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    1 OF 30

    Pediatric pustular psoriasis responsive to cyclosporine bridged to etanercept: A treatment approach.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    New York Presbyterian/Weill Cornell Medical College, New York.
    Pustular psoriasis occurs rarely in children but can present with acute toxicity requiring inpatient admission. For the best approach, medical providers should have an evidence based and systematic treatment algorithm in their armamentarium. Toillustrate this point, we describe a 13-year-old girl who was admitted with generalized pustular psoriasis and who responded dramatically to "wet wrap" therapy and cyclosporine bridged to etanercept. Read More

    RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature.
    Front Immunol 2018 29;9:80. Epub 2018 Jan 29.
    Department of Dermatology, University of Michigan, Ann Arbor, MI, United States.
    IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, or IL-36G. We identified some early IL-1B-specific responses (8 h posttreatment), but nearly all late IL-1B responses were replicated by IL-36 cytokines (24 h posttreatment). Read More

    Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report.
    Case Rep Dermatol 2017 Sep-Dec;9(3):259-264. Epub 2017 Dec 18.
    Department of Dermatology, King Saud University Medical City, Riyadh, Saudi Arabia.
    Acrodermatitis continua of Hallopeau (ACH) is an uncommon inflammatory disease manifesting as sterile pustular eruption of the fingers and toes. The disease is of a chronic relapsing nature and is often refractory to treatment. With longstanding disease, osteitis with consequent bone resorption of the underlying phalanges can occur, leading to disability. Read More

    Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.
    J Dermatol Sci 2018 Feb 1. Epub 2018 Feb 1.
    Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
    Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More

    ARDS complicating pustular psoriasis: treatment with low-dose corticosteroids, vitamin C and thiamine.
    BMJ Case Rep 2018 Feb 2;2018. Epub 2018 Feb 2.
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.
    We report the case of a 45-year-old Caucasian woman with a history of psoriasis, admitted to our Medical intensive care unit following the acute onset of diffuse rash and progressive dyspnoea and hypoxaemia requiring escalating respiratory support (continuous positive airway pressure of 10 cm HO). Her chest X-ray was consistent with findings of non-cardiogenic pulmonary oedema. Echocardiogram was normal. Read More

    Comparison of effectiveness and safety of excimer lamp versus topical calcipotriol-clobetasol propionate combination in the treatment of palmoplantar psoriasis.
    Photodermatol Photoimmunol Photomed 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
    Background: Very few studies have assessed the efficacy of excimer treatment in palmoplantar psoriasis (PPP), and none has compared the excimer with calcipotriol-clobetasol combination.

    Purpose: To compare the effectiveness and safety of excimer lamp versus topical ointment containing calcipotriol (0.005% w/w) and clobetasol propionate (0. Read More

    Increased levels of lipocalin 2 in palmoplantar pustular psoriasis.
    J Dermatol Sci 2018 Jan 11. Epub 2018 Jan 11.
    Psoriasis Research and Treatment Centre, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
    Background: Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles.

    Objective: To identify and characterize pathogenetic players in PPP.

    Methods: Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Read More

    Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management.
    Psoriasis (Auckl) 2017 16;7:51-63. Epub 2017 Oct 16.
    Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.
    Psoriasis is the skin disease that most frequently affects the nails. Depending on the very nail structure involved, different clinical nail alterations can be observed. Irritation of the apical matrix results in psoriatic pits, mid-matrix involvement may cause leukonychia, whole matrix affection may lead to red lunulae or severe nail dystrophy, nail bed involvement may cause salmon spots, subungual hyperkeratosis, and splinter hemorrhages, and psoriasis of the distal nail bed and hyponychium causes onycholysis whereas that of the proximal nail fold causes psoriatic paronychia. Read More


    How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?
    An Bras Dermatol 2017 Nov-Dec;92(6):826-829
    Department of Dermatology, Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.
    Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. Read More

    Psoriasis: from Pathogenesis to Targeted Therapies.
    Clin Rev Allergy Immunol 2018 Feb;54(1):102-113
    Department of Dermatology, Lausanne University Hospital CHUV, Lausanne, Switzerland.
    Over the last decade, the management of psoriasis has witnessed a paradigm shift. Thanks to the increasing knowledge about the pathogenesis of psoriasis, targeted treatments with monoclonal antibodies have been developed. These antibodies, which target the pathogenic TNF/IL-23/IL-17-pathway, were shown to be safe and efficacious in the management of most patients with moderate to severe chronic plaque psoriasis. Read More

    Secukinumab: a review of the anti-IL-17A biologic for the treatment of psoriasis.
    Ther Adv Chronic Dis 2018 Jan 16;9(1):5-21. Epub 2017 Nov 16.
    Baylor Scott and White- Division of Dermatology, 3900 Junius Street, Suite 125, Dallas, TX 75246, USA.
    Psoriasis is a systemic inflammatory disease associated with numerous comorbidities and a profound impact on patients' quality of life. While its complex immune pathogenesis is still not fully delineated, current evidence supports a fundamental role of the T-helper-17 (TH-17) pathway and its related interleukin-17 (IL-17) cytokine. Thus, new antipsoriatic therapies have been developed to block this key cytokine and its downstream effects. Read More

    Comparison of guidelines for the use of TNF inhibitors for psoriasis in the United States, Canada, Europe and the United Kingdom: a critical appraisal and comprehensive review.
    J Dermatolog Treat 2018 Feb 2:1-7. Epub 2018 Feb 2.
    c Kaiser Permanente Los Angeles Medical Center Department of Dermatology , Los Angeles , CA , USA.
    Purpose: To compare and contrast evidence-based CPGs from leading dermatological organizations for the use of tumor necrosis factor inhibitors (TNFi) in psoriasis.

    Materials And Methods: Guidelines from the British National Institute for Health and Care Excellence (NICE), the British Association of Dermatologists (BAD), the American Academy of Dermatology (AAD), the National Psoriasis Foundation (NPF), and the Canadian Dermatology Association (CDA) were reviewed and compared.

    Results: Various guidelines are similar regarding treatment initiation but have significant differences regarding topics such as continuous versus intermittent therapy, use in erythrodermic and pustular palmoplantar psoriasis and special patient populations. Read More

    Pustular psoriasis and related pustular skin diseases.
    Br J Dermatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Dermatology, AP-HP Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris CEDEX 10, 75475, France.
    Patients with pustular psoriasis or related pustular diseases may have genetic abnormalities impairing the function of key players of the innate skin immune system. Recently, identification of these abnormalities has changed the paradigm of several of these diseases. These include generalized pustular psoriasis, palmoplantar pustular psoriasis and acrodermatitis continua of Hallopeau, and also drug-induced acute exanthematous generalized pustular eruption. Read More

    Evaluation of ICAM-1 expression and vascular changes in the skin of patients with plaque, pustular, and erythrodermic psoriasis.
    Int J Dermatol 2018 Feb 10;57(2):209-216. Epub 2018 Jan 10.
    Sector of Dermatology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
    Background: Psoriasis is a chronic inflammatory disease. Pustular, erythrodermic, and extensive plaque psoriasis are responsible for systemic complications. Systemic capillary leak syndrome is the complication with greater progression to death and occurs due to vascular changes. Read More

    Unopposed IL-36 activity promotes clonal CD4T-cell responses with IL-17A production in generalized pustular psoriasis.
    J Invest Dermatol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Dermatology and Allergology, University Hospital, Ludwig-Maximilian-University, D-80337 Munich, Germany. Electronic address:
    Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory aetiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signalling promotes antigen-driven and likely pathogenic T-helper 17 (Th17) responses in GPP. Read More

    Pemphigus foliaceus with pustular presentation in a patient with psoriasis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):115-117
    Dermatology Department at Hospital Universitário Pedro Ernesto, of the Universidade do Estado do Rio de Janeiro (Hupe-Uerj) - Rio de Janeiro (RJ), Brazil.
    Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. Read More

    Histopathological aspects of psoriasis and its uncommon variants.
    G Ital Dermatol Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
    Psoriasis is a chronic complex multisystem, inflammatory, skin disorder that causes vasodilatation and hyperproliferation of keratinocytes, whose clinical expression includes a thickened, erythematous skin, often covered with silver grey scales. Psoriasis is a unique disease where both autoimmune and autoinflammatory responses coexist and the balance between the two components is essential in determining its clinical and histopathological presentation. Adaptive immune responses prevail in chronic plaque psoriasis while innate and autoinflammatory responses predominate in pustular psoriasis. Read More

    Immunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions.
    J Immunol Res 2017 31;2017:6928363. Epub 2017 Oct 31.
    Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
    Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Read More

    Generalized pustular psoriasis in a 92-year-old man with a homozygous nonsense mutation in IL36RN.
    J Dermatol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Dermatology, Jichi Medical University, Shimotsuke, Japan.
    A 92-year-old man developed an erythematous eruption on the trunk and extremities with numerous pustules accompanied by fever. He had never experienced pustular eruption or been diagnosed with psoriasis previously. Skin biopsy revealed Kogoj's spongiform pustule, and he was diagnosed with generalized pustular psoriasis (GPP). Read More

    Clinical features of von Zumbusch type of generalized pustular psoriasis in children: a retrospective study of 26 patients in southwestern China.
    An Bras Dermatol 2017 May-Jun;92(3):319-322
    The Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital - Chengdu, China.
    Background: Von Zumbusch type of generalized pustular psoriasis is a rare variant of psoriasis in children. It can occur in patients with or without psoriasis vulgaris.

    Objective: The aim of the study was to discuss the precipitating factors, clinical manifestations, laboratory data and therapy of von Zumbusch type of generalized pustular psoriasis in children from southwestern China and to improve the diagnosis and treatment level. Read More

    Abrupt generalized pustules in patients with rheumatoid arthritis and interstitial lung disease.
    J Dermatol 2018 Feb 23;45(2):198-201. Epub 2017 Nov 23.
    Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
    We report a case of a 30-year-old Chinese woman with rheumatoid arthritis and interstitial lung disease who abruptly developed generalized pustules and a high fever for 10 days. She had been taking oral prednisone, iguratimod and total glucosides of peony regularly for 5 months prior. In addition, she had taken metronidazole for 3 days 20 days prior which she had used before with no adverse reaction. Read More

    The Efficacy of Biologic Therapy for the Management of Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review.
    Dermatol Ther (Heidelb) 2017 Dec 15;7(4):425-446. Epub 2017 Nov 15.
    Department of Dermatology, University of California San Francisco, San Francisco, USA.
    Introduction: Palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) are diseases affecting the hands and/or feet that can cause marked physical discomfort and functional disability. The tumor necrosis factor-alpha antagonists adalimumab, etanercept, and infliximab, the interleukin (IL)-17A inhibitors ixekizumab and secukinumab, and the IL-23 or IL-12/IL-23 inhibitors guselkumab and ustekinumab have been well studied for the treatment of moderate to severe plaque psoriasis. Less is known about the efficacy and safety of these agents for the treatment of PP (hyperkeratotic and pustular forms) and PPP. Read More

    Paradoxical Reactions: Anti-Tumor Necrosis Factor Alpha Agents, Ustekinumab, Secukinumab, Ixekizumab, and Others.
    Curr Probl Dermatol 2018 7;53:49-63. Epub 2017 Nov 7.
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease. Paradoxical reactions have subsequently been reported with other biological drugs or classes (e. Read More

    Epidemiological survey from 2009 to 2012 of psoriatic patients in Japanese Society for Psoriasis Research.
    J Dermatol 2017 Nov 8. Epub 2017 Nov 8.
    Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
    Since 1982, the Japanese Society for Psoriasis Research has conducted annual epidemiological surveys of patients with psoriasis. Kawada et al. have reported data for 1982-2001 and Takahashi et al. Read More

    Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review.
    J Dermatolog Treat 2017 Nov 9:1-11. Epub 2017 Nov 9.
    c Institute of Dermatology , Guangzhou Medical University , Guangzhou , P.R. China.
    Background: There is a few evidence-based information regarding the efficacy and safety of acitretin treatment in children with pustular psoriasis (PP).

    Objective: This study aimed to provide an additional evidence for this field.

    Methods: A retrospective study was undertaken for 15 children with PP who received acitretin in doses of 0. Read More

    A mysterious abdominal pain during active psoriasis.
    Intern Emerg Med 2017 Oct 30. Epub 2017 Oct 30.
    Dipartimento di Fisiopatologia Medico-Chirurgica E dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, IRCCS Fondazione Ca' Granda, Ospedale maggiore Policlinico, via Pace 9, 24125, Milan, Italy.

    The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: Immunophenotyping and response to ustekinumab.
    J Am Acad Dermatol 2018 Mar 21;78(3):498-505.e2. Epub 2017 Oct 21.
    Department of Dermatology, Mount Sinai School of Medicine, New York, New York.
    Background: The immune abnormalities underlying the ichthyoses are poorly understood.

    Objective: To determine the immunophenotype of an ichthyosis resulting from mutations in the spectrin repeat 6 (SR6) domain of desmoplakin gene (DSP) and target therapy on the basis of molecular pathogenesis.

    Methods: Immunophenotyping was performed by using the blood and skin of a girl with SR6 region DSP mutations causing erythroderma/ichthyosis and cardiomyopathy. Read More

    Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan.
    J Dermatol 2017 Oct 19. Epub 2017 Oct 19.
    Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
    A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28. Read More

    Generalized pustular psoriasis triggered by Zika virus infection.
    Clin Exp Dermatol 2018 Mar 13;43(2):171-174. Epub 2017 Oct 13.
    Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia.
    Zika virus is an emerging arbovirus, which is expanding in epidemic proportions through tropical and subtropical areas of the world. Although Zika is linked to a number of congenital and neurological complications, there is scarce knowledge on the impact of ZIKV infection in human skin. We report the case of a 68-year old woman who presented with generalized pustular psoriasis after a preceding and otherwise uneventful episode of ZIKV infection. Read More

    TNFα and IL-17A are differentially expressed in psoriasis-like vs eczema-like drug reactions to TNFα antagonists.
    J Cutan Pathol 2018 Jan 22;45(1):23-28. Epub 2017 Nov 22.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Background: Tumor necrosis factor α (TNFα) blocking drugs are in use for a wide range of autoimmune disorders. In up to 5% of patients, this class of drugs produces puzzling cutaneous side effects that are the subject of this investigation, namely psoriasiform and eczema-like skin inflammation. These side effects can occur after any time of treatment and regardless of the underlying disorders. Read More

    Intracorneal pustular drug eruption, a novel cutaneous adverse event in anti-programmed cell death-1 patients that highlights the effect of anti-programmed cell death-1 in neutrophils.
    Melanoma Res 2017 Dec;27(6):641-644
    aDepartment of Dermatology bDepartment of Pathology, Institute for Clinical Pathology and Medical Research, Westmead Hospital cDepartment of Dermatology, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.
    The introduction of anti-programmed cell death-1 (anti-PD1) monoclonal antibodies has revolutionized the treatment of various advanced malignancies. Despite its efficacy, anti-PD1 therapy is accompanied by a variety of cutaneous adverse events. A 79-year-old man developed erythematous scaly plaques and pustules of the forehead, legs and arms after four cycles of nivolumab infusions every 2 weeks. Read More

    Cutaneous Manifestations of Chikungunya Fever: Observations from an Outbreak at a Tertiary Care Hospital in Southeast Rajasthan, India.
    Indian Dermatol Online J 2017 Sep-Oct;8(5):336-342
    Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
    Background: Chikungunya fever is caused by chikungunya virus which is transmitted by the bite of infectedandmosquitoes.

    Aims: To study the various mucocutaneous manifestations in suspected cases of chikungunya fever.

    Materials And Methods: The patients who attended our outpatient department from July 2016 to October 2016 and fulfilled the criteria for "suspect cases" of chikungunya infection stipulated by the National Institute of Communicable Diseases, Directorate General of Health Services, Government of India, were included in the study prospectively. Read More

    Recurrent impetigo herpetiformis: case report.
    Pan Afr Med J 2017 24;27:219. Epub 2017 Jul 24.
    Faculty of Health Sciences, Egerton University, Njoro, Kenya.
    Impetigo herpetiformis (pustular psoriasis of pregnancy) is a rare dermatosis of pregnancy that typically starts in the 2half of pregnancy and resolves postpartum. It may recur in subsequent pregnancies. I present a case of 23 year old female gravida 4 para 3 with recurrent impetigo herpetiformis at 26 weeks gestation. Read More

    Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis.
    Acta Derm Venereol 2018 Jan;98(1):5-13
    Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka, 812-8582, Japan.
    Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. Read More

    The genetic basis for most patients with pustular skin disease remains elusive.
    Br J Dermatol 2017 Aug 5. Epub 2017 Aug 5.
    Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
    Background: Rare variants in the genes IL36RN, CARD14 and AP1S3 have been identified to cause or contribute to pustular skin diseases, primarily generalized pustular psoriasis (GPP).

    Objectives: To better understand the disease relevance of these genes, we screened our cohorts of patients with pustular skin diseases [primarily GPP and palmoplantar pustular psoriasis (PPP)] for coding changes in these three genes. Carriers of single heterozygous IL36RN mutations were screened for a second mutation in IL36RN. Read More

    Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization.
    Acta Derm Venereol 2018 Jan;98(1):50-58
    Department of Dermatology and Venereology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, DE-39120 Magdeburg, Germany.
    Differential diagnosis of palmoplantar non-pustular psoriasis and chronic allergic contact dermatitis (ACD) and the combination of these conditions, termed "eczema in psoriatico" (EIP), is difficult, especially in cases of isolated involvement. A blind re-evaluation of 63 archived formalin-fixed palmoplantar samples, previously diagnosed clinically as either psoriasis or chronic ACD, was performed. Samples were allocated to histopathological diagnoses of psoriasis, contact dermatitis or EIP. Read More

    Pustular Palmoplantar Psoriasis Successfully Treated with Nb-UVB Monochromatic Excimer Light: A Case-Report.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):462-466. Epub 2017 Jul 19.
    Universitario di Ruolo, Dipartimento di Scienze Dermatologiche, Università degli Studi di Firenze, Facoltà di Medicina e Chirurgia, Dermatology, Via Vittoria Colonna 11, Rome 00186, Italy.
    Barber's palmoplantar pustulosis (PPP) is a form of localised pustular psoriasis, affecting the palmar and plantar surfaces. It is a chronic disease, with a deep impact on the patients' quality of life. The Authors discuss a case of Baber Psoriasis successfully treated with monochromatic excimer light. Read More

    Acute generalized exanthematous pustulosis and polyarthritis associated with a novel CARD14 mutation.
    Australas J Dermatol 2018 Feb 3;59(1):e70-e73. Epub 2017 Aug 3.
    Department of Dermatology, Hospital Clinic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
    Acute generalised exanthematous pustulosis (AGEP) is a rare toxicoderma characterised by an acute onset rash, with many sterile pustules on the surface, high fever and increased acute phase reactants. We report the case of a patient who presented to the dermatology department with an AGEP and polyarthritis, in which a novel CARD14 mutation was identified. The pathophysiological mechanism of AGEP remains unclear, although mutations in the IL36RN gene have been identified in a small subset of AGEP patients. Read More

    Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides.
    Clin Rev Allergy Immunol 2017 Dec;53(3):371-393
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients. Several cutaneous manifestations have been related to rheumatoid arthritis such as subcutaneous nodules including classical rheumatoid nodules, accelerated rheumatoid nodulosis, and rheumatoid nodulosis; vascular disorders like rheumatoid vasculitis, livedo racemosa, and Raynaud's phenomenon; and neutrophilic and/or granulomatous diseases like pyoderma gangrenosum, Sweet's syndrome, rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with arthritis, as well as palisaded neutrophilic and granulomatous dermatitis. Read More

    Autoinflammatory diseases in dermatology: DITRA and CAMPS.
    Nihon Rinsho Meneki Gakkai Kaishi 2017 ;40(3):169-173
    Department of Dermatology, Fujita Health University School of Medicine.
    Deficiency of interleukin thirty-six receptor antagonist (DITRA) and CARD14 mediated psoriasis (CAMPS) are autoinflammatory diseases in dermatology. The causative genes of DITRA and CMAPS have been identified recently. In this paper, IL36RN and CARD14, the causative gene for DITRA and CAMPS, respectively were explained. Read More

    Psoriasis: a mixed autoimmune and autoinflammatory disease.
    Curr Opin Immunol 2017 Dec 22;49:1-8. Epub 2017 Jul 22.
    Department of Dermatology, University of Michigan, 1910 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:
    In recent years marked progress has been made in our understanding of the critical biologic and immunologic pathways involved in psoriasis. Genetic studies have demonstrated that susceptibility to psoriasis involves components of both the adaptive and innate immune system and not surprisingly activation of both of these arms of the immune system is found in psoriatic skin. While adaptive immune responses predominate in chronic plaque psoriasis, innate and autoinflammatory responses dominate in pustular forms of psoriasis, with other clinical subtypes extending on a spectrum between plaque and pustular psoriasis. Read More

    Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.
    MAbs 2017 Oct 20;9(7):1143-1154. Epub 2017 Jul 20.
    a Boehringer Ingelheim Pharmaceuticals Inc. , Ridgefield , CT ., USA.
    Deficiency of interleukin (IL)-36 receptor antagonist (DITRA) syndrome is a rare autosomal recessive disease caused by mutations in IL36RN. IL-36R is a cell surface receptor and a member of the IL1R family that is involved in inflammatory responses triggered in skin and other epithelial tissues. Accumulating evidence suggests that IL-36R signaling may play a role in the pathogenesis of psoriasis. Read More

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