6,904 results match your criteria Psychiatric Disorders Associated With Epilepsy


The temporal association of hyperhidrosis and its co-morbidities - a nationwide hospital-based cohort study.

J Eur Acad Dermatol Venereol 2022 Jun 23. Epub 2022 Jun 23.

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.

Background: Research on hyperhidrosis comorbidities has documented the co-occurrence of diseases but has not provided information about temporal disease associations.

Objective: To investigate the temporal disease trajectories of individuals with hospital diagnosed hyperhidrosis.

Methods: This is a hospital-based nationwide cohort study including all patients with a hospital contact in Denmark between 1994 and 2018. Read More

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Minimum spanning tree analysis of brain networks: A systematic review of network size effects, sensitivity for neuropsychiatric pathology, and disorder specificity.

Netw Neurosci 2022 Jun 1;6(2):301-319. Epub 2022 Jun 1.

University Medical Center Utrecht, Department of Psychiatry, Brain Center, Utrecht, the Netherlands.

Brain network characteristics' potential to serve as a neurological and psychiatric pathology biomarker has been hampered by the so-called thresholding problem. The minimum spanning tree (MST) is increasingly applied to overcome this problem. It is yet unknown whether this approach leads to more consistent findings across studies and converging outcomes of either disease-specific biomarkers or transdiagnostic effects. Read More

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Bidirectional influences between seizures and dementia: A systematic review and meta-analysis.

Int J Geriatr Psychiatry 2022 Jul;37(7)

Shanghai Garrison Hongkou Third Retired Cadres Rest House, Shanghai, China.

Objectives: Dementia and seizures often co-exist, but the association between these two disorders is not well established. Therefore, this systematic review and meta-analysis aimed to clarify the relationship between seizures and dementia.

Methods: The PubMed, EMBASE, CBM, and CNKI databases were used to search for relevant publications from inception to August 25, 2021. Read More

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Neuroprotective effect of Geijigadaehwang-tang against trimethyltin-induced hippocampal neurodegeneration: An in vitro and in vivo study.

J Ethnopharmacol 2022 Jun 17:115451. Epub 2022 Jun 17.

Department of Oriental Medicine, College of Oriental Medicine, Dongshin University, 120-9, Dongsindae-gil, Naju-si, Jeollanam-do, 58245, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Patients with dementia are diagnosed with deficiency patterns and interior patterns in traditional Chinese medicine due to decreased physical strength, mental atrophy including cognitive function, and decreased motor function in the gastrointestinal tract. Since "greater yin symptom" in Shanghanlun has been interpreted as interior, deficiency, and cold pattern in traditional Chinese medicine, it is necessary to determine whether Geijigadaehwang-tang (GDT) has therapeutic effects on neurodegenerative diseases and the underlying mechanism if it has such effects.

Aims Of The Study: Trimethyltin (TMT), a neurotoxic organotin compound, has been used to induce several neurodegenerative diseases, including epilepsy and Alzheimer's disease. Read More

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Analysis of mortality metrics associated with a comprehensive range of disorders in Denmark, 2000 to 2018: A population-based cohort study.

PLoS Med 2022 Jun 16;19(6):e1004023. Epub 2022 Jun 16.

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.

Background: The provision of different types of mortality metrics (e.g., mortality rate ratios [MRRs] and life expectancy) allows the research community to access a more informative set of health metrics. Read More

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Role of autoantibodies and blood-brain barrier leakage in cognitive impairment in systemic lupus erythematosus.

Lupus Sci Med 2022 06;9(1)

Department of Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.

Objective: Cognitive impairment is common in patients with SLE but the cause is unknown. The current cross-sectional study examined the association between select SLE-related autoantibodies, other serological biomarkers and extensive blood-brain barrier (BBB) leakage in patients with SLE with and without cognitive impairment. In addition, we determined whether the relationship between SLE autoantibodies, other biomarkers and cognitive impairment differed depending on the presence or absence of concurrent extensive BBB leakage. Read More

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Myoclonic Astatic Resistant Epilepsy and Disproportionate Overgrowth Carrying a Duplication in 2q13 and Deletion in the 6p21.32 Chromosomal Regions.

J Coll Physicians Surg Pak 2022 Jun;32(6):808-810

Department of Dermatology, Duzce University Medical Faculty, Duzce, Turkey.

Copy number variants have been increasing due to a rise in the availability of array comparative genomic hybridisation, which occupies an important place in diagnosis, especially in patients with epilepsy, dysmorphic findings, and intellectual disability. We detected 2q13 chromosomal duplication and 6p21.32 chromosomal deletion in a patient under follow-up due to epilepsy, developmental retardation, dysmorphic findings, and asymmetric overgrowth in our clinic since the age of six months. Read More

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Health Needs and Their Relationship with Life Expectancy in People with and without Intellectual Disabilities in England.

Int J Environ Res Public Health 2022 May 28;19(11). Epub 2022 May 28.

Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.

Health needs are common in people living with intellectual disabilities, but we do not know how they contribute to life expectancy. We used the Clinical Practice Research Datalink (CPRD) linked with hospital/mortality data in England (2017-2019) to explore life expectancy among people with or without intellectual disabilities, indicated by the presence or absence, respectively, of: epilepsy; incontinence; severe visual loss; severe visual impairment; severe mobility difficulties; cerebral palsy and PEG feeding. Life expectancy and 95% confidence intervals were compared using flexible parametric methods. Read More

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A peptide blocking the ADORA1-neurabin interaction is anticonvulsant and inhibits epilepsy in an Alzheimer's model.

JCI Insight 2022 Jun 8;7(11). Epub 2022 Jun 8.

Departments of Cell, Developmental and Integrative Biology.

Epileptic seizures are common sequelae of stroke, acute brain injury, and chronic neurodegenerative diseases, including Alzheimer's disease (AD), and cannot be effectively controlled in approximately 40% of patients, necessitating the development of novel therapeutic agents. Activation of the A1 receptor (A1R) by endogenous adenosine is an intrinsic mechanism to self-terminate seizures and protect neurons from excitotoxicity. However, targeting A1R for neurological disorders has been hindered by side effects associated with its broad expression outside the nervous system. Read More

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A Comparison of Epileptogenic Effect of Status Epilepticus Treated With Diazepam, Midazolam, and Pentobarbital in the Mouse Pilocarpine Model of Epilepsy.

Front Neurol 2022 20;13:821917. Epub 2022 May 20.

Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Status epilepticus (SE) is a medical emergency associated with acute severe systemic damage and high mortality. Moreover, symptomatic SE is one of the highest risk factors for epileptogenesis. While the antiepileptic drugs (AEDs) are chosen in favor of acute control of SE, the potential short-term and long-term effects of such AEDs have been ignored in clinics. Read More

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Idling for Decades: A European Study on Risk Factors Associated with the Delay Before a Narcolepsy Diagnosis.

Nat Sci Sleep 2022 31;14:1031-1047. Epub 2022 May 31.

Center for Sleep Medicine, Sleep Research and Epileptology, Klinik Barmelweid AG, Barmelweid, Aargau, Switzerland.

Purpose: Narcolepsy type-1 (NT1) is a rare chronic neurological sleep disorder with excessive daytime sleepiness (EDS) as usual first and cataplexy as pathognomonic symptom. Shortening the NT1 diagnostic delay is the key to reduce disease burden and related low quality of life. Here we investigated the changes of diagnostic delay over the diagnostic years (1990-2018) and the factors associated with the delay in Europe. Read More

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SRF in Neurochemistry: Overview of Recent Advances in Research on the Nervous System.

Neurochem Res 2022 Jun 7. Epub 2022 Jun 7.

Laboratory of Molecular Neurobiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Serum response factor (SRF) is a representative transcription factor that plays crucial roles in various biological phenomena by regulating immediate early genes (IEGs) and genes related to cell morphology and motility, among others. Over the years, the signal transduction pathways activating SRF have been clarified and SRF-target genes have been identified. In this overview, we initially briefly summarize the basic biology of SRF and its cofactors, ternary complex factor (TCF) and megakaryoblastic leukemia (MKL)/myocardin-related transcription factor (MRTF). Read More

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Automated classification of cyclic alternating pattern sleep phases in healthy and sleep-disordered subjects using convolutional neural network.

Comput Biol Med 2022 Jul 10;146:105594. Epub 2022 May 10.

Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore, 599489, Singapore; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan; Department of Biomedical Engineering, School of Science and Technology, Singapore University of Social Sciences, 599491, Singapore. Electronic address:

Sleep contributes to more than a third of a person's life, making sleep monitoring essential for overall well-being. Cyclic alternating patterns (CAP) are crucial in monitoring sleep quality and associated illnesses such as insomnia, nocturnal frontal lobe epilepsy (NFLE), narcolepsy, etc. However, traditionally medical specialists practice manual division techniques of CAP phases which are sensitive to human weariness and inaccuracies. Read More

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Association of cognitive enhancers and incident seizure risk in dementia: a population-based study.

BMC Geriatr 2022 06 3;22(1):480. Epub 2022 Jun 3.

Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Although individuals with dementia have a high risk of developing seizures, whether seizures are associated with cholinesterase inhibitors, which are commonly prescribed to treat individuals with dementia, remains unknown. This study investigated the risk of incident seizure following cholinesterase inhibitor use in patients with dementia.

Methods: A nationwide, nested case-control study was conducted using data from the Korean Health Insurance Review and Assessment Service (HIRA) from 2014 through 2018. Read More

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Sulphonylurea for Improving Neurological Features in Neonatal Diabetes: a systematic review and meta-analyses.

Pediatr Diabetes 2022 Jun 3. Epub 2022 Jun 3.

Pediatric Endocrinology, Gynaecology and Diabetology, Centre de Référence des Pathologies Gynécologiques Rares et des Maladies Endocriniennes Rares de la Croissance et du Développement, Hôpital Universitaire Necker Enfants Malades, Université de Paris, Paris, France.

Background: In monogenic diabetes due to KCNJ11 and ABCC8 mutations that impair KATP- channel function, sulphonylureas improve long-term glycaemic control. Although KATP channels are extensively expressed in the brain, the effect of sulphonylureas on neurological function has varied widely. We evaluated published evidence about potential effects of sulphonylureas on neurological features, especially epilepsy, cognition, motor function and muscular tone, visuo-motor integration, and attention deficits in children and adults with KCNJ11 and ABCC8-related neonatal-onset diabetes mellitus. Read More

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Complex effects on Ca2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder.

Sci Rep 2022 Jun 2;12(1):9186. Epub 2022 Jun 2.

Departments of Pathology/Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Room 208A, Baltimore, MD, 21201, USA.

P/Q-type Ca currents mediated by Ca2.1 channels are essential for active neurotransmitter release at neuromuscular junctions and many central synapses. Mutations in CACNA1A, the gene encoding the principal Ca2. Read More

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Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels.

Elife 2022 Jun 1;11. Epub 2022 Jun 1.

Department of Medicine, Miller School of Medicine, University of Miami, Miami, United States.

Neuronal KCNQ channels mediate the M-current, a key regulator of membrane excitability in the central and peripheral nervous systems. Mutations in KCNQ2 channels cause severe neurodevelopmental disorders, including epileptic encephalopathies. However, the impact that different mutations have on channel function remains poorly defined, largely because of our limited understanding of the voltage-sensing mechanisms that trigger channel gating. Read More

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Functional correlates of clinical phenotype and severity in recurrent SCN2A variants.

Commun Biol 2022 05 30;5(1):515. Epub 2022 May 30.

Ion Channels and Human Diseases Group, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3052, Australia.

In SCN2A-related disorders, there is an urgent demand to establish efficient methods for determining the gain- (GoF) or loss-of-function (LoF) character of variants, to identify suitable candidates for precision therapies. Here we classify clinical phenotypes of 179 individuals with 38 recurrent SCN2A variants as early-infantile or later-onset epilepsy, or intellectual disability/autism spectrum disorder (ID/ASD) and assess the functional impact of 13 variants using dynamic action potential clamp (DAPC) and voltage clamp. Results show that 36/38 variants are associated with only one phenotypic group (30 early-infantile, 5 later-onset, 1 ID/ASD). Read More

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A Novel Pathway Phenotype of Temporal Lobe Epilepsy and Comorbid Psychiatric Disorders: Results of Precision Nomothetic Medicine.

Antioxidants (Basel) 2022 Apr 20;11(5). Epub 2022 Apr 20.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

No precision medicine models of temporal lobe epilepsy (TLE) and associated mental comorbidities have been developed to date. This observational study aimed to develop a precision nomothetic, data-driven comorbid TLE model with endophenotype classes and pathway phenotypes that may have prognostic and therapeutical implications. We recruited forty healthy controls and 108 TLE patients for this research and assessed TLE and psychopathology (PP) features as well as oxidative stress (OSTOX, e. Read More

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Henri Legrand du Saulle's 1873 book: "La Folie Héréditaire" (hereditary madness).

Am J Med Genet B Neuropsychiatr Genet 2022 Apr 23;189(3-4):51-59. Epub 2022 May 23.

Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia, USA.

In his 1873 monograph "La Folie Héréditaire," the French Alienist Legrand du Saulle (LdS) first outlined his understanding of hereditary factors in insanity and then described in detail the theory of Hereditary Madness (HM) that emerged from the writings of his mentor Bénédict Morel. This form of insanity was thought to arise only in families with neuropathic traits. Degeneration theory, proposed by Morel, postulated a within-family "evolution" of increasingly severe psychopathology, typically beginning with mild neuropathic traits and associated idiosyncrasies, and progressing over generations to hereditary madness, mental retardation, epilepsy, and eventual sterility. Read More

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[The Greek-Roman physician Galen of Pergamum and his neurological case histories].

Authors:
Werner Golder

Nervenarzt 2022 May 23. Epub 2022 May 23.

, 23 rue de l'Oriflamme, 84000, Avignon, Frankreich.

Background: The case histories in the writings of Galen of Pergamum have so far been interpreted primarily in literary and socio-historic terms. The analysis focused on the medical aspects is still incomplete.

Question: Which neurological competences do the galenic case reports communicate?

Material And Methods: The 400 galenic case histories were studied for anamnestic, clinical, therapeutic, and prognostic statements on neurological and psychiatric diseases. Read More

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Clinical features and outcomes of leucine-rich glioma-inactivated protein 1 and contactin protein-like 2 antibody-associated autoimmune encephalitis in a Chinese cohort.

J Clin Neurosci 2022 Jul 18;101:137-143. Epub 2022 May 18.

Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

The present study aimed to investigate the clinical manifestations, epidemiological characteristics, and outcomes of Chinese patients with voltage-gated potassium channel complex (VGKC) antibody-associated encephalitis. Patients diagnosed with VGKC antibody-associated encephalitis at our institution between January 2016 and December 2020 were included in this study. We retrospectively evaluated their clinical features, auxiliary examination results, treatments details, long-term outcomes, and risk factors for poor outcome. Read More

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Inconsistent Medicaid Coverage is Associated with Negative Health Events for People with Epilepsy.

J Health Care Poor Underserved 2022 ;33(2):1036-1053

Objective: Examine the association between gaps in Medicaid coverage and negative health events (NHEs) for people with epilepsy (PWE).

Methods: Using five years of Medicaid claims for PWE, we identified gaps in Medicaid coverage. We used logistic regression to evaluate the association between a gap in coverage and being in the top quartile of NHEs and factors associated with having a gap. Read More

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Role of the pathologist in the diagnosis of autoimmune encephalitis.

Indian J Pathol Microbiol 2022 May;65(Supplement):S198-S206

Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Autoimmune encephalitis is a group of non-infectious immune-mediated inflammatory disorders manifesting with epilepsy and encephalitis syndromes that are associated with autoantibodies in the serum and/or cerebrospinal fluid (CSF). Pathogenic autoantibodies have been discovered against intracellular onconeural antigens, surface neuronal, or synaptic antigens with distinctive pathogenesis that underlie differences in response to immunotherapy. The onconeural antigens incite cytotoxic T-cell-mediated neuronal destruction, whereas surface antigens trigger direct damage by autoantibodies via complement mediated pathways, and hence respond well to immunomodulatory therapy, in contrast to poor response in the former. Read More

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Neuroprotective effects of glucagon-like peptide-1 (GLP-1) analogues in epilepsy and associated comorbidities.

Neuropeptides 2022 May 10;94:102250. Epub 2022 May 10.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Epilepsy is a common neurological condition induced by losing equilibrium of different pathway as well as neurotransmitters that affects over 50 million people globally. Furthermore, long-term administration of anti-seizure medications has been associated with psychological adverse effects. Also, epilepsy has been related to an increased prevalence of obesity and called type 2 diabetes mellitus. Read More

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mutations in intellectual disability and epilepsy: A report of 2 cases and literature review.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Feb;47(2):265-270

Department of Pediatrics, Xiangya Hospital, Central South University; Research Center of Children Intellectual Disability of Hunan Province, Changsha 410008, China.

More than 100 genes located on the X chromosome have been found to be associated with X-linked intellectual disability (XLID) to date, and is a pathogenic gene for XLID. In addition to intellectual disability, patients with gene mutation can also have other neurological symptoms, such as epilepsy, abnormal behavior, and hypotonia, as well as abnormalities of other systems. Two children with intellectual disability and epilepsy caused by gene mutation were treated in the Department of Pediatrics, Xiangya Hospital, Central South University from March 8, 2017 to June 20, 2020. Read More

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February 2022

FIRDA, refractory epilepsy, and SEEG guided RF: a case report.

Epilepsia Open 2022 May 9. Epub 2022 May 9.

Assuta Medical Center, Functional Neurosurgerie Group, Tel Aviv, IL.

Objectives: We will demonstrate that FIRDA (frontal intermittent rhythmic delta activity) - otherwise related to systemic disorders and encephalopathy - has a role as an epileptic biomarker of deep seated midline SOZ. Its abolishment following SEEG guided radiofrequency of such SOZ correlates with clinical improvement, suggests its role as a non-invasive biomarker of otherwise inaccessible SOZs.

Methods: We report the case of AK who was admitted with "psychiatric and gastrointestinal complaints". Read More

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