5,071 results match your criteria Psychiatric Disorders Associated With Epilepsy


The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy.

Elife 2019 Feb 22;8. Epub 2019 Feb 22.

Neurobiology Section and Center for Neural Circuits and Behavior, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.

In epilepsy, brain networks generate pathological high-frequency oscillations (pHFOs) during interictal periods. To understand how pHFOs differ from normal oscillations in overlapping frequency bands and potentially perturb hippocampal processing, we performed high-density single unit and local field potential recordings from hippocampi of behaving rats with and without chronic epilepsy. In epileptic animals, we observed two types of co-occurring fast oscillations, which by comparison to control animals we could classify as 'ripple-like' or 'pHFO'. Read More

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http://dx.doi.org/10.7554/eLife.42148DOI Listing
February 2019

Are psychogenic nonepileptic seizures risk factors for a worse outcome in patients with refractory mesial temporal epilepsy submitted to surgery? Results of a retrospective cohort study.

Epilepsy Behav 2019 Feb 16;93:12-15. Epub 2019 Feb 16.

Department of Psychiatry and Medical Psychology, Faculdade de Medicina de São José do Rio Preto (FAMERP), Brazil. Electronic address:

Objective: The objective of this study was to verify if the presence of psychogenic nonepileptic seizures (PNES) could be a risk factor precluding corticoamygdalohippocampectomy (CAH) in patients with refractory temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS) (TLE-MTS).

Methods: This retrospective cohort study analyzed medical data of patients with refractory TLE-MTS accompanied in a Brazilian epilepsy surgery center. Presurgical psychiatric evaluations were performed using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.036DOI Listing
February 2019

[Oxidative stress in epilepsy].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):97-101

City Clinical Hospital #13, Moscow, Russia.

This article contains an analysis of clinical and experimental studies in which oxidative stress is considered as a possible mechanism in the pathogenesis of epilepsy. Oxidative stress occurs as a result of brain damage after epileptic seizures and may later cause epileptogenesis. Patients with epilepsy showed a high level of lipid peroxidation markers, while the activity of antioxidant defense system was low. Read More

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http://dx.doi.org/10.17116/jnevro201911901197DOI Listing
January 2019

A scoping review of health-related stigma outcomes for high-burden diseases in low- and middle-income countries.

BMC Med 2019 Feb 15;17(1):17. Epub 2019 Feb 15.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Background: Stigma is associated with health conditions that drive disease burden in low- and middle-income countries (LMICs), including HIV, tuberculosis, mental health problems, epilepsy, and substance use disorders. However, the literature discussing the relationship between stigma and health outcomes is largely fragmented within disease-specific siloes, thus limiting the identification of common moderators or mechanisms through which stigma potentiates adverse health outcomes as well as the development of broadly relevant stigma mitigation interventions.

Methods: We conducted a scoping review to provide a critical overview of the breadth of research on stigma for each of the five aforementioned conditions in LMICs, including their methodological strengths and limitations. Read More

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http://dx.doi.org/10.1186/s12916-019-1250-8DOI Listing
February 2019
1 Read

Congenital CLN8 disease of neuronal ceroid lipofuscinosis: a novel phenotype.

Rev Neurol 2019 Feb;68(4):155-159

Hospital de Ninos de la Santisima Trinidad, Cordoba, Argentina.

Introduction: CLN8 disease is one of the thirteen recognized genetic types of neuronal ceroid lipofuscinosis, a group of neurodegenerative lysosomal storage disorders, most frequent in childhood. A putative 286 amino acids transmembrane CLN8 protein with unknown function is affected. Pathological variants in the CLN8 gene were associated with two different phenotypes: variant late-infantile in individuals from many countries worldwide, and epilepsy progressive with mental retardation, appearing in Finnish and Turkish subjects. Read More

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February 2019
3 Reads

Clinical spectrum of -related epileptic disorders.

Neurology 2019 Feb 8. Epub 2019 Feb 8.

From the University of Tübingen (S. Wolking, J.M., Y.G.W., H.L., J.S.), Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, Tübingen, Germany; Luxembourg Centre for Systems Biomedicine (P.M.), University of Luxembourg, Esch-sur-Alzette; Pediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G., C.M.), Children's Hospital Anna Meyer, University of Florence, Italy; Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Services (R.S.M.), University of Southern Denmark, Odense; Department of Clinical and Experimental Epilepsy (S.B.), UCL Institute of Neurology and Epilepsy Society, UK, London; Division of Neurology (K.L.H., I.H.), Children's Hospital of Philadelphia, PA; Department of Pediatric Neurology (C.D.A.), Centre de Compétences Maladies Rares, CHU Besançon; Service de Génétique (N.C.), Hospices Civils des Lyon, Bron; GENDEV Team (N.C.), Neurosciences Research Center of Lyon, Bron, France; Neuropediatric Clinic and Clinic for Neurorehabilitation (K.S.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Beaumont Hospital (P.W.-W.), Dublin, Ireland; Department of Pediatrics, Division of Medical Genetics, Institute of Human Genetics (B.A.M.), Departments of Neurology and Pediatrics (A.N.), and Departments of Neurology and Pediatrics, and Institute of Human Genetics (M.R.C.), University of California, San Francisco; Department of Neurology (W.V.P.), University Hospitals Leuven, Belgium; Department of Pediatrics (L.L.S.), Hvidovre Hospital, Denmark; King's College Hospital (S.O., E.H., S.G., D.K.P.), London; Evelina London Children's Hospital (S.O., E.H., S.G.), London, UK; Section of Genetics (K.B., M.S.S.), Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora; Clinique Bernoise Montana (T.D.), Crans-Montana, Switzerland; Department of Neuropediatrics (H.M.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics (A.T.P., S.J.L.K., J.C.T.) and Department of Oncology (D.V.V.), University of Oxford, UK; Epilepsy Center (M.P.C.), Health Sciences Department, San Paolo Hospital, University of Milan; Child Neuropsychiatry (F.D.), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Italy; Departments of Neurology and Clinical Genomics (R.H.G.) and Health Sciences Research and Clinical Genomics (E.W.K., C.K.), Mayo Clinic, Rochester, MN; Ambry Genetics (Z.P.), Aliso Viejo, CA; Department of Clinical Neuroscience (S.T.), King's College London; New Medicines (M.A., D.M.), UCB Pharma, Slough, UK; Neuropediatric Clinic and Clinic for Neurorehabilitation (G.J.K.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Research Institute for Rehabilitation, Transition and Palliation (G.J.K.), PMU Salzburg, Austria; Department of Neurology (D.H.L.), University of California, San Francisco; Neurogenetics Group (S. Weckhuysen), Center for Molecular Neurology, VIB, Antwerp; Laboratory of Neurogenetics (S. Weckhuysen), Institute Born-Bunge, University of Antwerp; Department of Neurology (S. Weckhuysen), Antwerp University Hospital, Antwerp, Belgium; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (D.K.P.), MRC Centre for Neurodevelopmental Disorders (D.K.P.), King's College London, UK; Evelina London Children's Hospital (D.K.P.), London, UK; Department of Neuropediatrics (I.H.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; Institute of Neuroscience (R.H.T.), Henry Wellcome Building, Newcastle University; Neurology Research Group (M.I.R.), Institute of Life Science, Swansea University Medical School, Swansea, UK; Service de Génétique (G.L.), Hospices Civils des Lyon, Bron; GENDEV Team (G.L.), Neurosciences Research Center of Lyon, Bron, France; NIHR University College London Hospitals Biomedical Research Centre (S.M.S.), UCL Institute of Neurology, London, UK; Cologne Center for Genomics (D.L.), University of Cologne, Germany; Stanley Center for Psychiatric Research (D.L.) and Program in Medical and Population Genetics (D.L.), Broad Institute of MIT and Harvard, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit (D.L.), Massachusetts General Hospital and Harvard Medical School, Boston.

Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to , encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants.

Methods: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007089DOI Listing
February 2019
1 Read

Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy.

Behav Neurol 2019 14;2019:4139404. Epub 2019 Jan 14.

Neurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy.

Objectives: The findings of previous studies focused on personality disorders in epileptic patients are difficult to interpret due to nonhomogeneous samples and noncomparable methods. Here, we aimed at studying the personality profile in patients with mild temporal lobe epilepsy (mTLE) with psychiatric comorbidity.

Materials And Methods: Thirty-five patients with mTLE (22 males, mean age 40. Read More

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https://www.hindawi.com/journals/bn/2019/4139404/
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http://dx.doi.org/10.1155/2019/4139404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348858PMC
January 2019
5 Reads

Prevalence of neuropsychiatric symptoms associated with malformations of cortical development.

Epilepsy Behav 2019 Feb 4;92:306-310. Epub 2019 Feb 4.

Department of Psychiatry, McGill University Health Centre, McGill University, Montreal, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada.

Purpose: Malformations of cortical development (MCD) are structural abnormality of the cortex or brain parenchyma with diverse clinical manifestations. Little is known about the association of psychiatric and behavioral problems in MCD. We aimed to determine prevalence and risk factors of neuropsychiatric symptoms in a cohort of adult patients with MCD. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.011DOI Listing
February 2019
1 Read

Clinical and electroencephalographic correlates of psychiatric features in children with frontal lobe epilepsy.

Epilepsy Behav 2019 Feb 4;92:283-289. Epub 2019 Feb 4.

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy. Electronic address:

Background And Objective: Frontal lobe epilepsy (FLE) is often associated with psychiatric features, although the factors predisposing to the concurrence of these conditions have yet to be determined, especially in younger children. We aimed at defining possible clinical and electroencephalography (EEG) features that may enhance the psychiatric risk in pediatric FLE.

Method: We performed a structured psychiatric assessment of 59 children with FLE, using both categorical and dimensional approaches, correlated psychopathology with epilepsy data, and cognitive development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183070
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http://dx.doi.org/10.1016/j.yebeh.2019.01.008DOI Listing
February 2019
3 Reads

Levetiracetam-Associated Psychogenic Non-epileptic Seizures; A Hidden Paradox.

J Popul Ther Clin Pharmacol 2018 Jul 11;25(2):e1-e11. Epub 2018 Jul 11.

Dept of Neurology, Nizam's Institute of Medical Sciences, Hyderabad 500 082 India.

Objectives To study the clinical profile and outcome in patients with epilepsy who developed psychogenic non-epileptic seizures (PNES) associated with levetiracetam (LEV) use.   Methods In this prospective observational study, conducted over 1 year, 13 patients with epilepsy and PNES, documented by video electroencephalogram (VEEG) while on LEV, were included. Those with past history of psychiatric illnesses were excluded. Read More

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http://dx.doi.org/10.22374/1710-6222.25.2.1DOI Listing
July 2018
3 Reads

Beyond Trauma: A Multiple Pathways Approach to Auditory Hallucinations in Clinical and Nonclinical Populations.

Schizophr Bull 2019 Feb;45(Supplement_1):S24-S31

School of Psychological Science, University of Western Australia, Perth, Western Australia, Australia.

That trauma can play a significant role in the onset and maintenance of voice-hearing is one of the most striking and important developments in the recent study of psychosis. Yet the finding that trauma increases the risk for hallucination and for psychosis is quite different from the claim that trauma is necessary for either to occur. Trauma is often but not always associated with voice-hearing in populations with psychosis; voice-hearing is sometimes associated with willful training and cultivation in nonclinical populations. Read More

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http://dx.doi.org/10.1093/schbul/sby110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357973PMC
February 2019
1 Read

Epilepsy and Sleep Related Breathing Disturbances.

Chest 2019 Jan 31. Epub 2019 Jan 31.

Director, Cleveland Clinic Sleep Disorders Center, Cleveland, OH, US. Electronic address:

Epilepsy is the fourth most common neurological disorder in the US, affecting over 2.2 million people. Epilepsy is associated with a number of medical and psychiatric comorbidities, higher health care utilization, cost and substantial economic burden. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193006
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http://dx.doi.org/10.1016/j.chest.2019.01.016DOI Listing
January 2019
4 Reads

[A role of inflammasomes in the pathogenesis of neurological and mental diseases].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(12):81-91

Sechenov First Moscow State Medical University of the MH, Moscow, Russia.

Inflammasomes are macromolecular complexes that contain many copies of receptors recognizing molecular patterns of pathogenic agents (PAMP) and damage-associated structures (DAMP), and also include molecules of adapter protein ASC and procaspase-1. Activation of inflammasomes leads to the formation of active caspase-1 that, in turn, provides the maturation of pro-IL-1β and pro-IL-18 to IL-1β and IL-18. The latter cytokines play an important role in control of neuroinlfammation in the central nervous system contributing to the pathogenesis of a series of neurological, neurodegenerative and mental disorders. Read More

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http://dx.doi.org/10.17116/jnevro201811812181DOI Listing
January 2018
1 Read

Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region.

Epilepsia 2019 Jan 25. Epub 2019 Jan 25.

Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.

Objective: To characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype-protein structure-phenotype relationships.

Methods: We evaluated the phenotypes of 14 patients with GNAO1 variants, analyzed their variants for potential pathogenicity, and mapped them, along with those in the literature, on a three-dimensional structural protein model.

Results: The 14 patients in our cohort, including one sibling pair, had 13 distinct, heterozygous GNAO1 variants classified as pathogenic or likely pathogenic. Read More

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http://dx.doi.org/10.1111/epi.14653DOI Listing
January 2019
1 Read

Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy.

Epilepsia 2019 Feb 25;60(2):284-293. Epub 2019 Jan 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: Attention-deficit/hyperactivity disorder (ADHD) affects 10%-30% of individuals with epilepsy, yet concerns remain regarding the safety of ADHD medication in this group. The objective of this study was to examine the risk of acute seizures associated with ADHD medication in individuals with epilepsy.

Methods: A total of 21 557 individuals with a seizure history born between 1987 and 2003 were identified from Swedish population registers. Read More

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http://dx.doi.org/10.1111/epi.14640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365170PMC
February 2019
4.571 Impact Factor

Transient Cognitive Impairment in Epilepsy.

Front Mol Neurosci 2018 7;11:458. Epub 2019 Jan 7.

NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy.

Impairments of the dialog between excitation and inhibition (E/I) is commonly associated to neuropsychiatric disorders like autism, bipolar disorders and epilepsy. Moderate levels of hyperexcitability can lead to mild alterations of the EEG and are often associated with cognitive deficits even in the absence of overt seizures. Indeed, various testing paradigms have shown degraded performances in presence of acute or chronic non-ictal epileptiform activity. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330286PMC
January 2019
1 Read

Long-term, targeted delivery of GDNF from encapsulated cells is neuroprotective and reduces seizures in the pilocarpine model of epilepsy.

J Neurosci 2019 Jan 21. Epub 2019 Jan 21.

Department of Medical Science, Section of Pharmacology, Neuroscience Center, University of Ferrara and National Institute of Neuroscience, Ferrara, Italy.

Neurotrophic factors are candidates for treating epilepsy but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region. We have developed an encapsulated cell technology that overcomes these obstacles by providing a targeted, continuous, de novo synthesized source of high levels of neurotrophic molecules from human clonal ARPE-19 cells encapsulated into hollow fiber membranes. Here we illustrate the potential of this approach for delivering glial cell line-derived neurotrophic factor (GDNF) directly to the hippocampus of epileptic rats. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0435-1
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http://dx.doi.org/10.1523/JNEUROSCI.0435-18.2018DOI Listing
January 2019
5 Reads

Disrupted cortico-ponto-cerebellar pathway in patients with hemimegalencephaly.

Brain Dev 2019 Jan 18. Epub 2019 Jan 18.

Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.

Objective: Cerebellar dysmaturation and injury is associated with a wide range of neuromotor, neurocognitive and behavioral disorders as well as with preterm birth. We used diffusion tensor MR imaging to investigate a disruption in structural cortico-ponto-cerebellar (CPC) connectivity in children with infantile-onset severe epilepsy.

Methods: We performed CPC tract reconstructions in 24 hemimegalencephaly (HME) patients, 28 West syndrome (WS) of unknown etiology patients, and 25 pediatric disease control subjects without a history of epilepsy nor brain abnormality on MRI. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.01.002DOI Listing
January 2019

Prevalence, correlates for early neurological disorders and association with functioning among children and adolescents with HIV/AIDS in Uganda.

BMC Psychiatry 2019 Jan 21;19(1):34. Epub 2019 Jan 21.

Mental Health Project, MRC/UVRI and LSHTM Uganda Research Unit, P. O. Box 49, Entebbe, Uganda.

Background: The aim of this study was to determine the prevalence of neurological disorders and their associated correlates and relations with clinical and behavioural problems among children and adolescents with HIV/AIDS (CA-HIV).

Methods: This study involved a sample of 1070 CA-HIV/caregiver dyads who were evaluated at their 6-month follow-up visit as part of their participation in the longitudinal study, 'Mental health among HIV infected CHildren and Adolescents in KAmpala and Masaka, Uganda (the CHAKA study)'. Participants completed an extensive battery of measures that included a standardized DSM-5- referenced rating scale, the parent version (5-18 years) of the Child and Adolescent Symptom Inventory-5 (CASI-5). Read More

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http://dx.doi.org/10.1186/s12888-019-2023-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341558PMC
January 2019

Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease).

Nutrients 2019 Jan 15;11(1). Epub 2019 Jan 15.

Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159c Nowoursynowska Str., 02-776 Warsaw, Poland.

The goal of this review was to assess the effectiveness of ketogenic diets on the therapy of neurodegenerative diseases. The ketogenic diet is a low-carbohydrate and fat-rich diet. Its implementation has a fasting-like effect, which brings the body into a state of ketosis. Read More

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http://dx.doi.org/10.3390/nu11010169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356942PMC
January 2019
3 Reads

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.

JAMA Netw Open 2019 Jan 4;2(1):e186606. Epub 2019 Jan 4.

The National Centre for Register-Based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark.

Importance: Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and many other neurological and psychiatric disorders. Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD).

Objective: To determine whether prenatal exposure to valproate and other AEDs is associated with an increased risk of ADHD in the offspring. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.6606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324310PMC
January 2019
9 Reads

, a Candidate Gene for Psychiatric and Neurological Disorders.

Authors:
Ming Li Weihua Yue

Mol Neuropsychiatry 2018 Dec 7;4(3):119-133. Epub 2018 Nov 7.

Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.

Recent large-scale genetic approaches, such as genome-wide association studies, have identified multiple genetic variations that contribute to the risk of mental illnesses, among which single nucleotide polymorphisms (SNPs) within or near the vaccinia related kinase 2 () gene have gained consistent support for their correlations with multiple psychiatric and neurological disorders including schizophrenia (SCZ), major depressive disorder (MDD), and genetic generalized epilepsy. For instance, the genetic variant rs1518395 in showed genome-wide significant associations with SCZ (35,476 cases and 46,839 controls, = 3.43 × 10) and MDD (130,620 cases and 347,620 controls, = 4. Read More

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http://dx.doi.org/10.1159/000493941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323383PMC
December 2018
3 Reads

Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015.

BMC Pharmacol Toxicol 2019 Jan 14;20(1). Epub 2019 Jan 14.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Ouhai District, Wenzhou, Zhejiang Province, People's Republic of China.

Background: This active, open observational study aimed to investigate adverse drug reactions (ADRs) associated with six commonly used antiepileptic drugs (AEDs) in southern Chinese outpatients with epilepsy from 2003 to 2015.

Methods: The Wenzhou Epilepsy Follow-Up Registry Database (WEFURD) was established by a single epilepsy center in China in January 2003 to record AED efficacy and the associated ADRs by registered outpatients diagnosed with epilepsy. We reviewed the data of outpatients who had only taken one or more of six commonly used AEDs, namely, carbamazepine (CBZ), valproate (VPA), lamotrigine (LTG), oxcarbazepine (OXC), topiramate (TPM) and levetiracetam (LEV), and were registered in the WEFURD between 2003 and 2015. Read More

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https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40360-019-0285-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332546PMC
January 2019
9 Reads

Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model.

Epilepsy Behav 2019 Jan 5;92:71-78. Epub 2019 Jan 5.

Institute of Higher Nervous Activity and Neurophysiology of RAS, 117485 Butlerova 5A, Moscow, Russia.

Mood and anxiety disorders, as well as memory impairments, are important factors affecting quality of life in patients with epilepsy and can influence the antiepileptic therapy. Clinical studies of psychiatric comorbidities are quite complicated to design and interpret, so animal studies of behavioral impairments associated with seizures can be of use. We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183072
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http://dx.doi.org/10.1016/j.yebeh.2018.12.001DOI Listing
January 2019
6 Reads

Antiepileptic Drugs and Accumulation of Hospital Days Among Persons With Alzheimer's Disease.

J Am Med Dir Assoc 2019 Jan 7. Epub 2019 Jan 7.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Objectives: To compare the accumulation of hospital days between initiators and noninitiators of antiepileptic drugs (AEDs) among persons with Alzheimer's disease (AD).

Design: Exposure-matched cohort study.

Setting And Participants: Persons newly diagnosed with AD in 2005-2011 (n = 70,718) and initiating AED use identified from Finnish health care registers. Read More

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http://dx.doi.org/10.1016/j.jamda.2018.11.012DOI Listing
January 2019
2 Reads

The phenotypic landscape of a Tbc1d24 mutant mouse includes convulsive seizures resembling human early infantile epileptic encephalopathy.

Hum Mol Genet 2019 Jan 2. Epub 2019 Jan 2.

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Porter Neuroscience Research Center, National Institutes of Health, Bethesda, MD, USA.

Epilepsy, deafness, onychodystrophy, osteodystrophy and intellectual disability are associated with a spectrum of mutations of human TBC1D24. The mechanisms underlying TBC1D24-associated disorders and the functions of TBC1D24 are not well understood. Using CRISPR-Cas9 genome editing, we engineered a mouse with a premature translation stop codon equivalent to human S324Tfs*3, a recessive mutation of TBC1D24 associated with early infantile epileptic encephalopathy (EIEE). Read More

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http://dx.doi.org/10.1093/hmg/ddy445DOI Listing
January 2019

Hospital Anxiety and Depression Scale-Anxiety subscale (HADS-A) and The State-Trait Anxiety Inventory (STAI) accuracy for anxiety disorders detection in drug-resistant mesial temporal lobe epilepsy patients.

J Affect Disord 2019 03 24;246:452-457. Epub 2018 Dec 24.

Centro de Epilepsia de Santa Catarina (CEPESC), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil; Centro de Neurociências Aplicadas (CeNAp), HU, UFSC, Florianópolis, SC, Brazil; Serviço de Neurologia, HU-UFSC, Florianópolis, SC, Brazil; Departamento de Clínica Médica, HU-UFSC, Florianópolis, SC, Brazil.

Background: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is the most prevalent type of surgically remediable epilepsy and highly associated with psychiatric comorbidities. This study aimed to evaluate Hospital anxiety and depression scale-anxiety subscale (HADS-A) and The State-Trait Anxiety Inventory - Trait subscale (STAI-T) accuracy for detection of anxiety disorders in patients with drug-resistant MTLE-HS.

Methods: One hundred three consecutive patients with drug-resistant MTLE-HS were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183145
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http://dx.doi.org/10.1016/j.jad.2018.12.072DOI Listing
March 2019
12 Reads

Factors associated with depression and anxiety in children with intellectual disabilities.

J Intellect Disabil Res 2018 Dec 26. Epub 2018 Dec 26.

Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.

Background: Individuals with intellectual disabilities (ID) are at increased risk for depression and anxiety disorders; however, there is a paucity of research that pertains to associative factors for these mental health disorders in this population. The objective of this investigation was to determine factors associated with depression and anxiety problems in children with ID.

Methods: Children 6-17 years with ID (n = 423; 63% male) from the 2016 National Survey of Children's Health were included in this cross-sectional study. Read More

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http://dx.doi.org/10.1111/jir.12583DOI Listing
December 2018
2 Reads

Comprehensive cross-disorder analyses of CNTNAP2 suggest it is unlikely to be a primary risk gene for psychiatric disorders.

PLoS Genet 2018 12 26;14(12):e1007535. Epub 2018 Dec 26.

Neuroscience Research Australia, Sydney, Australia.

The contactin-associated protein-like 2 (CNTNAP2) gene is a member of the neurexin superfamily. CNTNAP2 was first implicated in the cortical dysplasia-focal epilepsy (CDFE) syndrome, a recessive disease characterized by intellectual disability, epilepsy, language impairments and autistic features. Associated SNPs and heterozygous deletions in CNTNAP2 were subsequently reported in autism, schizophrenia and other psychiatric or neurological disorders. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324819PMC
December 2018
4 Reads

Bidirectional relations among common psychiatric and neurologic comorbidities and epilepsy: Do they have an impact on the course of the seizure disorder?

Epilepsia Open 2018 Dec 20;3(Suppl Suppl 2):210-219. Epub 2018 Nov 20.

Department of Pediatrics and Children's Discovery and Innovation Institute D. Geffen School of Medicine at UCLA Los Angeles California U.S.A.

The treatment of epilepsy is not limited to the achievement of a seizure-free state. It must also incorporate the management of common psychiatric and neurologic comorbidities, affecting on average between 30 and 50% of patients with epilepsy, which have a significant impact on their lives at various levels, including quality of life and the prognosis of the seizure disorder. Mood and anxiety disorders are the most frequent psychiatric comorbidities, whereas stroke and migraine are among the more common neurologic comorbidities, migraine among the younger patients and stroke among the older patients. Read More

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http://dx.doi.org/10.1002/epi4.12278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293067PMC
December 2018

GRIN2A-related disorders: genotype and functional consequence predict phenotype.

Brain 2019 Jan;142(1):80-92

Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, Germany.

Alterations of the N-methyl-d-aspartate receptor (NMDAR) subunit GluN2A, encoded by GRIN2A, have been associated with a spectrum of neurodevelopmental disorders with prominent speech-related features, and epilepsy. We performed a comprehensive assessment of phenotypes with a standardized questionnaire in 92 previously unreported individuals with GRIN2A-related disorders. Applying the criteria of the American College of Medical Genetics and Genomics to all published variants yielded 156 additional cases with pathogenic or likely pathogenic variants in GRIN2A, resulting in a total of 248 individuals. Read More

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http://dx.doi.org/10.1093/brain/awy304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308310PMC
January 2019
1 Read

Incidence of epilepsy and associated factors in elderly patients in Germany.

Epilepsy Behav 2019 Jan 4;90:107-111. Epub 2018 Dec 4.

Epidemiology, IQVIA, Frankfurt, Germany. Electronic address:

Aims: Little is known about the recent epidemiology of epilepsy in the elderly in Germany. Therefore, the goal of this study was to analyze the incidence of epilepsy and associated factors in elderly patients followed in general practices in this country.

Methods: The incidence of epilepsy was estimated using data from all patients aged ≥60 years who were followed in 1203 general practices in Germany in 2017 (IQVIA Disease Analyzer database). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183081
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http://dx.doi.org/10.1016/j.yebeh.2018.10.035DOI Listing
January 2019
2 Reads

Childhood seizures and risk of psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study.

Lancet Child Adolesc Health 2019 Feb 7;3(2):99-108. Epub 2018 Dec 7.

National Center for Register-Based Research, Aarhus University, Aarhus, Denmark; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

Background: Paediatric seizures have been linked to psychiatric disorders in childhood, but there is a paucity of large-scale population-based studies of psychiatric comorbidity in later life. We aimed to examine the relation between childhood seizures and the risk of psychiatric disorders in adolescence and early adulthood.

Methods: We did a register-based cohort study of all individuals born in Denmark in 1978-2002. Read More

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http://dx.doi.org/10.1016/S2352-4642(18)30351-1DOI Listing
February 2019

High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.

Nat Commun 2018 12 3;9(1):5142. Epub 2018 Dec 3.

Department of Biomedical Engineering, City University of Hong Kong, 999077, Kowloon, Hong Kong SAR, China.

Technologies for mapping the spatial and temporal patterns of neural activity have advanced our understanding of brain function in both health and disease. An important application of these technologies is the discovery of next-generation neurotherapeutics for neurological and psychiatric disorders. Here, we describe an in vivo drug screening strategy that combines high-throughput technology to generate large-scale brain activity maps (BAMs) with machine learning for predictive analysis. Read More

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http://dx.doi.org/10.1038/s41467-018-07289-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277389PMC
December 2018

De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay.

PLoS Genet 2018 11 30;14(11):e1007671. Epub 2018 Nov 30.

HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America.

Mutations that alter signaling of RAS/MAPK-family proteins give rise to a group of Mendelian diseases known as RASopathies. However, among RASopathies, the matrix of genotype-phenotype relationships is still incomplete, in part because there are many RAS-related proteins and in part because the phenotypic consequences may be variable and/or pleiotropic. Here, we describe a cohort of ten cases, drawn from six clinical sites and over 16,000 sequenced probands, with de novo protein-altering variation in RALA, a RAS-like small GTPase. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291162PMC
November 2018
1 Read

Prevalence of psychiatric disorders in Thai patients with epilepsy.

Epilepsy Behav 2019 Jan 27;90:20-24. Epub 2018 Nov 27.

Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Many studies have shown that the prevalence of psychiatric disorders in patients with epilepsy (PWE) appears higher than that in general population. However, most epidemiological studies regarding psychiatric comorbidities among PWE were conducted in Western countries. This work aimed to determine the prevalence of psychiatric disorders in Thai PWE, including potential variables that could be associated with psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.004DOI Listing
January 2019
1 Read

Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing.

J Gen Physiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Cell Biology and Physiology, Washington University Medical School, St. Louis, MO

Kainate receptors are ligand-gated ion channels that have two major roles in the central nervous system: they mediate a postsynaptic component of excitatory neurotransmission at some glutamatergic synapses and modulate transmitter release at both excitatory and inhibitory synapses. Accumulating evidence implicates kainate receptors in a variety of neuropathologies, including epilepsy, psychiatric disorders, developmental delay, and cognitive impairment. Here, to gain a deeper understanding of the conformational changes associated with agonist binding and channel opening, we generate a series of Cys substitutions in the GluK2 kainate receptor subunit, focusing on the M3 helices that line the ion pore and form the bundle-crossing gate at the extracellular mouth of the channel. Read More

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http://www.jgp.org/lookup/doi/10.1085/jgp.201812234
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http://dx.doi.org/10.1085/jgp.201812234DOI Listing
November 2018
2 Reads

Improvement of Hypothalamic Hamartoma-Related Psychiatric Disorder After Stereotactic Laser Ablation: Case Report and Review of Literature.

World Neurosurg 2019 Feb 24;122:680-683. Epub 2018 Nov 24.

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Department of Neurosurgery, Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address:

Background: Hypothalamic hamartomas (HHs) are nonneoplastic congenital malformations associated with refractory epilepsy and behavioral disorders. Improvement in behavioral functioning following resection of HHs has been reported. Stereotactic laser ablation (SLA), a minimally invasive technique, has been used for the treatment of HH-related epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183272
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http://dx.doi.org/10.1016/j.wneu.2018.11.166DOI Listing
February 2019
8 Reads

Experiences of self-conscious emotions in temporal lobe epilepsy.

Epilepsy Behav 2019 Jan 23;90:1-6. Epub 2018 Nov 23.

Univ. Lille, Inserm, CHU Lille, U1171 - Degenerative & Vascular Cognitive Disorders, Lille, France; Memory Resource and Research Center, Lille University Medical Center, Lille, France.

Self-conscious emotions (SCEs) with a negative valence (such as shame and guilt) or a positive valence (such as pride) are moral emotions that emerge from self-reflection and self-evaluation processes in social contexts. In some neurologic and psychiatric disorders, experiences of SCEs are dysregulated. The objectives of the present study were to (i) evaluate whether patients with temporal lobe epilepsy (TLE) experience SCEs in the same way as nonclinical (control) participants and (ii) probe the relationships between experiences of SCEs on the one hand and the psychological symptoms frequently diagnosed in patients with TLE (anxiety and depression), the patients' clinical characteristics, and their functional outcomes in everyday life on the other. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183053
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http://dx.doi.org/10.1016/j.yebeh.2018.10.028DOI Listing
January 2019
15 Reads

Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force.

Epilepsia Open 2018 Nov 26;3(Suppl Suppl 1):13-23. Epub 2018 Jul 26.

The Nathan Kline Institute for Psychiatric Research Orangeburg New York U.S.A.

Common data elements (CDEs) are becoming more common as more areas of preclinical research have generated CDEs. Herein we provide an overview of the progress to date in generating CDEs for preclinical epilepsy research. Currently there are CDEs that have been developed for Physiology (in vivo), Behavior, Pharmacology, and Electroencephalography (EEG). Read More

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http://doi.wiley.com/10.1002/epi4.12234
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http://dx.doi.org/10.1002/epi4.12234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210047PMC
November 2018
5 Reads

Factors underlying the development of chronic temporal lobe epilepsy in autoimmune encephalitis.

J Neurol Sci 2019 Jan 30;396:102-107. Epub 2018 Oct 30.

Epilepsy Unit, Department of Neurosciences/Mental Health, "Sapienza" University, Rome, Italy. Electronic address:

Purpose: Limbic encephalitis (LE) is an autoimmune condition characterized by amnestic syndrome, psychiatric features and seizures. Early diagnosis and prompt treatment are crucial to avoid long-term sequelae, including psycho-cognitive deficits and persisting seizures. The aim of our study was to analyze the characteristics of 33 LE patients in order to identify possible prognostic factors associated with the development of chronic epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X183044
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http://dx.doi.org/10.1016/j.jns.2018.10.026DOI Listing
January 2019
21 Reads
2.474 Impact Factor

Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.

Front Mol Neurosci 2018 23;11:387. Epub 2018 Oct 23.

Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, United States.

Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are sorely needed to address these complex diseases. The metabotropic glutamate receptors are a class of G protein-coupled receptors that act to modulate neurotransmission across many brain structures. Read More

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00387
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http://dx.doi.org/10.3389/fnmol.2018.00387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206046PMC
October 2018
14 Reads

Primary Causes of Hospitalizations and Procedures, Predictors of In-hospital Mortality, and Trends in Cardiovascular and Cerebrovascular Events Among Recreational Marijuana Users: A Five-year Nationwide Inpatient Assessment in the United States.

Cureus 2018 Aug 23;10(8):e3195. Epub 2018 Aug 23.

Neurology, University of Kentucky, Lexington, USA.

Background Recent trends in the legalization of marijuana in many states are increasing the popularity of recreational marijuana use. Since current data on hospitalizations in marijuana users is sparse, we evaluated the primary reasons for admissions, procedures and associated healthcare burden in hospitalized recreational marijuana users. Methods The National Inpatient Sample (NIS) for the years 2010-2014 was queried for the hospitalizations with a history of recreational marijuana usage using applicable ICD-9 CM codes. Read More

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http://dx.doi.org/10.7759/cureus.3195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200442PMC
August 2018
9 Reads

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.

ACS Chem Neurosci 2018 Nov 16. Epub 2018 Nov 16.

PET Center, Department of Radiology and Biomedical Imaging , Yale University School of Medicine , New Haven , Connecticut 06520 , United States.

Structural disruption and alterations of synapses are associated with many brain disorders including Alzheimer's disease, epilepsy, depression, and schizophrenia. We have previously developed the PET radiotracer C-UCB-J for imaging and quantification of synaptic vesicle glycoprotein 2A (SV2A) and synaptic density in nonhuman primates and humans. Here we report the synthesis of a novel radiotracer F-SDM-8 and its in vivo evaluation in rhesus monkeys. Read More

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00526
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http://dx.doi.org/10.1021/acschemneuro.8b00526DOI Listing
November 2018
22 Reads

A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease.

Eur J Pharmacol 2019 Jan 30;842:208-220. Epub 2018 Oct 30.

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Cysteinyl leukotrienes (cysLTs) are member of eicosanoid inflammatory lipid mediators family produced by oxidation of arachidonic acid by action of the enzyme 5-lipoxygenase (5-LOX). 5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.10.040DOI Listing
January 2019
5 Reads

Increased mortality and morbidity in patients with chronic hypoparathyroidism: A population-based study.

Clin Endocrinol (Oxf) 2019 Feb 20;90(2):285-292. Epub 2018 Nov 20.

Department of Medicine, University of Dundee, Dundee, UK.

Objectives: A population-based study was undertaken to determine the mortality and morbidity for people with hypoparathyroidism compared to the general population.

Methods: In this study, patients identified with chronic hypoparathyroidism using data linkage from regional datasets were compared with five age- and gender-matched controls from the general population. Data from biochemistry, hospital admissions, prescribing and the demographic dataset were linked. Read More

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http://dx.doi.org/10.1111/cen.13895DOI Listing
February 2019
5 Reads

Imaging biomarkers of behavioral impairments: A pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model.

Epilepsia 2018 Dec 28;59(12):2194-2205. Epub 2018 Oct 28.

Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany.

Objective: In patients with epilepsy, psychiatric comorbidities can significantly affect the disease course and quality of life. Detecting and recognizing these comorbidities is central in determining an optimal treatment plan. One promising tool in detecting biomarkers for psychiatric comorbidities in epilepsy is positron emission tomography (PET). Read More

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http://doi.wiley.com/10.1111/epi.14586
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http://dx.doi.org/10.1111/epi.14586DOI Listing
December 2018
10 Reads

Could nodding syndrome in Northern Uganda be a form of autism spectrum disorder? an observational study design.

Pan Afr Med J 2018 12;30:115. Epub 2018 Jun 12.

Gulu University, Faculty of Medicine, Department of Biochemistry, Gulu, Uganda.

Introduction: Nodding syndrome (NS) is associated with high anion gap, biotinidase and acetyl carnitine deficiency, vitamin B6 and D deficiency and internal displacement. The objective of this study was to conduct a metabolic analysis on NS children and review literature on its similarities with ASD.

Methods: We conducted biochemical analysis on blood and urine of NS children at Hope for HumaNs (HfH) centre in 2014 and reviewed literature on its similarities with ASD. Read More

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http://www.panafrican-med-journal.com/content/article/30/115
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http://dx.doi.org/10.11604/pamj.2018.30.115.13634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195236PMC
November 2018
8 Reads

West syndrome, developmental and epileptic encephalopathy, and severe CNS disorder associated with WWOX mutations.

Epileptic Disord 2018 Oct;20(5):401-412

Division of Neurology, Department of Pediatrics, Tawam Hospital, Al Ain, Department of Pediatrics, College of Medicine and Health Sciences UAE University, Al Ain, United Arab Emirates.

Mutations in the WWOX gene have been reported in a number of patients with various neurological disorders including spino-cerebellar ataxia, intellectual disability, epilepsy, and epileptic encephalopathy. We aimed to study the clinical, electrographic, and imaging features of two new cases with WWOX mutations and compare them to previously reported cases with WWOX mutations. We assessed two unrelated children from two consanguineous families who had severe neurological disorder including early-onset spastic quadriplegia, profound developmental delay, epilepsy, and West syndrome. Read More

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http://dx.doi.org/10.1684/epd.2018.1005DOI Listing
October 2018
83 Reads
0.900 Impact Factor

Cognitive outcomes more than 5 years after temporal lobe epilepsy surgery: Remarkable functional recovery when seizures are controlled.

Seizure 2018 Nov 29;62:116-123. Epub 2018 Sep 29.

University of Bonn, Department of Epileptology, Germany.

Purpose: Epilepsy surgery can be a successful treatment option for temporal lobe epilepsy but there are concerns about accelerated memory decline in long-term follow-up.

Method: 161 adult operated (77 right, 84 left temporal resections) versus a heterogeneous group of 208 non-operated patients with focal epilepsies were consecutively recruited and re-evaluated focusing on memory, executive functions, and vocational outcome after follow-up intervals of >5 years (5-22 years, mean 8 ± 3 years).

Results: Major losses in the operated group manifest early, at one-year follow-up. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.09.023DOI Listing
November 2018