Search Our Scientific Publications & Authors

Cureus 2021 May 8;13(5):e14907. Epub 2021 May 8.

Dermatology, King Abdulaziz Medical City, Jeddah, SAU.

Background: Psoriasis is a chronic, inflammatory, and immune-mediated dermatological disease of unknown etiology with predominant involvement of the skin, nails, and joints. This study aimed to assess comorbidities patterns in psoriasis patients.

Methods: This is a cross-sectional study conducted at King Abdulaziz Medical City (KAMC) in Jeddah, Saudi Arabia. Read More

J Clin Med 2021 May 14;10(10). Epub 2021 May 14.

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.

The study aimed to evaluate the effect of retinoid treatment on the morphological changes in the nail apparatus in patients with nail psoriasis.

Material And Methods: 41 patients aged 32 to 64 with nail psoriasis, without clinical signs of psoriatic arthritis, started on acitretin 0.6 to 0. Read More

Mycoses 2021 Jun 1. Epub 2021 Jun 1.

Federal University of Rio de janeiro, Medical Clinics Department, Post graduation Course, Sector of Dermatology, Rio de Janeiro, Brazil.

Background: Epidemiological studies indicate that onychomycosis may affect up to 79% of psoriatic patients. Onychomycosis in psoriatic patients is more commonly caused by yeasts comparing with non-psoriatic.

Objectives: Evaluate the prevalence of fungi in nail psoriasis. Read More

Dermatol Ther (Heidelb) 2021 Jun 12;11(3):799-831. Epub 2021 May 12.

Department of Dermatology, Psoriasis and Skin Treatment Center, University of California San Francisco, 515 Spruce Street, San Francisco, CA, 94118, USA.

Nail psoriasis has a prevalence that ranges from 10 to 82% and can significantly impact the quality of life of patients. Nail psoriasis is one of the most challenging areas to treat, and multiple therapies have been explored. Topical and injectable therapies are recommended for few-nail disease. Read More

J Dermatol 2021 Jun 24;48(6):894-901. Epub 2021 Apr 24.

Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Dermoscopy is an efficient and non-invasive technique which has been widely used in the diagnosis of nail disorders including nail psoriasis (NP). Many nail dermoscopic features are considered as clues to NP. The aim of this study was to investigate specific dermoscopic features of fingernail psoriasis and the correlation between the severity of nail lesions or systemic inflammation, and psoriasis severity of skin and nail. Read More

Dermatol Surg 2021 Apr;47(4):e111-e116

Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Nail psoriasis is a common and potentially debilitating condition for which no effective and safe nonsystemic therapy is currently available. Recently, laser-assisted drug delivery (LADD) is being increasingly used to facilitate transcutaneous penetration of topical treatments.

Objectives: We set to assess the efficacy and safety of combined pulse-dye laser and fractional CO2 laser-assisted betamethasonecalcipotriol gel delivery for the treatment of nail psoriasis. Read More

J Med Radiat Sci 2021 Apr 1. Epub 2021 Apr 1.

Radiation Therapy, Townsville Cancer Centre, Townsville Hospital and Health Service, Townsville, Queensland, Australia.

Psoriasis is an inflammatory autoimmune disease of the skin and nails, causing debilitating pain and having an adverse effect on the patients' life. Typical treatment regimens involve topical and systemic therapies in combination with phototherapy. However, patients with extensive, chronic disease may encounter treatment resistance, with limited or no success of these therapies. Read More

Dermatol Clin 2021 Apr 11;39(2):211-220. Epub 2021 Feb 11.

University Hospital of Venereal and Skin Diseases "A.Sygros", 5, Ionos Dragoumi str, Athens 161 21, Greece.

Nail psoriasis is a chronic nail disorder that requires personalized treatment. General prophylactic measures are suggested for all patients. Topical treatment is considered when treating a few-nail disease, with involvement of 3 or fewer nails, without joint involvement and without (or with mild) skin psoriasis. Read More

Dermatol Clin 2021 Apr 10;39(2):195-210. Epub 2021 Feb 10.

Department of Dermatology, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Psoriasis may affect the skin, scalp, joints, and nails and is common in older adults. Intramatrical injections with triamcinolone acetonide are safe and effective in older individuals. Conventional systemic medications are relatively effective, but side effects, including laboratory abnormalities and drug interactions, are particularly common among older adults. Read More

Dermatol Clin 2021 Apr 11;39(2):183-193. Epub 2021 Feb 11.

Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, New York, NY 10021, USA. Electronic address:

Nail involvement is common in patients with cutaneous psoriasis, which is prevalent among older adults. Nail psoriasis greatly impacts patients' quality of life and self-esteem. Concomitant psoriatic arthritis is common. Read More

J Invest Dermatol 2021 Feb 2. Epub 2021 Feb 2.

Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden; The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, China. Electronic address:

A basis for the genetic predisposition to psoriasis is a single locus, PSORS1, within the major histocompatibility complex I region. This murine major histocompatibility complex locus encodes nonclassical molecules such as Qa2. We hypothesized that a natural loss-of-function variant of Qa2 gene clusters promotes psoriasis. Read More

Rheumatol Adv Pract 2020 11;4(2):rkaa032. Epub 2020 Jul 11.

NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds.

Background: Psoriatic disease (PsD) is a complex systemic disorder with cutaneous and musculoskeletal manifestations. Current evidence on pharmacological interventions, effective across the spectrum of clinical manifestations of early, systemic treatment-naïve PsD, is limited. This review aims to appraise such evidence. Read More

J Clin Aesthet Dermatol 2020 Dec 1;13(12):18-20. Epub 2020 Dec 1.

Dr. Adigun is with the Dermatology & Laser Center of Chapel Hill in Chapel Hill, North Carolina.

Multiple cases have reported onychodystrophy secondary to acrylic nails. We present a case of onychodystrophy with psoriasiform nail changes, including onycholysis, splinter hemorrhages, hyperkeratosis, and nail plate thinning, caused by gel manicures. Histopathological analysis of the nail plate and subungual debris revealed neutrophils in the absence of fungal elements. Read More

J Dermatol 2021 Jun 17;48(6):818-824. Epub 2021 Jan 17.

Department of Dermatology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.

There is a paucity of data focusing on geriatric psoriatic patients. The clinical features were different among those with early-onset psoriasis and elderly-onset psoriasis among the geriatric population. From 2014 to 2018, a total of 290 geriatric psoriatic patients were retrospectively enrolled in our study. Read More

Molecules 2021 Jan 8;26(2). Epub 2021 Jan 8.

Centre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry, 700487 Iași, Romania.

Psoriasis is a chronic inflammatory disease associated with immune system dysfunction that can affect nails, with a negative impact on patient life quality. Usually, nail psoriasis is associated with skin psoriasis and is therefore relatively simple to diagnose. However, up to 10% of nail psoriasis occurs isolated and may be difficult to diagnose by means of current methods (nail biopsy, dermoscopy, video dermoscopy, capillaroscopy, ultrasound of the nails, etc. Read More

Dermatol Online J 2020 Dec 15;26(12). Epub 2020 Dec 15.

Florida Academic Dermatology Centers, Coral Gables, FL Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, FL.

Lichen Planus (LP), the prototype of lichenoid dermatoses, is an idiopathic, T cell-mediated, autoimmune, inflammatory disease. It may affect the skin, hair, nails, and mucous membranes. Many clinical variants of LP have been described, including lichenoid drug eruption or drug induced LP, associated with a myriad of culprit medications. Read More

J Dermatol 2021 Mar 11;48(3):360-365. Epub 2020 Dec 11.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Pathogenesis of palmoplantar pustulosis (PPP) is not fully understood and whether PPP is a variant of plaque psoriasis (PsO) is still controversial. Psoriatic nail changes are among the clinical features common to both diseases, and understanding them could lead to the understanding of the correlation between both diseases. However, only limited numbers of studies have reported nail involvement pattern in PPP. Read More

Cureus 2020 Oct 27;12(10):e11206. Epub 2020 Oct 27.

Dermatology, St. Anthony Hospital, Oklahoma City, USA.

Lichen planus (LP) is a chronic inflammatory disease that affects the skin, hair, nails, and mucous membranes, with variants such as drug-induced lichen planus, which is triggered by medications such as angiotensin-converting enzyme (ACE) inhibitors and antimalarials. Guttate psoriasis (GP), a clinical variant of psoriasis, is associated with streptococcal infections and presents with drop-like papules on the trunk and proximal extremities. In this report, we present a case of LP in an atypical location masquerading as GP and the importance of prompt dermatological referral to improve the patient's quality of life. Read More

Dtsch Med Wochenschr 2020 12 30;145(24):1793-1794. Epub 2020 Nov 30.

Abteilung für Rheumatologie, Immunologie, Osteologie und Physikalische Medizin, Justus-Liebig-Universität Gießen, Campus Kerckhoff, Bad Nauheim.

Arch Dermatol Res 2020 Nov 5. Epub 2020 Nov 5.

Department of Dermatology, University of California, Irvine, Irvine, CA, 92697, USA.

While isotretinoin has been the gold-standard of therapy for severe acne since its approval in 1982, its anti-inflammatory properties makes it a potentially applicable and versatile therapy for a wide variety of dermatologic conditions yet to be explored. This systematic review comprehensively recounts the success of oral isotretinoin in non-acne cutaneous diseases and provide insight into future directions of isotretinoin utility. A systematic literature review was performed using PubMed. Read More

Best Pract Res Clin Rheumatol 2020 12 6;34(6):101594. Epub 2020 Oct 6.

Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Psoriatic arthritis is a heterogenous disease affecting peripheral and axial joints, tendons, ligaments, and their insertions, in addition to the skin and the nails. The complexity of the involved structures has puzzled clinicians trying to understand the underlying pathology that leads to symptoms in order to choose the appropriate medications with different modes of actions. Imaging, mainly ultrasound and magnetic resonance imaging, allows of accurate detection of inflammatory changes in the musculoskeletal structures, which helps to avoid false positive and negative assessments. Read More

Eur J Dermatol 2020 Aug;30(4):362-371

Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, 610041, China.

Background: Nail involvement is common in psoriasis patients, however, there are few detailed studies of clinical parameters related to disease severity and therapeutic efficacy.

Objectives: Our retrospective study aimed to describe the prevalence and clinical characteristics in nail psoriasis patients and determine possible associations between multiple clinical parameters and disease severity or therapeutic efficacy.

Materials And Methods: A total of 89 nail psoriasis patients were included and investigated using dermoscopy. Read More

Indian J Pediatr 2020 Sep 16. Epub 2020 Sep 16.

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Am J Dermatopathol 2020 Dec;42(12):911-915

Laboratoire Central d'Anatomie Pathologique, Hôpital L. Pasteur, University of Nice, Nice, France; and.

To determine whether distal interphalangeal joint psoriatic arthritis (DIP PsA) and nail psoriasis are anatomically linked, we studied 2 fingers taken from a cadaver presenting a typical cutaneous and nail psoriasis in the setting of a dactylitis limited to the fourth toe. This comprehensive study of the inflammatory pattern of DIP PsA is discussed in the context of the controversial theory of the nail as a musculoskeletal appendage. Both the extensor and flexor entheses were focally and quite markedly infiltrated by lymphocytes and showed variable fibrosis and neovascularization. Read More

Br J Dermatol 2021 Jun 25;184(6):1047-1058. Epub 2020 Oct 25.

Probity Medical Research, Inc., Waterloo, ON, Canada.

Background: Significantly more patients with moderate-to-severe plaque psoriasis treated with the interleukin (IL)-17A inhibitor ixekizumab vs. the IL-23p19 inhibitor guselkumab in the IXORA-R head-to-head trial achieved 100% improvement in Psoriasis Area and Severity Index (PASI 100) at week 12.

Objectives: To compare skin and nail clearance and patient-reported outcomes for ixekizumab vs. Read More

J Drugs Dermatol 2020 Aug;19(8):741-746

Background: Presence of nail psoriasis in patients with plaque psoriasis may be an indicator of greater disease severity. Previously, patients with nail psoriasis have had delayed skin clearance after treatment compared to patients without nail psoriasis. Objective: This post-hoc analysis evaluated the efficacy of ixekizumab in clearance of plaque psoriasis in patients with and without nail psoriasis. Read More

Br J Dermatol 2021 01 10;184(1):178-180. Epub 2020 Sep 10.

Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Clin Exp Dermatol 2021 Jan 2;46(1):3-8. Epub 2020 Aug 2.

Department of Dermatology, Gloucestershire Hospitals NHS Foundation Trust, Gloucestershire, UK.

Nail involvement is estimated to affect 80-90% of patients with psoriasis at some point in their lives and is often associated with severe disease. Patients with nail involvement experience pain, functional impairment and social stigma, with significant restriction of daily activities and quality of life. Nail psoriasis is also considered a risk factor for the development of psoriatic arthritis (PsA). Read More

J Dermatolog Treat 2020 Aug 3:1-5. Epub 2020 Aug 3.

Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Purpose: Psoriasis, Psoriatic Arthritis and Nail psoriasis are chronic diseases that share a common underlying etiology of immunity dysregulation, enhanced activation of inflammatory pathways and remitting-relapsing course. Although nails represent a small percentage of the body surface involvement of this site can lead to impaired quality of life, severe discomfort and even result in permanent disability. Current therapeutic options for nail psoriasis include a variety of topical and systemic treatments although they are often reported as unsatisfactory from patients either due to their poor effectiveness or disturbing side effects. Read More

Eur J Dermatol 2020 Jun;30(3):267-278

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, D-20246 HamburgGermany.

Psoriasis may cause considerable disease burden. The involvement of sexually-sensitive/visible body areas has been associated with decreased quality of life (QoL), more depressive symptoms and stigmatisation experiences. To characterise the topical distribution of psoriasis in sexually-sensitive and visible areas, to examine its impact on QoL and to determine which specific patient needs should be addressed in routine care. Read More