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    [Psoriasis comorbidities].
    Cas Lek Cesk 2017 ;156(3):119-122
    Psoriasis is a chronic inflammatory skin disease affecting 2-4 % of Central European population. Nowadays, we know that psoriasis is not limited to the skin but is connected with several comorbidities like, psoriatic arthritis (around 25 %), Crohn's disease, ulcerative colitis, Bechterev, non-alcoholic liver steatosis, psychiatric disorders and mainly diseases of the so called metabolic syndrome, like diabetes mellitus type 2, arterial hypertension or dyslipidemia. In the last years, new information is arising which connect psoriasis with sleep apnoe and chronic obstructive pulmonary disease. Read More

    High Survivorship and Few Complications With Cementless Total Wrist Arthroplasty at a Mean Followup of 9 Years.
    Clin Orthop Relat Res 2017 Jul 18. Epub 2017 Jul 18.
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA.
    Background: Total wrist arthroplasty (TWA) has been described as traditionally being performed with fixation in the radius and carpus with cement. The TWA implant used in our series has been associated with promising results in studies with up to 6 years followup; however, studies evaluating survivorship, pain, and function with this implant are limited. QUESTION/PURPOSE: (1) To report ROM and pain scores after wrist reconstruction with cementless fourth-generation TWA at a mean followup of 9 years (range, 4. Read More

    The GOLMePsA study protocol: an investigator-initiated, double-blind, parallel-group, randomised, controlled trial of GOLimumab and methotrexate versus methotrexate in early diagnosed psoriatic arthritis using clinical and whole body MRI outcomes.
    BMC Musculoskelet Disord 2017 Jul 18;18(1):303. Epub 2017 Jul 18.
    Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, 2nd Floor Chapeltown Road, Leeds, West Yorkshire, LS7 4SA, UK.
    Background: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of inflammation in PsA leads to improved long-term outcomes. It is postulated that prompt intervention after diagnosis using a remission-induction treatment strategy will lead to improved outcomes and optimal disease control of PsA. Read More

    Is the SCORE chart underestimating the Real Cardiovascular (CV) Risk of patients with Psoriatic arthritis? Prevalence of subclinical CV disease detected by carotid ultrasound.
    Joint Bone Spine 2017 Jul 14. Epub 2017 Jul 14.
    Rheumatology Division, Hospital General Universitario de Elda, La Torreta, carretera Sax sn. Elda, Postal code 3600, Spain.
    Objectives: To analyse the cardiovascular risk according to the SCORE chart in a series of patients with psoriatic arthritis, and to study the presence of subclinical cardiovascular disease by carotid ultrasound.

    Methods: Cross-sectional descriptive study of patients with psoriatic arthritis attended in a tertiary hospital. The presence of classical cardiovascular risk factors and the clinical characteristics of the patients were recorded. Read More

    Exploring the existence of a stayer population with mover-stayer counting process models: application to joint damage in psoriatic arthritis.
    J R Stat Soc Ser C Appl Stat 2017 Aug;66(4):669-690
    Medical Research Council Biostatistics Unit, Cambridge, UK.
    Many psoriatic arthritis patients do not progress to permanent joint damage in any of the 28 hand joints, even under prolonged follow-up. This has led several researchers to fit models that estimate the proportion of stayers (those who do not have the propensity to experience the event of interest) and to characterize the rate of developing damaged joints in the movers (those who have the propensity to experience the event of interest). However, when fitted to the same data, the paper demonstrates that the choice of model for the movers can lead to widely varying conclusions on a stayer population, thus implying that, if interest lies in a stayer population, a single analysis should not generally be adopted. Read More

    Lipid management among individuals with inflammatory arthritis in the national REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
    J Int Med Res 2017 Jan 1:300060517713591. Epub 2017 Jan 1.
    1 Joan and Sanford I Weill Medical College of Cornell University, New York, NY, USA.
    Objective Hyperlipidemia guidelines do not currently identify inflammatory arthritis (IA) as a cardiovascular disease (CVD) risk factor. We compared hyperlipidemia treatment of individuals with and without IA (rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis) in a large national cohort. Methods Participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were classified as having IA (without diabetes or hypertension); diabetes (but no IA); hypertension (but no diabetes or IA); or no IA, diabetes, or hypertension. Read More

    Retrospective Study of Patients on Etanercept Therapy for Rheumatic Diseases in Patients With Chronic Hepatitis C Virus.
    J Clin Rheumatol 2017 Jul 11. Epub 2017 Jul 11.
    From the Section of Rheumatology, Rush University Medical Center, Chicago, IL.
    Objective: Treatment of rheumatic diseases with concurrent hepatitis C virus (HCV) infection is a therapeutic challenge. Etanercept has no known hepatotoxicity; however there is a concern for worsening of HCV infection-related liver disease due to immunosuppressive action of the drug. Here, we retrospectively assessed the safety of etanercept in rheumatologic disease in patients with chronic HCV. Read More

    Magnetic Resonance Imaging in Psoriatic Arthritis: A Descriptive Study of Indications, Features and Effect on Treatment Change.
    J Clin Rheumatol 2017 Jul 11. Epub 2017 Jul 11.
    From the *Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto Psoriatic Arthritis Clinic, Toronto Western Hospital; †Krembil Research Institute, University Health Network; Departments of ‡Medicine and §Laboratory Medicine and Pathobiology, Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
    Objective: The aims of this study were to describe the indications for, and features of, axial/peripheral joint magnetic resonance imaging (MRI) in psoriatic arthritis (PsA) and to examine the influence of MRI findings on clinical practice.

    Methods: All axial and peripheral (hand and/or foot) MRI scans on patients attending the Toronto PsA clinic l between 2003 and 2014 were included. Scan details were garnered from the radiologist's official report. Read More

    Clinical characteristics of importance to outcome in patients with axial spondyloarthritis: protocol for a prospective descriptive and exploratory cohort study.
    BMJ Open 2017 Jul 10;7(7):e015536. Epub 2017 Jul 10.
    Department of Medicine, Section of Rheumatology, Odense University Hospital, Svendborg, Denmark.
    Introduction: Spondyloarthritis (SpA) is a heterogeneous spectrum of rheumatic diseases with either predominantly axial inflammatory symptoms of the spine and sacroiliac joints or predominantly peripheral arthritis. The two main entities of axial SpA (axSpA) are ankylosing spondylitis or non-radiographic axSpA (nr-axSpA). Tumour necrosis factor-α inhibitors have revolutionised the treatment of patients with axSpA who failed to respond to non-steroidal anti-inflammatory drugs and physical therapy. Read More

    Natural Compounds for the Treatment of Psoriatic Arthritis: A Proposal Based on Multi-Targeted Osteoclastic Regulation and on a Preclinical Study.
    JMIR Res Protoc 2017 Jul 11;6(7):e132. Epub 2017 Jul 11.
    Molecular Laboratory, School of Biomedical Sciences, The University of Western Australia, Perth, Australia.
    Background: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis affecting approximately 2% to 3% of the population globally, and is characterized by both peripheral articular manifestations and axial skeletal involvement. Conventional therapies for PsA have not been fully satisfactory, though natural products (NPs) have been shown to be highly effective and represent important treatment options for psoriasis. PsA is a multigenic autoimmune disease with both environmental and genetic factors contributing to its pathogenesis. Read More

    Injection Site Reactions to Biologic Agents Used in Psoriasis and Psoriatic Arthritis.
    J Drugs Dermatol 2017 Jul;16(7):695-698

    Psoriasis is a chronic inflammatory cutaneous disease that affects 2-3% of the general population. Up to 30% of patients with psoriasis also develop psoriatic arthritis, a chronic inflammatory and progressive arthritis. Although their precise pathogeneses remain unclear, psoriasis and psoriatic arthritis involve altered expression of proinflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-12, IL-17, IL-22, and IL-23. Read More


    Drivers of Healthcare Costs Among the Costliest Patients With Psoriasis Over Three Years in a United States Health Plan.
    J Drugs Dermatol 2017 Jul;16(7):651-658

    OBJECTIVE: To compare patients with psoriasis by cost level over 3 years.

    METHODS: Psoriasis patients in a large US health plan in 2011-2013 were identified. Four groups were created by healthcare costs excluding biologics: patients having top 10% of costs in all 3 years (Top), top 10% in 2 of 3 years (High), bottom 90% in 2 of 3 years (Medium), and bottom 90% in all 3 years (Bottom). Read More


    Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis.
    Pharmacogenomics J 2017 Jul 11. Epub 2017 Jul 11.
    Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Soenderjylland, Laboratory Center, Hospital of Southern Jutland, Aabenraa, Denmark.
    Biological agents including anti-tumor necrosis factor (anti-TNF; adalimumab, infliximab, etanercept) and anti-interleukin-12/13 (IL12/23; ustekinumab) are essential for treatment of patients with severe psoriasis. However, a significant proportion of the patients do not respond to a specific treatment. Pharmacogenetics might be a way to predict treatment response. Read More

    Axial involvement according to ASAS criteria in an observational psoriatic arthritis cohort.
    Acta Reumatol Port 2017 Apr-Jun;42(2):176-182
    The definition of axial involvement in psoriatic arthritis (PsA) is still under debate. Currently, the axial spondyloarthritis (SpA) criteria defined by Assessment of Spondyloarthritis International Society (ASAS) may be the most adequate.(1) The aims of present study were to assess axial involvement according to ASAS criteria in an observational PsA cohort and define the clinical characteristics more associated with this kind of involvement. Read More

    Hyperuricemia is an independent risk factor for psoriatic arthritis in psoriatic patients.
    J Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
    Psoriatic arthritis (PsA) is a spondyloarthritic condition mainly seen in patients with psoriasis. Psoriatic patients with plaques on the scalp, gluteal fold or nail lesions are known to develop PsA more frequently, but other markers for PsA have not yet been identified. To determine which psoriatic patients are at greatest risk of developing PsA, psoriasis vulgaris (PsV) patients who visited the Department of Dermatology, Fukuoka University Hospital in 2015 were enrolled. Read More

    [Osteopecilia associated with psoriatic arthritis].
    Pan Afr Med J 2017 25;26:227. Epub 2017 Apr 25.
    Service de Rhumatologie, CHU Farhat Hached, Sousse, Tunisie.
    Osteopecilia is a benign and rare condensing osteopathy. Its association with inflammatory rheumatism is very rare. We here report the case of a 25-year old patient with skin psoriasis, presenting with groin pain of inflammatory origin. Read More

    Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis.
    Front Immunol 2017 23;8:720. Epub 2017 Jun 23.
    Laboratory of Translational Immunology, Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, Netherlands.
    Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects females three times more frequently than males. A potential role for hormones, such as prolactin (PRL), may in part explain this phenomenon. The risk of developing RA is increased in women who are lactating after the first pregnancy, which might be related to breastfeeding and the release of PRL. Read More

    Tear film and ocular surface assessment in psoriasis.
    Br J Ophthalmol 2017 Jul 8. Epub 2017 Jul 8.
    Department of Biomedical Sciences, Regional Referral Center for the Ocular Surface Diseases, University of Messina, Messina, Italy.
    Background: Psoriasis is a skin disease with also systemic involvement: its impact on the eye is not well established and often clinically underestimated. Aim of this study was to investigate the presence of ocular discomfort symptoms and of ocular surface changes in a population of patients with psoriasis.

    Methods: For this cross-sectional, comparative study, 66 patients with psoriasis were subdivided according to the presence of arthritis and to the use of biological therapy. Read More

    15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics.
    Pathol Res Pract 2017 May 19. Epub 2017 May 19.
    MVZ Fürstenberg-Karree, Berlin, Germany.
    The histopathological synovitis score evaluates the immunological and inflammatory changes of synovitis in a graduated manner generally customary for diagnostic histopathological scores. The score results from semiquantitative evaluation of the width of the synovial surface cell layer, the cell density of the stroma and the density of the inflammatory infiltration into 4 semiquantitative levels (normal 0, mild 1, moderate 2, severe 3). The addition of these values results in a final score of 0-9 out of 9. Read More

    A Survey Assessment of US Dermatologists' Perception of Biosimilars.
    J Drugs Dermatol 2017 Jun;16(6):612-615

    BACKGROUND: Biologics have transformed the treatment of psoriasis and psoriatic arthritis, but at a significant cost to payers and patients. The introduction of biosimilars into the US market could reduce costs while increasing access to biologic medications.

    OBJECTIVE: We sought to identify gaps in biosimilar knowledge and perception among US dermatologists. Read More


    Pain and pain mechanisms in patients with inflammatory arthritis: A Danish nationwide cross-sectional DANBIO registry survey.
    PLoS One 2017 7;12(7):e0180014. Epub 2017 Jul 7.
    The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
    Background: Central pain mechanisms may be prominent in subsets of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and other spondyloarthritis (SpA). The painDETECT questionnaire (PDQ) identifies neuropathic pain features, which may act as a proxy for centrally mediated pain. The objectives were to quantify and characterize pain phenotypes (non-neuropathic vs. Read More

    Role of Contrast-enhanced Ultrasound in the Evaluation of Inflammatory Arthritis.
    Chin Med J (Engl) 2017 Jul;130(14):1722-1730
    Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
    Objective: Contrast-enhanced ultrasound (CEUS) is a well-established imaging modality which has been put into clinical use in recent years with the development of second-generation contrast agent and imaging devices, and its applications in the assessment of inflammatory arthritis, such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have provoked abundant discussion and researches among radiologists and rheumatologists. To summarize the achievements of clinical studies on CEUS in the application of arthritis, and to keep up with the latest progresses of the imaging technique, we reviewed the literature in recent years, hoping to establish the role of CEUS in joint diseases.

    Data Sources: PubMed and EMBASE. Read More

    Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force.
    Ann Rheum Dis 2017 Jul 6. Epub 2017 Jul 6.
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
    Therapeutic targets have been defined for axial and peripheral spondyloarthritis (SpA) in 2012, but the evidence for these recommendations was only of indirect nature. These recommendations were re-evaluated in light of new insights. Based on the results of a systematic literature review and expert opinion, a task force of rheumatologists, dermatologists, patients and a health professional developed an update of the 2012 recommendations. Read More

    Autoimmune Disease in Children and Adolescents with Psoriasis: A Cross-Sectional Study in Denmark.
    Acta Derm Venereol 2017 Jul 6. Epub 2017 Jul 6.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.
    Psoriasis is an immune-mediated inflammatory disease, which, in studies among adults, have been shown to cluster with autoimmune disease. The aim of this cross-sectional register study was to examine possible associations between 9 pre-selected autoimmune diseases and psoriasis in children and adolescents. The study population consisted of all individuals living in Denmark, age under 18 years on 31 December 2012. Read More

    Abatacept reduces synovial regulatory T-cell expression in patients with psoriatic arthritis.
    Arthritis Res Ther 2017 Jul 5;19(1):158. Epub 2017 Jul 5.
    Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland.
    Background: The aim was to study changes in immunohistochemical expression markers of synovial and skin inflammation, clinical outcomes and magnetic resonance imaging (MRI) scores with abatacept treatment in patients with psoriatic arthritis (PsA).

    Methods: Biological-treatment-naïve PsA patients with active disease including synovitis of a knee were enrolled in this single-centre, crossover study. Patients were randomised to receive intravenous abatacept 3 mg/kg of body weight or placebo infusion on day 1, 15 and 29; thereafter abatacept 10 mg/kg of body weight was administered every 28 days for 5 months. Read More

    Incidence of Pulmonary Arterial Hypertension in Patients with Psoriasis: A Retrospective Cohort Study.
    Perm J 2017 ;21
    Director of Dermatology Research for the Department of Dermatology at the Los Angeles Medical Center in CA.
    Context: Inflammatory signaling may play an important role in the pathogenesis of pulmonary arterial hypertension (PAH).

    Objective: To assess the incidence of PAH in patients with mild and severe psoriasis compared with their respective controls.

    Design: From January 2004 to November 2012, we performed a retrospective cohort study of patients with psoriasis in the Kaiser Permanente Southern California Health Plan. Read More

    Dual energy CT iodine map for delineating inflammation of inflammatory arthritis.
    Eur Radiol 2017 Jul 3. Epub 2017 Jul 3.
    Department of Radiology, The Jikei University School of Medicine, 3-19-18, Nishi-shimbashi, Minato-ku, Tokyo, 1058471, Japan.
    Iodine mapping is an image-processing technique used with dual-energy computed tomography (DECT) to improve iodine contrast resolution. CT, because of its high spatial resolution and thin slice reconstruction, is well suited to the evaluation of the peripheral joints. Recent developments in the treatment of inflammatory arthritis that require early diagnosis and precise therapeutic assessment encourage radiological evaluation. Read More

    Psoriasis, Psoriatic Arthritis, and Thyroid Autoimmunity.
    Front Endocrinol (Lausanne) 2017 19;8:139. Epub 2017 Jun 19.
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Psoriasis (PsO) is a chronic relapsing/remitting autoimmune skin disease, associated with an increased risk of other autoimmune disorders. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis occurring approximately in 30% of PsO patients. Sporadic cases of association between PsO and autoimmune thyroid disorders (AITDs) have been reported. Read More

    Monocyte subpopulations study in patients with plaque psoriasis.
    Med Hypotheses 2017 Jul 29;104:101-103. Epub 2017 May 29.
    Immunology Service, Prof. Edgard Santos University Hospital, Federal University of Bahia, Brazil; Gonçalo Moniz Institute, Fiocruz, Salvador, BA, Brazil.
    Psoriasis is a chronic and systemic, immune-mediated, inflammatory disease, mainly manifested by skin and / or joints lesions, presenting with a wide degree of clinical severity, but generally with great impact on patients' quality of life. Despite advances in the understanding of its pathogenesis, especially regarding the participation of T-lymphocytes and the key role of TNF, the triggering factor of the disease at the molecular level remains unknown, as well as the function of other cell populations. By presenting antigens to T-lymphocytes, monocytes assume an important role in both innate and adaptive immune response. Read More

    Cardiovascular disease risk profiles in inflammatory joint disease entities.
    Arthritis Res Ther 2017 Jul 3;19(1):153. Epub 2017 Jul 3.
    Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, PO Box 23, Vinderen, N-0319, Oslo, Norway.
    Background: Patients with inflammatory joint diseases (IJD) have increased risk of cardiovascular disease (CVD). Our aim was to compare CVD risk profiles in patients with IJD, including rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) and evaluate the future risk of CVD.

    Methods: The prevalence and numbers of major CVD risk factors (CVD-RFs) (hypertension, elevated cholesterol, obesity, smoking, and diabetes mellitus) were estimated in patients with RA, axSpA and PsA. Read More

    Nail findings in patients with psoriatic arthritis: A cross-sectional study with special reference to transverse grooves.
    J Am Acad Dermatol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Dermatology, St. Luke's International University, Tokyo, Japan.
    Background: Patients with psoriatic arthritis (PsA) commonly present with nail manifestations; however, little is known about these manifestations.

    Objective: This study investigated whether nail findings can be used to discriminate between PsA and psoriasis without arthritis.

    Methods: We performed a retrospective analysis of 118 patients with PsA and 974 patients with psoriasis without arthritis who visited St. Read More

    Animal models of rheumatoid pain: experimental systems and insights.
    Arthritis Res Ther 2017 Jun 30;19(1):146. Epub 2017 Jun 30.
    Department of Biomedical Sciences, Cooper Medical School of Rowan University, 401 S. Broadway, Camden, NJ, 08103, USA.
    Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflammatory joint conditions such as rheumatoid arthritis, psoriatic arthritis and spondyloarthropathies. The functional links between peripheral inflammatory signals and the establishment of the neuroadaptive mechanisms acting in nociceptors and in the central nervous system in the establishment of chronic and neuropathic pain are still poorly understood, representing an area of intense study and translational priority. Read More

    [Psoriasis vs. psoriatic arthritis : Similarities and differences in the pathophysiology].
    Z Rheumatol 2017 Jun 29. Epub 2017 Jun 29.
    Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Deutschland.
    Psoriasis is a chronic inflammatory skin disease with genetic and (auto)immunological backgrounds. Up to 30% of patients with psoriasis also develop a mostly oligoarticular arthritis with spinal involvement that is termed psoriatic arthritis (PsA) and shows a specific joint pattern which differs from that of rheumatoid arthritis (RA). Both Psa and psoriasis share a common main axis, the interleukin (IL) 23/IL17 pathway as well as major overlaps in the functions of tumor necrosis factor alpha (TNFalpha). Read More

    [Differential diagnostic spectrum of psoriasis vs. psoriatic arthritis in skin and joints].
    Z Rheumatol 2017 Jun 29. Epub 2017 Jun 29.
    Sektion Rheumatologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland.
    Psoriasis and psoriatic arthritis are common disease entities in the daily routine of dermatologists and rheumatologists. The clinical management of the diseases profits tremendously from interdisciplinary contacts and shared decision-making processes. For dermatologists, recognition of early clinical symptoms of inflammatory arthropathies is pivotal. Read More

    [Psoriatic arthritis : Current therapeutic standards].
    Z Rheumatol 2017 Jun 29. Epub 2017 Jun 29.
    Abteilung Rheumatologie, Goethe-Universität Frankfurt/Main, Theodor-Stern-Kai 7, 60596, Frankfurt, Deutschland.
    Psoriatic arthritis (PsA) is a heterogeneous immune-mediated disease that usually involves the skin and joints but can also affect the entheses, spine and other extra-articular structures. Furthermore, it can be coupled with associated comorbidities. The selection of a patient-oriented and effective therapy is based on the extent of various manifestations of the disease as well as further influencing factors. Read More

    Matrix Metalloproteinases and Synovial Joint Pathology.
    Prog Mol Biol Transl Sci 2017 4;148:305-325. Epub 2017 May 4.
    Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, OH, United States. Electronic address:
    Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a critical role in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), and the spondyloarthropathies. MMP gene expression is upregulated in these synovial joint pathologies in response to elevated levels of proinflammatory cytokines and soluble mediators such as tumor necrosis factor-α, interleukin-1 (IL-1), IL-6, IL-17, and interferon-γ. Read More

    Risk of Tuberculosis Reactivation in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Receiving Non-Anti-TNF-Targeted Biologics.
    Mediators Inflamm 2017 1;2017:8909834. Epub 2017 Jun 1.
    Translational Research Unit, Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases "L. Spallanzani", Rome, Italy.
    Tuberculosis (TB) still represents an important issue for public health in underdeveloped countries, but the use of antitumor necrosis factor agents (anti-TNF) for the treatment of inflammatory rheumatic disorders has reopened the problem also in countries with low TB incidence, due to the increased risk of TB reactivation in subjects with latent tuberculosis infection (LTBI). Over the last 5 years, several non-anti-TNF-targeted biologics have been licensed for the treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. We reviewed the epidemiology of TB, the role of different cytokines and of the immune system cells involved in the immune response against TB infection, the methods to detect LTBI, and the risk of TB reactivation in patients exposed to non-anti-TNF-targeted biologics. Read More

    Calcipotriene betamethasone dipropionate aerosol foam in the treatment of plaque psoriasis: a review of the literature.
    Ther Deliv 2017 Jun 29. Epub 2017 Jun 29.
    Division of Dermatology, Baylor University Medical Center, 3900 Junius Street, Suite 125, Dallas, TX 75246, USA.
    Psoriasis is a common chronic immune-mediated skin disease which has a significant impact on patients' quality of life, and is associated with numerous comorbidities (i.e., psoriatic arthritis, Crohn's disease and cardiovascular disease). Read More

    Cardiovascular disease in immune-mediated inflammatory diseases: A cross-sectional analysis of 6 cohorts.
    Medicine (Baltimore) 2017 Jun;96(26):e7308
    aRheumatology Department and Instituto de Investigación Sanitaria San Carlos (IdISSC), Hospital Clínico San Carlos, Madrid bRheumatology Research Group, Vall d'Hebron Hospital Research Institute cDepartment of Medicine, University of Barcelona, Barcelona dGastroenterology Department, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid eCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) fGastroenterology and Hepatology Department, Hospital Universitari Germans Trias i Pujol, Badalona gUGC Reumatología, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga hRheumatology Department, Hospital Clinic and IDIBAPS iDermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona jUniversidad Autónoma de Barcelona, Barcelona kRheumatology Department, Hospital General Universitario de Guadalajara, Guadalajara lHospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Córdoba mHospital Clínic de Barcelona and IDIBAPS, Barcelona nDermatology Department oRheumatology Department, Complejo Hospitalario Universitario A Coruña, INIBIC, A Coruña pRheumatology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat qRheumatology Department, Hospital Universitario Doce de Octubre, Madrid, Spain.
    To analyze in several immune-mediated inflammatory diseases (IMIDs) the influence of demographic and clinical-related variables on the prevalence of cardiovascular disease (CVD), and compare their standardized prevalences.Cross-sectional study, including consecutive patients diagnosed with rheumatoid arthritis, psoriatic arthritis, psoriasis, systemic lupus erythematosus, Crohn disease, or ulcerative colitis, from rheumatology, gastroenterology, and dermatology tertiary care outpatient clinics located throughout Spain, between 2007 and 2010. Our main outcome was defined as previous diagnosis of angina, myocardial infarction, peripheral vascular disease, and/or stroke. Read More

    Clinical and serological characteristics of nail psoriasis in Indian patients: A cross-sectional study.
    Indian J Dermatol Venereol Leprol 2017 Jun 28. Epub 2017 Jun 28.
    Department of Microbiology, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India.
    Background: Nail involvement in psoriasis is common with a lifetime incidence of 80-90%. It may reflect severity of cutaneous involvement and predict joint disease. Yet it remains, poorly studied and evaluated especially in Indian psoriatic patients. Read More

    Brodalumab: the first anti-IL-17 receptor agent for psoriasis.
    Drugs Today (Barc) 2017 May;53(5):283-297
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Psoriasis is a chronic immune-mediated inflammatory skin disease in which the alteration of the interleukin-23 (IL-23)/IL-17 cytokine axis appears to be crucial from a pathogenetic perspective. This has been confirmed by the efficacy of monoclonal antibodies blocking IL-17A, such as secukinumab and ixekizumab. Brodalumab is a human anti-IL-17 receptor A (IL-17RA) monoclonal antibody that inhibits the biological activity of IL-17A, IL-17F and other IL-17 isoforms, and has been approved (210 mg s. Read More

    Ultrasound entheseal abnormalities at the distal interphalangeal joints and clinical nail involvement in patients with psoriasis and psoriatic arthritis, supporting the nail-enthesitis theory.
    Semin Arthritis Rheum 2017 May 11. Epub 2017 May 11.
    Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, University Institute Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Fundacion Dr. Pedro M. Catoggio para el Progreso de la Reumatología, Buenos Aires, Argentina. Electronic address:
    Objective: It has been shown that nail involvement in psoriasis is associated with systemic enthesopathy. Our objective was to evaluate the association of nail involvement and enthesopathy at distal interphalangeal joint (DIP) level in psoriasis (PsO) and psoriatic arthritis (PsA) patients.

    Methods: Consecutive patients (54 PsO and 56 PsA) seen at the outpatients clinic in this cross-sectional study were included. Read More

    Prevalence of immune-related systemic adverse events in patients treated with anti-Programmed cell Death 1/anti-Programmed cell Death-Ligand 1 agents: A single-centre pharmacovigilance database analysis.
    Eur J Cancer 2017 Jun 21;82:34-44. Epub 2017 Jun 21.
    Assistance Publique - Hôpitaux de Paris, Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique, F-94275 Le Kremlin-Bicêtre, France; INSERM, U1184, Immunology of Viral Infections and Autoimmune Diseases, F-94276 Le Kremlin-Bicêtre, France; Université Paris Sud, UMR 1184, F-94276 Le Kremlin-Bicêtre, France; CEA, DSV/iMETI, IDMIT, F-92265 Fontenay-aux-Roses, France. Electronic address:
    Aim: The growing use of immune checkpoint inhibitors (ICIs) is associated with the occurrence of immune-related adverse events (irAEs). Few data are published on systemic, immunohaematological and rheumatic irAEs. In a pharmacovigilance database analysis, we screened for these irAEs and calculated their prevalence. Read More

    Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review.
    Neurologist 2017 Jul;22(4):144-146
    *Department of Neurology, Faculty of Medicine, Ondokuz Mayis University †Medicana Samsun Hospital, Rheumatology, Canik, Samsun, Turkey.
    Multifocal motor neuropathy with conduction block (MMN-CB) is purely a motor neuropathy with progressive weakness that is characteristically caused by conduction blocks. Association with antiganglioside antibodies and a good response to immunomodulating therapies suggest an autoimmune etiology. In rare cases, MMN-CB has been reported as an adverse effect of infliximab, a tumor necrosis factor-α blocker. Read More

    Rheumatoid arthritis and psoriatic arthritis synovial fluid stimulates prolactin production by macrophages.
    J Leukoc Biol 2017 Jun 22. Epub 2017 Jun 22.
    Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    Prolactin (PRL) is a neuroendocrine hormone that can promote inflammation. We examined the synovial tissue and fluid levels of PRL in patients with inflammatory arthritis, PRL expression in differentiated Mϕs from patients with arthritis and from healthy donors, and the effects of different stimuli on PRL production by Mϕs. PRL levels were measured in paired synovial fluid (SF) and peripheral blood of patients with rheumatoid arthritis (RA, n = 19), psoriatic arthritis (PsA, n = 11), and gout (n = 11). Read More

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