770 results match your criteria Psoriasis Nails


The Impact of Onychopathies on Quality of Life: A Hospital-based, Cross-sectional Study.

Indian Dermatol Online J 2020 Mar-Apr;11(2):187-194. Epub 2020 Mar 9.

Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Background: Onychopathies or nail disorders are associated with social stigma and causes limitation of daily activities by hampering the function of both fingers and toes.

Aim: To evaluate the impact of onychopathies on quality of life (QoL) and compare the severity of impact on QoL in various nail disorders.

Materials And Methods: A hospital-based cross-sectional study consisting of 540 patients with onychopathies was conducted in the dermatology outpatient department. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_272_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247629PMC

Pharmacotherapy and inappropriate prescriptions in patients with psoriasis.

Int J Clin Pharm 2020 May 30. Epub 2020 May 30.

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Calle 105 No. 14-140, 660003, Pereira, Risaralda, Colombia.

Background Psoriasis is a chronic inflammatory and systemic disease that primarily affects the skin, nails, and joints. Some medications have been linked to worsening clinical manifestations of cutaneous psoriasis. Objective To identify pharmacological treatments and drugs related to worsening dermatological lesions in patients with psoriasis. Read More

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http://dx.doi.org/10.1007/s11096-020-01061-wDOI Listing

Epidemiology of psoriasis in hard-to-treat body locations: data from the Danish skin cohort.

BMC Dermatol 2020 May 20;20(1). Epub 2020 May 20.

Eli Lilly and Company, Indianapolis, Indiana, USA.

Background: Having psoriasis in hard-to-treat areas, i.e. the scalp, face, palms, soles, nails, and genitals, respectively, can impair patients' quality of life. Read More

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http://dx.doi.org/10.1186/s12895-020-00099-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238562PMC

Psoriasis in difficult to treat areas: treatment role in improving health-related quality of life and perception of the disease stigma.

J Dermatolog Treat 2020 May 28:1-4. Epub 2020 May 28.

Dermatology Unit, System Medicine Department, University of Tor Vergata, Rome, Italy.

When psoriasis affects scalp, nails, palms and soles, it is considered difficult to treat and causes severe impairment of life quality. We evaluated which difficult site most impacts on the patient's quality of life and how quality of life changes during treatment. We conducted a prospective observational study in patients receiving adalimumab over a 24 weeks period, through assessment at weeks 0, 4 and 24 using PASI, PAIN VAS, ITCH VAS, DLQI, NAPSI, PSSI. Read More

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http://dx.doi.org/10.1080/09546634.2020.1770175DOI Listing

Evaluation of pentraxin 3 level and cardiac functions in psoriatic children.

Turk J Pediatr 2020 ;62(1):39-45

Departments of Pediatric Hematology, Van Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.

Psoriasis is a chronic inflammatory disorder affecting the skin, nails, and joints. Its lifetime prevelance has been estimated to be at 1% to 3%. This study was designed to examine the association between serum pentraxin 3 (PTX3) and cardiovascular function in psoriatic children. Read More

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http://dx.doi.org/10.24953/turkjped.2020.01.006DOI Listing
January 2020

Efficacy and safety of adalimumab in difficult-to-treat psoriasis.

Dermatol Ther 2020 May 24;33(3):e13374. Epub 2020 Apr 24.

Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Psoriasis is a chronic immune-mediated inflammatory skin disorder, with a prevalence of 2% to 3% worldwide. Psoriatic lesions affecting scalp, nails, palms, and soles are considered difficult-to-treat and require specific management. When psoriasis involves these areas, it may be considered more severe even if the lesions are not extensive. Read More

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http://dx.doi.org/10.1111/dth.13374DOI Listing

A safety evaluation of dimethyl fumarate in moderate-to-severe psoriasis.

Expert Opin Drug Saf 2020 Apr 11;19(4):373-380. Epub 2020 Mar 11.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

: Psoriasis is a chronic inflammatory disorder affecting skin, nails and joints. Systemic therapy of psoriasis is based upon several drugs which include fumaric acid esters (FAEs), initially introduced in 1959. Since 2017, one of the key substances among FAE spectrum (dimethyl fumarate; DMF) was registered by the European Medicines Agency (EMA) for the treatment of moderate-to-severe psoriasis vulgaris. Read More

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http://dx.doi.org/10.1080/14740338.2020.1736553DOI Listing

A Comparison of The Effects of Clobetasol 0.05% and Photodynamic Therapy Using Aminolevulinic Acid With Red Light in the Treatment of Severe Nail Psoriasis.

J Lasers Med Sci 2020 18;11(1):3-7. Epub 2020 Jan 18.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The treatment of nail psoriasis is often difficult and unsatisfactory due to therapy resistance. This study aimed to compare the efficacy of clobetasol 0.05% ointment and photodynamic therapy (PDT) using aminolevulinic acid (ALA) and red light in the treatment of severe nail psoriasis. Read More

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http://dx.doi.org/10.15171/jlms.2020.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008734PMC
January 2020

Comparative Study of Clinical and Dermoscopic Features in Nail Psoriasis.

Indian Dermatol Online J 2020 Jan-Feb;11(1):35-40. Epub 2020 Jan 13.

Department of Dermatology, Goa Medical College, Goa, India.

Background Aims And Objectives: Nail changes have been reported in approximately 40% of psoriasis patients. Occasionally nail psoriasis may be the sole finding or the first presentation of the disease. Assessment of the nail changes associated with psoriasis can be done clinically, ultrasonographically, and most recently using a dermoscope. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_51_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001394PMC
January 2020

A woman with nail changes.

BMJ 2020 Feb 6;368:l7007. Epub 2020 Feb 6.

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine; Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1136/bmj.l7007DOI Listing
February 2020

Assessing structural damage progression in psoriatic arthritis and its role as an outcome in research.

Arthritis Res Ther 2020 02 3;22(1):18. Epub 2020 Feb 3.

Swedish Medical Center/Providence St. Joseph Health and University of Washington, 601 Broadway Suite 600, Seattle, WA, 98122, USA.

Psoriatic arthritis (PsA) is an immune-mediated, clinically heterogeneous disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis of the skin and nails. Persistent articular inflammation in patients with PsA can lead to structural damage, which can result in reduced physical function and quality of life. Structural damage can occur rapidly, and irreversible joint damage may be observed if patients are not treated promptly and appropriately. Read More

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http://dx.doi.org/10.1186/s13075-020-2103-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998345PMC
February 2020

In psoriasis treatment, greater improvement in skin severity predicts greater improvement in nail severity.

J Dermatolog Treat 2020 Feb 5:1-4. Epub 2020 Feb 5.

Department of Dermatology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.

Nail are important for both function and esthetic appearance and although they represent a small body surface area, dermatologic disorders affecting the nails can have a detrimental effect to the patient. Deciding on the best systemic antipsoriatic drug to treat nail psoriasis can be difficult due to the lack of nail data on their Food and Drug Administration-approved labels, as well as the variety of scoring systems used for nail psoriasis. We performed a literature review and included randomized control trials or articles based on randomized control trials for different systemic antipsoriatic drugs. Read More

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http://dx.doi.org/10.1080/09546634.2020.1720578DOI Listing
February 2020

Coexistence of Anogenital Psoriasis and Genital Warts - Is There an Optimal Treatment?

Acta Dermatovenerol Croat 2019 Dec;27(4):270-272

Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, Zagreb University Hospital Center, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

The prevalence of psoriasis is 2% of the world's population (1). Inverse psoriasis is characterized by the development of erythematous shiny plaques at intertriginous areas of the body. The prevalence of only anogenital involvement appears to be low, but involvement of the anogenital area together with other areas is found in up to 45% of patients with psoriasis (2). Read More

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December 2019

The Validity of Cutaneous Body Image as a Construct and as a Mediator of the Relationship Between Cutaneous Disease and Mental Health.

Dermatol Ther (Heidelb) 2020 Feb 16;10(1):203-211. Epub 2020 Jan 16.

Baylor Scott & White Health, Dallas, TX, USA.

Introduction: Cutaneous body image (CBI) is a construct encompassing how individuals perceive their hair, skin, and nails. Negative CBI has been related to negative psychological outcomes and body image concerns. The first aim of our study was to further validate CBI as a construct. Read More

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http://dx.doi.org/10.1007/s13555-020-00351-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994570PMC
February 2020

P wave dispersion, Tpeak-Tend interval, and Tp-e/QT ratio in children with psoriasis.

Cardiol Young 2020 Mar 8;30(3):318-322. Epub 2020 Jan 8.

Department of Dermatology, Van Yuzuncu Yil Universitiy, Van, Turkey.

Background: Psoriasis is a chronic inflammatory, multi-system disease that often begins in childhood and characterised by inflammatory skin, nails, scalp, and joint manifestations. The inflammation in psoriasis may promote some effect on the cardiac conduction system.

Objective: The aim of this study is to investigate myocardial repolarisation anomaly on the conducting system in the paediatric psoriasis using P wave dispersion, Tpeak-Tend interval, and Tp-e/QT ratio. Read More

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http://dx.doi.org/10.1017/S1047951119002968DOI Listing

Diagnostic role of ultrasound elastography for nail bed involvement in psoriasis.

Medicine (Baltimore) 2019 Dec;98(50):e17917

Departmant of Dermatology, Sakarya University Training and Research Hospital, Sakarya, Turkey.

Objective: Psoriasis is a chronic inflammatory disease that affects the skin, joints, and nails. To investigate the efficacy of sonoelastographic evaluation for assessing nail involvement and severity in psoriasis.

Materials And Methods: Thirty-one psoriasis patients and 31 healthy control subjects were included in the study. Read More

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http://dx.doi.org/10.1097/MD.0000000000017917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922432PMC
December 2019

[Clinical characteristics of psoriatic arthritis with positive rheumatoid factor or anti-cyclic citrullinated peptide antibody].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Dec;51(6):1008-1013

Department of Rheumatology, Peking University Third Hospital, Beijing 100191, China.

Objective: To analyze the clinical and laboratory features of psoriatic arthritis (PsA) patients with positive rheumatoid factor (RF) or anti-cyclic citrullinated peptide (CCP) antibody.

Methods: In the study, 77 PsA patients who were hospitalized in the Department of Rheumatology and Immunology of Peking University Third Hospital from January 2007 to June 2019 were enrolled. All the patients met Classification Criteria for Psoriatic Arthritis or Moll or Wright Criteria. Read More

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December 2019

Microscopic Examination of Nail Clippings from Patients with Palmoplantar Pustulosis.

Dermatopathology (Basel) 2019 Oct-Dec;6(4):213-219. Epub 2019 Oct 29.

Dermatologist, Private Practice, Curitiba, Brazil.

This study describes the clinical characteristics and microscopic findings of nails from 25 patients with palmoplantar pustulosis.

Methods: This is a cross-sectional study of adult patients with clear-cut palmoplantar pustulosis. Onychodystrophy severity was evaluated in fingernails using the nail psoriasis severity index (NAPSI). Read More

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http://dx.doi.org/10.1159/000503704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902250PMC
October 2019

Hydroxyurea-induced hyperpigmentation with iron deposition.

Dermatol Online J 2019 Oct 15;25(10). Epub 2019 Oct 15.

McGovern Medical School, Houston, TX.

Hydroxyurea is a chemotherapeutic agent that is used in the treatment of various hematological diseases including chronic myelogenous leukemia, polycythemia vera, and sickle cell anemia. Hydroxyurea is also used to treat psoriasis. Drug-induced hyperpigmentation is a known cutaneous side effect of hydroxyurea along with xerosis, dermal ulcers, and dermatomyositis-like eruptions. Read More

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October 2019

Recent Patents on Permeation Enhancers for Drug Delivery Through Nails.

Recent Pat Drug Deliv Formul 2019 ;13(3):203-218

Graduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre, Rio Grande do Sul, Brazil.

The human nail is a unique barrier with a keratinized constitution that favors protection and fine touch. However, many disorders can affect the nail, among them, are the onychomycosis and psoriasis. Systemic oral therapy has been applied to treat these diseases, even presenting disadvantages, including side effects, drug interactions, contraindications, toxicity, high cost and low patient compliance. Read More

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http://dx.doi.org/10.2174/1872211313666191030155837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011684PMC
January 2019
1 Read

Clinical characteristics, symptoms and burden of psoriasis and atopic dermatitis in adults.

Br J Dermatol 2019 Oct 20. Epub 2019 Oct 20.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark.

Background: There is debate as to whether psoriasis and atopic dermatitis (AD) belong to the same disease spectrum.

Objectives: To describe and compare disease characteristics, lifestyle factors and disease burden in adult patients with psoriasis and AD.

Methods: We linked registry data with clinical and patient-reported outcomes from the Danish Skin Cohort, containing 3348 and 3834 adults with dermatologist-verified psoriasis or AD respectively, and 2946 adults from the general population. Read More

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http://dx.doi.org/10.1111/bjd.18622DOI Listing
October 2019
2 Reads

Psoriatic arthritis.

F1000Res 2019 20;8. Epub 2019 Sep 20.

University of Toronto, Psoriatic Arthritis Program, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.

Psoriasis is a multisystemic, inflammatory skin condition that can affect many areas of the body, but most commonly the extensor surfaces of the elbows and knees, and sometimes the intergluteal and umbilical area. It has a prevalence of 2-4% in western adults, and 20--30% of psoriasis patients will develop psoriatic arthritis (PsA). PsA is an inflammatory musculoskeletal disease associated with cutaneous psoriasis. Read More

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http://dx.doi.org/10.12688/f1000research.19144.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758836PMC
October 2019
1 Read

Nail Involvement in Psoriatic Patients and Association with Onychomycosis: Results from a Cross-Sectional Study Performed in a Military Hospital in Tunisia.

Skin Appendage Disord 2019 Aug 5;5(5):299-303. Epub 2019 Apr 5.

Dermatology Department, Military Hospital of Tunis, Tunis, Tunisia.

Nail psoriasis has variable prevalence and heterogeneous aspects. Many of them could mimic onychomycosis (OM). It has been suggested that patients with nail psoriasis are at high risk of OM. Read More

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http://dx.doi.org/10.1159/000497825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751431PMC
August 2019
2 Reads

Impact of Psoriasis on Women

Authors:
Deidre Hooper

J Drugs Dermatol 2019 Sep;18(9):950

Psoriasis is a common, chronic inflammatory skin disease that can affect any part of the body. It is a highly visible condition with symptoms that include the appearance of red, thick, scaly patches on the arms, legs, trunk, soles of the feet, palms, and nails, but most commonly on the elbows, knees, and scalp. Read More

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September 2019

The use of ultrasonography in the diagnosis of nail disease among patients with psoriasis and psoriatic arthritis: a systematic review.

Adv Rheumatol 2019 09 5;59(1):41. Epub 2019 Sep 5.

APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100, Boulogne-Billancourt, France.

Background: Nail involvement has been described as a key clinical feature for both psoriasis (PsO) and psoriatic arthritis (PsA) and is an important risk factor in PsA. Thus, early diagnosis of nail involvement may be essential for better management of PsO and PsA. Ultrasonography is considered a highly promising method to visualize nail disease. Read More

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http://dx.doi.org/10.1186/s42358-019-0081-9DOI Listing
September 2019
3 Reads

Brodalumab for the treatment of moderate-to-severe psoriasis: case series and literature review.

Clin Cosmet Investig Dermatol 2019 10;12:509-517. Epub 2019 Jul 10.

MediCorium , Oberursel, Germany.

Brodalumab, a recombinant fully human monoclonal immunoglobulin IgG2 antibody with high affinity to human interleukin (IL)-17RA, is approved for the treatment of moderate-to-severe plaque psoriasis. In controlled clinical trials, brodalumab 210 mg administered by subcutaneous injection at weeks 0, 1, and 2, then 210 mg every 2 weeks, produced a rapid onset and sustained clinical response. Consistently, >80% of patients achieved PASI-75 and efficacy was maintained for >2 years. Read More

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http://dx.doi.org/10.2147/CCID.S211938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628099PMC
July 2019
4 Reads

Nail clipping in onychomycosis and comparison with normal nails and ungual psoriasis.

An Bras Dermatol 2019 Jul 29;94(3):344-347. Epub 2019 Jul 29.

Department of Microbiology and Mycology, Diagnostic Support Unit, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba (PR), Brazil.

Background: Of all nail disorders seen in dermatology offices, half of them are due to onychomycosis. The main differential diagnosis is nail psoriasis. The objective of this study was to compare the microscopic findings, other than the presence of fungi, in the clipping of onychomycosis versus normal nails and nail psoriasis. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668936PMC
July 2019
3 Reads

[Spectrum of psoriatic conditions].

Ned Tijdschr Geneeskd 2019 07 29;163. Epub 2019 Jul 29.

UMC Utrecht, afd. Reumatologie en Klinische Immunologie, Utrecht.

Psoriasis is a common immune-mediated inflammatory condition that primarily affects skin and nails. 6-41% of psoriasis patients develop psoriatic arthritis (PsA). The ways in which PsA can manifest itself include peripheral arthritis, axial spondyloarthritis, dactylitis and enthesitis. Read More

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July 2019
3 Reads

Evaluating nail thickness and stiffness with shear-wave elastography in nail psoriasis: A preliminary study.

Skin Res Technol 2020 Jan 23;26(1):45-49. Epub 2019 Jul 23.

Department of Radiology, Van research and Education Hospital, Van, Turkey.

Introduction: Psoriasis is a chronic, relapsing skin disease affecting millions of people worldwide. Nail changes have been reported to occur in up to 40% of patients with mild psoriasis and 50%-70% with severe disease. Shear-wave elastography (SWE) is a new non-invasive ultrasonic technique that evaluates thickness and stiffness of tissues. Read More

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http://dx.doi.org/10.1111/srt.12762DOI Listing
January 2020

Nails: The External Protective Window to the Internal Milieu.

Adv Skin Wound Care 2019 Aug;32(8):341

R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med Derm), FAAD, MAPWCA, JM, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Professor, Medicine and Public Health, University of Toronto, Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana Faculty of Public Health, University of Toronto; Project Lead, Project ECHO Ontario Wound and Skin; and Investigator, Institute for Better Health, Trillium Health. Elizabeth A. Ayello, PhD, RN, CWON, ETN, MAPWCA, FAAN, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Faculty, Excelsior College School of Nursing, Albany, New York; President, World Council of Enterostomal Therapists, President, Ayello Harris & Associates, Inc, Copake, New York; and President (1999), National Pressure Ulcer Advisory Panel.

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http://dx.doi.org/10.1097/01.ASW.0000574988.19035.30DOI Listing
August 2019
4 Reads

Nail pitting: a key clinical sign of psoriatic arthritis.

Rheumatology (Oxford) 2019 12;58(12):2250

Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/kez183DOI Listing
December 2019
1 Read
4.475 Impact Factor

A Study on the Association of Psoriasis with Metabolic Disorders.

J Assoc Physicians India 2019 Apr;67(4):52-54

HOD and Professor, Department of Dermatology, Venereology and Leprology, Dr. D.Y. Patil Hospital and Research centre, Navi Mumbai, Maharashtra.

Background: Psoriasis is a chronic inflammatory and hyper-proliferative skin disorder which is chronically relapsing with high morbidity and impaired quality of life, characterized by erythematous scaly patches affecting skin, joints and nails. It is a disorder of immune system involving genetic, immunologic and environtmental factors. Metabolic syndrome (also known as metabolic syndrome X) is a grouping of interrelated medical traits that, when present, indicate an increased risk of developing noninsulin-dependent diabetes mellitus and/or cardiovascular disease. Read More

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April 2019
4 Reads

Inverse responses of the skin and nail lesions of psoriatic arthritis to an anti-interleukin-17A antibody and an anti-tumor necrosis factor-α antibody.

J Dermatol 2019 Nov 28;46(11):e440-e441. Epub 2019 Jun 28.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/1346-8138.15006DOI Listing
November 2019
5 Reads

Efficacy of the combination of superficial shaving with photodynamic therapy for recalcitrant periungual warts.

Photodiagnosis Photodyn Ther 2019 Sep 25;27:340-344. Epub 2019 Jun 25.

Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 41008, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, 410008, China; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:

Background: Periungual warts are a viral infectious disease that occurs in a particular location. It is difficult to eliminate completely, and recurrence is common. Photodynamic therapy (PDT) as an option that has been widely recommended to treat viral warts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000193021
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http://dx.doi.org/10.1016/j.pdpdt.2019.06.021DOI Listing
September 2019
12 Reads

Spotlight on itolizumab in the treatment of psoriasis - current perspectives from India.

Psoriasis (Auckl) 2019 3;9:19-27. Epub 2019 May 3.

Department of Endocrinology, MS Diabetes Centre, Indiranagar, Bangalore 560038, India.

Psoriasis is a chronic, debilitating, immune-mediated, systemic inflammatory disease affecting mainly skin, nails, and joints. Several therapeutic modalities are available depending on the severity of the disease. Long-term use of these drugs results in unwanted effects and toxicities. Read More

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http://dx.doi.org/10.2147/PTT.S154073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501705PMC
May 2019
9 Reads

Nail Anatomy, Nail Psoriasis, and Nail Extensor Enthesitis Theory: What Is the Link?

Am J Dermatopathol 2019 Jun;41(6):399-409

Staff Physician, The Laboratoire Central d'Anatomie Pathologique, Hôpital L. Pasteur, University of Nice, France.

The concept of the nail unit as a musculoskeletal appendage has become popular in the dermatological and rheumatological literature. However, an exact knowledge of the characteristics of mesenchyme surrounding the nail such as the composition of the collagen and elastic fibers and their arrangement is fundamental before one can propose a constitutive model. To the best of my knowledge, there is no study in the literature concerning the elastic network of the ligamentous connective tissue of the base of the distal phalanx. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001244DOI Listing
June 2019
4 Reads

Smoking does not Alter the Therapy Response to Systemic Anti-psoriatic Therapies: A Two-country, Multi-centre, Prospective, Non-interventional Study.

Acta Derm Venereol 2019 Sep;99(10):871-877

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.

Psoriasis can involve the skin, joints, nails and cardiovascular system and result in a significant impairment in quality of life. Studies have shown a lower response rate to systemic anti-psoriatic therapies in smokers, and smoking is a trigger factor for psoriasis. The aim of this study was therefore to analyse the response to systemic therapies for psoriasis, with a focus on smoking. Read More

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http://www.medicaljournals.se/acta/content/abstract/10.2340/
Publisher Site
http://dx.doi.org/10.2340/00015555-3221DOI Listing
September 2019
8 Reads

A 15-year retrospective study on the prevalence of onychomycosis in psoriatic vs non-psoriatic patients: A new European shift from dermatophytes towards yeast.

Mycoses 2019 Aug 23;62(8):659-664. Epub 2019 May 23.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Because of their similar clinical presentation, discrimination between nail psoriasis and onychomycosis often is difficult. We aim to investigate the actual frequency of onychomycosis in psoriatic patients and to compare it between psoriatic and non-psoriatic patients. This retrospective study included a total of 9281 patients, referring to our Mycology Laboratory from September 2003 to May 2018. Read More

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http://dx.doi.org/10.1111/myc.12925DOI Listing
August 2019
4 Reads

Nails as immune-privileged sites: A case of disabling Acrodermatitis continua of Hallopeau successfully treated with Apremilast.

Dermatol Ther 2019 07 7;32(4):e12946. Epub 2019 May 7.

Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Acrodermatitis continua of Hallopeau (ACH) is a chronic, inflammatory, and relapsing disorder characterized by the progressive destruction of fingernails and toenails. This condition is rare, difficult to treat, and often misdiagnosed. Several antipsoriatic treatments have been used, without any therapeutic guideline and no real improvement. Read More

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http://dx.doi.org/10.1111/dth.12946DOI Listing
July 2019
9 Reads

Patient preference for biologic treatments of psoriasis in Japan.

J Dermatol 2019 Jun 15;46(6):466-477. Epub 2019 Apr 15.

AbbVie GK, Tokyo, Japan.

Psoriasis is a chronic autoimmune disease affecting skin which may also manifest in nails and joints. Several biologic treatments have been approved in Japan for psoriasis. Each biologic has a different profile for efficacy and safety, including different dosing regimens and co-payment considerations which may complicate treatment decisions made by patients and physicians during short consultations. Read More

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http://dx.doi.org/10.1111/1346-8138.14870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594072PMC
June 2019
22 Reads

Successful treatment of psoriatic crumbly nails with ustekinumab.

Dermatol Ther 2019 05 21;32(3):e12914. Epub 2019 Apr 21.

Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.

Nail involvement can place a significant burden on patients as a result of functional damage and psychosocial problems, leading to major repercussions on the quality of life. There is strong evidence that nail psoriasis can often be difficult to treat. We report a 69-year-old man with severe onychodystrophy, onycholysis, and pain in the hands; he had been previously treated with topical and systemic traditional therapies without satisfactory response. Read More

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http://dx.doi.org/10.1111/dth.12914DOI Listing
May 2019
10 Reads

Nail Changes in Sézary Syndrome: A Single-Center Study and Review of the Literature.

J Cutan Med Surg 2019 Jul/Aug;23(4):380-387. Epub 2019 Mar 27.

1 Cutaneous Lymphoma Program, Department of Dermatology, University of Pittsburgh Medical Center, PA, USA.

Background: The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications.

Objectives: The objectives of this study were to identify and describe the most frequent nail alterations in patients with SzS. Read More

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http://journals.sagepub.com/doi/10.1177/1203475419839937
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http://dx.doi.org/10.1177/1203475419839937DOI Listing
January 2020
10 Reads

What's New in Nail Disorders.

Dermatol Clin 2019 Apr 14;37(2):143-147. Epub 2019 Feb 14.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 Northwest 10th Avenue #1140, Miami, FL 33136, USA.

Various advancements in the diagnosis and management of nail diseases have transpired in recent years. To provide the best care for patients with nail complaints, it is essential that physicians be updated on new diagnostic and treatment modalities. The purpose of this article is to discuss new and oncoming diagnostic and management options for nail disorders, including nail psoriasis, retronychia, brittle nails, onychotillomania, trauma, trachyonychia, and pyogenic granulomas. Read More

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http://dx.doi.org/10.1016/j.det.2018.12.004DOI Listing
April 2019
8 Reads

Distal interphalangeal joint extensor tendon enthesopathy in patients with nail psoriasis.

Sci Rep 2019 03 6;9(1):3628. Epub 2019 Mar 6.

Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900, Olsztyn, Poland.

The aim of the study was an ultrasound assessment of distal interphalangeal (DIP) joint enthesopathy in patients with nail psoriasis. Altogether, 72 patients with nail psoriasis (41 with psoriasis and 31 with psoriatic arthritis) and 30 people in the control group participated in the study. In total, 1014 nails were examined. Read More

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http://dx.doi.org/10.1038/s41598-019-39985-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403314PMC
March 2019
15 Reads

Pediatric lichen nitidus: A single-center experience.

Pediatr Dermatol 2019 Mar 11;36(2):189-192. Epub 2019 Feb 11.

Department of Pathology, Dr. Behcet Uz Children's Research and Training Hospital, Izmir, Turkey.

Objective: Lichen nitidus (LN) is an uncommon inflammatory skin eruption. The present study aims to describe a case series of children with LN seen at a tertiary-care health center.

Methods: Retrospective study of 17 children with biopsy-proven LN between January 2007 and March 2017. Read More

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http://doi.wiley.com/10.1111/pde.13749
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http://dx.doi.org/10.1111/pde.13749DOI Listing
March 2019
37 Reads

Recommendations for the definition, evaluation, and treatment of nail psoriasis in adult patients with no or mild skin psoriasis: A dermatologist and nail expert group consensus.

J Am Acad Dermatol 2019 Jul 5;81(1):228-240. Epub 2019 Feb 5.

Greater Miami Skin and Laser Center, Department of Dermatology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.

Nail involvement in psoriasis is common, and the severity of it does not always parallel the intensity of cutaneous disease. We created a consensus group, of which the aim was to provide practical recommendations for the treatment of nail psoriasis in patients without skin psoriasis or with mild skin lesions with no indication for a systemic treatment. This collaborative process was conducted by an international panel of dermatologists with special expertise in nail disorders, using formal consensus methods. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.072DOI Listing
July 2019
28 Reads

The "green nail" phenomenon in ICG-enhanced fluorescence optical imaging - a potential tool for the differential diagnosis of psoriatic arthritis.

J Dtsch Dermatol Ges 2019 Feb 31;17(2):138-147. Epub 2019 Jan 31.

Department of Dermatology and Allergology, Evangelical Hospital, Düsseldorf, and Faculty of Health, Department of Medicine, University of Witten/Herdecke, Germany.

Background And Objectives: Early diagnosis of psoriatic arthritis poses a particular challenge. A novel fluorescence optical imaging technique, the Xiralite® system is very useful in this regard as it allows for visualization of microvasculature and perfusion. The present study is the first to systematically examine fluorescence optical signals in a large psoriatic arthritis cohort. Read More

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http://dx.doi.org/10.1111/ddg.13747DOI Listing
February 2019
7 Reads

Localization of treatment-resistant areas in patients with psoriasis on biologics.

Br J Dermatol 2019 08 7;181(2):332-337. Epub 2019 May 7.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Traditionally, psoriasis in certain body sites such as the scalp, nails, palms, soles and intertriginous areas has been acknowledged as difficult to treat.

Objectives: To investigate the body location of treatment-resistant psoriasis in patients treated with biologic agents in real-world clinical practice, and to study the association between localization and quality of life.

Methods: This was an observational, noninterventional, study. Read More

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http://dx.doi.org/10.1111/bjd.17689DOI Listing
August 2019
4 Reads

Psoriasis in special localizations.

Reumatologia 2018 23;56(6):392-398. Epub 2018 Dec 23.

Department of Dermatology, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland.

Psoriasis is a chronic inflammatory dermatosis affecting 1-3% of the general population. Patients with psoriasis represent a heterogeneous population with individual disease expression - different degrees and severity of skin involvement. Psoriatic lesions in particular localizations such as the face, scalp, intertriginous or palmoplantar areas significantly reduce quality of life. Read More

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https://www.termedia.pl/doi/10.5114/reum.2018.80718
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http://dx.doi.org/10.5114/reum.2018.80718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330687PMC
December 2018
26 Reads

The ultrasonographic study of the nail reveals differences in patients affected by inflammatory and degenerative conditions.

Clin Rheumatol 2019 Mar 15;38(3):913-920. Epub 2019 Jan 15.

Rheumatology Unit, Department of Medicine, University of Verona, Piazzale A. L. Scuro 1, 37138, Verona, Italy.

Introduction And Objectives: The nail unit is a subject of interest in several diseases, often involving different medical fields. Even if few data are available for psoriasis and psoriatic arthritis, no data regarding ultrasonography and imaging are present for other degenerative and inflammatory conditions. The aim of this study was to explore through imaging the changes of nail and enthesis in inflammatory and degenerative conditions in order to find qualitative and quantitative changes related to distal interphalangeal joints. Read More

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http://link.springer.com/10.1007/s10067-019-04437-0
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http://dx.doi.org/10.1007/s10067-019-04437-0DOI Listing
March 2019
34 Reads