Drug Des Devel Ther 2017 30;11:2527-2535. Epub 2017 Aug 30.

Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.

Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Read More

Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.

Department of Dermatology, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 61469, Korea.

Abnormal colouring of the nails may be a sign of underlying systemic or local disorders. This study investigated the prevalence and causes of chromonychia as a whole, as well as of each subtype. Among 163 patients with chromonychia, trauma was the pathogenesis in up to 20. Read More

Actas Dermosifiliogr 2017 Aug 16. Epub 2017 Aug 16.

Servicio de Dermatología, Hospital de Manises, Manises, Valencia, España.

J Drugs Dermatol 2017 Aug;16(8):779-790

Dermatology 2017 Aug 5. Epub 2017 Aug 5.

Department of Experimental, Diagnostic and Specialty Medicine, Università di Bologna, Bologna, Italy.

Introduction: Onychomycosis and nail psoriasis can be embarrassing to patients, so improving the appearance of affected nails should be one of the key short-term goals of treatment.

Methods: An 8-week open-label multicenter study was conducted to assess whether K101-03, a marketed topical treatment containing propylene glycol, glycerol, urea, and lactic acid, could produce rapid cosmetic improvements in affected nails. Adult patients with a big toenail or thumbnail (the "target" nail) affected by onychomycosis (n = 72) or psoriasis (n = 34) or both (n = 1) applied K101-03 to their affected nails once a day for 8 weeks. Read More

Semin Arthritis Rheum 2017 May 11. Epub 2017 May 11.

Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, University Institute Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Fundacion Dr. Pedro M. Catoggio para el Progreso de la Reumatología, Buenos Aires, Argentina. Electronic address:

Objective: It has been shown that nail involvement in psoriasis is associated with systemic enthesopathy. Our objective was to evaluate the association of nail involvement and enthesopathy at distal interphalangeal joint (DIP) level in psoriasis (PsO) and psoriatic arthritis (PsA) patients.

Methods: Consecutive patients (54 PsO and 56 PsA) seen at the outpatients clinic in this cross-sectional study were included. Read More

Turk J Med Sci 2017 Jun 12;47(3):764-770. Epub 2017 Jun 12.

Department of Dermatology, İstanbul Medeniyet University, Göztepe Research and Training Hospital, İstanbul, Turkey.

Background/aim: Thyroid disorders are associated with a wide variety of skin disorders that respond to treatment of hormone imbalance in most cases and thus are of vital importance to dermatologists. This study aimed to evaluate skin findings associated with autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.

Materials And Methods: A total of 300 consecutive patients with either autoimmune (n = 173) or nonautoimmune (n = 127) thyroid disease and 100 healthy control subjects were included in this cross-sectional study. Read More

Case Rep Dermatol 2017 May-Aug;9(2):26-29. Epub 2017 May 22.

aDepartment of Dermatology, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan.

A 42-year-old Japanese man presented with persistent headache during treatment for psoriatic arthritis (PsA) with infliximab. Treatment with infliximab was initiated 3 years before and the psoriatic skin lesions with arthritis were well controlled. However, after 21 doses of infliximab, the skin lesions and joint pain exacerbated and became intractable. Read More

J Eur Acad Dermatol Venereol 2017 Jun 13. Epub 2017 Jun 13.

Argentine Cochrane Center, Institute for Clinical Effectiveness and Health Policy (IECS-CONICET), Buenos Aires, Argentina.

Psoriasis is a chronic inflammatory disease that generally affects the skin, nails and joints. The burden of psoriatic disease in Latin America and the Caribbean (LAC) remains largely unknown. To estimate the burden of psoriasis in LAC. Read More

J Eur Acad Dermatol Venereol 2017 Jun 2. Epub 2017 Jun 2.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Background: Distal interphalangeal (DIP) arthritis is a frequent form of psoriatic arthritis being often linked to nail psoriasis. Modern society is characterized by overuse of smartphones. Indeed, literature has recently focalized on research into smartphone addiction and health-related problems. Read More

J Rheumatol 2017 May;44(5):688-690

From the Division of Rheumatology, and Division of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Musculoskeletal ultrasonography is gaining favor in the evaluation of enthesitis in patients with psoriasis and psoriatic arthritis (PsA). Imaging modalities have shown that the enthesis of the distal interphalangeal joint has a close relationship to the nail itself. Studies have focused on the structure and morphology of nails to determine an association between psoriasis nail changes and the presence or severity of PsA. Read More

AAPS PharmSciTech 2017 Apr 28. Epub 2017 Apr 28.

Department of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS, 38677, USA.

The objective was to prepare a novel nail lacquer formulation to improve the ungual and trans-ungual delivery of apremilast for the potential treatment of nail psoriasis. Nail lacquer formulation was prepared using Eudragit® S 100 as a film-forming polymer and the mixture of ethanol, ethyl acetate, and water as a solvent system. As a result of high-throughput screening studies, dexpanthenol and salicylic acid were found to be the potential penetration enhancers. Read More

Indian J Dermatol 2017 Mar-Apr;62(2):113-122

Department of Dermatology, Dr B. C. Roy Post Graduate Institute of Pediatric Sciences, Kolkata, West Bengal, India.

Psoriasis is resistant to treatment and it shows frequent relapse; systemic treatment is often associated with toxicities, and long-term safety data are lacking for most of the newer drugs like biologics. Moreover, some body areas such as hands, feet, intertriginous areas, scalp, and nails are even more resistant. Frequently, systemic treatments are necessary considering the higher psychological impact on the patient. Read More

Clin Exp Dermatol 2017 Apr 10. Epub 2017 Apr 10.

Department of Dermatology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

Nail psoriasis can be a debilitating condition; however, in patients with isolated nail involvement, the use of toxic systemic therapies such as methotrexate may not be justified. We report on 4 patients (30 involved nails between them), who were treated with injections of methotrexate (0.1 mL of a 25 mg/mL solution) into the nail bed at 3-weekly intervals. Read More

J Dtsch Dermatol Ges 2017 Apr;15(4):405-412

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Patients with nail psoriasis have a higher prevalence of psoriatic arthritis; however, the pathogenetic relationship between these two disorders is as yet unclear. Entheses have been suggested as disease epicenter, which might explain the pathogenesis on an anatomical level.

Objective: To contribute to the elucidation of the hypothesis as regards the anatomical link between nail psoriasis and psoriatic arthritis, with the extensor enthesis of the distal interphalangeal joint as the epicenter. Read More

Skin Appendage Disord 2017 Jan 21;2(3-4):102-108. Epub 2016 Sep 21.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.

Background: Nail psoriasis is a painful and disfiguring nail disease that often leads to invasive biopsies. Dermoscopy of the hyponychium can be useful in the diagnosis showing twisted coiled vessels. Structural features of nail psoriasis have been described with optical coherence tomography (OCT). Read More

An Bras Dermatol 2017 Jan-Feb;92(1):21-25

Department of Rheumatology of the Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) - Porto Alegre (RS), Brazil.

Background:: The nail involvement in psoriasis is related to psoriatic arthritis and may represent a predictor of the disease.

Objectives:: To analyze, through nail clipping, clinically normal and dystrophic nails of patients with cutaneous psoriasis and psoriatic arthritis.

Methods:: This is a cross-sectional multicenter study, conducted between August 2011 and March 2012. Read More

J Dermatol 2017 May 2;44(5):538-541. Epub 2017 Feb 2.

Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.

Although psoriatic nail lesions are small, they cause considerable discomfort for patients and adversely affect quality of life. Few studies have evaluated the dermoscopic features of psoriatic nails. The aim of this study was to clarify the dermoscopic features of nail psoriasis and identify those that reflect psoriatic activity. Read More

Hautarzt 2017 Feb;68(2):153-169

Internistisch-rheumatologische Praxis, München, Deutschland.

Psoriatic arthritis is a chronic inflammatory disease of the musculoskeletal system with association to skin psoriasis and is characterized by variable clinical symptoms with very heterogeneous degrees of disease suffering for patients. Clinical manifestations essentially include alterations to the skin and nails, peripheral arthritis, enthesitis, dactylitis and/or spinal involvement. This variability necessitates an individualized therapy of patients with different therapy targets. Read More

J Eur Acad Dermatol Venereol 2017 May 9;31(5):870-875. Epub 2017 Mar 9.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Introduction: Inequality between age groups has been demonstrated in the prescription of biologics, yet systematic real-world data about age-related differences in psoriasis care are missing.

Objective: To investigate disparities in psoriasis characteristics by age groups and to identify potential impact on psoriasis health care.

Patients And Methods: Data analysis included 3615 patients from the German psoriasis registry PsoBest, which observes adult patients with moderate-to-severe psoriasis or psoriatic arthritis (PsA) on systemic treatment over a time period of 10 years. Read More

J Am Acad Dermatol 2017 Apr 6;76(4):648-654.e2. Epub 2017 Jan 6.

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

Background: Psoriasis vulgaris is characterized by disfiguring and stigmatizing skin lesions. The links among lesions distribution, severity, and stigmatization remain unclear.

Objective: We sought to investigate if the involvement of visible and sensitive areas is linked to stigmatization. Read More

Acta Derm Venereol 2017 05;97(5):644-645

Faculty of Continuing Education, Rīga Stradiņš University, Dzirciema Street 16, LV-1007 Riga, Latvia.

Joint Bone Spine 2016 Dec 5. Epub 2016 Dec 5.

Department of Rheumatology, Brest University Hospital, 29280 Brest, France; Ultrasound Unit Department, Brest University Hospital, 29280 Brest, France. Electronic address:

Objectives: To detect subclinical entheses and nail abnormalities using gray-scale (GS) and power Doppler ultrasonography (PDUS) between patients with nail psoriasis and those with inverse and scalp psoriasis.

Methods: In this prospective monocentric study, patients with nail, inverse and scalp psoriasis, without psoriatic arthritis or systemic treatment, were included. Clinical evaluation and ultrasonographic assessment of 14 entheses and 12 nails were done by a dermatologist (clinical assessment) and a rheumatologist (ultrasonographic assessment). Read More

Expert Rev Clin Immunol 2017 May 2;13(5):439-447. Epub 2016 Dec 2.

a Division of Musculoskeletal and Rheumatic Disorders , Instituto Nacional de Rehabilitación , México City , Mexico.

Introduction: Ultrasound (US) is a rapidly evolving technique that is gaining increasing success in the assessment of psoriatic arthritis (PsA). Recently, new research avenues have been opened, and these are focused on the potential of US for the assessment of extra musculoskeletal areas such as skin and nails. This permits work on the concept of 'holistic US assessment of PsA'. Read More

Pediatr Dermatol 2017 Jan 22;34(1):58-63. Epub 2016 Nov 22.

Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France.

Background/objectives: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis.

Methods: We performed a multicenter, cross-sectional study in 23 French dermatology centers. Read More

Dermatol Pract Concept 2016 Oct 31;6(4):39-42. Epub 2016 Oct 31.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece.

Lichen planus (LP) is an inflammatory disease that affects the skin-mainly the extremities and the trunk-the mucous membranes, the genitalia, the nails and the scalp. The diagnosis of LP is usually established clinically based on the typical morphology and distribution of the lesions in conjunction with the associated itch. We report a patient with LP manifesting highly psoriasiform lesions, that could only be correctly assessed after the application of dermoscopy, which revealed LP-specific findings. Read More

J Dtsch Dermatol Ges 2016 Nov 10;14(11):1102-1107. Epub 2016 Nov 10.

Department of Dermatology and Venereology, Hospital Universitario, 12 de Octubre, Madrid, Spain.

Background: Although subclinical enthesopathy is a well-established diagnostic criterion for psoriatic arthritis (PsA), it is frequently overlooked, as many patients are asymptomatic. The possibility of finding a clinical clue predicting enthesopathy would help clinicians establish an early diagnosis of PsA.

Material And Methods: A prospective single-center study of a total of 90 patients with psoriasis was conducted to assess the presence of entheseal abnormalities as detected by ultrasound, and to determine any correlation with nail involvement. Read More

Skin Appendage Disord 2016 Sep 13;2(1-2):22-25. Epub 2016 May 13.

Department of Dermatology, 'Dr. Manuel Gea González' General Hospital, Mexico City, Mexico.

Background: Patients with nail psoriasis have an increased risk of onychomycosis. Previous studies suggest it may be due to structural changes of the nails. However, a genetic predisposition seems to be also at play. Read More

Iran J Med Sci 2016 May;41(3 Suppl):S54

Faculty of Iranian Traditional Medicine, The School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Psoriasis is a common chronic inflammatory skin, nails, and joints disease related to the immune system by periods of exacerbations and remissions. It is characterized by thick end, erythematous, and scaling lesions, which affects about 2 to 4 percent of the general population. The disease occurs equally in both sexes and the most common form of the disease is psoriasis vulgaris. Read More

J Autoimmun 2017 Jan 9;76:21-37. Epub 2016 Nov 9.

Department of Dermatology, School of Medicine, University of California, Davis, USA.

Psoriatic arthritis (PsA) is a heterogeneous disease that can involve a variety of distinct anatomical sites including a patient's peripheral and axial joints, entheses, skin and nails. Appropriate management of PsA requires early diagnosis, monitoring of disease activity, and utilization of cutting edge therapies. To accomplish the former there are a variety of PsA-specific tools available to screen, diagnose, and assess patients. Read More

Int J Dermatol 2016 Dec 15;55(12):1304-1310. Epub 2016 Jul 15.

Department of Dermatology, Hotel Dieu de France University Hospital, Beirut, Lebanon.

Splinter hemorrhages (SHs) of the nails represent a frequent although not specific clinical finding that has been associated with conditions of varying severity. However, to date, there is no single report of their characteristics and etiologies. The aim of this study is to guide clinical practice by reviewing all of the data concerning SH of the nails that have become available since the first description of this condition was published in 1923, with particular reference to all clinical features, associated medical conditions, pathogenesis, and necessary workup. Read More

Int J Dermatol 2017 Feb 3;56(2):e28-e29. Epub 2016 Nov 3.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

J Dermatolog Treat 2017 Jun 24;28(4):342-346. Epub 2016 Oct 24.

b Department of Dermatology, Psoriasis and Skin Treatment Center , University of California San Francisco , San Francisco , CA , USA.

Individuals with obsessive-compulsive features frequently visit dermatologists for complaints of the skin, hair or nails, and often progress towards a chronic relapsing course due to the challenge associated with accurate diagnosis and management of their psychiatric symptoms. The current DSM-5 formally recognizes body dysmorphic disorder, trichotillomania, neurotic excoriation and body focused repetitive behavior disorder as psychodermatological disorders belonging to the category of Obsessive-Compulsive and Related Disorders. However there is evidence that other relevant skin diseases such as delusions of parasitosis, dermatitis artefacta, contamination dermatitis, AIDS phobia, trichotemnomania and even lichen simplex chronicus possess prominent obsessive-compulsive characteristics that do not necessarily fit the full diagnostic criteria of the DSM-5. Read More

J Dermatolog Treat 2017 Jun 6;28(4):347-352. Epub 2016 Dec 6.

b Chicago Medical School , Rosalind Franklin University of Medicine and Science , North Chicago , IL , USA.

Introduction: Patient-reported outcome measures are increasingly utilized in dermatology to assess the impact of skin disease on quality of life. Despite recognition of the influence of skin disease on intimate relationships, an instrument to assess intimacy has not been developed. The objective of this study was to create the dermatologic intimacy scale (DIS) and administer the prototype to a patient population. Read More

Eur J Dermatol 2017 Feb;27(1):20-27

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Japan.

Background: MicroRNA levels in sera or hair may potentially be useful biomarkers for various diseases. The diagnosis of nail diseases is sometimes difficult, and nail psoriasis without skin lesions is indistinguishable from nail changes caused by other diseases.

Objectives: We evaluated nail microRNA levels as biomarkers for the diagnosis of psoriasis patients. Read More

J Dermatol 2017 Apr 11;44(4):355-362. Epub 2016 Oct 11.

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.

Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). Read More

Med Ultrason 2016 Sep;18(3):312-7

Dermatology Department, "Iuliu Haţieganu" University of Medicine and Pharmacy,Cluj-Napoca, Romania.

Aim: To evaluate the morphostructural aspects and nail vascularity in the nail unit of patients with psoriasis, and to evaluate whether there are differences among psoriatic patients with and without nail involvement.

Material And Methods: Nail plates and nail bed changes, nail fold vessel resistance index (NVRI), power and color Doppler blood flow appearances were investigated in 23 patients with moderate-to-severe psoriasis, with and without nail involvement, and compared to those of 11 healthy participants.

Results: Ventral nail plate deposits were present only in psoriasis patients. Read More

An Bras Dermatol 2016 Jul-Aug;91(4):442-5

Department of Biochemistry, Adana Public Health Laboratory-Adana, Turkey.

Background: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. Read More

Mycoses 2017 Jan 15;60(1):6-10. Epub 2016 Aug 15.

Department of Specialized, Diagnostic and Experimental Medicine, Division of Dermatology, University of Bologna, Bologna, Italy.

Onychomycosis is the most common nail disease and affects large parts of the population. Psoriasis is a frequently encountered skin disorder with nail involvement being found in up to 80% of the patients at some time of the course of the disease. It has been postulated that onychomycosis occurs more frequently in patients with nail psoriasis, but the results of studies in the literature are controversial. Read More

Iran J Med Sci 2016 May;41(3):S54

Faculty of Iranian Traditional Medicine, The School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Psoriasis is a common chronic inflammatory skin, nails, and joints disease related to the immune system by periods of exacerbations and remissions. It is characterized by thick end, erythematous, and scaling lesions, which affects about 2 to 4 percent of the general population. The disease occurs equally in both sexes and the most common form of the disease is psoriasis vulgaris. Read More

J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):1-7

Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.

Psoriasis is a chronic, recurring skin disease affecting 2-4% of the population. Genetic predisposition and precipitating factors play a role in its etiology. The disease can occur in any age or gender group. Read More

J Med Assoc Thai 2016 Apr;99(4):418-23

Objective: To determine bacterial colonization of skin, scalp, nares, nails, and psoriasis lesion in Thai psoriasis patients and compare findings with those of healthy controls.

Material And Method: Sixty patients with chronic plaque-type psoriasis and 60 healthy controls of similar age and gender were enrolled. Swabs of nares, scalp, nails, and non-lesional skin were taken from all subjects. Read More

J Eur Acad Dermatol Venereol 2017 Jan 10;31(1):e49-e50. Epub 2016 Jun 10.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine- Ain Shams University, Cairo, Egypt.

Vopr Kurortol Fizioter Lech Fiz Kult 2016 May-Jun;93(3):42-45

Novosibirsk State Medical University, Russian Ministry of Health, Novosibirsk, Russia.

The frequency of the development of clinically significant changes in the nail plates was estimated in the present study that included 454 patients presenting with psoriasis and 140 patients with eczema characterized by the localization of the pathological process on the skin of the wrists and/or feet. The changes in the nail plates were shown to occur in 56,2% of the patients with psoriasis and in 90,7% of those suffering from eczema. The capillaroscopy of the microvessels feeding the affected nails was carried out to determine the type of the capillaroscopic picture. Read More

MMW Fortschr Med 2016 Jun;158(11)

Z Rheumatol 2016 Jun;75(5):471-88

Internistisch-rheumatologische Praxis, München, Deutschland.

Psoriatic arthritis is a chronic inflammatory disease of the musculoskeletal system with association to skin psoriasis and is characterized by variable clinical symptoms with very heterogeneous degrees of disease suffering for patients. Clinical manifestations essentially include alterations to the skin and nails, peripheral arthritis, enthesitis, dactylitis and/or spinal involvement. This variability necessitates an individualized therapy of patients with different therapy targets. Read More

Clin Rheumatol 2016 Aug 1;35(8):2031-2037. Epub 2016 Jun 1.

Rheumatology Unit, Department of Medicine and Geriatrics, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong.

Psoriatic nail disease and distal interphalangeal (DIP) arthritis both are common manifestations of psoriatic arthritis (PsA). Several clinical characteristics are allegedly associated with DIP joint damage, particularly nail psoriasis. However, there is little evidence to substantiate this phenomenon. Read More

J Dermatol 2016 Oct;43(10):1217-1220

Department of Medical and Biological Sciences, Rheumatology Clinic, University of Udine, Udine, Italy.

Differentiation between psoriatic arthritis (PsA) sine psoriasis and rheumatoid arthritis (RA) may be a challenge, especially in the early stages, hence the need for new instrumental markers to assist their diagnosis. In this study, we investigated possible dermoscopic differences in vascular appearance of nail fold and elbow (a classic site of repeated trauma) in these two conditions. Fifteen patients with PsA sine psoriasis, 12 patients with RA and 12 controls were included in the study. Read More

Hautarzt 2016 Jun;67(6):454-63

Klinik für Dermatologie und Phlebologie, Vivantes Klinikum im Friedrichshain, Landsberger Allee 49, 10249, Berlin, Deutschland.

A large proportion of patients with plaque psoriasis suffer from psoriatic lesions of the scalp, nails, and intertrigines. These locations can also be soley or predominantly affected. Scalp psoriasis, nail psoriasis, and inverse psoriasis are often perceived as particularly stigmatizing. Read More