735,468 results match your criteria Psychiatric services Washington D.C.[Journal]


Can continual interictal epileptiform discharges cause persistent memory disturbances?

Psychogeriatrics 2019 Feb 18. Epub 2019 Feb 18.

Department of Psychiatry, Shinjuku Shinkei Clinic, Tokyo, Japan.

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http://dx.doi.org/10.1111/psyg.12429DOI Listing
February 2019

Segregation of salience network predicts treatment response of depression to repetitive transcranial magnetic stimulation.

Neuroimage Clin 2019 Feb 13;22:101719. Epub 2019 Feb 13.

Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Background: The present study tested the hypothesis that network segregation, a graph theoretic measure of functional organization of the brain, is correlated with treatment response in patients with major depressive disorder (MDD) undergoing repetitive transcranial magnetic stimulation (rTMS).

Methods: Network segregation, calculated from resting state functional magnetic resonance imaging scans, was measured in 32 patients with MDD who entered a sham-controlled, double-blinded, randomized trial of rTMS to the left dorsolateral prefrontal cortex, and a cohort of 20 healthy controls (HCs). Half of the MDD patients received sham treatment in the blinded phase, followed by active rTMS in the open-label phase. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101719DOI Listing
February 2019

County-level socioeconomic and crime risk factors for substantiated child abuse and neglect.

Child Abuse Negl 2019 Feb 15;90:127-138. Epub 2019 Feb 15.

Department of Psychology and Human Development, Vanderbilt University, United States.

Rates of substantiated child abuse and neglect vary significantly across counties. Despite strong cross-sectional support for links between social-contextual characteristics and abuse and neglect, few longitudinal studies have tested relations between these risk factors and substantiated rates of abuse/neglect. The goal of this study was to identify county-level socioeconomic and crime factors associated with substantiated abuse/neglect rates over 13 years (2004-2016). Read More

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http://dx.doi.org/10.1016/j.chiabu.2019.02.004DOI Listing
February 2019

Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.

Cortex 2019 Jan 29;115:99-111. Epub 2019 Jan 29.

Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Parkinson's disease (PD) is characterized by dysfunction in frontal cortical and striatal networks that regulate action control. We investigated the pharmacological effect of dopamine agonist replacement therapy on frontal cortical activity and motor inhibition. Using Arterial Spin Labeling MRI, we examined 26 PD patients in the off- and on-dopamine agonist medication states to assess the effect of dopamine agonists on frontal cortical regional cerebral blood flow. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.01.016DOI Listing
January 2019

Non-pharmacological therapies for depressive symptoms in breast cancer patients: Systematic review and meta-analysis of randomized clinical trials.

Breast 2019 Jan 31;44:135-143. Epub 2019 Jan 31.

DPH, Instituto Nacional de Salud Pública, Av. Universidad 655, Sta. Ma. Ahuacatitlán, C.P. 62100, Cuernavaca, Morelos, Mexico. Electronic address:

Objective: Depressive symptoms are common comorbidities among breast cancer (BC) patients. Non-pharmacological therapies (NPTs) such as exercise and psychotherapy may reduce depressive symptoms; however, the evidence is inconclusive. The objective of this study is to evaluate if NPTs reduce depressive symptoms among BC patients. Read More

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http://dx.doi.org/10.1016/j.breast.2019.01.006DOI Listing
January 2019

Spastic dystonia in stroke subjects: prevalence and features of the neglected phenomenon of the upper motor neuron syndrome.

Clin Neurophysiol 2019 Feb 6;130(4):521-527. Epub 2019 Feb 6.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Italy; Department of Neuroscience, IRCCS Ospedale Policlinico San Martino, Genova, Italy. Electronic address:

Objective: Spastic dystonia is one of the positive phenomena of the upper motor neuron syndrome (UMNS). It is characterised by the inability to relax a muscle leading to a spontaneous, although stretch-sensitive, tonic contraction. Although spastic dystonia is a recognized cause of muscle hypertonia, its prevalence among hypertonic muscles of stroke subjects has never been investigated. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.012DOI Listing
February 2019

The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 Feb 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
February 2019

Autistic traits impact on olfactory processing in adolescent girls with Anorexia Nervosa restricting type.

Psychiatry Res 2019 Feb 11;274:20-26. Epub 2019 Feb 11.

IRCCS Fondazione Stella Maris, Pisa, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

The correct functioning of the chemosensory pathway is pivotal for the attitude towards feeding. In some neuropsychiatric disorders, abnormalities of the sensory processing dramatically affect feeding behavior; however, evidences for an olfactory involvement in Anorexia Nervosa (AN) are still controversial. We administered a complete olfactory testing battery, the Sniffin' Sticks Extended Test, to a cohort of 19 girls with Restrictive Anorexia Nervosa (AN-R) and 19 healthy controls. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.026DOI Listing
February 2019

Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls.

J Psychiatr Res 2019 Feb 8;111:169-185. Epub 2019 Feb 8.

Brain Research Center, Ankara University, Ankara, Turkey. Electronic address:

Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.022DOI Listing
February 2019

Trends in concept and nosology of autism spectrum disorder: A review.

Asian J Psychiatr 2019 Feb 10;40:92-99. Epub 2019 Feb 10.

Department of Psychiatry and National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.

Autism Spectrum Disorder is a neurodevelopmental disorder characterized by persistent deficits in social communication, social interaction and restricted, repetitive patterns of behavior, interests or activities. The concept of autism has changed since its inception, from childhood schizophrenia to neuro-variation. These changes in concept have been accompanied by changes in the diagnostic threshold through which the 'case' of autism is identified. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.01.021DOI Listing
February 2019

Antipsychotic-minocycline-acetylcysteine combination for positive, cognitive, and negative symptoms of schizophrenia.

Asian J Psychiatr 2019 Feb 12;40:100-102. Epub 2019 Feb 12.

Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, 2300 I St NW, 20037, Washington, DC, USA. Electronic address:

Preclinical evidence shows that the minocycline and N-acetylcysteine (NAC) combination synergistically improved cognition. Meta-analyses of randomized controlled trials (RCTs) with minocycline and NAC have shown some efficacy signal for positive, cognitive, and negative symptoms of schizophrenia. Hence, the combination may be more effective than either medication alone. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.007DOI Listing
February 2019

Mental Pain Questionnaire: An item response theory analysis.

J Affect Disord 2019 Feb 11;249:226-233. Epub 2019 Feb 11.

Department of Health Sciences, University of Florence, Italy; Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, the Netherlands. Electronic address:

Background: The Mental Pain Questionnaire (MPQ) is a self-report questionnaire developed to assess mental pain. The aim of the present study was to test the clinimetric properties of the MPQ.

Methods: A sample of 200 migraine outpatients were enrolled; homogeneity of MPQ was assessed by Mokken Analysis; item-level severity and item-level sensitivity were calculated via Two-Parameter Logistic model; Total Information Function was evaluated to assess reliability of MPQ; internal consistency was calculated via Cronbach's alpha and Sijtsma and Molenaar rho; sensitivity and specificity were assessed via Receiver Operating Characteristic curves. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.030DOI Listing
February 2019

Factors associated with health-related quality of life (HRQOL) in students who survived the Sewol ferry disaster in South Korea.

J Affect Disord 2019 Feb 11;249:223-225. Epub 2019 Feb 11.

Department of Psychiatry, National Medical Center, Seoul, Republic of Korea. Electronic address:

Background: The purpose of this study was to analyze the mental health status of Danwon students who survived the Sewol ferry disaster. The study also evaluated the mental health effects of the disaster on the survivors.

Methods: Questionnaires were used to collect data from selected respondents. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.035DOI Listing
February 2019

A meta-analysis and systematic review of Memory Specificity Training (MeST) in the treatment of emotional disorders.

Behav Res Ther 2019 Feb 2;116:36-51. Epub 2019 Feb 2.

Centre for Learning Psychology and Experimental Psychopathology, University of Leuven, Leuven, Belgium.

The tendency to recall events from one's past in a non-specific and overgeneral way has been found to predict the onset and severity of a range of emotional disorders. Memory Specificity Training (MeST) was devised a decade ago in order to target and modify this tendency so as to reduce the symptoms of emotional disorder or to reduce the risk that such disorders might emerge over time. We present a meta-analytical review of research into the effects of MeST on autobiographical memory specificity in the context of emotional disorders (k = 13). Read More

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http://dx.doi.org/10.1016/j.brat.2019.02.001DOI Listing
February 2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

Neurobiol Aging 2019 Jan 26;77:37-43. Epub 2019 Jan 26.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands. Electronic address:

There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast administration (100, 250, 1000 μg) in a double-blind, placebo-controlled, 4-way crossover design. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.014DOI Listing
January 2019

Evaluating the utility of the modified cigarette evaluation questionnaire and cigarette purchase task for predicting acute relative reinforcing efficacy of cigarettes varying in nicotine content.

Drug Alcohol Depend 2019 Feb 13;197:56-64. Epub 2019 Feb 13.

Departments of Psychiatry and Psychological Science, Vermont Center on Behavior and Health, University of Vermont, Burlington, VT, USA.

Background: Nicotine is the addictive component in cigarettes that maintain cigarette smoking that subsequently leads to morbidity and mortality. Methods for assessing the abuse liability of cigarettes are essential to inform new tobacco product standards. This secondary analysis evaluated the utility of one subjective effects measure, the modified Cigarette Evaluation Questionnaire (mCEQ), and one behavioral economic task, the Cigarette Purchase Task (CPT), for predicting acute relative reinforcing efficacy measured by concurrent choice Self-Administration (SA). Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.004DOI Listing
February 2019

Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women.

Brain Behav Immun 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan; Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan.

Background: Omega-3 polyunsaturated fatty acids (PUFAs) reduce depressive symptoms through an anti-inflammatory effect, and injection of both omega-3 PUFAs and estradiol (E2) induces antidepressant-like effects in rats by regulating the expression of inflammatory cytokines. The aims of this study were to examine the association of increased E2 during pregnancy with depressive symptoms and with inflammatory cytokines in women who were and were not supplemented with omega-3 PUFAs.

Methods: Pregnant women with Edinburgh Postnatal Depression Scale scores ≥ 9 were recruited at 12-24 weeks of gestation. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.014DOI Listing
February 2019

Refractory diet-dependent changes in neural microstructure: Implications for microstructural endophenotypes of neurologic and psychiatric disease.

Magn Reson Imaging 2019 Feb 15. Epub 2019 Feb 15.

Department of Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Neuroscience Training Program, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA. Electronic address:

Alterations in gut microbiome populations via dietary manipulation have been shown to induce diet-dependent changes in white matter microstructure. The purpose of this study is to examine the durability of these diet-induced microstructural alterations. We implemented a crossover experimental design where post-weaned male rats were assigned to one of four experimental diets. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.006DOI Listing
February 2019

TELOMERE LENGTH AND HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES OF OBSERVATIONAL STUDIES.

Ageing Res Rev 2019 Feb 15. Epub 2019 Feb 15.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy; Ambulatory of Nutrition, IRCCS "S. de Bellis" National Institute of Gastroenterology-Research Hospital Castellana Grotte Bari Italy, Italy. Electronic address:

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.003DOI Listing
February 2019
4.940 Impact Factor

Recruitment of central angiotensin II type 1 receptor associated neurocircuits in carbon dioxide associated fear.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

Dept. of Pharmacology and Systems Physiology, University of Cincinnati, United States; Neuroscience Graduate Program, University of Cincinnati, United States; VA Medical Center, Cincinnati, OH, 45221, United States. Electronic address:

Individuals with fear-associated conditions such as panic disorder (PD) and posttraumatic stress disorder (PTSD) display increased emotional responses to interoceptive triggers, such as CO inhalation, that signal a threat to physiological homeostasis. Currently, effector systems and mechanisms underlying homeostatic modulation of fear memory are not well understood. In this regard, the renin angiotensin system (RAS), particularly the angiotensin receptor type 1 (AT1R), a primary homeostatic regulatory target, has gained attention. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.02.007DOI Listing
February 2019

Cognitive Behavioral Therapy for Acute Post-trauma Distress: A Randomized, Controlled, Proof-of-Concept Study among Hospitalized Adults with Burns.

Arch Phys Med Rehabil 2019 Feb 15. Epub 2019 Feb 15.

Johns Hopkins Burn Center, Johns Hopkins Bayview Medical Center, Baltimore, MD; Department of Surgery, Division of Plastics and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Objective: (1) To evaluate the feasibility of conducting a randomized controlled trial (RCT) of the Safety, Meaning, Activation and Resilience Training (SMART) intervention versus Non-Directive Supportive Psychotherapy (NDSP) in an acutely hospitalized adult burn survivor sample; (2) To assess the preliminary impact of SMART on Acute Stress Disorder (ASD)/Posttraumatic Stress Disorder (PTSD) and Major Depress Disorder (MDD) symptom reduction as secondary prevention.

Design: Proof-of-concept, parallel group, RCT design.

Setting: Regional burn center. Read More

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http://dx.doi.org/10.1016/j.apmr.2018.11.027DOI Listing
February 2019

The contributions of socioeconomic status, perceived stress, and depression to disability in adults with systemic lupus erythematosus.

Disabil Rehabil 2019 Feb 18:1-6. Epub 2019 Feb 18.

b Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine , University of California Los Angeles , Los Angeles , CA , USA.

Purpose: Psychological and sociodemographic factors contribute to disability in systemic lupus erythematosus. Yet the pathways by which these factors influence disability remain unclear. The objective of this study was to evaluate a model examining socioeconomic status (SES), perceived stress, and depressive symptoms as determinants of lupus-related disability. Read More

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http://dx.doi.org/10.1080/09638288.2018.1522550DOI Listing
February 2019

[Transition of adolescents with attention deficit/hyperactivity disorder. Implications for treatment of adults].

Medicina (B Aires) 2019 ;79 Suppl 1:72-76

Centro de Salud de Catarroja, Valencia, España.

Attention deficit hyperactivity disorder (ADHD) is a chronic, complex and multifactorial neurodevelopmental disorder associated with high rates of concurrent psychiatric disorders, along with problems and complications on different areas of individual functioning. ADHD is not exclusively a childhood disorder, 40-60% persisting into adulthood with an estimated prevalence of 2.5-5%. Read More

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January 2019

Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease.

J Neuroendocrinol 2019 Feb 18:e12699. Epub 2019 Feb 18.

Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

Huntington's disease (HD) is a heritable neurodegenerative disorder, characterized by metabolic disturbances, along with cognitive and psychiatric impairments. Targeting metabolic HD dysfunction through maintenance of body weight and fat mass and restoration of peripheral energy metabolism can improve the progression of neurological symptoms. In this respect, we focused on the therapeutic potential of the orexigenic peptide hormone ghrelin, which plays an important role in promoting a positive energy balance. Read More

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http://dx.doi.org/10.1111/jne.12699DOI Listing
February 2019

Age-specific Associations between Estradiol, Cortico-Amygdalar Structural Covariance, Verbal and Spatial Skills.

J Neuroendocrinol 2019 Feb 18:e12698. Epub 2019 Feb 18.

Brain Development Cooperative Group.

Estradiol is known to play an important role in the developing human brain, but little is known on the entire network of potential regions which might be affected and on how these effects may vary from childhood to early adulthood, which in turn can explain sexually differentiated behaviors. Here we examined the relationship between estradiol, cortico-amygdalar structural covariance, and cognitive or behavioral measures typically showing sex differences (verbal/spatial skills, anxious-depressed symptomatology) in 152 children and adolescents (6-22 years old). Cortico-amygdalar structural covariance shifted from positive to negative across the age range. Read More

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http://dx.doi.org/10.1111/jne.12698DOI Listing
February 2019

Regulating consumer use of transcranial direct current stimulation devices.

Med J Aust 2018 Jul;209(1):8-9

Monash Alfred Psychiatry Research Centre, Alfred Health, Melbourne, VIC.

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http://dx.doi.org/10.5694/mja17.00778DOI Listing

Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders: A Pseudo-continuous Arterial Spin Labeling Twin Study.

Schizophr Bull 2019 Feb 18. Epub 2019 Feb 18.

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark.

Whether aberrant cerebral blood flow (CBF) in schizophrenia is affected by genetic influences, and consequently a potential marker for genetic susceptibility, is unknown. Our aims were to determine the heritability of CBF in thalamic, frontal, and striatal areas, and to ascertain if associations with disease were under genetic influence. Monozygotic (MZ) twin pairs concordant (n = 2) or discordant (n = 20) for schizophrenia spectrum disorders (ICD-10 F2x. Read More

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http://dx.doi.org/10.1093/schbul/sbz007DOI Listing
February 2019

Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions.

J Alzheimers Dis 2019 ;67(3):923-930

War Related Illness and Injury Study Center, VA Palo Alto Health Care System and Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.

In this issue, an article by La et al. provides evidence that trazodone delayed cognitive decline in 25 participants with Alzheimer's disease (AD), mild cognitive impairment, or normal cognition. For participants considered to have AD pathology, trazodone non-users declined at a rate 2. Read More

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http://dx.doi.org/10.3233/JAD-181106DOI Listing
January 2019

The MemTrax Test Compared to the Montreal Cognitive Assessment Estimation of Mild Cognitive Impairment.

J Alzheimers Dis 2019 ;67(3):1045-1054

War Related Illness and Injury Study Center, VA Palo Alto HCS, Palo Alto, CA, USA.

Cognitive impairment is a leading cause of dysfunction in the elderly. When mild cognitive impairment (MCI) occurs in elderly, it is frequently a prodromal condition to dementia. The Montreal Cognitive Assessment (MoCA) is a commonly used tool to screen for MCI. Read More

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http://dx.doi.org/10.3233/JAD-181003DOI Listing
January 2019

Clinical Presentation, Diagnostic Features, and Mortality in Dementia with Lewy Bodies.

J Alzheimers Dis 2019 ;67(3):995-1005

Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Background: Dementia with Lewy bodies (DLB) is the second most common degenerative dementia in older people. However, rates of misdiagnosis are high, and little is known of its natural history and outcomes. Very few previous studies have been able to access routine clinical information for large, unbiased DLB cohorts in order to establish initial presentation, neuropsychological profile, and mortality. Read More

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http://dx.doi.org/10.3233/JAD-180877DOI Listing
January 2019

Factors Associated with Length of Stay in Hospital Patients with and Without Dementia.

J Alzheimers Dis 2019 ;67(3):1055-1065

Network Aging Research, University of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany.

Background: Hospital care of older adults, especially of those with dementia, is associated with a high risk of complications and increased mortality. Adverse events are often triggered by hospital-related factors, hence the time spent in hospitals should be limited. There is little knowledge of the specific factors influencing hospitalizations of older persons. Read More

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http://dx.doi.org/10.3233/JAD-180593DOI Listing
January 2019

Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health (DINOGMI), University of Genoa, Italy.

Background: Several automatic tools have been implemented for semi-quantitative assessment of brain [18]F-FDG-PET.

Objective: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e. Read More

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http://dx.doi.org/10.3233/JAD-181022DOI Listing
February 2019

Antiepileptic Drug Use Is Associated with an Increased Risk of Pneumonia Among Community-Dwelling Persons with Alzheimer's Disease-Matched Cohort Study.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Background: Antiepileptic drugs (AEDs) have sedative properties which may lead to an increased risk of pneumonia.

Objectives: To investigate whether incident AED use is associated with an increased risk of pneumonia among community-dwelling persons with Alzheimer's disease (AD). In addition, we determined the risk according to duration of AED use and specific AEDs. Read More

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http://dx.doi.org/10.3233/JAD-180912DOI Listing
February 2019

Distinctive Neurochemistry in Alzheimer's Disease via 7 T In Vivo Magnetic Resonance Spectroscopy.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

This study's objective was to increase understanding of biological mechanisms underlying clinical Alzheimer's disease (AD) by noninvasively measuring an expanded neurochemical profile and exploring how well this advanced technology distinguishes AD from cognitively normal controls. We measured concentrations of 14 neurochemicals using ultra-high field (7 T) ultra-short echo time (8 ms) magnetic resonance spectroscopy (MRS) in 16 participants with mild to moderate clinical AD and 33 age- and gender-matched control participants. MRS was localized to the posterior cingulate cortex (PCC), a region known to be impacted by AD, and the occipital cortex (OCC), a control region. Read More

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http://dx.doi.org/10.3233/JAD-180861DOI Listing
February 2019

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Read More

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http://dx.doi.org/10.3233/JAD-180785DOI Listing
February 2019

Serum Potassium Is Associated with Cognitive Decline in Patients with Lewy Body Dementia.

J Alzheimers Dis 2019 Feb 9. Epub 2019 Feb 9.

Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.

Background: Epidemiological studies link serum potassium (K +) to cognitive performance, but whether cognitive prognosis in dementia is related to K + levels is unknown.

Objective: To determine if K + levels predict cognitive prognosis in dementia and if this varies according to diagnosis or neuropathological findings.

Methods: This longitudinal cohort study recruited 183 patients with mild Alzheimer's disease or Lewy body dementia (LBD). Read More

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http://dx.doi.org/10.3233/JAD-181131DOI Listing
February 2019

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.

Elife 2019 Feb 18;8. Epub 2019 Feb 18.

Institute of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany.

Perturbations in mitochondrial function and homeostasis are pervasive in lysosomal storage diseases, but the underlying mechanisms remain unknown. Here, we report a transcriptional program that represses mitochondrial biogenesis and function in lysosomal storage diseases Niemann-Pick type C (NPC) and acid sphingomyelinase deficiency (ASM), in patient cells and mouse tissues. This mechanism is mediated by the transcription factors KLF2 and ETV1, which are both induced in NPC and ASM patient cells. Read More

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http://dx.doi.org/10.7554/eLife.39598DOI Listing
February 2019

A Driving-Force Predictor for Estimating Pathway Activation in Patient-Specific Models of Deep Brain Stimulation.

Neuromodulation 2019 Feb 18. Epub 2019 Feb 18.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Objective: Detailed biophysical modeling of deep brain stimulation (DBS) provides a theoretical approach to quantify the cellular response to the applied electric field. However, the most accurate models for performing such analyses, patient-specific field-cable (FC) pathway-activation models (PAMs), are so technically demanding to implement that their use in clinical research is greatly limited. Predictive algorithms can simplify PAM calculations, but they generally fail to reproduce the output of FC models when evaluated over a wide range of clinically relevant stimulation parameters. Read More

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http://dx.doi.org/10.1111/ner.12929DOI Listing
February 2019

Bone mineral density from early to middle adulthood in persons with Down syndrome.

J Intellect Disabil Res 2019 Feb 18. Epub 2019 Feb 18.

Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.

Background: While accelerated ageing is recognised among individuals with Down syndrome (DS), the trajectory of their bone health across adulthood remains poorly understood.

Methods: This study aimed to determine the age-related loss of bone mineral density (BMD) of the lumbar spine in 128 adults with DS aged 18 to 54 years compared with 723 counterparts without DS.

Results: Men and women with DS had lower level of BMD than counterparts without DS across age groups. Read More

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http://dx.doi.org/10.1111/jir.12608DOI Listing
February 2019

Development of inhibitory control during childhood and its relations to early temperament and later social anxiety: unique insights provided by latent growth modeling and signal detection theory.

J Child Psychol Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.

Background: Children with the temperament of behavioral inhibition (BI) face increased risk for social anxiety. However, not all children with BI develop anxiety symptoms. Inhibitory control (IC) has been suggested as a moderator of the pathway between BI and social anxiety. Read More

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http://dx.doi.org/10.1111/jcpp.13025DOI Listing
February 2019

Practitioner Review: Unguided and guided self-help interventions for common mental health disorders in children and adolescents: a systematic review and meta-analysis.

J Child Psychol Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

UCL Great Ormond Street Institute of Child Health, London, UK.

Mental health problems are common in children and adolescents, yet evidence-based treatments are hard to access. Self-help interventions can increase such access. The aim of this paper was to conduct a systematic review and meta-analysis of the use of guided and unguided self-help for children and young people with symptoms of common mental health disorders. Read More

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http://dx.doi.org/10.1111/jcpp.13010DOI Listing
February 2019

Clinical ethics consultations in psychiatric compared to non-psychiatric medical settings: characteristics and outcomes.

Heliyon 2019 Jan 31;5(1):e01192. Epub 2019 Jan 31.

Department of Clinical Ethics, Evangelisches Klinikum Bethel, Kantensiek 19, 33617 Bielefeld, Germany.

Background: In the recent years clinical ethics consultations (CEC) received an increasing attention not only in patients with medical conditions but also in those with mental disorders. However, the systematic and empirical knowledge is still small. The aim of this observational study was to investigate whether CECs differ between psychiatric and medical hospital inpatients regarding ethical issues, goals, characteristics, processes, and outcomes. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360452PMC
January 2019

The Link between Thyroid Autoimmunity, Depression and Bipolar Disorder.

Open Med (Wars) 2019 16;14:52-58. Epub 2019 Jan 16.

Department of Obstetrics and Gynaecology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Depression and bipolar disorder are two major psychiatric illnesses whose pathophysiology remains elusive. Newly emerging data support the hypothesis that the dysfunction of the immune system might be a potential factor contributing to the development of these mental disorders. The most common organ affected by autoimmunity is the thyroid; therefore, the link between autoimmune thyroid disorders and mental illnesses has been studied since the 1930s. Read More

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http://dx.doi.org/10.1515/med-2019-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371203PMC
January 2019

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice.

Sci Adv 2019 Feb 6;5(2):eaau8317. Epub 2019 Feb 6.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Read More

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http://dx.doi.org/10.1126/sciadv.aau8317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365110PMC
February 2019

A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease.

Sci Adv 2019 Feb 6;5(2):eaau7220. Epub 2019 Feb 6.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London, UK.

A blood-based assessment of preclinical disease would have huge potential in the enrichment of participants for Alzheimer's disease (AD) therapeutic trials. In this study, cognitively unimpaired individuals from the AIBL and KARVIAH cohorts were defined as Aβ negative or Aβ positive by positron emission tomography. Nontargeted proteomic analysis that incorporated peptide fractionation and high-resolution mass spectrometry quantified relative protein abundances in plasma samples from all participants. Read More

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http://dx.doi.org/10.1126/sciadv.aau7220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365111PMC
February 2019

Visual Attention Patterns Differ by Pictorial Health Warning Label Features.

Tob Regul Sci 2018 Nov;4(6):8-17

Department of Psychiatry, University of Pennsylvania Tobacco Center of Regulatory Science and CIRNA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objectives: In this study, we sought to determine how smokers allocate their attention when viewing the 9 cigarette pictorial warning labels (PWLs) proposed by the Food and Drug Administration (FDA), and identify PWL attributes associated with increased attention.

Methods: Using eye-tracking data from an exploratory within-subject study, we examined smokers' attention (latency, latency duration, and dwell time) to areas of interest (image vs textual warning) for each PWL among 95 daily, non-treatment-seeking smokers (62.1% male, 48. Read More

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http://dx.doi.org/10.18001/TRS.4.6.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374036PMC
November 2018
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