1,691 results match your criteria Psoriasis Pustular


Biologics in the treatment of pustular psoriasis.

Expert Opin Drug Saf 2020 Jul 2:1-11. Epub 2020 Jul 2.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China.

Introduction: Pustular psoriasis is a group of skin diseases characterized by neutrophil infiltration in the epidermis and formation of sterile pustules. Conventional treatments, such as retinoids and immunosuppressive drugs, have improved the clinical manifestations; however, many patients suffer from drug-related toxicity or are resistant to therapy.

Areas Covered: In this review, the authors focus on the efficacy and safety of these biologics, including anti-IL-1β (gevokizumab and canakinumab), anti-IL-1 R (anakinra), anti-IL-36 R (BI 655130), anti-tumor necrosis factor-α (etanercept, infliximab, and adalimumab), anti-IL-12/23 (ustekinumab), anti-IL-17A (secukinumab and ixekizumab), anti-IL-17RA (brodalumab), anti-IL-2 R (basiliximab), anti-IL-6 R (tocilizumab), and anti-IL-23 (risankizumab and guselkumab), for treating pustular psoriasis. Read More

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http://dx.doi.org/10.1080/14740338.2020.1785427DOI Listing

Increased level of high mobility group box 1 in the serum and skin in patients with generalized pustular psoriasis.

J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

High-mobility group box 1 (HMGB-1) is a highly abundant pro-inflammatory protein associated with the pathogenesis of inflammatory and autoimmune diseases. HMGB-1 expression level increases in patients with psoriasis vulgaris (PV). However, HMGB-1 expression in patients with generalized pustular psoriasis (GPP) is unknown. Read More

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http://dx.doi.org/10.1111/1346-8138.15467DOI Listing

Clinical characteristics, genetics, comorbidities and treatment of palmoplantar pustulosis: A retrospective analysis of 66 cases in a single center in Taiwan.

J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

We retrospectively analyzed 66 patients with palmoplantar pustulosis (PPP) from January 1994 to September 2019 in our department. Interleukin-36 receptor antagonist gene (IL36RN) intron 3 c.115+6T>C mutation was present in two out of 27 patients (7. Read More

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http://dx.doi.org/10.1111/1346-8138.15470DOI Listing

CARD14 signalling in keratinocytes induces TNF-dependent skin and systemic inflammation.

Elife 2020 Jun 29;9. Epub 2020 Jun 29.

Immunology & Inflammation, Imperial College London, London, United Kingdom.

To investigate how the psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous mutation from the endogenous mouse locus. Heterozygous expression of CARD14 rapidly induced skin acanthosis, immune cell infiltration and expression of psoriasis-associated pro-inflammatory genes. Homozygous expression of CARD14 induced more extensive skin inflammation and a severe systemic disease involving infiltration of myeloid cells in multiple organs, temperature reduction, weight loss and organ failure. Read More

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http://dx.doi.org/10.7554/eLife.56720DOI Listing

Infant case of generalized pustular psoriasis preceded by interstitial lung disease.

J Dermatol 2020 Jun 28. Epub 2020 Jun 28.

Departments of, Department of, Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

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http://dx.doi.org/10.1111/1346-8138.15465DOI Listing

Higher prevalence of thyroid dysfunction in patients with erythrodermic psoriasis.

J Dermatol 2020 Jun 22. Epub 2020 Jun 22.

Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

The association of psoriasis with thyroid dysfunction has been investigated. However, it remains unclear; some papers indicate it, and others do not. In this study, we evaluate the prevalence of thyroid dysfunction in patients with psoriasis vulgaris (PsV), psoriatic arthritis (PsA), generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP), and the association of thyroid dysfunction with inflammation. Read More

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http://dx.doi.org/10.1111/1346-8138.15427DOI Listing

IL-36 in chronic inflammation and cancer.

Authors:
Markus F Neurath

Cytokine Growth Factor Rev 2020 Jun 7. Epub 2020 Jun 7.

Medical Clinic 1, Department of Medicine, University Hospital Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Ulmenweg 18, 91054 Germany. Electronic address:

IL-36 belongs to the IL-1 family of cytokines and activates target cells by binding to a specific cytokine receptor (IL-36R) followed by activation of intracellular regulators such as MAP kinases and NF-kappaB. Three subforms of IL-36, denoted IL-36alpha, IL-36beta and IL-36gamma, have been described that require N-terminal cleavage for activation. Functional studies have shown that IL-36 may activate a broad spectrum of immune and non-immune cells such as macrophages, T cells, keratinocytes and epithelial cells in an IL-1-independent fashion and thereby controls various inflammatory or oncogenic processes in the skin, the lung, the kidney, the liver and the intestine, respectively. Read More

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http://dx.doi.org/10.1016/j.cytogfr.2020.06.006DOI Listing

Generalized pustular psoriasis-like drug eruption manifested by systemic glucocorticosteroid in a patient without IL36RN mutation or an immunological disorder.

Eur J Dermatol 2020 Apr;30(2):183-184

Department of Dermatology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5503, Japan.

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http://dx.doi.org/10.1684/ejd.2020.3719DOI Listing

Secukinumab retreatment associated psoriasis flare with pustules.

J Dermatolog Treat 2020 Jun 19:1-4. Epub 2020 Jun 19.

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

This case report describes a patient with plaque psoriasis and psoriatic arthritis who experienced IL-17A blocking antibody secukinumab treatment-interruption followed by re-treatment. The patient showed heterogeneous responses; significant improvement at initial introduction of secukinumab with rapid deterioration after discontinuation, followed by worsening symptoms and pustular eruption with reintroduction, and skin clearance after dose escalation. Read More

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http://dx.doi.org/10.1080/09546634.2020.1782816DOI Listing

Pustular allergic contact dermatitis caused by sunscreen.

Contact Dermatitis 2020 Jun 8. Epub 2020 Jun 8.

Department of Dermato-venereology, Aarhus University Hospital, Denmark.

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http://dx.doi.org/10.1111/cod.13621DOI Listing

Successful therapy of palmoplantar pustulosis with tofacitinib - report on three cases.

Dermatol Ther 2020 Jun 3:e13753. Epub 2020 Jun 3.

Department of Dermatology and Allergology, University Hospital Bonn, Germany.

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http://dx.doi.org/10.1111/dth.13753DOI Listing

Combination therapy with biologic and colchicine for generalized pustular psoriasis.

Int J Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, Saitama Medical University, Saitama Medical Center, Saitama, Japan.

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http://dx.doi.org/10.1111/ijd.14959DOI Listing

Paradoxical Skin Reaction to Certolizumab, an Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis: Case Report with Literature Review.

Dermatol Ther (Heidelb) 2020 May 23. Epub 2020 May 23.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wrocław, Poland.

Introduction: Biologic agents form an indispensable part of modern therapeutic regimens for the treatment of severe inflammatory diseases, especially in the fields of rheumatology, dermatology and gastroenterology. They are favoured by both physicians and patients due to their high effectiveness, good patient tolerance and safety. However, interference in the regulation and dynamics of inflammatory cytokines can on occasion lead to an onset of a dermatological condition also known as paradoxical skin reaction. Read More

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http://dx.doi.org/10.1007/s13555-020-00398-4DOI Listing

A case of drug-induced bullous pemphigoid associated with teriflunomide: A patient with relapsing multiple sclerosis.

Mult Scler Relat Disord 2020 May 15;43:102157. Epub 2020 May 15.

Hacettepe University, Department of Neurology, Hacettepe, 06230, Ankara, Turkey.

Background: There aren't many reported skin changes associated with teriflunomide use in patients with multiple sclerosis (MS) mm Only one life-threatening gross skin change has been reported so far; a patient with toxic epidermal necrolysis. There are also a few case reports about cutaneous adverse effects of teriflunomide, such as eczema, rash and palmar pustular psoriasis.

Methods: We herein report the first case of bullous drug reaction in a patient receiving teriflunomide treatment. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102157DOI Listing

Local reinfusion of B10 cells is effective in the treatment of pustular psoriasis.

Dermatol Ther 2020 May 22:e13645. Epub 2020 May 22.

Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Psoriasis is a common chronic skin disease characterized by epidermal proliferation and inflammation. Pustular psoriasis (PP) is one of the most serious and refractory. The number, differentiation, and function of B10 cells in patients with PP were analyzed, and the relationship between B10 cells and PP, an autoimmune disease, was explored. Read More

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http://dx.doi.org/10.1111/dth.13645DOI Listing

Recurrent generalized pustular psoriasis possibly triggered by apremilast.

Chin Med J (Engl) 2020 May;133(10):1259-1260

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

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http://dx.doi.org/10.1097/CM9.0000000000000795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249705PMC

Infliximab for the treatment of recalcitrant generalized pustular psoriasis of pregnancy: Report of a challenging case.

Dermatol Ther 2020 May 13:e13571. Epub 2020 May 13.

Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Pustular psoriasis of pregnancy (PPP), also known as impetigo herpetiformis, is a rare gestational dermatosis that may induce life-threatening complications for both the mother and fetus. Treatment of recalcitrant generalized PPP may be challenging as available therapeutic options are limited. We herein present a 24-year-old pregnant woman with generalized PPP accompanied by high fever, fatigue, leukocytosis, and elevated levels of serum acute phase reactants. Read More

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http://dx.doi.org/10.1111/dth.13571DOI Listing

Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups.

BMC Med Genet 2020 May 12;21(1):102. Epub 2020 May 12.

Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 10, 91054, Erlangen, Germany.

Background: Syndrome of synovitis acne pustulosis hyperostosis osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) present two diseases of a dermatologic and rheumatologic spectrum that are variable in manifestation und therapeutic response. Genetic risk factors have long been assumed in both diseases, but no single reliable factor has been identified yet. Therefore, we aimed to clinically characterize a patient group with syndrome of synovitis acne pustulosis hyperostosis osteitis (SAPHO) (n = 47) and chronic recurrent multifocal osteomyelitis (CRMO)/ chronic non-bacterial osteomyelitis (CNO) (n = 9) and analyze a CRMO candidate gene. Read More

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http://dx.doi.org/10.1186/s12881-020-01037-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216525PMC

Generalized pustular psoriasis in pregnancy, successfully treated with certolizumab pegol.

J Dermatol 2020 Jul 4;47(7):e262-e263. Epub 2020 May 4.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

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http://dx.doi.org/10.1111/1346-8138.15355DOI Listing

[Neutrophilic and pustular dermatoses : New autoinflammatory diseases and syndromes].

Pathologe 2020 Jul;41(4):364-370

Dermatohistologie, Hautklinik, Universitätsklinikum Münster, Münster, Deutschland.

This article reviews noninfectious inflammatory dermatoses with mainly neutrophilic infiltrates and the formation of pustules. The infiltrate containing neutrophils may either be mild as in urticaria or very dense, even with leukocytoclasia, as in Sweet syndrome or pyoderma gangrenosum. Neutrophilic infiltrates and pustular eruptions are caused by different noninfectious immunomechanisms. Read More

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http://dx.doi.org/10.1007/s00292-020-00784-xDOI Listing

Pustular psoriasis with severe liver dysfunction: psoriasis-specific immune hepatitis?

Eur J Dermatol 2020 Apr 16. Epub 2020 Apr 16.

Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.

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http://dx.doi.org/10.1684/ejd.2020.3720DOI Listing

Novel use of Autoinflammatory Diseases Activity Index (AIDAI) captures skin and extracutaneous features to help manage pediatric DITRA: A case report and a proposal for a modified disease activity index in autoinflammatory keratinization disorders.

Pediatr Dermatol 2020 Apr 17. Epub 2020 Apr 17.

Department of Paediatrics, University of Calgary, Calgary, AB, Canada.

Generalized pustular psoriasis (GPP) is a severe form of psoriasis, which is rare in pediatric and adult patients. It is characterized by sterile pustular lesions that appear on erythematous skin, associated with systemic features. A recent identification of mutations in the IL36RN gene in some GPP patients has led to a diagnosis of new autoinflammatory disease, interleukin-36-receptor antagonist deficiency (DITRA). Read More

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http://dx.doi.org/10.1111/pde.14155DOI Listing

Designation of Autoinflammatory Skin Manifestations With Specific Genetic Backgrounds.

Authors:
Nobuo Kanazawa

Front Immunol 2020 18;11:475. Epub 2020 Mar 18.

Department of Dermatology, Wakayama Medical University, Wakayama, Japan.

"Autoinflammatory disease (AiD)" has first been introduced in 1999 when the responsible gene for the familial Hibernean fever or autosomal dominant-type familial Mediterranean fever-like periodic fever syndrome was reportedly identified as . Linked with the rapid research progress in the field of innate immunity, "autoinflammation" has been designated for dysregulated innate immunity in contrast to "autoimmunity" with dysregulated acquired immunity. As hereditary periodic fever syndromes represent the prototype of AiD, monogenic systemic diseases are the main members of AiD. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093487PMC

Successful treatment of juvenile generalized pustular psoriasis with infliximab therapy: two case reports.

J Int Med Res 2020 03;48(3):300060520912091

Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.

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http://dx.doi.org/10.1177/0300060520912091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132563PMC

Spesolimab: A Novel Treatment for Pustular Psoriasis.

J Cutan Med Surg 2020 Mar/Apr;24(2):199-200

54473 507266 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475419888862DOI Listing

Palmoplantar pustulosis: Current understanding of disease definition and pathomechanism.

J Dermatol Sci 2020 Apr 14;98(1):13-19. Epub 2020 Mar 14.

Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan. Electronic address:

Pustulosis palmaris et plantaris, or palmoplantar pustulosis (PPP), is a chronic pustular dermatitis involving the palms and soles and is characterized by vesicles, pustules, erythema, lichenification, and abnormal desquamation. It is one of the most common skin diseases in Japan but its pathomechanism is unclear and the disease remains poorly defined. Consequently, adequate treatment for PPP is lacking. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.03.003DOI Listing

Dermatoscopy in life-threatening and severe acute rashes.

Clin Dermatol 2020 Jan - Feb;38(1):113-121. Epub 2019 Nov 11.

Institute of Dermatology, Santa Maria della Misericordia University Hospital, Udine, Italy.

A prompt recognition of life-threatening and severe acute rashes is of utmost importance to start an appropriate therapy as soon as possible. Consequently, clinicians often must rely only on clinical data to make a diagnosis because some diagnostic procedures may take a relatively long time to be performed (eg, histologic examination, microbiologic tests). In this scenario, dermatoscopy may be useful as an auxiliary tool to support the diagnosis by highlighting subclinical features. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.013DOI Listing
November 2019

Combination therapy with acitretin and glycyrrhizin in generalized pustular psoriasis with liver test abnormalities: A case series.

Dermatol Ther 2020 May 31;33(3):e13318. Epub 2020 Mar 31.

Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.

Liver test abnormalities (LTA) are a frequent extracutaneous manifestation in generalized pustular psoriasis (GPP). Due to possible hepatotoxicity of systemic monotherapy, it is challenging to simultaneously achieve clinical remission and LTA normalization. However, evidence for therapy is lacking. Read More

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http://dx.doi.org/10.1111/dth.13318DOI Listing

Efficacy of guselkumab in a subpopulation with pustulotic arthro-osteitis through week 52: an exploratory analysis of a phase 3, randomized, double-blind, placebo-controlled study in Japanese patients with palmoplantar pustulosis.

J Eur Acad Dermatol Venereol 2020 Mar 16. Epub 2020 Mar 16.

Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan.

Background: Previous studies of guselkumab have demonstrated clinical benefits in patients with plaque-type psoriasis, generalized pustular psoriasis, erythrodermic psoriasis and palmoplantar pustulosis (PPP).

Objective: The aim of this exploratory analysis of a double-blind, multicenter, placebo-controlled, phase 3 study in Japanese patients with PPP was to evaluate the efficacy of guselkumab in the subset of patients with pustulotic arthro-osteitis (PAO).

Methods: Patients were randomized to receive guselkumab 100 or 200 mg at weeks 0, 4, 12 and every 8 weeks, or placebo with cross-over to guselkumab 100 or 200 mg at week 16 (placebo group). Read More

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http://dx.doi.org/10.1111/jdv.16355DOI Listing

Clinical and histopathologic features differentiating acute generalized exanthematous pustulosis and pustular psoriasis: A retrospective series.

J Am Acad Dermatol 2020 Jul 12;83(1):265-267. Epub 2020 Mar 12.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.03.015DOI Listing

Prognostic Factors and Long-Term Efficacy of Tonsillectomy in 17 Patients with Pustulotic Arthro-Osteitis.

Eurasian J Med 2020 Feb;52(1):103-105

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

In this case study, we aimed to evaluate the disease condition of patients with pustulotic arthro-osteitis (PAO) at 36-month post-tonsillectomy. A retrospective analysis of the cases of 17 patients with PAO who were resistant to initial systemic treatments and underwent tonsillectomy at our hospital in 2006-2016 was conducted. The patients' disease condition at 1-, 24-, and 36-month post-tonsillectomy was assessed by the visual analog scale (VAS) score for osteoarthropathic pain, the disease duration, the area of palmoplantar lesions, and the Palmoplantar Pustular Psoriasis Area Severity Index (ppPASI). Read More

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http://dx.doi.org/10.5152/eurasianjmed.2019.19099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051221PMC
February 2020

Autoinflammatory Keratinization Diseases (AiKDs): Expansion of Disorders to Be Included.

Authors:
Masashi Akiyama

Front Immunol 2020 21;11:280. Epub 2020 Feb 21.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.3389/fimmu.2020.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046805PMC
February 2020

Childhood generalized pustular psoriasis: Successful long-term treatment with adalimumab.

Dermatol Ther 2020 May 13;33(3):e13294. Epub 2020 Mar 13.

Dermatology Section, Department of Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1111/dth.13294DOI Listing

Dyshidrotic eczema in two patients on secukinumab for plaque psoriasis: A case report.

SAGE Open Med Case Rep 2020 10;8:2050313X20904561. Epub 2020 Feb 10.

Division of Dermatology, The Ottawa Hospital, Ottawa, ON, Canada.

Secukinumab was the first fully human anti-interleukin-17a monoclonal antibody and successfully treated moderate-severe psoriasis. These new, targeted, medications are becoming more ubiquitous, but long-term side effects are not fully known. Post-market surveillance is crucial to identify delayed adverse events, analogous to the paradoxical development of pustular psoriasis in a subset of patients treated with the anti-tumor necrosis factor-alpha class drugs. Read More

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http://dx.doi.org/10.1177/2050313X20904561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011358PMC
February 2020

The expanding pathways of autoinflammation: a lesson from the first 100 genes related to autoinflammatory manifestations.

Adv Protein Chem Struct Biol 2020 12;120:1-44. Epub 2019 Dec 12.

Autoinflammatory Diseases and Immunodeficiencies Centre, IRCCS Istituto Giannina Gaslini, Genova, GE, Italy.

AutoInflammatory Diseases (AIDs) are a group of innate immune system disorders characterized by sterile inflammation without evidence of pathogenic autoantibodies or auto-reactive T lymphocytes. An expanding spectrum of genes and molecular pathways are associated with AIDs. Inflammasomopathies are secondary to dysregulation of multi-protein complexes, called inflammasomes, leading to an excessive maturation and secretion of IL1β and IL18. Read More

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http://dx.doi.org/10.1016/bs.apcsb.2019.11.001DOI Listing
December 2019

Mold mite infestation in toenail dermatophytoma with pustular psoriasis.

J Dtsch Dermatol Ges 2020 Mar 20;18(3):251-252. Epub 2020 Feb 20.

Department of Pathology, Teikyo University Chiba Medical Center, Anesaki, Ichihara, Chiba, Japan.

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http://dx.doi.org/10.1111/ddg.14040DOI Listing

The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review.

Expert Rev Clin Immunol 2020 Mar 19;16(3):239-252. Epub 2020 Feb 19.

Therapeutic Area Immunology & CNS, Boehringer Ingelheim International GmbH, Rheinland-Pfalz, Germany.

: Generalized pustular psoriasis (GPP) is characterized by widespread erythema and edema, superficial sterile coalescing pustules, and lakes of pus. Although the impact of GPP is thought to be substantial, emerging literature on its clinical, humanistic, and economic burden has not previously been described in a structured way.: A structured search focused on the identification of studies in GPP using specific search terms in PubMed and EMBASE® from 2005 onwards, with additional back-referencing and pragmatic searches. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1708193DOI Listing

[Acute pancreatitis under acitretin].

Ann Dermatol Venereol 2020 Feb 11. Epub 2020 Feb 11.

Service de dermatologie, CHU Ibn Rochd, université Hassan II, Casablanca, Maroc.

Introduction: Retinoids are vitamin A derivatives with numerous indications in dermatology. Acute pancreatitis is a rare adverse effect of systemic retinoids. We report a case occurring during acitretin treatment for psoriasis. Read More

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http://dx.doi.org/10.1016/j.annder.2020.01.015DOI Listing
February 2020

Unusual hair loss pattern in Graham-Little syndrome coexistent with palmoplantar pustular psoriasis.

J Dermatol 2020 Apr 13;47(4):e116-e117. Epub 2020 Feb 13.

Department of Dermatology, Ruhr University, Bochum, Germany.

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http://dx.doi.org/10.1111/1346-8138.15265DOI Listing

A randomised placebo controlled trial of anakinra for treating pustular psoriasis: statistical analysis plan for stage two of the APRICOT trial.

Trials 2020 Feb 10;21(1):158. Epub 2020 Feb 10.

Imperial Clinical Trials Unit, Imperial College London, W12 7RH, London, UK.

Background: Current treatment options for Palmoplantar Pustulosis (PPP), a debilitating chronic skin disease which affects the hands and feet, are limited. The Anakinra for Pustular psoriasis: Response in a Controlled Trial (APRICOT) aims to determine the efficacy of anakinra in the treatment of PPP. This article describes the statistical analysis plan for the final analysis of this two-staged trial, which was determined prior to unblinding and database lock. Read More

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http://dx.doi.org/10.1186/s13063-020-4103-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011285PMC
February 2020

Efficacy and safety of TNF blockers and of ustekinumab in palmoplantar pustulosis and in acrodermatitis continua of Hallopeau.

J Eur Acad Dermatol Venereol 2020 Feb 6. Epub 2020 Feb 6.

Dermatology Department, Hôpital Robert-Debré, Reims, France.

Background: Palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH) are rare variants of psoriasis. Knowledge of the efficacy of biologics is scarce.

Objectives: To evaluate the real-life efficacy of tumour necrosis factor blockers and ustekinumab in PPP and in ACH. Read More

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http://dx.doi.org/10.1111/jdv.16265DOI Listing
February 2020

Interleukin-36: Structure, Signaling and Function.

Adv Exp Med Biol 2020 Feb 6. Epub 2020 Feb 6.

AbbVie Inc., North Chicago, IL, USA.

The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory protein (IL-1RAcP). The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. Assembled ternary complex brings together intracellular TIR domains of receptors which activate downstream NF-κB and MAPK signaling. Read More

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http://dx.doi.org/10.1007/5584_2020_488DOI Listing
February 2020

Practical compendium for psoriasis management.

Dermatol Ther 2020 Mar 27;33(2):e13243. Epub 2020 Feb 27.

Department of Biology, School of Sciences and Engineering, The American University in Cairo, New Cairo, Egypt.

Psoriasis management is complex and challenging. It should be tailored for each patient. Treatment strategy differs according to patient's age, sex, disease type, disease severity, burden on patient's quality of life, comorbidities, involvement of specific sites, and pregnancy. Read More

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http://dx.doi.org/10.1111/dth.13243DOI Listing
March 2020
1.478 Impact Factor

Pharmacological Management of Pediatric Pustular Psoriasis.

Paediatr Drugs 2020 Jun;22(3):265-277

Department of Dermatology, National Taiwan University Hospital, No. 7 Chung San South Road, Taipei, Taiwan.

Therapeutic management of pustular psoriasis remains a challenge despite the rapid advance in psoriasis research and the development of drugs, especially biologics. Treatment guidelines have been established for pustular psoriasis, but no controlled studies are present for juvenile pustular psoriasis (JPP). Search of the literature reveals that current evidence of JPP treatment is limited to case reports and case series. Read More

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http://dx.doi.org/10.1007/s40272-020-00383-6DOI Listing

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments.

Am J Clin Dermatol 2020 Jun;21(3):355-370

Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008, Warsaw, Poland.

Palmoplantar pustulosis (PPP) is a chronic, recurrent skin disease belonging to the spectrum of psoriasis. It is characterized by an eruption of sterile pustules on the palms and soles. Recent studies in PPP have focused on genetic differences between pustular phenotypes and the role of the innate immunological system and the microbiome in the etiopathogenesis of the disease. Read More

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http://dx.doi.org/10.1007/s40257-020-00503-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275027PMC

Plasma retinol as a predictive biomarker of disease activity and response to acitretin monotherapy in children with generalized pustular psoriasis.

J Eur Acad Dermatol Venereol 2020 Jun 21;34(6):e270-e272. Epub 2020 Feb 21.

Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1111/jdv.16244DOI Listing

A Case Report of a Patient with Turner Syndrome, Multiple Comorbidities, and Pustular Psoriasis: Correlation or Coincidence?

Case Rep Dermatol Med 2020 8;2020:5750309. Epub 2020 Jan 8.

Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Ave #1140, Miami, FL 33136, USA.

Turner syndrome (TS) is one of the most common chromosomal abnormalities. Patients with TS are at an increased risk for the development of metabolic syndrome, hypertension (HTN), diabetes mellitus type II (DM2), hyperlipidemia (HLD), obesity, and cardiovascular disease. The association between psoriasis and the aforementioned conditions including metabolic syndrome, HTN, HLD, obesity, and cardiovascular disease has also been established. Read More

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http://dx.doi.org/10.1155/2020/5750309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970507PMC
January 2020

Psoriasis and Genetics.

Acta Derm Venereol 2020 01 30;100(3):adv00030. Epub 2020 Jan 30.

Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Read More

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http://dx.doi.org/10.2340/00015555-3384DOI Listing
January 2020

Pustular Psoriasis: The Dawn of a New Era.

Authors:
Hervez Bachelez

Acta Derm Venereol 2020 Jan 30;100(3):adv00034. Epub 2020 Jan 30.

Department of Dermatology, Université de Paris; APHP Hôpital Louis, FR-75010 Paris, France.

Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although phenotypically and genetically distinct from psoriasis vulgaris, these subtypes may be associated with plaque psoriasis lesions, establishing the rationale for their inclusion in the psoriasis spectrum. Unlike psoriasis, however, their genetic background is thought to be mainly monogenic, as shown by the recent identification of mutations in 3 different genes of the skin innate immune system; IL36RN, CARD14 and AP1S3. Read More

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http://dx.doi.org/10.2340/00015555-3388DOI Listing
January 2020