1,570 results match your criteria Psoriasis Pustular


A case of Generalized Pustular Psoriasis and arthritis treated with ixekizumab.

J Dermatolog Treat 2019 Apr 18:1-7. Epub 2019 Apr 18.

a Department of Dermatology , Univeristy of Rome "Tor Vergata" , Rome , Italy.

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http://dx.doi.org/10.1080/09546634.2019.1606395DOI Listing

A case of pustular psoriasis possibly precipitated by estrogen/gestagen periodic therapy for Turner syndrome.

Clin Exp Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Osaka City General Hospital, Osaka.

Patients with Turner syndrome have an X chromosome abnormality in that they have only one X chromosome or show partial deletion of the X chromosome or mosaicism with an abnormal X chromosome. To compensate for the ovary dysfunction and restore bone density, estrogen/gestagen periodic therapy (Kaufmann therapy) is essential for patients with Turner syndrome. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/ced.13979DOI Listing
April 2019
1 Read

Long-term effects of biologic therapies on peripheral blood eosinophils in patients with psoriasis: A 3-year single-centre study.

J Dermatolog Treat 2019 Apr 8:1-20. Epub 2019 Apr 8.

a Department of Dermatology and Venereology , Hacettepe University, School of Medicine , Ankara , Turkey.

Background: Biologic therapies (BTs),etanercept, infliximab, adalimumab, ustekinumab, are generally well-tolerated and safe agents in psoriasis management.

Objectives: To determine the overall effect of BTs on peripheral blood eosinophil count(PBEc) and percentage(PBEp), peripheral blood basophil count(PBBc) and percentage(PBBp), white blood cell count(WBCc),erythrocyte sedimentation rate(ESR),and serum C-reactive protein(s-CRP) level during a 3-year follow-up in patients with psoriasis.

Methods: This retrospective cohort study included 200 patients(116 men;84 women) treated continuously with BTs for 3 years for plaque-type, pustular, or nail psoriasis. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605139DOI Listing
April 2019
1 Read

Favorable response to apremilast in a patient with refractory psoriasis verrucosa.

J Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan.

A 67-year-old man, who had been diagnosed with psoriasis 30 years prior, visited our hospital with a complaint of verrucous nodules in the lower legs, which had developed 15 years previously. We diagnosed him as having psoriasis verrucosa of the legs and plaque psoriasis of the torso. Because the lesions were resistant to topical glucocorticoids and vitamin D , a verrucous lesion in the right leg was treated with surgical ablation, which resulted in the development of generalized pustular psoriasis. Read More

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http://dx.doi.org/10.1111/1346-8138.14877DOI Listing
April 2019
1 Read

The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review.

J Cutan Med Surg 2019 Apr 2:1203475419836435. Epub 2019 Apr 2.

3 SKiN Centre for Dermatology, Peterborough, ON, Canada.

Acrodermatitis continua of Hallopeau is a rare subtype of pustular psoriasis that presents as a sterile, pustular eruption commonly in the finger tips and toes. This disease inflicts both the skin and nail bed, and causes severe disfigurement of the distal phalanges. Because it is a variant of pustular psoriasis, acrodermatitis continua of Hallopeau is commonly managed with antipsoriatic medications. Read More

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http://dx.doi.org/10.1177/1203475419836435DOI Listing
April 2019
1 Read

Association of geographic tongue and fissured tongue with ABO blood group among adult psoriasis patients: a novel study from a tertiary care hospital in Saudi Arabia.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 7. Epub 2019 Feb 7.

Assistant Professor, Department of Periodontics and Community Sciences, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.

Objective: We aimed to determine if there was any association between geographic tongue (GT) and fissured tongue with ABO blood group among adult psoriasis patients in Saudi Arabia.

Study Design: This hospital-based cross-sectional study included 100 consecutive new adult patients diagnosed with psoriasis and 100 case-matched participants in the control group (nonpsoriatic). Sociodemographic and dermatologic parameters, intraoral lesions (GT and fissured tongue), and ABO blood grouping and immunoglobulins were recorded and evaluated using χ or Fisher's exact test. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.01.080DOI Listing
February 2019

Acrodermatitis continua of Hallopeau response to optimized biological therapy.

Dermatol Online J 2019 Feb 15;25(2). Epub 2019 Feb 15.

Department of Dermatology, Amiens University Hospital, Amiens.

Acrodermatitis continua of Hallopeau, first described in 1890, is an uncommon variant of pustular psoriasis. It presents as a sterile pustular eruption of the tips of fingers and toes. The condition has a chronic, relapsing course and is often resistant to many anti-psoriatic therapies. Read More

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February 2019
6 Reads

Generalized pustular psoriasis from heterozygous IL36RN mutation developed after liver surgery.

J Dermatol 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.

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http://dx.doi.org/10.1111/1346-8138.14828DOI Listing
March 2019
1 Read

Characteristics and prevalence of plaque psoriasis in patients with palmoplantar pustulosis.

Br J Dermatol 2019 Feb 28. Epub 2019 Feb 28.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Palmoplantar pustulosis (PPP) is a chronic pustular skin condition on palms and soles. The disease is often seen in combination with plaque psoriasis, and whether PPP is a variant of psoriasis has been debated. The disease prevalence of PPP and co-occurring psoriasis is not yet established and the patient group remains understudied. Read More

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http://dx.doi.org/10.1111/bjd.17832DOI Listing
February 2019
3 Reads

Neutrophil exosomes enhance the skin autoinflammation in generalized pustular psoriasis via activating keratinocytes.

FASEB J 2019 Feb 27:fj201802090RR. Epub 2019 Feb 27.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease that can be life-threatening. Gene mutations are found in some cases, but its immune pathogenesis is largely unknown. Here, we observed that the neutrophil:lymphocyte ratio in patients with GPP was higher than that in healthy controls and decreased after effective treatment. Read More

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http://dx.doi.org/10.1096/fj.201802090RRDOI Listing
February 2019
2 Reads

Pustular DRESS Syndrome Secondary to Hydroxychloroquine With EBV Reactivation

J Drugs Dermatol 2019 Feb;18(2):207-209

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) or drug-induced hypersensitivity (DIHS) is a rare and feared complication of frequently used medications such as anticonvulsants, sulfonamides, and allopurinol. To date, no reports of hydroxychloroquine-induced pustular DRESS syndrome have been associated with Epstein-Barr virus (EBV) reactivation nor imitated other cutaneous adverse drug reactions as in our patient. Observation: A 56-year-old female presented with a diffuse cutaneous eruption involving the face, trunk, extremities, and palms approximately two weeks after the initiation of hydroxychloroquine therapy for a suspected Sjögren's-like process with inflammatory cervical lymphadenopathy. Read More

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February 2019
18 Reads

Interleukin-17 receptor A blockade with brodalumab in palmoplantar pustular psoriasis: Report on four cases.

J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Venereology and Allergology, University Clinic Göttingen, Göttingen, Germany.

Palmoplantar pustular psoriasis, also termed palmoplantar pustulosis (PPP), is a rare disease affecting the palmoplantar regions characterized by sterile, yellow to brown pustules mostly on erythematous skin. PPP is related to a high burden due to painful, impaired and stigmatizing character. Several isoforms of interleukin (IL) have been implicated in its pathophysiology. Read More

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http://dx.doi.org/10.1111/1346-8138.14815DOI Listing
February 2019
1 Read

Acute generalized exanthematous pustulosis (AGEP) and psoriasis: what can be learned from co-morbidities. A comparative study.

G Ital Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Venereology, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Acute generalized exanthematous pustulosis (AGEP) is a rare pustular severe cutaneous adverse reaction. Differentiating between AGEP and pustular psoriasis may represent a diagnostic challenge. We sought to evaluate the prevalence of co-morbidities in a series of patients with AGEP compared to a series of patients with psoriasis vulgaris and to a series of patients with drug related psoriasis. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06157-1DOI Listing
February 2019
2 Reads

Long-term efficacy of ixekizumab in erythrodermic and generalized pustular psoriasis patients.

J Eur Acad Dermatol Venereol 2019 Feb;33(2):259

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/jdv.15416DOI Listing
February 2019

Clinical Aspects and Treatment of Pityriasis Lichenoides Et Varioliformis Acuta: A Retrospective Vietnamese Study.

Open Access Maced J Med Sci 2019 Jan 23;7(2):198-199. Epub 2019 Jan 23.

University of Rome G. Marconi, Rome, Italy.

Background: Pityriasis lichenoides et varioliformis acuta (PLEVA) is an uncommon condition which presents acutely with papulo-vesicles that may develop necrotic, ulcerative, or hemorrhagic changes.

Aim: We studied clinical, and treatment characteristics of PLEVA hospitalised patients at our hospital from September 2009 to December 2014.

Methods: The records of 15 PLEVA patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.3889/oamjms.2019.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364730PMC
January 2019
3 Reads

First presentation of Sneddon-Wilkinson disease with unexpected immunoglobulin A gammopathy: A case report and review of the literature.

SAGE Open Med Case Rep 2019 30;7:2050313X19826432. Epub 2019 Jan 30.

University of Saskatchewan, Saskatoon, SK, Canada.

We present a case of Sneddon-Wilkinson disease in a 52-year-old female at her first presentation to dermatology. Outlined in the case are various investigations undertaken at this initial presentation, including rheumatologic and hematologic malignancy markers, which identified immunoglobulin A gammopathy. The systemic and topical therapies used to treat the patient's condition are described, as well as her response to these treatments. Read More

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http://dx.doi.org/10.1177/2050313X19826432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354295PMC
January 2019
3 Reads

Efficacy of Chemokine Receptor Inhibition in Treating IL-36α-Induced Psoriasiform Inflammation.

J Immunol 2019 Mar 4;202(6):1687-1692. Epub 2019 Feb 4.

ChemoCentryx, Inc., Mountain View, CA 94043.

Several types of psoriasiform dermatitis are associated with increased IL-36 cytokine activity in the skin. A rare, but severe, psoriasis-like disorder, generalized pustular psoriasis (GPP), is linked to loss-of-function mutations in the gene encoding IL-36RA, an important negative regulator of IL-36 signaling. To understand the effects of IL-36 dysregulation in a mouse model, we studied skin inflammation induced by intradermal injections of preactivated IL-36α. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801519
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http://dx.doi.org/10.4049/jimmunol.1801519DOI Listing
March 2019
11 Reads

Secukinumab for moderate-to-severe palmoplantar pustular psoriasis: Results of the 2PRECISE study.

J Am Acad Dermatol 2019 May 1;80(5):1344-1352. Epub 2019 Feb 1.

Novartis Pharma AG, Basel, Switzerland.

Background: Palmoplantar pustular psoriasis (PPP) is a debilitating disease of the palms and/or soles that is resistant to treatment. Secukinumab, an anti-interleukin 17A monoclonal antibody, is highly efficacious in the treatment of moderate-to-severe psoriasis.

Objective: The primary objective was to determine the rate of achievement of a 75% improvement from baseline in Palmoplantar Psoriasis Area and Severity Index (PPPASI75) with secukinumab at week 16 versus with placebo (at a 2. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.066DOI Listing
May 2019
9 Reads

Treatment resistant impetigo herpetiformis treated with infliximab.

Dermatol Ther 2019 Mar 12;32(2):e12839. Epub 2019 Feb 12.

Department of Pathology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Impetigo herpetiformis is a rare disease of pregnancy with the onset being in the second half of pregnancy and resolution after delivery. It is associated with a high rate of perinatal mortality and fetal abnormalities. Clinical and histological features of the disease are consistent with pustuler psoriasis. Read More

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http://doi.wiley.com/10.1111/dth.12839
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http://dx.doi.org/10.1111/dth.12839DOI Listing
March 2019
7 Reads

The impact of having family history of psoriasis or psoriatic arthritis on psoriatic disease.

Arthritis Care Res (Hoboken) 2019 Jan 25. Epub 2019 Jan 25.

University of Ottawa, Faculty of Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Objective: Psoriatic arthritis (PsA) has a genetic background. Approximately 40% of patients have a family history of psoriasis or PsA, which may affect disease features. The aim of this study was to assess the effects of family history of psoriasis and PsA on disease phenotypes. Read More

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http://dx.doi.org/10.1002/acr.23836DOI Listing
January 2019
18 Reads

Development of herpes zoster during infliximab treatment for pediatric generalized pustular psoriasis: A case report.

Dermatol Ther 2019 Mar 17;32(2):e12838. Epub 2019 Feb 17.

Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.

The present authors report a 12-year-old Chinese child with generalized pustular psoriasis who was responded well to infliximab, but an adverse effect of herpes zoster occurred after the first infusion soon. The antiviral treatment was effective and no recurrence or flaring was observed after half-year of follow-up. This case reminds us to highlight the risk of viral infection during biological treatment on patients with psoriasis or autoimmune disease. Read More

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http://dx.doi.org/10.1111/dth.12838DOI Listing
March 2019
15 Reads

Distinguishing pustular psoriasis and acute generalized exanthematous pustulosis on the basis of plasmacytoid dendritic cells and MxA protein.

J Cutan Pathol 2019 May 21;46(5):317-326. Epub 2019 Feb 21.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.

Background: Distinguishing acute generalized exanthematous pustulosis (AGEP) and pustular psoriasis (PS) can be challenging. Staining for plasmacytoid dendritic cells, or PDCs (producer of IFN-α/β), and MxA (an IFN-α/β inducible protein) may help discriminate these entities.

Methods: Forty-three cases of AGEP and PS were compiled from two academic institutions. Read More

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http://dx.doi.org/10.1111/cup.13430DOI Listing
May 2019
1 Read
1.560 Impact Factor

A Novel Desensitization Protocol for Infliximab hypersensitivity in a 13-Year Old Patient with Pustular Psoriasis.

Curr Drug Saf 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacology, Sri Ramachandra Institute of Higher Education and Research, Chennai. India.

Background: Drug hypersensitivity reactions to infliximab have been reported in pediatric patients. At times, these patients may need infliximab administration in spite of hypersensitivity. However, only a few reports of desensitization protocols are available in the literature in pediatric patients. Read More

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http://dx.doi.org/10.2174/1574886314666190119115632DOI Listing
January 2019
12 Reads

Diagnosis and Management of Cutaneous Psoriasis: A Review.

Adv Skin Wound Care 2019 Feb;32(2):58-69

Alisa Brandon, MSc • Medical Student • University of Toronto • Toronto, Ontario, Canada Asfandyar Mufti, MD • Dermatology Resident • University of Toronto • Toronto, Ontario, Canada R. Gary Sibbald, DSc (Hons), MD, MEd, BSc, FRCPC (Med Derm), ABIM, FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course and Masters of Science in Community Health (Prevention and Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Editor-in-Chief • Advances in Skin and Wound Care • Philadelphia, Pennsylvania.

General Purpose: To provide information about the diagnosis and management of cutaneous psoriasis.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After completing this continuing education activity, the provider should be better able to: ABSTRACT: Psoriasis is a chronic inflammatory disease that is characterized by plaque, inverse, guttate, pustular, and erythrodermic variants. Read More

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http://dx.doi.org/10.1097/01.ASW.0000550592.08674.43DOI Listing
February 2019
13 Reads
1.634 Impact Factor

Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis.

Dis Markers 2018 16;2018:9758473. Epub 2018 Dec 16.

Department of Dermatology, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.

Patients with generalized pustular psoriasis (GPP) often present with symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT and P-SEP levels in patients with psoriatic diseases. The enrolled patients included 27 with psoriasis vulgaris (PV) (22 males, 5 females; mean age 47. Read More

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http://dx.doi.org/10.1155/2018/9758473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311837PMC
December 2018
2 Reads

Differential Expression of IL-36 Family Members and IL-38 by Immune and Nonimmune Cells in Patients with Active Inflammatory Bowel Disease.

Biomed Res Int 2018 10;2018:5140691. Epub 2018 Dec 10.

Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico.

IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), the IL-36, IL-36, IL-36, IL-36Ra, and IL-38 gene and cell expression and its correlation with clinical activity. . Read More

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https://www.hindawi.com/journals/bmri/2018/5140691/
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http://dx.doi.org/10.1155/2018/5140691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311241PMC
December 2018
11 Reads

Polymorphisms in IL36G gene are associated with plaque psoriasis.

BMC Med Genet 2019 Jan 11;20(1):10. Epub 2019 Jan 11.

Department of Dermatology and Venerology, University of Tartu, 31 Raja St, 50417, Tartu, Estonia.

Background: Plaque psoriasis is a non-contagious skin disease in which characteristic red and flaky lesions result from a dysregulation involving both innate and adaptive immune mechanisms. Several cytokines have been implicated in these processes and lately interleukin (IL)-36 family members have become more recognised among them. Thus far, genetic studies have only investigated IL36RN gene of this family in relation to pustular psoriasis. Read More

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http://dx.doi.org/10.1186/s12881-018-0742-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330488PMC
January 2019
5 Reads

Evaluation of generalized pustular psoriasis by reflectance confocal microscopy.

Skin Res Technol 2019 Jan 5. Epub 2019 Jan 5.

Department of Surgical, Medical, Dental and Morphological Sciences with Interest Transplant, Oncological and Regenerative Medicine, Modena, Italy.

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http://doi.wiley.com/10.1111/srt.12655
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http://dx.doi.org/10.1111/srt.12655DOI Listing
January 2019
14 Reads

Early-onset generalized pustular psoriasis is representative of autoinflammatory keratinization diseases.

Authors:
Masashi Akiyama

J Allergy Clin Immunol 2019 Feb 1;143(2):809-810. Epub 2019 Jan 1.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.11.009DOI Listing
February 2019
3 Reads

[What's new in dermatological treatment?]

Authors:
V Descamps

Ann Dermatol Venereol 2018 Dec;145 Suppl 7:VIIS47-VIIS55

Service de dermatologie, Hôpital Bichat, université Paris 7, Paris, France. Electronic address:

The therapeutic revolution in the management of inflammatory dermatoses is under way. The therapeutic arsenal is expanding in the field of psoriasis, including biologics (TNF blockers, anti-IL12/IL23, anti-IL17, and anti-IL23 antibodies), new small molecules (tyrosine kinase inhibitor), and a new biologic for generalized pustular psoriasis (anti-IL36 receptor). New biologics will be soon available in the field of atopic dermatitis in addition to anti-IL4/IL13 antibodies. Read More

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http://dx.doi.org/10.1016/S0151-9638(18)31289-4DOI Listing
December 2018
13 Reads

Clinicopathologic retrospective analysis of annular pustular psoriasis.

Acta Dermatovenerol Alp Pannonica Adriat 2018 Dec;27(4):215-219

Department of Dermatology, Sexually Transmitted Diseases, and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Annular pustular psoriasis (APP) is a rare form of pustular psoriasis with a chronic relapsing course and a good prognosis. The clinical picture is characterized by erythematous lesions, usually polycyclic, with the presence of small, sterile pustules on the circumference of the lesions and fine peeling. We present two cases of APP with diagnostic problems: a 65-year-old woman that suffered from intermittent APP with remission and exacerbation for many years, and an 83-year-old man with lesions that developed after atenolol treatment. Read More

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December 2018
2 Reads

Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis.

J Dermatol 2019 Feb 14;46(2):144-148. Epub 2018 Dec 14.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Pustulotic arthro-osteitis, occasionally complicated with palmoplantar pustulosis, affects patients' activities of daily living. Granulocyte and monocyte adsorption apheresis selectively removes activated granulocytes and monocytes by means of extracorporeal circulation. Although the efficacy of granulocyte and monocyte adsorption apheresis in the treatment of generalized pustular psoriasis has been proved, very few reports have assessed its efficacy in the treatment of palmoplantar pustulosis and pustulotic arthro-osteitis. Read More

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http://dx.doi.org/10.1111/1346-8138.14717DOI Listing
February 2019
12 Reads

Secukinumab in Generalized Pustular Psoriasis.

Indian Dermatol Online J 2018 Nov-Dec;9(6):464-466

Consultant Dermatologist, Apollo Hospitals, Greams Road, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_93_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233001PMC
December 2018
10 Reads

Generalized pustular psoriasis complicated with bullous pemphigoid.

Int J Dermatol 2019 Mar 5;58(3):e66-e67. Epub 2018 Dec 5.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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http://dx.doi.org/10.1111/ijd.14332DOI Listing
March 2019
6 Reads

Palmar pustular psoriasis associated with teriflunomide treatment.

Mult Scler Relat Disord 2019 Jan 19;27:400-402. Epub 2018 Nov 19.

Neuroimmunology service, FLENI, Montañeses 2325, (1428), Buenos Aires, Argentina.

Background: Cutaneous adverse effects of Teriflunomide have been rarely reported.

Objective And Methods: We report a relapsing remitting multiple sclerosis patient that developed palmar pustular psoriasis within one month of teriflunomide initiation.

Results: Our patient required discontinuation of teriflunomide due to frequent recurrence of pustules with continuous need of local steroid treatment and resolved completely after teriflunomide discontinuation. Read More

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http://dx.doi.org/10.1016/j.msard.2018.11.020DOI Listing
January 2019
2 Reads

Chronic recurrent multifocal osteomyelitis with psoriatic skin manifestations in a 12-year-old female.

Dermatol Pract Concept 2018 Oct 31;8(4):297-298. Epub 2018 Oct 31.

Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany.

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http://dx.doi.org/10.5826/dpc.0804a09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246070PMC
October 2018
3 Reads

Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation.

J Dermatol 2019 Jan 26;46(1):73-75. Epub 2018 Nov 26.

Departments of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.

Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that presents with erythema and sterile pustules, pathologically characterized by Kogoj's spongiform pustules. GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue. IL36RN mutation was found to contribute to the pathogenesis of GPP especially in patients who develop GPP without a past medical history of psoriasis vulgaris. Read More

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http://dx.doi.org/10.1111/1346-8138.14711DOI Listing
January 2019
14 Reads

Investigation of Psoriasis Susceptibility Loci in Psoriatic Arthritis and a Generalized Pustular Psoriasis Cohort.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S83-S85

Department of Dermatology, Huashan Hospital, Fudan University, Huashan Hospital, Shanghai, People's Republic of China. Electronic address:

Psoriasis is a common skin disease affecting 1-3% of the population (Gelfand et al., 2005; Ferrándiz et al., 2001). Read More

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http://dx.doi.org/10.1016/j.jisp.2018.09.008DOI Listing
December 2018
4 Reads

Successful therapy with secukinumab in a patient with generalized pustular psoriasis carrying homozygous IL36RN p.His32Arg mutation.

Int J Dermatol 2019 Jan 14;58(1):e16-e17. Epub 2018 Nov 14.

Department of Dermatology, University Hospital of Tours, University François-Rabelais, Tours, France.

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http://doi.wiley.com/10.1111/ijd.14293
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http://dx.doi.org/10.1111/ijd.14293DOI Listing
January 2019
24 Reads

IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis.

Exp Dermatol 2019 Feb 21;28(2):113-120. Epub 2018 Dec 21.

Dermatology Discovery, AbbVie Inc., North Chicago, Illinois.

Psoriasis vulgaris (PV) results from activation of IL-23/Th17 immune pathway and is further amplified by cytokines/chemokines from skin cells. Among skin-derived pro-inflammatory cytokines, IL-36 family members are highly upregulated in PV patients and play a critical role in general pustular psoriasis. However, there is limited data showing crosstalk between the IL-23 and IL-36 pathways in PV. Read More

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http://doi.wiley.com/10.1111/exd.13841
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http://dx.doi.org/10.1111/exd.13841DOI Listing
February 2019
6 Reads

Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis.

J Invest Dermatol 2019 Apr 2;139(4):848-858. Epub 2018 Nov 2.

Department of Dermatology, University Hospital, Zürich, Switzerland; Faculty of Medicine, University of Zürich, Zürich, Switzerland. Electronic address:

Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous drug reaction. Although an involvement of drug-specific T cells has been reported, the physiopathology of AGEP and mechanism of neutrophilic skin inflammation remain incompletely understood. Recently, mutations in IL-36RN, the gene encoding the IL-36 receptor antagonist, have been reported to be more frequent in AGEP patients and pustular psoriasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183277
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http://dx.doi.org/10.1016/j.jid.2018.10.023DOI Listing
April 2019
13 Reads

Variants of CARD14 are predisposing factors for generalized pustular psoriasis (GPP) with psoriasis vulgaris but not for GPP alone in a Chinese population.

Br J Dermatol 2019 Feb 29;180(2):425-426. Epub 2018 Nov 29.

Shandong Provincial Hospital for Skin Diseases, Jinan, Shandong, China.

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http://doi.wiley.com/10.1111/bjd.17392
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http://dx.doi.org/10.1111/bjd.17392DOI Listing
February 2019
7 Reads

[Genetic Polymorphism of IL36RN in Han Patients with Generalized Pustular Psoriasis Alone in Sichuan Region].

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Jul;49(4):582-586

Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To detect interleukin-36-receptor antagonist gene in Han patients with generalized pustular psoriasis (GPP) alone in Sichuan region for the purpose of clarification of GPP pathogenesis.

Methods: Genomic DNA of GPP patients, psoriasis vulgaris (PV) patients and normal controls was extracted and subjected to PCR for the amplification of entire encoding and splice sites of gene followed by bidirectional sequencing. Differences in frequencies of variants between three groups were analyzed. Read More

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July 2018
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Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis.

Dermatol Ther (Heidelb) 2018 Dec 20;8(4):593-604. Epub 2018 Oct 20.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Introduction: Psoriatic arthritis (PsA) is a chronic, inflammatory arthritis that affects an estimated 30% of patients with psoriasis. PsA is underdiagnosed in primary care and dermatology clinics due to a variety of reasons, including failure of healthcare providers to ask about symptoms, overlap of symptoms and signs with other rheumatologic conditions, and lack of a specific diagnostic test. A delay in PsA diagnosis and treatment, even as short as 6 months, can lead to decreased quality of life, increased joint damage, and worse long-term physical function. Read More

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http://link.springer.com/10.1007/s13555-018-0266-x
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http://dx.doi.org/10.1007/s13555-018-0266-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261122PMC
December 2018
17 Reads

Long-term efficacy and safety of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis: subgroup analyses of an open-label, phase 3 study (UNCOVER-J).

J Eur Acad Dermatol Venereol 2019 Feb 15;33(2):325-332. Epub 2018 Nov 15.

Eli Lilly Japan K.K., Kobe, Japan.

Background: Erythrodermic and generalized pustular psoriasis are rare, difficult to treat forms of psoriasis. In previous reports, we documented 24- and 52-week findings of an open-label, phase 3 trial (UNCOVER-J) of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis; most patients responded to treatment and maintained response through 52 weeks.

Objective: To assess the long-term (>3 years) efficacy and safety of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis. Read More

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http://doi.wiley.com/10.1111/jdv.15287
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http://dx.doi.org/10.1111/jdv.15287DOI Listing
February 2019
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Adalimumab treatment in Japanese patients with generalized pustular psoriasis: Results of an open-label phase 3 study.

J Dermatol 2018 Dec 10;45(12):1371-1380. Epub 2018 Oct 10.

AbbVie G.K., Tokyo, Japan.

A phase 3, multicenter, open-label, 52-week study investigated the efficacy and safety of adalimumab 80 mg at week 0 followed by adalimumab 40 mg every other week (option to escalate to 80 mg when necessary) in Japanese patients with generalized pustular psoriasis (GPP). Adults (aged 15-75 years) with GPP, total skin score (overall erythema area, erythema area with pustules, and edema area) of 3 or more, and erythema with pustules (skin score, ≥1) based on the 2014 Japanese Dermatological Association severity index of GPP were enrolled. The primary efficacy end-point was clinical response at week 16 (non-responder imputation), defined as achieving remission (total skin score, 0) or improvement from baseline (reduction of ≥1 point from a baseline total skin score of 3 or ≥2 points from a baseline total skin score of ≥4). Read More

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http://doi.wiley.com/10.1111/1346-8138.14664
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http://dx.doi.org/10.1111/1346-8138.14664DOI Listing
December 2018
13 Reads

Treatment of pustular psoriasis with anakinra: a statistical analysis plan for stage 1 of an adaptive two-staged randomised placebo-controlled trial.

Trials 2018 Oct 3;19(1):534. Epub 2018 Oct 3.

Imperial Clinical Trials Unit, School of Public Health, Imperial College London, Stadium House, 68 Wood Lane, London, W12 7RH, UK.

Background: Palmoplantar pustulosis (PPP) is a rare, chronic inflammatory skin disease. It is known to affect quality of life at a level comparable to that from major medical and psychiatric illness, yet current treatment options are remarkably limited. Recent evidence however suggests that interleukin-1 (IL-1) blockade with anakinra will deliver therapeutic benefit in PPP. Read More

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http://dx.doi.org/10.1186/s13063-018-2914-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169096PMC
October 2018
7 Reads

A cross-sectional study of the distribution of psoriasis subtypes in different ethno-racial groups.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

Department of Dermatology, University of California-San Francisco, San Francisco, California.

Skin of colored patients with psoriasis are more likely to remain undiagnosed and experience a greater impact on quality of life than their white counterparts. A better understanding of the ethno-racial differences in the presentation of psoriasis can help address these disparities. To compare the prevalence of psoriatic subtypes (plaque, guttate, pustular, erythrodermic, palmoplantar, and inverse) and lesion locations in Caucasian, Asian, and Hispanic/Latino patients, we analyzed cross-sectional, patient-reported, physician-reviewed survey data from 882 adult and 16 pediatric psoriasis patients seen at the University of California, San Francisco Department of Dermatology between 2006 and 2016. Read More

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July 2018
23 Reads