12,544 results match your criteria Psychiatry Research: Neuroimaging [Journal]


Markers of neuroinflammation influence measures of cortical thickness in bipolar depression.

Psychiatry Res Neuroimaging 2019 Jan 29;285:64-66. Epub 2019 Jan 29.

Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milano, Italy.

We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.009DOI Listing
January 2019

Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers.

Psychiatry Res Neuroimaging 2019 Feb 10;285:58-63. Epub 2019 Feb 10.

Department of Psychology & Neuroscience, University of Colorado Boulder, 345 UCB, Boulder, CO, United States.

Exploring associations among cannabis use, brain structure, and cognitive function in older adults offers an opportunity to observe potential harm or benefit of cannabis. This pilot study assessed structural magnetic resonance imaging in older adults who were either current cannabis users (n = 28; mean age 69.8 years, 36% female) or nonusers (n = 28; mean age 66. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.02.001DOI Listing
February 2019

Neural and cognitive correlates of stigma and social rejection in individuals with Serious Mental Illness (SMI): A systematic review of the literature.

Authors:
Dubreucq J Franck N

Psychiatry Res 2019 Feb 11;274:146-158. Epub 2019 Feb 11.

Centre de Neurosciences Cognitive, UMR 5229, CNRS & Université Lyon 1, France; Réseau Handicap Psychique, Grenoble, France; Centre Référent Lyonnais de Réhabilitation Psychosociale et de Remédiation Cognitive (CL3R), Centre Hospitalier Le Vinatier, France; Centre Ressource de Réhabilitation Psychosociale et de Remédiation Cognitive, Centre Hospitalier Le Vinatier, France.

Stigma and self-stigma are major issues for people with Serious Mental Illness (SMI). This review's aims were to determine the cognitive and neural processes underlying the effects of stigma and social rejection in people with SMI. A stepwise systematic literature review (PRISMA) was conducted by searching PubMed, Medline and Web of Science using the following keywords: "cyberball" OR "stereotype threat" OR "implicit association test" AND "mental illness". Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.023DOI Listing
February 2019

The influence of depressive symptoms on executive functioning in binge eating disorder: A comparison of patients and non-obese healthy controls.

Psychiatry Res 2019 Feb 15;274:138-145. Epub 2019 Feb 15.

Rivierduinen Eating Disorders Ursula, Leiden, the Netherlands; Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.

Executive functions are a set of cognitive processes that are necessary for the cognitive control of behavior. They play a role in mediating self-control, self-regulation and decision-making. It has been suggested that the inability to control eating behavior in binge eating disorder (BED) may indicate deficits in executive functioning. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.033DOI Listing
February 2019

Direct comparisons of anorexia nervosa and body dysmorphic disorder: A systematic review.

Psychiatry Res 2019 Feb 1;274:129-137. Epub 2019 Feb 1.

Centre for Mental Health, Swinburne University of Technology, Melbourne, Australia; Department of Mental Health, St Vincent's Hospital, Melbourne, Australia.

Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are serious psychiatric conditions, both of which are associated with a disturbance of body image. The aim of this paper was to review those studies that have directly compared groups of individuals with AN and BDD, to determine similarities and differences in presentation between the two conditions. The literature was searched to September 2018, and studies were included if they were English language, empirical research papers published in peer-reviewed journals, specifically comparing AN and BDD patients. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.106DOI Listing
February 2019

Factors associated with completing evidence-based psychotherapy for PTSD among veterans in a national healthcare system.

Psychiatry Res 2019 Feb 11;274:112-128. Epub 2019 Feb 11.

Mental Health Service, White River Junction VA Medical Center, and National Center for Posttraumatic Stress Disorder, Executive Division, White River Junction, VT, USA; Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Little is known about predictors of initiation and completion of evidence-based psychotherapy (EBP) for posttraumatic stress disorder (PTSD), with most data coming from small cohort studies and post-hoc analyses of clinical trials. We examined patient and treatment factors associated with initiation and completion of EBP for PTSD in a large longitudinal cohort. We conducted a national, retrospective cohort study of all Iraq and Afghanistan War veterans who had a post-deployment PTSD diagnosis from 10/01-9/15 at a Veterans Health Administration facility and had at least one coded post-deployment psychotherapy visit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183169
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http://dx.doi.org/10.1016/j.psychres.2019.02.027DOI Listing
February 2019
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Posttraumatic stress disorder and traumatic brain Injury: Sex differences in veterans.

Psychiatry Res 2019 Jan 31;274:105-111. Epub 2019 Jan 31.

Salisbury VA Health Care System, 1601 Brenner Ave, Salisbury, NC 28144, USA; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), 508 Fulton St, Durham, NC 27705, USA; Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. Electronic address:

Around half of Iraq and Afghanistan war veterans with traumatic brain injury (TBI) have co-occurring posttraumatic stress disorder (PTSD). Research on the differences between male and female veterans with co-occurring PTSD/TBI is sparse. This study evaluated behavioral health differences between sexes with these conditions. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.097DOI Listing
January 2019

Testing helping behavior and its relationship to antisocial personality and psychopathic traits.

Psychiatry Res 2019 Feb 11;274:98-104. Epub 2019 Feb 11.

Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA.

When presented with decisions that require simultaneously weighing self-benefit and other harm, adolescents with callous-unemotional traits compared with controls engage in less Costly Helping (i.e., giving up a benefit to protect a beneficent other). Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.022DOI Listing
February 2019

The unique associations between self-compassion and eating disorder psychopathology and the mediating role of rumination.

Psychiatry Res 2019 Feb 8;274:91-97. Epub 2019 Feb 8.

Department of Psychology, The College of New Jersey, Ewing, NJ, United States.

Mindfulness reduces eating disorder (ED) psychopathology. Self-compassion is a related but distinct construct that may predict other clinical outcomes more strongly than does mindfulness. Previous evidence suggests that self-compassion is associated with less ED psychopathology, although no studies have compared the unique effects of self-compassion and mindfulness. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.019DOI Listing
February 2019

Are subsyndromal manifestations of attention deficit hyperactivity disorder morbid in children? A systematic qualitative review of the literature with meta-analysis.

Psychiatry Res 2019 Feb 3;274:75-90. Epub 2019 Feb 3.

Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address:

We conducted a qualitative review (n = 15 manuscripts) and meta-analysis (n = 9 manuscripts) of the extant literature to evaluate the prevalence and morbidity of subthreshold Attention Deficit Hyperactivity Disorder (ADHD). Our qualitative review showed that a sizable minority (mean: 17.7%) of clinically referred and non-referred children met a priori definitions of subthreshold ADHD. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.003DOI Listing
February 2019

Association between sleep quality and metabolic syndrome: A systematic review and meta-analysis.

Psychiatry Res 2019 Feb 1;274:66-74. Epub 2019 Feb 1.

Center for Data Science in Health and Medicine, Qianfoshan Hospital Affiliated to Shandong University, Jinan, China. Electronic address:

Sleep quality has been suggested to play an important role in development of metabolic syndrome (MetS). However, the results have been inconsistent. A systematic review of observational studies aimed to evaluate the association between sleep quality and MetS. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.096DOI Listing
February 2019

Sexual dysfunction and hyperprolactinemia in schizophrenia before and after six weeks of D receptor blockade - An exploratory study.

Psychiatry Res 2019 Feb 8;274:58-65. Epub 2019 Feb 8.

Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Denmark.

Sexual side-effects along with antipsychotic treatment may be linked to hyperprolactinemia and dopamine D receptor blockade. High prevalence of sexual dysfunction in un-medicated patients challenges the notion of sexual dysfunction as merely a side-effect of antipsychotic medication. Sexual dysfunction was assessed in fifty-six initially antipsychotic-naïve patients with schizophrenia using the UKU (Udvalget for Kliniske Undersøgelser) questionnaire. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.017DOI Listing
February 2019

Salivary melatonin onset in youth at familial risk for bipolar disorder.

Psychiatry Res 2019 Feb 6;274:49-57. Epub 2019 Feb 6.

Department of Psychiatry, University of Michigan, Ann arbor, MI, United States.

Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR). Adolescent participants (n = 12) were a mean age 14 ± 2.3 years and included 8 females and 4 males. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.013DOI Listing
February 2019

Cannabis use and violence in patients with severe mental illnesses: A meta-analytical investigation.

Psychiatry Res 2019 Feb 6;274:42-48. Epub 2019 Feb 6.

Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, Montreal, Canada; Institut national de psychiatrie légale Philippe-Pinel, Montreal, Canada. Electronic address:

Background: The relationship between cannabis and violence remains unclear, especially amid those with severe mental illnesses (SMI). The objective of this meta-analysis was to investigate the cannabis-violence association in a population of individuals with a SMI.

Method: A systematic search of literature using PubMed, PsychINFO, Web of Science and Google scholar was performed (any time-August 2018). Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.010DOI Listing
February 2019

The impact of age on the validity of psychosis-risk screening in a sample of help-seeking youth.

Psychiatry Res 2019 Feb 10;274:30-35. Epub 2019 Feb 10.

Human Services Psychology Department, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address:

Self-report screening instruments offer promise in furthering early identification of at-risk youth, yet current efforts are limited by false positive rates. Identifying moderators of accuracy is a potential step towards improving identification and prevention efforts. We investigated the moderating effect of age on self-reported attenuated positive symptoms from the Prime Screen and clinician diagnosed clinical high-risk/early psychosis (CHR/EP) status. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.020DOI Listing
February 2019

The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 Feb 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
February 2019

Autistic traits impact on olfactory processing in adolescent girls with Anorexia Nervosa restricting type.

Psychiatry Res 2019 Feb 11;274:20-26. Epub 2019 Feb 11.

IRCCS Fondazione Stella Maris, Pisa, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

The correct functioning of the chemosensory pathway is pivotal for the attitude towards feeding. In some neuropsychiatric disorders, abnormalities of the sensory processing dramatically affect feeding behavior; however, evidences for an olfactory involvement in Anorexia Nervosa (AN) are still controversial. We administered a complete olfactory testing battery, the Sniffin' Sticks Extended Test, to a cohort of 19 girls with Restrictive Anorexia Nervosa (AN-R) and 19 healthy controls. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.026DOI Listing
February 2019
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Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure.

Psychiatry Res Neuroimaging 2018 Dec 24;285:51-57. Epub 2018 Dec 24.

Melbourne Neuropsychiatry Center, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

Prior research indicates that socioeconomic disadvantage is associated with prefrontal cortical (PFC) development in childhood and adolescence, however the mechanisms of this link are unclear. This study investigated whether DNA methylation of the brain-derived neurotrophic factor (BDNF, which plays a key role in synaptic plasticity), mediated the association between neighborhood disadvantage and thickness of the PFC in adolescents. Neighborhood disadvantage was measured in 33 adolescents aged 12-13 years using the Socio-Economic Indexes for Areas. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2018.12.012DOI Listing
December 2018
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Magnetic resonance imaging predictors of psychotherapy treatment response in post-traumatic stress disorder: A role for the salience network.

Psychiatry Res 2019 Feb 2. Epub 2019 Feb 2.

James J. Peters VA Medical Center, Bronx, NY, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

The earliest neuroimaging studies in post-traumatic stress disorder (PTSD) utilized positron emission tomography (PET) to examine the brain's response to glucocorticoid administration given predominant neurobiological models of the stress response focusing on that neuroendocrine system. This work revealed that the anterior cingulate cortex and amygdala, which is now considered part of the salience network, play a role in treatment response, and set the stage for subsequent magnetic resonance (MR) imaging studies focused on understanding the role of the salience network in the neurobiology of treatment response in PTSD. This selective review discusses magnetic resonance (MR) imaging studies that have been used to predict treatment response to cognitive-behavioral therapy (CBT) or prolonged exposure (PE) in PTSD, which have demonstrated abnormalities in processing involving the salience network, including the amygdala, anterior cingulate cortex and insula. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.005DOI Listing
February 2019

Hypogyrification and its association with cognitive impairment in children with 22q11.2 deletion Syndrome: A preliminary report.

Psychiatry Res Neuroimaging 2019 Jan 31;285:47-50. Epub 2019 Jan 31.

Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

22q11.2 Deletion Syndrome (22qDS) is a neurogenetic disorder resulting in cognitive deficits and hypogyrification, but relationships between these processes have not been established. 22qDS youth and healthy controls (HC) were administered a battery of cognitive tasks. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.007DOI Listing
January 2019
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Rates and predictors of one-year antipsychotic treatment discontinuation in first-episode schizophrenia: Results from an open-label, randomized, "real world" clinical trial.

Psychiatry Res 2019 Jan 24;273:631-640. Epub 2019 Jan 24.

Institute of Mental Health, Peking University, Huayuanbei 51, Haidian District, Beijing, 100191, China. Electronic address:

Antipsychotic treatment discontinuation is a major challenge in the treatment of first-episode schizophrenia (FES) patients. However, the rate and predictors remain unclear. Five hundred and sixty-nine FES patients were randomized to risperidone (n = 190), olanzapine (n = 185) or aripiprazole (n = 194) in a six-site study in China with 1-year follow-up. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183078
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http://dx.doi.org/10.1016/j.psychres.2019.01.068DOI Listing
January 2019
5 Reads

Sleep-disordered breathing and Alzheimer's disease: A nationwide cohort study.

Psychiatry Res 2019 Jan 28;273:624-630. Epub 2019 Jan 28.

Department of Preventive Medicine and Public Health, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address:

Sleep-disordered breathing (SDB) is common and can lead to significant cognitive decline, such as Alzheimer's disease (AD). Therefore, the present study was conducted to investigate whether SDB is associated with AD onset. This study used the nationwide health check-up cohort data between 2002 and 2015. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.086DOI Listing
January 2019
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Predictors of functional improvement in children and adolescents at a publicly funded specialist outpatient treatment clinic in a Canadian Prairie City.

Psychiatry Res 2019 Jan 30;273:613-623. Epub 2019 Jan 30.

Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada; Douglas Mental Health University Institute, Montreal, QC, Canada.

Children's mental health problems substantially impact their functioning. For clinically treated children and adolescents, we explored the impact of mental health treatment on functioning and identified predictors of functional improvement. Outpatient clinical data from a regional publicly funded specialist outpatient treatment clinic were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183173
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http://dx.doi.org/10.1016/j.psychres.2019.01.093DOI Listing
January 2019
2 Reads

How to help homeless youth suffering from first episode psychosis and substance use disorders? The creation of a new intensive outreach intervention team.

Psychiatry Res 2019 Jan 27;273:603-612. Epub 2019 Jan 27.

Department of Psychiatry, Université de Montréal, 2900 Boulevard Edouard Montpetit, Montréal, QC, Canada, QC H3T 1J4; Centre hospitalier de l'Université de Montréal (CHUM) - 1000, rue St-Denis, Montréal, QC, Canada, H2X 0C1; Centre de recherche du CHUM, 900, rue St-Denis, Montréal, QC, Canada, H2X 0A9. Electronic address:

In Canada, about 6,000 youth are homeless every night, many of whom suffer from addiction and psychotic disorders. To facilitate the exit out of homelessness, access to care and to improve psychosis and addiction outcomes, a new intensive outreach intervention team (EQIIP SOL) was created in Montreal (2012). It offers intensive outreach services dedicated to homeless youth suffering from first episode psychosis and addiction (HYFEPA) in addition to an early psychosis intervention service (EIS) in collaboration with the Addiction Psychiatry Unit. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.076DOI Listing
January 2019
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Corticostriatal-limbic correlates of sub-clinical obsessive-compulsive traits.

Psychiatry Res Neuroimaging 2019 Jan 30;285:40-46. Epub 2019 Jan 30.

Organization for Promotion of Neurodevelopmental Disorder Research, Kyoto, Japan; Faculty of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Obsessive-compulsive (OC) traits such as intrusive worrisome ideas or excessive concerns for threats are frequent in general population (5%-13%). However, the structural neural correlates of the sub-clinical OC traits remain largely unknown. Based on the data of obsessive-compulsive disorder (OCD), we hypothesized that the subcortical and cortical structures, constituting the cortico-striatal-thalamo-cortical circuit (CSTC) and the limbic system, could be associated with OC traits. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.012DOI Listing
January 2019
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Emotion identification among people with serious mental illnesses: The role of specific emotions and sex.

Psychiatry Res 2019 Jan 27. Epub 2019 Jan 27.

Department of Community Mental Health, Faculty of Social Welfare and Health Sciences, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, Israel; Department of Clinical Medicine, Psychiatry, Aalborg University, Denmark.

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http://dx.doi.org/10.1016/j.psychres.2019.01.082DOI Listing
January 2019

Forty years of editorship of psychiatry research.

Psychiatry Res 2019 Jan 26. Epub 2019 Jan 26.

Psychiatry and Radiology, University of California, Sorrento Valley Road, 11388 San Diego, USA; Distinguished Professor Emeritus of Psychiatry and Radiology, University of California, San Diego and Professor Emeritus, University of California, Irvine 1455 Coral Drive, Laguna Beach California, USA. Electronic address:

The astonishing 20 fold growth of the yearly published psychiatric research literature over the past four decades has been paralleled and facilitated by the internet application of electronic publishing. This personal history highlights the decade by decade 1978-2018 augmentation and erosion of this interelationship from the founding of Psychiatry Research to the present day. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.071DOI Listing
January 2019

Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease.

Psychiatry Res 2019 Jan 26. Epub 2019 Jan 26.

Department of Psychiatry, University of Szeged, 57 Kálvária Ave, Szeged, H-6724 Hungary.

The ATP-binding cassette, sub-family A, member 7 (ABCA7) gene has been identified as a strong genetic risk locus for Alzheimer's disease (AD). Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants. A modest, marginally significant association of the G allele containing genotypes with AD was observed (p = 0. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.081DOI Listing
January 2019
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Successful publishing of research: An editor's view.

Authors:
Lynn E DeLisi

Psychiatry Res 2019 Jan 29. Epub 2019 Jan 29.

VA Boston Healthcare System, Harvard Medical School, 940 Belmont Avenue, Brockton, MA 02310, United States. Electronic address:

Authors often are frustrated by responses they receive from editors when their manuscripts are rejected and do not understand from an editor's view what is needed to successfully publish their work. Editors receive sometimes several manuscripts a day and have to develop methods to screen out the ones that are likely not to pass the review process. They also want papers to be able to be written in such a way that it is clear why the studies of which they report are important and novel and worth publishing. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.087DOI Listing
January 2019

Neural markers of depression risk predict the onset of depression.

Psychiatry Res Neuroimaging 2019 Jan 25;285:31-39. Epub 2019 Jan 25.

Child Cognitive Behavioral Therapy Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02215, USA.

Although research highlights neural correlates of Major Depressive Disorder (MDD), it is unclear whether these correlates reflect the state of depression or a pre-existing risk factor. The current study examined whether baseline differences in brain activations, resting-state connectivity, and brain structural differences between non-symptomatic children at high- and low-risk for MDD based on familial depression prospectively predict the onset of a depressive episode or increases in depressive symptomatology. We re-assessed 44 participants (28 high-risk; 16 low-risk) who had undergone neuroimaging in a previous study 3-4 years earlier (Mean age at follow-up = 14. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.006DOI Listing
January 2019
2 Reads

Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS).

Psychiatry Res Neuroimaging 2019 Jan 30;285:25-30. Epub 2019 Jan 30.

Department of Neuropsychiatry, School of Medicine, Toho University, 6-11-1 Omori-nishi, Ota-ku, 143-8541, Tokyo, Japan.

Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated with changes in the striatum. We investigated if structural changes in the striatum are associated with recovery of sub-threshold psychotic symptoms in subjects with an ARMS who did not develop psychosis (ARMS-N). Sixteen healthy controls and 42 subjects with an ARMS participated in this study. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.008DOI Listing
January 2019

The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with Tc-HMPAO SPECT.

Psychiatry Res Neuroimaging 2019 Jan 16;285:18-24. Epub 2019 Jan 16.

Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, East Flanders, Belgium.

Subanaesthetic ketamine has recently been established as an effective and rapid treatment for major depressive disorder showing antidepressant effects for up to 1 week on average. The use of repeated ketamine infusions has been put forward to augment and to prolong the antidepressant response and increase the remission rates. The underlying neurobiological mechanisms responsible for ketamine's antidepressant effects remain unclear. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.005DOI Listing
January 2019
1 Read

Congruence and discrepancy between self-rated and clinician-rated symptom severity on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) before and after a low-intensity intervention.

Psychiatry Res 2019 Jan 29;273:595-602. Epub 2019 Jan 29.

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. Electronic address:

The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is the most common measure of Obsessive-Compulsive symptom severity. The Y-BOCS interview is considered gold standard, but its self-rating format is increasingly used in clinical trials. Few studies investigated congruency and potential changes over treatment. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.092DOI Listing
January 2019
2 Reads

Randomized controlled trial of cognitive-motivational therapy program (PIPE) for the initial phase of schizophrenia: Maintenance of efficacy at 5-year follow up.

Psychiatry Res 2019 Jan 28;273:586-594. Epub 2019 Jan 28.

Department of Mental health, Hospital de Mataró, Carretera de Cirera s/n (08304), Barcelona Spain.

Aim: The main goal of this study was to evaluate the effectiveness of a cognitive motivational treatment program.

Method: A randomized, controlled, single-blind clinical trial was carried out. A total of 104 patients were recruited to take part in the trial, of whom ultimately 62 patients were allocated into two groups and finished the study. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.084DOI Listing
January 2019
1 Read

Mental illness stigma among Pacific Islanders.

Psychiatry Res 2019 Jan 26;273:578-585. Epub 2019 Jan 26.

University of California, Riverside School of Public Policy, 900 University Ave, Riverside, CA 92521, USA.

Native Hawaiians and other Pacific Islanders (NHPI) rarely seek mental health treatment for reasons that are minimally understood. To assess the mental illness stigma context in NHPI communities that may be contributing to low help-seeking, this study collected novel stigma data from two large U.S. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.077DOI Listing
January 2019
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Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders.

Psychiatry Res 2019 Jan 29;273:575-577. Epub 2019 Jan 29.

Genetics Division of the Department of Morphology and Genetics, Universidade Federal de São Paulo (UNIFESP), Brazil; Interdisciplinary Laboratory of Clinical Neurosciences (LiNC), UNIFESP, Brazil; Department of Psychiatry, UNIFESP, Brazil. Electronic address:

We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.078DOI Listing
January 2019
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Coping resources and stress reactions among Bedouin Arab adolescents during three military operations.

Psychiatry Res 2019 Jan 30;273:559-566. Epub 2019 Jan 30.

Conflict Management & Resolution Program, Department of Interdisciplinary Studies, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 8410501, Israel.

This study aimed to examine coping resources (sense of coherence and hope) and stress reactions among Bedouin Arab adolescents in southern Israel during three periods of escalated political violence. Two main questions were examined: 1) Did adolescents report different coping resources and levels of stress reactions during these three different periods? 2) Were there any differences in the pattern of the associations between coping resources and stress reactions across those periods? Data were gathered from 81, 91, and 192 Bedouin Arab adolescents, who were 14-18 years old, during three periods. Participants completed self-report questionnaires including the sense of coherence (SOC) scale, a hope index, a measure or state anxiety and state anger, a measure of psychological distress, and a demographic questionnaire. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.088DOI Listing
January 2019
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Celebrating the contributions of Monte and Sherry Buchsbaum and their impact on Psychiatry Research.

Authors:
Lynn E DeLisi

Psychiatry Res 2019 Jan 27. Epub 2019 Jan 27.

VA Boston Healthcare System, Harvard Medical School, Brockton, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2019.01.075DOI Listing
January 2019

Clinical efficacy of trauma-focused psychotherapies in treatment-resistant depression (TRD) in-patients: A randomized, controlled pilot-study.

Psychiatry Res 2019 Jan 24;273:567-574. Epub 2019 Jan 24.

Psychiatric Hospital "Villa Santa Chiara", Verona, Italy.

In major depressive disorder (MDD) patients, life stress events represent a risk factor for a severe, early-onset, treatment-resistant and chronic endophenotype. Treatment-resistant depression (TRD) patients who have experienced traumatic events could benefit from evidence-based trauma-focused psychotherapies. Because this topic has never been investigated, the aim of this pilot trial was to evaluate whether trauma-focused cognitive-behavioural therapy (TF-CBT) and/or eye movement desensitization and reprocessing (EMDR) can help achieve depressive symptom remission in TRD patients. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.070DOI Listing
January 2019
2.467 Impact Factor

Decreased functional brain response to emotional arousal and increased psychiatric symptomology in FMR1 premutation carriers.

Psychiatry Res Neuroimaging 2019 Jan 29;285:9-17. Epub 2019 Jan 29.

Patrick Wild Centre, Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, United Kingdom.

The FMR1 premutation is an expansion of the CGG repeat island in the FMR1 gene to between 55 and 200 repeats. Evidence suggests that as well as conferring risk for neurodegeneration, the premutation is also associated with increased risk for autistic traits and psychiatric symptoms. An emotional processing fMRI task was used to examine the response to a change in emotional arousal in 17 male carriers and 17 matched controls. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.011DOI Listing
January 2019
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Interactive effect of 5-HTTLPR and BDNF polymorphisms on amygdala intrinsic functional connectivity and anxiety.

Psychiatry Res Neuroimaging 2019 Jan 29;285:1-8. Epub 2019 Jan 29.

Department of Psychology, Georgetown University, 306 White-Gravenor, Washington, DC 20057, United States; Children's Research Institute, Children's National Medical Center, Washington, DC, United States. Electronic address:

The serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) gene polymorphisms have been associated with risk for affective disorders and functional variability of the amygdala. We examined whether the two genotypes interactively influence intrinsic functional connectivity (FC) of the amygdala and whether FC mediates the genetic association with anxiety. Eighty genotyped healthy adults underwent resting state fMRI and completed the self-reported State-Trait Anxiety Inventory. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.010DOI Listing
January 2019
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Breakfast consumption and the risk of depressive symptoms: The Furukawa Nutrition and Health Study.

Psychiatry Res 2019 Jan 24;273:551-558. Epub 2019 Jan 24.

Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.

Breakfast consumption has been suggested to influence mood, but prospective evidence on this issue is limited. We prospectively investigated the association between the frequency of breakfast consumption and the risk of depressive symptoms in Japanese employees. Participants were 716 employees aged 19-68 years who were free from depressive symptoms and mental disorders at baseline and who attended the 3-year follow-up survey. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.069DOI Listing
January 2019
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Emotion processing in intermittent explosive disorder.

Psychiatry Res 2019 Jan 14;273:544-550. Epub 2019 Jan 14.

Department of Psychology, Temple University, 1701N. 13th Street, Philadelphia, PA 19122, USA.

Intermittent explosive disorder (IED), a disorder characterized by outbursts of affective aggression, is associated with deficits in regulating emotions. However, less is known about specific deficits in understanding and processing emotions in IED. This study sought to fill that gap by examining components of emotion processing (rumination, alexithymia, and empathy) in those with IED. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.046DOI Listing
January 2019
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The nature of bradykinesia in schizophrenia treated with antipsychotics.

Psychiatry Res 2019 Jan 15;273:537-543. Epub 2019 Jan 15.

University of California, San Diego, CA, United States; VA San Diego, Center of Excellence for Stress and Mental Health.

Recognizing drug-induced parkinsonian bradykinesia in psychosis patients can be challenging due to overlapping presentation with psychomotor slowing associated with depression, negative symptoms, or cognitive disturbances. In this study, we apply prior findings on the pathophysiology of bradykinesia in Parkinson's disease to gain an understanding of motor slowing in psychosis patients. Handwriting movements from 57 healthy participants and 70 psychosis patients were recorded on a digitizing tablet. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183213
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http://dx.doi.org/10.1016/j.psychres.2019.01.058DOI Listing
January 2019
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Brain-derived neurotrophic factor is associated with cognitive impairments in first-episode and chronic schizophrenia.

Psychiatry Res 2019 Jan 18;273:528-536. Epub 2019 Jan 18.

Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Mental Disorders, Changsha, China; National Technology Institute on Mental Disorders, Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China.

Brain-derived neurotrophic factor (BDNF) may be related to the pathophysiology of schizophrenia. This study aims to examine the relation between plasma BDNF levels and the cognition of patients with schizophrenia. We recruited 31 patients with chronic schizophrenia, 34 first-episode patients, and 35 healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.051DOI Listing
January 2019
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The association of smartphone use and depression in Japanese adolescents.

Psychiatry Res 2019 Jan 26;273:523-527. Epub 2019 Jan 26.

Department of Nursing, Nagoya University Graduate School of Medicine, 1-1-20, Daiko-minami, Higashi-ku, Nagoya 461-8673, Japan.

The aim of this study is to assess the association between smartphone usage and depression in each gender of senior high school students. A cross-sectional study with self-administered questionnaires for 295 high school students, aged 15-19 was conducted in Japan. Depression was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.074DOI Listing
January 2019