46,912 results match your criteria Psoriasis Forum [Journal]


Mycosis fungoides, Psoriasis and Anti-PD-1 - A New Aspect of Known Associations.

J Dtsch Dermatol Ges 2018 Dec 14. Epub 2018 Dec 14.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.

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December 2018

Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Pustulotic arthro-osteitis, occasionally complicated with palmoplantar pustulosis, affects patients' activities of daily living. Granulocyte and monocyte adsorption apheresis selectively removes activated granulocytes and monocytes by means of extracorporeal circulation. Although the efficacy of granulocyte and monocyte adsorption apheresis in the treatment of generalized pustular psoriasis has been proved, very few reports have assessed its efficacy in the treatment of palmoplantar pustulosis and pustulotic arthro-osteitis. Read More

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December 2018
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Anti-psoriatic effect of myeloid-derived suppressor cells on imiquimod-induced skin inflammation in mice.

Scand J Immunol 2018 Dec 13:e12742. Epub 2018 Dec 13.

Pharmicell Co, Ltd, 484, Dunchon-daero, Jungwon-gu, Seongnam, Gyeonggi-do, Korea.

Myeloid-derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti-psoriatic effect of MDSCs on IMQ-induced skin inflammation in mice and explored the mechanisms involved. Read More

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December 2018
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Long-term safety and drug survival of acitretin in psoriasis: a retrospective observational study.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: This retrospective observational study aimed to investigate the long-term safety, drug survival, and factors associated with the survival of acitretin in a real-world setting.

Methods: Data of adult patients with psoriasis who attended Siriraj Hospital between 2012 and 2017 and were treated with acitretin were reviewed. Demographic data and clinical courses were recorded. Read More

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December 2018

Efficacy of several biological therapies for treating moderate to severe psoriasis: A network meta-analysis.

Exp Ther Med 2018 Dec 15;16(6):5085-5095. Epub 2018 Oct 15.

Department of Dermatology, The Second Hospital of Liaocheng, Linqing, Shandong 252601, P.R. China.

The aim of the present meta-analysis was to systematically assess the efficacy of the various treatments available for moderate to severe psoriasis. PubMed and Embase databases were systematically searched to select relevant studies up to February 2015. Odds ratios (ORs) and their 95% confidence intervals (CIs) were used as effect estimates. Read More

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December 2018

Three Constituents of Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

As a folk medicine, L. is used effectively to treat inflammatory conditions and skin diseases. However, its mechanism of action is not well understood, limiting its medical use. Read More

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December 2018

A20 and ABIN1 suppression of a keratinocyte inflammatory program with a shared single cell expression signature in diverse human rashes.

J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, UCSF and Veterans Affairs Medical Center, San Francisco, California, USA. Electronic address:

Genetic variation in the NFκB inhibitors, ABIN1 and A20, increase risk for psoriasis. While critical for hematopoietic immune cell function, these genes are believed to additionally inhibit psoriasis by dampening inflammatory signaling in keratinocytes. We dissected ABIN1 and A20's regulatory role in human keratinocyte inflammation using an RNA-seq based comparative genomic approach. Read More

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December 2018

Endothelial Dysfunction in Children with Juvenile Psoriatic Arthritis.

Acta Medica (Hradec Kralove) 2018 ;61(3):79-85

Department of Dermatology, A. Reiman's Hospital, Prešov, Slovakia.

Background: To evaluate the presence of endothelial dysfunction in Slovak children with juvenile psoriatic arthritis in the absence of classic cardiovascular risk factors in order to assess its relationship to the disease activity and disability.

Methods: 25 juvenile psoriatic arthritis patients (JPSA) and 25 healthy controls aged 6-19 years were enrolled into this study. In all subjects vascular measurements over a period of three years (January 2013 - January 2016) were performed, in accordance with the guidelines for ultrasonographic evaluation of FMD% (flow-mediated endothelial dependent vasodilatation) of the brachial artery. Read More

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January 2018

Beliefs About Medicines in Patients with Psoriasis Treated with Methotrexate or Biologics: A Cross-sectional Survey Study.

Acta Derm Venereol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Radboud university medical center, 6500 HB Nijmegen, The Netherlands.

Methotrexate (MTX) and biologics are frequently used treatments for psoriasis. Exploring patients' beliefs about their treatment may help to elucidate patients' attitudes towards these therapies. A cross-sectional survey was conducted using the Beliefs about Medicines Questionnaire-Specific (BMQ-Specific) in patients treated with methotrexate or biologics. Read More

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December 2018

Spontaneous Cure of Acute Hepatitis C.

Curr Health Sci J 2015 Oct-Dec;41(4):375-378. Epub 2015 Dec 22.

Department of Gastroenterology and Hepatology, Universitary Hospital Santa Maria, Lisbon.

The statistics proved that approximately 25% of the patients with acute HCV present with jaundice, and only 10-20% develop gastrointestinal symptoms. We present the case of a 58 year-old woman, with prior antecedents of arterial hypertension and diabetes mellitus since 25 years old, hypercholesterolemia and hypertriglyceridemia, psoriasis, epilepsy and depressive syndrome. She clinically presents asthenia, anorexia, itching, jaundice and choluria. Read More

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December 2015

The economic burden of psoriasis with high comorbidity among privately insured patients in the United States.

J Med Econ 2018 Dec 7:1-16. Epub 2018 Dec 7.

a Analysis Group, Inc ., Montréal , Québec , Canada.

Objective: To evaluate the impact of comorbidities on healthcare resource use (HRU), and direct and indirect work-loss-related costs in psoriasis patients.

Methods: Adults with psoriasis (≥2 diagnoses, the first designated as the index date) and non-psoriasis controls (no psoriasis diagnoses, randomly generated index date) were identified in a US healthcare claims database of privately-insured patients (data between 01/2010 and 03/2017 were used). Psoriasis patients were stratified based on the number of psoriasis-related comorbidities (0, 1-2, or ≥3) developed during the 12 months post-index. Read More

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December 2018

Lack of association of the IL-1RN and IL-10 polymorphisms with risk of psoriasis: A meta-analysis.

Mol Genet Genomic Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The present study carried out a meta-analysis to investigate whether the interleukin-1 receptor antagonist (IL-1RN) VNTR polymorphism and three IL-10 single-nucleotide polymorphisms (SNPs) rs1800896, rs3021097, and rs1800872 are associated with psoriasis risk.

Methods: Wanfang, China National Knowledge Infrastructure, Medline, and PubMed databases were searched for potential studies published until 2 November 2017. Forest plots were generated. Read More

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December 2018

An Unusual Presentation of Lupus Vulgaris and the Practical Usefulness of Dermatoscopy.

Case Rep Dermatol Med 2018 14;2018:1036162. Epub 2018 Nov 14.

Specialist in Dermatology-Venereology, Chief of State Clinic of Dermatology, Hospital for Skin and Venereal Diseases, Delfon 124, 54643 Thessaloniki, Greece.

We report a case report of lupus vulgaris (LV) presented on the extremities of an 80-year-old man. He was misdiagnosed as having psoriasis and referred to our department for a second-opinion evaluation. The discrepancy between the clinical manifestation which was misleading and the dermatoscopic findings raised the suspicion of an underlying granulomatous disease and we proceeded to skin biopsy. Read More

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November 2018
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Contribution of Nail Fold Videocapillaroscopy in Patients with Early Inflammatory Arthritis.

Curr Health Sci J 2015 Jul-Sep;41(3):233-238. Epub 2015 Mar 15.

Rheumatology Department, University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Romania.

Background: Early inflammatory arthritis (EIA) a condition defined by joint swelling, with or without morning stiffness, and/or swelling of metacarpophalangeal and/or metatarsophalangeal joints. Nail fold video-capillaroscopy (NVC) is important for the evaluation of microcirculation in vivo. There are limited data about the role of NVC in EIA. Read More

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Pediatric Dermatology - critical approach to the new treatments.

Dermatol Ther 2018 Dec 7:e12801. Epub 2018 Dec 7.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.

The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. Read More

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December 2018
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Successful sclerotherapy and psoriasis: A discussion of koebnerization, report of two cases, and review of the literature.

J Cosmet Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

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December 2018

Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

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December 2018
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Risk of skin cancer in psoriasis patients receiving long-term narrowband ultraviolet phototherapy: results from a Taiwanese population-based cohort study.

Photodermatol Photoimmunol Photomed 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Taichung Veterans General Hospital, Taichung.

Background: Narrow-band ultraviolet B (NB-UVB) phototherapy is a widely used treatment for various dermatoses. The risk of skin cancer following long term NB-UVB phototherapy has rarely been explored in skin phototypes III-V.

Methods: We conducted a nationwide matched cohort study and identified a total of 22,891 psoriasis patients starting NB-UVB phototherapy from the Taiwan National Health Insurance Database during the period 2000-2013. Read More

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December 2018
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Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosis.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Dimethyl fumarate (DMF) is an important oral treatment option for various autoimmune diseases, such as multiple sclerosis (MS) and psoriasis. DMF and its dynamic metabolite, monomethyl fumarate (MMF) are the major compounds that exert therapeutic effects on several pathologic conditions in part, through downregulation of immune responses. The exact mechanism of DMF is yet to be fully understood even though its beneficial effects on the immune system are extensively studied. Read More

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December 2018
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3.839 Impact Factor

Outcome of pregnancy in women with psoriatic arthritis compared to healthy controls.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Centre for Prognosis Studies in the Rheumatic Diseases, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Objectives: The mean age at onset of psoriatic arthritis (PsA) ranges between the 4th-6th decades of life. However, little is known about fertility and pregnancy outcome in PsA patients. The aim of this study was to examine whether fertility and pregnancy outcome of PsA patients are different from healthy controls and to evaluate PsA and psoriasis disease activity perception during pregnancy and the year postpartum. Read More

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December 2018
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To what extend is nail ultrasound discriminative between psoriasis, psoriatic arthritis and healthy subjects?

Rheumatol Int 2018 Dec 10. Epub 2018 Dec 10.

Department of Social Psychology and Methodology, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, Spain.

To assess the discriminative utility of nail features detected by B-mode (BM) and color Doppler (CD) ultrasound (US) between patients with psoriasis (PsO) and psoriatic arthritis (PsA) and healthy controls. Sixty patients with PsA, 21 patients with PsO, and 20 healthy controls were prospectively included. All patients underwent a dermatologic assessment and PsA patients also a rheumatologic assessment. Read More

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December 2018

Delayed Diagnosis of Psoriatic Arthritis Mutilans due to Arthritis Prior to Skin Lesion.

Case Rep Rheumatol 2018 4;2018:4216938. Epub 2018 Nov 4.

Department of Orthopedic Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Psoriatic arthritis (PsA) is a type of inflammatory arthritis characterized by cutaneous psoriasis, peripheral joint damage, axial joint damage, and enthesitis and is usually diagnosed after the appearance of psoriatic skin disease. PsA mutilans is relatively rare in Japan. In the present case, the patient was diagnosed with PsA with foot mutilans deformity only. Read More

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November 2018

Severity evaluation and prognostic factors in erythrodermic psoriasis.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

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December 2018

Evaluation of the possible use of genus Mentha derived essential oils in the prevention of SENLAT syndrome caused by Rickettsia slovaca.

J Ethnopharmacol 2018 Dec 5. Epub 2018 Dec 5.

Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia.

Ethnopharmacological Relevance: Essential oils and essential oil bearing medicinal and culinary plants have a long tradition of being used to combat infection, treat various conditions, and promote and restore health. Mint oils are traditionally applied to repel insects and treat various conditions including wounds, skin infections, inflammation, eczema, urticaria, psoriasis, scabies and insect bites. They are among essential oils promoted as a natural way to prevent tick-borne diseases and recommended as ingredients in various homemade repellent mixtures and tick-bite treatments. Read More

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December 2018

A trans-ethnic Mendelian randomization study identifies causality of obesity on risk of psoriasis.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan. Electronic address:

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December 2018

The IL-1 pathway is hyperactive in Hidradenitis suppurativa and contributes to skin infiltration and destruction.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Interdisciplinary group Molecular Immunopathology, Dermatology / Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Psoriasis Research and Treatment Center, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory disease characterized by painful purulent skin lesions and progressive destruction of skin architecture. Despite the high burden for the patients, pathogenetic pathways underlying HS alterations remain obscure. Investigating the lesional HS cytokine pattern, IL-1β turned out as a highly prominent cytokine, being overexpressed even compared to psoriatic lesions. Read More

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December 2018

Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Dermatology, University of Michigan, Ann Arbor, MI, United States; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, United States. Electronic address:

Psoriasis lesions are rich in IL-17-producing T-cells as well as neutrophils, which release webs of DNA-protein complexes known as neutrophil extracellular traps (NETs). Because we and others have observed increased NETosis in psoriatic lesions, we hypothesized that NETs contribute to increased Th17 cells in psoriasis. After stimulating peripheral blood mononuclear cells (PBMCs) with anti-CD3/CD28 beads for 7 days, we found significantly higher percentages of CD3+CD4+IL-17+ (Th17) cells in the presence vs. Read More

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December 2018

Micro-scaled topographies direct differentiation of human epidermal stem cells.

Acta Biomater 2018 Dec 5. Epub 2018 Dec 5.

Centre for Stem Cells and Regenerative Medicine, King's College London, 28th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom. Electronic address:

Human epidermal stem cells initiate terminal differentiation when spreading is restricted on ECM-coated micropatterned islands, soft hydrogels or hydrogel-nanoparticle composites with high nanoparticle spacing. The effect of substrate topography, however, is incompletely understood. To explore this, primary human keratinocytes enriched for stem cells were seeded on a topographical library with over 2000 different topographies in the micrometre range. Read More

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December 2018

Smoking, but not alcohol, is associated with risk of psoriasis in a Taiwanese population-based cohort study.

J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Public Health and Department of Public Health, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background: Alcohol consumption and smoking have long been suspected of increasing the risk of developing psoriasis. Most evidence to date has derived from cross-sectional or case-control studies.

Objective: We sought to investigate the effects of alcohol and smoking on incident psoriasis. Read More

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December 2018
4.449 Impact Factor

Increased risk of incident thyroid diseases in people with psoriatic disease: A cohort study.

J Am Acad Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: The association between psoriasis and thyroid diseases was unclear.

Objective: To examine the risk of thyroid diseases in psoriasis patients.

Methods: We used Taiwan's National Health Insurance Research Database to conduct a nationwide cohort study. Read More

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December 2018
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The influence of interferon on healthy and diseased skin.

Cytokine 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More

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December 2018
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Consensus Statement on the Psychological Needs of Patients With Chronic Inflammatory Skin Diseases.

Actas Dermosifiliogr 2018 Dec 5. Epub 2018 Dec 5.

Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España.

Objective: To establish recommendations to determine, identify, and manage the psychological and emotional needs of patients with chronic inflammatory skin diseases in clinical practice.

Methods: A guided discussion was held at meeting of a nominal group of expert dermatologists and psychologists on the psychological and emotional needs of patients with chronic inflammatory skin diseases, how to manage these cases, and which referral criteria to employ. Based on the results of the discussion, and with the aid of a patient focus group and a review of the literature, a master document was drawn up with recommendations for discussion. Read More

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December 2018

TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.

J Dermatol Sci 2018 Nov 26. Epub 2018 Nov 26.

Department of Dermatology, University of California, Davis, CA, USA. Electronic address:

Background: Transient Receptor Potential Vanilloid 1 (TRPV1) is known to mediate itch and neurogenic inflammation, but the role of TRPV1 in psoriasiform dermal inflammation is poorly understood.

Objective: To investigate the function of TRPV1 in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.

Methods: Following daily treatment of topical IMQ cream for consecutive 5 days in C57BL/6 wide-type (WT) and TRPV1 gene knockout (KO) mice, we assessed the psoriasis severity index (PSI) scores, transepidermal water loss (TEWL), dermal inflammatory infiltrates, as well as gene expression levels for psoriasis related genes in mouse skin lesions. Read More

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November 2018

JAK-STAT inhibitors for the treatment of immunomediated diseases.

Med Clin (Barc) 2018 Dec 4. Epub 2018 Dec 4.

Servicio de Reumatología, Hospital de La Princesa, Instituto de Investigación (IIS)-Princesa, Madrid, España. Electronic address:

The Janus kinase (JAK) pathway is implicated in the pathogenesis of many inflammatory and autoimmune diseases including rheumatoid arthritis (RA), psoriasis, and inflammatory bowel disease. There are a lot of proinflammatory cytokines involved in such diseases using this pathway to transduce intracellular signals. In the last years, JAK inhibitors (jakinibs) have appeared with a great success, showing that these kinds of drugs have a great applicability in clinical practice. Read More

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December 2018

Secukinumab in the therapy of psoriasis and psoriatic arthritis: a safe choice in clinical practice.

J Dermatolog Treat 2018 Dec 8:1-4. Epub 2018 Dec 8.

a Dermatology Unit, Department of Clinical and Translational Medicine , University of Pisa , Pisa , Italy.

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December 2018
3 Reads

Genus Psoralea A review of the traditional and modern uses, phytochemistry and pharmacology.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

CSIR-National Botanical Research Institute, Plant Transgenic Laboratory, P.O. Box 436, Rana Pratap Marg,Lucknow-226 001, U.P., India. Electronic address:

Ethnopharmacological Relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. Read More

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December 2018
9 Reads

Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Read More

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December 2018
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Nail Psoriasis: An Updated Review and Expert Opinion on Available Treatments, Including Biologics.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 1, IT-40138 Bologna, Italy.

Nail psoriasis affects 50-79% of patients with skin psoriasis and up to 80% of patients with psoriatic arthritis, and can also represent a negative prognostic factor in individuals with plaque psoriasis. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies alone, and relapse is common. Among different systemic agents, secukinumab, a fully human monoclonal antibody targeting interleukin (IL)-17A, is the only antibody supported by a trial specifically conducted in patients with nail psoriasis (the TRANSFIGURE trial) and has the longest follow-up available to date. Read More

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December 2018
5 Reads

Systemic therapies of pityriasis rubra pilaris: a systematic review.

J Dtsch Dermatol Ges 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Venereology, and Allergology, University Medical Centre, Göttingen, Germany.

Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder. Treatment is challenging; the armamentarium consists of topical corticosteroids, phototherapy, classic systemic treatments such as retinoids or immunosuppressive drugs, and most recently biologicals. However, the relative effectiveness of therapies is unclear. Read More

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December 2018
1 Read

Itch relief in patients with psoriasis: effectiveness of calcipotriol plus betamethasone dipropionate foam.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Comprehensive Center for Inflammation Medicine, University of Luebeck, Luebeck, Germany.

Background: Itch is common in psoriasis, adversely affecting health-related quality of life (HRQoL) and sleep.

Objective: We evaluated the efficacy of topical fixed-dose combination calcipotriol 50 μg/g plus betamethasone dipropionate 0.5 mg/g cutaneous foam (Cal/BD foam) on itch, itch-related sleep loss and HRQoL versus foam vehicle. Read More

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December 2018
2 Reads

Metformin inhibits pro-inflammatory responses via targeting nuclear factor-κB in HaCaT cells.

Cell Biochem Funct 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Chinese PLA General Hospital & Medical School, Beijing, China.

Psoriasis is a prevalent, chronic inflammatory skin disease that arises from rapid and excessive growth of keratinocytes induced by abnormal inflammatory responses. Metformin is the first-line drug in type 2 diabetes and has been proven to possess significant anti-inflammatory effects in various diseases. In the present study, we examined the role of metformin in nuclear factor kappa B (NF-κB)-mediated inflammatory responses in HaCaT cells, a cell line for the keratinocyte. Read More

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December 2018
4 Reads

Spotlight on risankizumab and its potential in the treatment of plaque psoriasis: evidence to date.

Psoriasis (Auckl) 2018 13;8:83-92. Epub 2018 Nov 13.

Department of Dermatology, Centro Hospitalar Universitário do Porto, Porto, Portugal,

Psoriasis is a common chronic immune-mediated skin disease, with systemic involvement and significant impact in patients' quality of life. Several highly specific treatments have been developed over the years, such as tumor necrosis factor-α inhibitors, a nonselective IL-23 inhibitor (ustekinumab), and most recently IL-17 inhibitors. Risankizumab is a monoclonal antibody which targets IL-23p19 without binding IL-12. Read More

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November 2018
7 Reads

Curative Anti-Inflammatory Properties of Chinese Optimized Yinxieling Formula in Models of Parkinson's Disease.

Evid Based Complement Alternat Med 2018 4;2018:6142065. Epub 2018 Nov 4.

Second Clinical Medical College, Guangzhou University of Chinese Medicine, 232 Waihuan Road E, Guangzhou, Guangdong 510006, China.

Parkinson's disease (PD) is marked by the progressive degeneration of dopaminergic neurons (DAN) accompanied by glial activation. Thus, inhibiting glial activation that occurs during this disease could be an effective method for treating PD. Optimized Yinxieling Formula (OYF), a Chinese medicinal formula, which is used to efficiently treat autoimmune disease psoriasis, has been proved to display potential immunomodulatory effects in inflammation-associated diseases. Read More

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November 2018
1 Read

Cost effectiveness of ixekizumab versus secukinumab in the treatment of moderate-to-severe plaque psoriasis in Spain.

Clinicoecon Outcomes Res 2018 12;10:747-759. Epub 2018 Nov 12.

Global Patient Outcomes and Real World Evidence International, Eli Lilly, Surrey, UK.

Background: Currently, several biologic agents are available for the treatment of moderate-to-severe plaque psoriasis, including newer agents with similar mechanisms of action and efficacy; therefore, there is a need to evaluate their efficiency in terms of cost effectiveness.

Objective: This study evaluates the cost effectiveness of recently approved interleukin (IL)-17A antagonists, ixekizumab and secukinumab, for the treatment of moderate-to-severe plaque psoriasis from the perspective of the Spanish National Health System (NHS).

Materials And Methods: A Markov model with a lifetime horizon was developed to compare the cost effectiveness of ixekizumab vs. Read More

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November 2018
2 Reads

Risankizumab: an anti-IL-23 antibody for the treatment of psoriasis.

Drug Des Devel Ther 2018 12;12:3879-3883. Epub 2018 Nov 12.

Department of Dermatology, Baylor University Medical Center, Dallas, TX, USA,

Risankizumab, a fully human IgG monoclonal antibody inhibitor of IL-23, is a therapeutic agent currently in late stage development for use in the treatment of moderate-to-severe plaque psoriasis. It is a biologic agent similar to guselkumab and tildrakizumab which targets IL-23 specifically, and has been primarily developed for use in moderate-to-severe psoriasis. USA-based pharmaceutical company Abbvie submitted it for a Biologics License Application to the US Food and Drug Administration (FDA) in April 2018. Read More

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November 2018
2 Reads

Analysis of drug utilization and health care resource consumption in patients with psoriasis and psoriatic arthritis before and after treatment with biological therapies.

Biologics 2018 12;12:151-158. Epub 2018 Nov 12.

Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.

Objectives: To describe the therapeutic pathways of patients with psoriasis (PSO) and psoriatic arthritis (PsA) before and after treatment with biological therapies in a real-world setting and to determine the relative consumption of health care resources.

Design: Retrospective observational study.

Setting: Real-life clinical setting in 5 Italian local health units. Read More

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November 2018
1 Read

Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

VEGF-C is an important mediator of lymphangiogenesis and has been shown to alleviate chronic inflammation in a variety of disease models. In this study, we investigated whether targeted delivery of VEGF-C to sites of inflammation and site-specific activation of lymphatic vessels would represent a clinically feasible strategy for treating chronic skin inflammation. To this end, we generated a fusion protein consisting of human VEGF-C fused to the F8 antibody (F8-VEGF-C), which is specific for the alternatively spliced, angiogenesis-marking extradomain A (EDA) of fibronectin. Read More

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December 2018
1 Read

Evaluation of IL-17 Producing Memory Regulatory and Effector T Cells Expressing CD26 Molecule in Patients with Psoriasis.

Iran J Allergy Asthma Immunol 2018 Oct 14;17(5):453-463. Epub 2018 Oct 14.

Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Immunology, Asthma and Allergy Research Institute (IAARI), Tehran University of Medical Sciences, Tehran, Iran.

Memory regulatory T cells (Tregs) has been demonstrated to produce IL-17 in Psoriasis. Forkhead box P3 (Foxp3) has been demonstrated not to be reliable marker to evaluate Treg cells. Effector CD4+T cells also express Foxp3 after activation. Read More

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October 2018
1 Read