impact Factor

Can home videos made on smartphones complement video-EEG in diagnosing psychogenic nonepileptic seizures?

Seizure 2018 Nov 3;62:95-98. Epub 2018 Oct 3.

All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Purpose: To assess the contribution home-videos made on mobile phones can make to the diagnosis of Psychogenic Nonepileptic Seizures (PNES).

Methods: Consecutive patients 10-50 years old, with episodes of altered behavior or abnormal movements, unresponsiveness, or falls, were recruited after they had obtained 'good' or 'fair' quality (quality of video scale (QOV)) home-videos of their episodes on personal mobile phones; these subjects underwent video-electroencephalography (VEEG). Diagnoses of PNES, other physiological events or epileptic seizure (ES) on home-videos (by the epilepsy fellow, step 1) and on VEEGs (by a fully trained epileptologist unaware of the home-video recording, step 2) were compared. Read More

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November 2018
1 Read

Subjective and physiological response to emotions in temporal lobe epilepsy and psychogenic non-epileptic seizures.

J Affect Disord 2019 Feb 5;244:46-53. Epub 2018 Oct 5.

Service de Neurophysiologie Clinique, Centre Hospitalo Universitaire de la Timone, 264, rue Saint-Pierre, Marseille 13005, France; Aix Marseille University, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.

Background: Temporal lobe epilepsy (TLE) and psychogenic non-epileptic seizures (PNES) are conditions frequently associated with dysfunction in emotional regulation leading to increased risk of affective disorders. This study investigates emotional processing with an objective measure of emotional reactivity in patients with TLE and patients with PNES.

Methods: 34 patients with TLE and 14 patients with PNES were evaluated on skin conductance responses (SCR) to emotions induced by short films and compared to 34 healthy controls. Read More

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February 2019
1 Read

Management of psychogenic non-epileptic seizures: a multidisciplinary approach.

Eur J Neurol 2018 Oct 9. Epub 2018 Oct 9.

Department of Medical and Surgical Sciences, Magna Greacia University of Catanzaro, Catanzaro, Italy.

The International League against Epilepsy (ILAE) proposed a diagnostic scheme for psychogenic non-epileptic seizure (PNES). The debate on ethical aspects of the diagnostic procedures is ongoing, the treatment is not standardized and management might differ according to age group. The objective was to reach an expert and stakeholder consensus on PNES management. Read More

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October 2018
5 Reads

The clinical features and outcome of scan-negative and scan-positive cases in suspected cauda equina syndrome: a retrospective study of 276 patients.

J Neurol 2018 Dec 8;265(12):2916-2926. Epub 2018 Oct 8.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Background: The majority of patients presenting with suspected clinical cauda equina syndrome (CES) have no identifiable structural cause for their symptoms ('scan-negative' CES). Understanding these patients aids clinical differentiation and management in CES.

Methods: A retrospective electronic note review was undertaken of patients presenting with suspected CES, defined as ≥ 1 of acute bladder, bowel, sexual dysfunction or saddle numbness, to a regional neurosciences centre. Read More

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December 2018
2 Reads

A case of psychogenic Parkinsonism: Late age of onset should not be a barrier to make the diagnosis.

Aust N Z J Psychiatry 2018 Nov 8;52(11):1098. Epub 2018 Oct 8.

2 Academic Unit of Psychiatry and Addiction Medicine and College of Medicine, Biology, and Environment, ANU Medical School, Canberra, ACT, Australia.

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November 2018
7 Reads

Narrative analysis of written accounts about living with epileptic or psychogenic nonepileptic seizures.

Seizure 2018 Nov 28;62:59-65. Epub 2018 Sep 28.

Academic Neurology Unit, University of Sheffield, UK. Electronic address:

Purpose: This study is based on a narrative analysis of individuals' written accounts of living with epilepsy (n = 29) or psychogenic non-epileptic seizures (n = 20, PNES). Narrative analysis looks at both the content and structure of the personal account. We used a form of narrative analysis that allowed us to identify common story lines, otherwise known as narrative typologies, potentially characteristic of these patient groups. Read More

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November 2018
6 Reads

Functional movement disorders of the face: A historical review and case series.

J Neurol Sci 2018 Dec 26;395:35-40. Epub 2018 Sep 26.

Centre for Clinical Brain Sciences, University of Edinburgh, Dept Clinical Neurosciences, Western General Hospital, Edinburgh, UK; Department of Rehabilitation Medicine, NHS Lothian, Edinburgh, UK.

Functional facial dystonia or spasm has, in recent years, been recognised as a relatively common form of functional movement disorder. We describe historical 'forgotten' neurological literature indicating that this was a well described phenomenon in the late 19th and early 20th century but subsequently faded from awareness. We add data from our own series of 41 patients with functional facial dystonia to explore the clinical features and associated comorbidities of patients with this movement disorder. Read More

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December 2018
2 Reads

Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food.

Diabetes 2018 Oct 2. Epub 2018 Oct 2.

Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, WC1E 6BT, UK

Centrally administered glucagon-like peptide-1 (GLP-1) supresses food intake. Here we demonstrate that GLP-1-producing (PPG) neurons in the nucleus tractus solitarii (NTS) are the predominant source of endogenous GLP-1 within the brain. Selective ablation of NTS PPG neurons by viral expression of diphtheria toxin subunit A (DTA) substantially reduced active GLP-1 concentrations in brain and spinal cord. Read More

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October 2018
4 Reads

Provocative induction of psychogenic nonepileptic seizures: Noninferiority of an induction technique without versus with placebo.

Epilepsia 2018 Nov 1;59(11):e161-e165. Epub 2018 Oct 1.

Neurology Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.

We aim to demonstrate, in a sufficiently powered and standardized study, that the success rate of inducing psychogenic nonepileptic seizures (PNES) without placebo (saline infusion) is noninferior to induction with placebo. The clinical data of 170 consecutive patients with suspected PNES who underwent induction with placebo from January 21, 2009 to March 31, 2013 were pair-matched with 170 consecutive patients with suspected PNES who underwent the same induction technique but without addition of placebo from April 1, 2013 to February 7, 2018 at the same center. The success rates of induction were 79. Read More

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November 2018
4 Reads

Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus.

Aging Dis 2018 Oct 1;9(5):817-830. Epub 2018 Oct 1.

1Clinical Pharmacology, Goethe-University Hospital Frankfurt am Main, Germany.

Loss-of-function mutations of progranulin are associated with frontotemporal dementia in humans, and its deficiency in mice is a model for this disease but with normal life expectancy and mild cognitive decline on aging. The present study shows that aging progranulin deficient mice develop progressive polydipsia and polyuria under standard housing conditions starting at middle age (6-9 months). They showed high water licking behavior and doubling of the normal daily drinking volume, associated with increased daily urine output and a decrease of urine osmolality, all maintained during water restriction. Read More

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October 2018
5 Reads

A New Intraoral Appliance for Trismus in Oral Submucous Fibrosis.

Case Rep Dent 2018 9;2018:1039391. Epub 2018 Sep 9.

Department of Orthodontics and Dentofacial Orthopedics, Panineeya Institute of Dental Sciences, Hyderabad, India.

Trismus is the most common sequelae of various pathological processes leading to compromised nutritional state in addition to physical and psychological disabilities. Therapeutic interventions are available to relieve trismus, which range from oral usage of pharmacological agents to intralesional steroid therapy. Intraoral appliance therapy can be employed as an alternative or adjuvant treatment for radiotherapy-induced fibrosis and autoimmune disorders such as scleroderma, psychogenic trismus, and oral submucous fibrosis, decreasing the adverse effects associated with other pharmacological interventions. Read More

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September 2018
7 Reads

The application of artificial intelligence to understand the pathophysiological basis of psychogenic nonepileptic seizures.

Epilepsy Behav 2018 Sep 28. Epub 2018 Sep 28.

Italy Institutes of Neurology, Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy. Electronic address:

Psychogenic nonepileptic seizures (PNES) are episodes of paroxysmal impairment associated with a range of motor, sensory, and mental manifestations, which perfectly mimic epileptic seizures. Several patterns of neural abnormalities have been described without identifying a definite neurobiological substrate. In this multicenter cross-sectional study, we applied a multivariate classification algorithm on morphological brain imaging metrics to extract reliable biomarkers useful to distinguish patients from controls at an individual level. Read More

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September 2018
5 Reads