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    A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap.
    Case Rep Dermatol 2018 Jan-Apr;10(1):69-75. Epub 2018 Mar 27.
    Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.
    Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. Read More

    Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations.
    J Dermatol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Dermatology, University Medical Center Göttingen, Göttingen, Germany.
    Generalized pustular psoriasis (GPP) is a potentially life-threatening disease that can be attributed to mutations in IL36RN in a subgroup of patients. In small trials, interleukin (IL)-17A and IL-17RA antagonists have been shown to be effective in patients with generalized pustular psoriasis in Japan. We identified seven patients who received the IL-17A antagonists secukinumab (six cases) or ixekizumab (one case) in two dermatological centers. Read More

    Association of IL36RN mutation with clinical features, therapeutic response to acitretin, and frequency of recurrence in patients with generalized pustular psoriasis.
    Eur J Dermatol 2018 Apr 5. Epub 2018 Apr 5.
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
    Previous studies have revealed that IL36RN mutations play a pivotal role in the pathogenesis of generalized pustular psoriasis (GPP), however, the clinical relevance is unclear. To investigate the correlation between IL36RN mutations and clinical features, recurrence frequency, and therapeutic response to acitretin in GPP patients with long-term follow-up. This retrospective cohort study, lasting 2-4 years, included 61 GPP and 48 psoriasis vulgaris (PV) patients. Read More

    Generalized pustular psoriasis: a review and update on treatment.
    J Eur Acad Dermatol Venereol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Dermatology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
    Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. Read More

    Guselkumab, a human interleukin-23 monoclonal antibody in Japanese patients with generalized pustular psoriasis and erythrodermic psoriasis: Efficacy and safety analyses of a 52-week, phase 3, multicenter, open-label study.
    J Dermatol 2018 May 22;45(5):529-539. Epub 2018 Mar 22.
    Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
    Generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP) are the rare and severe subtypes of psoriasis, which are often difficult to treat. The aim of this phase 3, open-label study was to evaluate efficacy and safety of guselkumab, a human interleukin-23 monoclonal antibody, in Japanese patients with GPP and EP. Guselkumab 50 mg was administrated to GPP (n = 10) and EP (n = 11) patients at weeks 0, 4 and thereafter every 8 weeks (q8w). Read More

    Pharmacotherapeutic approaches for treating psoriasis in difficult-to-treat areas.
    Expert Opin Pharmacother 2018 Apr 22;19(6):561-575. Epub 2018 Mar 22.
    a Division of Dermatology , Baylor Scott and White , Dallas , TX , USA.
    Introduction: Despite great therapeutic advancements in psoriasis, four notable difficult-to-treat areas including the scalp, nails, intertriginous (including genitals), and palmoplantar regions, pose a challenge to both physicians and patients. Localized disease of these specific body regions inflicts a significant burden on patients' quality of life and requires an adequate selection of treatments. Areas covered: This manuscript discusses appropriate therapies and important treatment considerations for these difficult-to-treat areas based on the available clinical data from the literature. Read More

    Pustulotic Arthro-Osteitis (Sonozaki Syndrome): A Case Report and Review of Literature.
    Eurasian J Med 2018 Feb 1;50(1):53-55. Epub 2018 Feb 1.
    Department of Rheumatology, Adnan Menderes University, Aydın, Turkey.
    Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different entity. Read More

    Acute Generalised Exanthematous Pustulosis: An Update.
    Indian J Dermatol 2018 Jan-Feb;63(1):22-29
    Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.
    Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is attributed to drugs in more than 90% of cases. It is a rare disease, with an estimated incidence of 1-5 patients per million per year. The clinical manifestations characterised by the rapid development of sterile pustular lesions, fever and leucocytosis. Read More

    Pustular psoriasis of pregnancy: current perspectives.
    Int J Womens Health 2018 26;10:109-115. Epub 2018 Feb 26.
    Department of Dermatology, University of California, San Francisco, CA, USA.
    Pustular psoriasis of pregnancy (PPP) is a life-threatening condition for both the pregnant mother and fetus, and must be efficiently and accurately diagnosed and treated. This condition has historically been classified as a unique, separate dermatosis of pregnancy. However, current opinion and data suggest that it may be a variant of generalized pustular psoriasis. Read More

    Generalized Pustular Psoriasis Induced by Infliximab in a Patient With Inflammatory Bowel Disease.
    J Cutan Med Surg 2018 Feb 1:1203475418758986. Epub 2018 Feb 1.
    1 Department of Medicine, Division of Dermatology, University of Toronto, Toronto, ON, Canada.
    The incidence of anti-tumour necrosis factor (TNF)-induced psoriasiform eruptions has ranged in the literature between 0.5% and 10.9% of patients with inflammatory bowel disease (IBD). Read More

    Prevalence and type II diabetes-associated factors in psoriatic arthritis.
    Clin Rheumatol 2018 Apr 22;37(4):1059-1064. Epub 2018 Feb 22.
    Rheumatology Division, Department of Internal Medicine, Hospital Universitario Central de Asturias (HUCA), Avenida de Roma s/n, 33011, Oviedo, Spain.
    Diabetes is a common cardiovascular risk factor in psoriatic arthritis (PsA). Although the prevalence of diabetes is high, the factors associated with it in PsA are poorly understood. We aimed to analyse the prevalence of type II diabetes and diabetes-associated factors in a hospital-based population with PsA. Read More

    An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency.
    J Dermatol Sci 2018 Feb 6. Epub 2018 Feb 6.
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address:

    Pediatric pustular psoriasis responsive to cyclosporine bridged to etanercept: A treatment approach.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    New York Presbyterian/Weill Cornell Medical College, New York.
    Pustular psoriasis occurs rarely in children but can present with acute toxicity requiring inpatient admission. For the best approach, medical providers should have an evidence based and systematic treatment algorithm in their armamentarium. Toillustrate this point, we describe a 13-year-old girl who was admitted with generalized pustular psoriasis and who responded dramatically to "wet wrap" therapy and cyclosporine bridged to etanercept. Read More

    RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature.
    Front Immunol 2018 29;9:80. Epub 2018 Jan 29.
    Department of Dermatology, University of Michigan, Ann Arbor, MI, United States.
    IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, or IL-36G. We identified some early IL-1B-specific responses (8 h posttreatment), but nearly all late IL-1B responses were replicated by IL-36 cytokines (24 h posttreatment). Read More

    Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report.
    Case Rep Dermatol 2017 Sep-Dec;9(3):259-264. Epub 2017 Dec 18.
    Department of Dermatology, King Saud University Medical City, Riyadh, Saudi Arabia.
    Acrodermatitis continua of Hallopeau (ACH) is an uncommon inflammatory disease manifesting as sterile pustular eruption of the fingers and toes. The disease is of a chronic relapsing nature and is often refractory to treatment. With longstanding disease, osteitis with consequent bone resorption of the underlying phalanges can occur, leading to disability. Read More

    Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.
    J Dermatol Sci 2018 Feb 1. Epub 2018 Feb 1.
    Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
    Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More

    ARDS complicating pustular psoriasis: treatment with low-dose corticosteroids, vitamin C and thiamine.
    BMJ Case Rep 2018 Feb 2;2018. Epub 2018 Feb 2.
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.
    We report the case of a 45-year-old Caucasian woman with a history of psoriasis, admitted to our Medical intensive care unit following the acute onset of diffuse rash and progressive dyspnoea and hypoxaemia requiring escalating respiratory support (continuous positive airway pressure of 10 cm HO). Her chest X-ray was consistent with findings of non-cardiogenic pulmonary oedema. Echocardiogram was normal. Read More

    Comparison of effectiveness and safety of excimer lamp vs topical calcipotriol-clobetasol propionate combination in the treatment of palmoplantar psoriasis.
    Photodermatol Photoimmunol Photomed 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Very few studies have assessed the efficacy of excimer in the treatment of palmoplantar psoriasis (PPP), and none has compared the excimer with calcipotriol-clobetasol propionate combination.

    Purpose: To compare the effectiveness and safety of excimer lamp vs topical ointment containing calcipotriol (0.005% w/w) and clobetasol propionate (0. Read More

    Increased levels of lipocalin 2 in palmoplantar pustular psoriasis.
    J Dermatol Sci 2018 Apr 11;90(1):68-74. Epub 2018 Jan 11.
    Psoriasis Research and Treatment Centre, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
    Background: Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles.

    Objective: To identify and characterize pathogenetic players in PPP.

    Methods: Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Read More

    Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management.
    Psoriasis (Auckl) 2017 16;7:51-63. Epub 2017 Oct 16.
    Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.
    Psoriasis is the skin disease that most frequently affects the nails. Depending on the very nail structure involved, different clinical nail alterations can be observed. Irritation of the apical matrix results in psoriatic pits, mid-matrix involvement may cause leukonychia, whole matrix affection may lead to red lunulae or severe nail dystrophy, nail bed involvement may cause salmon spots, subungual hyperkeratosis, and splinter hemorrhages, and psoriasis of the distal nail bed and hyponychium causes onycholysis whereas that of the proximal nail fold causes psoriatic paronychia. Read More

    How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?
    An Bras Dermatol 2017 Nov-Dec;92(6):826-829
    Department of Dermatology, Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.
    Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. Read More

    Psoriasis: from Pathogenesis to Targeted Therapies.
    Clin Rev Allergy Immunol 2018 Feb;54(1):102-113
    Department of Dermatology, Lausanne University Hospital CHUV, Lausanne, Switzerland.
    Over the last decade, the management of psoriasis has witnessed a paradigm shift. Thanks to the increasing knowledge about the pathogenesis of psoriasis, targeted treatments with monoclonal antibodies have been developed. These antibodies, which target the pathogenic TNF/IL-23/IL-17-pathway, were shown to be safe and efficacious in the management of most patients with moderate to severe chronic plaque psoriasis. Read More

    Secukinumab: a review of the anti-IL-17A biologic for the treatment of psoriasis.
    Ther Adv Chronic Dis 2018 Jan 16;9(1):5-21. Epub 2017 Nov 16.
    Baylor Scott and White- Division of Dermatology, 3900 Junius Street, Suite 125, Dallas, TX 75246, USA.
    Psoriasis is a systemic inflammatory disease associated with numerous comorbidities and a profound impact on patients' quality of life. While its complex immune pathogenesis is still not fully delineated, current evidence supports a fundamental role of the T-helper-17 (TH-17) pathway and its related interleukin-17 (IL-17) cytokine. Thus, new antipsoriatic therapies have been developed to block this key cytokine and its downstream effects. Read More

    Comparison of guidelines for the use of TNF inhibitors for psoriasis in the United States, Canada, Europe and the United Kingdom: a critical appraisal and comprehensive review.
    J Dermatolog Treat 2018 Feb 2:1-7. Epub 2018 Feb 2.
    c Kaiser Permanente Los Angeles Medical Center Department of Dermatology , Los Angeles , CA , USA.
    Purpose: To compare and contrast evidence-based CPGs from leading dermatological organizations for the use of tumor necrosis factor inhibitors (TNFi) in psoriasis.

    Materials And Methods: Guidelines from the British National Institute for Health and Care Excellence (NICE), the British Association of Dermatologists (BAD), the American Academy of Dermatology (AAD), the National Psoriasis Foundation (NPF), and the Canadian Dermatology Association (CDA) were reviewed and compared.

    Results: Various guidelines are similar regarding treatment initiation but have significant differences regarding topics such as continuous versus intermittent therapy, use in erythrodermic and pustular palmoplantar psoriasis and special patient populations. Read More

    Pustular psoriasis and related pustular skin diseases.
    Br J Dermatol 2018 Mar 15;178(3):614-618. Epub 2018 Jan 15.
    Department of Dermatology, AP-HP Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris CEDEX 10, 75475, France.
    Patients with pustular psoriasis or related pustular diseases may have genetic abnormalities impairing the function of key players of the innate skin immune system. Recently, identification of these abnormalities has changed the paradigm of several of these diseases. These include generalized pustular psoriasis, palmoplantar pustular psoriasis and acrodermatitis continua of Hallopeau, and also drug-induced acute exanthematous generalized pustular eruption. Read More

    Evaluation of ICAM-1 expression and vascular changes in the skin of patients with plaque, pustular, and erythrodermic psoriasis.
    Int J Dermatol 2018 Feb 10;57(2):209-216. Epub 2018 Jan 10.
    Sector of Dermatology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
    Background: Psoriasis is a chronic inflammatory disease. Pustular, erythrodermic, and extensive plaque psoriasis are responsible for systemic complications. Systemic capillary leak syndrome is the complication with greater progression to death and occurs due to vascular changes. Read More

    Unopposed IL-36 Activity Promotes Clonal CD4 T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis.
    J Invest Dermatol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Dermatology and Allergology, University Hospital, Ludwig-Maximilian-University, Munich, Germany. Electronic address:
    Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory etiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signaling promotes antigen-driven and likely pathogenic T-helper type 17 (Th17) responses in GPP. Read More

    Pemphigus foliaceus with pustular presentation in a patient with psoriasis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):115-117
    Dermatology Department at Hospital Universitário Pedro Ernesto, of the Universidade do Estado do Rio de Janeiro (Hupe-Uerj) - Rio de Janeiro (RJ), Brazil.
    Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. Read More

    Histopathological aspects of psoriasis and its uncommon variants.
    G Ital Dermatol Venereol 2018 Apr 15;153(2):173-184. Epub 2017 Dec 15.
    Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
    Psoriasis is a chronic complex multisystem, inflammatory, skin disorder that causes vasodilatation and hyperproliferation of keratinocytes, whose clinical expression includes a thickened, erythematous skin, often covered with silver gray scales. Psoriasis is a unique disease where both autoimmune and autoinflammatory responses coexist and the balance between the two components is essential in determining its clinical and histopathological presentation. Adaptive immune responses prevail in chronic plaque psoriasis while innate and autoinflammatory responses predominate in pustular psoriasis. Read More

    Immunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions.
    J Immunol Res 2017 31;2017:6928363. Epub 2017 Oct 31.
    Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
    Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Read More

    Generalized pustular psoriasis in a 92-year-old man with a homozygous nonsense mutation in IL36RN.
    J Dermatol 2018 Mar 7;45(3):326-328. Epub 2017 Dec 7.
    Department of Dermatology, Jichi Medical University, Shimotsuke, Japan.
    A 92-year-old man developed an erythematous eruption on the trunk and extremities with numerous pustules accompanied by fever. He had never experienced pustular eruption or been diagnosed with psoriasis previously. Skin biopsy revealed Kogoj's spongiform pustule, and he was diagnosed with generalized pustular psoriasis (GPP). Read More

    Clinical features of von Zumbusch type of generalized pustular psoriasis in children: a retrospective study of 26 patients in southwestern China.
    An Bras Dermatol 2017 May-Jun;92(3):319-322
    The Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital - Chengdu, China.
    Background: Von Zumbusch type of generalized pustular psoriasis is a rare variant of psoriasis in children. It can occur in patients with or without psoriasis vulgaris.

    Objective: The aim of the study was to discuss the precipitating factors, clinical manifestations, laboratory data and therapy of von Zumbusch type of generalized pustular psoriasis in children from southwestern China and to improve the diagnosis and treatment level. Read More

    Abrupt generalized pustules in patients with rheumatoid arthritis and interstitial lung disease.
    J Dermatol 2018 Feb 23;45(2):198-201. Epub 2017 Nov 23.
    Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
    We report a case of a 30-year-old Chinese woman with rheumatoid arthritis and interstitial lung disease who abruptly developed generalized pustules and a high fever for 10 days. She had been taking oral prednisone, iguratimod and total glucosides of peony regularly for 5 months prior. In addition, she had taken metronidazole for 3 days 20 days prior which she had used before with no adverse reaction. Read More

    The Efficacy of Biologic Therapy for the Management of Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review.
    Dermatol Ther (Heidelb) 2017 Dec 15;7(4):425-446. Epub 2017 Nov 15.
    Department of Dermatology, University of California San Francisco, San Francisco, USA.
    Introduction: Palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) are diseases affecting the hands and/or feet that can cause marked physical discomfort and functional disability. The tumor necrosis factor-alpha antagonists adalimumab, etanercept, and infliximab, the interleukin (IL)-17A inhibitors ixekizumab and secukinumab, and the IL-23 or IL-12/IL-23 inhibitors guselkumab and ustekinumab have been well studied for the treatment of moderate to severe plaque psoriasis. Less is known about the efficacy and safety of these agents for the treatment of PP (hyperkeratotic and pustular forms) and PPP. Read More

    Paradoxical Reactions: Anti-Tumor Necrosis Factor Alpha Agents, Ustekinumab, Secukinumab, Ixekizumab, and Others.
    Curr Probl Dermatol 2018 7;53:49-63. Epub 2017 Nov 7.
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease. Paradoxical reactions have subsequently been reported with other biological drugs or classes (e. Read More

    Epidemiological survey from 2009 to 2012 of psoriatic patients in Japanese Society for Psoriasis Research.
    J Dermatol 2018 Mar 8;45(3):293-301. Epub 2017 Nov 8.
    Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
    Since 1982, the Japanese Society for Psoriasis Research has conducted annual epidemiological surveys of patients with psoriasis. Kawada et al. have reported data for 1982-2001 and Takahashi et al. Read More

    Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review.
    J Dermatolog Treat 2017 Nov 9:1-11. Epub 2017 Nov 9.
    c Institute of Dermatology , Guangzhou Medical University , Guangzhou , P.R. China.
    Background: There is a few evidence-based information regarding the efficacy and safety of acitretin treatment in children with pustular psoriasis (PP).

    Objective: This study aimed to provide an additional evidence for this field.

    Methods: A retrospective study was undertaken for 15 children with PP who received acitretin in doses of 0. Read More

    A mysterious abdominal pain during active psoriasis.
    Intern Emerg Med 2017 Oct 30. Epub 2017 Oct 30.
    Dipartimento di Fisiopatologia Medico-Chirurgica E dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, IRCCS Fondazione Ca' Granda, Ospedale maggiore Policlinico, via Pace 9, 24125, Milan, Italy.

    The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: Immunophenotyping and response to ustekinumab.
    J Am Acad Dermatol 2018 Mar 21;78(3):498-505.e2. Epub 2017 Oct 21.
    Department of Dermatology, Mount Sinai School of Medicine, New York, New York.
    Background: The immune abnormalities underlying the ichthyoses are poorly understood.

    Objective: To determine the immunophenotype of an ichthyosis resulting from mutations in the spectrin repeat 6 (SR6) domain of desmoplakin gene (DSP) and target therapy on the basis of molecular pathogenesis.

    Methods: Immunophenotyping was performed by using the blood and skin of a girl with SR6 region DSP mutations causing erythroderma/ichthyosis and cardiomyopathy. Read More

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