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    638 results match your criteria Psoriasis Nails

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    Nail Enthesis Ultrasound in Psoriasis and Psoriatic Arthritis: A Report from the 2016 GRAPPA Annual Meeting.
    J Rheumatol 2017 May;44(5):688-690
    From the Division of Rheumatology, and Division of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
    Musculoskeletal ultrasonography is gaining favor in the evaluation of enthesitis in patients with psoriasis and psoriatic arthritis (PsA). Imaging modalities have shown that the enthesis of the distal interphalangeal joint has a close relationship to the nail itself. Studies have focused on the structure and morphology of nails to determine an association between psoriasis nail changes and the presence or severity of PsA. Read More

    A Novel Apremilast Nail Lacquer Formulation for the Treatment of Nail Psoriasis.
    AAPS PharmSciTech 2017 Apr 28. Epub 2017 Apr 28.
    Department of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS, 38677, USA.
    The objective was to prepare a novel nail lacquer formulation to improve the ungual and trans-ungual delivery of apremilast for the potential treatment of nail psoriasis. Nail lacquer formulation was prepared using Eudragit® S 100 as a film-forming polymer and the mixture of ethanol, ethyl acetate, and water as a solvent system. As a result of high-throughput screening studies, dexpanthenol and salicylic acid were found to be the potential penetration enhancers. Read More

    Evidence and Suggested Therapeutic Approach in Psoriasis of Difficult-to-treat Areas: Palmoplantar Psoriasis, Nail Psoriasis, Scalp Psoriasis, and Intertriginous Psoriasis.
    Indian J Dermatol 2017 Mar-Apr;62(2):113-122
    Department of Dermatology, Dr B. C. Roy Post Graduate Institute of Pediatric Sciences, Kolkata, West Bengal, India.
    Psoriasis is resistant to treatment and it shows frequent relapse; systemic treatment is often associated with toxicities, and long-term safety data are lacking for most of the newer drugs like biologics. Moreover, some body areas such as hands, feet, intertriginous areas, scalp, and nails are even more resistant. Frequently, systemic treatments are necessary considering the higher psychological impact on the patient. Read More

    Role of nail bed methotrexate injections in isolated nail psoriasis: conventional drug via an unconventional route.
    Clin Exp Dermatol 2017 Apr 10. Epub 2017 Apr 10.
    Department of Dermatology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
    Nail psoriasis can be a debilitating condition; however, in patients with isolated nail involvement, the use of toxic systemic therapies such as methotrexate may not be justified. We report on 4 patients (30 involved nails between them), who were treated with injections of methotrexate (0.1 mL of a 25 mg/mL solution) into the nail bed at 3-weekly intervals. Read More

    Subclinical enthesitis in nail psoriasis patients: a case-control study.
    J Dtsch Dermatol Ges 2017 Apr;15(4):405-412
    Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
    Background: Patients with nail psoriasis have a higher prevalence of psoriatic arthritis; however, the pathogenetic relationship between these two disorders is as yet unclear. Entheses have been suggested as disease epicenter, which might explain the pathogenesis on an anatomical level.

    Objective: To contribute to the elucidation of the hypothesis as regards the anatomical link between nail psoriasis and psoriatic arthritis, with the extensor enthesis of the distal interphalangeal joint as the epicenter. Read More

    Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography.
    Skin Appendage Disord 2017 Jan 21;2(3-4):102-108. Epub 2016 Sep 21.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.
    Background: Nail psoriasis is a painful and disfiguring nail disease that often leads to invasive biopsies. Dermoscopy of the hyponychium can be useful in the diagnosis showing twisted coiled vessels. Structural features of nail psoriasis have been described with optical coherence tomography (OCT). Read More

    Comparative microscopic analysis of nail clippings from patients with cutaneous psoriasis and psoriatic arthritis.
    An Bras Dermatol 2017 Jan-Feb;92(1):21-25
    Department of Rheumatology of the Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) - Porto Alegre (RS), Brazil.
    Background:: The nail involvement in psoriasis is related to psoriatic arthritis and may represent a predictor of the disease.

    Objectives:: To analyze, through nail clipping, clinically normal and dystrophic nails of patients with cutaneous psoriasis and psoriatic arthritis.

    Methods:: This is a cross-sectional multicenter study, conducted between August 2011 and March 2012. Read More

    Dermoscopic features of nail psoriasis treated with biologics.
    J Dermatol 2017 May 2;44(5):538-541. Epub 2017 Feb 2.
    Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
    Although psoriatic nail lesions are small, they cause considerable discomfort for patients and adversely affect quality of life. Few studies have evaluated the dermoscopic features of psoriatic nails. The aim of this study was to clarify the dermoscopic features of nail psoriasis and identify those that reflect psoriatic activity. Read More

    [Psoriatic arthritis : Overview of drug therapy options and administration characteristics].
    Hautarzt 2017 Feb;68(2):153-169
    Internistisch-rheumatologische Praxis, München, Deutschland.
    Psoriatic arthritis is a chronic inflammatory disease of the musculoskeletal system with association to skin psoriasis and is characterized by variable clinical symptoms with very heterogeneous degrees of disease suffering for patients. Clinical manifestations essentially include alterations to the skin and nails, peripheral arthritis, enthesitis, dactylitis and/or spinal involvement. This variability necessitates an individualized therapy of patients with different therapy targets. Read More

    The impact of age on psoriasis health care in Germany.
    J Eur Acad Dermatol Venereol 2017 May 9;31(5):870-875. Epub 2017 Mar 9.
    Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
    Introduction: Inequality between age groups has been demonstrated in the prescription of biologics, yet systematic real-world data about age-related differences in psoriasis care are missing.

    Objective: To investigate disparities in psoriasis characteristics by age groups and to identify potential impact on psoriasis health care.

    Patients And Methods: Data analysis included 3615 patients from the German psoriasis registry PsoBest, which observes adult patients with moderate-to-severe psoriasis or psoriatic arthritis (PsA) on systemic treatment over a time period of 10 years. Read More

    Lesions on the back of hands and female gender predispose to stigmatization in patients with psoriasis.
    J Am Acad Dermatol 2017 Apr 6;76(4):648-654.e2. Epub 2017 Jan 6.
    Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address:
    Background: Psoriasis vulgaris is characterized by disfiguring and stigmatizing skin lesions. The links among lesions distribution, severity, and stigmatization remain unclear.

    Objective: We sought to investigate if the involvement of visible and sensitive areas is linked to stigmatization. Read More

    Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis.
    Joint Bone Spine 2016 Dec 5. Epub 2016 Dec 5.
    Department of Rheumatology, Brest University Hospital, 29280 Brest, France; Ultrasound Unit Department, Brest University Hospital, 29280 Brest, France. Electronic address:
    Objectives: To detect subclinical entheses and nail abnormalities using gray-scale (GS) and power Doppler ultrasonography (PDUS) between patients with nail psoriasis and those with inverse and scalp psoriasis.

    Methods: In this prospective monocentric study, patients with nail, inverse and scalp psoriasis, without psoriatic arthritis or systemic treatment, were included. Clinical evaluation and ultrasonographic assessment of 14 entheses and 12 nails were done by a dermatologist (clinical assessment) and a rheumatologist (ultrasonographic assessment). Read More

    State of the art of ultrasound in the assessment of psoriasis and psoriatic arthritis.
    Expert Rev Clin Immunol 2017 May 2;13(5):439-447. Epub 2016 Dec 2.
    a Division of Musculoskeletal and Rheumatic Disorders , Instituto Nacional de Rehabilitación , México City , Mexico.
    Introduction: Ultrasound (US) is a rapidly evolving technique that is gaining increasing success in the assessment of psoriatic arthritis (PsA). Recently, new research avenues have been opened, and these are focused on the potential of US for the assessment of extra musculoskeletal areas such as skin and nails. This permits work on the concept of 'holistic US assessment of PsA'. Read More

    Nail Psoriasis: A Systematic Evaluation in 313 Children with Psoriasis.
    Pediatr Dermatol 2017 Jan 22;34(1):58-63. Epub 2016 Nov 22.
    Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France.
    Background/objectives: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis.

    Methods: We performed a multicenter, cross-sectional study in 23 French dermatology centers. Read More

    Atypical case of lichen planus recognized by dermoscopy.
    Dermatol Pract Concept 2016 Oct 31;6(4):39-42. Epub 2016 Oct 31.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Lichen planus (LP) is an inflammatory disease that affects the skin-mainly the extremities and the trunk-the mucous membranes, the genitalia, the nails and the scalp. The diagnosis of LP is usually established clinically based on the typical morphology and distribution of the lesions in conjunction with the associated itch. We report a patient with LP manifesting highly psoriasiform lesions, that could only be correctly assessed after the application of dermoscopy, which revealed LP-specific findings. Read More

    Nail involvement can predict enthesopathy in patients with psoriasis.
    J Dtsch Dermatol Ges 2016 Nov 10;14(11):1102-1107. Epub 2016 Nov 10.
    Department of Dermatology and Venereology, Hospital Universitario, 12 de Octubre, Madrid, Spain.
    Background: Although subclinical enthesopathy is a well-established diagnostic criterion for psoriatic arthritis (PsA), it is frequently overlooked, as many patients are asymptomatic. The possibility of finding a clinical clue predicting enthesopathy would help clinicians establish an early diagnosis of PsA.

    Material And Methods: A prospective single-center study of a total of 90 patients with psoriasis was conducted to assess the presence of entheseal abnormalities as detected by ultrasound, and to determine any correlation with nail involvement. Read More

    Role of HLA-DR Alleles to Increase Genetic Susceptibility to Onychomycosis in Nail Psoriasis.
    Skin Appendage Disord 2016 Sep 13;2(1-2):22-25. Epub 2016 May 13.
    Department of Dermatology, 'Dr. Manuel Gea González' General Hospital, Mexico City, Mexico.
    Background: Patients with nail psoriasis have an increased risk of onychomycosis. Previous studies suggest it may be due to structural changes of the nails. However, a genetic predisposition seems to be also at play. Read More

    Psoriasis and Topical Iranian Traditional Medicine.
    Iran J Med Sci 2016 May;41(3 Suppl):S54
    Faculty of Iranian Traditional Medicine, The School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Psoriasis is a common chronic inflammatory skin, nails, and joints disease related to the immune system by periods of exacerbations and remissions. It is characterized by thick end, erythematous, and scaling lesions, which affects about 2 to 4 percent of the general population. The disease occurs equally in both sexes and the most common form of the disease is psoriasis vulgaris. Read More

    Management of psoriatic arthritis: Early diagnosis, monitoring of disease severity and cutting edge therapies.
    J Autoimmun 2017 Jan 9;76:21-37. Epub 2016 Nov 9.
    Department of Dermatology, School of Medicine, University of California, Davis, USA.
    Psoriatic arthritis (PsA) is a heterogeneous disease that can involve a variety of distinct anatomical sites including a patient's peripheral and axial joints, entheses, skin and nails. Appropriate management of PsA requires early diagnosis, monitoring of disease activity, and utilization of cutting edge therapies. To accomplish the former there are a variety of PsA-specific tools available to screen, diagnose, and assess patients. Read More

    Splinter hemorrhages of the nails: a systematic review of clinical features and associated conditions.
    Int J Dermatol 2016 Dec 15;55(12):1304-1310. Epub 2016 Jul 15.
    Department of Dermatology, Hotel Dieu de France University Hospital, Beirut, Lebanon.
    Splinter hemorrhages (SHs) of the nails represent a frequent although not specific clinical finding that has been associated with conditions of varying severity. However, to date, there is no single report of their characteristics and etiologies. The aim of this study is to guide clinical practice by reviewing all of the data concerning SH of the nails that have become available since the first description of this condition was published in 1923, with particular reference to all clinical features, associated medical conditions, pathogenesis, and necessary workup. Read More

    Obsessive-compulsive skin disorders: a novel classification based on degree of insight.
    J Dermatolog Treat 2016 Oct 24:1-5. Epub 2016 Oct 24.
    b Department of Dermatology, Psoriasis and Skin Treatment Center , University of California San Francisco , San Francisco , CA , USA.
    Individuals with obsessive-compulsive features frequently visit dermatologists for complaints of the skin, hair or nails, and often progress towards a chronic relapsing course due to the challenge associated with accurate diagnosis and management of their psychiatric symptoms. The current DSM-5 formally recognizes body dysmorphic disorder, trichotillomania, neurotic excoriation and body focused repetitive behavior disorder as psychodermatological disorders belonging to the category of Obsessive-Compulsive and Related Disorders. However there is evidence that other relevant skin diseases such as delusions of parasitosis, dermatitis artefacta, contamination dermatitis, AIDS phobia, trichotemnomania and even lichen simplex chronicus possess prominent obsessive-compulsive characteristics that do not necessarily fit the full diagnostic criteria of the DSM-5. Read More

    The dermatologic intimacy scale: quantitatively measuring the impact of skin disease on intimacy.
    J Dermatolog Treat 2016 Dec 6:1-6. Epub 2016 Dec 6.
    b Chicago Medical School , Rosalind Franklin University of Medicine and Science , North Chicago , IL , USA.
    Introduction: Patient-reported outcome measures are increasingly utilized in dermatology to assess the impact of skin disease on quality of life. Despite recognition of the influence of skin disease on intimate relationships, an instrument to assess intimacy has not been developed. The objective of this study was to create the dermatologic intimacy scale (DIS) and administer the prototype to a patient population. Read More

    Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers.
    Eur J Dermatol 2017 Feb;27(1):20-27
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Japan.
    Background: MicroRNA levels in sera or hair may potentially be useful biomarkers for various diseases. The diagnosis of nail diseases is sometimes difficult, and nail psoriasis without skin lesions is indistinguishable from nail changes caused by other diseases.

    Objectives: We evaluated nail microRNA levels as biomarkers for the diagnosis of psoriasis patients. Read More

    High-frequency sonography in the evaluation of nail psoriasis.
    Med Ultrason 2016 Sep;18(3):312-7
    Dermatology Department, "Iuliu Haţieganu" University of Medicine and Pharmacy,Cluj-Napoca, Romania.
    Aim: To evaluate the morphostructural aspects and nail vascularity in the nail unit of patients with psoriasis, and to evaluate whether there are differences among psoriatic patients with and without nail involvement.

    Material And Methods: Nail plates and nail bed changes, nail fold vessel resistance index (NVRI), power and color Doppler blood flow appearances were investigated in 23 patients with moderate-to-severe psoriasis, with and without nail involvement, and compared to those of 11 healthy participants.

    Results: Ventral nail plate deposits were present only in psoriasis patients. Read More

    Nail abnormalities in patients with vitiligo.
    An Bras Dermatol 2016 Jul-Aug;91(4):442-5
    Department of Biochemistry, Adana Public Health Laboratory-Adana, Turkey.
    Background: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. Read More

    Onychomycosis in patients with nail psoriasis: a point to point discussion.
    Mycoses 2017 Jan 15;60(1):6-10. Epub 2016 Aug 15.
    Department of Specialized, Diagnostic and Experimental Medicine, Division of Dermatology, University of Bologna, Bologna, Italy.
    Onychomycosis is the most common nail disease and affects large parts of the population. Psoriasis is a frequently encountered skin disorder with nail involvement being found in up to 80% of the patients at some time of the course of the disease. It has been postulated that onychomycosis occurs more frequently in patients with nail psoriasis, but the results of studies in the literature are controversial. Read More

    Psoriasis and Topical Iranian Traditional Medicine.
    Iran J Med Sci 2016 May;41(3):S54
    Faculty of Iranian Traditional Medicine, The School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Psoriasis is a common chronic inflammatory skin, nails, and joints disease related to the immune system by periods of exacerbations and remissions. It is characterized by thick end, erythematous, and scaling lesions, which affects about 2 to 4 percent of the general population. The disease occurs equally in both sexes and the most common form of the disease is psoriasis vulgaris. Read More

    A multi-centred open trial of “Dr Michaels®” (also branded as Soratinex®) topical product family in psoriasis.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):1-7
    Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.
    Psoriasis is a chronic, recurring skin disease affecting 2-4% of the population. Genetic predisposition and precipitating factors play a role in its etiology. The disease can occur in any age or gender group. Read More

    Prevalence of Cutaneous Bacterial Colonization in Thai Patients with Psoriasis.
    J Med Assoc Thai 2016 Apr;99(4):418-23
    Objective: To determine bacterial colonization of skin, scalp, nares, nails, and psoriasis lesion in Thai psoriasis patients and compare findings with those of healthy controls.

    Material And Method: Sixty patients with chronic plaque-type psoriasis and 60 healthy controls of similar age and gender were enrolled. Swabs of nares, scalp, nails, and non-lesional skin were taken from all subjects. Read More

    [The clinical effectiveness of the application of interferential currents for the combined treatment of onychopathies associated with psoriasis and eczema].
    Vopr Kurortol Fizioter Lech Fiz Kult 2016 May-Jun;93(3):42-5
    Novosibirsk State Medical University, Russian Ministry of Health, Novosibirsk, Russia.
    The frequency of the development of clinically significant changes in the nail plates was estimated in the present study that included 454 patients presenting with psoriasis and 140 patients with eczema characterized by the localization of the pathological process on the skin of the wrists and/or feet. The changes in the nail plates were shown to occur in 56,2% of the patients with psoriasis and in 90,7% of those suffering from eczema. The capillaroscopy of the microvessels feeding the affected nails was carried out to determine the type of the capillaroscopic picture. Read More

    [Psoriatic arthritis : Overview of drug therapy options and administration characteristics].
    Z Rheumatol 2016 Jun;75(5):471-88
    Internistisch-rheumatologische Praxis, München, Deutschland.
    Psoriatic arthritis is a chronic inflammatory disease of the musculoskeletal system with association to skin psoriasis and is characterized by variable clinical symptoms with very heterogeneous degrees of disease suffering for patients. Clinical manifestations essentially include alterations to the skin and nails, peripheral arthritis, enthesitis, dactylitis and/or spinal involvement. This variability necessitates an individualized therapy of patients with different therapy targets. Read More

    Psoriatic nail involvement and its relationship with distal interphalangeal joint disease.
    Clin Rheumatol 2016 Aug 1;35(8):2031-7. Epub 2016 Jun 1.
    Rheumatology Unit, Department of Medicine and Geriatrics, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong.
    Psoriatic nail disease and distal interphalangeal (DIP) arthritis both are common manifestations of psoriatic arthritis (PsA). Several clinical characteristics are allegedly associated with DIP joint damage, particularly nail psoriasis. However, there is little evidence to substantiate this phenomenon. Read More

    Dermoscopy of nail fold and elbow in the differential diagnosis of early psoriatic arthritis sine psoriasis and early rheumatoid arthritis.
    J Dermatol 2016 Oct;43(10):1217-1220
    Department of Medical and Biological Sciences, Rheumatology Clinic, University of Udine, Udine, Italy.
    Differentiation between psoriatic arthritis (PsA) sine psoriasis and rheumatoid arthritis (RA) may be a challenge, especially in the early stages, hence the need for new instrumental markers to assist their diagnosis. In this study, we investigated possible dermoscopic differences in vascular appearance of nail fold and elbow (a classic site of repeated trauma) in these two conditions. Fifteen patients with PsA sine psoriasis, 12 patients with RA and 12 controls were included in the study. Read More

    [Psoriasis in special localizations].
    Hautarzt 2016 Jun;67(6):454-63
    Klinik für Dermatologie und Phlebologie, Vivantes Klinikum im Friedrichshain, Landsberger Allee 49, 10249, Berlin, Deutschland.
    A large proportion of patients with plaque psoriasis suffer from psoriatic lesions of the scalp, nails, and intertrigines. These locations can also be soley or predominantly affected. Scalp psoriasis, nail psoriasis, and inverse psoriasis are often perceived as particularly stigmatizing. Read More

    Nail disorders in older people, and aspects of their pharmaceutical treatment.
    Int J Pharm 2016 Oct 11;512(2):405-411. Epub 2016 May 11.
    UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK. Electronic address:
    The aim of this paper was to explore how aging influences the nail unit, its disorders and its response to treatment, and to identify some of the age-related gaps in the ungual drug delivery literature. Aging causes obvious changes to the nail, some of which are inherently due to old age, while others are due to diseases/conditions which become more prevalent as we age. Alterations in the nail plate's colour, contour, thickness, fragility, surface features, cell size, chemical composition and growth rate are some of the changes, with toenails and fingernails showing different effects. Read More

    Severe Onychodystrophy due to Allergic Contact Dermatitis from Acrylic Nails.
    Skin Appendage Disord 2015 Sep 18;1(2):91-4. Epub 2015 Jul 18.
    Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Fla., USA.
    Acrylic nails, including sculptured nails and the new ultraviolet-curable gel polish lacquers, have been associated with allergic contact dermatitis (ACD). We report 2 cases of ACD to acrylic nails with severe onychodystrophy and psoriasiform changes including onycholysis and subungual hyperkeratosis. In both cases, the patients did not realize the association between the use of acrylate-based manicures and nail changes. Read More

    Urea: A Clinically Oriented Overview from Bench to Bedside.
    J Drugs Dermatol 2016 May;15(5):633-9
    Urea is an important hygroscopic component of the epidermis, where it participates in the maintenance of skin hydration as part of the skin's source of natural moisturizing factor (NMF) in the outer most layers. Xerotic skin, which is frequently characterized as NMF-deficient, is a unifying trait of dermatoses such as atopic dermatitis (AD), psoriasis, and ichthyosis vulgaris. The reduced hygroscopic potential of pathologically dry skin leads to unregulated transepidermal water loss (TEWL), epidermal hyperproliferation, and inhibited desquamation; all which clinically translate to hyperkeratotic and possibly pruritic skin. Read More

    Psoronychomycosis: A New Term for an Old Problem.
    J Cutan Med Surg 2016 May 18;20(3):279-80. Epub 2016 Mar 18.
    Dermatrials Research Inc, Hamilton, ON, Canada
    Occasionally, psoriatic nail changes are seen in psoriatic patients. The prevalence of psoriasis of the nails has been reported to range from 15% to 79%. Even with effective systemic treatment for psoriasis, the nails may not improve, and these nails are considered nonresponsive psoriatic nails. Read More

    Application of Hansen Solubility Parameters to predict drug-nail interactions, which can assist the design of nail medicines.
    Eur J Pharm Biopharm 2016 May 23;102:32-40. Epub 2016 Feb 23.
    Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:
    We hypothesised that Hansen Solubility Parameters (HSPs) can be used to predict drug-nail affinities. Our aims were to: (i) determine the HSPs (δD, δP, δH) of the nail plate, the hoof membrane (a model for the nail plate), and of the drugs terbinafine HCl, amorolfine HCl, ciclopirox olamine and efinaconazole, by measuring their swelling/solubility in organic liquids, (ii) predict nail-drug interactions by comparing drug and nail HSPs, and (iii) evaluate the accuracy of these predictions using literature reports of experimentally-determined affinities of these drugs for keratin, the main constituent of the nail plate and hoof. Many solvents caused no change in the mass of nail plates, a few solvents deswelled the nail, while others swelled the nail to varying extents. Read More

    Are biologics useful for nail psoriasis?
    Medwave 2016 Jan 11;16 Suppl 1:e6363. Epub 2016 Jan 11.
    Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile; Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Apart from involving skin, psoriasis can compromise the nails and adjacent structures. Even though there are multiple therapeutic alternatives, there is great interest in biological therapy, but no consensus on its role exists. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified two systematic reviews including three randomized trials. Read More

    Psoriatic arthritis: complexities, comorbidities and implications for the clinic.
    Expert Rev Clin Immunol 2016 28;12(4):405-16. Epub 2016 Jan 28.
    b Department of Rheumatology , St Vincent's University Hospital , Dublin , Ireland.
    Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory disease that affects peripheral joints, entheses and axial sites in addition to both skin and nails. There is considerable evidence to support the assertion that PsA is actually a multisystem disease. Contrary to earlier beliefs, PsA is not only common but also a potentially deforming and disabling disease. Read More

    Disease Severity, Quality of Life, and Psychiatric Morbidity in Patients With Psoriasis With Reference to Sociodemographic, Lifestyle, and Clinical Variables: A Prospective, Cross-Sectional Study From Lahore, Pakistan.
    Prim Care Companion CNS Disord 2015 25;17(3). Epub 2015 Jun 25.
    AIMC Research Cell, Allama Iqbal Medical College, Jinnah Hospital, Lahore (Dr Khawaja); Department of Dermatology Services, Institute of Medical Sciences Services Hospital, Lahore (Dr Bokhari); Department of Dermatology, Fatima Jinnah Medical College, Sir Ganga Ram Hospital, Lahore (Dr Rasheed); Department of Dermatology, Postgraduate Medical Institute, Lahore General Hospital, Lahore (Dr Shahzad); Department of Statistics, National College of Business Administration and Economics, Lahore (Dr Hanif); Lahore Business School, The University of Lahore, Lahore (Dr Qadeer), Pakistan; and Department of Psychiatry, College of Medicine, Central Michigan University, East Campus, Saginaw (Dr Jafferany).
    Background: Psoriasis is an immune-mediated, chronic disease with a genetic background that involves skin, nails, and joints. The incidence of psoriasis varies from 2.0% to 4. Read More

    Prevalence of Psoriatic Arthritis in Primary Care Patients With Psoriasis.
    Arthritis Rheumatol 2016 Apr;68(4):924-31
    Erasmus University Medical Centre, Rotterdam, The Netherlands.
    Objective: To estimate the prevalence of psoriatic arthritis (PsA) in primary care patients diagnosed as having psoriasis and to estimate the prevalence of musculoskeletal symptoms in psoriasis patients in primary care.

    Methods: We conducted a cross-sectional study in adult primary care patients with psoriasis. Responding patients reporting pain in joints, entheses, or the lower back were interviewed by telephone to determine eligibility and, if eligible, were invited for clinical evaluation. Read More

    Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands.
    Exp Dermatol 2016 Mar 12;25(3):187-93. Epub 2016 Jan 12.
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
    To explore the role of amphiregulin in inflammatory epidermal hyperplasia, we overexpressed human AREG (hAREG) in FVB/N mice using a bovine K5 promoter. A construct containing AREG coding sequences flanked by 5' and 3' untranslated region sequences (AREG-UTR) led to a >10-fold increase in hAREG expression compared to an otherwise-identical construct containing only the coding region (AREG-CDR). AREG-UTR mice developed tousled, greasy fur as well as elongated nails and thickened, erythematous tail skin. Read More

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