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    1388 results match your criteria Psoriasis Pustular

    1 OF 28

    Efficacy of ixekizumab compared to etanercept and placebo in patients with moderate to severe plaque psoriasis and non-pustular palmoplantar involvement: results from three phase 3 trials (UNCOVER-1, -2, and -3).
    J Eur Acad Dermatol Venereol 2017 Mar 21. Epub 2017 Mar 21.
    Dermatologikum Hamburg and SCIderm GmbH, Hamburg, Germany.
    Background: Palmoplantar psoriasis has significant physical and emotional impact on patients and can be difficult to treat.

    Objective: To evaluate the efficacy of ixekizumab in the treatment of patients with moderate-to-severe non-pustular palmoplantar involvement and moderate-to-severe plaque psoriasis.

    Methods: In three phase 3, double-blind, placebo-controlled trials, patients with moderate-to-severe non-pustular plaque psoriasis (UNCOVER-1 (N=1296), UNCOVER-2 (N=1224), UNCOVER-3 (N=1346)) were randomised to subcutaneous 80 mg ixekizumab every 2 or 4 weeks (Q2W, Q4W), after a 160 mg starting dose, or placebo through week 12. Read More

    Successful Secukinumab treatment of generalized pustular psoriasis and erythrodermic psoriasis.
    J Eur Acad Dermatol Venereol 2017 Mar 20. Epub 2017 Mar 20.
    Section of Dermatology, AOU of Cagliari - Department of Medical Science and Public Health, University of Cagliari, Italy.
    Erythrodermic psoriasis (EP) and generalized pustular psoriasis (GPP) are the most severe forms of psoriasis, resulting in significant morbidity and even mortality (1) . There are few evidence-based data on their treatment (2,3) . Secukinumab, a fully human anti-IL-17A monoclonal antibody, demonstrated strong efficacy in treating moderate to severe plaque-type psoriasis (4,5) . Read More

    Autosomal dominant familial generalized pustular psoriasis caused by a CARD14 mutation.
    Br J Dermatol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Dermatology, Shinshu University, Graduate School of Medicine, Matsumoto, Japan.
    In 2012, gain-of-function mutations in CARD14, which encodes caspase recruitment domain family member 14, were identified as the cause of familial psoriasis vulgaris (PV) and familial pityriasis rubra pilaris (PRP).(1,2) We and another group reported that CARD14 variants are associated with generalized pustular psoriasis (GPP) and palmoplantar pustular psoriasis (PPP).(3-5) The other reports mentioned that CARD14 mutations in individuals with GPP and erythrodermic PRP. Read More

    Phenotypical analysis of ectoenzymes CD39/CD73 and adenosine receptor 2A in CD4(+) CD25(high) Foxp3(+) regulatory T-cells in psoriasis.
    Australas J Dermatol 2017 Mar 15. Epub 2017 Mar 15.
    Department of Dermatology, Huashan Hospital, Shanghai, China.
    Background: CD39 and CD73 are two novel cell surface markers of CD25(high) Foxp3(+) regulatory T-cells (Tregs). Concordant expression of these two ectoenzymes not only discriminate Tregs from other cell populations, but also generates pericellular adenosine, which has been reported to suppress proliferation of activated T effector (Teff) cells. Because it is currently unclear whether human ectoenzymes (CD39/CD73) are involved in the impaired suppressive activity of Tregs in psoriasis, we examined the frequencies and phenotypes of CD39/CD73-expressing Tregs and related receptor adenosine receptor 2A (A2A R) in peripheral blood of patients with different types of psoriasis. Read More

    [Clinical analysis of 82 cases of generalized pustular psoriasis].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Feb;42(2):173-178
    Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
    Objective: To analyze clinical features, laboratory tests, treatment and prognosis for patients with generalized pustular psoriasis (GPP).
 Methods: Clinical data of 82 patients with GPP (16 cases of children, 66 cases of adults) from the Department of Dermatology, Second Xiangya Hospital, Central South University were retrospectively analyzed.
 Results: Among the GPP patients, the male to female ratio was 1:1. Read More

    Could Psoriatic Arthritis Be Easily Diagnosed from Current Suspicious Physical Findings in the Dermatology Clinic?
    Ann Dermatol 2017 Feb 3;29(1):48-54. Epub 2017 Feb 3.
    Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
    Background: The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis are not well described in Asian populations, including Koreans.

    Objective: The purpose of this study was to investigate the prevalence of PsA by using the classification of psoriatic arthritis (CASPAR) criteria on the basis of physical examination only, as well as its correlation with psoriasis severity and other medical conditions including nail psoriasis.

    Methods: A single-center, cross-sectional observational cohort study was conducted, and the included patients were evaluated for PsA according to the CASPAR criteria. Read More

    Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA.
    J Autoimmun 2017 Feb 11. Epub 2017 Feb 11.
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:
    Background: IL36RN encodes the IL-36 receptor antagonist (IL-36Ra), and loss-of-function mutations in IL36RN define a recessively inherited autoinflammatory disease named "deficiency of IL-36Ra" (DITRA). DITRA causes systemic autoinflammatory diseases, including generalized pustular psoriasis (GPP), an occasionally life-threatening disease that is characterized by widespread sterile pustules on the skin, fever and other systemic symptoms. GPP can present at any age, and provocative factors include various infections, medicines and pregnancy. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Juvenile generalized pustular psoriasis is a chronic recalcitrant disease: an analysis of 27 patients seen in a tertiary hospital in Johor, Malaysia.
    Int J Dermatol 2017 Apr 14;56(4):392-399. Epub 2017 Feb 14.
    Department of Dermatology Hospital Sultanah Aminah, Johor Bahru, Malaysia.
    Background: Limited information exists regarding juvenile generalized pustular psoriasis (GPP). We aim to determine the clinical profile and outcome of Malaysians with juvenile GPP.

    Methods: Review of hospital case notes on patients with juvenile GPP. Read More

    Psoriasis in systemic lupus erythematosus: a single-center experience.
    Clin Rheumatol 2017 Apr 6;36(4):879-884. Epub 2017 Feb 6.
    Centre for Prognosis Studies in the Rheumatic Diseases Toronto Western Hospital, University of Toronto Lupus Clinic, University Health Network, 399 Bathurst St. 1E-410B, Toronto, ON, M5T 2S8, Canada.
    The coexistence of psoriasis with systemic lupus erythematosus (SLE) has been reported in limited case series, raising hypotheses about shared pathogenetic mechanisms. Nevertheless, important differences regarding treatment do exist. The aim of the present study was to determine the prevalence and characteristics of psoriasis in a defined cohort of lupus patients. Read More

    Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents.
    Dermatol Ther 2017 Jan 30. Epub 2017 Jan 30.
    Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
    Acrodermatitis continua of Hallopeau (ACH) is a variant of pustular psoriasis that is often very difficult to treat. Almost all anti-psoriatic agents have been used in the treatment of ACH. Ustekinumab, a fully human monoclonal antibody of the IgG1 class, is directed to the shared p40 subunit of cytokines IL-12 and IL-23. Read More

    Acute Generalized Erythrodermic Pustular Psoriasis Associated with Bupropion/Naltrexone (Contrave(®)).
    J Emerg Med 2017 Apr 24;52(4):e111-e113. Epub 2017 Jan 24.
    Department of Emergency Medicine, Erie County Medical Center, Buffalo, New York.
    Background: We report a case of erythrodermic pustular psoriasis associated with initiation of bupropion/naltrexone (Contrave®; Orexigen Therapeutics, La Jolla, CA) in a patient with no history of psoriasis.

    Case Report: A 55-year-old woman was transferred to our tertiary medical center from a community hospital for possible Stevens-Johnson syndrome 3 weeks after initiation of bupropion/naltrexone. The patient was admitted to the burn unit for wound treatment and hydration. Read More

    Bullous, pseudobullous, & pustular dermatoses.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:
    Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Read More

    Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes.
    J Dermatol Sci 2017 Mar 13;85(3):235-240. Epub 2016 Dec 13.
    Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:
    Background: IL36RN mutation has been identified as one pathogenesis of generalized pustular psoriasis, but the existence of GPP patients without mutation makes this controversial.

    Objective: Our study aimed at assessing the differences in clinical profiles of children with GPP, with and without IL36RN mutation.

    Methods: An ambispective case series study involved review of the records of 66 childhood patients with pediatric-onset GPP and without previous psoriasis vulgaris. Read More

    Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner.
    Mediators Inflamm 2016 12;2016:6756138. Epub 2016 Dec 12.
    Department of Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, 1158 MERB, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
    Generalized pustular psoriasis (GPP) is a severe form of psoriasis that can be caused by missense mutations in the interleukin-36 (IL-36) receptor antagonist. In addition to neutrophil rich skin inflammation, GPP patients typically also experience anorexia, fever, malaise, and pain. The imiquimod-induced skin inflammation mouse model has rapidly become a popular way to study plaque psoriasis, which typically does not involve symptoms of systemic disease. Read More

    IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis.
    J Allergy Clin Immunol 2016 Dec 31. Epub 2016 Dec 31.
    Department of Dermatology, University of Michigan, Ann Arbor, Mich.
    Background: Generalized pustular psoriasis (GPP) is a rare, debilitating, and often life-threatening inflammatory disease characterized by episodic infiltration of neutrophils into the skin, pustule development, and systemic inflammation, which can manifest in the presence or absence of chronic plaque psoriasis (PV). Current treatments are unsatisfactory and warrant a better understanding of GPP pathogenesis.

    Objective: We sought to understand better the disease mechanism of GPP to allow improved targeted therapies. Read More

    Annular pustular psoriasis in a 14-month-old girl: a therapeutic challenge.
    J Dermatolog Treat 2017 Jan 6:1-6. Epub 2017 Jan 6.
    a Department of Dermatology, Venereology and Allergology , University Hospital Würzburg , Würzburg , Germany.
    Annular pustular psoriasis (annular PP) is a rare but severe variant of psoriasis, which may even occur in early childhood. At this age, therapeutic options are limited and medication issues can be challenging. We report clinical features, diagnostic findings and treatment of an 11-month-old girl with annular PP. Read More

    Psoriasis: Epidemiology, clinical features, co-morbidities, and clinical scoring.
    Indian Dermatol Online J 2016 Nov-Dec;7(6):471-480
    Department of Dermatology, Venereology and Leprology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
    On the basis of current evidence derived from hospital-based studies, mostly from North India, the prevalence of psoriasis in adults varies from 0.44 to 2.8%, with a much lower prevalence in children. Read More

    Palmoplantar psoriasis.
    Clin Dermatol 2017 Jan - Feb;35(1):19-27. Epub 2016 Sep 10.
    Department of Dermatology, Cerrahpaşa Medical Faculty, İstanbul University, Fatih, İstanbul, Turkey.
    Palmoplantar psoriasis refers to a localized psoriasis variant. The disease can be associated with many clinical forms, including predominantly pustular lesions to thick scaly, hyperkeratotic plaques, or an overlapping of both of them. Palmoplantar psoriasis accounts for 3-4% of all psoriasis cases in most studies. Read More

    Generalized Pustular Psoriasis (Von Zumbusch Type) Following Renal Transplant: A Case Report.
    Exp Clin Transplant 2016 Dec 2. Epub 2016 Dec 2.
    From the First Department of Surgery, Transplant Unit, "Evangelismos" General Hospital of Athens, Greece.
    Generalized pustular psoriasis appears as an uncommon variant form of psoriasis consisting of widespread pustules on an erythematous background (von Zumbusch). A 39-year-old male patient with a history of plaque psoriasis since the age of 9 who had an acute relapse of generalized pustular psoriasis 12 days following a successful renal transplantation is presented. Despite administered immunosuppression for transplantation, the addition of cyclosporine and methotrexate did not reverse the ongoing process of disease and the patient died on the 57th posttransplant day due to multiorgan failure subsequent to severe bone marrow suppression. Read More

    Mutations in IL36RN are associated with geographic tongue.
    Hum Genet 2017 Feb 29;136(2):241-252. Epub 2016 Nov 29.
    Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
    Geographic tongue (GT) is a benign inflammatory disorder of unknown etiology. Epidemiology and histopathology in previous studies found that generalized pustular psoriasis (GPP) is a factor associated with GT, but the molecular mechanism remains obscure. To investigate the mechanism of GT, with and without GPP, three cohorts were recruited to conduct genotyping of IL36RN, which is the causative gene of GPP. Read More

    Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders.
    J Allergy Clin Immunol 2016 Nov 21. Epub 2016 Nov 21.
    Department of Dermatology, University of Michigan, Ann Arbor, Mich. Electronic address:
    Background: Pustular skin disorders are a category of difficult-to-treat and potentially life-threatening conditions that involve the appearance of neutrophil-rich pustules. The molecular basis of most pustular skin conditions has remained unknown.

    Objective: We sought to investigate the molecular basis of 3 pustular skin disorders: generalized pustular psoriasis (GPP), palmoplantar pustulosis (PPP), and acute generalized exanthematous pustulosis (AGEP). Read More

    Efficacy and safety of dose escalation of infliximab therapy in Japanese patients with psoriasis: Results of the SPREAD study.
    J Dermatol 2016 Nov 24. Epub 2016 Nov 24.
    Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
    Although infliximab is approved for psoriasis, its efficacy is reduced over time in some patients. The aim of this phase III trial is to evaluate efficacy and safety of infliximab dose escalation in Japanese psoriasis patients with loss of efficacy to standard-dose therapy. Patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis or psoriatic erythroderma who showed loss of efficacy to standard-dose therapy received infliximab dose escalation (10 mg/kg every 8 weeks) from weeks 0 to 32. Read More

    Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?
    Postepy Dermatol Alergol 2016 Oct 21;33(5):336-339. Epub 2016 Oct 21.
    Department of Dermatology, Medical University of Lodz, Lodz, Poland.
    Introduction: Pustular palmoplantar psoriasis (PPP) is a rare type of psoriasis affecting mainly distal parts of the limbs. Despite numerous theories about etiology of PPP, the pathogenesis still remains unclear. Recent data indicate that interleukin (IL)-15, IL-17 and IL-22 enhance a proinflammatory response in certain skin inflammatory diseases such as psoriasis and atopic dermatitis. Read More

    Ustekinumab in the treatment of palmoplantar pustular psoriasis - a case series of nine patients.
    J Dtsch Dermatol Ges 2016 Nov;14(11):1108-1113
    Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Background: Palmoplantar pustular psoriasis is a chronic inflammatory skin disease that is associated with considerable impairment in quality of life and resilience. Given the lack of approved pharmacological agents for this indication and the frequently recalcitrant disease course, therapeutic options are limited.

    Patients And Methods: Following unsatisfactory therapeutic attempts with other treatment modalities, nine patients (six women; three men) were treated with ustekinumab (45 mg in individuals < 100 kg body weight, 90 mg in individuals > 100 kg) at weeks 0, 4, 12, and 24. Read More

    Generalized pustular psoriasis induced by systemic steroid dose reduction.
    An Bras Dermatol 2016 Sep-Oct;91(5):664-666
    Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.
    Generalized pustular psoriasis, or psoriasis of von Zumbusch, is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this work, we report the case of a female patient, 70 years old, who developed generalized pustular psoriasis symptoms while reducing the dose of oral corticosteroids, improperly introduced for the treatment of alleged acute generalized exanthematous pustulosis. The differential diagnosis of generalized pustular psoriasis should be made with other pustular dermatoses, such as subcorneal pustulosis, IgA pemphigus and especially with acute generalized exanthematous pustulosis. Read More

    Recurrent Streptococcus agalactiae Toxic Shock Syndrome Triggered by a Tumor Necrosis Factor-α Inhibitor.
    Intern Med 2016;55(21):3211-3214. Epub 2016 Nov 1.
    The Second Department of Internal Medicine, Nagasaki University Hospital, Japan.
    Streptococcal toxic shock syndrome caused by group B streptococcus (GBS) is a rare, but lethal disease. We experienced a 45-year-old woman with pustular psoriasis who developed toxic shock-like syndrome during infliximab treatment. Surprisingly, similar episodes recurred three times in one year with restarting of infliximab treatments. Read More

    [Acute generalized exanthematous pustulosis induced by piroxicam].
    Rev Alerg Mex 2016 Oct-Dec;63(4):408-412
    Clínica El Rosario Sede Tesoro. Medellín, Antioquia, Colombia.
    Background: Between 62 and 90% of cases of acute generalized exanthematous pustulosis are caused by drugs. Its onset is rapid with generalized pustules, fever, and blood neutrophil count over 7000; pustules resolve spontaneously in less than 15 days. A case associated with piroxicam described. Read More

    The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases.
    Ann N Y Acad Sci 2016 Oct 26. Epub 2016 Oct 26.
    National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland.
    The recently discovered interleukin (IL)-36 family of cytokines form part of the broader IL-1 family and are emerging as important mediators of inflammatory disease. The IL-36 subfamily consists of three ligands-IL-36α, IL-36β, and IL-36γ-and the natural antagonist IL-36Ra. The cytokines exert their effects through a specific IL-36 receptor consisting of IL-36R and IL-1RAcP chains. Read More

    Systemic cyclosporine treatment in severe childhood psoriasis: A retrospective chart review.
    J Dermatolog Treat 2017 Feb 24;28(1):18-20. Epub 2016 Oct 24.
    a Department of Dermatology , Venereology, and Leprology, Postgraduate Institute of Medical Education and Research , Chandigarh , India.
    Background: Data regarding the use of cyclosporine (CYC) in the treatment of childhood psoriasis is meager.

    Materials And Methods: The records of all psoriasis patients aged less than 18 years and treated with systemic CYC at our institute were retrieved. Clinical status of patients was assessed at regular intervals and response to therapy was graded as good (50-75% decrease in PASI) and excellent (>75% decrease). Read More

    AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production.
    J Invest Dermatol 2016 Nov 5;136(11):2251-2259. Epub 2016 Jul 5.
    Division of Genetics and Molecular Medicine, King's College London, London, UK. Electronic address:
    Prominent skin involvement is a defining characteristic of autoinflammatory disorders caused by abnormal IL-1 signaling. However, the pathways and cell types that drive cutaneous autoinflammatory features remain poorly understood. We sought to address this issue by investigating the pathogenesis of pustular psoriasis, a model of autoinflammatory disorders with predominant cutaneous manifestations. Read More

    Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study.
    Br J Dermatol 2017 Mar 2;176(3):741-751. Epub 2016 Oct 2.
    Kyowa Hakko Kirin Co. Ltd, Tokyo, Japan.
    Background: A T-helper (Th) cell subset Th17 preferentially produces interleukin (IL)-17 and plays a pivotal role in the pathogenesis of psoriasis. However, the pathological roles of IL-17 cascades in generalized pustular psoriasis (GPP) and psoriatic erythroderma (PsE) have not been well established.

    Objectives: To evaluate the efficacy and safety of brodalumab, a human immunoglobulin G2 monoclonal antibody against human IL-17-receptor A (IL-17RA), in Japanese patients with GPP and PsE. Read More

    Prevalence of psoriatic arthritis and its correlates among patients with psoriasis in Greece: results from a large retrospective study.
    J Eur Acad Dermatol Venereol 2016 Oct 10;30(10):1749-1752. Epub 2016 Aug 10.
    2nd Department of Dermatology and Venereology, University of Athens, Attikon General Hospital, Chaidari, Greece.
    Objectives: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital.

    Methods: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013.

    Results: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Read More

    Liver test abnormalities in patients admitted for severe psoriasis: prevalence and associated risk factors.
    J Eur Acad Dermatol Venereol 2016 Oct 26;30(10):1742-1748. Epub 2016 May 26.
    Inserm, Centre d'Investigation Clinique 1430, Créteil, France.
    Background: Few epidemiologic data are available regarding biologic liver abnormalities during psoriasis flares.

    Objectives: The aim of this study was to assess the prevalence of biological liver test abnormalities (LTA) in a psoriasis population and the risk factors associated with LTA.

    Methods: A retrospective cross-sectional study in four hospital dermatology tertiary care centres included patients admitted for severe psoriasis flare between 1st January 2010 and 31st December 2011. Read More

    Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway.
    J Dermatol Sci 2017 Jan 29;85(1):20-26. Epub 2016 Sep 29.
    Laboratory of Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065 USA.
    Background: Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis, which has significant negative impact on quality of life. The cellular and molecular inflammatory pathways involved in PPPP have not been well studied.

    Objective: Study the expression of cytokines and chemokines involved in the IL-17/IL-23 axis in palmoplantar pustular psoriasis and other difficult to treat psoriasis areas (palms, scalp, elbows and lower legs). Read More

    Adalimumab administration after infliximab therapy is a successful treatment strategy for generalized pustular psoriasis.
    J Dermatol 2016 Oct 15. Epub 2016 Oct 15.
    Department of Dermatology, Jichi Medical University, Shimotsuke, Japan.
    We report a case of a 70-year-old woman with generalized pustular psoriasis (GPP) who responded well to infliximab therapy and adalimumab therapy after secondary failure of infliximab therapy, but did not respond to ustekinumab therapy. We speculate that the pathogenic factor in this case favored anti-tumor necrosis factor (TNF)-α therapy to anti-interleukin-12/23 therapy. Herein, we also briefly present three additional cases of treatment with adalimumab after secondary failure of infliximab. Read More

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