574,205 results match your criteria Psychiatry 2010[Journal]


[Different care models and symptom progression of Alzheimer's disease in China].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):532-536

Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To compare the differences of cognitive function, daily living ability and neuropsychiatric symptoms in patients with sporadic type of Alzheimer's disease (AD) under different care modes, and find the most favorable care mode for delaying the progress of disease. One hundred and twenty cases of AD patients were divided into three groups: Spouse Care Group, Adult Child Care Group and Nursing Home Group. Medical history collection and scale evaluation were carried out by trained specialists on 3 groups of patients and caregivers. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.011DOI Listing
February 2019

[Correlation among serum levels of Irisin, insulin resistance and abdominal obesityin patients with first-episode schizophrenia].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):520-524

Department of Psychiatry, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.

To explore the possible role of Irisin in antipsychotic drug-induced insulin resistance and abdominal obesity in patients with schizophrenia and to provide a theoretical basis for the prevention of antipsychotic drug-induced obesity. Fifty-five patients with first-episode schizophrenia, from the First Affiliated Hospital of Zhengzhou University, between January 2016 and December 2017, were admitted as well as fifty healthy controls during the same period. Serum Irisin levels were measured by enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.009DOI Listing
February 2019

The prevalence and diagnostic classification of mixed features in patients with major depressive episodes: A multicenter study based on the DSM-5.

Int J Methods Psychiatr Res 2019 Feb 20:e1773. Epub 2019 Feb 20.

Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: The purpose of this study was to evaluate the prevalence of mixed features using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and to examine how patients with mixed states would be classified using the DSM-5.

Methods: In total, 12 hospitals participated in this study, and data on the demographic characteristics and clinical diagnoses of patients treated between October 2013 and September 2016 were obtained. We reviewed the data for opposite-polarity symptoms according to the DSM-5 criteria and the research-based diagnostic criteria. Read More

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http://dx.doi.org/10.1002/mpr.1773DOI Listing
February 2019

Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA.

Neuropsychopharmacology 2019 Feb 20. Epub 2019 Feb 20.

School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia.

Circular RNAs (circRNAs) are a covalently closed subclass of lncRNA molecules formed by back splicing of linear precursor RNA. These molecules are relatively stable and particularly abundant in the mammalian brain and therefore may participate in neural development and function. With the emergence of circRNAs activity in gene regulation, these molecules have been implicated in several biological processes, including synaptic plasticity, and we therefore suspect they may have a role in neurobehavioral disorders. Read More

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http://dx.doi.org/10.1038/s41386-019-0348-1DOI Listing
February 2019

Using A Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, NY 10027, USA; email: , , ,

Children's development is largely dependent on caregiving; when caregiving is disrupted, children are at increased risk for numerous poor outcomes, in particular psychopathology. Therefore, determining how caregivers regulate children's affective neurobiology is essential for understanding psychopathology etiology and prevention. Much of the research on affective functioning uses fear learning to map maturation trajectories, with both rodent and human studies contributing knowledge. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095727DOI Listing
February 2019

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email:

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095754DOI Listing
February 2019

Man and the Microbiome: A New Theory of Everything?

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Departments of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 K8AF, Ireland; email:

The gut microbiome is implicated in the pathophysiology of a wide range of psychological disorders. Preclinical studies have provided us with key insights into the mechanisms by which the microbiome influences bidirectional gut-brain communication. There are many signaling pathways involved, including the hypothalamic-pituitary-adrenal axis, immune modulation, tryptophan and serotonin metabolism, bile acid transformation, microbial production of neuroactive compounds, and regulation of the endocannabinoid system. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095432DOI Listing
February 2019

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Geriatric Research, Education, and Clinical Center, Tennessee Valley Veterans Affairs Medical Center, Nashville, Tennessee 37212, USA.

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095557DOI Listing
February 2019

Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study.

J Clin Psychiatry 2019 Feb 19;80(2). Epub 2019 Feb 19.

Bipolar Disorder Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Objective: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR).

Methods: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the context of bipolar I or II disorder (BD-I, BD-II, respectively) or major depressive disorder, were enrolled between June 2009 and July 2010. Patients with (MDE-AL, n = 694) and without (MDE-noAL, n = 1,883) AL and with (MDE-MR, n = 1,035) or without (MDE-noMR, n = 1,542) MR were compared through χ² test or Student t test. Read More

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http://dx.doi.org/10.4088/JCP.17m12082DOI Listing
February 2019

Enhancing the Treatment of Patients With Schizophrenia Through Continuous Care.

J Clin Psychiatry 2019 Feb 19;80(1). Epub 2019 Feb 19.

University of North Carolina School of Medicine, Carrboro, North Carolina, USA.

Schizophrenia is a chronic disorder that can be effectively controlled but will likely require lifelong treatment. Unfortunately, most patients experience numerous relapses, ongoing symptoms, and impairment, often because of treatment interruptions. Continuous treatment is imperative to prevent relapse and the potentially devastating consequences that can follow a return of psychotic symptoms. Read More

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http://dx.doi.org/10.4088/JCP.al18010ah2cDOI Listing
February 2019

Exploring the behavioral and cognitive phenotype of KBG syndrome.

Genes Brain Behav 2019 Feb 20:e12553. Epub 2019 Feb 20.

Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.

KBG syndrome is a neurodevelopmental disorder, caused by dominant mutations in ANKRD11, that is characterized by developmental delay/intellectual disability, mild craniofacial dysmorphisms, and short stature. Behavior and cognition have hardly been studied, but anecdotal evidence suggests higher frequencies of ADHD-symptoms and social-emotional impairments. In this study, behavioral and cognitive profile of KBG syndrome will be investigated in order to examine if and how cognitive deficits contribute to behavioral difficulties. Read More

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http://dx.doi.org/10.1111/gbb.12553DOI Listing
February 2019

Psychotropic medication use trends in a large pediatric and young adult solid organ transplant population.

Pediatr Transplant 2019 Feb 20:e13380. Epub 2019 Feb 20.

Boston Children's Hospital Department of Psychiatry, Boston, Massachusetts.

Introduction: This study describes psychotropic medication use in a pediatric and young adult solid organ transplant population.

Methods: We conducted a retrospective review of the lifetime incidence of psychotropic medication use and associated characteristics in patients seen over a 6-year period at a large pediatric transplant center utilizing univariate and multivariate statistical analyses.

Results: The lifetime incidence of psychotropic medication use was 36. Read More

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http://dx.doi.org/10.1111/petr.13380DOI Listing
February 2019

Hematopoietic stem cell transplantation in children with sickle cell anemia: The parents' experience.

Pediatr Transplant 2019 Feb 20:e13376. Epub 2019 Feb 20.

Department of Psychopathology, Avicenne Hospital, Paris XIII University & Assistance Publique-Hôpitaux de Paris, Bobigny, France.

Genoidentical HSCT is currently the only curative treatment for SCA, preventing further vascular complications in high-risk children. Studies on the psychological implications of HSCT for recipient, sibling donor, and the rest of the family have been limited in SCA. This study enrolled ten families and used semi-structured interviews to explore the parents' experience at three time points: first before transplantation, then 3 months later, and 1 year later. Read More

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http://dx.doi.org/10.1111/petr.13376DOI Listing
February 2019

Editorial: Can dysregulated myelination be linked to ADHD pathogenesis and persistence?

J Child Psychol Psychiatry 2019 Mar;60(3):229-231

Converging evidence from new epidemiologic, genetic, epigenetic, neuroimaging, and experimental model findings are further refining a long-standing concept, regarding the underlying neurobiology of attention-deficit/hyperactivity disorder (ADHD): that ADHD onset and its persistence into adulthood are the result of dysregulated myelination and associated alterations in neuronal plasticity - linked to disrupted brain maturation and the persistence of cognitive and emotional impairments across the life span. If supported by further work, this concept represents a pathophysiologic mechanism amenable to therapeutic intervention. Read More

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http://dx.doi.org/10.1111/jcpp.13031DOI Listing

Social cognition in bipolar disorder: the role of sociodemographic, clinical and neurocognitive variables in emotional intelligence.

Acta Psychiatr Scand 2019 Feb 20. Epub 2019 Feb 20.

Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Objective: The main aims of this study were to examine the differences in the Emotional Intelligence (EI), the emotional domain of social cognition (SC), between euthymic patients with bipolar disorder (BD) and healthy controls (HC) and to evaluate the contribution of sociodemographic, clinical and neuropsychological variables to EI.

Methods: We recruited 202 patients with BD and 50 HC. EI was evaluated using the Mayer Salovey Caruso Emotional Intelligence Test (MSCEIT). Read More

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http://dx.doi.org/10.1111/acps.13014DOI Listing
February 2019

[Is Big Data the future of Psychiatry?]

Authors:
Javier Fabrissin

Vertex 2018 Sep;XXIX(141):379-387

Sistema Provincial de Salud, Gobierno de Tucumán, Argentina. Cátedra de Salud Mental II, Carrera de Medicina, Universidad de San Pablo, Tucumán, Argentina.

Big Data is a term that describes large volumes of high velocity, complex, and variable data that require advanced techniques and technologies to enable the capture, storage, distribution, management, and analysis of information. Big data analytics are a growing field in healthcare, offering probabilistic answers or statistical correlations to specific phenomena which, in turn, could be used to assist in decision-making at an epidemiological, clinical, diagnostic, or therapeutic level. Psychiatry itself also can take advantage of big data by applying its analytics into early detection of mental disorders, in the definition of therapeutic response criteria, for the classification of mental disorders. Read More

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September 2018

[Lost objects: The territory of study and action of Psychiatry].

Authors:
Marcos Zurita

Vertex 2018 Sep;XXIX(141):374-378

Capítulo de Interconsulta y Psiquiatría de Enlace. Revista Atlas.

The aim of this paper is to discuss about some key issues concerning psychiatry. What really does a psychiatrist nowadays? What kind of disorder does he treat? Why psychiatry keeps itself apart from other specialties and within its own autonomous field? Having in mind the differences between the mental disorders, can we consider that the same semiological elements are appropriate for all of them or do we need to resume an individual analysis from each of those disorders? Can we go through the sparse spectrum of neurotic disorders ignoring the market forces or the dualistic interpretation? In this context, there is still room for questioning: is there an undiscovered explanation regarding the psychiatry disorders or are we trying to find a whole rationale explanation to study non-agroupable objects, lacking of that aforementioned common nuclear logic? And finally, could it be that the constant variables which we assume as the constitutive elements of psychiatric objects are barely the shifting boundaries that change as the time and the culture does? Read More

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September 2018

[Brain and mind: Dissidence or subordination? Notes for an epistemological reading].

Authors:
Juan C Fantin

Vertex 2018 Sep;XXIX(141):368-373

Departamento de Psiquiatría y Salud Mental, Facultad de Medicina (UBA).

Two opposing readings of significant authors - Eric Kandel and Hans Jonas - are examined in relation to the mind-brain problem. From there, the thesis is argued that the inadequacy of the critique of materialistic scientism reduces the theoretical and practical possibilities of both psychiatry and psychoanalysis. Read More

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September 2018

[Notes for a Psychiatry based on narrations].

Vertex 2018 Sep;XXIX(141):361-367

Servicio de Psiquiatría del Hospital Italiano de Buenos Aires.

In this paper some ideas about the possible relationships between literature and psychiatry are presented. To carry out this task, the work "The initial form: conversations in Princeton" by the argentine writer Ricardo Piglia is analyzed, with the aim of installing a reflection on the current moment of the specialty. Read More

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September 2018

[Clinical anthropology: Between the Philosophy of Psychiatry and Human Sciences].

Vertex 2018 Sep;XXIX(141):349-360

Facultad de Psicología, Universidad de Buenos Aires.

The terms "Psycho-logy", "Psycho-patho-logy", "Psychiatry" speaks us, considering Greek etymology, about the Platonic Dualism that distinguishes a rational psyche opposed to a body-jail - tomb of the soul, where a "logic of the separation" will become a "logic of the disjunction", where the "world of ideas" represents the reason while "sensible world" translates the deviation, the madness. Through various oppositions, it shows the need for a globalizing environment that allows joining the social and/or human sciences with the biological sciences. Exactly, the clinical Anthropology constitutes a new disciplinary space that analyzes forms of subjectivation and of the suffering human, in their plurality of dimensions and "directions of sense". Read More

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September 2018

[Philosophy and Psychiatry].

Vertex 2018 Sep;XXIX(141):346-348

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September 2018

[From treatment-resistant epilepsy to psychosis: Literature review and case report].

Vertex 2018 Sep;XXIX(141):325-329

Universidad de Caen, Francia.

The authors present a case in which they describe the challenges posed by the diagnosis of epileptic patients who suffer a psychotic episode. They also give a detailed account of current practice guidelines in French psychiatry, as well as a discussion regarding the art of everyday clinical practice. Read More

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September 2018

[Sustainable development goals and mental health].

Vertex 2018 Nov;XXIX(142):300-303

Centre for Global Mental Health, King's College London, Institute of Psychiatry.

In 2015, the United Nations Sustainable Development Goals (SDGs) set the course for a more equitable distribution of resources globally. For the first time in history, this collective global commitment explicitly included mental health-related objectives, and manifested them as targets in the health SDG 3. This represents a unique opportunity to increase coverage and quality of services, especially in low- and middle-income countries, in which the current treatment gap surpasses 80% even for the most severe disorders. Read More

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November 2018

White noise speech illusions in the general population: The association with psychosis expression and risk factors for psychosis.

PLoS One 2019 20;14(2):e0211914. Epub 2019 Feb 20.

Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Introduction: Positive psychotic experiences are associated with increased rate of white noise speech illusions in patients and their relatives. However, findings have been conflicting to what degree speech illusions are associated with subclinical expression of psychosis in the general population. The aim of this study was to investigate the link between speech illusions and positive psychotic experiences in a general population sample. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211914PLOS
February 2019

Disrupted reinforcement learning during post-error slowing in ADHD.

PLoS One 2019 20;14(2):e0206780. Epub 2019 Feb 20.

The Hospital for Sick Children, Department of Psychiatry, Toronto, Ontario, Canada.

ADHD is associated with altered dopamine regulated reinforcement learning on prediction errors. Despite evidence of categorically altered error processing in ADHD, neuroimaging advances have largely investigated models of normal reinforcement learning in greater detail. Further, although reinforcement leaning critically relies on ventral striatum exerting error magnitude related thresholding influences on substantia nigra (SN) and dorsal striatum, these thresholding influences have never been identified with neuroimaging. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206780PLOS
February 2019

T and B cell subsets differentially correlate with amyloid deposition and neurocognitive function in patients with amnestic mild cognitive impairment after one year of physical activity.

Exerc Immunol Rev 2019 ;25:34-49

Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USA. Dept. of Neurology, University of Kentucky, 741 S. Limestone St, Lexington, KY, 40506, USA.

Individuals with amnestic mild cognitive impairment (aMCI) experience cognitive declines in learning and memory greater than expected for normal aging, and are at a high risk of dementia. We previously reported that sedentary aMCI patients exhibited neuroinflammation that correlated with brain amyloid beta (Aβ) burden, as determined by 18F-florbetapir positron emission tomography (PET). These aMCI patients enrolled in a one-year randomized control trial (AETMCI, NCT01146717) to test the beneficial effects of 12 months of moderate-to-high intensity aerobic exercise training (AET) or stretching/toning (ST) control intervention on neurocognitive function. Read More

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January 2019

Are Impairments in Theory of Mind Specific to Borderline Personality Disorder?

J Pers Disord 2019 Feb 20:1-15. Epub 2019 Feb 20.

Institute for Clinical Medicine, University of Oslo.

Impaired theory of mind (ToM) is an assumed feature of borderline personality disorder (BPD). Yet, no studies have compared ToM abilities in patients with BPD, other personality disorders, and healthy controls, or investigated the relationship between ToM and severity of psychopathology and interpersonal problems. In this study, ToM was investigated by the Movie for the Assessment of Social Cognition. Read More

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http://dx.doi.org/10.1521/pedi_2019_33_417DOI Listing
February 2019

Bridging the Gap Between Remission and Recovery in BPD: Qualitative Versus Quantitative Perspectives.

Authors:
Paul H Soloff

J Pers Disord 2019 Feb 20:1-20. Epub 2019 Feb 20.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

The 10-year outcome for patients with borderline personality disorder (BPD) is diagnostic remission in 85% to 93%; however, less than half achieve good social and vocational functioning, and few attain full psychosocial recovery. To assess the gap between diagnostic remission and psychosocial recovery, quantitative measures of outcome were compared with narrative reports of psychosocial functioning in 150 BPD subjects followed prospectively from 2 to 31 years (mean 9.94 years). Read More

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http://dx.doi.org/10.1521/pedi_2019_33_419DOI Listing
February 2019

Attitudes of Mental Health Staff Toward Patients With Borderline Personality Disorder: An Italian Cross-Sectional Multisite Study.

J Pers Disord 2019 Feb 20:1-16. Epub 2019 Feb 20.

Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Negative attitudes toward borderline personality disorder (BPD) can present a barrier to those seeking care. We explored caring attitudes toward BPD among 860 mental health professionals, including psychiatrists, psychologists, social health educators, nurses, and social workers. The results showed that social workers and nurses scored significantly lower on caring attitudes than psychiatrists, social health educators, and psychologists. Read More

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http://dx.doi.org/10.1521/pedi_2019_33_421DOI Listing
February 2019

An Exploration of Useful Telemedicine-Based Resources for Clinical Research.

Telemed J E Health 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Psychiatry and Behavioral Sciences, Biomedical Informatics Center, College of Medicine, Medical University of South Carolina, Charleston, South Carolina.

Background: Clinical trials are key to ensuring high-quality, effective, and safe health care interventions, but there are many barriers to their successful and timely implementation. Difficulties with participant recruitment and enrollment are largely affected by difficulties with obtaining informed consent. Teleconsent is a telemedicine- based approach to obtaining informed consent and offers a unique solution to limitations of traditional consent approaches. Read More

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http://dx.doi.org/10.1089/tmj.2018.0221DOI Listing
February 2019

Identifying Efficacious Treatment Elements for Refractory Conditions, Such as Body Dysmorphic Disorder.

Authors:
Douglas S Mennin

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Teachers College, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4084DOI Listing
February 2019

Response to Hurricane Maria, Anecdotal Notes on the Coast Guard's Role.

Mil Med 2019 Feb 20. Epub 2019 Feb 20.

Eastern Virginia Medical School, Department of Psychiatry, 825 Fairfax Ave # 710, Norfolk, VA.

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http://dx.doi.org/10.1093/milmed/usz012DOI Listing
February 2019

Efficacy and Posttreatment Effects of Therapist-Delivered Cognitive Behavioral Therapy vs Supportive Psychotherapy for Adults With Body Dysmorphic Disorder: A Randomized Clinical Trial.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

Importance: Cognitive behavioral therapy (CBT), the best-studied treatment for body dysmorphic disorder (BDD), has to date not been compared with therapist-delivered supportive psychotherapy, the most commonly received psychosocial treatment for BDD.

Objective: To determine whether CBT for BDD (CBT-BDD) is superior to supportive psychotherapy in reducing BDD symptom severity and associated BDD-related insight, depressive symptoms, functional impairment, and quality of life, and whether these effects are durable.

Design, Setting, And Participants: This randomized clinical trial conducted at Massachusetts General Hospital and Rhode Island Hospital recruited adults with BDD between October 24, 2011, and July 7, 2016. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4156DOI Listing
February 2019

Response to Letter to the Editor from Dr J. Edwin Nieves of Coast Guard Auxiliary Flotilla 63.

Mil Med 2019 Feb 20. Epub 2019 Feb 20.

Naval Medical Center Portsmouth, Department of Psychiatry, 620 John Paul Jones Circle, Portsmouth, VA.

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http://dx.doi.org/10.1093/milmed/usz013DOI Listing
February 2019

Can Adjunctive Pharmacotherapy Reduce Hospitalization in Schizophrenia?: Insights From Administrative Databases.

Authors:
Donald C Goff

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, New York.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4318DOI Listing
February 2019

Medical Devices to Prevent Opioid Use Disorder: Innovative Approaches to Addressing the Opioid Crisis.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4379DOI Listing
February 2019

Comparative Effectiveness of Adjunctive Psychotropic Medications in Patients With Schizophrenia.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York.

Importance: People with schizophrenia are commonly treated with psychotropic medications in addition to antipsychotics, but there is little evidence about the comparative effectiveness of these adjunctive treatment strategies.

Objective: To study the comparative real-world effectiveness of adjunctive psychotropic treatments for patients with schizophrenia.

Design, Setting, And Participants: This comparative effectiveness study used US national Medicaid data from January 1, 2001, to December 31, 2010, to examine the outcomes of initiating treatment with an antidepressant, a benzodiazepine, a mood stabilizer, or another antipsychotic among adult outpatients (aged 18-64 years) diagnosed with schizophrenia who were stably treated with a single antipsychotic. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4489DOI Listing
February 2019

Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Importance: The effectiveness of antipsychotic polypharmacy in schizophrenia relapse prevention is controversial, and use of multiple agents is generally believed to impair physical well-being.

Objective: To study the association of specific antipsychotic combinations with psychiatric rehospitalization.

Design, Setting, And Participants: In this nationwide cohort study, the risk of psychiatric rehospitalization was used as a marker for relapse among 62 250 patients with schizophrenia during the use of 29 different antipsychotic monotherapy and polypharmacy types between January 1, 1996, and December 31, 2015, in a comprehensive, nationwide cohort in Finland. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4320DOI Listing
February 2019

The latent structure of the Young Schema Questionnaire-Short Form.

Braz J Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Departamento de Psicologia, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil.

Objective: The current study aimed to examine the latent structure of a web-based, Brazilian Portuguese version of the Young Schema Questionnaire-Short Form (YSQ-SF).

Method: The sample consisted of 15,557 adult participants - 4,702 men and 10,855 women - with age ranging from 18 to 60 years. Confirmatory factor analysis was used to test the a priori conceptual 15-factor model presumed to underlie the YSQ-SF item set. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0261DOI Listing
February 2019

Psychological morbidity is the main predictor of quality of life among caregivers of individuals in first-episode psychosis: data from a year-long longitudinal study in Brazil.

Braz J Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Programa de Assistência e Pesquisa ao Primeiro Episódio Psicótico (PEP), Departamento de Psiquiatria, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Objective: To investigate quality of life (QoL) and QoL predictors among caregivers of individuals in first-episode psychosis (FEP).

Methods: This longitudinal study investigated predictors of QoL in caregivers of 80 individuals in FEP over a 1-year follow-up period, measured using a single component extracted from the 36-item Short-Form Health Survey (SF-36).

Results: Mediation analysis demonstrated that, at 1 year, high scores in the Self-Report Questionnaire (SRQ-20) were associated with high scores on the negative sub-scale of the Experience of Caregiving Inventory (ECI), which was also associated with low scores in the Essential Quality of Life (Essential QoL) component extracted from the SEF-36. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0169DOI Listing
February 2019

Development and psychometric evaluation of the Mandarin Chinese version of the Yale-Brown Obsessive-Compulsive Scale - Second Edition.

Braz J Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.

Objective: To examine the psychometric properties of the Chinese version of the Yale-Brown Obsessive Compulsive Scale - Second Edition (Y-BOCS-II).

Method: A total of 86 adults with a primary diagnosis of obsessive-compulsive disorder (OCD), ranging in age from 15 to 78 years, participated in the study. Participants were administered the Y-BOCS-II by a trained clinician who also rated overall illness severity on two additional measures. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0126DOI Listing
February 2019

SIGMA-VB: Validity and reliability of the Brazilian Portuguese version of the Montgomery-Åsberg Depression Rating Scale using the Structured Interview Guide for the MADRS.

Braz J Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Grupo de Estudos de Doenças Afetivas (GRUDA), Departamento de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Objective: The Montgomery-Åsberg Depression Rating Scale (MADRS) is widely used to assess depression severity. The Structured Interview Guide for the MADRS (SIGMA) was created to standardize MADRS assessment. The objective of this study was to translate and validate the original SIGMA into a Brazilian Portuguese version (SIGMA-VB). Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0105DOI Listing
February 2019
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