1,503 results match your criteria Psoriasis Pustular


Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations.

Pharmacogenomics 2018 Jun 19. Epub 2018 Jun 19.

Pharmacology Department, Faculty of Medicine, University of Monastir, Tunisia.

Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient with IL36RN mutation has been reported. Herein, we reported an unusual case of AGEP caused by codeine in a patient with a history of psoriasis and confirmed by an oral provocation test. Read More

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Interleukin (IL)-8 and IL-36γ but not IL-36Ra are related to acrosyringia in pustule formation associated with palmoplantar pustulosis.

Clin Exp Dermatol 2018 Jun 12. Epub 2018 Jun 12.

Department of Dermatology, Peking Union Medical College Hospital, Beijing, China.

Background: Palmoplantar pustulosis (PPP) is a refractory, nonbacterial impetigo confined to the palms and soles. Its pathogenesis is still obscure, but it may be associated with the large eccrine sweat glands and pores of palmoplantar skin. PPP is considered to be a localized pustular psoriasis. Read More

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Juvenile interleukin-36 receptor antagonist deficiency (DITRA) with c.80T>C (p.Leu27Pro) mutation successfully treated with etanercept and acitretin.

JAAD Case Rep 2018 Mar 2;4(2):192-195. Epub 2018 Feb 2.

Department of Dermatology, Sophia Children's Hospital, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.

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RNA sequencing-based longitudinal transcriptomic profiling gives novel insights into the disease mechanism of generalized pustular psoriasis.

BMC Med Genomics 2018 Jun 5;11(1):52. Epub 2018 Jun 5.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Generalized pustular psoriasis (GPP) is a rare, episodic, potentially life-threatening inflammatory disease. However, the pathogenesis of GPP, and universally accepted therapies for treating it, remain undefined.

Methods: To better understand the disease mechanism of GPP, we performed a transcriptome analysis to profile the gene expression of peripheral blood mononuclear cells (PBMCs) from patients enrolled at the time of diagnosis and receiving follow-up treatment for up to 6 months. Read More

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Generalized pustular psoriasis - A model disease for specific targeted immunotherapy, systematic review.

Exp Dermatol 2018 May 31. Epub 2018 May 31.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Germany.

Generalized pustular psoriasis (GPP) psoriasis is a rare, multisystemic skin disease characterized by recurrent episodes of pustulation. GPP can be life-threatening and is often difficult to treat. In the era of precision medicine in dermatology, GPP stands exemplary for both challenges and chances - while new treatments offer great hope, there is urgent need for better definition and stratification of this severe and heterogeneous disease. Read More

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Impetigo Herpetiformis: Review of Pathogenesis, Complication, and Treatment.

Dermatol Res Pract 2018 4;2018:5801280. Epub 2018 Apr 4.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Impetigo herpetiformis (IH) is among rare dermatosis of pregnancy, which is currently considered as a form of generalized pustular psoriasis. It is diagnosed by characteristic lesions of erythematous patches and grouped pustules mostly in the third trimester of pregnancy and may have systemic associations. A variety of complications have been reported in the course of IH. Read More

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Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007-2016).

Dermatol Res Pract 2018 23;2018:4371471. Epub 2018 Apr 23.

Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the general population.

Aim: To evaluate the epidemiology and clinical characteristics of patients with psoriasis who seek treatment in outpatient dermatology clinics throughout hospitals in Malaysia.

Materials And Methods: Data were obtained from the Malaysian Psoriasis Registry (MPR). Read More

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Current State of Nanomedicines in the Treatment of Topical Infectious Disorders.

Recent Pat Antiinfect Drug Discov 2018 May 28. Epub 2018 May 28.

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh. India.

Background: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermine the need of development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives. Read More

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Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

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April 2018
3 Reads

Clinical and immunological effects of adsorptive myeloid lineage leukocyte apheresis in patients with immune disorders.

Authors:
Takuro Kanekura

J Dermatol 2018 May 21. Epub 2018 May 21.

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leukocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leukocytes. Reports on the clinical efficacy of GMA in patients with skin lesions have appeared in the published work. Dermatological diseases, which are known to respond to GMA, include pyoderma gangrenosum, skin lesions of Behçet's disease, rheumatoid arthritis, pustular psoriasis, psoriatic arthritis, adult-onset Still's disease, Sweet's syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus rashes. Read More

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May 2018
6 Reads

Brodalumab-induced palmar pustular eruption and joint swelling accompanied by muscle pains in two cases of psoriasis.

J Dermatol 2018 May 16. Epub 2018 May 16.

Hosui General Medical Clinic, Research Institute of Psoriasis, Sapporo, Japan.

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May 2018
1 Read

A case of pustular psoriasis of pregnancy with positive maternal-fetal outcomes.

Cutis 2018 Apr;101(4):278-280

Department of Dermatology, University of Rochester, New York, USA.

Pustular psoriasis of pregnancy (PPP), also known as impetigo herpetiformis, is a rare condition that affects women in the third trimester of pregnancy through the postpartum period. The relative infrequency of PPP presents both clinical and pathologic challenges in the diagnosis and management of this condition. We report a case of a woman who presented at 32 weeks' gestation with a generalized rash demonstrating clinicopathologic features consistent with PPP. Read More

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April 2018
1 Read

Two cases of generalized pustular psoriasis complicated by IgG4-related disease.

Br J Dermatol 2018 Apr 30. Epub 2018 Apr 30.

Department of Dermatology, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan.

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Systemic Monotherapy Treatments for Generalized Pustular Psoriasis: A Systematic Review.

J Cutan Med Surg 2018 Apr 1:1203475418773358. Epub 2018 Apr 1.

3 Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Generalized pustular psoriasis (GPP) is a rare but serious and difficult to treat cutaneous disease, with high morbidity and mortality rates. Despite the numerous treatment regimens available, the overall quality of evidence-based research is limited with a lack of an algorithmic approach available. In this review, we aim to evaluate the current level of evidence regarding the efficacy and safety/tolerability of systemic monotherapies available in the treatment of GPP. Read More

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Paradoxical pustular psoriasis induced by ustekinumab in a patient with Crohn's disease-associated spondyloarthropathy.

Rheumatol Int 2018 07 28;38(7):1297-1299. Epub 2018 Apr 28.

Department of Rheumatology 1, Hôpital Sainte Marguerite, Assistance Publique, Hôpitaux de Marseille, Aix-Marseille University, 13009, Marseille, France.

Palmoplantar pustular psoriasis (PPP) is a clinical form of psoriasis, for which tumor necrosis factor alpha inhibitors (TNFi) or interleukins 12/23 inhibitor (ustekinumab) can be a therapeutic option. Paradoxical psoriatic reactions induced by TNFi are now well known. We present the exceptional case of a paradoxical PPP appeared under ustekinumab in a patient with Crohn's disease-associated spondyloarthropathy. Read More

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July 2018
2 Reads

Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis.

Authors:
Muriel Sadlier

JAAD Case Rep 2018 Apr 7;4(3):277. Epub 2018 Mar 7.

Department of Dermatology, St James's Hospital Dublin, Dublin, Ireland.

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Acute pustular eruption following a Jarisch-Herxheimer reaction in the treatment of syphilis.

JAAD Case Rep 2018 Apr 6;4(3):259-261. Epub 2018 Mar 6.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap.

Case Rep Dermatol 2018 Jan-Apr;10(1):69-75. Epub 2018 Mar 27.

Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.

Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. Read More

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Pediatric case of generalized pustular psoriasis developing acute pancreatitis.

J Dermatol 2018 Apr 14. Epub 2018 Apr 14.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

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Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations.

J Dermatol 2018 Apr 14. Epub 2018 Apr 14.

Department of Dermatology, University Medical Center Göttingen, Göttingen, Germany.

Generalized pustular psoriasis (GPP) is a potentially life-threatening disease that can be attributed to mutations in IL36RN in a subgroup of patients. In small trials, interleukin (IL)-17A and IL-17RA antagonists have been shown to be effective in patients with generalized pustular psoriasis in Japan. We identified seven patients who received the IL-17A antagonists secukinumab (six cases) or ixekizumab (one case) in two dermatological centers. Read More

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April 2018
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Association of IL36RN mutations with clinical features, therapeutic response to acitretin, and frequency of recurrence in patients with generalized pustular psoriasis.

Eur J Dermatol 2018 Apr;28(2):217-224

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.

Previous studies have revealed that IL36RN mutations play a pivotal role in the pathogenesis of generalized pustular psoriasis (GPP), however, the clinical relevance is unclear. To investigate the correlation between IL36RN mutations and clinical features, recurrence frequency, and therapeutic response to acitretin in GPP patients with long-term follow-up. This retrospective cohort study, lasting 2-4 years, included 61 GPP and 48 psoriasis vulgaris (PV) patients. Read More

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April 2018
5 Reads

The heterogeneous mutational landscape of pustular psoriasis.

Authors:
F Capon

Br J Dermatol 2018 Mar;178(3):589-590

School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, U.K.

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Generalized pustular psoriasis: a review and update on treatment.

J Eur Acad Dermatol Venereol 2018 Mar 24. Epub 2018 Mar 24.

Department of Dermatology, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. Read More

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March 2018
3 Reads

Guselkumab, a human interleukin-23 monoclonal antibody in Japanese patients with generalized pustular psoriasis and erythrodermic psoriasis: Efficacy and safety analyses of a 52-week, phase 3, multicenter, open-label study.

J Dermatol 2018 May 22;45(5):529-539. Epub 2018 Mar 22.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

Generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP) are the rare and severe subtypes of psoriasis, which are often difficult to treat. The aim of this phase 3, open-label study was to evaluate efficacy and safety of guselkumab, a human interleukin-23 monoclonal antibody, in Japanese patients with GPP and EP. Guselkumab 50 mg was administrated to GPP (n = 10) and EP (n = 11) patients at weeks 0, 4 and thereafter every 8 weeks (q8w). Read More

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Pharmacotherapeutic approaches for treating psoriasis in difficult-to-treat areas.

Expert Opin Pharmacother 2018 Apr 22;19(6):561-575. Epub 2018 Mar 22.

a Division of Dermatology , Baylor Scott and White , Dallas , TX , USA.

Introduction: Despite great therapeutic advancements in psoriasis, four notable difficult-to-treat areas including the scalp, nails, intertriginous (including genitals), and palmoplantar regions, pose a challenge to both physicians and patients. Localized disease of these specific body regions inflicts a significant burden on patients' quality of life and requires an adequate selection of treatments. Areas covered: This manuscript discusses appropriate therapies and important treatment considerations for these difficult-to-treat areas based on the available clinical data from the literature. Read More

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April 2018
2 Reads

Pustulotic Arthro-Osteitis (Sonozaki Syndrome): A Case Report and Review of Literature.

Eurasian J Med 2018 Feb 1;50(1):53-55. Epub 2018 Feb 1.

Department of Rheumatology, Adnan Menderes University, Aydın, Turkey.

Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different entity. Read More

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February 2018

Acute Generalised Exanthematous Pustulosis: An Update.

Indian J Dermatol 2018 Jan-Feb;63(1):22-29

Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is attributed to drugs in more than 90% of cases. It is a rare disease, with an estimated incidence of 1-5 patients per million per year. The clinical manifestations characterised by the rapid development of sterile pustular lesions, fever and leucocytosis. Read More

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March 2018
1 Read

Pustular psoriasis of pregnancy: current perspectives.

Int J Womens Health 2018 26;10:109-115. Epub 2018 Feb 26.

Department of Dermatology, University of California, San Francisco, CA, USA.

Pustular psoriasis of pregnancy (PPP) is a life-threatening condition for both the pregnant mother and fetus, and must be efficiently and accurately diagnosed and treated. This condition has historically been classified as a unique, separate dermatosis of pregnancy. However, current opinion and data suggest that it may be a variant of generalized pustular psoriasis. Read More

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February 2018

Generalized Pustular Psoriasis Induced by Infliximab in a Patient With Inflammatory Bowel Disease.

J Cutan Med Surg 2018 Feb 1:1203475418758986. Epub 2018 Feb 1.

1 Department of Medicine, Division of Dermatology, University of Toronto, Toronto, ON, Canada.

The incidence of anti-tumour necrosis factor (TNF)-induced psoriasiform eruptions has ranged in the literature between 0.5% and 10.9% of patients with inflammatory bowel disease (IBD). Read More

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February 2018
1 Read

Prevalence and type II diabetes-associated factors in psoriatic arthritis.

Clin Rheumatol 2018 Apr 22;37(4):1059-1064. Epub 2018 Feb 22.

Rheumatology Division, Department of Internal Medicine, Hospital Universitario Central de Asturias (HUCA), Avenida de Roma s/n, 33011, Oviedo, Spain.

Diabetes is a common cardiovascular risk factor in psoriatic arthritis (PsA). Although the prevalence of diabetes is high, the factors associated with it in PsA are poorly understood. We aimed to analyse the prevalence of type II diabetes and diabetes-associated factors in a hospital-based population with PsA. Read More

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An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency.

J Dermatol Sci 2018 May 6;90(2):216-218. Epub 2018 Feb 6.

Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address:

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May 2018
3 Reads

Pediatric pustular psoriasis responsive to cyclosporine bridged to etanercept: A treatment approach.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

New York Presbyterian/Weill Cornell Medical College, New York.

Pustular psoriasis occurs rarely in children but can present with acute toxicity requiring inpatient admission. For the best approach, medical providers should have an evidence based and systematic treatment algorithm in their armamentarium. Toillustrate this point, we describe a 13-year-old girl who was admitted with generalized pustular psoriasis and who responded dramatically to "wet wrap" therapy and cyclosporine bridged to etanercept. Read More

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November 2017
1 Read

RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature.

Front Immunol 2018 29;9:80. Epub 2018 Jan 29.

Department of Dermatology, University of Michigan, Ann Arbor, MI, United States.

IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, or IL-36G. We identified some early IL-1B-specific responses (8 h posttreatment), but nearly all late IL-1B responses were replicated by IL-36 cytokines (24 h posttreatment). Read More

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January 2018
1 Read

Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report.

Case Rep Dermatol 2017 Sep-Dec;9(3):259-264. Epub 2017 Dec 18.

Department of Dermatology, King Saud University Medical City, Riyadh, Saudi Arabia.

Acrodermatitis continua of Hallopeau (ACH) is an uncommon inflammatory disease manifesting as sterile pustular eruption of the fingers and toes. The disease is of a chronic relapsing nature and is often refractory to treatment. With longstanding disease, osteitis with consequent bone resorption of the underlying phalanges can occur, leading to disability. Read More

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December 2017
2 Reads

Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.

J Dermatol Sci 2018 May 1;90(2):105-111. Epub 2018 Feb 1.

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.

Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More

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May 2018
5 Reads

ARDS complicating pustular psoriasis: treatment with low-dose corticosteroids, vitamin C and thiamine.

BMJ Case Rep 2018 Feb 2;2018. Epub 2018 Feb 2.

Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.

We report the case of a 45-year-old Caucasian woman with a history of psoriasis, admitted to our Medical intensive care unit following the acute onset of diffuse rash and progressive dyspnoea and hypoxaemia requiring escalating respiratory support (continuous positive airway pressure of 10 cm HO). Her chest X-ray was consistent with findings of non-cardiogenic pulmonary oedema. Echocardiogram was normal. Read More

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February 2018
5 Reads

Comparison of effectiveness and safety of excimer lamp vs topical calcipotriol-clobetasol propionate combination in the treatment of palmoplantar psoriasis.

Photodermatol Photoimmunol Photomed 2018 Feb 8. Epub 2018 Feb 8.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Very few studies have assessed the efficacy of excimer in the treatment of palmoplantar psoriasis (PPP), and none has compared the excimer with calcipotriol-clobetasol propionate combination.

Purpose: To compare the effectiveness and safety of excimer lamp vs topical ointment containing calcipotriol (0.005% w/w) and clobetasol propionate (0. Read More

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February 2018

Increased levels of lipocalin 2 in palmoplantar pustular psoriasis.

J Dermatol Sci 2018 Apr 11;90(1):68-74. Epub 2018 Jan 11.

Psoriasis Research and Treatment Centre, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Background: Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles.

Objective: To identify and characterize pathogenetic players in PPP.

Methods: Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Read More

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April 2018
2 Reads

Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management.

Authors:
Eckart Haneke

Psoriasis (Auckl) 2017 16;7:51-63. Epub 2017 Oct 16.

Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.

Psoriasis is the skin disease that most frequently affects the nails. Depending on the very nail structure involved, different clinical nail alterations can be observed. Irritation of the apical matrix results in psoriatic pits, mid-matrix involvement may cause leukonychia, whole matrix affection may lead to red lunulae or severe nail dystrophy, nail bed involvement may cause salmon spots, subungual hyperkeratosis, and splinter hemorrhages, and psoriasis of the distal nail bed and hyponychium causes onycholysis whereas that of the proximal nail fold causes psoriatic paronychia. Read More

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October 2017
1 Read

How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?

An Bras Dermatol 2017 Nov-Dec;92(6):826-829

Department of Dermatology, Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.

Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. Read More

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April 2018
7 Reads

Psoriasis: from Pathogenesis to Targeted Therapies.

Clin Rev Allergy Immunol 2018 Feb;54(1):102-113

Department of Dermatology, Lausanne University Hospital CHUV, Lausanne, Switzerland.

Over the last decade, the management of psoriasis has witnessed a paradigm shift. Thanks to the increasing knowledge about the pathogenesis of psoriasis, targeted treatments with monoclonal antibodies have been developed. These antibodies, which target the pathogenic TNF/IL-23/IL-17-pathway, were shown to be safe and efficacious in the management of most patients with moderate to severe chronic plaque psoriasis. Read More

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February 2018
4 Reads

Secukinumab: a review of the anti-IL-17A biologic for the treatment of psoriasis.

Ther Adv Chronic Dis 2018 Jan 16;9(1):5-21. Epub 2017 Nov 16.

Baylor Scott and White- Division of Dermatology, 3900 Junius Street, Suite 125, Dallas, TX 75246, USA.

Psoriasis is a systemic inflammatory disease associated with numerous comorbidities and a profound impact on patients' quality of life. While its complex immune pathogenesis is still not fully delineated, current evidence supports a fundamental role of the T-helper-17 (TH-17) pathway and its related interleukin-17 (IL-17) cytokine. Thus, new antipsoriatic therapies have been developed to block this key cytokine and its downstream effects. Read More

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January 2018
4 Reads

Acute generalized pustular bacterid.

J Gen Fam Med 2018 01 1;19(1):32-33. Epub 2017 Nov 1.

Department of Dermatology Jichi Medical University Shimotsuke Japan.

The case of a 70-year-old Japanese man with acute generalized pustular bacterid. Read More

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January 2018
3 Reads

Comparison of guidelines for the use of TNF inhibitors for psoriasis in the United States, Canada, Europe and the United Kingdom: a critical appraisal and comprehensive review.

J Dermatolog Treat 2018 Feb 2:1-7. Epub 2018 Feb 2.

c Kaiser Permanente Los Angeles Medical Center Department of Dermatology , Los Angeles , CA , USA.

Purpose: To compare and contrast evidence-based CPGs from leading dermatological organizations for the use of tumor necrosis factor inhibitors (TNFi) in psoriasis.

Materials And Methods: Guidelines from the British National Institute for Health and Care Excellence (NICE), the British Association of Dermatologists (BAD), the American Academy of Dermatology (AAD), the National Psoriasis Foundation (NPF), and the Canadian Dermatology Association (CDA) were reviewed and compared.

Results: Various guidelines are similar regarding treatment initiation but have significant differences regarding topics such as continuous versus intermittent therapy, use in erythrodermic and pustular palmoplantar psoriasis and special patient populations. Read More

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February 2018
7 Reads